Int. J. Cancer: 116, 972–983 (2005) ' 2005 Wiley-Liss, Inc.

Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population Li-Na Mu1, Qing-Yi Lu2, Shun-Zhang Yu1, Qing-Wu Jiang1, Wei Cao3, Nai-Chieh You3, Veronica Wendy Setiawan3, Xue-Fu Zhou4, Bao-Guo Ding4, Ru-Hong Wang4, Jinkou Zhao5, Lin Cai6, Jian-Yu Rao7, David Heber2 and Zuo-Feng Zhang3* 1 Department of Epidemiology, Fudan University School of Public Health, Shanghai, China 2 UCLA Center for Human Nutrition, School of Medicine, Los Angeles, CA, USA 3 Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA 4 Taixing City Center for Disease Prevention and Control (CDC), Taixing, Jiangsu, China 5 Department of Chronic Disease Prevention, Jiangsu CDC, Nanjing, Jiangsu, China 6 Department of Epidemiology, Fujian Medical University, Fuzhou, Fujian, China 7 Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA The purpose of our study was to examine the roles of green tea drinking, other risk and protective factors, and polymorphism of susceptibility genes such as GSTM1, GSTT1, GSTP1, and p53 codon 72 and their possible joint effects on the risk of stomach cancer. A population-based case-control study was conducted in Taixing, China, including 206 newly diagnosed cases with stomach cancer and 415 healthy control subjects. Epidemiological data were collected by in-person interviews using a standard questionnaire. Polymorphisms of susceptibility genes were assayed by PCR-RFLP techniques. A multigenetic index was created by summing up the number of risk genotypes. The data were analyzed using the logistic regression model. A reverse association between green tea drinking and risk of stomach cancer was observed with an adjusted odds ratio (OR) of 0.59 (95% confidence interval [CI] 5 0.34–1.01). Dose-response relationship was shown (p-trend < 0.05). A higher score on the multigenetic index was associated with increased risk of stomach cancer with an adjusted OR of 2.21 (95% CI 5 1.02–4.79) for those with at least 3 risk genotypes compared to those with