1 Raul D. Santos MD, MSc, PhD (Raul Dias dos Santos Filho) Director Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medical School Hospital Associate Professor Discipline of Cardiology The University of Sao Paulo Medical School Sao Paulo Brazil

Birth: September 26, 1963 at São Paulo, SP- Brazil Home Address: Rua Peixoto Gomide 1526, ap.13 São Paulo-SP CEP 01409-002, Brazil Phone/ FAX+5511-30630779 Professional Address: Unidade Clínica de Lipides - Instituto do Coração (InCor)-HCFMUSP (Lipid Clinic- Heart Institute University of São Paulo Medical School Hospital) Av. Dr Enéas C Aguiar, 44 Segundo Andar 05403-000 São Paulo, Brazil Phone/fax- 5511-20615320 e-mail- [email protected] ; [email protected]

Graduation and post-graduation training and education Graduation: Escola Paulista de Medicina -Federal University of Sao Paulo 1986 Medical Residency – University of São Paulo Medical School Hospital 1987-1990 (internal medicine and cardiology) Clinical Fellowship- Coronary Care Unit – Heart Institute University of Sao Paulo Medical School Hospital 1990-1992 Master in the sciences degree: in food sciences/experimental nutrition Faculty of Pharmaceutical Sciences University of Sao Paulo, 1995 PhD degree- in food sciences/experimental nutrition Faculty of Pharmaceutical Sciences University of Sao Paulo, 1999

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Certifications: Specialist in cardiology by the Brazilian Society of Cardiology Approved in the Educational Commission for Foreign Medical Graduates USA in basic and clinical sciences and in the English proficiency test.

Current Position •

Director –Lipid Clinic of The Heart Institute (InCor) of the University of Sao Paulo Medical School Hospital (HCFMUSP), Sao Paulo-Brazil.

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Associate Professor Discipline of Cardiology the University of Sao Paulo Medical School

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Member of the preventive council of Society of Atherosclerosis Imaging and Prevention

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Associate Editor Atherosclerosis

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Associate Editor Journal of Clinical Lipidology

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Editorial board member Endocrine

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Secretary - International Atherosclerosis Society 2012-2015

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Member of the consulting board International Familial Hypercholesterolemia Foundation

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Vice President Ibero-American Familial Hypercholesterolemia Network

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Member of the European Atherosclerosis Society Consensus Panel

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Scientific Advisor Preventive Medicine Center Albert Einstein Hospital Sao Paulo, Brazil

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Reviewer for the following journals: Atherosclerosis, The American Journal of Cardiology, The American Journal of Cardiovascular Drugs, The Anatolian Journal of Cardiology, Annals of Medicine, Archives of Internal Medicine, Arteriosclerosis Thrombosis and Vascular Biology, BMJ point of care, BMJ, Cardiology, Cardiovascular Research, Coronary Artery Disease, Clinical Journal of The American Society of Nephrology, Heart, The International Journal of Cardiology, Journal of the American Society of Nephrology , Journal of The American College of Cardiology, Journal of Human Hypertension, Journal of Rheumatology, Journal of Clinical Lipidology, PlosOne, Revista de Saúde Pública, Arquivos Brasileiros de Cardiologia, Revista de Nutrição, Brazilian Journal of Biological and Medical Research .

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Add hoc consultant: São Paulo Research Foundation (FAPESP), Health Research Council of New Zealand, The American College of Cardiology, Research Grants Council Hong Kong, International Atherosclerosis Society, South Africa’s National Research Foundation (NRF) and Swiss National Science Foundation.

Former Positions • • •

Member at large of the Americas- International Atherosclerosis Society 2010-2012 President of the Department of Atherosclerosis of The Brazilian Society of Cardiology 2010-2011 Scientific Director of the Department of Atherosclerosis of The Brazilian Society of Cardiology 2008-2009

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Scientific Director of the Department of Atherosclerosis of The Brazilian Society of Cardiology 2001-2003.

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Vice-president of the Department of Atherosclerosis of The Brazilian Society of Cardiology 1999-2001.

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Treasurer of the São Paulo Society of Cardiology (SOCESP) 2010-2011

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Scientific Director of the Brazilian Heart Foundation 2001-2003

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Coordinator of the III Brazilian Guidelines on Prevention of Atherosclerosis of the Department of Atherosclerosis of The Brazilian Society of Cardiology 2001.

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Assistant Physician of The Coronary Care Unit of the Sirio Libanes Hospital São Paulo Brazil since 1994-2003.

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President of the Executive Committee of the Latin American Task Force for Prevention of Coronary Heart Disease 2007-2008

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Coordinator of the Cardiovascular Disease Preventive Program of the Preventive Medicine Center of the Albert Einstein Hospital Sao Paulo-Brazil from 2002

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Director of the Metabolic Syndrome Committee of the Interamerican Heart Foundation 2002-2005

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Member of the Executive Committee of the International Lipids and Information Bureau (ILIB) Brazil 2000-2006

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Member of the Editorial Board of the Revista da Associação Médica Brasileira (Journal of The Brazilian Medical Association) 2002-2005

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Publications Pubmed: Santos RD, Raul Santos, and Santos Filho RD 2014 Lipoprotein(a) and cardiovascular disease in heterozygous familial hypercholesterolemia should we also blame the LDL receptor? Santos RD. J Am Coll Cardiol 2014 in press What is new in familial hypercholesterolemia? Santos RD, Maranhao RC. Curr Op Lipidol 2014 in press Testosterone: A vascular hormone? Commentary on the study of Vlachopoulos et al. Gebara OC, Santos RD. Atherosclerosis. 2014;233:559-560 Relation Between Self-Reported Physical Activity Level, Fitness, and Cardiometabolic Risk Minder Cm, Shaya GE, Michos ED, Keenan TE , Blumenthal RS, Nasir K, Carvalho JAM, Conceição RD, Santos RD, Blaha MJ. Am J Cardiol 2014 ;113:637-43 Association between postprandial triglycerides and coronary artery disease detected by coronary computed tomography angiography. Staniak HL, Salgado Filho W, Miname MH, Benseñor IM, Lotufo PA, Sharovsky R, Rochitte CE, Bittencourt MS, Santos RD. Atherosclerosis. 2014 ;233:381-386. . Statin Use Is Not Associated With Presence of and Severity of Nonalcoholic Fatty Liver Disease. Oni ET, Sinha P, Karim A, Martin SS, Blaha MJ, Agatston AA, Blumenthal RS, Meneghelo RS, Conceiçao RD, Santos RD, Nasir K. Arch Med Res 2014;45:52-7 Presence and type of low density lipoprotein receptor (LDLR) mutation influences the lipid profile and response to lipid-lowering therapy in Brazilian patients with heterozygous familial hypercholesterolemia. Santos PC, Morgan AC, Jannes CE, Turolla L, Krieger JE, Santos RD, Pereira AC. Atherosclerosis. 2014;233:206-10.

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An International Atherosclerosis Society Position Paper: Global recommendations for the management of dyslipidemia-Full report. Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members. J Clin Lipidol. 2014 ;8:29-60. Favorable effects of ezetimibe alone or in association with simvastatin on the removal from plasma of chylomicrons in coronary heart disease subjects. Mangili OC, Moron Gagliardi AC, Mangili LC, Mesquita CH, Machado Cesar LA, Tanaka A, Schaefer EJ, Maranhão RC, Santos RD. Atherosclerosis. 2014;233:319-25. An International Atherosclerosis Society Position Paper: Global recommendations for the management of dyslipidemia: Executive summary. Expert Panel on Dyslipidemia. Atherosclerosis. 2014 ;232:410-3. Residual macrovascular risk in 2013: what have we learned? Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, Gotto AM Jr, Hu D, Kadowaki T, Kodama T, Krempf M, Matsuzawa Y, Núñez-Cortés JM, Monfil CC, Ogawa H, Plutzky J, Rader DJ, Sadikot S, Santos RD, Shlyakhto E, Sritara P, Sy R, Tall A, Tan CE, Tokgözoğlu L, Toth PP, Valensi P, Wanner C, Zambon A, Zhu J, Zimmet P; Residual Risk Reduction Initiative (R3i). Cardiovasc Diabetol. 2014 Jan 24;13:26. doi: 10.1186/1475-2840-13-26.

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJ, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJ. Int J Cardiol. 2014;171:309-25. Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review. Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K. BMC Public Health. 2014 Jan 8;14:14.

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2013 Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension. Santos RD, Duell PB, East C, Guyton JR, Moriarty PM, Chin W, Mittleman RS. Eur Heart J. first published online December 23, 2013 doi:10.1093/eurheartj/eht508 The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, Borén J, Bruckert E, Catapano A, Descamps OS, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Stroes E, Taskinen MR, Anne Tybjærg-Hansen A, Watts GW, Wiklund O, on behalf of the European Atherosclerosis Society Consensus Panel Lancet Diabetes & Endocrinology, Early Online Publication, 23 December 2013 doi:10.1016/S2213-8587(13)70191

Validating the benefits of lipid modifying therapies upon atherosclerotic plaque by computed tomography angiography: Should we trust our eyes? Commentary on the study of Zeb et al. Rached FH, Santos RD. Atherosclerosis. 2013;231:189-90. Relevance of prehypertension as a diagnostic category in asymptomatic adults. Nary FC, Santos RD, Laurinavicius AG, Conceição RD, de Carvalho JA. Einstein (Sao Paulo). 2013 ;11:303-9. Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia. Brasileiro-Santos MS, Barreto-Filho JA, Santos RD, Chacra AP, Sangaleti CT, Alvez G, Bezerra OC, Bortoloto LA, Irigoyen MC, Consolim-Colombo FM. Eur J Clin Invest. 2013;43:1291-8. A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care? Oni ET, Agatston AS, Blaha MJ, Fialkow J, Cury R, Sposito A, Erbel R, Blankstein R, Feldman T, Al-Mallah MH, Santos RD, Budoff MJ, Nasir K. Atherosclerosis. 2013;230:258-67. Relation of Hepatic Steatosis to Atherogenic Dyslipidemia.

7 Makadia SS, Blaha M, Keenan T, Ndumele C, Jones S, Defilippis A, Martin S, Kohli P, Conceicao R, Carvalho J, Nasir K, Blumenthal R, Santos RD. Am J Cardiol. 2013;112:1599-604 Delayed Heart Rate Recovery is Strongly Associated With Early and Late-Stage Prehypertension During Exercise Stress Testing. Aneni E, Roberson LL, Shaharyar S, Blaha MJ, Agatston AA, Blumenthal RS, Meneghelo RS, Conceiçao RD, Nasir K, Santos RD. Am J Hypertens. 2013 Sep 16. [Epub ahead of print]

C-reactive protein is independently associated with coronary atherosclerosis burden among octogenarians. Quaglia LA, Freitas WM, Soares AA, Santos RD, Nadruz W Jr, Blaha M, Coelho OR, Blumenthal R, Agatston A, Nasir K, Sposito AC. Aging Clin Exp Res. 2013 Aug 20. [Epub ahead of print] PMID: 23959959 Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A; for the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2013;34:3478-90 Is there a consistent association between coronary heart disease and ischemic stroke caused by intracranial atherosclerosis? Conforto AB, Leite Cda C, Nomura CH, Bor-SengShu E, Santos RD. Arq Neuropsiquiatr. 2013 May;71(5):320-6. . Guidance on the consumption of fats and cardiovascular health Santos RD, Gagliardi AC, Xavier HT, Magnoni CD, Cassani R, Lottenberg AM. Arq Bras Cardiol. 2013 Jan;100(1 Suppl 3):1-40. Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand? Pandey AK, Pandey S, Blaha MJ, Agatston A, Feldman T, Ozner M, Santos RD, Budoff MJ, Blumenthal RS, Nasir K. Atherosclerosis. 2013;228(2):285-94. Lipid-lowering treatment for homozygous familial hypercholesterolaemia.

8 Santos RD. Lancet. 2013;381(9873):1182. Brazilian guidelines on Familial Hypercholesterolemia. Santos RD, Gagliardi AC, Xavier HT, Casella Filho A, Araújo DB, Cesena FY, Alves RJ. Arq Bras Cardiol. 2012 99(2 Suppl 2):1-28. Transfer of lipids to high-density lipoprotein (HDL) is altered in patients with familial hypercholesterolemia. Martinez LR, Santos RD, Miname MH, Deus DF, Lima ES, Maranhão RC. Metabolism. 2013 ;62(8):1061-4. Extensive xanthomas and severe subclinical atherosclerosis in homozygous familial hypercholesterolemia. Rocha VZ, Chacra AP, Salgado W, Miname M, Turolla L, Gagliardi AC, Ribeiro EE, Rocha RP, Avila LF, Pereira A, Nakandakare ER, Santos RD. J Am Coll Cardiol. 2013;61:2193. Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients. Carvalho AB, Carneiro R, Leme GM, Rochitte CE, Santos RD, Miname MH, Moyses RM, Jorgetti V, Canziani ME. J Bone Miner Metab. 2013 ;31:551-5. Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults. Vranian MN, Keenan T, Blaha MJ, Silverman MG, Michos ED, Minder CM, Blumenthal RS, Nasir K, Meneghelo RS, Santos RD. Am J Cardiol. 2013;111:991-5. Angiotensinogen gene polymorphism and HDL2 are linked to coronary artery calcification in individuals with family history of early coronary disease. Sposito AC, Santos RD. Atherosclerosis. 2013 ;226:339-40. Plaque regression measured by intravascular ultrasound and reduction of cardiovascular events: not yet the case, commentary on the study of D'Ascenzo et al. Rocha VZ, Santos RD. Atherosclerosis. 2013;226:45-6. Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis. Keenan T, Blaha MJ, Nasir K, Silverman MG, Tota-Maharaj R, Conceição RD, Carvalho JAM, Blumenthal RS, Santos RD. Am J Cardiol, 2012; 110:1787-92

9 The association between coronary artery calcification progression and loss of bone density in non-dialyzed CKD patients. Watanabe R, Lemos MM, Carvalho AB, Rochitte CE, Santos RD, Draibe SA, F Canziani ME. Clin Nephrol. 2012; 78:425-31

Non-alcoholic fatty liver disease and cardiovascular disease. Santos RD, Agewall S. Atherosclerosis. 2012 224(2):324-5 A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2. Santos RD, Waters DD, Tarasenko L, Messig M, Jukema JW, Chiang CW, Ferrieres J, Foody JM. Atherosclerosis. 2012;224:150-3 “Phosphorus Is Associated with Coronary Artery Disease in Patients with Preserved Renal Function". Cancela ALE, Santos RD, Titan SM, Goldenstein PT; Rochitte CE, Lemos PA; Reis LM; Graciolli FG; Jorgetti V, Moysés RM. PLoS One. 2012;7(5):e36883 “Elevated uric acid, the metabolic syndrome and cardiovascular disease: cause, consequence or just a not so innocent bystander?” Santos RD. Endocrine. 2012;41:350-2 “Comparison of Lipid Profiles and Attainment of Lipid Goals in Patients