Additional Techniques Provide Enhanced Versatility
Waters: For Complete Confidence
Sales Offices:
The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometer
Waters Corporation is the world's leading provider of instruments, chemistries, software,
Austria 43 1 877 18 07
maximizes the amount of information that can be obtained across a wide range of sample types.
and support services for chromatography, mass spectrometry, thermal analysis and
Australia 61 2 9933 1777
laboratory informatics.
Belgium and Luxembourg
For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science. To learn more visit www.waters.com
32 2 726 1000 Brazil 55 11 5543 7788
GCT PREMIER MASS SPECTROMETER
Do You Need: • Wide dynamic range for characterization of complex mixtures?
Canada 800 252 4752 X2205
• Rapid spectral acquisition rates to profile narrow chromatographic peaks?
Czech Republic 420 2 617 11384
• Highly specific exact mass measurement for structural elucidation?
Denmark 45 46 59 8080
• Selectivity of high resolution to provide low determination limits?
Finland 358 9 506 4140 France 33 1 3048 7200 Germany 49 6196 400600
• High sensitivity full scan spectra to maximize sample information? • A comprehensive suite of post-processing software to maximize productivity and information output?
Hong Kong 852 29 64 1800 Hungary 36 1 350 5086 India 91 80 2837 1900 Ireland 353 1 448 1500
Take GC/MS to the Highest Level
Italy 39 02 27 4211
The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and
Japan 81 3 3471 7191
exact mass performance of the classic GCT™ with extended dynamic range. These unmatched
Figure 6. EI and CI are complementary techniques, providing
Figure 7. FI is the softest ionization technique for generating
Korea 82 2 820 2700
capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for
structural and molecular weight information.
molecular weight information on most compound types.
Mexico 52 55 5524 7636
full characterization and profiling of components in a whole range of sample types.
The Netherlands 31 76 508 7200 Norway 47 6 384 6050 People’s Republic of China 86 10 8451 8918 Poland 48 22 833 4400 Puerto Rico 787 747 8445
• Metabolomics
Russia/CIS 7 095 931 9193
• Metabonomics
Singapore 65 6278 7997
• Synthetics confirmation and QC
Spain 34 93 600 9300 Sweden 46 8 555 11 500
thermally labile compounds. The molecular ion can be seen at m/z 380.
• Natural products research
Switzerland 41 62 889 2030
• Pesticide residues monitoring
Taiwan 886 2 2543 1898
• Unknown environmental contaminants ID
UK 44 208 238 6100
• Food research and QC
US 800 252 4752
Figure 8. DCI is a softer alternative to solids probe CI for
Use the GCT Premier for Characterization and Profiling in the following Application Areas:
WATERS CORPORATION 34 Maple St. Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com
• Flavors and fragrances research and QC • Material emissions monitoring and research • Homeland security chemical monitoring • Polymer research • Petrochemicals • Materials research and monitoring
Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation. All other trademarks are property of their respective owners. ©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV
Waters Micromass GCT Premier Mass Spectrometer
Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform
Increase Productivity with Rapid Spectral Sampling and Acquisition Rate
The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data
Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)
with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood
The advantage of the full mass range spectra produced by the
spectral skew associated with scanning instruments, which means that accurate spectra and quantitative
of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over
GCT Premier enables a wide range of components, both known
data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate
traditional GC/MS.
and unknown, to be detected with high sensitivity. Full mass range
(up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters
spectra are beneficial when trying to characterize samples in terms
deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.
With the GCT Premier, your lab will benefit from:
of identity and quantity.
Compact Size: Powerful oa-TOF with reflectron technology
The extended dynamic range of the GCT Premier delivers up to four
The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the
orders of magnitude for exact mass measurement and quantitative
minimizing linear bench space without sacrificing performance
studies allowing you to maximize information produced from a
Elevated Resolution: 7000 FWHM
single analysis.
Exact Mass Measurement: Sub-5 ppm RMS with internal lock
Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear
mass correction
dynamic range with DRE enabled.
Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with
Figure 1. Proven oa-TOF technology in a compact bench top
traditional scanning instruments
GC/MS system.
High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)
Compound 1 thujopsene
GC and AutoSampler Control: Integrated control of
Agilent®
6890N GC and Agilent 7683, and CTC-GCPal™ and CTCCombiPal™ autosamplers ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components
Figure 2. Exact mass MS measurement enables compounds
in complex mixtures while enabling the comparison of sample
to be more easily identified. Confirming a measured m/z to
and control extracts
within 5 ppm significantly increases confidence in assigning
MarkerLynx™ db Application Manager: Dynamic statistical
elemental composition.
processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx™
Compound 2 fruitate
Compound 3 cyclamen aldehyde
Application Manager: Automated exact mass
processing for batch confirmation of synthetics
Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed
Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass
using ChromaLynx Application Manager.
Spectrometer as chromatographic intensity changes.
Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform
Increase Productivity with Rapid Spectral Sampling and Acquisition Rate
The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data
Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)
with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood
The advantage of the full mass range spectra produced by the
spectral skew associated with scanning instruments, which means that accurate spectra and quantitative
of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over
GCT Premier enables a wide range of components, both known
data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate
traditional GC/MS.
and unknown, to be detected with high sensitivity. Full mass range
(up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters
spectra are beneficial when trying to characterize samples in terms
deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.
With the GCT Premier, your lab will benefit from:
of identity and quantity.
Compact Size: Powerful oa-TOF with reflectron technology
The extended dynamic range of the GCT Premier delivers up to four
The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the
orders of magnitude for exact mass measurement and quantitative
minimizing linear bench space without sacrificing performance
studies allowing you to maximize information produced from a
Elevated Resolution: 7000 FWHM
single analysis.
Exact Mass Measurement: Sub-5 ppm RMS with internal lock
Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear
mass correction
dynamic range with DRE enabled.
Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with
Figure 1. Proven oa-TOF technology in a compact bench top
traditional scanning instruments
GC/MS system.
High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)
Compound 1 thujopsene
GC and AutoSampler Control: Integrated control of
Agilent®
6890N GC and Agilent 7683, and CTC-GCPal™ and CTCCombiPal™ autosamplers ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components
Figure 2. Exact mass MS measurement enables compounds
in complex mixtures while enabling the comparison of sample
to be more easily identified. Confirming a measured m/z to
and control extracts
within 5 ppm significantly increases confidence in assigning
MarkerLynx™ db Application Manager: Dynamic statistical
elemental composition.
processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx™
Compound 2 fruitate
Compound 3 cyclamen aldehyde
Application Manager: Automated exact mass
processing for batch confirmation of synthetics
Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed
Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass
using ChromaLynx Application Manager.
Spectrometer as chromatographic intensity changes.
Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform
Increase Productivity with Rapid Spectral Sampling and Acquisition Rate
The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data
Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)
with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood
The advantage of the full mass range spectra produced by the
spectral skew associated with scanning instruments, which means that accurate spectra and quantitative
of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over
GCT Premier enables a wide range of components, both known
data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate
traditional GC/MS.
and unknown, to be detected with high sensitivity. Full mass range
(up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters
spectra are beneficial when trying to characterize samples in terms
deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.
With the GCT Premier, your lab will benefit from:
of identity and quantity.
Compact Size: Powerful oa-TOF with reflectron technology
The extended dynamic range of the GCT Premier delivers up to four
The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the
orders of magnitude for exact mass measurement and quantitative
minimizing linear bench space without sacrificing performance
studies allowing you to maximize information produced from a
Elevated Resolution: 7000 FWHM
single analysis.
Exact Mass Measurement: Sub-5 ppm RMS with internal lock
Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear
mass correction
dynamic range with DRE enabled.
Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with
Figure 1. Proven oa-TOF technology in a compact bench top
traditional scanning instruments
GC/MS system.
High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)
Compound 1 thujopsene
GC and AutoSampler Control: Integrated control of
Agilent®
6890N GC and Agilent 7683, and CTC-GCPal™ and CTCCombiPal™ autosamplers ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components
Figure 2. Exact mass MS measurement enables compounds
in complex mixtures while enabling the comparison of sample
to be more easily identified. Confirming a measured m/z to
and control extracts
within 5 ppm significantly increases confidence in assigning
MarkerLynx™ db Application Manager: Dynamic statistical
elemental composition.
processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx™
Compound 2 fruitate
Compound 3 cyclamen aldehyde
Application Manager: Automated exact mass
processing for batch confirmation of synthetics
Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed
Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass
using ChromaLynx Application Manager.
Spectrometer as chromatographic intensity changes.
Additional Techniques Provide Enhanced Versatility
Waters: For Complete Confidence
Sales Offices:
The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometer
Waters Corporation is the world's leading provider of instruments, chemistries, software,
Austria 43 1 877 18 07
maximizes the amount of information that can be obtained across a wide range of sample types.
and support services for chromatography, mass spectrometry, thermal analysis and
Australia 61 2 9933 1777
laboratory informatics.
Belgium and Luxembourg
For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science. To learn more visit www.waters.com
32 2 726 1000 Brazil 55 11 5543 7788
GCT PREMIER MASS SPECTROMETER
Do You Need: • Wide dynamic range for characterization of complex mixtures?
Canada 800 252 4752 X2205
• Rapid spectral acquisition rates to profile narrow chromatographic peaks?
Czech Republic 420 2 617 11384
• Highly specific exact mass measurement for structural elucidation?
Denmark 45 46 59 8080
• Selectivity of high resolution to provide low determination limits?
Finland 358 9 506 4140 France 33 1 3048 7200 Germany 49 6196 400600
• High sensitivity full scan spectra to maximize sample information? • A comprehensive suite of post-processing software to maximize productivity and information output?
Hong Kong 852 29 64 1800 Hungary 36 1 350 5086 India 91 80 2837 1900 Ireland 353 1 448 1500
Take GC/MS to the Highest Level
Italy 39 02 27 4211
The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and
Japan 81 3 3471 7191
exact mass performance of the classic GCT™ with extended dynamic range. These unmatched
Figure 6. EI and CI are complementary techniques, providing
Figure 7. FI is the softest ionization technique for generating
Korea 82 2 820 2700
capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for
structural and molecular weight information.
molecular weight information on most compound types.
Mexico 52 55 5524 7636
full characterization and profiling of components in a whole range of sample types.
The Netherlands 31 76 508 7200 Norway 47 6 384 6050 People’s Republic of China 86 10 8451 8918 Poland 48 22 833 4400 Puerto Rico 787 747 8445
• Metabolomics
Russia/CIS 7 095 931 9193
• Metabonomics
Singapore 65 6278 7997
• Synthetics confirmation and QC
Spain 34 93 600 9300 Sweden 46 8 555 11 500
thermally labile compounds. The molecular ion can be seen at m/z 380.
• Natural products research
Switzerland 41 62 889 2030
• Pesticide residues monitoring
Taiwan 886 2 2543 1898
• Unknown environmental contaminants ID
UK 44 208 238 6100
• Food research and QC
US 800 252 4752
Figure 8. DCI is a softer alternative to solids probe CI for
Use the GCT Premier for Characterization and Profiling in the following Application Areas:
WATERS CORPORATION 34 Maple St. Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com
• Flavors and fragrances research and QC • Material emissions monitoring and research • Homeland security chemical monitoring • Polymer research • Petrochemicals • Materials research and monitoring
Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation. All other trademarks are property of their respective owners. ©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV
Waters Micromass GCT Premier Mass Spectrometer
Additional Techniques Provide Enhanced Versatility
Waters: For Complete Confidence
Sales Offices:
The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometer
Waters Corporation is the world's leading provider of instruments, chemistries, software,
Austria 43 1 877 18 07
maximizes the amount of information that can be obtained across a wide range of sample types.
and support services for chromatography, mass spectrometry, thermal analysis and
Australia 61 2 9933 1777
laboratory informatics.
Belgium and Luxembourg
For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science. To learn more visit www.waters.com
32 2 726 1000 Brazil 55 11 5543 7788
GCT PREMIER MASS SPECTROMETER
Do You Need: • Wide dynamic range for characterization of complex mixtures?
Canada 800 252 4752 X2205
• Rapid spectral acquisition rates to profile narrow chromatographic peaks?
Czech Republic 420 2 617 11384
• Highly specific exact mass measurement for structural elucidation?
Denmark 45 46 59 8080
• Selectivity of high resolution to provide low determination limits?
Finland 358 9 506 4140 France 33 1 3048 7200 Germany 49 6196 400600
• High sensitivity full scan spectra to maximize sample information? • A comprehensive suite of post-processing software to maximize productivity and information output?
Hong Kong 852 29 64 1800 Hungary 36 1 350 5086 India 91 80 2837 1900 Ireland 353 1 448 1500
Take GC/MS to the Highest Level
Italy 39 02 27 4211
The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and
Japan 81 3 3471 7191
exact mass performance of the classic GCT™ with extended dynamic range. These unmatched
Figure 6. EI and CI are complementary techniques, providing
Figure 7. FI is the softest ionization technique for generating
Korea 82 2 820 2700
capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for
structural and molecular weight information.
molecular weight information on most compound types.
Mexico 52 55 5524 7636
full characterization and profiling of components in a whole range of sample types.
The Netherlands 31 76 508 7200 Norway 47 6 384 6050 People’s Republic of China 86 10 8451 8918 Poland 48 22 833 4400 Puerto Rico 787 747 8445
• Metabolomics
Russia/CIS 7 095 931 9193
• Metabonomics
Singapore 65 6278 7997
• Synthetics confirmation and QC
Spain 34 93 600 9300 Sweden 46 8 555 11 500
thermally labile compounds. The molecular ion can be seen at m/z 380.
• Natural products research
Switzerland 41 62 889 2030
• Pesticide residues monitoring
Taiwan 886 2 2543 1898
• Unknown environmental contaminants ID
UK 44 208 238 6100
• Food research and QC
US 800 252 4752
Figure 8. DCI is a softer alternative to solids probe CI for
Use the GCT Premier for Characterization and Profiling in the following Application Areas:
WATERS CORPORATION 34 Maple St. Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com
• Flavors and fragrances research and QC • Material emissions monitoring and research • Homeland security chemical monitoring • Polymer research • Petrochemicals • Materials research and monitoring
Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation. All other trademarks are property of their respective owners. ©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV
Waters Micromass GCT Premier Mass Spectrometer
