Swiss Society for Allergology and Immunology – SSAI-SGAI

Annual Congress in parallel with the World Immune Regulation Meeting 20–21 March 2014, Davos, GR Final Program

From Anaphylaxis to Vasculitis

XOLAIR® DAS EXAZERBATIONSRISIKO UNTER KONTROLLE BEI SCHWEREM ALLERGISCHEM ASTHMA1,2*

Für den Grossteil Ihrer XOLAIR®-Patienten

JETZT NEU NUR NOCH 1 x STATT 2 x MONATLICH3

XOLAIR® (Omalizumab). Z: Omalizumab; Stechampulle mit Pulver à 150 mg Omalizumab und Lösungsmittel zur Herstellung einer Injektionslösung. I: In Kombination mit anderen Asthmatherapien zur verbesserten Asthmakontrolle bei Erwachsenen und Kindern (ab 6 Jahren) mit schwerem persistierendem allergischem Asthma (positiver Hauttest oder in vitro-Reaktivität gegen ein ganzjährig auftretendes Aeroallergen), falls diese trotz täglicher Therapie mit hoch dosierten inhalativen Kortikosteroiden und einem langwirksamen Beta2-Agonisten sowohl eine reduzierte Lungenfunktion (FEV1 < 80 %) haben als auch unter häufigen Symptomen während des Tages oder nächtlichem Erwachen leiden und Asthmaexazerbationen hatten. D: Erwachsene und Kinder ab 6 Jahren: 75 - 600 mg XOLAIR® 1 - 2x/Monat basierend auf dem IgE-Basis-Wert (I.E./ml) im Serum und des Körpergewichts des Patienten. Einzelheiten s. www.swissmedicinfo.ch. KI: Überempfindlichkeit gegenüber dem Wirkstoff oder einem der Inhaltsstoffe. VM: Nicht indiziert zur Behandlung von akuten Asthmaexazerbationen, akuten Bronchospasmen und Status asthmaticus. Nicht untersucht bei Hyper-Immunglobulin-E-Syndrom, allergischer bronchopulmonaler Aspergillose, Prävention allergischer Reaktionen, atopischer Dermatitis, allergischer Rhinitis, Lebensmittelallergien, Autoimmunerkrankungen, Immunkomplex-vermittelten Zuständen, bestehender Nieren- oder Leberfunktionsstörung. Reduktion von Kortikosteroiden unter ärztlicher Aufsicht. Allergische Reaktionen oder lebensbedrohliche Anaphylaxie und anaphylaktischer Schock können auftreten. Serumkrankheit und ähnliche Symptome wurden selten beobachtet. Selten Churg-Strauss-Syndrom und hypereosinophiles Syndrom. Probleme im Zusammenhang mit Immunogenität, parasitären (Wurm-) Infektionen oder Malignitäten können auftreten. Einzelheiten s. www.swissmedicinfo.ch. IA: Es gibt keine Hinweise auf veränderte Sicherheit durch andere i.a. eingesetzten Asthmamedikamente. Die Wirksamkeit der Behandlung in Kombination mit spezifischer Immuntherapie wurde nicht nachgewiesen. UW: Sehr häufig: Pyrexie. Häufig: Schmerzen im oberen Unterleib, Kopfschmerzen, Schmerzen, Erythem, Pruritus, Schwellung. Gelegentlich: Pharyngitis, Schwindel, Schläfrigkeit, Parästhesie, Synkope, orthostatische Hypotonie, Flush, Husten, allergische Bronchospasmen, Nausea, Diarrhoe, Dyspepsie, Urtikaria, Rash, Pruritus, Photosensibilität, Gewichtszunahme, Müdigkeit, Anschwellen der Arme, grippeähnliche Symptome. Selten und sehr selten s. www.swissmedicinfo.ch. Postmarketing: Anaphylaxie und anaphylaktoide Reaktionen, Alopezie, idiopathische schwere Thrombozytopenie, allergische granulomatöse Angiitis (d.h. Churg-Strauss-Syndrom), Arthralgie, Myalgie, Gelenkschwellung. Malignitäten, Thrombozyten, Labordaten, Parasitäre Infektionen: s. www.swissmedicinfo.ch. P: 1 Stechampulle zu 150 mg mit 1 Lösungsmittelampulle zu 2 ml. Verkaufskategorie: B. Kassenzulässig. Weitere Informationen finden Sie unter www.swissmedicinfo.ch. ZUL: Novartis Pharma Schweiz AG, Risch; Adresse: Suurstoffi 14, 6343 Rotkreuz, Tel. 041 763 71 11 V6

26433/02-14

*bezogen auf die Anzahl Asthmaexazerbationen. 81.9 %, resp. 95.6 % der XOLAIR® Responder (gemäss GETE - Global Evaluation of Treatment Effectiveness) hatten über einen Zeitraum von 24 Monaten keine klinisch signifikanten resp. keine schweren klinisch signifikanten Asthmaexazerbationen.2 1 Humbert M, Beasley R, Ayres J, et al.: Benefits of omalizumab as addon therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy, 2005 Mar;60(3):309-16. 2 Braunstahl GJ et al: The eXpeRience registry: The ‘real-world’ effectiveness of omalizumab in allergic asthma. Respiratory Medicine. 2013;107,1141-1151. 3 Fachinformation XOALIR® www.swissmedicinfo.ch.

Novartis Pharma Schweiz AG Postfach, 6343 Rotkreuz. www.novartispharma.ch

Contents Welcome to Davos Prof Dr Peter Schmid-Grendelmeier, Chair SSAI Congress

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Dr Federica Sallusto, President SSAI

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Prof Dr Cezmi Akdis, Chair WIRM

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Organization

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Program at a glance – Thursday, March 20, 2014

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Lunch Symposium 1 – March 20, 2014

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Program – Thursday, March 20, 2014

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Program at a glance – Friday, March 21, 2014

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Lunch Symposium 2 – March 21, 2014

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Program – Friday, March 21, 2014

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Program WIRM VIII – March 19–22, 2014

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ACTERIA Fondation

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Chairpersons and speakers

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Sponsors

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Exhibitors

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Map Congress Centre Davos

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Meeting Information

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Notices

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Welcome to Davos Dear Colleagues, It is my great pleasure to welcome you on behalf of the ­organizing committee to the 2014 SSAI meeting in Davos. Davos is a city that has always been linked to Allergy as well as to the University of Zurich. Thus, the Zurich team has decided to come to this beautiful place and organize a meeting which hopefully fulfills all your expectations in scientific and social aspects. Sharing the meeting with the world-renowned WIRM, the World Immune Regulation Meeting, chaired by Prof. Cezmi Akdis and his collaborators at the Swiss Institute of Allergy and Asthma Research (SIAF), offers an excellent forum for exchange for our researchers interested in basic immunology. On the other hand, the clinical track reflects the broadness of our speciality, from anaphylactic reactions to vasculitic disorders, from laboratory ana­lyses to practical skills. Plenary sessions, several workshops and focused symposia will offer a broad spectrum of educational activities for researchers, clinicians and, new this year, allied health personnel. We are also very happy that many international and national experts have agreed to share their experience and insights with you to make this meeting a very successful one. I would like to thank the entire teams of Zurich and Davos for allowing us to ­realize this joint approach between SSAI and WIRM, all our sponsors that ge­nerously support us in realizing such an event and last, but not least, Mrs. Evelyne Schenk, SSAI head assistant, and Mrs. Sandra Crameri from SIAF for their excellent and dedicated support. Besides the scientific aspects, such a meeting is also an excellent place to meet friends and make new ones. We hope that you will have many chances for such encounters and will spend a fruitful and very rewarding time in the splendid ­scenery of Davos. Have an excellent meeting! On behalf of the whole Local Organizing Committee,

Prof. Peter Schmid-Grendelmeier, MD Congress Chair

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Welcome to Davos Dear Colleagues and Friends, I am delighted to welcome you to the Annual Congress of the Swiss Society for Allergology and Immunology. The SSAI Annual Congress is the most important gathering of the Swiss allergology and immunology community and has always been an outstanding international meeting. This is even more true this year thanks to the partnership with the World Immune Regulation Meeting. Together, SSAI-2014 and WIRM-VIII offer an outstanding program, with highlights in fundamental aspects of immunology and allergology, a showcase of progresses in clinical and translational aspects, and a strong emphasis on education. I cordially invite all the members of the SSAI to attend the General Assembly which will take place on Thursday from 17:30 until 19:00. This session will include the annual reports to SSAI members on the activities of the different commissions and will feature the 2014 Honorary Membership award ceremony. I also invite all ­participants to join us for the Gala dinner at the stunning Schatzalp Snow & Mountain Resort, a historic hotel built in art-nouveau style and one of Switzerland‘s most spectacularly situated hideaway hotels. To reach the restaurant, we will take a short ride on the hotel’s private funicular from the center of Davos Platz. On this occasion, I would like to express my special gratitude to Peter SchmidGrendelmeier and the members of the Organizing committee for their efforts in setting up an excellent scientific program and a special social event. On behalf of the SSAI, I also would like to express our gratitude to corporate and public ­sponsors of the congress. Without their commitment and support, we would not have been able to set-up a meeting with such a high scientific standard. SSAI 2014 will give us the chance to meet colleagues, reunite with friends, make new acquaintances and enjoy the spectacular beauty of Davos. In keeping with the spirit of SSAI, I hope that the interactions and collaborations that take place at this meeting will bear fruit in future advances in biomedical research. I thank everyone for participating and wish you all a pleasant stay,

Dr. Federica Sallusto SSAI President

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Welcome to Davos Dear Friends and Colleagues, On behalf of the Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich and Davos Allergy Im­ munology Community, it is my great pleasure to welcome you to Davos for the Annual Congress of the Swiss Society for Allergology and Immunology (SSAI). This year the main SSAI meeting, will meet with the 8th World Immune Regulation Meeting (WIRM). We have outstanding programmes in both meetings with more basic immunology focus in WIRM and clinical im­munology focus in the SSAI. Participants of WIRM and SSAI will have free access to the sessions and booth area of both meetings. I would like to thank Dr. Federica Sallusto, President SSAI, Prof. Peter Schmid-Grendelmeier, SSAI ­Congress Chair, Mrs. Evelyne Schenk, SSAI head assistant, and Mrs. ­Sandra Crameri, SIAF Head of Communications and Congresses for their outstanding work and commitment for the success of both meetings. These two meetings will bring Swiss science to meet international science in the most inspiring atmosphere of Davos. Here, I would like to remind you that the inspiration of Davos has been much earlier confirmed by Erich von Däniken, who wrote «Chariots of the Gods» when he was the manager of Hotel Rosenhügel. In addition, Thomas Mann wrote «Magic Mountain», Robert Louis Stevenson wrote Treasure Island and Sir Arthur Conan Doyle wrote some of the Sherlock Holmes stories in Davos. If you want to have a tour around Davos, I particularly suggest the hiking route „Hohe Promenade“ or a sightseeing around the Davos lake. Do not forget to take nuts or dry fruits with you to feed the squirrels. Davos squirrels are used to eating from your hands and with a little bit of sunshine, they will wake up and will be waiting for you on these routes. Have great congresses

Prof. Cezmi Akdis Director SIAF Chair WIRM

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Organization Congress Chair Peter Schmid-Grendelmeier, University Hospital, Zurich Email: [email protected] Co-Chairs Barbara Ballmer-Weber , University Hospital Zurich Onur Boyman, University Hospital Zurich Annette Oxenius, ETH Zurich President of the Swiss Society for Allergology and Immunology SSAI Federica Sallusto, IRB, Università della Svizzera Italiana, Bellinzona Email: [email protected] Members of the Local Organizing and Scientific Committee Burkhard Becher, Sandra Beeler-Trüssel, Ch. Clarenbach, Oliver Dist­ ler, Dominik Harder, Thomas Hauser, Alice Köhli-Wiesner, Manfred Kopf, Thomas Kündig, Günter Menz¸ Christian Münz, Jana Pachlopnik, Ulf Petrausch, Stephan Regenass, Jeannine Reichenbach, Michael Soyka, Maries van den Broek, Christina Weber, Myriam Wyss Fopp, Annelies Zinkernagel Administrative Congress Organization Evelyne Schenk, SSAI, Scheibenstrasse 20, CH-3000 Bern 22 Tel: +41 31 359 90 91, Fax: +41 31 359 90 92 Email: [email protected] WIRM, Davos, Sandra Crameri Tel : +41 81 410 08 42, Fax : +41 81 410 08 40 Email : [email protected] Congress Centre Davos, Hilda Leitner Tel: +41 81 415 21 65, Fax: +41 81 415 21 69 Email: [email protected]

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faster and more effective in seasonal allergic rhinitis

1

NEW 1. Compared vs. intranasal fluticasone propionate and azelastine hydrochloride. Meltzer E et al. Clinically Relevant Effect of a New Intranasal Therapy (MP29-02) in Allergic Rhinitis Assessed by Responder Analysis. Int Arch Allergy Immunol 2013; 161(4):369-377. Dymista® Nasenspray (Azelastinhydrochlorid/Fluticasonpropionat): Antihistaminikum/Corticosteroid. Indikationen: Saisonale allergische Rhinitis und Rhinokonjunktivitis. Dosierung: Ab 12 Jahren: 1 Sprühstoss (0,14 mg Azelastinhydrochlorid/0,05 mg Fluticasonpropionat) pro Nasenloch 2x täglich. Kontraindikationen: Überempfindlichkeit gegen Inhaltsstoffe. Warnhinweise und Vorsichtsmassnahmen: Nasale Corticosteroide in hohen Dosen über einen längeren Zeitraum verwendet, können systemische Effekte haben wie z.B. Cushing-Syndrom, Wachstumsverzögerung, Katarakt oder Glaukom. Schwangerschaft: nur wenn klar notwendig. Stillzeit: nicht empfohlen. Interaktionen: Hoch potente Inhibitoren des Cytochrom-P450 3A4-Systems wie z.B. Ritonavir. Unerwünschte Wirkungen: Kopfschmerzen, Dysgeusie. Epistaxis, nasale Beschwerden (Stechen, Juckreiz), Niesen, Nasentrockenheit, Husten, Halstrockenheit, Halsreizung. (UW < 0,1% siehe AIPS). Packungen: Nasenspray 17 ml. (B). Kassenzulässig. Ausführliche Informationen: Packungsbeilage, AIPS (www.swissmedicinfo.ch) oder MEDA Pharma GmbH, 8602 Wangen-Brüttisellen. Stand der Information: Januar 2013.

SSAI program at a glance Thursday, March 20, 2014

Room Sanada

Room Seehorn

Room Wisshorn

10.15 – 11.15

Workshop I Nasal challenge tests

Workshop II Lung function for allergists

11.15 – 11.30 Opening address



11.30 – 13.05 Symposium I Oral Life-threatening communications: allergic reactions Basic immunology – mechanism 13.10 – 14.10 Lunch break

Lunch Symposium 1 Diagnostic and therapeutic dilemma – From nose to skin (sponsored by MEDA Pharma GmbH)

14.15 – 15.45 Symposium II Immunodeficiencies

Clinical Laboratory session: Laboratory aspects of clinical immunology and allergy

15.45 – 16.15 Coffee break 16.15 – 17.15 Symposium III From skin to lung

Poster discussion session: Laboratory and clinical aspects

Symposium Aerobiology/SGA

17.30 – 19.00 General Assembly SSAI 20.00

SOCIAL EVENT Gala Dinner at Schatzalp



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Lunch Symposium 1

Diagnostic and therapeutic dilemmas – From nose to skin Thursday, March 20, 2014, 13.10 – 14.10 Room Sanada

Chairman:

Peter Schmid-Grendelmeier (Zurich)

Introduction Peter Schmid-Grendelmeier Leiter der Allergiestation Dermatologische Klinik Universitätsspital Zurich Nasal congestion: simply rhinitis or more? Michael B. Soyka Oberarzt Rhinologie Klinik für Ohren-, Nasen-, Hals- und Gesichtschirurgie Universitätsspital Zurich Management of atopic eczema in childhood Lisa Weibel Leitende Ärztin Abteilung Pädiatrische Dermatologie Universitäts-Kinderspital Zurich Q&A (10 min)

Program Thursday, March 20, 2014 10.15 – 11.15 Workshop I _________________________________ Room Seehorn Nasal challenge tests Dominik Harder (Chur), Michael Soyka (Zurich)

Workshop II _______________________________ Room Wisshorn Lung function for allergists Christian Clarenbach (Zurich), Julia Genser (Zurich), Thomas Rothe (Davos)

11.15 – 11.30

Opening address _ ___________________________ Room Sanada Federica Sallusto (Lugano), President SSAI Cezmi Akdis (Davos), Congress Chair WIRM Peter Schmid-Grendelmeier (Zurich), Congress Chair SSAI

11.30 – 13.05 Symposium I _ _______________________________ Room Sanada Life-threatening allergic rections Chairs: Alice Köhli-Wiesner (Zurich), Thomas Harr (Geneva) 11.30 – 12.00 New insights into anaphylaxis Estelle Simons (Canada) 12.00 – 12.30 Anaphylaxis in childhood Philippe Eigenmann (Geneva) 12.30 – 13.00 Severe cutaneous drug reactions Lars French (Zurich) 13.00 – 13.05 National Allergy Day 2014 Georg Schäppi (Bern)

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11.30 – 13.00 Oral communications _______________________ Room Seehorn Basic immunology - mechanism Chairs: Manfred Kopf (Zurich), Burkhard Ludewig (St. Gallen)

15 min Presentation plus 5 min Discussion /Abstract

11.30

OP 1 Epithelial-cell conditioned media strongly increases expression of BDCA-3 on monocytes which is markedly involved in the release of IL-10 Valérie Cesson, Laurent P. Nicod and Carolina Obregon Pneumology Service, CHUV, Lausanne, Switzerland

11.50

OP 2 A novel role of the nuclear receptor LRH-1/NR5a2 in T cell development and regulation Carina Seitz1, Juliane Schwaderer1, Ann-Kathrin Fuchs1, Pamela Bianchi2, Kristina Schoonjans3 and Thomas Brunner1 1 Biochemical Pharmacology, University of Konstanz, Germany 2 Institute of Pathology, University of Bern, Switzerland 3 Laboratory of Integrative Systems and Physiology, EPFL, Switzerland

12.10

OP 3 High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis Brembilla N. C.1,2,3, Lonati P.1,4, Fontao L.2, Laffitte E.2, Kaya G.2, Meroni PL.4,5,6, Chizzolini C.1,3 1 Immunology & Allergy and 2 Dermatology, University Hospitals of Geneva, Geneva, Switzerland, 3 Department of Pathology and Immunology, School of Medicine, University of Geneva, Geneva, Switzerland, 4 IRCCS Istituto Auxologico Italiano, Milan, Italy; 5 Division of Rheumatology, Ist. G Pini, Milan, Italy, 6 Department of Clinical and Community Sciences, University of Milan, Italy.

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12.30



OP 4 The absence of TNF exacerbates spontaneous neuroinflammation in MOG-specific TCR-transgenic (2D2) mice Nora Schweizer1, Cinzia Tiberi2, Elisabeth Rushing2, Hans Welzl3, Mirjana Wojtal1, and Tobias Suter1 1 Clinics for Immunology and Section of Neuroimmunology and MS Research, University Hospital, Zürich 2 Neuropathology, University Hospital, Zürich 3 Institute of Anatomy, University of Zürich, Zürich

13.10 – 14.10

Lunch Symposium 1 _________________________ Room Sanada Diagnostic and therapeutic dilemmas – From nose to skin Sponsored by MEDA Pharma GmbH Chair: Peter Schmid-Grendelmeier (Zurich)



Nasal congestion: simply rhinitis or more? Michael Soyka (Zurich)



Management of atopic eczema in childhood Lisa Weibel (Zurich)

14.15 – 15.45 Symposium II ______________________________ Room Sanada Immunodeficiencies Chairs: Jana Pachlopnik (Basel), Werner Joseph Pichler (Bern) 14.15 – 14.45 New defects of innate immunity Anne Puel (France) 14.45 – 15.15 Human dendritic cells in health and disease Muzlifah Haniffa (United Kingdom) 15.15 – 15.45 Gene therapy of immune defects Janine Reichenbach (Zurich)

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14.15 – 15.45 Clinical Laboratory session __________________ Room Seehorn Laboratory aspects of clinical immunology and allergy Chairs: Ingmar Heijnen (Basel), Stephan Regenass (Zurich) 14.15 – 14.45 In vitro diagnosis of food allergy Lars Poulsen (Denmark) 14.45 – 15.15 Cryoglobulin evaluation: the best practice? Ravishankar Sargur (United Kingdom) 15.15 – 15.45 Diagnosis of primary antibody deficiency Mirjam van der Burg (Netherlands) 15.45 – 16.15 Coffee break 16.15 – 17.15 Symposium III _______________________________ Room Sanada From skin to lung Chairs: François Spertini (Lausanne), Carlo Chizzolini (Geneva) 16.15 – 16.45 Challenges of translational science in scleroderma Oliver Distler (Zurich) 16.45 – 17.15 Skin inflammation and asthma: close and far Stefanie Eyerich (Germany) ACTERIA Price Winner 2013 16.15 – 17.15 Poster discussion session_____________________ Room Seehorn Laboratory and clinical aspects Chairs: Mark Anliker (St. Gallen), Vincent Aubert (Lausanne)

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P 1 The spectrum of disease manifestation in adult patients with PID Peter Jandus1, Michaela Bitzenhofer-Grüber2, Werner Joseph Pichler2, Arthur Helbling2,3 1 Allergy and Clinical Immunology Unit, University Hospital Geneva, Switzerland 2 Department of Rheumatology, Clinical Immunology and Allergology, Allergy Unit, Inselspital, Bern, Switzerland



Allergy Unit Zieglerspital, Internal Medicine, Spital Netz Bern, Switzerland



P 2 Perioperative allergic reaction after physiogel – and related gelatine/beef allergy due to sensitization to alphagalactose-1,3-galactose (alpha-Gal) Nadia Galliker1, Florence Vallelian2, Ulf Petrausch3, Barbara Ballmer - Weber1, Peter Schmid - Grendelmeier1 1 Allergy Unit, Dept. of Dermatology, 2 Dept. of Internal Medicine and 3 Dept. of Oncology, University Hospital of Zurich, Switzerland



P 3 Near fatal anaphylaxis after bee sting in mastocytosis patient under ongoing SIT: due to molecular mismatch of honey bee allergens (api m10, api m 3) between SIT extract and crude honey bee venom? Sandra Micaletto1, Kurt Roetzler2, Markus Ollert3, Edzard Spillner4, Wolfram Hoetzenecker1, Martin Bruesch2, Peter Schmid-Grendelmeier1 1 Allergy Unit, Dept. of Dermatology, Zurich, Switzerland; 2 Institute for Anesthesiology, University Hospital, Zurich, Switzerland; 3 TU München, Dept. of Dermatology, Munich, Germany 4 Institute of Biochemistry and Molecular Biology, Hamburg, Germany



P 4 Treatment of severe cold contact urticaria with omalizumab: case reports Julia K. Genser1, Petra Brodskà1,2, Peter Schmid-Grendelmeier1 1 Allergy Unit, Dept. of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland 2 Department of Dermatology and Venereology, Medical Faculty and Teaching Hospital, Charles University, Pilsen, Czech Republic



3

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P 5 Serum IgE levels and micro-array based sensitization patterns in Amaxhosa atopic dermatitis patients in Cape Town Region, South Africa Fatema Thawer-Esmail1, Alan Irvine2, Henri Carrara3, Gail Todd1, Peter Schmid-Grendelmeier4 1 Division of Dermatology, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa, 2 Our Lady‘s Hospital for Sick Children, Dublin, Ireland, 3 School of Public Health and Family Medicine, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa, 4 Allergy Unit, Dept of Dermatology, University Hospital of Zurich, Switzerland



P 6 Allergy of the delayed type to corticosteroids from various subgroups – two similar cases Judith A. Schneider Spence1, Andreas J. Bircher1 1 Allergy Unit, Department of Dermatology, University Hospital Basel, Switzerland

16.15 – 17.15 Symposium Aerobiology/SGA _______________ Room Wisshorn Chair: Oliver Hausmann (Bern/Lucern) 16.15 – 16.40 16.40 – 17.05 17.05 – 17.15 16

Stadtbäume als Allergenquellen: Kriterien und Bepflanzungsalternativen Axel Fischer, Geschäftsleitung Grün Stadt Zurich/ Leiter Geschäftsbereich Unterhalt, Zurich Pollenprognose: Modellierung, Interpretation und praktische Anwendung Andreas Pauling, Biometeorologe MeteoSchweiz, Zurich e-symptoms: elektronisches Symptomtagebuch in der Praxis Sereina Maibach, Projektleitung und Beratung, Fachdienstleistungen aha! Allergiezentrum Schweiz, Bern

17.30 – 19.00 General Assembly SSAI ______________________ Room Sanada 20.00

SOCIAL EVENT Gala Dinner at Schatzalp



The Gala dinner at Schatzalp starts at 8pm. We welcome you warmly for this evening in the beautiful setting of the Schatzalp. This tratitional hotel is reached by a short ride on the Schatzalp funicular from the main street and enjoys glorious panoramic views across the valley. Plesant music and an excellent cuisine will contribute to a hopefully unique and wonderful evening with friends and colleagues in a peaceful location 300 meters above Davos.



Directions Schatzalp is car-free. From the center of Davos Platz, you can reach it with the local cable car in 4 minutes. The time schedule will be adapted accordingly. Your registration for the Gala Dinner includes the ride with the cable that is offered by SSAI. With your congress badge a voucher for the Gala Dinner is handed out.

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SSAI program at a glance Friday, March 21, 2014

Room Seehorn

Room Wisshorn

08.00 – 09.00 Workshop III HAE: Practical approach

Workshop IV Drug hypersensitivity: Work up, Desensitization

09.15 – 10.45 Symposium IV CDR in daily clinical practice

Oral communications: Experimental allergy and immunology

Oral communications: Clincal allergy and aerobiology

10.45 – 11.15 Coffee break



11.15 – 12.45 Symposium V Infection and Allergy

Forum der Praktiker: Allergy prevention in childhood – has everything changed now? Anaphylaxis education – new concepts

12.55 – 13.55 Lunch break

Room Sanada

Lunch Symposium 2 What‘s new for Omalizumab? Current and future developments (sponsored by Novartis Pharma Schweiz AG)

14.00 – 15.30 Symposium VI Vasculitis: from pathomechanism to therapy 15.30 – 16.00 Coffee break 18

Oral communications: Investigational allergy and immunology

Allergie-Symposium für Pflegende und MPA Teil I (14.15 – 15.30)

16.00 – 16.15 Award ceremony

Allergie-Symposium für Pflegende und MPA Teil II (16.00 – 16.45)

16.15 – 17.45 Symposium VII Treatment: what is new? 17.45 – 18.00 Closure of the meeting

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Lunch Symposium 2

What’s new for Omalizumab? Current and future developments Friday, March 21, 2014, 12.55 – 13.55 Room Sanada

Chairman:

Prof. Dr. med. Peter Schmid-Grendelmeier (Zurich)

Introduction Prof. Dr. med. Peter Schmid-Grendelmeier Experiences with Omalizumab: New Real-Life Data Prof. Dr. med. Jörg Leuppi Chefarzt Medizinische Universitätsklinik Professor für Innere Medizin Universität Basel Kantonsspital Baselland Diagnosis and Management of Chronic Spontaneous Urticaria Prof. Dr. med. Peter Schmid-Grendelmeier Leiter der Allergiestation Dermatologische Klinik Universitätsspital Zurich Clinical development of Omalizumab in Chronic Spontanous Urticaria Dr. med. Oliver Hausmann Oberarzt I Allergologisch-immunologische Poliklinik Universitätsklinik für Rheumatologie klinische Immunologie und Allergologie Inselspital Bern Q&A (10 min)

Program Friday, March 21, 2014 08.00 – 09.00 Workshop III _______________________________ Room Seehorn HAE: Practical approach Urs Steiner (Bern), Christina Weber (Zurich)

Workshop IV _ _____________________________ Room Wisshorn Drug hypersensitivity: Work up, Desensitization Ulf Petrausch (Zurich), Wolfram Hötzenecker (Zurich)

09.15 – 10.45 Symposium IV _______________________________ Room Sanada CRD in daily clinical practice Chairs: Barbara Ballmer-Weber (Zurich), Ingmar Heijnen (Basel) 09.15 – 09.45 Molecular allergens: where are we? Ronald van Ree (Netherlands) 09.45 – 10.15 Inhalant mammal allergens Jonas Lidholm (Sweden) 10.15 – 10.45 Hymenoptera Markus Ollert (Germany) 09.15 – 10.45 Oral communications _______________________ Room Seehorn Experimental allergy and immunology Chairs: Christoph Müller (Bern), Daniel Speiser (Lausanne)

15 min Presentation plus 5 min Discussion /Abstract

09.15 – 09.35

OP 5 Investigation of the pathogenesis of chronic spontaneous urticaria (CU) by analyzing the different activation pathways of donor basophils stimulated with the serum of CU patients in vitro Carolina Diaz1,2, Tatjana Pecaric Petkovic1,2, Antonia Bünter1, Clemens Dahinden3, Werner J. Pichler1,2, Oliver Hausmann1,2

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1

09.35 – 09.55



OP 6 Anti-apolipoprotein A1 autoantibodies induce tissue factor activity and expression: a role in atherothrombosis. Sabrina Pagano1,2, Julien Virzi1,2, Nathalie Satta1,2, Tiphaine Mannic1,2, Pascale Roux-Lombard1,3, François Mach4, Fabrizio Montecucco1,2,4, Nicolas Vuilleumier1,2 1 Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Switzerland 2 Department of Human Protein Sciences, Faculty of Medicine, Geneva, Switzerland. 3 Division of Immunology and Allergy, Department of Internal Medicine, Geneva University Hospitals, Switzerland. 4 Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland

09.55 – 10.15

OP 7 Over-representation of IL-17A positive mastocytes and IL-17E positive macrophages in lesional skin of psoriatic patients Nicolò C. Brembilla1,2, Romaine Stalder1,2, Lionel Fontao1, Gurkan Kaya2, Carlo Chizzolini2,3 and Wolf-Henning Boehncke1,2. 1 Dermatology and 3 Immunology & Allergy, University Hospitals of Geneva, Geneva, Switzerland; 2 Department of Pathology and Immunology, School of Medicine, University of Geneva, Geneva, Switzerland

10.15 – 10.45

OP 8 Th17 cells and tissue remodeling in atopic and contact dermatitis Dagmar Simon1, Carla Aeberhard2, Yeliz Erdemoglu1, HansUwe Simon2









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ADR-AC GmbH, Holligenstrasse, 3008 Bern Department of Rheumatology, Immunology and Allergology 3 Institute of Immunology, Inselspital, University of Bern, 3010 Bern 2





Department of Dermatology, Inselspital, Bern University Hospital, and 2 Institute of Pharmacology, University of Bern, Bern, Switzerland 1

09.15 – 10.45 Oral communications ______________________ Room Wisshorn Clinical allergy and aerobiology Chairs: Madeleine Bauer (Olten), Kathrin Scherer (Basel)

15 min Presentation plus 5 min Discussion /Abstract

09.15 – 09.35

OP 9 Gamma-linolenic acid levels correlate with Clinical efficacy of evening primrose oil in patients with atopic dermatitis Dagmar Simon1, Peter A. Eng2, Siegfried Borelli3, Roland Kägi4, Christian Zimmermann5, Catherine Zahner5, Jürgen Drewe5, Lorenzo Hess6, Giovanni Ferrari7, Stephan Lautenschlager3, Brunello Wüthrich8, Peter Schmid-Grendelmeier7 1 Department of Dermatology, Inselspital, University, Hospital of Bern, Bern, Switzerland 2 Children’s Hospitals Aarau and_ Lucerne, Aarau and Lucerne, Switzerland 3 Outpatient Clinic of Dermatology, Triemli Hospital, Zurich, Switzerland 4 Pediatric Practice at Rigiplatz, Zurich, Switzerland 5 Max Zeller Söhne AG, Romanshorn, Switzerland 6 Brunner & Hess Software AG, Zurich, Switzerland 7 Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland 8 Hospital Zollikerberg, Zollikerberg, Switzerland

09.35 – 09.55

OP 10 Aerobiological survey of ragweed (Ambrosia artemisiifolia) expansion in the Geneva area: a tool for the control of the plant Pierre Gumowski1, Marie-José Graber2, Frédérique Van Eck1, Maud Echenard1, Bernard Clot2

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INRAAIC, Allergology & Immunology Dept., Hôpital de la Tour, Meyrin, Switzerland 2 MeteoSwiss, Payerne, Switzerland 1

09.55 – 10.15

OP 11 Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population Brunello Wüthrich1, Peter Schmid-Grendelmeier2, Christian Schindler3, Medea Imboden3, Andreas Bircher4, Elisabeth Zemp3, Nicole Probst-Hensch and the SAPALDIA study team

10.15 – 10.45

OP 12 Testing automated pollen monitors in comparison with the Hirst-type trap Natalie Lemonis1, Toshio Fujita2, Ulrich Heimann3, Shigeto Kawashima4, Rouven Möller3, David O’Connor5, John Sodeau5, Bernard Clot1 1 MeteoSwiss, Payerne, Switzerland; 2 Yamato Engineering Company Ltd., Yokosuka, Japan; 3 Helmut Hund GmbH, Wetzlar, Germany; 4 University of Kyoto, Japan; 5 Department of Chemistry, University College Cork, Ireland

10.45 – 11.15 Coffee break 11.15 – 12.45

Symposium V ________________________________ Room Sanada Infection and Allergy Chairs: Peter Schmid-Grendelmeier (Zurich), Annette Oxenius (Zurich)

11.15 – 11.45 Microbiome and food allergy: where is the link? Liam O‘Mahony (Davos) 11.45 – 12.15 Worms and allergy: fear or friend? Ronald van Ree (Netherlands) 12.15 – 12.45 Streptococal disease: infection, inflammation and or cross reactivity? Annelise Zinkernagel (Zurich)

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11.15 – 12.45 Forum der Praktiker ________________________ Room Seehorn Chairs: Louis-François Debétaz (Lausanne), Myriam Wyss (Meilen) 11.15 – 12.00 Allergy prevention in childhood – has everything changed now? Caroline Roduit (Zurich) 12.00 – 12.45 Anaphylaxis education – new concepts Alice Köhli (Zurich), Angelica Dünner (Zurich) 12.55 – 13.55

Lunch Symposium 2 _________________________ Room Sanada What’s new for Omalizumab? Current and future developments (sponsored by Novartis Pharma Schweiz AG) Chair: Peter Schmid-Grendelmeier (Zurich)



Experiences with Omalizumab: New Real-Life Data Jörg Leuppi, (Basel)



Diagnosis and Management of Chronic Spontaneous Urticaria Peter Schmid-Grendelmeier (Zurich)



Clinical development of Omalizumab in Chronic Spontanous Urticaria Oliver Hausmann (Bern)

14.00 – 15.30 Symposium VI ______________________________ Room Sanada Vasculitis: from pathomechanism to therapy Chairs: Onur Boyman (Zurich), Thomas Hauser (Zurich) 14.00 – 14.30 Hepatitis C virus and vasculitis Darius Moradpur (Lausanne) 14.30 – 15.00 IL-2 immunotherapy of HCV-associated vasculitis David Saadoun (France) 15.00 – 15.30 Treatment of autoimmune vasculitis David Jayne (United Kingdom) 25

14.00 – 15.30 Oral communications _______________________ Room Seehorn Investigational allergy and immunology Chairs: Thomas Kündig (Zurich), Burkhard Becher (Zurich)

15 min Presentation plus 5 min Discussion /Abstract

14.00

OP 13 Ultra-fast hypoallergenic Birch pollen allergy vaccine AllerT is efficient and safe: Results of a Phase IIb study François Spertini1, Frédéric de Blay2, Lars Jacobsen3, Marek Jutel4, Margitta Worm5, Gilles Della Corte6, Alexander Kettner6, Vincent Charlon6 and Christophe Reymond6 1 Division of Immunology and Allergy, CHUV, Lausanne, Switzerland; 2 Division of Pneumology, Strasbourg, France; 3 ALC Copenhagen, Denmark; 4 Wroclaw Medical University, Wroclaw, Poland; 5 Allergie Zentrum, La Charité, Berlin, Germany; 6 Anergis SA, Epalinges, Switzerland



14.20



14.40

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OP 14 Correlation of sting challenge outcome and change in EC50 in basophil activation test (BAT) in bee venom allergic patients after 2-5 years of venom immuntherapy Oliver Hausmann1,4, Michael Schneider2, Jakob Weber2, Tatjana Pecaric Petkovic3, Carolina Diaz3, Arthur Helbling1,4 1 Department of Rheumatology, Allergology and Clinical Immunology, Inselspital, University Hospital, Bern (CH) 2 BÜHLMANN Laboratories AG, Schönenbuch (CH) 3 ADR-AC GmbH, Holligenstrasse, 3008 Bern (CH) 4 Div. of Allergology, SpitalNetzBern, Zieglerspital, Bern (CH) OP 15 Compartmentalisation of microbiota dynamics and function along the intestinal tract Hai Li, Melissa Lawson, Markus Geuking, Kathy McCoy, Andrew Macpherson, Maurice Müller Laboratories, DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital (Inselspital), University of Bern, Switzerland

15.00

OP 16 Probiotics stabilize IL-10 mRNA expression: a role for mircoRNAs? Audrey Demont1, Feriel Hacini-Rachinel1, Remi Doucet1, Catherine Ngom Bru1 and Carine Blanchard1 1 Nestle Research Center, Lausanne, Switzerland

14.15 – 16.45 Allergie-Symposium für Pflegende und MPA ____________________ Room Wisshorn Chair: Sandra Beeler (Zurich) 14.15 – 15.30 Teil I 14.15 – 14.50 Molekulare Allergiediagnose – ganz praktisch Thomas Harr (Geneva) 14.50 – 15.10 Mikroschulung zur Förderung der Adhärenz bei Patienten mit Desensibilisierungstherapie Karin Grando (Zurich) 15.10 – 15.30 Allergien und gesundes Körpergewicht Sereina Maibach (Bern) 15.30 – 16.00 Kaffeepause 16.00 – 16.45 Teil II Vorgehen bei Anaphylaxie Alice Köhli (Zurich), Sandra Beeler (Zurich) 15.30 – 16.00 Coffee break 16.00 – 16.15

Award ceremony _ ___________________________ Room Sanada Chair: Peter Schmid-Grendelmeier (Zurich) Brunello Wüthrich Allergy Poster Prize (CHF 1’000) for the best allergy case description Biotest (Schweiz) AG (CHF 1’000) for the best contribution in clinical immunology SSAI two prices (each CHF 1’000) for the best contribution in experimental immunology and allergy 27

16.15 – 17.45 Symposium VII _____________________________ Room Sanada Treatment: what is new? Chairs: Andreas Bircher (Basel), Jörg Seebach (Geneva) 16.15 – 16.40 Update Asthma therapy Michael Tamm (Basel) 16.40 – 17.00 Therapeutic molecules Alexander Eggel (Bern) ACTERIA Prize Winner 2013 17.00 – 17.20 News in HAE management Petra Staubach (Germany) 17.20 – 17.45 Specific immunotherapy Thomas Kündig (Zurich) 17.45 – 18.00 Closure of the meeting _______________________ Room Sanada Peter Schmid-Grendelmeier (Zurich)

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WIRM Program March 19 – 22, 2014 MAIN PROGRAMME World Immune Regulation Meeting VIII, 19 - 22 March 2014, Davos Switzerland

1. DAY - Wednesday, 19 March 2014 - Plenary Hall Davos 1 1. DAY

Innate Immune Response and Immunological - Wednesday, 19 MarchMemory 2014 - Plenary Hall Davos 1

Innate Immune Response and Immunological Memory. Essentials of immune regulation in the innate immune response Essentials of immune in the innate Cezmi regulation Akdis, Hans-Uwe Simon immune response Chairs Cezmi Akdis, Hans-Uwe Simon Chairs 08:30 - 09:00 Florent Ginhoux The embryonic origin of tissue-resident macrophages 08:30- -09:30 09:00 Kenneth Florent M. Ginhoux The Embryonic Origin ofdendritic Tissue-Resident Macrophages 09:00 Murphy Roles for tissue resident cell subsets in immune responses 09:00- -10:00 09:30 09:30 09:30 - 10:00 10:00 - 10:15 10:00 - 10:15 10:15 - 10:30 10:15 - 10:30 10:30 - 11:00 10:30 - 11:00

Kenneth M. Murphy Roles for tissue resident dendriticregulating cell subsets in immune responses Shizuo Akira Regnase-1, an endoribonuclease the immune response Shizuo Akira Regnase-1, an endoribonuclease the immune response IL-23 production by CD11c+ CD64+regulating mononuclear phagocytes drives chronic Helicobacter hepaticus-induced Isabelle Arnold IL-23 production by CD11c+ CD64+ mononuclear phagocytes drives chronic Helicobacter hepaticus-induced intestinal inflammation Isabelle Arnold inflammation Andrew Croxford Tintestinal cell-derived GM-CSF instructs CCR2+ myeloid cells to induce autoimmune inflammation Andrew Croxford T cell-derived GM-CSF instructs CCR2+ myeloid cells to induce autoimmune inflammation Coffee break Coffee break Development of immunological memory I Development of Kurt immunological memory I Blaser, Federica Sallusto Chairs

Chairs 11:00 - 11:30 Francis 11:00- -12:00 11:30 Michael FrancisJ. 11:30 11:30- -12:30 12:00 Dirk Michael 12:00 H. J. 12:00- -13:00 12:30 12:30 12:30 - 13:00 13:00 - 15:30 13:00 - 15:30 15:30 - 16:30 15:30 - 16:30 16:30 - 16:50 16:30 - 16:50 16:50 - 17:00

Kurt Blaser, FedericaGeneration Sallusto and function of tissue resident memory T cells Carbone Carbone Generationcontraction and function tissue resident memory T cells Bevan Expansion, andofmemory formation of T cells

Bevan Expansion, contraction and Tmemory formation ofonTthe cells Busch Effector and memory CD8(+) cell differentiation single cell level Dirk H. Busch Effectorlearned and memory CD8(+) immunodeficiencies T cell differentiation on the single cell level Bodo Grimbacher Lessons from primary Bodo Grimbacher Lessons learned from primary immunodeficiencies Lunch break Lunch break Workshops 1 - 4 (please see workshop programme) Workshops 1 - 4 (please see workshop programme) Coffee break Coffee break Cezmi Akdis Opening Address

16:50 - 17:00 Cezmi Akdis Opening Address Development of immunological memory II Development of Roger immunological memory II Lauener, Peter Schmid-Grendelmeier Chairs Chairs 17:00 - 17:30 Phil

Roger Lauener, PeterSingle Schmid-Grendelmeier Hodgkin cell fates and pedigree analysis in the development of memory

17:30 17:00- -18:00 17:30 Andreas Phil

Radbruch Hodgkin

TSingle cell memory in the marrow cell fates andbone pedigree analysis in the development of memory

18:00 17:30- -18:30 18:00 Frank Andreas

Nestle Radbruch

From to function and marrow therapy in inflammatory skin disease T cellgenes memory in the bone

18:00- -18:45 18:30 Elisabetta Frank 18:30

Nestle Padovan

From genes to functionnonclassical and therapymonocytes in inflammatory skin disease Human CD14+CD16++ negatively impact on Th17 expansion through LFA-1

18:45 18:30- -19:00 18:45 Aleksandra Elisabetta

Ozga Padovan

Dynamic control of T cell nonclassical activation by monocytes peptide affinity Human CD14+CD16++ negatively impact on Th17 expansion through LFA-1

18:45 - 19:00 Aleksandra 19:00 - 19:15 Kenji

Ozga Kabashima

ToDynamic reveal the motility of tissue-resident memory T cells (TRM) in the skin by developing a novel murine control of Tand cellroles activation by peptide affinity model of fixed drug eruption To reveal the motility and roles of tissue-resident memory T cells (TRM) in the skin by developing a novel murine

19:00 - 19:15 Kenji Kabashima model of fixed drug eruption 19:30 - 22:00 Poster Sessions 1 - 7 (please see poster programme) - 4, Main Corridor Posterpresentations Sessions 1 -of7 workshops (please see1poster programme) 19:30 - 22:00 Poster

Poster presentations of workshops 1 - 4

DAY- -Thursday, Thursday,2020March March2014 2014- -Plenary PlenaryHall HallDavos Davos1 1 2.2.DAY

Metabolism and Microbiome in Immune Regulation. Metabolism and Microbiome in Immune Regulation

29

16:30 - 16:50 Coffee break 16:50 - 17:00 Cezmi

Akdis

Opening Address

Development of immunological memory II Chairs

Roger Lauener, Peter Schmid-Grendelmeier

17:00 - 17:30 Phil

Hodgkin

Single cell fates and pedigree analysis in the development of memory

17:30 - 18:00 Andreas

Radbruch

T cell memory in the bone marrow

18:00 - 18:30 Frank

Nestle

From genes to function and therapy in inflammatory skin disease

18:30 - 18:45 Elisabetta

Padovan

Human CD14+CD16++ nonclassical monocytes negatively impact on Th17 expansion through LFA-1

18:45 - 19:00 Aleksandra

Ozga

Dynamic control of T cell activation by peptide affinity

19:00 - 19:15 Kenji

Kabashima

To reveal the motility and roles of tissue-resident memory T cells (TRM) in the skin by developing a novel murine model of fixed drug eruption

19:30 - 22:00 Poster Sessions 1 - 7 (please see poster programme) Poster presentations of workshops 1 - 4, Main Corridor

MAIN PROGRAMME World Immune Regulation Meeting VIII, 19 - 22 March 2014, Davos Switzerland

2. DAY - Thursday, 20 March 2014 - Plenary Hall Davos 1 1. DAY

Metabolism and Microbiome in Immune Regulation - Wednesday, 19 March 2014 - Plenary Hall Davos 1

Innate Immune Response and Immunological Memory. Microbiome-immune interactions Essentials of immune regulation in the innate immune response Liam O'Mahony, Annelies Zinkernagel Chairs Cezmi Akdis, Hans-Uwe Simon Chairs 08:30 - 09:00 David Artis Host-microbe interactions in health and disease 08:30- -09:30 09:00 Yasmine Florent Ginhoux The Embryonic Origininteractions of Tissue-Resident 09:00 Belkaid Microbiome-immune in the skinMacrophages 09:00- -10:00 09:30 09:30 09:30- -10:30 10:00 10:00

Kenneth M. Benjamin ShizuoS. Richard

10:00 - 10:15 Isabelle 10:30 - 11:00 Coffee break

Murphy Marsland Akira Blumberg Arnold

Roles for tissue resident dendriticin cell Microbiome-immune interactions the subsets airways in immune responses Regnase-1, an endoribonuclease Microbiome-immune interactions inregulating the gut the immune response IL-23 production by CD11c+ CD64+ mononuclear phagocytes drives chronic Helicobacter hepaticus-induced intestinal inflammation

10:15 - 10:30 Andrew Croxford T cell-derived GM-CSF instructs CCR2+ myeloid cells to induce autoimmune inflammation Metabolism and immune response I Coffee break Manfred Kopf, Claudio Rhyner 10:30 - 11:00 Chairs 11:00 - 11:30 Gökhan Hotamisligil Immunometabolism of obesity and diabetes 11:30 - 12:00 Giuseppe Nutrient Development of Matarese immunological memory I sensing in Tregs via mTOR hydrocarbon receptor signaling controls organogenesis of intestinal lymphoid follicles Kurt Blaser, FedericaAryl Sallusto Chairs 12:00 - 12:15 Elina Kiss ACTERIA PRIZE WINNER 11:00 - 11:30 Francis Carbone Generation and function of tissue resident memory T cells break 12:15 11:30- -14:30 12:00 Lunch Michael J. Bevan Expansion, contraction and memory formation of T cells 12:00 - 12:30 Dirk H. Busch Effector and memory CD8(+) T cell differentiation on the single cell level 14:30 - 16:00 Workshops 5 - 8 (please see workshop programme) 12:30 - 13:00 Bodo Grimbacher Lessons learned from primary immunodeficiencies SPECIAL LECTURE Lunch break 13:00- -17:15 15:30 Oswald 16:15 Oelz The summits of the world and life Workshops 15:30- -17:40 16:30 Coffee break 1 - 4 (please see workshop programme) 17:15 CoffeeCeremony break for poster prizes of day 1 and workshop prizes of workshops 1 - 4 16:30- -17:45 16:50 Award 17:40 and immune 16:50 - 17:00 Metabolism Cezmi Akdis response II Opening Address Gökhan Hotamisligil, Jean-Michel Dayer Chairs Development of Pearce immunological memory II regulation of T cell function and fate 17:45 - 18:15 Erika Metabolic

Chairs 18:15 - 18:45 Ajay 17:00- -19:15 17:30 Manfred Phil 18:45 17:30 19:30 - 18:00 Marie Andreas 19:15-

Roger Lauener, PeterAnticipatory Schmid-Grendelmeier Chawla inflammation: physiologic functions and pathologic consequences Hodgkin Single cell fatesand andthioredoxin pedigree analysis development of and memory Kopf The glutathione systemsininthe T cell homeostasis immunity

Radbruch T cellcellular memory in the bone marrow Bettonville Low metabolism does not preclude effector function in chronically stimulated CD4 T cells 18:00 - 18:30 Frank Nestle From genes to function and therapy in inflammatory skin disease 19:30 - 22:00 Poster sessions 8 - 14 (please see poster programme) 18:30 - 18:45 Elisabetta Padovan Human CD14+CD16++ nonclassical monocytes negatively impact on Th17 expansion through LFA-1 Poster presentations of workshops 5 - 8, Main Corridor 18:45 - 19:00 Aleksandra Ozga Dynamic control of T cell activation by peptide affinity 19:00 - 19:15 Kenji

Kabashima

To reveal the motility and roles of tissue-resident memory T cells (TRM) in the skin by developing a novel murine model of fixed drug eruption

19:30 - 22:00 Poster Sessions 1 - 7 (please see poster programme) Poster presentations of workshops 1 - 4

30 2. DAY - Thursday, 20 March 2014 - Plenary Hall Davos 1 Metabolism and Microbiome in Immune Regulation.

MAIN PROGRAMME World Immune Regulation Meeting VIII, 19 - 22 March 2014, Davos Switzerland

3. DAY - Friday, 21 March 2014 - Plenary Hall Davos 1 1. DAY

Inflammasome | Innate lymphoid 19 cellsMarch | Immune2014 pathology - Wednesday, - Plenary Hall Davos 1

Innate Immune Response and Immunological Memory. The inflammasome in the memory of Dr. Jürg Tschopp Essentials of immune regulation in theEigenmann innate immune response Greta Guarda, Philippe Chairs Cezmi Akdis, Hans-Uwe Simon Chairs 08:30 - 09:00 Richard Flavell Inflammasomes in health, dysbiosis, and disease 08:30- -09:30 09:00 Lars Florent Ginhoux Theinflammasome Embryonic Origin Tissue-Resident Macrophages 09:00 E. French The and ofIL-1β: clinical implications beyond genetic autoinflammatory diseases 09:00- -10:00 09:30 09:30 09:30 - 10:00 10:00 - 10:30 10:00 - 10:15

Kenneth M. Murphy Roles for tissue resident dendritic cellinsubsets in immune responses Stefan Freigang Inflammasome-independent IL-1alpha metabolic inflammation Shizuo Akira Regnase-1, an endoribonuclease regulating the immune response Coffee break IL-23 production by CD11c+ CD64+ mononuclear phagocytes drives chronic Helicobacter hepaticus-induced Isabelle Arnold intestinal inflammation Innate lymphoid cells 10:15 - 10:30 Andrew Croxford T cell-derived GM-CSF instructs CCR2+ myeloid cells to induce autoimmune inflammation Markus Manz, Antonius Rolink Chairs

10:30 Coffee break 10:30- -11:00 11:00 Frits

Koning

Novel ILC like cells in the gut

11:00 - 11:30 Hergen Spits Regulation of development and function of human ILC Development of immunological memory I 11:30 - 12:00 Eric Vivier Novel NK cell subsets and functions Kurt Blaser, Federica Sallusto Chairs 12:00 - 12:15 Zsolt Komlosi A type 3 innate lymphoid cell subset induces IL-10-producing B cell differentiation 11:00 - 11:30 Francis Carbone Generation and function of tissue resident memory T cells 12:15 - 12:30 Jenny Mjösberg Characterization of innate lymphoid cells (ILC) in the human liver reveals a role for ILC2 in liver fibrosis 11:30 - 12:00 Michael J. Bevan Expansion, contraction and memory formation of T cells break 12:30 12:00- -15:00 12:30 Lunch Dirk H. Busch Effector and memory CD8(+) T cell differentiation on the single cell level

12:30 - 13:00 Bodo Grimbacher Lessons learned from primary immunodeficiencies 15:00 - 16:30 Workshops 9 & 11 (please see workshop programme) 10 & 12 (please see workshop programme) 15:30 Lunch break 13:00- -16:30 15:30 Workshops break 1 - 4 (please see workshop programme) 16:30 Workshops 15:30- -16:55 16:30 Coffee 16:55 CoffeeCeremony break for poster prizes of day 2 and workshop prize of workshops 5 - 8 16:30- -17:00 16:50 Award pathology 16:50 - 17:00 Regulation Cezmi of immune Akdisresponse and immune Opening Address Reto Crameri, Ronald van Ree Chairs Development of immunological memory II 17:00 - 17:30 Adriano Aguzzi Mechanisms of prion-induced toxicity

Chairs 17:30 - 18:00 Petter 17:00- -18:30 17:30 Reinhold Phil 18:00 17:30 - 18:00 Andreas 18:30 - 18:45 Nicolas 18:00 - 18:30 Frank 18:45 18:30- -19:00 18:45 Burkhard Elisabetta

Roger Lauener, PeterSeparating Schmid-Grendelmeier Brodin heritable and non-heritable influences in the human immune system Hodgkin Single cell fates and pedigree analysisininlymphoid the development of memory Förster Chemokines and chemokine receptors organ organogenesis Radbruch Manel Nestle Ludewig Padovan

T cell immune memory sensing in the bone marrow Innate of HIV by human dendritic cells ACTERIA PRIZE WINNERand therapy in inflammatory skin disease From genes to function Extra-lymphatic CCR7-ligand expression controls virus-induced CNSon inflammation Human CD14+CD16++ nonclassical monocytes negatively impact Th17 expansion through LFA-1

18:45- -22:00 19:00 Poster Aleksandra control of T cell activation by peptide affinity sessions 15 Ozga - 19 (please see posterDynamic programme) 19:30 ToMain reveal the motility and roles of tissue-resident memory T cells (TRM) in the skin by developing a novel murine Poster presentations of workshops 9 16, Corridor 19:00 - 19:15 Kenji Kabashima model of fixed drug eruption 19:30 - 22:00 Poster Sessions 1 - 7 (please see poster programme) Poster presentations of workshops 1 - 4

4. DAY - Saturday, 22 March 2014 - Plenary Hall Davos 1 Autoimmunity, B cell regulation, Anti-Tumor Immune Response

2. DAY - Thursday, 20 March 2014 - Plenary Hall Davos 1

Metabolism andAutoimmunity Microbiome in Immune Regulation.

31

15:30 - 16:30 Workshops 10 & 12 (please see workshop programme) 16:30 - 16:55 Coffee break 16:55 - 17:00 Award Ceremony for poster prizes of day 2 and workshop prize of workshops 5 - 8 Regulation of immune response and immune pathology Chairs

Reto Crameri, Ronald van Ree

17:00 - 17:30 Adriano

Aguzzi

Mechanisms of prion-induced toxicity

17:30 - 18:00 Petter

Brodin

Separating heritable and non-heritable influences in the human immune system

18:00 - 18:30 Reinhold

Förster

18:30 - 18:45 Nicolas

Manel

18:45 - 19:00 Burkhard

Ludewig

Chemokines and chemokine receptors in lymphoid organ organogenesis Innate immune sensing of HIV by human dendritic cells ACTERIA PRIZE WINNER Extra-lymphatic CCR7-ligand expression controls virus-induced CNS inflammation

19:30 - 22:00 Poster sessions 15 - 19 (please see poster programme) Poster presentations of workshops 9 - 16, Main Corridor

MAIN PROGRAMME World Immune Regulation Meeting VIII, 19 - 22 March 2014, Davos Switzerland

4. DAY - Saturday, 22 March 2014 - Plenary Hall Davos 1 1. DAY

Autoimmunity,- BWednesday, cell regulation, Anti-Tumor Immune 19 March 2014Response - Plenary Hall Davos 1

Innate Immune Response and Immunological Memory. Autoimmunity Essentials of immune regulation theBoyman innate immune response Francois Spertini, in Onur Chairs Cezmi Akdis, Hans-Uwe Simon Chairs 08:30 - 09:00 Kerstin Wolk Key mediators of epithelial alterations in psoriasis 08:30- -09:30 09:00 Bart Florent Ginhoux The Embryonic Origin ofimmune Tissue-Resident Macrophages 09:00 Roep Natural and therapeutic regulation in type 1 diabetes 09:00 - 09:30 Kenneth M. 09:30 - 09:45 Avidan 09:30 - 10:00 Shizuo

Murphy Neumann Akira

Roles for Ttissue resident dendritic cell by subsets in immuneNext responses Individual cell clones kinetics tracked TCR repertoire Generation Sequencing show rich and differential conventional versus regulatory response to IL2the in-vivo Regnase-1, an endoribonuclease regulating immune response

10:00- -10:15 10:15 Coffee Isabelle 09:45 break

Arnold

IL-23 production by CD11c+ CD64+ mononuclear phagocytes drives chronic Helicobacter hepaticus-induced intestinal inflammation

10:15 - 10:30 BAndrew cell regulation Croxford Chairs 10:30 - 11:00 Coffee break 10:15 - 10:45 Michael

T cell-derived GM-CSF instructs CCR2+ myeloid cells to induce autoimmune inflammation

Mübeccel Akdis, Antonio Lanzavecchia McHeyzer-Williams Intraclonal analysis of memory B cell fate

Development of Schwartzberg immunological memory I and negative signalling through SLAM receptors regulate T:B cell interactions 10:45 - 11:15 Pamela L. Positive 11:15 - 11:30 David Chairs

11:00- -11:45 11:30 Joke Francis 11:30 11:30 - 12:00 Michael J. 12:00- -12:00 12:30 11:45 12:30 - 13:00 12:00 - 15:00 13:00 - 15:30 15:00 - 16:00 15:30 - 16:30 subsequently

Kurt Blaser, FedericaBSallusto Voehringer cell-intrinsic STAT6 controls the geminal center response in type 2 immunity Splenic CD169+ deliver antigens to follicular Carbone Generation and macrophages function of tissue resident memory T cellsdendritic cells and stimulate germinal center B cell Den Haan responses Bevan Expansion, contraction and memory formation of T cells

Dirk H. differentiation Award Ceremony forBusch lottery, poster prizes Effector of day 3 and and memory workshopCD8(+) prizes Tof cell workshops 9 - 12 on the single cell level Bodo Grimbacher Lessons learned from primary immunodeficiencies Lunch break Lunch break Workshops 13 - 16 (please see workshop programme) Workshops 1 - 4for(please see workshop programme) Award Ceremony workshop prizes of workshops 13 - 16 (will be given directly in the workshop rooms)

Coffeebreak break 16:30- -16:30 16:50 Coffee 16:00 16:50 - 17:00 Immune Cezmi regulationAkdis Opening Address in anti-tumor immune response Burkhard Ludewig, Pedro Romero Chairs Development of immunological memory II 16:30 - 17:00 Douglas Fearon Stromal microenvironment in tumoral immune suppression Roger Lauener, Peter Schmid-Grendelmeier Chairs 17:00 - 17:30 Sergio A. Quezada Targeting immune checkpoints in cancer: new mechanistic insights 17:00 - 17:30 Phil Hodgkin Single cell fates and pedigree analysis in the development of memory Langerin+ dendritic cells can initiate anti-tumoral CD8+ T cell responses in a mouse model of spontaneous 17:30 Stoitzner 17:30- -17:45 18:00 Patrizia Andreas Radbruch T cell memory in the bone marrow melanoma 17:45 18:00- -18:00 18:30 Marco Frank

Nestle Lepore

to function therapy in Tinflammatory disease AFrom novelgenes self-lipid antigen and targets human cells againstskin CD1c+ leukaemias

18:30 - 18:45 Elisabetta 18:00 - 18:10 Cezmi 18:45 - 19:00 Aleksandra

Padovan Akdis Ozga

Human CD14+CD16++ nonclassical monocytes negatively impact on Th17 expansion through LFA-1 Closing Address Dynamic control of T cell activation by peptide affinity

20:00 Dinner & Dance Gala Night 19:00 - 19:15 Kenji Kabashima

To reveal the motility and roles of tissue-resident memory T cells (TRM) in the skin by developing a novel murine model of fixed drug eruption

19:30 - 22:00 Poster Sessions 1 - 7 (please see poster programme) Poster presentations of workshops 1 - 4

32 2. DAY - Thursday, 20 March 2014 - Plenary Hall Davos 1 Metabolism and Microbiome in Immune Regulation.

 

  The ACTERIA Prizes consist of four prizes being  awarded  by  the  European  Federation  of  Immunological Societies (EFIS) for the first time  at  the  2013  International  Congress  of  Immunology  and  thereafter  tri‐annually  at  the  European  Congress  of  Immunology  (ECI),  starting  at  the  2015  ECI  in  Vienna.  These  four  prizes  shall  distinguish  high  potential  early  career  researchers,  two  each  in  Immunology  and  Allergology  to  acknowledge  outstanding  achievement  in  fundamental  research  in  an  institute  from  a  European  country  during  doctoral  thesis  in  the  last  3  years  (ACTERIA  Doctoral Thesis Prizes) and early career research  up to 10 years after PhD (ACTERIA Early Career  Research  Prizes).  European  countries  are  defined  as  those  where  an  immunological  or  allergological  society  is  affiliated  to  EFIS.  EFIS  will  announce  will  announce  the  prizes  to  national  societies  in  October  and  December  before  each  ECI  year.  Nominations  for  the  ACTERIA  Prizes  are  to  be  submitted  to  EFIS  by  an EFIS member in good standing in accordance  with  the  ACTERIA  Prizes  Rules.  Nominations  shall include a nomination letter, an application  form and ethical approvals. 

 

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Chairpersons and speakers Akdis Cezmi Anliker Mark Aubert Vincent Ballmer-Weber Barbara Bauer Madeleine Becher Burkhard Beeler-Trüssel Sandra Bircher Andreas Boyman Onur Chizzolini Carlo Clarenbach Christian Debétaz Louis-François Distler Oliver Dünner Angelica Eggel Alexander* Eigenmann Philippe Eyerich Stefanie* Fischer Axel French Lars E. Genser Julia Grando Karin Haniffa Muzlifah Harder Dominik Harr Thomas Hauser Thomas Hausmann Oliver Heijnen Ingmar Hötzenecker Wolfram Jayne David Kiss Elina* Klimek Ludger Köhli Alice Kopf Manfred Kündig Thomas Lidholm Jonas Ludewig Burkhard

Maibach Sereina Manel Nicolas* Moradpur Darius Müller Christoph Ollert Markus O’Mahony Liam Oxenius Annette Pachlopnik Jana Pauling Andreas Petrausch Ulf Pichler Werner Joseph Poulsen Lars Puel Anne Regenass Stephan Reichenbach Janine Roduit Caroline Rothe Thomas Saadoun David Sallusto Federica Sargur Ravishankar Schäppi Georg Scherer Kathrin Schmid-Grendelmeier Peter Seebach Jörg Simons Estelle Soyka Michael Speiser Daniel Spertini François Steiner Urs Tamm Michael van der Burg Mirjam van Ree Ronald Weber Christina Weibel Lisa Wyss Myriam Zinkernagel Annelise * ACTERIA Prize winners 2013

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Sponsors Lunch Symposia:

MEDA Pharma GmbH



Novartis Pharma Schweiz AG

Bronze Sponsor:

CSL Behring, Bern

Sponsors of various contributions:

Allergopharma AG



A. Menarini AG



Biotest (Schweiz) AG



MEDA Pharma GmbH



Roche Pharma (Schweiz) AG



Stallergenes AG



Thermo Fischer Scientific/ Phadia AG

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Exhibitors Allergopharma AG

Therwil

A. Menarini AG

Zurich

aha! Allergiezentrum Schweiz

Bern

ALK-ABELLO AG

Volketswil

BAG Bundesamt für Gesundheit

Bern

Baxter AG

Volketswil

Biotest (Schweiz) AG

Rupperswil

CK-Care

Davos

CSL Behring

Bern

EUROIMMUN Schweiz AG

Lucerne

Forschung für Leben

Zurich

GlaxoSmithKline (GSK) AG

Münchenbuchsee

HAE Vereinigung Schweiz

Kriens

MEDA Pharma GmbH

Wangen-Brüttisellen

Novartis Pharma Schweiz AG

Rotkreuz

Thermo Fischer (Phadia) AG

Steinhausen

Pro Farma AG

Baar

R&D Systems Europe Ltd.

Oxon, UK

RUWAG Handels AG

Bettlach

Shire Human Genetic Therapies

Montreux

Stallergenes AG

Dietlikon

Teomed AG

Greifensee

VITARIS AG

Baar

Schweizerische Lupus Erythematodes Vereinigung (SLEV)

Dietlikon

SchweizerischeVereinigung für angeborene Immundefekte (SVAI)

Zurich

Viropharma LLC

Zurich

Zeller Medical AG

Romanshorn

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Map Congress Centre Davos

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Meeting Information ACTERIA Fondation The winners of the ACTERIA Prizes 2013 awarded by the European Federation of Immunological Societies (EFIS) are presenting their work at the 2014 SSAI Annual Congress or at the WIRM: The four young researchers have been awarded for their outstanding scintific contributions: ACTERIA Doctoral Thesis Award in Allergology (SSAI congress) Dr. Alexander Eggel, Institute of Immunology, University Bern Email [email protected] ACTERIA Early Career Research Award in Allergology (SSAI congress) Dr. Stefanie Eyerich, Technical University and Helmholtz Center Munich, Germany Email: [email protected] ACTERIA Early Career Research Award in Immunology (WIRM) Nicolas Manel, Institute Curie, Paris, France Email: [email protected] ACTERIA Doctoral Thesis Award in Immunology (WIRM) Dr. Elina Kiss, University of Freiburg, Germany Email: [email protected] Admission to sessions Admission to the sessions is reserved for meeting registrants and registered members of the press only. Guests and non-registered exhibitors will not be admitted to any scientific session. Children and Guests We kindly ask delegates to refrain from taking children, spouses or guests to any educational session. Registered accompanying persons are welcome to visit the booth area and poster sessions. Children under the age of 18 must be accompanied by an adult at all times.

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Credits Swiss Society for Allergology and Immunology 16 Credits A personal certificate will be handed out with the congress badge at the registration desk. WIRM/SSAI 2014 has official been accepted for 2 credits animal health (Tierversuchsweiterbildung). Davos Davos is worldwide known as congress city, home of several research institutes and as a winter sports paradise. With 1´560 meters above see level it is the highest situated city of the Alps. The combination of idyllic alpine landscape, urban atmosphere and the wide range of service, infrastructure, fine food and activities is unique. Please visit the stand of «Davos Services» next to the registration desk to get inspired. Gala Dinner at Schatzalp Schatzalp is car-free. From the center of Davos Platz, you can reach it with the local cable car in 4 minutes. The time schedule will be adapted accordingly. Your registration for the Gala Dinner includes the ride with the cable that is offered by SSAI. With your congress badge a voucher for the Gala Dinner if handed out. Gala Diner at Schatzalp starts at 8 pm. Jobcenter www.wirm.ch Because of the dense scientific community at the WIR Meeting, this is an ideal opportunities also for SSAI members to apply for open positions or to find highly motivated fellows. The entire service is free of charge. If you would like to advertise your job offer, please submit your advertisement as WORD or PDF file to [email protected]. If you are looking for an open position, browse our job offers at www.wirm.ch. If you would like to reserve a room for an interview, please ask our staff at the registration desk. 39

Lost and Found There is a lost and found table at the registration desk. Meeting room policy No video equipment, cameras, audio equipment or any other type of recording device will be allowed during all scientific sessions. No Smoking Smoking is prohibited at the entire Congress Center and during all sessions and events. Poster presenter information Poster presenters are asked to mount their posters until 10:00 on the presenting day and to remove the posters until 16:00 at the latest on the next day. Adhesive stripes will be available at the registration desk. Every poster will briefly be discussed in the poster discussion session, Laboratory and clinical aspects, on Thursday, March 20, 16.15 – 17.15. Maximum discussion time is 10 minutes per poster; printouts of poster (A4) are welcome. Slides are facultative but may not exceed 6 slids per poster. Full abstracts of all posters are available on a USB-stick contained in your congress bag. Also abstracts of some of main talks are available on this USB stick for your disposal. Prizes Brunello Wüthrich Allergy Poster Prize (CHF 1’000) for the best allergy case description. Biotest (Schweiz) AG (CHF 1’000) for the best contribution in clinical immunology SSAI two prices (each CHF 1’000) for the best contribution in experimental immunology and allergy Fondation Ulrich Müller-Gierok, the Allergy Prize 2013 (CHF 10’000) is given for an excellent peer reviewed Swiss publication in clinical Allergology and was awarded at the AIU Grindelwald on January 25, 2014. 40

Registration Desk If you have questions concerning SSAI or WIRM, our registration team will be happy to help you at the registration desk: Opening hours: Tuesday, 18 March 2014

15:00 – 20:00

Wednesday, 19 March 2014

07:30 – 20:00

Thursday,  20 March 2014

07:30 – 20:00

Friday, 21 March 2014

07:30 – 20:00

Saturday, 22 March 2014

07:30 – 18:00

Reduced Ski Rental Bardill Sport, which is located right next to the Jakobshorn Cable Car ­Station in Davos Platz, offers to all SSAI and WIRM participants, speakers, exhibitor staff and registered accompanying persons a reduction of up to 26% for the renting of ski/snowboard equipment. Reduced Ski Tickets The Davos Klosters Mountains offer to all SSAI and WIRM participants, speakers, exhibitor staff and registered accompanying persons a re­ duction of 25% for ski tickets and single tickets for pedestrians. Please note that you will need to show your badge and a voucher at the pay desk of the ski stations. Without badge and voucher you will not be eligible to profit from the reduction. Social Events You will get all information about possible activities in Davos on site at the desk «Transfer and Information Davos Klosters» organized by Davos Services.

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Speakers You are kindly asked to bring your presentation on a memory stick or on your own laptop, 30 minutes before the session starts to the defined room. Speakers with a keynote presentation (program from Apple) need to bring their own laptop. Speaker’s Ready Room The speakers ready room is just to have a quite place to prepare for the talk or work on the presentation. There won’t be the possibility to download it on a server. Wireless network Free WLAN will be provided in the internet corner and in the premises of the Congress Center.  Network:

Davos Congress

Username: wirm Password: wirm2014

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Notices

43

®

bilastinum 20 mg

Das andere Antihistaminikum • schnell und stark wirksam1-4 • gut verträglich5 (Sedation auf Placebo-Niveau)4

6

1 Horak F. et al.; The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflamm Res 2010; 59 (5):391-398. | 2 Church MK.; Comparative inhibition by bilastine and cetirizine of histamine-induced wheal and flare response in humans. Inflamm Res 2011; 60 (12):1107-1112. | 3 Bachert C. et al. Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients. Allergy 2009; 64 (1): 158-165. | 4 Kuna P. et al.; Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study. Clin Exp Allergy 2009; 39 (9): 1338-1347. | 5 Fachinformation, Stand: September 2011. www.swissmedicinfo.ch. BILAXTEN® Antihistaminikum. Z: Bilastin 20 mg Tabl. I: Symptomatische Behandlung der saisonalen allergischen Rhino-Konjunktivitis und Urtikaria. D: Erwachsene und Jugendliche über 12 Jahre: 1 Tbl. 1 x täglich 1 Stunde vor oder 2 Stunden nach der Einnahme von Nahrung oder Fruchtsaft. KI: Überempfindlichkeit auf Wirkstoff oder andere Bestandteile der Tabletten. VM: Co-Medikation mit P-Glycoprotein-Inhibitoren, Patienten mit mässiger Niereninsuffizienz. Bei Patienten mit schwerer Nieren- oder Leberinsuffizienz soll Bilaxten nicht angewendet werden. IA: Nahrung, Grapefruitsaft, Ketokonazol oder Erythromycin, Diltiazem. UAW: Häufig: Kopfschmerzen, Schwindel, Müdigkeit. Gelegentlich: gesteigerter Appetit, Angstgefühl, Schlaflosigkeit, GI-Beschwerden. P: 10, 30, 50 Tbl.