OIE Regional Workshop on Enhancing Influenza A Viruses National Surveillance, Tokyo, Japan, August 26-28, 2014

H5N1 avian influenza vaccination in China Hualan Chen Harbin Veterinary Research Institute, CAAS

The most important poultry disease • Resulting in the death or culling of over 250 million poultry and wild birds • Involved multiple countries; infected wild birds • Endemic in several developing countries— impossible to control the disease by “stamping out”

Vaccination is an alternative • Oil adjuvant inactivated vaccines: the naturally isolated low pathogenic virus or attenuated highgrowth virus generated by reverse genetics as seed strains • Live virus-vectored vaccines: Recombinant fowlpox virus, recombinant Newcastle disease virus

HA 2009-2012 19962009

Clade 2.3.2.1

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2);

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2); Re-7 (CK/LN/11, clade 7.2)

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2); Re-7 (CK/LN/11, clade 7.2) Re-1

2004

2008

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2); Re-7 (CK/LN/11, clade 7.2) Re-1

2004

Re-5

2008

2012

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2); Re-7 (CK/LN/11, clade 7.2) Re-1

2004

Re-5

2008

Re-6

2012

Challenge 1 • Frequently antigenic variation of the field strains requests timely update of the vaccine seed virus • Re-1 (GS/GD/96, clade 0); Re-4 (CK/SX/06, calde 7.2); Re5 (DK/AH/06, clade 2.3.4); Re-6 (DK/GD/12, clade 2.3.2); Re-7 (CK/LN/11, clade 7.2) Re-1

2004

2006

Re-5

2008

Re-6

2012 Re-4

2012 Re-7

Over 100 billions doses have been used in China, Vietnam, Indonesia, Egypt, and several other countries

Challenge 2 • Vaccination coverage rate is difficult to reach to the level (>70%) that is required for the national population immunity

Challenge 2 • Vaccination coverage rate is difficult to reach to the level (>70%) that is required for the national population immunity

Species

Breeder chickens and layers

Rough amount

4-5 billions

Vaccination coverage rate

>80%

Challenge 2 • Vaccination coverage rate is difficult to reach to the level (>70%) that is required for the national population immunity

Species

Breeder chickens and layers

Waterfowl s (ducks)

Rough amount

4-5 billions

4 billions

Vaccination coverage rate

>80%

70%) that is required for the national population immunity

Species

Breeder chickens and layers

Waterfowl s (ducks)

Broilers

Rough amount

4-5 billions

4 billions

8 billions

Vaccination coverage rate

>80%

80%

80%

>80%

70%) that is required for the national population immunity

Species

Breeder chickens Waterfowls and layers (ducks)

Broilers

Rough amount

4-5 billions

4 billions

8 billions

Vaccination coverage rate

>80%

>80%