Curriculum vitae

PERSONAL INFORMATION

Rolf Karlsten

WORK EXPERIENCE January 2013–Present

Head of Rehabilitation medicine and Pain Centre Uppsala university hospital, (Sweden) Senior Consultant Head of rehabilitaion medicine and pain centre19

October 2002–December 2012

Medical Science Director AstraZeneca, (Sweden) Clinical development, neuroscience, analgesia

August 1986–September 2002

Consultant, senior consultant Uppsala university hospital, (Sweden) Pain center Anaesthesiology Emergency medicine

EDUCATION AND TRAINING 1977–1982

Medical doctor Uppsala university, (Sweden)

1984–1988

Specialist in anaesthesiology Uppsala university hospital, (Sweden)

1988–1993

PhD, anaestesiology Uppsala university, (Sweden)

2004–2006

Diploma in Pharmaceutical medicine Karoliniska Institute, (Sweden)

ADDITIONAL INFORMATION Expertise

Pain management Anaestesiology Emergency medicine Pharmaceutical medicine

Publications

1. Karlsten R, Gordh T, Hartvig P, Post C. Effects of intrathecal injection of the adenosine receptor agonists R-phenylisopropyl-adenosine on nociception and motor function in the rat. Anesth.Analg. 1990;71;60-64. 2. Karlsten R, Post C, Hide I, Daly JW. The antinociceptive effect of intrathecally administered adenosine analogs in mice correlates with the affinity for the A1-adenosine receptor. Neurosci. Lett. 1991;121;267-270. 3. Karlsten R, Post C. Antinociceptive effect following peripheral administration of adenosine analogs

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Curriculum vitae

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in the formalin test in mice. Nucleosides & Nucleotides 1991;10;1131-1133. 4. Karlsten R, Gordh T, Post C. Local antinociceptive and hyperalgesic effects in the formalin test following peripheral administration of adenosine analogs in mice. Pharmacol. Toxicol. 1992;70;434438. 5. Karlsten R, Hartvig P. High incidence of cough after intravenous injection of ketobemidone (Ketogan®) in obstetric patients. Acta Anaesth. Scan. 1992;36;193-194. 6. Karlsten R, Kristensen JD, Gordh T. R-phenylisopropyl-adenosine increases spinal cord blood flow after intrathecal injection in the rat. Anesth. Analg. 1992;75;972-976. 7. Karlsten R, Englesson S. An alternative method of increasing PCO2 using apnea and continuous positive airway pressure. Br. J. Anaesth. 1993;70:411-413. 8. Karlsten R, Kristensen JD. Nitrous oxide does not influence the surgeons rating of operating conditions in lower abdominal surgery. Eur. J.Anaesth. 1993;10:215-217. 9. Kristensen JD, Karlsten R, Gordh T. Laser-Doppler evaluation of spinal cord blood flow after intrathecal administration of an NMDA antagonist in rats. Anesth. Analg. 1994;78:925-931. 10. Karlsten R, Gordh T, Svensson BA. A neurotoxical evaluation of the spinal cord after chronic intrathecal injection of R-phenylisopropyl-adenosine (R-PIA) in the rat. Anesth. Analg. 1993;77:731736. 11. Svensson BA, Karlsten R, Kristensen JD, Sottile A, Bennett A, Gordh T. Intrathecal injection of lycine acetylsalicylic acid in the rat - a neurotoxicological study. Acta Anaesth. Scan. 1993;37:799-805. 12. Kristensen JD, Karlsten R, Gordh T, Holtz A. Spinal cord blood flow after intrathecal injection of a N-methyl-D-aspartate receptor antagonist or an adenosine receptor agonist in rats. Anesth. Analg. 1993;76:1279-1283. 13. Kristensen JD, Karlsten R, Gordh T, Berge O-G. The NMDA antagonist 3-(2-carboxypiperazin-4yl)propyl-1-phosphonic acid (CPP) has antinociceptive effect after intrathecal injection in the rat. Pain. 1994;56:59-68. 14. Karlsten R, Gordh T. An A1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. Anesth. Analg. 1995;80:844-7. 15. Gordh T, Karlsten R, Kristensen JD. Intervention with spinal NMDA-, adenosine-, and NO-systems for pain modulation - implications for postoperative pain treatment. Annals of Medicine 1995;27:22934. 16. Hartvig P, Valtysson J, Lindner KJ, Kristensen J, Karlsten R, Gustafsson LL, Persson J, Svensson JO, Oye I, Antoni G, Westerberg G, Långström B. Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers. Clin. Pharmacol.Ther. 1995;58:165-173. 17. Sandberg J-O, Margulis B, Jansson L, Karlsten R, Korsgren O. Transplantation of fetal porcine pancreas to diabetic or normoglycemic nude mice. Transplantation 1995;59:1665-9. 18. Kristensen JD, Hartvig P, Karlsten R, Gordh T. CSF and plasma pharmacokinetics of the NMDA receptor antagonist CPP following intrathecal, epidural and intravenous administration. Br. J. Anaesth 1995;74:193-200. 19. Kristensen J, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine: A screening for neurotoxic effects. Anesth Analg 1996;82:636-640. 20. Korsgren O, Karlsten R, Sundler F, Jansson L. Blood flow regulation in the transplanted fetal endocrine pancreas: acquisition of a nitric oxide dependent glucose-induced increase in blood flow. Transplantation 1996;61:772-777. 21. Karlsten R, Mattson M-O, Lind L. Olika prioritetsgrader vid ambulanstransporter - alla behöver hög kompetens. Läkartidningen 1997; 94:1920-1921. 22. Karlsten R, Gordh T. How do drugs relieve neurogenic pain? Drugs & Aging 1997;11:398-412. 23. Kristensen J, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine and bupivacaine with or without epinephrine in rats. Acta Anaesthesiol. Scan. 1998;42:685-690. 24. Rane K, Karlsten R, Svensson BA, Sollevi A, Gordh T. Spinal cord morphology after chronic intrathecal administration of adenosine in the rat. Acta Anaesth. Scand. 1999;43:1035-1040. 25. Karlsten R, Gordh T, Ask A-L, Svensson BA. Sameridine - intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow. Acta Anaesthesiol. Scan. 1999;43:573-579. 26. Karlsten R, Sjöqvist BA. Telemedicine and decision support in emergency ambulances. Telemedicine and Telecare. 2000;6:1-7.

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27. Sjöqvist B-A, Dellborg M, Karlsten R. Telemedicine and patient information management in prehospital and ambulance care. European Telemedicine 1998/99, 113-115. 28. Sjölund K-F, Belfrage M, Karlsten R, Segerdahl M, Arnér S, Gordh T, Sollevi A. Systemic adenosine infusion reduces tactile allodynia in neuropathic pain following peripheral nerve injury. A multi-center, placebo-controlled study. In Proceedings of the 9th World Congress on Pain, Progress in pain research and management. Eds Devor M, Rowbotham M, Wiesenfeld-Hallin Z. IASP Press, Seattle 2000. 29. Karlsten R, Gordh T. The role of adenosine in the treatment of neuropathic pain. In Proceedings of the 9th World Congress on Pain, Progress in pain research and management. Eds Devor M, Rowbotham M, Wiesenfeld-Hallin Z. IASP Press, Seattle 2000. 30. Karlsten R. Lovande samarbete med räddningstjänten vid akutlarm. Läkartidningen 2000;97:1423-4. 31. Karlsten R, Gordh T. Adenosine – a new analgestic for the treatment of neuropathic pain? Eds Rowbotham MC, Malmberg A. IASP Newsletters 2000;1:3-6. 32. Meyerson J, Thelin S, Gordh T, Karlsten R. The incidence of chronic poststernotomy pain after cardiac surgery - a prospective study. Acta Anaesthesiol. Scan. 2001;45:940-44. 33. Karlsten R. Tidig defibrillering i väntan på ambulans – 2 års erfarenheter från samverkan med räddningstjänsten i Uppsala län. Scand J Trauma Emerg Med. 2001;9:108-12. 34. Sjölund K-F, Belfrage M, Karlsten R, Segerdahl M, Arnér S, Gordh T, Sollevi A. Systemic adenosine infusion reduces tactile allodynia in neuropathic pain following peripheral nerve injury. A multi-center, placebo-controlled study. Eur J Pain. 2001;5:199-207. 35. Benger J, Karlsten R, Eriksson B. Prehospital thromolysis – experiences from Sweden and implications for the UK. Emerg Med J. 2002;19:578-583. 36. Kvarnström A, Karlsten R, Quiding H, Emanuelsson B-M, Gordh T. The effectivness of intravenous ketamine and lidocaine on peripheral neuropathic pain. Acta Anaesthesiol Scand. 2003;47:868-877. 37. Kvarnström A, Karlsten R, Quiding H, Gordh T. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiol Scand. 2004;48:498-506. 38. Karlsten R, Elowsson P. Who calls for the ambulance: implications for decision support. A descriptive study from a Swedish dispatch centre. Eur J Emerg Med. 2004 ;11:125-129. 39. Rane K, Segerdahl M, Karlsten R. Intrathecal adenosine increases spinal cord blood flow in the rat. Measurements with laser-Doppler Flowmetry technique. Acta Anaesthesiol Scand. 2004;48:124955. 40. Rubertsson S, Karlsten R. Increased cortical cerebral blood flow with LUCAS; a new device for mechanical chest compressions as compared to standard external compressions during experimental cardiopulmonary resuscitation. Resuscitation, 2005 ;65:357-63. 41. Karlsten R, Ström K, Gunningberg L. Improving assessment of postoperative pain at surgical wards by education and training. Qual Saf Health Care. 2005 Oct;14:332-5. 42. Castrén M, Karlsten R, Lippert F, Christensen EF, Bovim E, Kvam AM, Robertson-Steel I, Overton J, Kraft T, Engerström L, Garcia-Castrill Riego L. Recommended guidelines for reporting on emergency medical dispatch when conducting research in emergency medicine: the Utstein style. Resuscitation, 2008;79:193-7. 43. What makes a chronic pain patient? Kieseritzky J, Kalliomäki M, Gordh T, Hägglöf B, Karlsten R, Rice F, Schmidt R, Sjögren N, Wiig M, Schmelz M. Scand J Pain 2009;1 DOI:101016/S18778860(09)70026-6 44. Wesnes K, Annas P, Edgar C, Deeprose C, Karlsten R, Philipp A, Kalliomäki J, Segerdahl M. Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers. J Psychopharmacol. 2010 Nov;24(11):1659-69. 45. Lindström V, Karlsten R, Falk AC, Castrèn M. Feasibility of a computer-assisted feedback system between dispatch centre and ambulances. Eur J Emerg Med. 2011 Feb 19. [Epub ahead of print). 46. Blomberg H, Gedeborg R, Berglund L, Karlsten R, Johansson J. Poor chest compression quality with mechanical compressions in simulated cardiopulmonary resuscitation: a randomized, cross-over minikin study. Resuscitation. 2011 Oct;82(10):1332-7. Epub 2011 Jun 15. 47. Kalliomäki M, Kieseritzky JV, Schmidt R, Hägglöf B, Karlsten R, Sjögren N, Albrecht P, Gee L, Rice F, Wiig M, Schmelz M, Gordh T. Structural and functional differences between neuropathy with and without pain? Experimental Neurology 2011;231(2):199-206. 48. Castrén M, Bohm K, Kvam AM, Bovim E, Christensen EF, Steen-Hansen JE, Karlsten R.

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Reporting of data from out-of-hospital cardiac arrest has to involve emergency medical dispatching-taking the recommendations on reporting OHCA the Utstein style a step further. Resuscitation. 2011 Dec;82(12):1496-500. Epub 2011 Sep 10. 49. Kalliomäki J, Philipp A, Baxendale J, Annas P, Karlsten R, Segerdahl M. Lack of effect by CNS active doses of nabilone on capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2012 Jan 10. doi: 10.1111/j.1440-1681.2012.05674.x. [Epub ahead of print] 50. Johansson J, Blomberg H, Svennblad B, Wernroth L, Melhus H, Byberg L, Michaelsson K, Karlsten R, Gedeborg R. Prehospital Trauma Life Support (PHTLS) training of ambulance caregivers and impact on survival of trauma victims. Resuscitation. 2012 Feb 23. [Epub ahead of print] 51. Kalliomäki J, Miller F, Kågedal M, Karlsten R. Early phase drug development for treatment of chronic pain — Options for clinical trial and program design. Contemporary Clinical Trials 2012 Feb 29. [Epub ahead of print}. 52. Rubertsson S, Silfverstolpe J, Rehn L, Nyman T, Lichtveld R, Boomars R, Bruins W, Ahlstedt B, Puggioli H, Lindgren E, Smekal D, Skoog G, Kastberg R, Lindblad A, Halliwell D, Box M, Arnwald F, Hardig BM, Chamberlain D, Herlitz J, Karlsten R. The study protocol for the LINC (LUCAS in cardiac arrest) study: a study comparing conventional adult out-of-hospital cardiopulmonary resuscitation with a concept with mechanical chest compressions and simultaneous defibrillation. Scand J Trauma Resusc Emerg Med. 2013 Jan 25;21:5. doi: 10.1186/1757-7241-21-5. 53. Kalliomäki J, Annas P, Huizar K, Clarke C, Zettergren A, Karlsten R, Segerdahl M. Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):212-8. doi: 10.1111/1440-1681.12051. 54. Kalliomäki J, Segerdahl M, Webster L, Reimfelt A, Huizar K, Annas P, Karlsten R, Quiding H. Evaluation of the analgesic efficacy of AZD1940, a novel cannabinioid agonist, on post-operative pain after lower third molar surgical removal. Scand J Pain 2013;4:17-22. 55. Quiding H, Jonzon B, Svensson O, Webster L, Reimfelt A, Karin A, Karlsten R, Segerdahl M. TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction. Pain. 2013 Jun;154(6):808-12. doi: 10.1016/j.pain.2013.02.004. Epub 2013 Feb 19. 56. Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, Halliwell D, Box M, Herlitz J, Karlsten R. Mechanical chest compressions and simultaneous defibrillation vs conventional cardiopulmonary resuscitation in out-ofhospital cardiac arrest: the LINC randomized trial. JAMA. 2014 Jan 1;311(1):53-61. doi: 10.1001/jama.2013.282538. Projects

Projects (national and international) 1. Telemedicin för utökad integrering och samverkan inom ambulans och akutsjukvården. NUTEK, 1994-1995. 2. MOBICARE - Strategy definition for Promoting Mobile Health Care Telematic Services in Europe. Project Number: A-2124. EU-project. 3. Mobil telemedicin inom ambulanssjukvården. NUTEK 1997-98. 4. HECTOR - Health Emergency Management and Coordination Through Telematics Operational Resources. (EU-project). 1996-1999. 5. Utveckling av mobil telemedicin i syfte att införa åtgärdshandledning och beslutstöd för prehospital personal verksam i ambulanssjukvården samt att möjliggöra säkrare ordinationer till mobila enheter från läkare baserade på sjukvårdsinrättningar. KK-stiftelsen. 1998-2000.

Memberships

Memberships: Swedish Medical association International Association for the study of pain (IASP) Swedish pain society Presentations at scientific meetings: 1. Karlsten R, Gordh T. Adenosinanaloger för modulering av smärta: En djurexperimentell utvärdering. Vid Svensk förening för anestesi och intensivvård, höstmöte 25-27 september 1991. 2. Karlsten R, Svensson BS, Gordh T. Evaluation of adenosine derivatives for modulation of pain: An experimental study in the rat. At: Highlights in regional anesthesia and pain therapy, XIth annual

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congress of the european society of regional anaesthesia, Brussels, June 1992. 3. Karlsten R, Kristensen JD, Gordh T. Spinal administration of CPP and R-PIA, preliminary toxicological and clinical studies - possible role in treatment of neuropatic pain. 11th Congress of Polish Society of Anaesthesiology and Intensive Therapy. Wroclaw, september 1993. 4. Lindecrantz K, Dellborg M, Karlsten R, Sjöqvist BA. AIM-projektet EPIC: European Prototype for Integrated Care. Svenska Läkaresällskapets Riksstämma, 2 december 1994. 5. Karlsten R. Telemedicin för utökad integrering och samverkan inom ambulans och akutsjukvården. NUTEKs Medicintekniska Konferens 1995. Linköping, 5-6 april 1995. 6. Karlsten R. Multitrauma - akut omhändertagande och optimala transportförutsättningar - hur minskar man risken för framtida ohälsa i väntan på storsjukhusets resurser. 9:e Nordiska Kongressen i Allmänmedicin. Uppsala, 19-22 juni 1995. 7. Karlsten, R. HECTOR i Uppsala läns landsting. Svensk Katastrofmedicinsk Förening. Lökeberg, 29-30 maj 1997. 8. Karlsten, R. Prehospital telemedicin. Trauma -97. SU-sjukhuset, Göteborg, 31 oktober 1997. 9. Karlsten R. The Injury Inventory System: use of mobile telematics in prehospital management of health emergencies. 1st International conference on health emergency telematics. Sevilla 15-17 mars 1999. 10. Karlsten R. Adenosine for pain treatment – data from animal experiments. IX World Congress on pain, Vienna, August 1999. 11. Karlsten R. Telemedicine and decision support in emergency ambulances in Uppsala. International Symposium on Telemedicine, Gothenburg, June 27-July 1, 2000. 12. Karlsten R. Erfarenheter från räddningstjänsten. 5:e Scaninaviska HLR-kongressen. Göteborg maj 2001. 13. Karlsten R. Utvärdering av larmsamtal. 5:e Skandinaviska HLR-kongressen. Göteborg maj 2001. 14. Karlsten R. Prehospital thrombolysis and decision support in emergency ambulances in Uppsala – Experiences using mobile telematics. 6th International conference on the medical aspects of telemedicine. Uppsala, June 18-21, 2001. 15. Karlsten R. Neuropathic pain: new analgesic drug targets NMDA and adenosine. Euroanaesthesia 2002. Nice 6-9 April 2002. 16. Karlsten R. Management and organization of postoperative pain. The fifth UAE conference of anaesthesia, critical care and pain medicine. Dubai, January 22-24, 2003. 17. Karlsten R. Adenosine as a novel analgesic for the treatment of neuropathic pain. The fifth UAE conference of anaesthesia, critical care and pain medicine. Dubai, January 22-24, 2003. 18. Karlsten R. Att lindra smärta – en viktig multidisciplinary angelägenhet I vården. Svenska läkaresällskapet. February 25. 2003. 19. Karlsten R. IVPA – erfarenheter från Uppsala län. Södersjukhuset, Stockholm. April 21, 2004. 20. Karlsten, R. The Complexity of Chronic Neuropathic Pain: A Challenge and an Opportunity in Clinical Trials. Clinical development for chronic pain Therapeutics. Amsterdam. March 29-30, 2007. 21. Karlsten, R. Outcome of pharmacological treatment in neuropathic pain. 4th Annual Pain Management Conference. London, October 31- November 2, 2007. 22. Karlsten, R. Outcome of treatment in neuropathic pain – implication for drug development and study design. SMi’s 9th Annual Pain Therapeutics Conference. London, June 9-10 2008. 23. Karlsten, R. Improving clinical post-operative and musculosceletal pain treatment. 6th James Black Conference. New pain concepts & future treatments. St Andrews, August 16-17, 2008. 24. Karlsten, R. Prehospital utveckling och organisation. SFAI, Uppsala, September 10-12, 2008. 25. Karlsten, R. Outcome of treatment in neuropathic pain in clinical practice – its implication for drug development and study design. 6th Annual Pain Management Conference. London, October 14-15, 2009. 26. Karlsten R. Early phase development of medicines for treatment of chronic pain - some options for clinical trial and program design. 8th Annual Pain Management Conference. London July 4-5, 2011. 27. Karlsten R. TRPVI from mouse to man. Läkemedelskongressen. Stockholm, November 12-13 2013. 28. Karlsten R. Behandling av långvarig nociceptiv smärta. Läkemedelskongressen. Stockholm, November 12-13, 2013.

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Other Relevant Information

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