Genomics for Drug Research and Development

Genomics for Drug Research and Development Cora Vacher Market Development Manager – Complex Diseases OCT 11, 2016 © 2016 Illumina, Inc. All rights re...
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Genomics for Drug Research and Development Cora Vacher Market Development Manager – Complex Diseases OCT 11, 2016

© 2016 Illumina, Inc. All rights reserved. Illumina, 24sure, BaseSpace, BeadArray, BlueFish, BlueFuse, BlueGnome, cBot, CSPro, CytoChip, DesignStudio, Epicentre, ForenSeq, Genetic Energy, GenomeStudio, GoldenGate, HiScan, HiSeq, HiSeq X, Infinium, iScan, iSelect, MiniSeq, MiSeq, MiSeqDx, MiSeq FGx, NeoPrep, NextBio, Nextera, NextSeq, Powered by Illumina, SureMDA, TruGenome, TruSeq, TruSight, Understand Your Genome, UYG, VeraCode, verifi, VeriSeq, the pumpkin orange color, and the streaming bases design are trademarks of Illumina, Inc. and/or its affiliate(s) in the US and/or other countries. All other names, logos, and other trademarks are the property of their respective owners.

Illumina Mission To advance human health by unlocking the power of the genome From Genome Wide Discovery…

To Targeted Validation and Beyond…

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Leading the Global Sequencing Presence

>90% 78,629 *Data calculations on file. Illumina, Inc., 2015 **Data calculations on file. Illumina, Inc., Q3 2016.

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of the world’s sequencing data is generated using Illumina SBS technology*

publications to date reference or use Illumina (excluding reviews)**

Illumina Platforms SEQUENCING SYSTEMS | Sequencing by Synthesis (SBS) POPULATION POWER

PRODUCTION POWER

FLEXIBLE POWER

NextSeq® 500/550

HiSeq® 4000

HiSeq X® Ten

HiSeq 3000

FOCUSED POWER

MiSeq®

HiSeq X Five

HiSeq 2500

MiSeqDx® For in vitro diagnostic use

ARRAY SCANNING | Infinium® MiSeq FGx™ CUTTING-EDGE ARRAY SCANNER

iScan®

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For Research Use Only. Not for use in diagnostic procedures.

MiniSeq™

Driving Discovery and Association Illumina genomic continuum

Explain and verify findings

Get statistical power for targeted variants

Custom arrays • Evaluate and validate variants • Deliver high-throughput screening

Explain and verify findings at largest scale

Next-generation sequencing • Identify novel variants • Provide targeted resequencing • Gene expression • Methylation

Get statistical power for novel variants

Arrays • Genotyping • Methylation

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For Research Use Only. Not for use in diagnostic procedures.

Custom arrays • Enable focused genotyping studies

Integrated approach for Drug Development Pipeline Illumina solution for the future of drug discovery DNA Analysis Target Identification

Oncology

RNA Analysis Target Validation

NextSeq, MiSeq

Preclinical Development

Instruments

HiSeq, HiSeqX Ten, NextSeq, iScan

NextSeq, MiSeq

Informatics

BaseSpace®, BaseSpace Onsite, NextBio® Research

GWAS Studies Infinium, iSelect®

Companion DX

Clinical Development Phase I Phase II Phase III

Post Approval

MiSeq, MiSeqDx

MiSeqDx

BaseSpace, BaseSpace Onsite, MSR, VariantStudio, Cohort Analyser/Correlation Engine (CA/CE)

MSR, VariantStudio, Cohort Analyser/Correlation Engine (CA/CE)

Candidate Genotyping iSelect®

Biomarker discovery Resequencing, de novo sequencing Transcriptome profiling RNA-Sequencing Gene Regulation microRNA

SNV Screening Exome and Custom re-sequencing (biomarker validation) Toxigenomics RNASequencing

Gene Expression Profiling RNA-Sequencing Companion Diagnostics DNA, RNA Single Target analysis

Gene Regulation Chip Seq, WG Methyl analysis

Oncology: Candidate Analysis Target resequencing, custom GTP, (biomarkers validation)

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For Research Use Only. Not for use in diagnostic procedures.

BioProcess Applications Overview of applications for biopharmaceutical QA/QC testing Cell line development and scale up

Bioreactor Production

Harvest, Recovery

Purification

Formulation

Release

RNA Analysis

DNA Analysis

Cell line characterization and monitoring, raw material testing Whole genome resequencing, Amplicon sequencing / HiSeq, MiSeq

Vector characterization Plasmid sequencing / HiSeq, MiSeq Sterility testing 16s Sequencing for microbial identification / MiSeq

Cell line characterization: gene expression RNA-Seq /HiSeq, MiSeq Virus detection – raw materials and cell lines RNA-Seq / HiSeq

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For Research Use Only. Not for use in diagnostic procedures.

Illumina’s range of Professional Care Services Illumina Concierge Custom Design Service Personalized consulting solution for customers who need assistance in the design and delivery of custom content for genomics projects.

Illumina FastTrack™ services portfolio of array and next-generation sequencing (NGS) services to support a broad range of genomic applications.

Illumina Bioinformatics Professional Services Accelerate your research with personalized consultations and hands-on training from Illumina experts. 8

Pharma: Value Proposition Solutions along the drug development cycle

Illumina

Value Prop

Target Identification

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Identify novel disease associations

GWAS/Arrays Exome Seq WGS, RNASeq

Drug Screening

Early Phase Trials

Alternative development for non-responders

GWAS/ Arrays Exome Seq WGS, Targeted Seq

Late Phase Trials

Reduce serious Adverse Drug Reactions

Market Surveillance

Favorable reimbursement / formulary position

Illumina IVD/CDx Partnerships & Development

Questions?

Cora Vacher, PhD Market Development Manager Complex Diseases

Carla Simoes Marketing Technical Specialist UK & Ireland

Eva Baker, Ph.D. Senior Territory Account Manager

Mobile: +44 7881 907192 Email: [email protected]

Mobile: +44 7780 449412 E-mail: [email protected]

Mobile:+ 44 7469 219455 E-mail: [email protected]

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