Data File #F802-DST-001-Rev2

G3 Bioreactor Control Platform Flexible and reliable bioreactor control enabled by SmartPart intelligence

Scalablity

Transfer any process from 0.5L to 2000L

Modularity

Configure to control most any bioreactor size or brand

Adaptability

Plug-and-play SmartParts and 3rd party peripherals

ROI

Increase productivity and minimize down-time

Totality

Optimize globally through vessel harmonization

SmartControllers | Bioreactor Controllers

Finesse SmartControllers Universal Control

Compatible Bioreactors

Finesse has designed its third-generation

G3Lab Universal

SmartController bioreactor hardware to be highly

Glass

Total Volume (L)

configurable and easily adapted to both cell culture

Finesse SmartGlass™

1, 3, 7, 15

and fermentation applications. By leveraging

Applikon

1, 2, 3, 5, 7, 15, 20

SmartParts components, all G3 controllers have the

Sartorius STR

capability and flexibility required to optimize any process, whether in the laboratory or in a cGMPcompliant manufacturing plant. The G3 control platform incorporates innovative features that enhance the productivity, quality, and reproducibility of batch, fed batch, or perfusion processes. Upstream process scale-up strategies need not be limited to one bioreactor vendor. G3 SmartControllers have been designed to easily connect to most brands of glass, single-use, or rocker bioreactors without sacrificing the quality of control. G3 systems are modular in design, so the hardware configuration can easily evolve with

1.6, 3, 6.6, 13

®

Eppendorf (NBS)

1.3, 3, 7.5, 14

Single-Use

Total Volume (L)

Millipore Mobius CellReady™

3

Eppendorf (NBS)

1, 5, 14, 50

Xcellerex XDR

10

CerCell CellVessel

all sizes ≤ 75

Rocker

Total / Working Volume (L)

Finesse SmartRocker™

50L / 25L

GE Wave Bioreactor ®

50L / 25L

Sartorius Biostat RM

50L / 25L

™

®

G3Lite

™

Single-Use

Total Volume (L)

any process, and integrate additional functionality

Thermo Scientific HyPerforma™ SUB

All Sizes ≤ 2000

and third-party peripherals as needed.

Thermo Scientific HyPerforma SUF

All Sizes ≤ 300

Millipore Mobius CellReady™

All Sizes ≤ 200

Xcellerex XDR™

All Sizes ≤ 2000

™

G3Pro + G3Flex ™

™

Single-Use

Total Volume (L)

Thermo Scientific HyPerforma™ SUB

All Sizes ≤ 2000

Thermo Scientific HyPerforma™ SUF

All Sizes ≤ 300

Millipore Mobius CellReady

50, 200

Xcellerex XDR™

50, 200, 500, 1000, 2000

Pall PadReactor ®

25, 50, 300, 600, 1350

Sartorius STR

50, 200, 500, 1000

™

®

SmartControllers | Bioreactor Controllers

4 Modular Configurations G3Lab Universal The G3Lab Universal controls bench-top bioreactors (single-use

R&D // PD Production

or reusable up to 20L) and rockers (up to 50L). The system consists of a utility tower and a TruFlow gas manifold. G3Lab Universal controllers minimize footprint while maximizing process flexibility. By leveraging SmartParts across the range of configurations, G3Lab Universal systems enable fully traceable cGMP process scale-up or scale-down in the laboratory environment.

G3Lite G3Lite systems control single-use Thermo Scientific HyPerforma™ SUB

R&D // PD Production

(50L to 2000L) and Millipore Mobius CellReady™ (50L to 200L) bioreactors. The system consists of a control tower that leverages SmartPart transmitters, MFC’s, and pumps for superior performance. G3Lite controllers are fully self-contained, movable units that can be operated singly or networked. They are engineered to optimize capital cost without sacrificing the option of use in cGMP-certified production facilities.

G3Pro Universal The G3Pro Universal controls single-use bioreactors (25L to 2000L)

R&D // PD Production

and mixers (50L to 2000L). The system consists of a utility tower, a TruFlow gas manifold, and a Vessel Adaptor Box specific to the vessel being controlled. SmartPart transmitters and pumps are used for maximum flexibility. G3Pro controllers can be mounted on fixed skids or movable carts, can be quickly reconfigured or expanded for multiproduct applications, and have complete cGMP documentation.

G3Flex Bespoke control for any process

G3Flex systems are custom designed to run unique or highly complex processes in challenging environments (e.g., BSL-3).G3Flex systems can be fully integrated or modular. A typical system will include a utility tower, pump tower, and gas manifold, with optional accessories for perfusion, harvest, or gravimetric feeding. G3Flex systems can be used with bioreactors of any type or size in R&D, PD, pilot, and production applications.

SmartControllers | Bioreactor Controllers

SmartParts make your process excellent. SmartParts = Transmitters + Actuators

TruSens Blade Transmitter Digital signal transmission for sterilizable pH / DO and temperature sensors

TruFluor pH or DO Blade Transmitter Digital signal transmission for

SmartParts are intelligent, plug-and-play

single-use pH or DO optical sensors

hardware building blocks for measurement and control of bioprocesses. Designed for applications ranging from R&D to cGMPcompliant manufacturing processes, SmartParts are hot-pluggable, have built-in diagnostics

TruTorr Blade Transmitter Digital signal transmission for single-use pressure sensors

and factory calibrations, can be auto-detected by the network, and provide optimized local control of the given bioprocess function.

Supercharge your controller. Be SMART.

SmartScale Blade Transmitter Digital signal transmission for load cells and scales

Finesse’s third-generation SmartControllers are

SmartPumps

driven by SmartParts. These G3 systems are

Digital control of Watson Marlow®

easily configured to control any size or brand of upstream vessel. They enhance bioprocess

Series 114 / 313 / 520 / 620 pump heads

capability of each SmartPart, and increase

TruFlow Gas Manifold

productivity by decreasing the loading on

Digital control of mass flow controllers

reproducibility by exploiting the local control

the primary control and data networks.

and associated solenoids

SmartMotors Digital control of motors for bioreactor agitators and rockers

SmartControllers | Bioreactor Controllers

G3Lab Universal SPECIFICATIONS

Utility Tower Dimensions (H × W × D)

438.4 x 240 x 482.6 mm (17.3 x 9.5 x 19 in)

Enclosure Rating

NEMA2

Operating Temperature

5°C to 40°C (41°F to 104°F)

Storage Temperature

-40°C to 70°C (-40°F to 158°F)

Relative Humidity

5% to 95% Non-Condensing

Certifications

Tested and verified as meeting CE standards EN-60101 and EN 61325

Weight / Shipping Weight

14 kg / 21.4 kg (31 lbs / 47 lbs)

Agitation

Finesse SmartMotor Controller – Glass Vessel Agitator or Rocker Connection to Vessel Adapter Box – Thermo Scientific HyPerforma™ SUB Only Serial Port Connection to GE Wave™ Rocker – EHT Model Only

pH (Up to 2 Inputs)

TruSens Transmitter (Electrochemical Sensors) or TruFluor pH Transmitter (Rocker, Single-Use Vessel)

DO (Up to 2 Inputs)

TruSens Transmitter (Electrochemical Sensors) or TruFluor DO Transmitter (Rocker, Single-Use Vessel)

Temperature

TruSens Transmitter (RTD) or TruFluor (Rocker)

Foam Level

Conductivity Input

Liquid Control

Four (4) Variable-Speed Peristaltic SmartPumps, Watson-Marlow® Series 114

Cold Finger Solenoid

Digital Solenoid Valve

Gas Control (TruFlow)

Standard: Four (4) MFCs with Two (2) Output Connectors Optional: Six (6) MFCs with Three (3) Output Connectors

Scales / Load Cells

Analog Input via Scale Port

Auxiliary Connectors

Seven (7) Analog Inputs and Four (4) Analog Control Loops

Digital Input

Two (2) 24V DC

Digital Output

Two (2) Dry-Relay Contacts

Thermal Control

Heater Blanket, Chilled Water Source

External Pumps

Two (2) Watson-Marlow® Pumps on a Finesse Pump Tower

pH Cables

K8, VP, TruFluor

DO Cables

D4, VP6, VP8, TruFluor

Heater

IEC5-15 Receptacle

Vessels

Glass, 1 L to 20 L Single-Use (SUB), 2.4 L to 45 L Rocker, 10 L to 50 L

Standard Colors* (pictured below)

*Also available in clearcoated stainless as standard. Additional and custom colors are available at extra charge and longer lead times. The color examples shown are for reference only. Printed and on-screen colors may vary from actual product color.

Lime

Blueberry

Raspberry

Tangerine

Sterling Silver

SmartControllers | Bioreactor Controllers

G3Lite SPECIFICATIONS

Utility Tower Dimensions (H x W x D)

1600 x 680 x 540 mm (63 x 27 x 21 in)

Enclosure Rating

NEMA12 / IP52

Operating Temperature

5ºC to 40°C (41ºF to 104°F)

Storage Temperature

-25ºC to 70°C (-15ºF to 158°F)

Relative Humidity

5% to 95% Non-Condensing

Certifications

Manufactured to conform to CE specifications EN-60101 and EN-61325

Weight / Shipping Weight

68 kg / 136.1 kg (150 lbs / 300 lbs)

Agitation

Thermo Scientific HyPerforma™ SUBs: 1/4HP or 1/2HP AC 3-Phase Induction Motor

pH (Up to 2 Inputs)

TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)

DO (Up to 2 Inputs)

TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)

Temperature

TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)

Pressure

TruTorr Transmitter (Single-Use)

Liquid control

Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520

Gas Control (TruFlow)

Basic: Four (4) MFCs with Two (2) Output Connectors Recommended: Six (6) MFCs with Three (3) Output Connectors

Scales / Load Cells

SmartScale Transmitter

Auxiliary

Two (2) Analog Inputs (12-bit, 4 to 20 mA); Two (2) Auxiliary Control Loops (4 to 20 mA)

Digital Output

Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact

Thermal Control

Heater Blanket or Analog Temperature Control Unit (TCU)

Vent Filter Heaters

Two (2) Heaters for Pall KA3™ or Meissner UltraCap® 10-inch Filters

External Pumps

Up to two (2) Additional External SmartPumps, Watson Marlow® Series 114, 313, 520, 620 Freestanding or on a Finesse SmartPump Tower

pH Cables

K8, VP, TruFluor

DO Cables

D4, VP6, VP8, TruFluor

Vent Filter Heater Connection

IEC 60309 6H Receptacle 2P+E or External Heater Power Box for Larger Jacketed SUBs

SUBs (Single-Use Vessels)

50 L to 2000 L

HMI

Standard Flatscreen Color Monitor, Washable Keyboard and Mouse

SmartControllers | Bioreactor Controllers

G3Pro Universal SPECIFICATIONS

Utility Tower Dimensions (H x W x D)

914.4 x 609.6 x 228.6 mm (36 x 24 x 9 in)

Cart Dimensions (H x W x D) Stand Alone Mounting Cart with Wheels

178 x 71 x 81 cm (70 x 28 x 32 in)

Enclosure Rating

NEMA 12/IP54 or optionally NEMA 4X/IP65

Operating Temperature

5°C to 40°C (41ºF to 104°F)

Storage Temperature

-25°C to 85ºC (-13ºF to 185ºF)

Relative Humidity

5% to 95% Non-Condensing

Certifications

Tested and Verified as Meeting CE Standards EN-60101 and EN 61325

Weight / Shipping weight

18.1 kg / 41 kg (40 lbs / 90 lbs)

Cart Weight*

75 kg (165 lbs)

Agitation

Depends on Vessel Manufacturer, Control Through VAB (Vessel Adaptor Box)

pH (Up to 3 Inputs)

TruSens Transmitter (Electrochemical), TruFluor pH Transmitter (Single-Use)

DO (Up to 3 Inputs)

TruSens Transmitter (Electrochemical), TruFluor DO Transmitter (Single-Use)

Temperature

TruSens Transmitter (RTD) and/or TruFluor pH/DO Transmitters (Single-Use)

Pressure

TruTorr Transmitter (Single-Use)

Liquid control

Four (4) variable-speed peristaltic SmartPumps, Watson Marlow® Series 114, 313, or 520

Gas Control (TruFlow)

Standard: Six (6) MFCs with Three (3) Output Connectors Optional: Four (4) MFCs with Two (2) Output Conntectors

Scales / Load Cells

Analog Input on Vessel Adapter Box

Auxiliary

Eight (8) Analog Inputs and Four (4) Analog Control Loops

Digital Output

Two (2) 24V Outputs; One (1) Dry Relay Alarm Contact

Thermal Control

Heater Blanket or Chilled Water Source (up to 250 L Vessel) Thermal Control Unit (TCU) for Jacketed Vessels

Vent Filter Heaters

MKS Cable Compatible with Pall or Meissner Vent Filter Heaters

External Pumps

Watson Marlow (Series 100, 300, 500 or 600) in Standalone SmartPump or SmartPump Tower

pH Cables

K8, VP, TruFluor

DO Cables

D4, VP6, VP8, TruFluor

Heater Connection

Cable Specific to Heater Connected at VAB (Vessel Adapter Box)

SUBs (Single-Use Vessels)

50 L to 2000 L

Vessel Adapter Box (VAB)

Thermo Scientific HyPerforma™ SUB: 50, 100, 250, 500, 1000, 2000 L GE / Xcellerex XDR: 50, 200, 500, 1000, 2000 L ATMI PadReactor: 25, 50, 600, 1350 L Millipore Mobius CellReady: 50, 200 L Sartorius STR: 50, 200, 500, 1000 L ASI™ 50, 300 L

Third Party Sensors (Analog Output)

CO2 – Mettler Toledo®; Cell Density – Endress+Hauser; Cell Viability – Aber™ / Fogale; Pressure / Flow

HMI

19 in Color Touch Screen Industrial LCD, NEMA 4X, 1280 x 1024, 24-Bit Color, Keyboard and Mouse

*Note that the controller is not designed to be free-standing. For this reason the controller is only shipped with the cart, for a combined weight of 116 kg (256 lbs)

SmartControllers | Bioreactor Controllers

G3Flex The Finesse G3Flex is a custom bioprocess controller based on SmartParts and designed to fill a specific application requirement. For more information about the Finesse G3Flex, please contact your local Finesse representative.

TruFlow Gas Manifold GENERAL SPECIFICATIONS* Operating Temp

5ºC to 40ºC (41ºF to 104ºF)

Storage Temp

-25ºC to 70ºC (-15ºF to 158ºF)

Relative Humidity

5% to 95% (Non-Condensing)

Certification

CE (EN-61326 and EN-61010)

Inlet Pressure

0.7 to 2.75 bar / 10 to 40 psig

Outlet Pressure

0 to 1.38 bar / 0 to 20** psig

Accuracy

±0.8% of Rate ±0.3% Full Scale (Burkert)

Repeatability

±0.1% Full Scale (Burkert)

PHYSICAL DESCRIPTION

4x2 GAS MANIFOLD

6x3 GAS MANIFOLD

Dimensions (H x W x D)

190.5 x 177 x 184.2 mm (7.5 x 7.0 x 7.25 in)

190.5 x 267 x 184.2 mm (7.5 x 10.5 x 7.25 in)

Rating

NEMA 2 / IP11

NEMA 2 or NEMA 4X (Optional)

Weight / Shipping Weight

4.5 kg / 6.8 kg (10 lbs / 15 lbs)

7.3 kg / 9.1 kg (16.2 lbs / 20 lbs)

Mass Flow Controllers

Up to Four (4) Per Vessel for G3Lab

Up To Six (6) Per Vessel (Standard)

Solenoid Valves

Two (2) Per Gas

Three (3) Per Gas

Headers / Spargers

Two (2) Total Per Manifold

Three (3) Total Per Manifold

COMPONENTS

* Subject to change without notice. **Minimum pressure differential depends on flow rate 30 slpm requires 20 psi differential, 1 slpm or less requires 10 psi.

Finesse Solutions, Inc. Global Headquarters USA 3501 Leonard Court Santa Clara, CA 95054 USA Toll free +1 800 598 9515 Tel +1 408 570 9000 Fax +1 888 235 6086 [email protected] Boston USA 5 Perry Way Newburyport, MA 01950 USA +1 978 255 1296 United Kingdom 4 Grove Court, Leicester LE19 1SA, UK +44 116 289 7149 Europe Via Sogn Gieri 27a CH-7402 Bonaduz, Switzerland +41 81 641 2000 Benelux, Ireland & Scandinavia Van Slingelandtlaan 13 3332 JJ Zwijndrecht The Netherlands +31 6 836 00 180 Asia-Pacific Unit 2317, No. 150 HuBin Road No. 5 Corporate Avenue Center HuangpPu District Shanghai 200023, China +86 21 8013 5067 [email protected]

www.Finesse.com

31 Rochester Drive Penthouse Levels 24-17 Singapore 138637 +65 6808 8724 [email protected]

Every effort has been made to ensure the accuracy of the information in this document. However, Finesse reserves the right to change its products without notice. The following are Finesse Solutions, Inc. registered trademarks: TruViu, TruBio, TruBio DV, TruBio µC, SmartOPC, TruService, TruTorr, TruFluor, TruLogic, TruConnect, TruMigrations, TruCables, TruHousings, SmartGlass, SmartSoftware, SmartRocker, TruDO, TrupH, SmartFactory, SmartChip, SmartSystems, SmartBag, SmartPuck, SmartReader, SmartBag Reader, SmartTray, SmartController, SmartSensor. © 2015-2016, Finesse Solutions, Inc. All other trademarks are the property of their respective owners.