Forskarutbildningskatalog VT09
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# Sjukdomslära * Allmänvetenskap 1126 Klinisk prövning och kritisk värdering av klinisk forskning 2009-03-09--2009-03-20 engelska 1131 Försöksdjursvetenskap 2009-01-26--2009-02-06 engelska 1132 Försöksdjursvetenskap 2009-03-23--2009-04-03 engelska 1220 Problembaserad inlärning i kalcium och fosfolipid signalering 2009-05-04--2009-05-15 engelska 1257 Transcultural Mental Health - screening, intervention and evaluation 2009-03-23--2009-03-27 engelska 1280 Cellulär Signalering 2009-02-09--2009-02-12 engelska 1383 Grundkurs i medicinsk statistik *2009-01-19--2009-02-04 engelska 1383 Grundkurs i medicinsk statistik *2009-03-23--2009-04-22 engelska 1384 Grundkurs i medicinsk statistik *2009-02-16--2009-03-11 svenska 1386 Medicinsk vetenskapsteori och forskningsetik *2009-02-09--2009-02-13 engelska 1386 Medicinsk vetenskapsteori och forskningsetik *2009-05-11--2009-05-15 engelska 1387 Medicinsk vetenskapsteori och forskningsetik *2009-05-04--2009-05-08 svenska 1391 Vetenskapligt skrivande och informationskompetens *2009-03-02--2009-03-13 engelska 1391 Vetenskapligt skrivande och informationskompetens *2009-05-18--2009-05-29 engelska 1392 Vetenskapligt skrivande och informationskompetens *2009-04-14--2009-04-24 svenska 1441 Icke kovalenta interaktioner i proteiner 2009-02-02--2009-03-06 engelska 1447 Introduktionskurs i SAS programmering 2009-04-20--2009-04-24 engelska 1513 Biostatistik II: Logistisk regression för epidemiologer *2009-01-26--2009-01-30 engelska 1544 Kardiovaskulär forskning 1. Vaskulär cellbiologi 2009-05-11--2009-05-16 engelska 1552 Hud, allergi och inflammation 2009-01-26--2009-01-30 engelska 1559 Experimentella tekniker vid studie av metabola och endokrina tillstånd 2009-03-02--2009-03-06 engelska 1577 Epidemiologi I: Introduktion till epidemiologi 2009-05-12--2009-06-09 engelska 1587 Signaltransduktion i hjärnsjukdomar 2009-05-11--2009-05-15 engelska 1620 Oxidativ stress: Sjukdom, Metoder och Koncept 2009-06-01--2009-06-05 engelska 1622 Epidemiologi II. Design av epidemiologiska studier 2009-02-02--2009-02-06 engelska 1626 Cytokiner i inflammation 2009-05-25--2009-06-04 engelska 1635 Basal kurs inom tumörbiologi och onkologi 2009-04-14--2009-04-24 engelska 1658 Från stress till sjukdom 2009-05-04--2009-05-08 engelska 1709 Könshormoner och hjärtkärlsjukdom. Vad vet vi och vad vet vi inte? 2009-03-23--2009-03-27 engelska 1727 Smärtmekanismer: Från molekyler till behandling 2009-06-01--2009-06-05 engelska 1729 Hjärnbarken: Organisation och dynamik 2009-05-04--2009-05-15 engelska 1790 Träning som ett medel att förebygga och behandla metabola sjukdomar 2009-05-25--2009-05-29 engelska 1794 Studiedesign vid klinisk forskning 2009-02-20--2009-04-17 svenska 1816 Datainsamling- och datanalys I: Introd. till kvalitativa metoder 2009-03-03--2009-04-01 engelska 1817 Introduktion till test-teori och analys av kliniska test och enkäter 2009-04-15--2009-05-11 engelska 1818 Intervjuteknik i vård- och omsorgsforskning 2009-01-14--2009-02-12 engelska 1819 Introduktion till multivariat dataanalys *2009-05-13--2009-06-03 engelska 1820 Praktisk kurs i mikroskopbaserad fluorometri i levande celler 2009-05-11--2009-07-31 engelska 1827 Regressionsanalys 2009-02-09--2009-03-06 engelska 1832 Klinisk immunologi i infektionssjukdomar 2009-03-16--2009-03-27 engelska 1876 Resistensartärers funktion vid hälsa och sjukdom 2009-05-25--2009-06-05 engelska 1877 Värd/patogen-interaktioner forskningsseminarieserie 2009-01-14--2009-05-06 engelska 1895 Biostatistik IV: Tillämpad longitudinell dataanalys 2009-04-14--2009-04-22 engelska 1978 Kirurgiska tekniker på råtta och mus 2009-05-25--2009-05-29 engelska 1988 Att skriva en vetenskaplig artikel - och bli publicerad *2009-05-11--2009-05-15 engelska 1992 God datahantering inom epidemiologisk forskning *2009-03-16--2009-03-20 engelska 2000 Avancerat seminarium i Tumörbiologi 2009-01-13--2009-06-16 svenska 2001 Vad är liv? Biologin i framtiden. 2009-01-25--2009-06-10 engelska 2026 Problembaserad översiktskurs av medicinsk statistik *2009-05-11--2009-05-15 engelska 2 of 227
2033 Neuropsykofarmakologi i samband med Affektiva Sjukdomar 2009-03-30--2009-04-03 engelska 2044 Sjukdomslära #2009-05-04--2009-05-15 engelska 2059 Innovation och teknisk hantering 2009-02-01--2009-05-31 engelska 2068 Frontlinjer i ledarskapsforskning 2009-02-24--2009-05-12 engelska 2076 Kvalitativa forskningsmetoder 2009-03-02--2009-03-20 engelska 2084 Människans sjukdomar #2009-01-19--2009-01-30 engelska 2104 Mötet mellan gener och miljö: mänskliga komplexa sjukdomarnas genetik 2009-03-23--2009-03-27 engelska 2111 Introduktion till medicinsk antropologi 2009-02-09--2009-03-20 engelska 2113 Slemhinnemedierad immunitet och infektioner 2009-03-02--2009-03-06 engelska 2126 Fetma: metaboliska och kliniska aspekter 2009-04-20--2009-04-24 engelska 2130 Introduktion till kunskapsanvändning och implementeringsforskning 2009-01-27--2009-03-02 engelska 2131 Forskningsmetoder i ekonomisk utvärdering av folkhälsoarbete 2009-02-09--2009-02-13 engelska 2134 Mer om datahantering och data analys med SPSS-syntax 2009-03-05--2009-03-24 svenska 2137 Medicinsk vetenskapsteori och forskningsetik *2009-03-23--2009-03-27 svenska 2144 Att kommunicera vetenskap i olika sammanhang *2009-04-07--2009-05-20 engelska 2145 Att kommunicera vetenskap i olika sammanhang *2009-01-22--2009-02-19 svenska 2146 Att kommunicera vetenskap i olika sammanhang *2009-04-27--2009-05-29 engelska 2148 Metod och etik i interkulturell forskning med barn 2009-04-20--2009-04-24 engelska 2149 Trombos och hemostas 2009-03-09--2009-03-13 engelska 2150 Multifaktoriella immunmedierade sjukdomar - etiologi och patogenes 2009-03-09--2009-03-13 engelska 2154 Kardiovaskulär Epidemiologi 2009-03-30--2009-04-03 engelska 2155 Demografi och Hälsa 2009-04-20--2009-04-24 engelska 2157 Genetik och epigenetik i stamcellsbiologi 2009-04-20--2009-04-24 engelska 2159 Från forskning till företagande -- koncept inom bioteknologi 2009-03-30--2009-05-28 engelska 2194 Utforska människan i rörelse med datoriserad rörelseanalyssystem 2009-02-05--2009-03-06 engelska 2198 Social kompetens: Presentationsteknik, samarbete och relationsbyggande *2009-01-27--2009-05-26 engelska 2198 Social kompetens: Presentationsteknik, samarbete och relationsbyggande *2009-02-05--2009-06-04 svenska 2201 Klinisk celltransplantation. 2009-03-16--2009-03-20 engelska 2203 Gender-baserad våld och våld mot barn 2009-05-04--2009-05-22 engelska 2204 Datorstöd i kvalitativ analys - NVivo 2009-03-02--2009-05-04 svenska 2205 Socioekonomiska Bestämningsfaktorer för hälsa i utveclingsländer 2009-05-04--2009-06-08 engelska 2206 Akuta infektioner orsakade av Gram-positiva bakterier 2009-06-09--2009-06-15 engelska 2207 Molekylär elektrontomografi för molekylär medicin 2009-01-19--2009-01-30 engelska 2208 Datormodellering av toxikokinetik och cellulära signalvägar 2009-05-11--2009-05-15 engelska 2209 Klinisk och Preklinsk Virologi 2009-05-11--2009-05-18 engelska 2210 Ojämlikhet i hälsa - teori, metod och mått 2009-04-14--2009-04-27 engelska 2211 Grundläggande Laboratoriesäkerhet 2009-03-10--2009-03-20 engelska 2212 Human embryonala stamceller 2009-05-11--2009-05-15 engelska 2213 Demografi, hälsa och samhälle i en åldrande befolkning 2009-03-09--2009-04-06 engelska 2214 Redoxreglering, oxidativ stress och selenproteiner 2009-05-18--2009-05-22 engelska 2215 Praktisk programmering för forskare 2009-02-02--2009-02-20 engelska 2216 Forskningsetik i global och folkhälsa 2009-05-04--2009-05-08 engelska 2217 Kvalitativa Forskingsanalyser 2009-03-23--2009-03-27 engelska 2218 Moderna metoder för DNA-sekvensering 2009-03-23--2009-03-27 engelska 2219 Bioinformatik för cellbiologer 2009-05-25--2009-05-29 engelska 2221 Membranproteiners struktur och funktion 2009-05-04--2009-05-08 engelska 2222 Andning: Bedömnings- och behandlingsmetoder inom ÖNH och logopedi. 2009-03-02--2009-05-08 engelska 2223 Hörsel och hörselskador - med fokus på arbetslivet 2009-03-23--2009-05-15 engelska 2224 Att beforska svåråtkomliga studieområden inom vård och omsorg 2009-03-01--2009-05-01 svenska 3 of 227
2225 Genusperpektiv i vård- och hälsovetenskaplig forskning 2009-03-06--2009-05-26 svenska 2226 Beteendebiologi med fokus på människan 2009-01-26--2009-05-25 svenska 2227 Barn, miljö och hälsa 2009-03-23--2009-03-27 engelska 2228 Genetisk epidemiologi 2009-02-16--2009-02-20 engelska 2229 Introduktion till processning och analys av imagingdata i SPM5 2009-02-16--2009-04-15 engelska 2230 Fenotypning av genetiskt modifierade möss 2009-05-11--2009-05-29 engelska 2231 Från kritisk granskning till evidensbaserad vård 2009-03-17--2009-03-31 svenska 2232 Hjärnans könsskillnader - betydelsen av genetik och epigenetik 2009-05-04--2009-05-11 engelska 2233 Introduktion till kognitiv neurovetenskap 2009-01-28--2009-03-11 engelska 2234 Management och forskning 2009-02-12--2009-05-21 svenska 2235 Presentationsteknik med fokus på innehåll 2009-01-23--2009-05-22 svenska 2236 Vetenskapligt utvärderade interventioner inom suicidprevention 2009-01-12--2009-01-16 engelska 2237 Emotionernas psykobiologi 2009-04-01--2009-05-15 engelska 2238 Systembiologi och omik metoderi 2009-05-25--2009-05-29 engelska 2239 Multi- och megavariat analys för omikforskning 2009-02-09--2009-02-13 engelska 2241 Cancerproteomik 2009-03-09--2009-03-20 engelska 2242 Tillämpad statistisk analys av longitudinella data *2009-03-23--2009-04-24 svenska
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Title: Clinical trials and critical evaluation of clinical research Course number: 1126 Credit points: 3.0 Date: 2009-03-09 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Learning outcomes: How to plan and concuct a study. How to analyze and present results. How to critically evaluate published research. Contents of the course: How a study program is developed for a new drug or other treatment. How to plan a study, i. e. how to define study objectives, how to minimize confounding, choices of --end points-- and methods to document treatment effects, how to choose comparative interventions and use placebos, statistical aspects (--power-- calculations, etc), patient selection, randomization and stratification, drop-outs, effect and side-effect measurements, ethical review (and ethical considerations in clinical research), scientific misconduct (prevention and handling of allegations), etc. Advantages and disadvantages with multi-center studies will be discussed. How to conduct a study -- e. g. Patient recruitment, collection and management of data monitoring (GCP procedures). How to analyze and present results. i. e. data quality control, statistical evaluation (hypothesis testing vs. hypothesis generating analyses, --intention-to-treat-- vs. --on treatment-- analyses etc.) data presentation. How to critically evaluate published research. Statistical issues will be important throughout the course. Scientific value vs. marketing incentives will be discussed. Problems related to special fields, such as quality of life studies, -surrogate end points--, economic --end points--, survival studies vs. mechanistic or surrogate --end point-studies will be discussed. Examples will be taken from cardiology, gastroenterology, psychiatry and other disciplines. Type of teaching: Lectures, group work and some individual work. Examination: Group work presentations and discussions. Group work presentations Compulsory parts: Number of students: 15 - 30 Selection of students: PhD students engaged in clinical research (any speciality), preferably, with some research experience. More detailed information: The course is given at Karolinska University Hospital, Solna. The schedule of the previous course can be sent on demand. - 30 Course responsible Paul Hjemdahl Clin Pharmacology Unit, L7:05, Karolinska University Hospital, Solna Stockholm +46 8 517 752 93 5 of 227
[email protected] Clin Pharmacology Unit Department of Medicine, Solna Course contact Lillemor Melander Clin Pharm Unit, L7:05, Karolinska University Hospital 17176 Stockholm +46 8 517 752 92
[email protected] Clin Pharm Uni Department of Medicine, Solna
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Title: Laboratory Animal Science Course number: 1131 Credit points: 4.5 Date: 2009-01-26 - 2009-02-06 Språk: english Level: Forskarnivå Responsible department: University Administration Learning outcomes: After the course, the student will possess the following qualifications 1.Humane use of animals. Know how to handle laboratory animals in a humane manner. 2.The Swedish law and required permissions. Knows the legal requirements in Sweden for conducting animal experiments. Knows where and how to apply for required permissions. Capable to translate legal and ethical requirements into the practical design of new animal experiments. 3.Housing and breeding of laboratory animals. Can discuss laboratory environments vs. animal quality of life and hygienic needs. Handles both wild type and genetically modified animals effectively and safely. Can explain how animal nutrition may impact on research results. 4.Laboratory animal diseases and health risks. Knows microbes and parasites that commonly infect laboratory animals. Can explain how these may impact on experimental results. Can demonstrate how common health risks and preventable adverse events in laboratory animals can be minimised. 5.Practice. Can handle laboratory animals appropriately with respect to species differences. Can identify and apply appropriate methods for experimental treatment, such as administration of analgesia or anaesthesia, surgery including perioperative care, and euthanasia. 6.Alternative methods, species selection, and power calculations. Can systematically explore and evaluate animal free research methods. Can appropriately select animal species, where needed for new research activities. Can calculate the statistical power of a study and minimal sample size to minimise the use of animals. Complies with good laboratory practice (GLP) requirements where needed. Contents of the course: The course contents are in accordance with recommendations from the Federation of European Laboratory Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animal science, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies and other health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies, alternatives to animal use, good laboratory practice, microbiology disease, preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint, injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will prepare an experimental protocol and analyse a scientific paper. A written examination is included. Type of teaching: Lectures, group assignments and laboratory practice. Examination: Written exam and group assignments Compulsory parts: All practical sessions, all group works and some of the lectures are cumpulsory. Missed parts can be completed after agreement with Veterinary Resources. Number of students: 30 - 60 Selection of students: Priority will be given to applicants who can shortly and concisely (max 250 words) show in their application an 7 of 227
urgent need to begin their independent work with laboratory animal experiments. All applications via www.ki.se before November 15, 2008. More detailed information: The course contents are in accordance with recommendations from the Federation of European Laboratory Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animal science, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies and other health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies, alternatives to animal use, good laboratory practice, microbiology disease, preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint, injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will analyse a scientific paper (which will be available one week before the course starts) and prepare an experimental protocol that should be presented as an ethical application. A written examination is included on the last day of the course. Key speakers include Professors Vera Baumans, Torbjörn Tännsjö, René Remie, Jann Hau. Other teachers include university veterinarians and specialist lecturers at KI, as well as representatives from the pharmaceutical industry and an animal protection organisation. - 60 Course responsible Sigrid-Lisa Olsson Nobels väg 5 17177 Stockholm +46 8 524 861 28
[email protected] Dept of Research and Postgraduate Education University Administration Course contact Juha Halonen Nobels väg 5 Solna +46852486529
[email protected] FFU, Veterinary Resources University Administration
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Title: Laboratory Animal Science Course number: 1132 Credit points: 4.5 Date: 2009-03-23 - 2009-04-03 Språk: english Level: Forskarnivå Responsible department: University Administration Learning outcomes: After the course, the student will possess the following qualifications 1.Humane use of animals. Know how to handle laboratory animals in a humane manner. 2.The Swedish law and required permissions. Knows the legal requirements in Sweden for conducting animal experiments. Knows where and how to apply for required permissions. Capable to translate legal and ethical requirements into the practical design of new animal experiments. 3.Housing and breeding of laboratory animals. Can discuss laboratory environments vs. animal quality of life and hygienic needs. Handles both wild type and genetically modified animals effectively and safely. Can explain how animal nutrition may impact on research results. 4.Laboratory animal diseases and health risks. Knows microbes and parasites that commonly infect laboratory animals. Can explain how these may impact on experimental results. Can demonstrate how common health risks and preventable adverse events in laboratory animals can be minimised. 5.Practice. Can handle laboratory animals appropriately with respect to species differences. Can identify and apply appropriate methods for experimental treatment, such as administration of analgesia or anaesthesia, surgery including perioperative care, and euthanasia. 6.Alternative methods, species selection, and power calculations. Can systematically explore and evaluate animal free research methods. Can appropriately select animal species, where needed for new research activities. Can calculate the statistical power of a study and minimal sample size to minimise the use of animals. Complies with good laboratory practice (GLP) requirements where needed. Contents of the course: The course contents are in accordance with recommendations from the Federation of European Laboratory Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animal science, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies and other health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies, alternatives to animal use, good laboratory practice, microbiology disease, preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint, injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will prepare an experimental protocol and analyse a scientific paper. A written examination is included. Type of teaching: Lectures, group assignments and laboratory practice. Examination: Written exam and group assignments Compulsory parts: All practical sessions, all group works and some of the lectures are cumpulsory. Missed parts can be completed after agreement with Veterinary Resources. Number of students: 30 - 60 Selection of students: Priority will be given to applicants who can shortly and concisely (max 250 words) show in their application an 9 of 227
urgent need to begin their independent work with laboratory animal experiments. All applications via www.ki.se before November 15, 2008. More detailed information: The course contents are in accordance with recommendations from the Federation of European Laboratory Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animal science, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies and other health hazards, gnotobiology, nutrition, animal welfare, environment and experimental procedures, transgenic technologies, alternatives to animal use, good laboratory practice, microbiology disease, preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection. Demonstrations/laboratory sessions (in smaller groups): Techniques for handling and restraint, injection, sampling and anaesthesia (rabbit, rat, mouse). Additionally, students will analyse a scientific paper (which will be available one week before the course starts) and prepare an experimental protocol that should be presented as an ethical application. A written examination is included on the last day of the course. - 60 Course responsible Sigrid-Lisa Olsson Nobels väg 5 17177 Stockholm +46 8 524 861 28
[email protected] Dept of Research and Postgraduate Education University Administration Course contact Juha Halonen Nobels väg 5 Solna +46852486529
[email protected] FFU, Veterinary Resources University Administration
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Title: Problem-Based Learning in Calcium and Phospholipid Signaling Course number: 1220 Credit points: 3.0 Date: 2009-05-04 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Science and Education, Södersjukhuset Included in postgraduate course programme: Developmental Biology and Cellular Signaling Learning outcomes: At the end of the course the participants will understand molecular proceses involved in maintaining intracellular Ca2+ homeostasis and their roles in the generation and decoding of Ca2+ and phospholipids mediated signals. They will be able to analyse and interpret existing literatures critically and ask new question in this area of research. They will understand the principles of common methods including those of microscope based fluorometry in living cells, confocal and multiphoton imaging and electrophysiology. Participants will receive practical training in the methods of measurement of intracellular free Ca2+ concentration and confocal microscopy. After completion of the course, participants will be able to come up with new ideas, generate new hypotheses and identify approaches to test them by using different methods. Contents of the course: 1. Phospholipase C and inositol 1,4,5 trisphosphate mediated signaling. 2. Identity and roles of molecular players involved in Ca2+ and phospholipid mediated signaling. 3. Preparation of Ca2+ buffers. 4. methods used in the study of calcium and phospholipid signaling including fluorescent techniques, electrphysiology and imaging techniques. 5. regulation of ion channels involved in Ca2+ signaling including voltage sensitive channels, transient receptor potential channels, store-operated channels and intracellular channels. 6. roles of Ca2+ and phospholipid mediated signaling in cellular processes including in secretion and apoptosis. 7. Mechanism of generation and decoding of Ca2+ signals. 8. spatial and temporal aspects of Ca2+ signaling. 9. how to pick research problems in the areas of Ca2+ and phospholipid signaling and how to approach them. Type of teaching: This course will follow the classical seven steps approach of problem-based-learning (PBL). Emphasis will be on self-directed learning through problem-solving in small groups rather than on cathedral lectures. However, generous small group interactive lectures by resource personnel and selected practical sessions will be provided. Participants will work on five given problems, in groups of about nine participants, under supervision of two trained facilitators. Participants will be provided with an outline of the objectives, areas expected to cover, and selected learning materials. In practical sessions, participants will observe the use of microfluorometry and confocal microscopy and confocal microscopy for measurement of intracellular free Ca2+. Examination: 1. Observation by the facilitators of the participants role in the learning processes during group activitites. 2. Presentation of assignment in group seminar. 3. Individual written reports Compulsory parts: Submission of written report is essential for obtaining a pass grade Number of students: 10 - 20 Selection of students: The selection is based on the relevance of the course content for the research project and a personal motivation letter. Registered PhD students are given priority. Each year we receive some participants from outside Sweden 11 of 227
too. More detailed information: Laboratory demonstrations are organized during the 2nd week of the course. - 20 Course responsible Shahidul Islam Research Center 3rd Floor, 11883 Stockholm 8-6163950; 0702593446
[email protected] Department of Clinical Sciences and Education Department of Clinical Science and Education, Södersjukhuset Course contact Shahidul Islam Research Center 3rd Floor, 11883 Stockholm 8-6163950; 0702593446
[email protected] Department of Clinical Sciences and Education Department of Clinical Science and Education, Södersjukhuset
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Title: Transcultural Mental Health - screening, intervention and evaluation Course number: 1257 Credit points: 3.0 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: World Health Learning outcomes: At the end of the module students will be able to: - identify transcultural mental health key concepts - discuss transcultural research methods, some basic and relevant research obstacles, ethical issues, and factors determining the variations in mental health among different immigrant groups - assess methods for transcultural mental health and mental health promotions strategies - reflect about own values and norms in research questions, methods, and outcomes and evalutation Contents of the course: Review relevant research literature. Some basic and relevant research obstacles, paradigms, ethical issues and questions in transcultural mental health research. An overview of different qualitative research methods, validity, trustworthiness, tranferability and implications of contextualized findings, an explorative case. Physiological, psychosocial and diagnostic measurement of mental health assessment among refugee groups, prospective design. How to perform a survey based on register: Migration, access to employment and mental health Circumstances of and treatment and other services provided for patients with mental illness in a multicultural area, skills in using traditional and internet tools in collecting data Type of teaching: The course will consist of 1 week, fulltime, and 1 week of reading material before the start. Leaning activities include lectures, group work, video-conference lecture and discussion, individual assignments and and interactive seminars Examination: Individual project/thesis description, title and study area; study design and methods. Oral presentation of group work Compulsory parts: It is compulsory to attend all the lectures. Absence will be compensated for by extra individual assignments provided by the course organizers Number of students: 10 - 20 Selection of students: The students will be selected by motivation and time from registration as PhD student More detailed information: Given at KI-Campus, full-time course - 20 Course responsible Solvig Ekblad 13 of 227
Norrbacka Socialmedicin 171 Stockholm 070-517 50 65
[email protected] Department of Public Health Sciences Course contact Anna-Clara Hollander Norrbacka Socialmedicin 171 Stockholm 08-7373799
[email protected] Department of Public Health Sciences
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Title: Cellular Signalling Course number: 1280 Credit points: 1.5 Date: 2009-02-09 - 2009-02-12 Språk: english Level: Forskarnivå Responsible department: Department of Laboratory Medicine Included in postgraduate course programme: Developmental Biology and Cellular Signaling Learning outcomes: The course aim is to give a broad view of various signalling pathways and identify common themes on proteinprotein and protein-lipid interactions. The students shall learn on how signal transduction occurs through a highly regulated cascade of events in side cells. The student should identify and reflect the knowledge gained with the benefit of own research. After the course, the student: - should have basic theoretical knowledge in cellular signalling field. - should receive knowledge on modern methods and techniques, which is commonly applied in the research field. - should give an oral presentation of a short scientific article within a specific research field, which critically evaluated. - should be able to use the knowledge to his/her own research project. Contents of the course: The course brings up current aspects in cellular signalling and the updated developments in understanding the function of signalling pathways in various cell model systems. The course will cover major aspects of protein and lipid kinases, heterotrimeric G-proteins, small GTPases, cytokine and growth hormone receptors, secondary messengers, transcriptional regulation and signal transduction in cell specific responses of stimuli. In the context of the functional genomic era, the course will cover the molecular basis of certain human diseases related to the abrogation of signalling pathways. Type of teaching: Lectures, presentations and group discussions. Examination: Oral Presentation Compulsory parts: All lectures are compulsory, missing lectures must be compensated by written résumé Number of students: 20 - 30 Selection of students: The students will be selected by motivation and time from registration as PhD student. More detailed information: All invited lectures are from KI and other universities in Sweden and/or Scandinavien, occasionally invited an speaker from abroad (EU, North America or Japan) giving a lecture. - 30
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Title: Basic Course in Medical Statistics Course number: 1383 Credit points: 3.0 Date: 2009-01-19 - 2009-02-04 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: The course participants shall after the course be able to perform basic summaries, analyses and presentation of their data, as well as have enhanced their ability to recognise, understand and critically view the statistics being presented in medical articles. Contents of the course: The course is an introduction to basic statistical principles and how statistics play a part in medical research. Concepts being treated are hypothesis, type I error, type II error, estimate, measurement of dispersion, regression analysis, inference making and how to present the results. Type of teaching: The course will consist of three scheduled half or whole days per week for three weeks. Lectures will be mixed with seminars, where the course participants have group discussions, and manual excercises. The rest of the time will be spent working on computer based homework and reading the course literature. Examination: Course requirements: - Correct answers on the computer based exercises. - Active participation in the manual calculations. - Active participation in the seminars. Compulsory parts: Attendance is mandatory for the manual exercises and the seminars. If the student is absent, he or she can compenste the absence by handing in written answers to questions concerning the compulsory moments. Number of students: 30 - 40 Selection of students: Registration date as a postgraduate student More detailed information: 19 - 21/1, 26 - 28/1, 2 - 4/2 - 40 Course responsible Magnus Backheden Berzelius väg 3 Stockholm +46852487121
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt Berzelius väg 3 Stockholm +46852487118 16 of 227
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Basic Course in Medical Statistics Course number: 1383 Credit points: 3.0 Date: 2009-03-23 - 2009-04-22 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: The course participants shall after the course be able to perform basic summaries, analyses and presentation of their data, as well as have enhanced their ability to recognise, understand and critically view the statistics being presented in medical articles. Contents of the course: The course is an introduction to basic statistical principles and how statistics play a part in medical research. Concepts being treated are hypothesis, type I error, type II error, estimate, measurement of dispersion, regression analysis, inference making and how to present the results. Type of teaching: The course will consist of three scheduled half or whole days per week for three weeks. Lectures will be mixed with seminars, where the course participants have group discussions, and manual excercises. The rest of the time will be spent working on computer based homework and reading the course literature. Examination: Course requirements: - Correct answers on the computer based exercises. - Active participation in the manual calculations. - Active participation in the seminars. Compulsory parts: Attendance is mandatory for the manual exercises and the seminars. If the student is absent, he or she can compenste the absence by handing in written answers to questions concerning the compulsory moments. Number of students: 30 - 40 Selection of students: Registration date as a postgraduate student More detailed information: 23 - 25/3, 30/3 - 1/4, 20 - 22/4 - 40 Course responsible Magnus Backheden Berzelius väg 3 Stockholm +46852487121
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt Berzelius väg 3 Stockholm +46852487118 18 of 227
[email protected] Department of Learning, Informatics, Management and Ethics
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Titel: Grundkurs i medicinsk statistik * Kursnummer: 1384 Antal högskolepoäng: 3.0 Datum: 2009-02-16 - 2009-03-11 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för lärande, informatik, management och etik Kursens lärandemål: Efter kursen ska kursdeltagaren själv kunna göra enklare sammanställningar, analyser och presentationer av sina data, samt ha utvecklat sin förmåga att känna igen, förstå och kritiskt granska den statistik som är presenterad i medicinska tidskrifter. Kursens innehåll: Introduktion av grundläggande statistiska principer och statistikens roll i medicinsk forskning. Hypotesprövning, fel av typ I och II, estimat, spridningsmått, konfidensintervall, regressionsanalys, konklusion och presentation av resultat behandlas. Arbetsformer: Undervisningen består av tre schemalagda halv-eller heldagar per vecka under tre veckor. Föreläsningar varvas med seminarier, där kursdeltagarna får diskutera i grupp, samt manuella räkneövningar. Övrig tid ägnas åt arbete med datorbaserade hemuppgifter samt inläsning av kurslitteraturen. Examination: Krav för att godkännas på kursen: - Godkända datorövningar (hemuppgifter). - Aktivt deltagande i de manuella räkneövningarna. - Aktivt deltagande i seminarierna. Obligatoriska moment: Obligatorisk närvaro gäller för de manuella räkneövningarna samt seminarierna. Om doktoranden är frånvarande vid något sådant moment skall han eller hon skriftligen svara på frågor som hör till respektive moment. Antal studenter: 30 - 40 Urval av studenter: Registreringsdatum till forskarutbildningen Ytterligare information: 16 - 18/2, 2 - 4/3, 9 - 11/3 Ansvarig för kurstillfälle Magnus Backheden Berzelius väg 3 Stockholm +46852487121
[email protected] Institutionen för lärande, informatik, management och etik Kontaktperson för kurstillfälle Margareta Krook-Brandt Berzelius väg 3 Stockholm 20 of 227
+46852487118
[email protected] Institutionen för lärande, informatik, management och etik
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Title: Philosophy of science and research ethics Course number: 1386 Credit points: 1.5 Date: 2009-02-09 - 2009-02-13 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: The PhD students is supposed to be capable to present his/her own research within the framework of philosophy of science and research ethics and able to debate it in relation to scientific norms on what is understood as normal science, scientific argumentation and good research practice. The PhD student is also supposed to question what is understood as a scientific fact, acknowledge the difference between knowing how and knowing that, how science develop, the current view on fallibilism as well as the historical development of informed consent and the Helsinki Declarations, the research ethics committees and their ethical and legal framework. Contents of the course: The subsequent headings illustrate the course contents: What is a scientific paradigm? What is a scientific fact? Is observation a theory free activity? Where does the hypothesis come from? How does scientific argumentation look like? (why is the chain metaphor debatable?) Is the scientific enterprise value-free? Do patients and research persons have moral duties to participate in clinical research? What are the conditions for human beings and animals to participate in medical research? How do we justify the use of animals for the benefit of mankind? Type of teaching: Introducing lectures, group work and general discussions. Examination: - Attendance is mandatory for the group work and general discussions. - The PhD students write a short informal essay on a scientific or research ethical theme related to their own research. Compulsory parts: If the student is absent, he or she can compenste by handling in written answers concerning the cases that have been discussed. Number of students: 30 - 40 Selection of students: Registration date as a postgraduate student More detailed information: - 40 Course responsible Niels Lynöe Berzelius väg 3 +46852486058
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt 22 of 227
Berzelius väg 3 Stockholm +46852487118
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Philosophy of science and research ethics Course number: 1386 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: The PhD students is supposed to be capable to present his/her own research within the framework of philosophy of science and research ethics and able to debate it in relation to scientific norms on what is understood as normal science, scientific argumentation and good research practice. The PhD student is also supposed to question what is understood as a scientific fact, acknowledge the difference between knowing how and knowing that, how science develop, the current view on fallibilism as well as the historical development of informed consent and the Helsinki Declarations, the research ethics committees and their ethical and legal framework. Contents of the course: The subsequent headings illustrate the course contents: What is a scientific paradigm? What is a scientific fact? Is observation a theory free activity? Where does the hypothesis come from? How does scientific argumentation look like? (why is the chain metaphor debatable?) Is the scientific enterprise value-free? Do patients and research persons have moral duties to participate in clinical research? What are the conditions for human beings and animals to participate in medical research? How do we justify the use of animals for the benefit of mankind? Type of teaching: Introducing lectures, group work and general discussions. Examination: - Attendance is mandatory for the group work and general discussions. - The PhD students write a short informal essay on a scientific or research ethical theme related to their own research. Compulsory parts: If the student is absent, he or she can compenste by handling in written answers concerning the cases that have been discussed. Number of students: 30 - 40 Selection of students: Registration date as a postgraduate student More detailed information: - 40 Course responsible Niels Lynöe Berzelius väg 3 +46852486058
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt 24 of 227
Berzelius väg 3 Stockholm +46852487118
[email protected] Department of Learning, Informatics, Management and Ethics
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Titel: Medicinsk vetenskapsteori och forskningsetik * Kursnummer: 1387 Antal högskolepoäng: 1.5 Datum: 2009-05-04 - 2009-05-08 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för lärande, informatik, management och etik Kursens lärandemål: Ska kunna presentera och sätta sin egen forskning i ett vetenskapsteoretisk och forskningsetisk sammanhang och kunna problematisera den i relation till vetenskapliga normer för vad som är normalvetenskap, vetenskaplig argumentation och god forskningssed. Ska också kunna problematisera vad som förstås vid ett vetenskapligt faktum, veta skillnaden mellan vetande och kunnande, hur vetenskapen kan utveckla sig, synen på falibilism samt den historiska utvecklingen av det informerade samtycket och Helsingforsdeklarationerna, etikprövningsnämndernas verksamhet och bedömningsgrunder. Kursens innehåll: Följande rubriker illustrerar innehållet i kursen: Vad förstås vid ett vetenskapligt paradigm? Vad förstås vid ett vetenskapligt faktum? Är observation en teorifri aktivitet? Varifrån kommer hypoteser? Hur ser vetenskaplig argumentation ut? Är vetenskaplig forskning värderingsfri? Har försökspersoner en moralisk skyldighet att ställa upp i klinisk forskning? Vad är villkoren för att vi får bedriva forskning med människor och djur? Hur kan vi rättfärdiga användningen av djur i medicinsk forskning med avsikten att göra gott och inte skada människor? Arbetsformer: Introducerande föreläsningar, grupparbeten och plenumdiskussioner. Examination: Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt eget forskningsprojekt. Gruppdiskussionerna och plenumdiskussionerna är obligatoriska. Obligatoriska moment: Gruppdiskussionerna och plenumdiskussionerna är obligatoriska. Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats. Antal studenter: 30 - 40 Urval av studenter: Registreringsdatum till forskarutbildningen Ytterligare information: Ansvarig för kurstillfälle Niels Lynöe Berzelius väg 3 +46852486058
[email protected] Institutionen för lärande, informatik, management och etik Kontaktperson för kurstillfälle Margareta Krook-Brandt Berzelius väg 3 Stockholm 26 of 227
+46852487118
[email protected] Institutionen för lärande, informatik, management och etik
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Title: Writing science and information literacy Course number: 1391 Credit points: 3.0 Date: 2009-03-02 - 2009-03-13 Språk: english Level: Forskarnivå Responsible department: Karolinska Institutet University Library Learning outcomes: After the course, you should: - be able to organize, write and revise a research report based on own data - know how applications are evaluated and have some idea about what makes applications successful - have practiced writing about research for a general audience - be able to recognize and correct common structural and stylistic writing weaknesses - be aware of ethical considerations in connection with the writing process - know how to submit a paper and understand the scientific communication system - be able to analyze scientific problems from an information needs perspective - be able to apply the principles of medical information retrieval - know about medical sciences databases and other information resources - be able to retrieve, evaluate and cite the medical sciences literature - understand what Open Access implies Contents of the course: Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Getting started with reference management -- Endnote, Tips and tricks with Word, Literature evaluation tools for the medical sciences, Open Access Type of teaching: Individual writing and rewriting, lectures, working in pairs and groups, web-based teaching, demonstrations, computer exercises and individual study Examination: Writing a grant application with popular science summary and rewriting (including references) based on peer and teacher feedback Compulsory parts: The course writing assignment is obligatory and has to be submitted about 10 days BEFORE course start. All scheduled teaching is complusory (except where clearly stated otherwise). Absence can be compensated for by reading and individual work after consultation with course leaders. Number of students: 30 - 34 Selection of students: Primarily on registration date as postgraduate student More detailed information: - 34 Course responsible David Herron Berzelius väg 7 B Solna +46 8 524 84113 28 of 227
[email protected] Karolinska Institutet University Library
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Title: Writing science and information literacy Course number: 1391 Credit points: 3.0 Date: 2009-05-18 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Karolinska Institutet University Library Learning outcomes: After the course, you should: - be able to organize, write and revise a research report based on own data - know how applications are evaluated and have some idea about what makes applications successful - have practiced writing about research for a general audience - be able to recognize and correct common structural and stylistic writing weaknesses - be aware of ethical considerations in connection with the writing process - know how to submit a paper and understand the scientific communication system - be able to analyze scientific problems from an information needs perspective - be able to apply the principles of medical information retrieval - know about medical sciences databases and other information resources - be able to retrieve, evaluate and cite the medical sciences literature - understand what Open Access implies Contents of the course: Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Getting started with reference management -- Endnote, Tips and tricks with Word, Literature evaluation tools for the medical sciences, Open Access Type of teaching: Individual writing and rewriting, lectures, working in pairs and groups, web-based teaching, demonstrations, computer exercises and individual study Examination: Writing a grant application with popular science summary and rewriting (including references) based on peer and teacher feedback Compulsory parts: The course writing assignment is obligatory and has to be submitted about 10 days BEFORE course start. All scheduled teaching is complusory (except where clearly stated otherwise). Absence can be compensated for by reading and individual work after consultation with course leaders. Number of students: 30 - 34 Selection of students: Primarily on registration date as postgraduate student More detailed information: - 34 Course responsible David Herron Berzelius väg 7 B Solna +46 8 524 84113 30 of 227
[email protected] Karolinska Institutet University Library
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Titel: Vetenskapligt skrivande och informationskompetens * Kursnummer: 1392 Antal högskolepoäng: 3.0 Datum: 2009-04-14 - 2009-04-24 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Karolinska Institutet Universitetsbibliotek Kursens lärandemål: Efter kursen ska du: - kunna organisera, skriva och revidera en forskningsrapport baserad på egna data - känna till hur ansökningar utvärderas och några av framgångsfaktorerna - ha prövat att skriva populärvetenskapligt - känna igen och kunna korrigera de vanligaste strukturella och stilistiska svagheterna i text - vara medveten om etiska överväganden vid vetenskapligt skrivande - känna till ansökningsförfarandet och det vetenskapliga publiceringssystemet - kunna analysera vetenskapliga frågeställningar ur ett informationsperspektiv - kunna tillämpa principer för medicinsk databassökning - känna till ett antal biomedicinska databaser och andra informationsresurser - kunna söka, värdera och citera medicinsk vetenskaplig information - förstå vad Open Access innebär Kursens innehåll: Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structure and style, Ethical issues in writing, Publication process, Principer för medicinsk databassökning, Introduktion till referenshantering -- Endnote, Tips och råd i Word, Evalueringsverktyg för medicinsk vetenskap, Open Access. OBS! Vissa delar av kursen ges på engelska (listade på engelska ovan). Arbetsformer: Individuella skrivuppgifter och revision, föreläsningar, par- och grupparbeten, webbaserat lärande, demonstrationer, datorövningar och individuella studier. Examination: Skrivande av en anslagsansökan med populärvetenskaplig sammanfattning samt bearbetning (med referenser) baserat på "peer"- och lärarkommentarer. Obligatoriska moment: Skrivuppgiften (nedan) är obligatorisk och måste inlämnas cirka 10 dagar FÖRE kursens början. Antal studenter: 30 - 34 Urval av studenter: Primärt baserad på registreringsdatum som doktorand Ytterligare information: Ansvarig för kurstillfälle David Herron Berzelius väg 7 B Solna +46 8 524 84113
[email protected] 32 of 227
Karolinska Institutet Universitetsbibliotek
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Title: Non-covalent interactions in proteins Course number: 1441 Credit points: 7.5 Date: 2009-02-02 - 2009-03-06 Språk: english Level: Forskarnivå Responsible department: Department of Biosciences and Nutrition Included in postgraduate course programme: Nanobiology and Biological Physics Learning outcomes: After the course, the students should have reached correct understanding of the physical basis of the different types of non-covalent interactions and their role in functional properties of protein. Furthermore, the students should have acquired to capacity to correctly devise an experimental strategy within the subject and to correctly interpreting experimental results relevant to the topic. Contents of the course: Van der Waals interactions Hydrogen bonds Hydrophobic interactions Packing density of proteins, molecular volume Debye - Hückel theory Desolvation energy, Born theory Calculation of the electrostatic interactions in proteins Ionisation equilibria Protonation/deprotonation equilibria in proteins Application of the theory of electrostatic interactions Denatured proteins pH stability of proteins Thermal denaturation Interrelation between non-covalent interactions Thermodynamics of proteins, experiments, interpretations The analysis of non-covalent interactions for drug design Type of teaching: Lectures by invited speakers, home works, seminars and roundtable discussions Examination: Written exam: three tasks should be solved, solutions should be defended. Compulsory parts: Number of students: 5 - 20 Selection of students: Priority will be given to students working on projects that require knowledge in biophysics or physical chemistry. Basic knowledge in chemistry or physics from university is required. Applications with inadequately expressed motivation are not considered. More detailed information: Invited speakers: Prof. Jelesarov, University of Zurich, General topic on thermodynamics of proteins, experiments, interpretations. Prof. Villoutreix, University Paris Diderot, Key concepts and applications of in silico screening and drug 34 of 227
design. - 20 Course responsible Andrey Karshikoff Hälsovägen 7, 14157 Huddinge 08 6089180
[email protected] Department of Biosciences and Nutrition Course contact Andrey Karshikoff Hälsovägen 7, 14157 Huddinge 08 6089180
[email protected] Department of Biosciences and Nutrition
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Title: Introductory course in SAS programming Course number: 1447 Credit points: 1.5 Date: 2009-04-20 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: - apply the SAS system when importing and exporting data. - manipulate data using SAS labels and formats. - manipulate data using SAS functions and programming statements. - perform descriptive statistics using adequate SAS procedures. - describe how to use the SAS help manual (SAS OnlineDoc). Contents of the course: The course is designed to give fundamental insights in the SAS system and basic skills in the SAS programming language. The course embraces commands for definition, description, modification, selection and analysing of data, and covers: - Introduction to the SAS Windows - SAS data sets, creating, importing and exporting data - Data handling, programming statements and SAS functions - SAS procedures for descriptive statistics Type of teaching: Full-time in supervised computer lab with a mixture of interactive lectures and excercises. Every morning a quiz, recapitulating the previous days' lectures. Examination: o pass the course, the student has to show that the learning outcomes have been achieved. The course will end with an examination consisting of both an individually written and individually computerized exam where the covered commands are used. Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Compulsory parts: Only the examination is compulsory. Number of students: 12 - 24 Selection of students: 1. Registered postgraduate students from KI 2. Registered postgraduate students from outside KI 3. Others Within each category, students will be prioritised according to the relevance of the course content for their research. Basic computer skills are required. To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and 36 of 227
previous courses taken. More detailed information: - 24 Course responsible Jette Möller Norrbacka, 5:th floor 171 Stockholm 08-737 38 64
[email protected] Department of Public Health Sciences Course contact Jette Möller Norrbacka, 5:th floor 171 Stockholm 08-737 38 64
[email protected] Department of Public Health Sciences
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Title: Biostatistics II: Logistic regression for epidemiologists Course number: 1513 Credit points: 1.5 Date: 2009-01-26 - 2009-01-30 Språk: english Level: Forskarnivå Responsible department: Department of Medical Epidemiology and Biostatistics Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: - choose a suitable regression model for assessing a specific research hypothesis using data collected from an epidemiological study, fit the model using standard statistical software, evaluate the fit of the model, and interpret the results. - explain the concept of confounding in epidemiological studies and demonstrate how to controll/adjust for confounding using statistical models. - apply and interpret appropriate statistical models for studying effect modification. - critically evaluate the methodological aspects (design and analysis) of a scientific article reporting an epidemiological study. Learning outcomes are classified according to Bloom¿s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Contents of the course: This course focuses on the application of logistic regression in the analysis of epidemiological studies. Topics covered include a brief introduction to categorical data analysis, simple logistic regression, interpretation of parameters for continuous and categorical predictors, multivariate logistic regression, confounding and interaction, model fitting and model diagnostics, conditional logistic regression, multinomial and ordinal logistic regression. Type of teaching: Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software, exercises not requiring statistical software, group discussions, literature review. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. The course grade is based solely on a written examination. The focus of the exam will be on understanding concepts and their application to analysis of epidemiological studies rather than mathematical detail. The course examination will be held within one week of the final day of the course. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms then a third examination will be scheduled within 12 months of the final day of the course. Compulsory parts: Only the examination is compulsory. Number of students: 12 - 25 Selection of students: 1.Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 38 of 227
3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" and "Biostatistics I: Introduction for epidemiologists" or corresponding courses. To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: More information will be on our webpagehttp://ki.se/ki/jsp/polopoly.jsp?d=14380&a=40967&l=en - 25 Course responsible Rino Bellocco Nobelsväg 12 A 17177 Stockholm +46852486183
[email protected] Department of Medical Epidemiology and Biostatistics Course contact Marie Dokken Box 281, 171 77 Stockholm Stockholm +46852482341
[email protected] Department of Medical Epidemiology and Biostatistics
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Title: Cardiovascular Research 1.Vascular Cell Biology Course number: 1544 Credit points: 1.5 Date: 2009-05-11 - 2009-05-16 Språk: english Level: Forskarnivå Responsible department: Department of Molecular Medicine and Surgery Included in postgraduate course programme: Cardiovascular research Learning outcomes: After a successfully completed course, the student should be able to 1) Account for the various cell types and extracellular matrix components in the vascular wall, 2) understand the interaction between the different cell types and matrix components and the effect by/on the systemic circulation and 3) be able to identify and understand the principles for both invitro and invivo methods used to study the vascular wall. Contents of the course: The course provides an introduction to and the methods used to study the basic cell types and extracellular matrix components present in the vascular wall, with special emphasis on smooth muscle cells and endothelial cells. Focus will also be put on the basic cell biological processes (activation, migration, proliferation, apoptosis) involved in the main vascular pathologies such as atherosclerosis, hypertension, diabetes and aneurysm development. Vascular development and remodelling (angiogenesis, arteriogenesis) will be discussed. Cell-cell and cell-matrix interaction and signaling will be addressed. We will also take into account the differences in function with regard to the arterial, venous and lymphatic systems. Type of teaching: Lectures, project presentation, group seminars and study visit to a vascular laboratory. Examination: The examination will consist of project presentation by the individual students, presentation from the visit to the vascular laboratory and discuss groupwise 2-3 questions that will be distributed to the students beforehand. Compulsory parts: Group work and examination. If the student does not take part in the above, he/she will be asked to visit a vascular laboratory and submit a report. A written examination will be required for those students who do not attend the Course examination. Number of students: 8 - 22 Selection of students: Priority will be given to registered Ph.D. students with projects within the field of the course and motivation given in the application. More detailed information: The Course will be held at the Karolinska University Hospital Solna with course leaders working as clinicians with a strong interest in basic science. We will try to create a translational environment with lecturers and students from both preclinical and clinical departments. - 22 Course responsible Joy Roy CMM, L8:03, Karolinska University Hospital 171 Stockholm +46 8 5177 9355 / +46 8 5177 4969 40 of 227
[email protected] Department of Molecular Medicine and Surgery
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Title: Skin, Allergy and Inflammation Course number: 1552 Credit points: 1.5 Date: 2009-01-26 - 2009-01-30 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Included in postgraduate course programme: Allergy,immunology and inflammation Learning outcomes: After the course the participants, with their gained knowledge, shall be able to explain the important role of the skin to be an immunologic organ and a target for different allergic and inflammatory diseases. Contents of the course: The course includes different themes regarding the skin barrier, atopic eczema, psoriasis, urticaria and contact eczema. Type of teaching: Plenary lectures and seminars at which the course participants are expected to play an active role. Examination: At the end of the course a seminar is held at which the course participants are expected to present the results of the seminars regarding a number of subtopics in connection with the course Compulsory parts: Preparation for and attendance at the final seminar, and attendence at the lectures. The student may compensate being absent by preparing a literature study of a specific subject and a following report. Number of students: 15 - 25 Selection of students: Priority will be given to PhD students involved in skin allergy and inflammation. More detailed information: The course will be held at the Department of Dermatology, Karolinska University Hospital, Solna. - 25 Course responsible Klas Nordlind Karolinska University Hospital, Solna 08-51777882
[email protected] Unit of Dermatology and venereology Department of Medicine, Solna Course contact Klas Nordlind Karolinska University Hospital, Solna Stockhom 08-51777882
[email protected] Unit of Dermatology and venereology Department of Medicine, Solna 42 of 227
Title: Experimental techniques in study of metabolic and endocrine disorders Course number: 1559 Credit points: 1.5 Date: 2009-03-02 - 2009-03-06 Språk: english Level: Forskarnivå Responsible department: Department of Molecular Medicine and Surgery Included in postgraduate course programme: Metabolism and Endocrinology Learning outcomes: After the course the students will be able i) to measure glucose transport in isolated rodent skeletal muscle; ii) to measure lipolysis in isolated adipocytes; iii) to dissect out mouse pancreatic islets and measure the insulin release; iv) to judge and analyze obtained data. The students will learn possibilities and limitations of the described above techniques. Contents of the course: The aim of this course is to provide methodology to solve pre-clinical problems in metabolic and endocrine research. The course is laboratory based, aiming to give all participants hands on experience with isolation of pancreatic islets, skeletal muscle and adipose tissue. Theoretical and practical considerations will be presented and discussed. Type of teaching: The course meets for five days full time, including three full day laboratory practical sessions. The first day will consist of several lectures to give a background to the metabolic questions which will be addressed in the practical part of the course. Our aim is to provide the student with a hands on experience of each technique covered. In order to achieve this, for the laboratory work the course participants will be subdivided into smaller groups. Examination: The laboratory notebook examination, a short oral presentation of the project work. Compulsory parts: All three laboratory tasks are compulsory; as an exception, a written task could be given to a participant to compensate absence. Number of students: 9 - 21 Selection of students: Priority will be given to students involved in metabolic research. Preferably they should take animal course before More detailed information: Detailed time-table will be available after 2009-01-15,
[email protected] - 21 Course responsible Alexander Chibalin Integrative Physiology von Eulers väg 4a, 4tr +46-8-52487512
[email protected] 43 of 227
Department of Molecular Medicine and Surgery Course contact Lubna Al-Khalili Integrative Physiology von Eulers väg 4a, 4tr +46-8-52482260
[email protected] Department of Molecular Medicine and Surgery
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Title: Epidemiology I: Introduction to epidemiology Course number: 1577 Credit points: 1.5 Date: 2009-05-12 - 2009-06-09 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course students are expected to be able to: -give examples of the contribution of epidemiology to science and discuss the importance of epidemiology as a research discipline. -estimate and in a general way interpret measures of disease occurrence and measures of association, and describe how a specific measure is governed by the study design. -explain strengths and weaknesses of common epidemiological study designs. -identify and explain possible sources of bias in epidemiological studies. -describe theoretical models for causation and discuss the principles of causal mechanisms. -apply knowledge of epidemiological concepts when critically reviewing scientific literature. Learning outcomes are classified according to Blooms taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Contents of the course: The course gives an introduction to epidemiological theory and practice. It comprises basic principles regarding design, interpretation, and analysis of epidemiological studies. It introduces the concept of causation, concepts related to measures of disease occurrence and measures of association, common designs for epidemiological studies (with main focus on cohort studies), and the role of bias. Type of teaching: The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Different strategies for teaching and learning will be used, such as lectures, group discussions and various forms of group exercises on selected topics. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group assignments along with written and oral individual tasks. The examination is viewed as contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Compulsory parts: The examination tasks are compulsory. Number of students: 25 - 50 Selection of students: 1. Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. 45 of 227
To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: The expected learning outcomes of this course are identical with those of the ¿traditional¿ one-week Epidemiology I-course given within the Epidemiology Program and gives corresponding formal qualifications. As compared to the traditional course, however, the present course is stretched out over a longer period of time and includes less teaching occasions at Campus; a major part will be carried out outside Campus using different IT-pedagogical tools. This increased flexibility of pedagogical methods will hopefully bring about an active and effective learning process in students. Designed like this, the course may be more available for some students. Course participants are expected to attend class (at Campus Solna) on May 12 and May 26. At these occasions there will be traditional lectures as well as group sessions where participants will work together solving tasks and discussing scientific articles. At these group sessions participants may also want to plan for their up-coming web-based communication. The remaining learning activities within the course will consist of web-based exercises and assignments, mainly in groups but also individually. The main tool for the web-based learning will be the Ping Pong-platform. Course leaders are Anita Berglund and Karin Leander. - 50 Course responsible Anita Berglund IMM Box 210 17177 Stockholm +46 8 524 874 66
[email protected] Institute of Environmental Medicine Course contact Karin Leander IMM, Cardiovascular Epidemiology Box 210 17177 Stockholm 08-52487498
[email protected] Institute of Environmental Medicine
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Title: Signal transduction in brain diseases Course number: 1587 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Neuroscience Included in postgraduate course programme: The Neurosciences Learning outcomes: Knowledge and understanding: After completion of the course, the graduate student should be able to understand and describe the molecular basis of specific neuropsychiatric and neurodegenerative disorders (cf. below), with particular emphasis on the mechanisms of synaptic plasticity related to these pathological conditions. The student should also be able to understand current therapies, their efficacy and their limits. Skills and professional attitudes: The students should be able to critically evaluate and discuss advantages and disadvantages of potential interventions on signal transduction processes for the treatment of neuropsychiatric and neurodegenerative disorders. Contents of the course: The course describes alterations in signaling associated to neuropsychiatric and neurodegenerative disorders, including schizophrenia, depression, drug addiction, Parkinson's disease and Alzheimer's disease. The potential relevance of such alterations for the etiology and the therapy of the various diseases will be discussed. Type of teaching: The course will be organised as a series of presentations held by researchers working in various fields of molecular neuroscience and neuropharmacology. There will be four days of lectures and a final fifth day for the examination. Each lecture will consist of two hours of presentation followed by 45 min of discussion between the students and the speaker. Students will receive specific literature to prepare the discussion. Examination: Written examination Compulsory parts: 1) Discussion: Students will be divided into groups of 4 and each group will be asked to present two questions to discuss with each lecturer at the end of the presentations. 2) Individual written exam on the fifth day. To compensate for absence from a compulsory part the graduate student will have to report on a specific lecture or write an extra exam. Number of students: 15 - 25 Selection of students: Written motivation and degree of completion of graduate education (date of registration) More detailed information: The course will take place in the KI Campus. There may be some changes in schedule, due to the participation of foreign speakers (at least two). - 25 Course responsible Gilberto Fisone Retzius väg 8 08-52497375
[email protected] 47 of 227
Department of Neuroscience
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Title: Oxidative stress: Disease, Methods and Concepts Course number: 1620 Credit points: 1.5 Date: 2009-06-01 - 2009-06-05 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Environmental factors and health Learning outcomes: After the course the students will possess updated and basic knowledge in the rapidly evolving oxidative stress field. By poster presentations and discussion sessions the student will get training in critical appraisal of the role of oxidative stress in disease and aging relevant also to their own research. The student will learn state of the art methodological approaches and when and where to use them. Contents of the course: -The chemistry and biochemistry of endogenous oxidants and antioxidants. -Individual endogenous antioxidant defence principles and the mechanisms of their action. -Redox regulation in coordinating basal signalling and gene regulation as well as adaptive phenotypic alterations during tissue oxidative stress. -Disease mechanisms where oxidative stress and antioxidant therapies have been indicated. Cardiovascular and neurological disorders. -Oxidative stress and aging. -Radiation therapy induced oxidative stress. -Antioxidants in nutrition. -State of the art methodology in measuring oxidative stress endpoints in DNA, lipids and proteins. Type of teaching: The course consists of lectures, seminars, laboratory demonstrations and individual presentations. Examination: Oral examination Compulsory parts: Lectures and seminars are compulsary. Absence can be compensated by an essay on the corresponding subject. Number of students: 10 - 15 Selection of students: Personal motivation and secondly time since date of application as PhD student. More detailed information: The course is given at Novum - 15 Course responsible Ralf Morgenstern Nobels väg 13 171 Stockholm 52487574
[email protected] Institute of Environmental Medicine Course contact 49 of 227
Anna-Lena Marcus Nobels väg 13 171 Stockholm 5248 75 68
[email protected] Institute of Environmental Medicine
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Title: Epidemiology II. Design of epidemiological studies Course number: 1622 Credit points: 1.5 Date: 2009-02-02 - 2009-02-06 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: - in a self-directed manner, formulate the principles of different types of common epidemiological study designs. - mainly independently, explain how a specific measure of disease occurrence and measure of association is governed by the study design. - in a self-directed manner, explain and discuss epidemiological concepts, including accuracy, in the context of different epidemiological study designs. - draw conclusions from epidemiological scientific papers and to review and criticize these regarding study design, results and accuracy. Learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Contents of the course: The course focus on issues related to study design (primarily case-control methodology), study base, study efficiency, matching in epidemiological studies, induction time, interpretation of epidemiologic evidence. Type of teaching: Lectures, group discussions and various forms of group exercises on selected topics, will be used. The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group tasks along with written and oral individual tasks.The examination is viewed as a contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Compulsory parts: Only the examination tasks are compulsory. Number of students: 12 - 25 Selection of students: 1.Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. This is a second level course, and students are required to have previous knowledge in epidemiology equivalent to "Epidemiology I: Introduction to epidemiology" or corresponding courses. 51 of 227
To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: - 25 Course responsible Lars Alfredsson Box 210 17177 Stockholm +46852487488
[email protected] Institute of Environmental Medicine Course contact Anita Berglund IMM Box 210 17177 Stockholm +46 8 524 874 66
[email protected] Institute of Environmental Medicine
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Title: Cytokines in inflammation Course number: 1626 Credit points: 3.0 Date: 2009-05-25 - 2009-06-04 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: Allergy,immunology and inflammation Learning outcomes: Aim To provide an increased understanding of the function of cytokines in the healthy immune system and in different diseases. Objectives At the end of the course the particpiant should be able to: - choose adequate experimental methods to analyse cytokines depending on the scientific question - choose relevant cytokines for analysis in your research project - compare the function of cytokines in different organs and different diseases - examplify how a disease can be treated with drugs that target cytokines - describe a future treatment of a disease, where the modification of the cytokine pattern is the target Contents of the course: Learning how to measure cytokine responses and understanding the function of cytokines in immunological networks Type of teaching: The course is partly theoretical, partly practical, where lectures and laboratory exercises are integrated. Time is also allocated for discussing lab results and lectures. Examination: To pass the course, a participant has to: - actively participate in the oral discussions during the last day of the course - on the last day of the course hand in a written report in which you discuss which cytokines you would like to analyse in your own research project, motivate why, and describe and discuss which methods you would choose from the methods presented during the course. Compulsory parts: All practical sessions are compulsory. Absence from several practical sessions cannot be compensated for, but absence from one session can be compensated for in subsequent sessions. Number of students: 10 - 20 Selection of students: Students will firstly be selected based on their motivation and if they have applied to this course before. Secondly based on their date of registration. More detailed information: This course will run 9 am 5pm everyday and will include presentations by prominent international researchers as well as practical experiments around cytokine detection. Also discussion time will be scheduled both with speakers but also for group discussions and reflections over the different themes. - 20 Course responsible 53 of 227
Robert Harris CMM L8:04 51776561
[email protected] Department of Clinical Neuroscience Course contact Vivianne Malmström Rheumatology Unit, CMM L8:04, KI 08-5177 5609
[email protected] Department of Medicine, Solna
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Title: Basic course in Tumor Biology andf Oncology Course number: 1635 Credit points: 3.0 Date: 2009-04-14 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Oncology-Pathology Included in postgraduate course programme: Tumour Biology and Oncology Learning outcomes: This is a basic course for all PhD-students in the field. After the course the students will have an understanding of the cancer problem, the modern view what cancer is, from a clinical and basic science view. You will get the basic foundations of cancer biology as well as aquire some ability to discuss and understand advanced problems in cancer biology. You will have an idea which are the current most important problems to solve in cancer, to improve diagnosis, prevention, treatment and quality of life. The over all aim of the course is to form a bridge between pre-clinical and clinical aspects of tumor biology and oncology for PhD students and to provide the students an understanding of all aspects of the cancer problem. This course is a basic introduction to modern cancer research and is recommended to all PhD students within basic and clinical cancer research. Contents of the course: The course will describe the causes as well as the consequences of the transformation of a normal cell into its malignant counterpart, in order to create an understanding of cancer --from molecule to patient--, eventually also discussing the management and treatment of malignant diseasesThe topics of the course include genetics, the cell cycle, apoptosis, immunology, diagnostics and treatment, all topics presented from the cancer perspective. There will be focus on a few malignant diseases, described in more detail serving as models for basic concepts of Tumor Biology and Oncology, including molecular genetics, curative treatment and palliative care, psychosocial aspects of cancer, ethics and epidemiology. All seminars and demonstrations are compulsory, also some lectures, as well as the written examination. Single missed occasions can be compensated during the course after discussion with te course director. Type of teaching: The course consists of lectures, group seminars, group discussions and demonstrations. Full time during two consecutive weeks. Examination: Written examination with a focus on understanding of concepts, relations and how and how problems are dealt with in cancer research. Compulsory parts: This course is full time for two weeks. All seminars and demonstrations are compulsory, also some lectures, as well as the written examination. Single missed occasions can be compensated during the course after discussion with te course director. Number of students: 20 - 35 Selection of students: Based on motivation in letter of intent More detailed information: This course is full time for two weeks. All seminars and demonstrations are compulsory, also some lectures, as 55 of 227
well as the written examination. Single missed occasions can be compensated during the course after discussion with the course adminstrator. - 35 Course responsible Svetlana Lagerkrantz CMM L8:01, KS 17176 Solna +46-8-517 700 00
[email protected] Department of Molecular Medicine and Surgery Course contact Suzanne von Brömssen Radiumhemmet KS Solna +46-8-517 743 36
[email protected] Department of Oncology-Pathology
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Title: From stress to disease: an integrated view Course number: 1658 Credit points: 1.5 Date: 2009-05-04 - 2009-05-08 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Learning outcomes: After the course, the students should be able to relate the outcome of stress-induced human pathology to its physiopathological mechanisms. Also they will be able to apply their pre-exisiting knowledge of stress on various levels, from basic cellular and molecular biology to the clinical setting, and to its social and psychological aspects. Contents of the course: The course will cover: (i) the physiopathological mechanisms of stress, with emphasis on the basic cellular and molecular biology as well as on complex, multi-organic integrated responses; (ii) experimental research models of stress; (iii) stress-induced human pathology in the clinical setting; (iv) social and psychological aspects. Type of teaching: Five-day course, full-time (9:00 am - 5:00 pm), composed of lectures (5 half-days), PBL project work in small groups (3 afternoons), and final "peer-reviewed" exam. The Bologna process will be followed with a course map description on day 1. Examination: Peer-review with examinator supervision in small groups. Compulsory parts: If absence from any day a written summary of the essentials is required. Number of students: 20 - 25 Selection of students: Students must have basic knowledge available to any postgraduate student in the biomedical areas. Priority will be given to KI students, and within them to those who (i) work in the field of stress as primary research interest, or (ii) study stess-related diseases even if not primarily involved in stress research. Years of registration as PhD student as well as advancement of research plans are also selection criteria. More detailed information: More information will be available at a later time. - 25 Course responsible Rosario Leopardi Psychiatry section, KUS Solna, R5
[email protected] Department of Clinical Neuroscience
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Title: Sex hormones and Cardiovascular Disease; what do we know? Course number: 1709 Credit points: 1.5 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Sciences, Danderyd Hospital Included in postgraduate course programme: Cardiovascular research Learning outcomes: To be able to describe the interactions between endogenous and exogenous sex hormones -- both of male and female origin -- and cardiovascular disease. To be able to critically evaluate the present scientific litterature. To be able to identify important knowledge gaps and ways to close them. To be able to describe and apply relevant methodologies in the design of clinical studies Contents of the course: Lectures will cover the following fields: Review of basic physiology of sex hormones. Pathophysiology of potential sex hormone related cardiovascular diseases in the arterial and venous vasculature. Review of and critical evaluation of present pharmacological treatment with sex hormones; such as e. g. male and female contraceptives, male and female hormone replacement therapy (HRT), and primary and secondary prevention of cardiovascular diseases. Mechanistic influences of sex hormones on different parts of the vasculature. Pathophysiological influences on atherogenic and thrombogenic parts of the atherothrombotic disease entity. The course will also include overview of relevant methodologies in the assessment of the effects of sex hormones on the cardiovascular system. Type of teaching: Lectures, seminars and panel discussions. 5 days, full time. The schedule will include 4 -- 7 lectures per day, in combination with group seminars and panel discussions. Participants will perform group work where they are trained in critical evaluation of the scientific literature and design of relevant experiments and trials to solve current knowledge gaps. Panel discussions, (where experts on various clinical fields are invited) concerning evaluation of the scientific literature will be held. Totally lectures will cover about 75% of the teaching hours, the remainder will consist of group work and panel discussions. At the end of the course there will be an examination seminar. Examination: Active participation in the final examination seminar. Compulsory parts: Group seminars. Absence during compulsary parts will be compensated by a written report. Number of students: 12 - 20 Selection of students: Priority will be given to registered Ph.D. students with projects within the field of the course and motivation given in the application. More detailed information: - 20 Course responsible 58 of 227
Peter Henriksson Danderyd University Hospital, SE 182 88 Stockholm,Sweden +46 8 6555000
[email protected] Department of Clinical Sciences, Danderyd Hospital Course contact Aleksandra Antovic Danderyd University Hospital, SE 182 88 Stockholm, Sweden +46 8 6557334
[email protected] Department of Clinical Sciences, Danderyd Hospital
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Title: Pain mechanisms: From molecules to treatment Course number: 1727 Credit points: 1.5 Date: 2009-06-01 - 2009-06-05 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: The Neurosciences Learning outcomes: After the course the student should be able to: ¿ Evaluate the mechanisms of various pain states as studied experimentally. ¿ Relate the occurrence of pain through its anatomy, physiology, neurochemistry and neuropharmacology. ¿ Evaluate together with clinician scientists how the knowledge from experimental studies will be translated to the clinic. ¿ Distinguish various pain states, for example acute vs neuropathic pain. ¿ Preclinical students shoud be able to relate basic science to the clinic. ¿ For clinician students an understanding of basic pain mechanisms should help them analyse the mechanisms underlying patients' pain states. Contents of the course: The course will consist of basic science to study pain mehchanisms, tha pharmacology of pain, the role of genetic factors, clinical studies and discussions of translational research between basic science and the clinic. Type of teaching: Lectures, seminars, round table discussions, laboratory demonstrations, clinical demonstrations Examination: The examination for all students will consist of some multiple choice questions from each teacher. In addition, essays and/or project presentations and discussions for all students will be included. Compulsory parts: Number of students: 5 - 10 Selection of students: Priority will be given to PhD students wit documented experience in pain research for at least 3 months. Please describe which laboratory and type of work performed at the lab. More detailed information: The course will be given at the University of Minnesota, Minneapolis with faculty from KI and U Minn. Please see detailed course curriculum PAIN MECHANISMS: FROM MOLECULES TO TREATMENT June 1-5, 2009, University of Minnesota - 10 Course responsible Zsuzsanna Wiesenfeld-Hallin 60 of 227
Karolinska university hospital Huddinge C176 141 Stockholm 585 87085
[email protected] Section of Clinical Neurophysiology Department of Clinical Neuroscience Course contact Zsuzsanna Wiesenfeld-Hallin Karolinska university hospital Huddinge C176 141 Stockholm 585 87085
[email protected] Section of Clinical Neurophysiology Department of Clinical Neuroscience
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Title: The Cerebral Cortex: Organisation and Dynamics Course number: 1729 Credit points: 3.0 Date: 2009-05-04 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Neuroscience Included in postgraduate course programme: The Neurosciences Learning outcomes: After the course the students will have a basic knowledge of the organisation, function and dynamics of the Cerebral Cortex in mammals. The aquired knowledge will help to understand and critically evaluate concepts and theories on the function of the cerebral cortex. Contents of the course: Lectures by leading international scientists who will share with the students the latest contributions to our understanding of the cerebral cortex. Areas covered include: Single neuron computing, anatomy and physiology of different cortical cell types, microcircuit properties, neuronal and population codes, interaction between cerebral cortex and subcortical nuceli, theories on the function of cerebral cortex. Type of teaching: Lectures and student seminars Examination: Examination will be in the form of an oral student seminar where students show through active participation that the have aquired the necessary knowledge to understand key concepts on the structure and function of the cerebral cortex. Compulsory parts: Compulsary attendence to all lectures and the examination. In case of absence, a possible compensation will be discussed with the course leader. Number of students: 15 - 50 Selection of students: Priority will be given to students with background knowledge in Neuroscience. More detailed information: Appendix A: List of invited speakers. Appendix B: Schedule. Location: Karolinska Inst. The course period is subject to change depending on the availability of the invited speakers. Course examinators will also be Gilad Silberberg and Per Roland. - 50 Course responsible Patrik Krieger Retzius väg 8, Karolinska Inst 08-524 87349
[email protected] Department of Neuroscience Course contact Iris Sylvander Retzius väg 8 62 of 227
52486901
[email protected] Department of Neuroscience
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Title: Exercise in the management and prevention of metabolic diseases Course number: 1790 Credit points: 1.5 Date: 2009-05-25 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department of Molecular Medicine and Surgery Included in postgraduate course programme: Metabolism and Endocrinology Learning outcomes: Participants will be able to explain the health-related benefits of exercise from a physiological perspective Contents of the course: The aim of this course is to address the current understanding of the role of exercise in the prevention and treatment of diseases associated with an increasingly aging sedentary population. Lectures will cover the metabolic, physiological and molecular responses to exercise in health and disease. A current understanding of the basic molecular and cellular events governing the acute and chronic exercise response will be provided. Adaptation of skeletal and cardiac muscle and the cardiovascular system to exercise will be considered. Topics include strategies for exercise prescription in various clinical situations including: the care and prevention of congestive heart failure and other cardiac disorders, diabetes, obesity, musculoskeletal disorders, and frailty. Type of teaching: This course will be composed of interactive seminars, lectures, laboratory practicals, group work, group presentations and discussion. Examination: Students will be assessed by their group presentation (10 min). In addition to this, each student will make a written summary of the specific research project in wich he/she was participating. Compulsory parts: Laboratory practicals and group works are compulsory. Students that are not able to attend to a part of the course, as a compensation, could do a self-study and write an essay on the topic(s) that they have missed. Number of students: 30 - 60 Selection of students: Priority will be given to 1) students with basic knowledge in metabolism and exercise physiology 2) written motivation and date of registration will also be used as selection criteria. More detailed information: The majority of the course will take place at Karolinska Institutet, Campus Solna. Some lectures and laboratory practicals will be given at Gymnastik och Idrottshögskolan in Stockholm, Lidingövägen. Some speakers are invited from the USA and from other Swedish universities. Regarding the examination, due to the fact that three USA Universties will be participating in the course, the individual written summaries shall be handed in at the latest two weeks after the end of the course, and will be reviewed by the course organizers. Individual feedback to the students will be provided. All summaries will be put together as a compendium and handed out to the students. - 60 Course responsible Pablo M. Garcia-Roves Integrative Physiology 64 of 227
von Eulers väg 4a,4tr 171 Stockholm 08-524 87512
[email protected] Department of Molecular Medicine and Surgery Course contact Margareta Svedlund von Eulers väg 4a 17177 Stockholm +46852487581
[email protected] Integrative Physiology Department of Physiology and Pharmacology
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Titel: Studiedesign vid klinisk forskning Kursnummer: 1794 Antal högskolepoäng: 4.0 Datum: 2009-02-20 - 2009-04-17 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för molekylär medicin och kirurgi Kursens lärandemål: Efter kursen ska kursdeltagaren/doktoranden ha förvärvat kunskaper avseende grundläggande begrepp inom klinisk/epidemiologisk forskning, de viktigaste felkällorna samt kausalitetsbegreppet. Kursdeltagaren/doktoranden ska efter genomgången kurs kunna argumentera för såväl fördelar som nackdelar med olika studiedesigner på ett vetenskapligt konstruktivt sätt. Kursens innehåll: Grundläggande begrepp inom klinisk/epidemiologisk forskning, de viktigaste felkällorna samt kausalitetsbegreppet. Arbetsformer: Föreläsningar, projekt-/grupparbete, artikelgranskning och muntlig examination. Examination: Aktivt deltagande i projektarbete, artikelgranskning och muntlig presentation. Obligatoriska moment: Deltagande vid samtliga seminarietillfällen samt aktivt deltagande i grupparbete/hemuppgifter.. Antal studenter: 12 - 15 Urval av studenter: Urvalet baseras på den motivering som den sökande lämnar vid ansökningstillfället. Ytterligare information: Kursen omfattar 2.5 veckors heltidsarbete och pågår under 7 veckor. Kursen är upplagd med 7 schemalagda kursdagar samt två examinationsuppgifter bestående av 1) individuellt projektarbete och 2) artikelgranskning. Schemlagda kurstillfällen är fredagseftermiddagar vid följande datum: 20/2, 6/3,13/3, 20/3, 27/3, 3/4, 17/4 2009. Ansvarig för kurstillfälle Helena Nordenstedt Karolinska Institutet ESOGAR P9:03, 17176 Stockholm 0709-625170
[email protected] Institutionen för molekylär medicin och kirurgi Kontaktperson för kurstillfälle Margrete Gellervik ESOGAR P9:03, Karolinska Institutet, 17176 Stockholm +46851770957
[email protected] Institutionen för molekylär medicin och kirurgi 66 of 227
Title: Data Collection- and Analysis I: Introduction to Qualitative Methods Course number: 1816 Credit points: 4.0 Date: 2009-03-03 - 2009-04-01 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Included in postgraduate course programme: Health Care Sciences Learning outcomes: After the course the students should be able to: Understand the principles that form the basis of making a standpoint in choosing methods of qualitative data collection and data analysis. Understand different ways of reaching thrustworthiness in qualitative research. Understand different methods of data collection and analysis of qualitative data and its applicability within the health care research. Apply one of the methods to the students own research Contents of the course: Scientific and philosophical domicile of qualitative research Methods of data collection and analysis most common in qualitative health care research Validation of qualitative research Type of teaching: The course will consist of lectures, supervision and seminars. The course is spread over 5 weeks with 5 teaching occasions, with the first one as an introduction and the 3 following as lectures with seminars. In between these lectures the student will study indivually and have access to electronic tutoring. The 5th and last occasion will be an critical discussion seminar. Examination: The examination will consist of review of research literature which will be reported both in writing and discussed in seminars. Compulsory parts: Taking part in all seminars is compulsory. Absence from seminars is to be compensated be a written critical discussion on a theme related to the seminar content. Number of students: 15 - 30 Selection of students: Priority is given to registered students within the Postgraduate school in Health Care Sciences. More detailed information: The course is given 3-4/3, 10-11/3, 17-18/3, 31/3 and 1/4 at the School of Health and Medical Sciences, Örebro University. - 30
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Course responsible Lena von Koch Fack 23 200 141 Huddinge 070 513 30 55
[email protected] Sektionen för arbetsterapi Department of Neurobiology, Care Sciences and Society
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Title: Introduction to test theory and test/survey methodology Course number: 1817 Credit points: 4.0 Date: 2009-04-15 - 2009-05-11 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Included in postgraduate course programme: Health Care Sciences Learning outcomes: The aim of the course is to provide the course participants with a deeper understanding in concepts and principles to guide the choice of quantitative data gathering and analytic procedures within health care sciences. The student should after finalizing the course be able to: - Analyze, judge, and choose appropriate methods for quantitative data gathering procedures - Analyze, judge, and choose appropriate methods for analyzing and interpreting quantitative data - Analyze and discuss quality criteria for quantitative research in health care sciences Contents of the course: The content of the course is primarily based on aspects related to systematic quantitative data gathering processes. The course introduces: - The measurement process and the different aspects included in this process - Modern test theory and current definitions of concepts - Different quantitative data gathering methods - Approaches for construction, application, analysis, and evaluation of clinical tests/questionnaires The course content is individually adjusted for examining a specific aspect of data gathering processes (a clinical test/questionnaire/survey) that is chosen by the student and related to his/her own research project. This aspect is presented by the student during the first day of the course and will guide the individual learning processes. Type of teaching: The pedagogic framing of the course is centred around the student's own research project. The contents of the course are introduced in lectures and clinical applications. The students are then applying the processes/methods learned in workshops and group work with supervision. The outcomes are then presented and discussed in seminar forms. The student is finally applying the course content on an individually chosen aspect of quantitative data gathering processes in his/her own research project. Examination: The examination consist of a written paper based on the individually chosen aspect of quantitative data gathering processes in the student's own research project. The quality of the paper is judged according to the leaning outcomes in relation to specific given criteria in the course.
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The paper is also presented in a seminar. Compulsory parts: Seminars are mandatory. A student will be able to compensate absence with written assignments. Number of students: 12 - 24 Selection of students: Priority is given to registered students within the Postgraduate school in Health Care Sciences. Postgraduate students within Health Care Science and associated research areas are welcome to apply and will be selected based on the written motivation. More detailed information: The course is given 15-16/4, 22/4, 28-29/4, 4/5, 6/5, 8/5 and 11/5 - 24 Course responsible Anders Kottorp Alfred Nobels Allé 23 Huddinge +46 8 52 48 38 28
[email protected] Sekt. för arbetsterapi Department of Neurobiology, Care Sciences and Society Course contact Malin Lindell Alfred Nobels Allé 23 Huddinge +46 8 52 48 38 30
[email protected] Sekt. för arbetsterapi Department of Neurobiology, Care Sciences and Society
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Title: Interview techniques in health and care research Course number: 1818 Credit points: 4.0 Date: 2009-01-14 - 2009-02-12 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: Health Care Sciences Learning outcomes: After the course the student is expected to be able to identify and understand the content of a research interview. Demonstrating and mastering necessary interview tools in order to, independently, being able to analyze and adapt this knowledge and practical skills in order to compose; i.e. to plan, design and to conduct a research interview. Communicating and giving feedback to other students relating knowledge with practical demonstrations. Furthermore to have gained an increased understanding and a professional attitude of the researcher as an instrument for data collection which can be applied and enhance the quality of data in future research interviews. Contents of the course: *different perspectives and knowledge for conducting interviews the role of empathy in communication the researchers role as an instrument in data collection *intersubjectivity, biases and ethical considerations of interviewing *how to plan an interview guide *how to formulate questions *how to conduct an interview with respect for culture and vulnerable groups Type of teaching: The course will be offered part-time, either mornings (9-12 a.m.) or afternoons (1-4 p.m.), on average 8 hours per week including; lectures, video demonstrations covering various interviews and interview techniques, interview technique training seminars in small groups, supervision seminars (interview guide), literature seminars and self-monitored studies and practise. Since interview training is a process which requires testing ¿in vivo¿, improvements, reflection between training, the course covers a 5-week period. Examination: Examination will consist of an interview guide and of an individually taped documentation of an interview with a research subject in the own research field presented in the course group. The presentation will furthermore be within a theoretical frame of reference including the course literature, discussing interviews, interview techniques, potential biases challenging the quality of the interview responses. The reason behind choosing this kind of examination is that it has been proven to give earlier interview student-groups valuable learning experiences which immediately can be applied in their research area. Compulsory parts: The education will be compulsory scheduled all through the course. If the student is unable to be present he/she has to consult the course leader/examinator for adequate opportunities to recover missed hours (usually in the form of written assignments, besides the video-taped interview). Number of students: 8 - 12 Selection of students: All students are welcome to apply. However priority is given to registered students within Postgraduate school 71 of 227
in health care sciences. More detailed information: The course is mainly scheduled Wednesday afternoon/Thursday morning except for the examination sessions in February; i.e. Wednesday 11th and Thursday 12th, which will run 9 a.m. to 4 p.m. The course will be given at the Division of Psychiatry at Huddinge Campus. - 12 Course responsible Gunnel Backenroth-Ohsako Karolinska University Hospital at Huddinge, M56 +46 8 585 865 46
[email protected] Division of Psychiatry Department of Clinical Neuroscience Course contact Britta Weckström Karolinska University Hospital at Huddinge, M56 +46 8-585 866 23
[email protected] Division of Psychiatry Department of Clinical Neuroscience
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Title: Introduction to multivariate data analysis Course number: 1819 Credit points: 4.0 Date: 2009-05-13 - 2009-06-03 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Included in postgraduate course programme: Health Care Sciences Learning outcomes: After the course the participants should be able to apply the methods of linear and logistic regression to analyse data and to know which assumptions these methods rely on. Contents of the course: The course will focus on regression analysis, multiple linear regression, logistic regression and regression methods for ordinal data. Apart from this core a simple nonparametric regression will be introduced as an exploratory method. Methods for the analysis of longitudinal data will be discussed. Other multivariate methods including factor analysis and structural equation modelling will also be discussed. Type of teaching: The course will consist of lectures, seminars and computer exercises. The lectures will cover the theoretical material illustrated with relevant examples. Some material will be presented in seminar form typically discussing an article that the participants have read. In the computer exercises the participants will apply their knowledge practically. This work will be handed in and be part of the examination. The course will be spread out over 5 weeks and will consist of a total of seven days. Examination: The course examination will consist of written work from the three computer exercises (3*2-3 pages) where results will be presentet and discussed. Compulsory parts: Preparation for and active participation in the three seminars. If absent from a seminar the participant will have to hand in a written assement. Number of students: 15 - 20 Selection of students: Priority is given to registered students within the Postgraduate school in Health Care Sciences. Other applicants are selected based on the written motivation. More detailed information: The course is given 13-15/5, 27-28/5 and 2-3/6. - 20 Course responsible Daniel Olsson Berzelius väg 3 +46852483741
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt 73 of 227
LIME Berzelius väg 3, KI Campus Solna 852487118
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Practical Course in Microscope-based fluorometry in living cells Course number: 1820 Credit points: 1.5 Date: 2009-05-11 - 2009-07-31 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Science and Education, Södersjukhuset Learning outcomes: At the end of this course, the participants will be able to: 1. understand the essential components and configurations of microscope-based fluorometry instrument systems for live cell experiments 2. understand the scope of application and potential shortcomings of such methods 3. measure fluorescence from single living cells and thereby measure concentrations of ions, second messengers, and monitor metabolic events from single living cells 4. select fluorescent probes for different aplications and their use 5. choose appropriate filters and dichroics for different applications. 6. use of dual excitation and dual emission ratiometric probes 7. calibrate and analyse results for quantification and presentation Contents of the course: Microscope-based fluorometry is a powerful technique for studying intracellular ionic, signaling and metabolic events in single living cells. The contents of this course include: 1. practical training in instrument configuration, choice of filters- dichroics, monochromators and recording systems 2. choice of fluorescent probes, dye loading, use of dual excitation/emission ratiometric probes. 3. Measurements of intracellular ions, signaling molecules and metabolic parameters from single living cells. 4. analysis and interpretation of results obtained with such systems. Day 1 will be dedicated to a short presentation and discussion on the theoretical aspects of the techniques. Each pair of participants will then have two days of practical training in the use of the system. Type of teaching: Day 1 will be dedicated first to a short presentation and discussion on the theoretical aspects of the techniques. Each pair of participants will then have two days of practical training in the use of the system. One-two students will be invited to the course at a time. Trained supervisors will be present for deminstration and supervision. Examination: Participants will be examined individually for their ability to understand the essential components of the instrument system, use the system and analysis/interpretation of the results. Compulsory parts: Number of students: 10 - 20 Selection of students: The selection is based on the relevance of the course content for the research project and a personal motivation letter. Registered PhD students are given priority. Each year we receive some participants from outside Sweden too. More detailed information: It is a laboratory course. We take 1-2 students at a time for two days, in the lab. The dates for individual students are decided through discussion with the supervisors and the students. - 20 Course responsible Shahidul Islam Research Center 3rd Floor, 11883 Stockholm 75 of 227
8-6163950; 0702593446
[email protected] Department of Clinical Sciences and Education Department of Clinical Science and Education, Södersjukhuset Course contact Shahidul Islam Research Center 3rd Floor, 11883 Stockholm 8-6163950; 0702593446
[email protected] Department of Clinical Sciences and Education Department of Clinical Science and Education, Södersjukhuset
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Title: Regressionanalysis Course number: 1827 Credit points: 4.5 Date: 2009-02-09 - 2009-03-06 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: After the course the participants should be able to apply the methods of linear and logistic regression to analyse data and to know which assumptions these methods rely on. Contents of the course: The course will teach how medical data can be analysed using regression analysis. The course will cover exploratory methods, multiple linear regression for continuous variables, logistic regression for categorical variables and Cox regression for surival data and an introduction to the analysis of repeated measures and more advanced methods. Particular emphasis will be put on diagnostics and investigation whether the model fits the data and if there are infuential observations. A large part of the course the participants will spend on a project, where the participant has the opportunity to work on his/her own data and thereby apply and deepen their knowledge. Type of teaching: The course will consist of lectures, seminars and computer exercises. The lectures will cover the theoretical material illustrated with relevant examples. Some material will be presented in seminar form typically discussing an article that the participants have read. In the computer exercises the participants will apply their knowledge practically. This work will be handed in and be part of the examination. The course will be spread out over 5 weeks and will consist of a total of ten days. Remaining time will be spent reading the course litterature and working with a project to be presented on the final day of the course. Examination: The course examination will consist of active participation in the three seminars,written work from the four computer exercises (4*2-3 pages) where results will be presented and discussed and finally the completion and oral presentation of their project work. Compulsory parts: Preparation for and active participation in the three seminars. If absent from a seminar the participant will have to hand in a written assement. Number of students: 15 - 20 Selection of students: Prior participation in the basic course in medical statistics or equivalent is a minimum requirement. The selection of course participants will be based on the motivation that the applicant hands in at the time of application. More detailed information: - 20 Course responsible Daniel Olsson Berzelius väg 3 +46852483741
[email protected] 77 of 227
Department of Learning, Informatics, Management and Ethics Course contact Margareta Krook-Brandt LIME Berzelius väg 3, KI Campus Solna 852487118
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Clinical Immunology in Infectious Diseases Course number: 1832 Credit points: 3.0 Date: 2009-03-16 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Huddinge Included in postgraduate course programme: Infection Biology Learning outcomes: By completing this course the students will be able to account for different immunological processes in the host defence against pathogens. In particular, the students will be able to explain the concepts of innate and adaptive immunity and their important roles at different stages in the host defence against pathogens. Student will also be able to describe differences in acute and chronic infections with respect to immunological processes. In addition, the students will be able to give details about different pathogens and explanations for their different strategies of immune deviation. Finally, this course will increase the students-- skills to communicate research projects. Contents of the course: This course is mainly made up of lectures and seminars. Review articles related to the lectures distributed during the course. In addition, some parts of the course involve team-work. The following will be covered during the course: Immunological processes important in the host defense against pathogens; Innate and adaptive immunity; Strategies used by pathogens to subvert the host immune system to avoid eradication; Acute and Chronic infections; Emerging infections; Infections and the link to autoimmune disease; Pathogens that will be covered are bacteria, viruses, parasites and fungi; The latest therapies used in the clinics to fight infections. The course also involves site visits to the Infectious disease clinic and the intensive care unit. As exam, the students will have both a written and oral assignment. This includes writing a brief research proposal within the field of infection and immunity as well as presenting the proposed research for the course participants. Type of teaching: Lectures, team-work and project assignment (written and oral), peer-and self assesement and oral presentations. Examination: Project assignment (written and oral presentation) Compulsory parts: Lectures, project work (written assignment) and the day of examination (oral exam), is compulsory. Compensation for absence from oral presentation may be possible after discussion with the course organisers. Possible actions may include an oral examen at a separate occasion with the course organizers. Number of students: 15 - 20 Selection of students: Priority will be given to students on the base of their motivation and topic of PhD project and secondly depending on length since registration. More detailed information: The course will be given at the Karolinska University hospital in Huddinge. - 20 Course responsible Mattias Svensson Center for Infectious Medicine, F 59 Karolinska Institutet , Karolinska University hospital 79 of 227
141 Huddinge +46 8 585 896 87
[email protected] Center for Infectious Medicine Department of Medicine, Huddinge Course contact Linda Johansson CIM F59 Karolinska hospital Huddinge 141 Stockholm 08-58582276
[email protected] Department of Medicine, Huddinge
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Title: Artery function in health and disease Course number: 1876 Credit points: 3.0 Date: 2009-05-25 - 2009-06-05 Språk: english Level: Forskarnivå Responsible department: Department for Clinical Science, Intervention and Technology Included in postgraduate course programme: Cardiovascular research Learning outcomes: After the course: 1.Students should be able to list and explain the fundamentals about the physiological regulation of small artery function and its importance for cardiovascular maintenance. 2. Students should understand the basic principals of techniques relevant to investigate the functional properties of endothelial and smooth muscle function. 3. Students should be able to describe the importance of endothelium-derived factors in relation to their mechanisms of action for the regulation of artery tone. 4. Students should understand and critically reflect on the phenomenon of ¿endothelial dysfunction¿ and its role in cardiovascular maintenance with particular focus on fetal programming, reproduction and menopause, sex differences in the regulation of artery tone, as well as its implications for the development of certain cardiovascular complications. Contents of the course: The course is designed to provide an overview of "hot topics" in vascular biology and medicine. The course will include theoretical lectures covering physiology and pathophysiology of resistance vasculature with focus on endothelium-derived factors, oxidative stress, fetal programming and later cardiovascular health, reproductive cardiovascular health, vascular remodelling and implications for the improvement of endothelial health. In parallel, additional time will be used for corroboration of acquired knowledge with experimental work in laboratory in order to obtain basic skills for ex-vivo evaluation of artery function. Finally, discussion panels on main topics of interest will be organized. Type of teaching: The course includes comprehensive lectures that describe most important topics relevant for the course. Each speaker will be ask to provide 3 questions that should be strictly referred to the subject treated during the presentation in order to demonstrate the level of student's comprehension. These questions will be used during final examination. Moreover, at the end of each lecture, the course organizer together with lecture will initiate the whole group discussion on the key message of the topic to enhance the learning process and for critical assessment of acquired information. Based on the student's background and scientific interest, buzz groups will be organized for project work in respect to topics selected by course organizer. The experience at individual scientific level will be promoted in order to implement in the group work. Final around table session will serve as a part for final examination, at which projects will be introduced by each group and questioned by others. The course organizer and its scientific staff will assist during individual group work for project planning etc. Finally the practical work supplemented by video films relevant to experimental work will also strengthen the learning process. During the practical experiments PhD students and post docs at hosted lab will assist for teaching making possible for each participant during his/her practical self-training (hands on). Examination: Oral presentation and a round table discussion on a topic introduced by course leader for a group work. 81 of 227
Moreover, a written examination will be performed to answer questions prepared by each lecturer and course organizer. Compulsory parts: All lectures are obligatory. Special reasons for absence can be discussed, and absence from specific lectures will be compensated through oral examination of the lecture's content with the course teachers. Participation in the laboratory practicals and demonstrations is mandatory, as well as in the group work for project preparation and presentation. Compensation will required through an individual written assignment. Number of students: 15 - 30 Selection of students: Priority will be given to PhD students involved in cardiovascular research and secondly to date since registered as PhD student. More detailed information: The course will be held in English and will take place at Karolinska University Hospital, Huddinge. Laboratory space and lecture rooms will be concentrated at NOVUM and hospital. The number of invited international speakers will be participating. For previous programs, please don't hesitate to contact
[email protected] - 30 Course responsible Karolina Kublickiene Karolinska Universitetssjukhus-Huddinge 46-8-5858 3959
[email protected] CLINTEC, enh.. Obstetric Gynekologi Department for Clinical Science, Intervention and Technology Course contact Lisbeth Löfstrand Karolinska Universitetsjukuset Huddinge 46-8-5858-1657 lisbeth.lö
[email protected] Enh. Obstetric och gynekologi Department for Clinical Science, Intervention and Technology
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Title: Pathogen/Host Interactions Research Seminar Series Course number: 1877 Credit points: 3.0 Date: 2009-01-14 - 2009-05-06 Språk: english Level: Forskarnivå Responsible department: Department of Microbiology, Tumor and Cell Biologi Included in postgraduate course programme: Infection Biology Learning outcomes: After the course, the students are expected to have improved their knowledge of the mechanisms regulating host-microbe interactions, and they should be more aware of the frontline research activities of the scientific community in the field. More specifically, they should be able to compare and differentiate the different processes and the different molecular players that are involved in the interactions between the host and the various microbial agents such as viruses, bacteria, parasites etc. Since the course is organized to encourage analytical and critical thinking, they should also be able to evaluate the relevance of the topics discussed for their future research activities and PhD studies. Contents of the course: By discussing selected examples of host/microbe interactions during the lectures, the course will particularly focus on the routes and mechanisms of infection, the susceptibility and the response of the host to such infections, and the molecular and physiological events leading to the clearance of microbes or a diseased state. Innate and adaptive immunity, inflammation, and the biology of membranes and receptors will thus also represent main topics for the discussions, which will be held to meet the students¿ main scientific interests. Type of teaching: The course is organized in a series of 15 lectures/seminars, held by invited speakers from Karolinska Institutet and other institutions in Sweden, who will be asked to organize their talks to give a comprehensive pedagogical review of the area, as well as a description of their own research. Three keynote seminars will be provided by scientists from abroad who represent international leading experts in the field of host-microbe interactions. Each seminar will be followed by a scientific discussion led by the course organizers, where the students are expected to actively interact with the invited speaker. They are therefore required to prepare before hand by reading literature pertinent to the talk, which will be provided by organizers upon speakers¿ suggestion. Examination: For the final examination, the students will be divided into groups and assigned a scientific subject related to a specific area of host-microbe interactions. Full credit (3 points) will be given to the students following an exam that will take the form of an oral presentation, based on the implementation of provided literature with the concepts and ideas discussed during the course on the specific subject. The students will be required to judge other groups¿ work by asking them questions and filling in a questionnaire at the end of the exam. The overall assessment of the students will thus be based on their presentation, the participation to the discussion, and the questionnaire. Compulsory parts: Keynote lectures (held by leading experts from abroad) are compulsory. Students who can not attend seminars will be required to write a half page summary of the seminar material for each of the seminars they did not attend. Number of students: 6 - 50 Selection of students: Priority will be given to students with basic knowledge of molecular and cellular biology and there interest in 83 of 227
infection biology More detailed information: There will be no seminar the week before the easter break. There will be a seminar each other week at 1pm on Wednesdays. An exam will be held in the last week of the course. This is in the form of a presentation of material presented in the keynote seminars. Three keynote speakers will be invited to give seminars. Attendance at keynote lectures is compulsory. If a student is unable to attend a seminar they will be required to write a half page summary of the course literature for that seminar. - 50 Course responsible Laura Plant Nobels väg 16 17177 Stockholm 08 524 86312
[email protected] Department of Microbiology, Tumor and Cell Biologi Course contact Laura Plant Nobels väg 16 17177 Stockholm 08 524 86312
[email protected] Department of Microbiology, Tumor and Cell Biologi
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Title: Biostatistics IV: Applied Longitudinal Data Analysis Course number: 1895 Credit points: 2.0 Date: 2009-04-14 - 2009-04-22 Språk: english Level: Forskarnivå Responsible department: Department of Medical Epidemiology and Biostatistics Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: - Describe the statistical methods utilized to analyze longitudinal data in a variety of settings and with a variety of types of outcome variables. - Analyze a scientific problem that requires repeated measurements, identify an appropriate design, and identify the statistical methods required to analyze the data. - Utilize statistical software (e.g., SAS procedures GLM, MIXED, GENMOD and NLMIXED) to perform longitudinal analyses of data generated from randomized and observational studies with repeated measures designs. - Apply modern methods for the analysis of longitudinal data to a range of settings encountered in biomedical and public health research. - Interpret and communicate the clinical/scientific meaning of the results of a longitudinal analysis. Learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation. Contents of the course: The course gives an introduction to modern methods for the analysis of longitudinal and repeated measures studies which are commonly used in epidemiological studies and in clinical trials. The defining feature of a longitudinal study is that measurements of the response are taken repeatedly through time. The primary goal of a longitudinal study is to characterize change in the response over time and the factors that influence change. A feature of longitudinal data that complicates their analysis is the positive correlation (i.e., lack of independence) among repeated observations and possible heterogeneity of variability across measurement occasions. The first part of the course covers general linear regression models for longitudinal data when the response variable is continuous. The course covers the following topics: Introduction to longitudinal data, notation for correlated data, modeling the mean response (analysis of response profiles, parametric and semi-parametric trends), modeling the covariance, growth curves, linear mixed effects models. The second part of course presents an overview of methods for analyzing and interpreting the results of longitudinal studies when the outcome variable is discrete. This course covers general regression models for longitudinal data when the response variable is discrete (e.g., binary or count data). Topics covered in the course will include: introduction to generalized linear models (e.g., linear, logistic, and Poisson regression), extensions of generalized linear models to longitudinal data, marginal models and GEE, random effects models for categorical data (generalized linear mixed models), contrasting marginal and mixed effects models. The course is intended for all students interested in epidemiology, biostatistics and public health. 85 of 227
Type of teaching: Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software, group discussions, literature review. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group assignments and an individual written examination. The focus will be on understanding concepts and their application to analysis of epidemiological studies, rather than mathematical detail. The examination is viewed as a contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms then a third examination will be scheduled within 12 months of the final day of the course. Compulsory parts: Only the examinations are compulsory. Number of students: 12 - 25 Selection of students: 1.Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology", "Biostatistics I: Introduction for epidemiologists" and "Biostatistics II: Logistic regression for epidemiologists" or corresponding courses is required. Prior knowledge equivalent to "Biostatistics III: Survival analysis for epidemiologists" or corresponding knowledge is recommended. To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: Teacher: Garrett Fitzmaurice, Foreign Adjunct Professor of Biostatistics, Department of Medical Biostatistics and Epidemiology, KI & Associate Professor in Biostatistics, Harvard School of Public Health. The course is offered April 14 to April 22, 2009. Lectures will be from 9:00 to 12:00, every day of the course, and computer laboratories will run in the afternoon from 13:00 to 15:00. - 25 Course responsible Rino Bellocco Nobelsväg 12 A 17177 Stockholm +46852486183
[email protected] Department of Medical Epidemiology and Biostatistics Course contact Marie Dokken Box 281, 171 77 Stockholm Stockholm +46852482341
[email protected] Department of Medical Epidemiology and Biostatistics
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Title: Surgical techniques in rat and mouse Course number: 1978 Credit points: 1.5 Date: 2009-05-25 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department for Clinical Science, Intervention and Technology Learning outcomes: After the course the participants are expected to 1.To use and understand the importance of aseptic surgical technique 2.Be able to identify and give examples of important ethical aspects on study design and methodology in research projects involving animals and to communicate this knowledge to peers. Contents of the course: Anaesthesia, analgesia and perioperative care, aseptic surgical techniques, basic surgical techniques including instrumentation, suturing and tissue handling, vein and artery cannulation and explorative laparotomy. Rat will be our main model during the course (as techniques is easier to learn in a larger model), but mouse will also be available. Type of teaching: A minor part of the learning activities are lectures (20-25%). The remianing part of learning activities are laboratory work with practical instructions and learning in jigsaw groups (tutoring available). Examination: Assessment of learning outcomes To satisfactorily complete the course the student must 1.Be able to perform a simple surgical procedure using aseptic technique 2.In a written report of a provided fictive research projects demonstrate that you have reached the learning outcome (no 2 above). Compulsory parts: The learning in jigsaw groups are compulsory. Absence can be compensated by a written report. Number of students: 12 - 16 Selection of students: The following student factors are premiated: 1. previous experiences in animal surgery 2. students with experimental projects that will clearly benefit from the course We aim to select students with different experimental interest, i.e. neurosurgery, intestinal surgery, cannulation etc. More detailed information: Invited lecturer and instructor René Remie, Professor in Experimental Surgery, Groningen University, The Netherlands - 16 Course responsible Lisa Strömmer Gastrocentrum K53 Karolinska Huddinge 736994483
[email protected] Enheten för kirurgi 87 of 227
Department for Clinical Science, Intervention and Technology
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Title: How to write a scientific paper - and get published Course number: 1988 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: The aim is that participants achieve a solid understanding of scientific written communication and raise their competence in writing articles, and in handling the process of getting articles published. The students should have started the process of writing scientific articles already before the course. After the course the participants should know how to write articles reporting both quantitative and qualitative data, how to avoid the most common mistakes, how to select an appropriate journal, how to respond to reviewers' comments and how to communicate with editors. The course is most useful for students in the research fields of public health, caring sciences, clinical practice, epidemiology and applied medicine. Contents of the course: Science as communication The writing process: structure, language, style, the elements of a scientific article Writing an article with quantitative data Writing an article with qualitative material Assignments to write parts of an article with own material Feedback on written assignments for group discussions and reflections Reviewing assignments by other students Case work on the review process Publishing articles from the Editor's point of view Type of teaching: Interactive plenary sessions are combined with group work with or without teachers. Group work includes focused exercises and case discussions. The course is based on participants' written assignments with material from their own research. These assignments are assessed by teachers and feedback regarding style and content is given during the course, both on an individual and on a group level. The students are also assigned to comment on other students' exercises. Time is allocated for individual work on assignments and for reading the course literature. One assignment should be delivered before the start of the course. Examination: The examination takes the form of assessment of the students' competence to respond to feedback and improve their skills in scientific writing during the course. The level of performance regarding the final assignments are the basis for this evaluation. Compulsory parts: The plenary sessions and the group work are compulsory as well as the written assignments. Absence has to be compensated at an individual level. Number of students: 16 - 32 Selection of students: 1) registered at KI in focused fields (public health, caring sciences, epidemiology, applied medicine); 2) oldest registration date. More detailed information: The course is focusing PhD students in the fields of public health, caring sciences, epidemiology and applied medicine. A written task is requested before the course start. - 32 89 of 227
Course responsible Rolf Wahlström Nobels väg 9 17177 Stockholm 08-54283355
[email protected] Department of Public Health Sciences Course contact Helena Faxelid Nobels väg 9 17177 Stockholm 08 524 833 76
[email protected] Department of Public Health Sciences Course contact Gunilla Risberg Nobels väg 9 17177 Stockholm 4685283349
[email protected] International Health Department of Public Health Sciences
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Title: Good Data Management Practice in Epidemiological Research Course number: 1992 Credit points: 1.5 Date: 2009-03-16 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Medical Epidemiology and Biostatistics Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: - argue for the importance of ethical practice when using personal data in epidemiological research and identify ethical issues relevant to your own research. - document your research in a manner understandable by another researcher. - argue for the importance and benefits of structured procedures, such as data standards, for collecting and managing data in epidemiological studies. - archive a completed epidemiological research project according to KI guidelines and Swedish law. - apply the personal data act (Personuppgiftslagen (PUL)) and the legal responsibilities of researchers when using personal data in epidemiological research. - propose and implement appropriate IT-security procedures for your own research. Learning outcomes are classified according to Bloom¿s taxonomy: knowledge, comprehension, application, analysis, synthesis and evaluation. Contents of the course: The course covers legal and ethical aspects of using personal data in epidemiological research, including the personal data act (Personuppgiftslagen), definition of personal data, and legal roles and responsibilities of researchers in transferring and maintaining data. The course gives theory and practise of data collection and management, documentation, security, transfer, and archiving. The guidelines and standards developed and employed at the Department of Medical Epidemiology and Biostatistics (MEB) will be used as a case study throughout much of the course. MEB's data standard will be presented with discussion of the background and importance. The course will also present MEB's approach to using an analysis plan as a planning and documentation tool for data management and statistical analysis. A practical research project will be performed by the students, where they apply data management issues from planning to archiving. Type of teaching: Lectures, group discussions, computer sessions using Stata, case studies. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. Individual practical project together with a written reflection how the course content is relevent for the students' own research (past, present, or planned). Students who do not obtain a passing grade in the first examination will be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. Compulsory parts: 91 of 227
Only the examination is compulsory. Number of students: 15 - 25 Selection of students: 1.Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. To be considered, students are advised to submit a completed application form. Please, give all information requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: More information will be on our webpagehttp://ki.se/ki/jsp/polopoly.jsp?d=14380&a=40967&l=en - 25 Course responsible Therese Andersson Box 281 17177 Stockholm 08-524 861 38
[email protected] Department of Medical Epidemiology and Biostatistics Course contact Marie Dokken Box 281, 171 77 Stockholm Stockholm +46852482341
[email protected] Department of Medical Epidemiology and Biostatistics
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Titel: Avancerat seminarium i Tumörbiologi Kursnummer: 2000 Antal högskolepoäng: 3.0 Datum: 2009-01-13 - 2009-06-16 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för mikrobiologi, tumör- och cellbiologi Ingår i forskarutbildningspprogram Tumörbiologi-Onkologi Kursens lärandemål: Efter kursen skall doktoranden kunna diskutera och förstå avancerade cell- och tumörbiologiska frågeställningar som vanligen inte står att finna i läroböcker. De skall också kunna värdera och diskutera hur man löser problem, metodologiska tillvägagångssätt i forskningsfronten, även utanför sitt eget specifika kompetensområd. De skall framförallt kunna diskutera och värdera nya data inom dessa områden, men också få en up-to-date översikt över ämnet som ingen lärobok kan ge, pga ämnets snabba progress. Detta sker i seminarieform som leds av en nationell eller internationell forskare, samt en av lärarna ur kursledningen. Frågor och diskussion efter presentation av seminariehållaren. Kursens innehåll: Kursen kommer att belysa och diskutera forskningsfronten inom stora delar av ämnet tumörbiologi och experimentell onkologi. Ämnen som berörs är cellcykel, apoptosis, signaltransduktion, cancergenetik, epigenetik inkl histonreglering, cancerstamceller, proteomik inkl ubiquitin reglering, tumörimmunologi, infektioner och cancer, matematisk modellering, angiogenes, cell-cell communication, tumörers heterogenitet, vävnadsbiologi med anknytning till cancer, nya behandlingskoncept, samt problem inom klinisk cancerforskning. Arbetsformer: Föresläsningar och/eller seminarier i grupp med diskussion en gång/vecka. Föreläsningarna följs av diskussion med studenterna. Komplettering med litteraturstudier av forskningsartiklar. Omfattningen är ca 18 veckor med sammanlagt ca 20 seminarietillfällen, samt två-tre tillfällen i mindre grupp. Examination: Skriftlig examination i slutet av kursen i form av hemtentamen. Essayfrågor för att visa förståelse och mognadsgrad, samt enstaka kunskapsfrågor. Obligatoriska moment: Seminarierna är obligatoriska. Enstaka missade seminareitillfällen kan kompenseras på annat sätt efter diskussion med kursledaren. Intagning sker efter diskussion med kursledaren. Antal studenter: 10 - 20 Urval av studenter: Based on research area, motivation and need to take the course Ytterligare information: This course will provide an overview and discuss the cutting edge research frontier of large parts of tumor biology and experimental oncology. Subjects include cell cycle, apoptosis, signal transduction, cancer genetics, epigenetics, cancer stem cells, proteomics incl the ubiquitin-proteasome system, cell-cell communication, tumor heterogeneity, infections & cancer, tumor immunology, angiogenesis, mathematical modelling, new treatment concepts and problems in clinical cancer research. 93 of 227
Lectures and seminars with discussions once a week. Litterature studies (research articles) on some subjects connected to the seminars. Some top-scientits outside KI are invited as speakers. Appr 20 seminars, incl 2-3 occassions in smaller groups, Written home exam with essay questions at the end of the course. Most of the seminars are held at Tuesdays at 13.00 at MTC, KICampus. Ansvarig för kurstillfälle Ingemar Ernberg Karolinska Institutet, Box 280 171 Stockholm 08 524 862 62
[email protected] Institutionen för mikrobiologi, tumör- och cellbiologi
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Title: What is life? The future of biology. Course number: 2001 Credit points: 2.0 Date: 2009-01-25 - 2009-06-10 Språk: english Level: Forskarnivå Responsible department: Department of Microbiology, Tumor and Cell Biologi Included in postgraduate course programme: Tumour Biology and Oncology Learning outcomes: After the course students shall be able to discuss: 1. Theories about complexity of biological systems 2. How biocomplexity can be studied. 3. What is the place of computational simulations in modern biology? How simulations can be done? What the predictive power is. How mathematics can be used in simulating biological phernomena. 4. How one understands the organizational principles of biological systems. If self-organization is a field for study or just a trivial phenomenon. 5. How evolotionary theory can be formalized into mathematical models. 6. If quantum mechanical theory can have a role in molecular biology. 7. How genetic information can be converted to mechanical or electrical force in biological system. The students will also aquire an understanding of the conceptual and technical challenges in future biomedicine and advance your ability to ask scientific questions and identify significant - and possible - areas for problem solving. Contents of the course: Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years ago we will adress this question again, in view of the impressive development since then. There are many new concepts to consider in the future of biology, such as the consequencies of the -omics era, complexity, computation and simulation, as well as the role of mathematicss and physics in biological theory. The course will cover areas such as biocomplexity, quantum mechanical theory in biology, computation and simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry become electric and magnetic forces and evolutionary theory in the light of molecular biology. Leading scientists with an overview perspective will be invited to discuss in the seminar form the challenges that meet us today in biology, as a result of the --omics era, the availability of large amounts of data as a result of high through-put techniques, and the possibilities provided by mathematics, simulation theory and computational biology. Young scientists in this areas are also invited to lecture from their perspective. Invited experts will review these areas in lectures. They will also meet the students for an additional two hours in a workshop discussion of basic concepts. Type of teaching: Two seminars+worskhop every month for five months, 2,5-3 hrs on each occassion. Every occasion consists of a appr 1-2 hour seminar/lecture with the invited expert followed by a two hour open discussion, i.e 3-4 hours on each occassion. For each seminar the students will usually be given at least one article on the topic to read. Active participation in discussions in groups with invited speaker of high international standards is a key element. You also receive DVD-recordings of all lectures for further self studies at home. Examination: Continuous by workshop discussions. Written home-exam (essay). Compulsory parts: The seminars are compulsory. Absence can be compensated for after discussion with the course leader. 95 of 227
Number of students: 10 - 25 Selection of students: Based on motivation, need to take the course and on area of research More detailed information: This course will cover 1. Theories about complexity of biological systems 2. How can biocomplexity be studied? 3. What is the place of computational simulations in modern biology? How can simulations be done? What is the predictive power? How can mathematics be used in simulating biological phernomena? 4. How can one understand the organizational principles of biological systems? Is Self-organization a field for study or just a trivial phenomenon? 5. Can evolotionary theory been formalized into mathematical models? 6. Does quantum mechanical theory have a role in molecular biology? 7. How can genetic information be converted to mechanical or electrical force in biological systems? Active participation in discussions in groups with invited speaker of high international standards is a key element. Students also receive DVD-recordings of all lectures for further self studies at home. Two teaching occassions/month, 15.00 - 18.00 including discussion with students. The lectures and discussions are held at KI campus. - 25 Course responsible Ingemar Ernberg Karolinska Institutet, Box 280 171 Stockholm 08 524 862 62
[email protected] Department of Microbiology, Tumor and Cell Biologi Course contact Lars Helin Board of Cultural Affairs 171 stockholm 08/52486585
[email protected] Department of Microbiology, Tumor and Cell Biologi
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Title: Problem based overview of medicial statistics Course number: 2026 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: After the course the students should have improved their understanding of the statistical methods frequently used in medicine, and be able to communicate with statisticians, though not be able to perform statistical analyses by themselves. Contents of the course: Basic overview of medical statistics: basic statistical terms, randomized trials, cross-sectional studies, casecontrol studies, prospective studies, basic epidemiology, confounding, mediation, interaction, biases Type of teaching: Inför varje dag kommer en eller två artiklar att användas som diskussionmaterial - studenterna förväntas ha läst dessa (tid för inläsning finns dagen innan på em). Dagen börjar alltid med "dagens QUIZ" rekapitulering av gårdagen i diskussionsform Övergripande föreläsningar, interaktiva gruppdiskussioner utifrån kurslitteratur, sammanfattande föreläsningar vid dagens slut. I princip följer varje dag de statistiska modeller och begrepp som diskuteras i respektive artikel. Examination: Examinationen består av två faktiska abstract från vetenskapliga artiklar där studenterna skall besvara ett antal frågor för varje abstract. Open book. Compulsory parts: Number of students: 18 - 30 Selection of students: Health professionals in clinical work with no or limited statistical knowledge will be given priority More detailed information: - 30 Course responsible Imre Janszky 5th floor, Norrbacka 17176 Karolinska sjukhuset +4687373894
[email protected] Department of Public Health Sciences Course contact Rickard Ljung 2nd Floor Norrbacka 171 Stockholm 075-2473307
[email protected] Department of Public Health Sciences 97 of 227
Title: Neuropschopharmacology of Affective Disorders Course number: 2033 Credit points: 1.5 Date: 2009-03-30 - 2009-04-03 Språk: english Level: Forskarnivå Responsible department: Department of Physiology and Pharmacology Included in postgraduate course programme: The Neurosciences Learning outcomes: The PhD students will achieve a better understanding of the etiology of affective disorders and how these diseases are treated. Contents of the course: This course will focus on pharmacological strategies in the streatment of affective disorders, e.g. major depression. The course will also discuss methods and models which are used in preclinical research concerning the mechanisms of action of different drugs in the treatment of these disorders. Type of teaching: The pedagogic framing of the course include lectures given by invited clinicians and researchers within the field of affective disorders. We will also have demonstrations of key models/methods which are used in specific research projects. Examination: Written exam Compulsory parts: The demonstrations are compulsatory. The student has to compensate absense from this part with a written description of the model/method. Number of students: 10 - 30 Selection of students: Priority will be given to registered PhD student, active within the research field of Affective disorders More detailed information: The course will be given in english - 30 Course responsible Kent Jardemark 17177 Stockholm 08-52487918
[email protected] Department of Physiology and Pharmacology Course contact Per Svenningsson 17177 Stockholm 08-52487918
[email protected] Department of Physiology and Pharmacology
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Title: Pathology Course number: 2044 Credit points: 3.0 Date: 2009-05-04 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Laboratory Medicine Learning outcomes: After the course the student has knowledge on principles of growth and differentiation of cells and tissues, how cells adapt to local environment and react to and cope with stress, injury and inflammation. Mechanisms of repair and cellular ageing will be illustrated. The student will have knowledge of genetic events underlying some human cancers and experimental tumor models. The student will be able to compare advantages and limitations of different methods for cell and tissue analyses including microscopy. Contents of the course: The course is divided into two parts. The first part illustrates cell injury, adaptation and inflammation. Mechanisms of oxidative stress, cellular defence and ageing will be discussed as well as new methods in cellular and molecular pathology. During the second part of the course will focus on tumor development and malignancy. We will discuss how basic pathological responses to inflammation or injury might be the first steps on a multi-step path to malignancy. Type of teaching: This is a full time course with lectures, seminars, demonstrations and microscopy exercises. Examination: Written examination. Compulsory parts: All demonstrations are compulsory. Absence must be compensated with a written report about the subject of the demonstration. Number of students: 12 - 18 Selection of students: In relation to the time the applicant has been a registered PhD student More detailed information: - 18 Course responsible Anna-Klara Rundlöf F46, Karolinska Universitetssjukhuset Huddinge 14186 Stockholm +46858582926
[email protected] Pathology Department of Laboratory Medicine Course contact Anna-Klara Rundlöf F46, Karolinska Universitetssjukhuset Huddinge 14186 Stockholm +46858582926 99 of 227
[email protected] Pathology Department of Laboratory Medicine
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Title: Innovation and Technology Management Course number: 2059 Credit points: 4.5 Date: 2009-02-01 - 2009-05-31 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: After the course, the students should be able to place their own research in a broader context with regard to commercialization options and benefits from a societal point of view. The student will also have a better understanding of the theoretical framework and increased know-how about the actors in the innovation system. Contents of the course: A broad introduction to innovation management and new perspectives and inspiration related to their own research, with insight in the commercialization process and legal backgrounds as well as with theoretical knowledge and practical tools on how to develop innovations. Type of teaching: The course will run on a part-time basis, once a week, in the late afternoon/evening and consist of six to eight 3hour session with mandatory lectures and a case workshop (approx 50 hrs). The lectures will evolve around different aspects, strategies and tools related to innovation and technology development and management. Apart from literature studies (approx. 40 hrs), students are required to keep a learning log relating the studied material to their own field of research (30 hrs). Examination: Class participation, learning log on lecture content and reading assignments and work on a group case. Compulsory parts: Absence from one compulsory lecture can be approved by the course direction if a hand-in of the topic in question is written based on the course literature and discussions with fellow students and teachers. Number of students: 15 - 35 Selection of students: Selection is based on registration date. More detailed information: Kontaktperson för kurs 2059 är: Claudia Hakanen SSES Box 6501, 113 83 Stockholm Telefon: 08-736 15 87 Mailadress:
[email protected] - 35 Course responsible Carl Johan Sundberg Berzelius väg 13 Stockholm
[email protected] Department of Physiology and Pharmacology
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Title: Frontiers in leadership research Course number: 2068 Credit points: 7.5 Date: 2009-02-24 - 2009-05-12 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: To provide the students with an opportunity to discover how leadership research is of relevance for their research questions and how knowledge from this area can further illuminate their field of research. One purpose is to offer the students a broad network of research associates, senior colleagues and teachers with different research perspectives. After the course the students should be able to distinguish between leadership research and social sciences in general and between contemporary as well as historical paradigms and to apply knowledge from leadership research in their own research. They should be able to identify when leadership issues must be taken into consideration in research on work environment, quality improvement, work health and organisational efficiency and profitability et cetera. Contents of the course: The lectures are organized according to this structure: - Introduction; sketching out the field of leadership research, aspects of leadership in research and theory, current issues and debates - History of leadership research - Contemporary leadership theories - Leadership theories applied in public organisations and business - Examination and discussion of students essays The course is a cooperation between Stockholm School of Economics, Centre for Advanced Studies of Leadership (Dr Mats Tyrstrup), The Swedish Defence College, Department of Leadership (Professor Gerry Larsson), The Swedish School of Sports and Health Sciences (Professor Mats Ericson) and Karolinska Institutet, Medical Management Centre (Associate Professor Christer Sandahl). Type of teaching: The course runs part-time and is held on daytime. Lectures, seminars and group work are scheduled once weekly during three months. Own work includes literature studies and essay writing. Distance learning is possible, assuming that the student has access to the technical equipment needed to participate via video conferencing. Examination: The course will be examined in the form of a written term paper in which the students relate the course literature to their own research. This paper will also be presented and discussed in connection to the termination of the course. This type of examination is suitable for the aim of the course with individual outcomes dependent on the students-- background and research perspective. Compulsory parts: Active participation in the seminars which are compulsory. Absences from those activities will have to be made up with written examinations. Number of students: 10 - 20 Selection of students: The students will be selected firstly by motivation and secondly by time from registration as PhD student More detailed information: 102 of 227
10.00-16.00 24 Feb. 15.00-17.30 3/3, 10/3, 17/3, 24/3, 31/3 and 28/4. 09.00-17.00 12/5. - 20 Course responsible Christer Sandahl Karolinska Institutet 171 Stockholm 08-524 836 18
[email protected] Department for Clinical Science, Intervention and Technology Course contact Therese Wahlström Karolinska Institutet 08-524 836 84
[email protected] Department for Clinical Science, Intervention and Technology
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Title: Qualitative Research Methods Course number: 2076 Credit points: 4.5 Date: 2009-03-02 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: At the end of the course the students should be able to: - understand and explain the theoretical basis for the main qualitative methods used in public health research - understand and explain the main differences between qualitative and quantitave research - know the main qualitative research methods used in public health research (content analysis, phenomenography, grounded theory, narrative analysis), understand the differences between them and know how to choose the method most adequate for the research question at hand - plan and carry out a qualitative research interview, a focus group discussion and an observation session, including know how to handle the information gathered and analyse the data - understand the ethical aspects of qualitative research and how to handle them in a professional way - explain how the validity/quality is assessed in qualitative research - plan and carry out a qualitative study - prepare the outline of an article based on data collected during the course Contents of the course: - Theoreticl basis for qualitative research - The main qualitative research methods in public health research( participant selection, data collection, handling of data, analysis) - Validity/quality assessment of qualitative resarch - Ethics in qualitative resarch - Reading and writing qualitative research Type of teaching: - Lectures - Group work - Practising observations, interviewing and moderating focus group discussions - Practising handling of qualitative data by hand and using software - Practising how to analyse qualitative data and writing it up - Seminars to discuss the experiences from the practical sessions Examination: - an individual written examination to assess aquired knowledge and understanding of qualitative research - assessment of the practical assignments and how the experiences are presented in the seminars - the drafts for an article based on the data collected in the practical assignments to assess the understanding of the process and ability to analyse data and condense information Compulsory parts: All practical assignments are compulsory and should to be carried out during the course. If a student is absent compensation should be agreed on with the courseleader and if possible finalised during the course period. Number of students: 15 - 15 Selection of students: Priority will be given to KI-registered students involved in qualitative research in public health sciences with a 104 of 227
focus on Global health if many applicants and according to time of application. More detailed information: The course is given at Karolinska institutet, Solna Campus. A theoretical basis is given, but the main focus is on how to handle data colloction and analysis practically. Students are invited to bring their own data if they have interviews they want to work with. - 15 Course responsible Birgitta Rubenson 171 Stockholm +(46) 8 52483389
[email protected] Department of Public Health Sciences Course contact Helena Faxelid Karolinska Institutet 17177 Stockholm +(46) 8 52483389
[email protected] Department of Public Health Sciences
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Title: Diseases in Man Course number: 2084 Credit points: 3.0 Date: 2009-01-19 - 2009-01-30 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Learning outcomes: To understand diagnostic criteria of disease; to understand pathophysiological processes and their treatment. Contents of the course: To give a deeper understanding of different kinds of diseases that may occur in humans, both within surgery and medicine. Type of teaching: Lectures on common diseases in man, their diagnosis and treatment according to principles of evidence-based medicine given for 2 weeks (full days), plus a seminar presentation of a specific forefront topic of today's medicine, which may include parts of the student's own research subject. Lectures are given according to a 6-8 lectures per day schedule, while group work is done outside scheduled study time and considered to be openly presented as scheduled before the final examination. Examination: Written test, short answers Compulsory parts: Seminar presentations and examination are compulsury. Compensation for absence will be discussed with the course leader. Number of students: 8 - 20 Selection of students: Date of PhD registration More detailed information: 2 weeks with full time schedule - 20 Course responsible Per Hellström Karolinska Solna A3:00 Stockholm +46851773877
[email protected] Department of Medicine, Solna Course contact Linda Gillberg Gastroforskn lab M1:02 Stockholm +46851772289
[email protected] Department of Medicine, Solna
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Title: How genes meet environment: genetics of human complex diseases Course number: 2104 Credit points: 3.0 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Learning outcomes: The aim of the course is to facilitate understanding the pathogenesis of human complex diseases and of modern approaches for genetic studies of human complex diseases. Intended learning outcomes will be: 1.To be able to discuss and differentiate between Mendelian and complex genetic diseases 2.To define phenotypic characteristics of major common human complex diseases 3.To know how to use major genetic databases for research purposes 4.To be able to design a genetic study of human complex diseases 5.To understand and to evaluate gene-gene and gene-environment interactions in a study of human complex diseases 6.To apply modern statistical methodology in study of complex diseases. Contents of the course: Biological/clinical description of human complex diseases Introduction in molecular genetics of human complex diseases Introduction in genetic epidemiology of human complex diseases Methodological approaches and bioinformatics Type of teaching: Lectures, seminars, lab demonstrations, small group projects, IT-use Examination: Project presentation, group discussion Compulsory parts: Number of students: 10 - 25 Selection of students: Relation for PhD project More detailed information: The speakers will be invited from leading Swedish and international groups working with genetics of complex diseases. The course will take place at CMM, Karolinska Hospital - 25 Course responsible Leonid Padyukov CMM L8:O4 KS Solna 08-51776560
[email protected] 107 of 227
Department of Medicine, Solna Course contact maria Seddighzadeh CMM L8:O4 KS Solna 08-51776554
[email protected] Department of Medicine, Huddinge
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Title: Introduction to medical anthropology Course number: 2111 Credit points: 4.0 Date: 2009-02-09 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Learning outcomes: The expected learning outcomes of the course are that students will be able to: - Understand the way culture shapes concepts of health, expectations of care, and patterns of social interaction that affect the meeting between health care providers and their patients. - Analyse fundamental social and cultural factors that influence the provision of health care and adherence to care regimens - Apply cultural understandings of the body, health, illness and family relationships in both research and clinical settings - Explain the cultural assumptions of Western biomedicine Contents of the course: The course will take up the following topics: - The concept of culture - Qualitative research methods for cultural research - Crosscultural concepts of the body, health, illness, and family - Cultural assumptions of Western biomedicine Type of teaching: Lectures and seminars Examination: Class participation, written paper and presentation Compulsory parts: Attendance at 4 lectures and 4 seminars is obligatory. Missed seminars are to be made up with written assignments. Number of students: 10 - 25 Selection of students: Relevance of research project and stated motivation for taking the course More detailed information: The course consists of lectures and seminars and focuses on the importance of sociocultural factors in medical, public health and nursing research as well as clinical practice. - 25 Course responsible Rebecca Popenoe Alfred Nobels allé 23 Huddinge 08-524 83 924 , 070 284 4263
[email protected] Div. of Nursing Department of Neurobiology, Care Sciences and Society Course contact 109 of 227
Rebecca Popenoe Alfred Nobels allé 23 Huddinge 08-524 83 924 , 070 284 4263
[email protected] Div. of Nursing Department of Neurobiology, Care Sciences and Society
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Title: Mucosal immunity and infections Course number: 2113 Credit points: 1.5 Date: 2009-03-02 - 2009-03-06 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Included in postgraduate course programme: Infection Biology Learning outcomes: Mucosal immunity and infections. Contents of the course: The content of the course may be divided into two parts: Part I This part provides an introductory overview on the physiology of the mucosal defense in the genital and gastrointestinal tracts. More specifically, we will address the structure and function of the mucosal epithelium in different compartments and different cell types including cellular basis of antigen transport, innate immune factors, development and function of mucosal immunoglobulin. We will also address the different target and effector sites for the mucosal immune responses. Part II In this part of the course, we will address the secretory immune system with special reference to mucosal infections and diseases. We will specifically focus on bacterial and viral infections in the genital tract and the corresponding mucosal immune responses. Finally, we will discuss and explore the field of mucosal immunization and the concepts of mucosal vaccines. Type of teaching: The course will consist of lectures given by researchers within the field of the course. There will be external (outside KI) and internal speakers. There will also be a group assignment. For the group assignment computer space will be provided. Examination: Both written and oral. The students will be examined on their group assignment by handing in a written report individually as well as presenting their group assignment orally for the other course members. Compulsory parts: The students are expected to attend all the lectures and seminars held within the course. Also, they are expected to actively participate in the group assignment and presentation plus hand in the written report to successfully complete the course. Single missed sessions may be replaced by written tasks adapted to the situation. Number of students: 12 - 25 Selection of students: Registered PhD students from KI with projects and an interest within the scientific field of the course. More detailed information: The content of the course may be divided into two parts: Part I This part provides an introductory overview on the physiology of the mucosal defense in the genital and gastro intestinal tracts. More specifically, we will address the structure and function of the mucosal epithelium in different compartments and different cell types including cellular basis of antigen transport, innate immune factors, development and function of mucosal immunoglobulin. We will also address the different target and effector sites for the mucosal immune responses. 111 of 227
Part II In this part of the course, we will address the secretory immune system with special reference to mucosal infections and diseases. We will specifically focus on bacterial and viral infections in the genital tract and the corresponding mucosal immune responses. Finally, we will discuss and explore the field of mucosal immunization and the concepts of mucosal vaccines. The course will consist of lectures given by both international and national researchers within the field. There will also be a group assignment at the end of the course. - 25 Course responsible Karin Loré Center for Infectious Medicine, F59, 4572652
[email protected] Department of Medicine, Huddinge Course contact Taha Hirbod Center for Molecular Medicine 51776731
[email protected] Department of Medicine, Solna
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Title: Obesity in man: metabolic and clinical aspects Course number: 2126 Credit points: 1.5 Date: 2009-04-20 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Included in postgraduate course programme: Metabolism and Endocrinology Learning outcomes: After completing the course the student shall understand the development of human obesity, its impact on metabolic functions and pathophysiology in the clinical setting. Contents of the course: Lectures of obesity in man, effects on metabolism, approach to treatment according to principles of evidencebased medicine and knowledge of obesity, its impact on human life, and complicating diseases and disorders, as well as treatment of today and tomorrow. Type of teaching: Lectures are scheduled according to 6-8 lectures per day, while group work is done outside scheduled study time and considered to be openly presented at scheduled seminars before the final examination. Examination: Written examination Compulsory parts: Seminar presentations, examination. Absence must be discussed with course leader. Number of students: 15 - 20 Selection of students: datum för doktorandregistrering More detailed information: - 20 Course responsible Per Hellström Karolinska Solna A3:00 Stockholm +46851773877
[email protected] Department of Medicine, Solna Course contact Wiveka Ring-Persson M1:02 08-51772289
[email protected] Department of Medicine, Solna
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Title: Introduction to Knowledge Translation and Implementation Science Course number: 2130 Credit points: 3.0 Date: 2009-01-27 - 2009-03-02 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Included in postgraduate course programme: Health Care Sciences Learning outcomes: 1. have a basic understanding of the nature of the field of knowledge translation and implementation science 2. be able to identify some conceptual and methodological challenges in the field of knowledge translation 3. be able to make preliminary analyses of the forces influencing the use of knowledge in practice and evidence-based decision-making Contents of the course: This course comprises an introduction to the scientific and theoretical field of knowledge translation and implementation science. Attention is given to contemporary manifestations in Swedish health care such as evidence based medicine and evidence-based practice. Particular attention will be given to the challenges facing knowledge use in complex organizations. The course will introduce the central conceptual and methodological challenges facing investigators undertaking knowledge translation research. Type of teaching: This course is offered in weekly seminar format building on students reading and discussions of the course literature. Seminars will be held over 4 weeks. Examination: The students-- knowledge, skills and professional attitudes will be assessed in two ways: (1) Course participation where individual activity and contribution to seminars are assessed (2) A poster presentation where knowledge translation theory is presented for decision-makers Compulsory parts: All seminars are compulsory. Absence is compensated through a written summary of the literature for the seminar where absence occurred. Number of students: 15 - 20 Selection of students: Priority will be given to postgraduate students based on the written motivation. More detailed information: The course is given at Eugeniahemmet and consists of 4 litterature seminars and one examination seminar. The course litterature is based on articals within the reasearch area. - 20 Course responsible Lars Wallin Eugeniahemmet T4:02, KS 17176 Solna +46-8-517 754 54
[email protected] 114 of 227
Department of Neurobiology, Care Sciences and Society Course contact Lars Wallin Eugeniahemmet T4:02, KS 17176 Solna +46-8-517 754 54
[email protected] Department of Neurobiology, Care Sciences and Society
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Title: Research methods in economic evaluation of public health interventions Course number: 2131 Credit points: 1.5 Date: 2009-02-09 - 2009-02-13 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: After the course, the student should: - understand basic economic views and theories applicable to public health - be able to motivate the use of different methods for economic evaluations - know how to calculate costs and savings typical for public health interventions - know how to calculate health gains by quality-adjusted life years (QALYs) - understand the basic procedure for modelling in health economic evaluation - be capable of ethical reflections regarding public health economics Contents of the course: - Introduction to economic views and theories applicable to public health - Overview of public health interventions; community based vs individual strategies - Methods for economic evaluation; cost-effectiveness analysis vs cost-benefit analysis - Measurements of costs and savings of particular public health relevance - Measurements of health gains: from risk factor and HRQoL to QALYs - Practical experience on how to carry out an economic evaluation - Introduction to modelling in health economic - Clarification of fundamental ethical principles in public health economics Type of teaching: Lectures, Group work, Discussions Examination: Written examination, Group work presentation Compulsory parts: Number of students: 12 - 25 Selection of students: Date of application. More detailed information: - 25 Course responsible Anna Månsdotter Norrbacka plan 7 17176 Stockholm +46 (0)8 737 39 61
[email protected] Department of Public Health Sciences 116 of 227
Titel: Mer om datahantering och data analys med SPSSsyntax Kursnummer: 2134 Antal högskolepoäng: 3.0 Datum: 2009-03-05 - 2009-03-24 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för neurobiologi, vårdvetenskap och samhälle Ingår i forskarutbildningspprogram Vård och Omsorg Kursens lärandemål: Efter genomgången kurs ska doktoranderna kunna skriva och hantera SPSS-syntax för att modifiera statistiska datamängder. Mer precist ska de kunna förstå och använda bl.a. följande kommandon (inklu¬sive olika subkommandon): Compute, Recode, If, Select if, Do-if-else, Filter, Sample, Variable labels, Value labels, Add value labels, Formats, Missing values, Sysmis, $Sysmis, List, Show, Set, Trunc, Mod, Crosstabs, Means, Examine, Frequencies, Yrmoda, File handle, Get file, Save outfile. De ska även lära sig att läsa de felmeddelanden som regelmässigt dyker upp i resultatfönstret och rätta sin syntax ("debugging"). Dessutom ska de kunna använda sig av Syntaxmanualen och andra hjälpfunktioner i SPSS. Kursens innehåll: Under kursen behandlas bl.a. kommandon för att definiera, beskriva, modifiera, selektera och analysera data. Kursen inleds med en övergripande genomgång av hur syntax kan genereras, sparas och användas och hur grundläggande variabelkommandon kan utföras med syntax, vilket exemplifieras genom demonstrationer på för alla tillgängliga data. Genom strukturerade uppgifter får doktoranden pröva olika tekniker. Kursen fortsätter med att deltagarna själva arbetar med olika övningsuppgifter under handledning, bl.a. sker en fördjupning i syntaxmetodik med inriktning på urvals- och selektionsprocedurer, liksom på bortfallshantering. I kursen demonstreras även hur olika funktioner i excel och word kan användas för att generera och manipulera syntax på ett "kreativt" sätt för att öka och effektivisera den egna kontrollen av data. Avslutningsvis diskuteras olika arbetssätt för att dokumentera datakontroller, datamodifikationer och nybildning av variabler genomförda med syntax (för att möjliggöra återbruk, förbättring och kommunikation av syntax) i bl.a. SPSS, excel och word. Data från bl.a. Levnadsnivåundersökningen (Institutet för Social Forskning) används i kursens demonstrationer och övningsuppgifter. Arbetsformer: Kursen omfattar totalt två veckors heltidsstudier, dels i datasal (undervisning och handledda övningar med diskussion) och dels förutsätts studenterna arbeta aktivt med kursmaterialet under hela kursperioden. Viss individuell handledning kommer även att kunna förmedlas via t.ex. e-post mellan kursdagarna. Examination: Kursen avslutas med ett seminarium där studenternas loggböcker (en dokumentation av lärprocessen) och examinationsuppgifter (som ska visa på förmågan att använda sig av SPSS-syntax) redovisas och diskuteras. Examinationsuppgiften kan t.ex. baseras på de data som används i kursen (eller på doktorandens egna data). Obligatoriska moment: Vid frånvaro från datasalsundervisning/-övning får doktoranden göra kompletterande övningsuppgift/-er. Antal studenter: 8 - 10 Urval av studenter: 117 of 227
Doktorander knutna till Forskarskolan Vård och Omsorg, KI och samverkande högskolor har företräde, men i mån av plats får andra doktorander delta i kursen. Ytterligare information: Kursen ges i Västerås (5/3, 10/3, 12/3 och 24/3 kl. 10-15). Kursspråk svenska. Ansvarig för kurstillfälle Göran Sidebäck Mälardalens högskola, Box 883 72133 Västerås 46021107006
[email protected] Arbetsterapi Institutionen för neurobiologi, vårdvetenskap och samhälle Kontaktperson för kurstillfälle Göran Sidebäck Mälardalens högskola, Box 883 72133 Västerås 46021107006
[email protected] Arbetsterapi Institutionen för neurobiologi, vårdvetenskap och samhälle
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Titel: Medicinsk vetenskapsteori och forskningsetik * Kursnummer: 2137 Antal högskolepoäng: 1.5 Datum: 2009-03-23 - 2009-03-27 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för neurobiologi, vårdvetenskap och samhälle Kursens lärandemål: Efter kursen förväntas deltagarna kunna - förstå den filosofiska och praktiska bakgrunden till nuvarande system för granskning av etik i medicinsk forskning - självständigt skriva en ansökan till regional etikprövningsnämnd inklusive en korrekt information till forskningspersoner - förklara betydelsen av och relationen mellan ett antal specificerade vetenskapsteoretiska begrepp - reflektera över vilken betydelse dessa begrepp har för förståelsen av olika forskningsmetoder och kunna relatera dem till den egna forskningen Kursens innehåll: Forskningsetik: - Viktiga basbegrepp - Forskningsetikens historia och utveckling - Etiska problem när det gäller forskningspersoner - Information till forskningspersoner - Forskningsetiska nämnder och PUL - Genomgång av etikkurs från NIH school of ethics (interaktiv on-linekurs från National Institutes of Health, USA) Vetenskapsteori: - Vetenskapsteoriens historia - Olika teoretiska ståndpunkter inom ontologi och kunskapsteori - Induktion, deduktion, falsifikation, hypotetisk-deduktiv metod - Paradigm - Vetenskapliga förklaringar Forskningsetik och vetenskapsteori gemensamt: - Pseudoforskning Arbetsformer: Orienterande föreläsningar Grupparbeten kring olika typer av fallbeskrivningar (storgrupp, smågrupper, bikupor) Olika former av återkoppling och repetition av materialet (kvarvarande funderingar, reflektioner från föregående dag, etc) Etikkurs on-line från NIH (National Institutes of Health) Litteraturstudier Resurspersoner: Kursledningen, inbjudna experter och praktiskt verksamma forskare Examination: Kursdeltagarna ska lämna in en uppgift senast två veckor efter kursens slut. Inlämningsuppgiften kommer att utgå från en forskningsplan och kommer att bestå i att dels skriva en korrekt information till forskningspersonerna, dels diskutera ett antal vetenskapsteoretiska problemställningar. Obligatoriska moment: Samtliga delar är obligatoriska. Frånvaro kompenseras genom extra inlämningsuppgift avseende den del av 119 of 227
kursen som frånvaron gäller. Antal studenter: 20 - 25 Urval av studenter: Motivation för deltagande. Kliniskt inriktade projekt. OBS: Obligatoriskt att vid ansökan skicka med en kort beskrivning av det egna projektet (5 rader). Ytterligare information: Kursen ges i Centrum för Allmänmedicins lokaler, Campus Huddinge. Ansvarig för kurstillfälle Ylva Skånér Alfred Nobels allé 12 141 Huddinge 070-484 22 06
[email protected] CeFAM Institutionen för neurobiologi, vårdvetenskap och samhälle Kontaktperson för kurstillfälle Ylva Skånér Alfred Nobels allé 12 141 Huddinge 070-484 22 06
[email protected] CeFAM Institutionen för neurobiologi, vårdvetenskap och samhälle
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Title: To communicate science in different contexts Course number: 2144 Credit points: 3.0 Date: 2009-04-07 - 2009-05-20 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: After the course the student is expected to be able to: 1. Reflect on and develop your oral communication skills, describing your own research based on experience, feedback and theories in communication and learning. 2. Orally present a main message from own research to a scientific audience and a general public. Contents of the course: During the course each participant will be given the opportunity to develop practical and theoretical knowledge in: -- Communication and learning -- Presentation techniques -- Rhetoric -- Use of different media (such as Posters, Overhead-projector, PowerPoint, Whiteboard) Each course participant will give three oral presentations, after which there will be feedback on content, communication skills and use of media. Type of teaching: The course contains lectures, interactive lectures, group sessions and sessions for PP at computer terminals as well as self-directed learning. Examination: The course assessment is based on reflective practice and will be made in four different parts: 1. Oral presentation in a popular science context (video recorded). 2. Oral presentation in a scientific context (departmental lab-meeting or equivalent). 3. Reflective statement based on theories of communication and learning. 4. Oral presentation in a popular science context supported by PowerPoint. Compulsory parts: Compulsory moments in addition to 75% presence: 1. Oral presentation in a popular science context (video recorded) (day 3 or 4 of the course). 2. Oral presentation in a scientific context (departmental lab-meeting or clinical meeting, outside course schedule between day 4 and 5 of the course). 3. Written reflective statement based on theories of learning and understanding has to be handed in. 4. Oral presentation in a popular science context supported by PowerPoint (day 5 or 6 of the course) Absence from the group sessions with own presentations can be compensated by extra arranged sessions, which have been scheduled beforehand, or participation of that session during the next course. Absence from lectures can be compensated by reading literature provided by the lecturer. Number of students: 20 - 40 Selection of students: According to registration date as PhD student at KI More detailed information: The course is a two week course which requires time for independent work outside of scheduled class time. 121 of 227
Scheduled class room sessions are on the following dates: 7-8/4, 29-30/4, 19-20/5. - 40 Course contact Ingrid Smedberg Berzelius väg 3 171 Stockholm 524 837 89
[email protected] Department of Learning, Informatics, Management and Ethics
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Titel: Att kommunicera vetenskap i olika sammanhang * Kursnummer: 2145 Antal högskolepoäng: 3.0 Datum: 2009-01-22 - 2009-02-19 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för lärande, informatik, management och etik Kursens lärandemål: Efter denna kurs ska studenten -- Reflektera över och utveckla sin muntliga kommunikation av den egna forskningen utifrån erfarenhet, konstruktiv återkoppling och teorier om kommunikation och lärande. -- Muntligt framföra ett huvudbudskap från den egna forskningen till forskarkollegor samt en intresserad allmänhet. Kursens innehåll: Under kursen ges du möjlighet att utveckla praktisk och teoretisk kunskap om: -- Kommunikation och lärande -- Presentationsteknik -- Retorik -- Användande av olika hjälpmedel (dvs. Poster, Overhead, PowerPoint, White-Board) Varje kursdeltagare utför under kursen tre muntliga presentationer som följs upp med återkoppling på innehåll, kommunikationsförmåga och användande av hjälpmedel. Arbetsformer: Kursen innehåller föreläsningar, interaktiva föreläsningar, gruppsessioner och sessioner för Powerpoint vid egen dataterminal såväl som eget arbete. Examination: Examinationen är baserad på reflekterande praktik och är indelad i fyra olika delar: 1. Muntlig presentation i ett populärvetenskapligt sammanhang (videoinspelning) 2. Muntlig presentation i ett vetenskapligt sammanhang (labmöte eller liknande vid egna institutionen) 3. Skriftlig reflektion baserad på teorier om kommunikation och lärande 4. Muntlig presentation i ett populärvetenskapligt sammanhang med stöd av PowerPoint Obligatoriska moment: Obligatoriska moment: 1. Muntlig presentation i ett populärvetenskapligt sammanhang (videoinspelning) (dag 3 eller 4 under kursen). 2. Muntlig presentation i ett vetenskapligt sammanhang (labmöte eller liknande vid den egna institutionen, sker på ej schemalagd tid mellan dag 4 och 5 under kursen). 2. Skriftlig reflektion baserad på teorier om kommunikation och lärande ska lämnas in. 3. Muntlig presentation i ett populärvetenskapligt sammanhang med stöd av PowerPoint (dag 5 eller 6 under kursen) Om man missar en av gruppsessionerna erbjuds extrasessioner, som är shemalagda från början, eller delta i en senare kurs. Om man missar föreläsningar, kan de antingen tas igen i senare kurs eller genom att läsa literatur som tillhandahålls av föreläsaren. Antal studenter: 20 - 40 Urval av studenter: 123 of 227
According to registration date as PhD student at KI Ytterligare information: The course is a two week course which requires time for independent work outside of scheduled class time. Scheduled class room sessions are on the following dates: 22-23/1, 4-5/2, 18-19/2. Kontaktperson för kurstillfälle Ingrid Smedberg Berzelius väg 3 171 Stockholm 524 837 89
[email protected] Institutionen för lärande, informatik, management och etik
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Title: To communicate science in different contexts Course number: 2146 Credit points: 3.0 Date: 2009-04-27 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: After the course the student is expected to be able to: 1. Orally present own research adapted to different target groups. 2. Reflect on presentation skills and ability to adapt to different target groups. Contents of the course: During the course each participant will be given the opportunity to develop practical and theoretical knowledge in: ¿ Communication, perception and learning ¿ Presentation techniques ¿ Rhetoric ¿ Use of different media (such as Posters, Overhead-projector, PowerPoint, Whiteboard) Each course participant will perform three oral presentations and receive feedback on content, presentation skills and adaptation towards target group. Type of teaching: The course design is based on reflective practice and includes self-directed learning, lectures and literature seminar to process theoretical knowledge, and practical training in presentation skills Examination: The assessment consists of two different tasks: 1. Reflective statement based on experience, feedback and research/ literature within communication and learning. 2. Oral presentation in a popular scientific context supported by PowerPoint. To pass the course the participant needs show evidence that they reached the learning outcomes by fulfillment of the assessment criteria. Compulsory parts: Compulsory sessions are: 1. Oral presentation in a popular scientific context (video recorded) (day 3 or 4 of the course). 2. Oral presentation in a scientific context and observe and give feedback to an oral presentation made by a peer (outside scheduled classtime). Absence from the compulsory sessions or assessment seminar can be compensated by participating in corresponding sessions during the next course. Number of students: 20 - 40 Selection of students: According to registration date as PhD student at KI More detailed information: The course is a two week course which requires time for independent work outside of scheduled class time. Scheduled class room sessions are on the following dates: 27-28/4, 6-7/5, 28-29/5. - 40 Course contact 125 of 227
Ingrid Smedberg Berzelius väg 3 171 Stockholm 524 837 89
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Methods and Ethics in intercultural resarch with children Course number: 2148 Credit points: 1.5 Date: 2009-04-20 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: At the end of the course the students should: - know and describe the concept of childhood and its development and variation - know the main aspects of children's rights and understand how it affects the involvement of children in research - be familiar with methods to enhance children's participation in research - know, understand and discuss ethical considerations when involving children in research Contents of the course: - Concepts of childhood historically and interculturally - The convention on the rights of the child - Methods for children's participation in research - Informed consent from minors, ethical considerations when involving minors Type of teaching: Lectures and seminars Examination: Individual written exam Compulsory parts: Seminars are compulsory and any absence must be compensated for after discussion and agreement with the course-leader Number of students: 12 - 12 Selection of students: Priority will be given to students involved in intercultural research with children in a Public Health perspective and in order of time of application if amny applicants. More detailed information: The Convention on the Rights of the Child is the framework of the course and the focus is on how children and adolescents can participate in research. Methods for data collection with children/adolescenst and for analysis with them and with respect for them and their situation. - 12 Course responsible Birgitta Rubenson 171 Stockholm +(46) 8 52483389
[email protected] Department of Public Health Sciences Course contact Helena Faxelid 127 of 227
Karolinska Institutet 17177 Stockholm +(46) 8 52483389
[email protected] Department of Public Health Sciences
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Title: Thrombosis and hemostasis Course number: 2149 Credit points: 1.5 Date: 2009-03-09 - 2009-03-13 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Included in postgraduate course programme: Cardiovascular research Learning outcomes: The students should be able to: 1. Describe the molecular mechanisms, cell types, tissues and organs involved in hemostasis (primary hemostasis, blood coagulation and fibrinolysis). 2. Explain mechanisms of occurrence of thrombosis and bleeding disorders 3. Motivate the use of different models (in vitro-, epidemiological, animal model) to study hemostasis and thrombosis and apply them to a given project Contents of the course: Hemostasis and thrombosis will be discussed from the molecular, cellular, genetic, clinical and epidemiological viewpoints. Occurrence of bleeding disorders will also be touched upon . Examples of in vitro and animal models as well as clinical studies in hemostasis and thrombosis will be discussed. Type of teaching: Lectures, project group, presentation by students Examination: 1. Individual or group presentations at the end of the course. 2. Each student should prepare an OH about their own PhD project, and give a 5 min presentation. Compulsory parts: Examination is compulsory. Absent students will be given special task to turn in on later occasion Number of students: 10 - 25 Selection of students: Preference will be given to PhD students within the Cardiovascular programme. After that students will be accepted according to the date of registration as PhD student, older as PhD student coming first. More detailed information: The course will take place at the Centre of Molecular Medicine, Karolinska University Hospital in Solna, between 8:30 and 16:00. - 25 Course responsible Angela Silveira Karolinska Universitetssjukhuset, Solna, M1:01 17176 Stockholm +46851773224
[email protected] Atherosclerosis Res Unit Department of Medicine, Solna Course contact Angela Silveira 129 of 227
Karolinska Universitetssjukhuset, Solna, M1:01 17176 Stockholm +46851773224
[email protected] Atherosclerosis Res Unit Department of Medicine, Solna
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Title: Multifactorial immune mediated diseases - etiology and pathogenesis Course number: 2150 Credit points: 1.5 Date: 2009-03-09 - 2009-03-13 Språk: english Level: Forskarnivå Responsible department: Department of Medical Biochemistry and Biophysics Included in postgraduate course programme: Allergy,immunology and inflammation Learning outcomes: After completion of the course the students should be able to explain the term multifactorial immune mediated diseases (e.g. allergic, autoimmune, and inflammatory) and discuss basic clinical characteristics and disease mechanisms. They should be able to discuss the role of environment and genes in the etiology of such diseases, and in particular that the diseases are genetically complex. The students should also be able to describe some genetic strategies aimed at identifying risk genes. They should be able to explain how identification of risk genes can give insight into disease pathways, and discuss how such knowledge may enable disease prevention and therapy. Contents of the course: The course includes an overview on chronic immune mediated multifactorial diseases and the challenge they represent to medicine. It covers topics such as epidemiology, clinical characteristics, suggested or known disease mechanisms, complex genetics - in contrast to mendelian genetics, comparative genetics, forward genetics, proteomics, transcriptomics and translational medicine. Key concepts and techniques within each topic will be introduced, e.g. in genetics: linkage, association, SNP, microsatellite, and so on. Type of teaching: Each day, the course combines a set of morning overview lectures followed by an afternoon seminar with a task to solve, at either group or individual level. The tasks generally consists of "scientific projects" that are pursued by combining knowledge aquired during morning lectures with information that is either given and/or collected in databases (IT). Examination: Examination is based on interactive engagement in daily tasks, as well as completion of a course evaluation form Compulsory parts: All lectures, seminars and group- or individual- tasks are compulsory. Compensation for absence can be discussed with the course director. Number of students: 10 - 16 Selection of students: Selection will primarily be based on proximity of the student PhD project to the course topics, and secondly on the time since PhD-student registration. More detailed information: The course focuses on complex genetics while providing a broad context. Speakers last year included Profs. L. Klareskog (RA), T. Olsson (MS), L. Alfredsson (Epidemiology), H. Luthman (Complex genetics), P. Ericsson (atherosclerosis/myocardial infarction) and Dan Holmberg (T1D). Beside the topics mentioned, lectures were also given on e.g. asthma, epigenetics, genetic manipulations, transcriptomics, proteomics and disease treatment. - 16 131 of 227
Course responsible Johnny C. Lorentzen Division of Medical Inflammation Research, Scheeles väg 2, B2 Plan 4 171 Stockholm 076-2610988
[email protected] Department of Medical Biochemistry and Biophysics Course contact Johnny C. Lorentzen Division of Medical Inflammation Research, Scheeles väg 2, B2 Plan 4 171 Stockholm 076-2610988
[email protected] Department of Medical Biochemistry and Biophysics
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Title: Cardiovascular Epidemiology Course number: 2154 Credit points: 1.5 Date: 2009-03-30 - 2009-04-03 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Cardiovascular research Learning outcomes: Students having successfully completed the course are expected to recognize different risk factors or risk indicators for cardiovascular disease and different cardiovascular phenotypes. Students should be able to discuss the study designs most commonly used within cardiovascular epidemiology. In addition, students should be able to interpret study results critically. Contents of the course: Overview and discussion of risk factors/risk indicators - environmental, genetic and biochemical. Discussion of theories and concepts related to common epidemiological and genetic study designs - cohort, case-control, family-based studies and genetic association studies. Type of teaching: Lectures (cathedral) Group work, to consolidate and reflect upon concepts introduced during the course. Seminars. Examination: Learning outcomes will be assessed using 1) a short written examination covering different research methods used within cardiovascular epidemiology, and 2) participation in group work and article seminars. Compulsory parts: Participation in group work and article seminars is mandatory. Compensation through an individual written assignment. Number of students: 12 - 25 Selection of students: Priority will be given to registered Ph D students with projects within the field of the course and motivation given in the application. More detailed information: The course will be given at KI Solna campus. Course leaders are Karin Leander, Bruna Gigante and Ulf de Faire. From an epidemiological perspective, the course will give an overview of cardiovascular risk factors ¿ classical and more recent ones. Discussions during the course will involve the emerging role of biomarkers in cardiovascular research and the role of genetic- and environmental influences. Further, invited speakers will cover the design of clinical trials and their implications for primary and secondary prevention of cardiovascular disease. One lecture will also illustrate the potential use of different population-based registers within cardiovascular research. It is advisable for students to have some basic background knowledge of epidemiology, genetics, and of the biology of the cardiovascular system. However, this is not a formal requirement. A self-test on background knowledge as well as reading material covering basic epidemiology, genetics and cardiovascular biology will be distributed to students before the course starts. Participation in group examinations on day 2, 3 and 4 in the afternoons is compulsory, as well as participation 133 of 227
in individual written exam on day 5, early afternoon. Compensation through an individual written assignment. - 25 Course responsible Ulf de Faire IMM, Cardiovascular Epidemiology Box 210 171 Stockholm 08-52487480
[email protected] Institute of Environmental Medicine Course contact Karin Leander IMM, Cardiovascular Epidemiology Box 210 17177 Stockholm 08-52487498
[email protected] Institute of Environmental Medicine
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Title: Demography and Health Course number: 2155 Credit points: 1.5 Date: 2009-04-20 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: At the end of the course students should: -Have an overview of the basic measures in formal demography as well as the relationship between demographic theories to epidemiology and public health research. -Be aware of global trends in fertility, migration, mortality and morbidity at different spatial levels and for different social groups - Have an understanding and ability to explain the relationships between health (and ill-health), mortality and demographic change in a variety of global settings. -Understand how to collect mortality data in the presence or absence of a functional registration system as well as the importance of life tables in the study of mortality. -Have an overview of the relationship between migration and health. In addition within the Migration and health concept , understand the role of ethnicity as well as it¿s relation to health in different societies Contents of the course: The course will starts with an "Introduction to demograpy" and its relationship with epidemiology and public health. In this introductory part the basic measures of mortality, fertility and migration will be explained. The next part will address the interaction of demographic processes (fertility, mortality, migration) and population characteristics. Following that will be the notion of demographic transition (as cross-section of global fertility patterns, and historical model); epidemiologic transition and health transition. In this section an emphasis will be given to the study of mortality (its measures, cohort and period life tables and survival analysis). After, fertility and population policy will be addressed. Finally, the nature, causes, types and effects of migration; the relationship between migration and population health in developed and developing countries Type of teaching: The course is concentrated to one week. Teaching will be performed through lectures and exercises. Examination: The examination consists of a written individual examination. The examination will be assessed using the following grades: passed or not passed/failed. For the students who have not received a passing grade at the regularly scheduled examination a re-sit examination can be arranged. Compulsory parts: No compulsory moments. Number of students: 20 - 25 Selection of students: Applications will be ranked according to motivation for applying More detailed information: Place: The course will be given at the Division of Social Medicine, Norrbacka Building, Stockholm. Schedule Course 2155 - (20-124 April 2009) 135 of 227
Monday - Course Introduction; Basic concepts in ¿Formal Demography¿ Tuesday - Mortality and the Demographic transition in developed and developing countries Wednesday : Fertility and population health in developed and developing countries Thursday: Migration, ethnicity and health in developed and developing countries Friday ¿ Examination Teachers course 2155 Local: Gloria Macassa MD, MPH (Medical Demography), PhD Epidemiology Invited: Guest Teachers: Gebremarian Woldemichael, MSc Statistics, PhD Demography , Associate Professor, Department of Sociology, Stockholm University;Gebrenegus Guilagaber, Linceciate in Demography, PhD in Statistics, Associate Professor, Department of Statistics, Stockholm University - 25 Course responsible Gloria Macassa Norrbacka plan 2 171 Stockholm 46-08-7373611
[email protected] Department of Public Health Sciences Course contact Carlos Andres Fandino-Losada Norrbacka plan 2 171 Stockholm +46 (0)8 7373893
[email protected] Department of Public Health Sciences
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Title: Genetics and epigenetics in stem cell biology Course number: 2157 Credit points: 1.5 Date: 2009-04-20 - 2009-04-24 Språk: english Level: Forskarnivå Responsible department: Department of Cell and Molecular Biology Included in postgraduate course programme: Cell Biology and Genetics Learning outcomes: fter the completed course, the students should be able to describe the basic genetic and epigenetic mechanisms involved in stem cell renewal and differentiation, theoretize and relate the epigenetic and genetic mechanisms to stem cell renewal and differentiation (lineage selection, cell cycle regulation, cancer development). After the course, the students should demonstrate a critical scientific way of thinking concerning the course contents. Contents of the course: The course presents state-of-the art advances in the understanding of genetic and epigenetic processes underlying the regulatory principles in stem cell biology. Type of teaching: The pedagogic learning activities on the course consist of cathedral lectures, group discussions, data processing and student presentations. Examination: The students are examined for the desired knowledge and attitudes outcomes formatively and individually during the discussions with expert tutors, and summatively in the final seminar based on presentation of projects.. Compulsory parts: Participation in the group discussions and student presentations is mandatory. Absence from the obligatory moments is compensated according to the instructions of the course director. Number of students: 12 - 20 Selection of students: The selection is based on a comprehensive assessment based on the relevance of the PhD project for the course content and the personal motivation letter to attend the course. More detailed information: The course is a collaboration between the Stockholm branch of Ludwig Institute for Cancer Resarch, Cell biology and Genetics program, and Center of excellence in Developmental Biology and Regenerative Medicine (www.dbrm.se). The main examiner is Ola Hermansson. - 20 Course responsible Jonas Muhr LICR von Eulers v 3 171 Stockholm 08-524 871 57
[email protected] Department of Cell and Molecular Biology Course contact 137 of 227
Inger Westin Box 285 Karolinska Institutet 17177 Stockholm 08-52487371
[email protected] Department of Cell and Molecular Biology
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Title: From Science to Business -- Concepts in Biotechnology Course number: 2159 Credit points: 7.5 Date: 2009-03-30 - 2009-05-28 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Learning outcomes: The learning outcomes for the course can be subdivided into two broad areas; i) Biotech business including finance, strategy, law and regulations and ii) Entrepreneurship and innovation. After the course the candidates will be able to: Biotech business -express understanding for the field of biotechnology business -understand and demonstrate knowledge of the development and management of biotechnology businesses -argue for advantages and disadvantages with public and private financing of early stage companies -communicate basics in strategy and tools for science based companies (business plan, collaboration between large and small companies, corporate intelligence, role of boards, human resource management etc) -demonstrate theoretical knowledge within the overall legal and regulatory framework for science based businesses (EU and US corporate law, patenting law, regulatory authorities) -integrate knowledge of key skill-sets for early-stage entrepreneurship and handle complexity within areas such as market and IP analysis, target product profile, business plan and budgeting. Entrepreneurship and innovation -understand and demonstrate how discoveries and inventions are commercialized -analyse, clearly communicate and discuss the context of entrepreneurship with both a specialist and nonspecialist audience -analyse and clearly communicate and discuss the context of entrepreneurship to both a specialist and nonspecialist audience -apply their understanding and knowledge of the basics of innovation and entrepreneurship in a broader context and relate to their own field of study -use their new skills and continue to independently learn more about the area of innovation and entrepreneurship -demonstrate understanding in the theory of clusters of innovation -express knowledge for the universities role in the innovation system Contents of the course: The knowledge intensive field of biotechnology has apart from being subject to high expectations from a macroeconomic perspective also attracted a strong interest from the large pharmaceutical companies and venture capitalists. The course deals with the development and management of biotechnology businesses, with a focus on commercialising discoveries and inventions. The course consists of seminars based on practice and theory of the different stages of business development as well as a group-project presented in writing and orally. In the seminars the candidates meet practitioners and researchers with a Swedish and international background. 139 of 227
The practitioners present specific experiences from starting and running knowledge intensive young businesses or from the financial, legal, political or corporate strategy fields. The broad picture is given by researchers in sociology or business administration with an insight in academic discoveries, start-up companies, venture capital, business expansion and selling of companies. In the group-project and case studies candidates and students from different schools will work together on topic of their choice from one of the main areas of the course. The course is divided into four components: 1.innovation & entrepreneurship 2.law and regulations 3.finance 4.strategy Type of teaching: A combination of guest speakers with theoretical and real-life experiences of starting, running and developing science based companies. Interactive seminars with focus on discussions on the different topics combined with actual use of the provided knowledge. Examination: Class attendance and participation. Group-thesis, case assignment and oral presentations. Compulsory parts: There is compulsory attendance in the seminars, case work and presentations. Failure to attend obligatory parts of the course may be compensated for by completion of appropriate assignments, decided on in agreement with the course leadership and judged on a case-to-case basis. Number of students: 10 - 25 Selection of students: Priority will be based on motivation. More detailed information: The learning outcomes for the course can be subdivided into two broad areas; i) Biotech business including finance, strategy, law and regulations and ii) Entrepreneurship and innovation. In the seminars students meet practitioners and researchers with a Swedish and international background. The practitioners present specific experiences from starting and running knowledge intensive young businesses or from the financial, legal, political or corporate strategy fields. The broad picture is given by researchers in sociology or business administration with an insight in academic discoveries, start-up companies, venture capital, business expansion and selling of companies. The course is given on KI campus Solna and is part of the SSES course curriculum. - 25 Course responsible Carl Johan Sundberg Berzelius väg 13 Stockholm
[email protected] Department of Physiology and Pharmacology Course contact Hanna Jansson UBE, Nobels väg 15 a 08-524 838 61
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Exploring human movement with computerised movement analysis systems Course number: 2194 Credit points: 3.0 Date: 2009-02-05 - 2009-03-06 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Learning outcomes: At the end of the course, the students should be able to: * formulate clear research questions in the field of movement science and be able to set up adequate experiments for them. * in groups, conduct a scientific experiment in the movement laboratory. * analyse kinematic, kinetic and EMG data. * clearly present the results in oral and written form (including graphs). *-- evaluate their results by comparing them with the litterature. Contents of the course: * Working in the lab with computerised movement analysis systems: o Kalibrering, datainsamling och analys o Signal processing of movement trajectories from reflecting markers, of Electromyography (EMG) and force plate data. * Biomechanics * Motor control * Muscle physiology * Training in experimental skills * Training in presentation skills Type of teaching: This course has three parts. The first part is a theoretical part, in which the students learn the basics of movement science by means of lectures, group work litterature studies and individual work (3 days). The second part is laboratory work in which the students learn a) the principals of computerised movement analysis systems with calibration, marker placement, EMG, and forceplate measurements; b) learn to formulate a movement scientific research question (PM); and c) learn to accomplish an laboratory experiment - group work (5 days). The last part is the presentation part, in which the students present their laboratory results in both a written rapport and in zig-zaw group seminars (2 days). Examination: The teachers give their judgement on the oral presentations and the written laboratory report. Moreover, student peer assessment on the oral presentations. Compulsory parts: This course has three compulsory parts: 1. Oral presentation of the movement scientific research question (PM-presentation). 2. Active participation in the laboratory experiment. 3. Active participation in the zig-zaw group seminars. Absence at these compulsory parts, the students have to compensate this with: 1. A written presentation of the movement scientific research question (PM). 2. Participate in an other laboratory experiment. 3. A written summary of a number of laboratory reports, including reflecting comments. 141 of 227
Number of students: 12 - 30 Selection of students: The progress of the student, i.e. the planned time left to disertation. The lesser time left, the higher chans to participate in the course. More detailed information: The course is given at the movement laboratorium in Huddinge (ANA 23). Associate professor Helga Hirschfeld will be in charge of the course content. The course will be held over a five week period with 2 course days per week (Thursday / Friday). - 30 Course responsible Wim Grooten 23100 141 Huddinge 08-42488876
[email protected] Sjukgymnastik Department of Neurobiology, Care Sciences and Society Course contact Wim Grooten 23100 141 Huddinge 08-42488876
[email protected] Sjukgymnastik Department of Neurobiology, Care Sciences and Society
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Title: Social skills: Presentation techniques, cooperation and relationships Course number: 2198 Credit points: 3.0 Date: 2009-01-27 - 2009-05-26 Språk: english Level: Forskarnivå Responsible department: Departement of Woman and Child Health Learning outcomes: After attending this cours the PhD student will: - have tools for presenting their research in a successful manner - have gained an understanding of how an audience is influenced by for example our body language - have learned to make the best out of him/herself as a speaker - have a deeper understanding of mechanisms promoting and reducing cooperation between individuals and within a group - understand why cooperation might be difficult and in which way humans are unique in the way we cooperate - understand more about how to apply the mechanisms of cooperation in a group Contents of the course: Presentation technique: Lectures on themes like body language and status. Practical sessions on body language, presentation, improvisation, and different techniques to make your presentation more interesting and help you deliever your message. Everyone can improve their skills in expressing themselves in an inspiring, secure, and enthusiastic way, no matter if the purpose is to give a lecture in front of a big audience or to express your opinion within a group. With the help of some improvisation exercises you will learn how to use your personal strengths in order to increase your self esteem. Cooperation and relationships: Theory, economic games, discussions, and assignments will be mixed. You learn about the mechanisms and dynamics of cooperation; how you can influence cooperation in a group and how this can be translated to your every day work as a member of a research group. By understanding and applying the mechanisms which influence how prone we are to cooperate we will become more successful in our relationships with other people, both professionally and in private life. Type of teaching: Group assignments, lectures, economic games, discussions, supervision in group, oral presentations, individual assignments. Examination: Oral presentation and individual assignments. Compulsory parts: Written assignments as compensation for missed compulsory parts. Number of students: 10 - 15 Selection of students: a) Personal motivation on why the PhD student wishes to attend the course b) Date of half time control and when dissertation is planned 143 of 227
c) registration date More detailed information: Welcome to apply for the course on Social Skills! We would like to inform you that we focus a lot on the personal motivation in the application when deciding who will participate in the course. Therefore we would like to ask you to spend some extra time on writing something about why you are applying for this course, in which way it would be of value for yourself and your doctoral studies, what you expect of the course, why you think cooperation is important in research and also something about yourself and your PhD studies. This course is in English, including all lectures and assignments. Lecturers are Sofia Czinkoczky and Carl-Adam Wachtmeister. Sofia Czinkoczky is an actress with many years of experience in giving courses in improvisational theatre and presentation technique. Sofia has been head of Stockholms Improvisationsteater. Since 1999 she has been working in the field of education and giving courses in communication, improvisation, and creativity for companies. Her passion is to make people dare using their innate creativity, which also show in her courses on presentation technique. Carl-Adam Wachtmeister did his PhD on behavioural biology and has about 15 years of research and teaching experience in the field of human and animal behaviour. Today he is a senior consultant, with assignments in both universities and companies. In his work Carl-Adam is focusing on cooperation and cultural change. Schedule for the course will be handed out on the first day of the course. The lectures will be held on the second and fourth Tuesday every month (i.e. Tuesday w5, w7, w9, w11, w13, w16, w18, w20, w26). Some of these days are scheduled for groupwork (half/full class) and some are assigned for individual work. - 15 Course responsible Kristina Gemzell Danielsson Karolinska sjukhuset i Solna, WHO-center 08-517 79 539
[email protected] Departement of Woman and Child Health Course contact Anna Hildenbrand Karolinska sjukhuset i Solna, C4U1
[email protected] Departement of Woman and Child Health
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Titel: Social kompetens: Presentationsteknik, samarbete och relationsbyggande * Kursnummer: 2198 Antal högskolepoäng: 3.0 Datum: 2009-02-05 - 2009-06-04 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för kvinnors och barns hälsa Kursens lärandemål: Efter genomgången kurs ska doktoranden ha: - verktyg för att på ett framgångsrikt sätt presentera sina forskningsresultat - förståelse för hur vi påverkar en publik genom exempelvis vårt kroppsspråk - lärt sig ta till vara på sina styrkor som talare - kunskap om hur man disponerar och strukturerar ett budskap respektive en presentation - en djupare förståelse för de mekanismer som främjar respektive bryter ner samarbetet mellan individer eller inom en grupp - förståelse för varför samarbete är svårt, på vilket sätt människan är unik i djurvärlden i sitt sätt att samarbeta - en ökad förståelse för hur vi kan tillämpa samarbetsmekanismerna i en grupp Kursens innehåll: Presentationsteknik: Teoretiska övningar omfattar bland annat strukturering av ett budskap och en presentation, vilka media vi har att tillgå för att nå ut till en publik samt vikten av kroppspråket. De praktiska momenten omfattar egna presentationer. Alla kan träna upp sin förmåga att uttrycka sig engagerande, inspirerande och säkert, vare sig det handlar om att föreläsa inför en stor publik eller att framföra åsikter i en grupp. Genom improvisationsövningar lär du dig använda dina personliga styrkor medvetet för att bli mer självsäker, närvarande och uttrycksfull. Samarbete och relationsbyggande: Teori varvas med gruppövningar och vi går igenom samarbetets mekanismer och dynamik, hur vi kan påverka samarbetet i en grupp och hur detta ser ut i praktiken i er vardag som medlem i en forskargrupp. Genom att förstå och tillämpa de mekanismer som påverkar vår benägenhet att samarbeta kommer vi att bli mer framgångsrika i våra relationer till andra människor, vare sig det gäller en professionell relation eller privat. Arbetsformer: Gruppövningar, föreläsningar, IT-användning (powerpoint), handledning i grupp, muntliga presentationer, enskilt arbete. Examination: Avslutande presentation samt inlämningsuppgift. Obligatoriska moment: Eventuell frånvaro från obligatoriska moment kan kompenseras genom skriftlig inlämningsuppgift samt extra uppsamlingseminarium. Antal studenter: 10 - 15 145 of 227
Urval av studenter: a) Motiveringen till varför studenten vill genomgå kursen. b) Om halvtidskontroll har skett och när studeranden har för avsikt att disputera. Ytterligare information: Välkommen att söka kursen i Social kompetens! Vi vill informera om att stor vikt läggs vid den personliga motiveringen i ansökan när kursplatserna fördelas och därför be dig lägga ner lite extra tid på att skriva några rader, helst på svenska, om varför den här kursen vore av betydelse för dig och dina doktorandstudier, vad du förväntar dig få ut av den, varför du tycker att samarbete är viktigt för forskningen och dessutom något om dig själv och din forskning. Kurs 2198 ges på svenska och det är av avgörande betydelse att du behärskar språket i tal och skrift. Föreläsare på kursen är Sofia Czinkoczky och Carl-Adam Wachtmeister: Sofia Czinkoczky är skådespelare med stor erfarenhet av kurser i improvisationsteater och presentationsteknik. Sofia har tidigare arbetat som konstnärlig ledare på Stockholms Improvisationsteater. Sedan 1999 arbetar hon med utbildning och ger kurser i kommunikation, improvisation och kreativitet för företag. Sofia brinner för att få människor att våga använda mer av sin inneboende kreativitet, vilket tydligt märks i hennes kurser i presentationsteknik. Carl-Adam Wachtmeister är disputerad beteendebiolog med närmare 15 års erfarenhet av forskning och undervisning om beteende hos människor och djur. Idag arbetar han som konsult och verkar både inom universitetsvärlden och företagsvärlden, med regelbundna uppdrag bl.a. för Karolinska institutet och Stockholms universitet. Carl-Adam har specialiserat sig på samarbete och kulturell förändring. Schema för kursen delas ut i samband med kursstart. Undervisningen är förlagd till första och tredje torsdagen i månaden under kurstiden, dvs v.6, v.8, v.10, v.12, v.14, v.16. v.19, v.21 och v.23 varvid vissa dagar omfattar schemalagt arbete i hel/halvgrupp och andra är avsatta för individuellt arbete. Ansvarig för kurstillfälle Kristina Gemzell Danielsson Karolinska sjukhuset i Solna, WHO-center 08-517 79 539
[email protected] Institutionen för kvinnors och barns hälsa Kontaktperson för kurstillfälle Anna Hildenbrand Karolinska sjukhuset i Solna, C4U1
[email protected] Institutionen för kvinnors och barns hälsa
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Title: Clinical cell transplantation. Course number: 2201 Credit points: 1.5 Date: 2009-03-16 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department for Clinical Science, Intervention and Technology Learning outcomes: After the course, the student will be able to describe the basics of stem cell biology and the immunological mechanisms behind engraftment and rejection, and how tolerance develops after transplantation. The student will also be able to describe how central animal models used in transplantation research function. The student will be able to extract and integrate information from state-of-the-art lectures in combination with overview articles and literature searches on the internet within the research field. Contents of the course: The course covers key concepts in translational cell transplantation research from the laboratory to the patient in the clinic. This includes a general overview of stem cell biology, transplantation immunology and the most common animal models used in transplantation research. Furthermore, an advanced summary of the latest events in the transplantation field will be given by experts. Ethical dilemmas in the transplantation area will be presented and discussed. The student take an active part, contribute and value discussions on ethical predicaments in the transplantation area. Type of teaching: The pedagogic framing of this course is based on lectures with corresponding review papers. The course includes two workshops with illustrative predicaments where the students are required to take an active part in the discussions. Group project in pairs will be conducted where the students discuss and integrate information from the lectures and review papers, which should be supplemented with information from other sources, like the internet. The student prepare and present their work orally. The course includes a site visit to a GMPlaboratory. Examination: Group presentations of the course projects. The individual performance of each student is evaluated separately. Compulsory parts: Participation in the group project, including presentation. Absence from obligatory parts of the course is compensated according to instructions from the course director. Number of students: 10 - 20 Selection of students: The selection process will be based on a comprehensive assessment of the students: 1. Motivation for the course. 2. Topic of their PhD project. The student needs to state if they are a clinician or basic researcher. 3. Years since PhD registration More detailed information: The course is organised by the Karolinska Institutet Research Network Tissue and Motion and is given at Karolinska University Hospital Huddinge. - 20 Course responsible Rachael Sugars Karolinska Institutet Novum Hälsovägen 7-9, Hiss A plan 7 147 of 227
141 Huddinge 08 746 02 35
[email protected] Center for Oral Biology Institute of Odontology Course contact Rachael Sugars Karolinska Institutet Novum Hälsovägen 7-9, Hiss A plan 7 141 Huddinge 08 746 02 35
[email protected] Center for Oral Biology Institute of Odontology
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Title: Gender-based violence and child abuse Course number: 2203 Credit points: 4.5 Date: 2009-05-04 - 2009-05-22 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: Upon completion of this course, students should be able to: i) apply public health models to gender-based violence and child abuse ii) demonstrate knowledge of the extent, distribution, riskfactors and consequences of gender-based violence and child abuse iii) associate gender-based violence to child abuse iv) design appropriate preventive measures to manage gender-based violence and child abuse v) understand challenges to measurement of gender-based violence and child abuse vi) analyse data regarding gender-based violence and child abuse using statistical programming Contents of the course: The course will introduce students to theories on gender-based violence and child abuse. Students will learn in detail about extent, distribution, riskfactors and consequences of gender-based violence and child abuse, as well as strategies to prevent these phenomena. Gender-based violence and child abuse will be embeded in the ecological framework, empowerment and social theories to understand their significance in Public health. The intergenerational recycling of violence (i.e. the connection between child abuse and gender-based violence in adulthood) will be scrutinised. In addition the measurement of gender-based violence and child abuse and related challenges as well as challenges to screening of these phenomena will form an important part of this course. Issues of data collection, synthesis, analysis and reporting of gender-based violence and child abuse will be addressed. Type of teaching: Lectures, seminars, group discussion and data analysis in SPSS. Examination: In small groups students will be examined on their ability to integrate the above learning outcomes (i-iii) in a research plan concerning gender-based violence and/or child abuse and their ability to discuss preventive measures, analytic methods and challenges to measurment of gender-based violence and/or child abuse in accordance with learning outcomes (iv-vi). This will be examined in writing and orally in form of group presentations. Compulsory parts: All lectures and group discussions are compulsory. Inability to attend these course moments will imply additional exercises for the participant. Number of students: 15 - 25 Selection of students: All applicants are required to write a short motivation letter (about half a page) indicating why she/he feels she/he should be selected for this course. The motivation letter will guide in the selection process if more students apply for the course than there is accomodation for. More detailed information: The course will be given on location (i.e. KI). Renown researchers in the field, currently in Sweden and from abroad will be invited to teach. Data from both developed and developing societies will be scrutinised and analysed - 25 149 of 227
Course responsible Stephen Lawoko Norrbacka plan 2 171 Stockholm 08-7373609
[email protected] Department of Public Health Sciences Course contact Ime John Norrbacka plan 2 171 Stockholm 08-7373609
[email protected] Department of Public Health Sciences
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Titel: Datorstöd i kvalitativ analys - NVivo Kursnummer: 2204 Antal högskolepoäng: 3.0 Datum: 2009-03-02 - 2009-05-04 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för neurobiologi, vårdvetenskap och samhälle Ingår i forskarutbildningspprogram Vård och Omsorg Kursens lärandemål: Efter genomgången kurs ska kursdeltagarna behärska datorprogrammet NVivo (senaste versionen) så väl att de kan använda dess vitala funktioner i analys av eget forskningsmaterial. Vidare ska de ha fördjupat sin kunskap om programmets styrka och begränsningar i relation till olika kvalitativa metodologier och deras bakomliggande vetenskapsteoretiska ansatser. Kursens innehåll: Inledande föreläsning/seminarium kring underliggande logik och vetenskapsteoretiska grunder för olika kvalitativa ansatser, med fokus på slutledningslogiker, teorins plats i analysen - deskriptiva, teoritestande och teorigenererande ansatser, triangulering och multistrategiska förhållningssätt. Fyra arbetspass med genomgång och arbete med eget material under handledning varefter deltagarna ges möjlighet att arbeta med eget material. Avslutande uppföljningsdag baserad på deltagarnas frågor och problemställningar kring programmet/användningsområden. Arbetsformer: Kursen omfattar totalt två veckors heltidsstudier, dels i seminarieform, dels i datasal (undervisning och handledda övningar med diskussion). Dessutom förutsätts studenterna arbeta aktivt med att tillämpa NVivo på eget material under hela kursperioden. Viss individuell handledning kommer även att kunna förmedlas via t ex e-post mellan kurstillfällena. Examination: Kursen examineras genom en individuell uppgift där deltagarna författar ett pm (4-5 sidor) där de redogör för hur de vill använda programmet på eget material och på vilka metodologiska och vetenskapsteoretiska grunder detta i så fall skall ske. Obligatoriska moment: Samtliga träffar är obligatoriska. All course meetings are compulsory. Vid frånvaro från de schemalagda kurstillfällena får deltagaren göra kompletterande övningsuppgift/er. Antal studenter: 10 - 12 Urval av studenter: Förtur ges till doktorander antagna i Nationella forskarskolan i vård och omsorg. Antagning av övriga sökande baserad på den skrivna motiveringen. Ytterligare information: 151 of 227
Kursen ges vid Örebro universitet/Nationella forskarskolan i vård och omsorg. Undervisningen kommer att ges under sex hela dagar, med fem dagar under en inledande två-veckorsperiod i form av inledande föreläsning/seminarium samt fyra arbetspass med genomgång och arbete med eget material under handledning den 2-10 mars. Avslutande uppföljningsdag den 4 maj. Ansvarig för kurstillfälle Lena von Koch Fack 23 200 141 Huddinge 070 513 30 55
[email protected] Sektionen för arbetsterapi Institutionen för neurobiologi, vårdvetenskap och samhälle
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Title: Social and Economic Determinants of Health in Developing Countries Course number: 2205 Credit points: 7.5 Date: 2009-05-04 - 2009-06-08 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: At the end of the course students should be able to: - Explain the social, cultural and economic factors that influence health in low and middle income countries -Identify variations in social, cultural and economic factors and how these are reflected in health disparities among population groups in low and middle income countries -To explore the pathways by which social, cultural and economic conditions affect individual risk factors and economic policies and their influences on populations of low and middle income countries - Articulate a social determinants perspective on health in low and middle income countries. Contents of the course: The course will start by introducing concepts of what are social determinants of health and why is important to study them in the context of developing countries. In addition during the introductory part, the course will explain how social stratification influences health outcomes in places where many people still live below poverty line. Following that the course will explain how factors such as poverty, culture, ethnicity, place of residence, war, globalization, and other array of factors influence health in low and middle income countries. The role of health care as a determinant of population health in low and middle income countries will be addressed. The course will address the social and economic determinants of health with a perspective which will target the major causes of disease in childhood, adulthood and elderly populations in low and middle income countries. Furthermore, the course will give an overview of research methods in social epidemiology with applications for developing countries. Type of teaching: The course will be held during five weeks. Teaching will be performed through lectures, exercises, group work and assignments Examination: The examination consists of a written individual examination. The examination will be assessed using the following grades: passed or not passed/failed. For the students who have not received a passing grade at the regularly scheduled examination a re-sit examination can be arranged. Compulsory parts: No compulsory moments Number of students: 20 - 25 Selection of students: Applications will be ranked according to motivation for applying More detailed information: Place: the course will be given at the Division of Social Medicine, Norrbacka Building Course Schedule: Social and Economic Determinants of Health in Developing Countries 153 of 227
Week I (4-8 May 2009) - Introduction to the course - Social determinants of health: what are they?: The health of populations versus the health of individuals - Inequalities in health: what are they and why study them in developing countries - Socioeconomic position and health outcomes in developing countries (social stratification in developing countries; the traditional western measures of socioeconomic position; measurement issues and recent empirical evidence) Week II (11-15 May 2009) -Ethnicity, culture, discrimination, gender, sex and power and inequalities in health in developing countries -Social capital, social support, networks, spirituality and population health in developing countries Week III (18-22 May 2009) -The concept of general susceptibility versus specific risk -Globalization and inequalities in health in developing countries -Research methods in Social epidemiology for developing countries I -Group work/assignments Week IV (25-29 May 2009) - Place, Neighbourhoods and health in developing countries - Social determinants of inequalities in health care in developing countries - Research methods in Social epidemiology for developing countries II - Group work/assignments Week V (1-5/8 June 2009) -Research methods in Social epidemiology for developing countries III -Group work/assignments presentation -Final examination Teachers - Local (KI) : Gloria Macassa MD, MPH, PhD Epidemiology (social epidemiology) ; Andres Fandino Losada MD, MSc (epidemiology); Kustuv Dhalal BsC Economics, PhD Social Medicine (health economics) - Invited: Gebrenegus Guilagaber, Licenciate in Demography, PhD in Statistics, Associate Professor (statistics), Department of Statistics, Stockholm University; Hamid Reza Khankeh, RN,MS,PhD, Assistant Professor, Department of Nursing, University of Social Welfare and Rehabilitation- Tehran,Iran - 25 Course responsible Gloria Macassa 171 76 Norrbacka 2fl, Stockholm Stockholm +46 (0)8 7373611
[email protected] Department of Public Health Sciences Course contact Gloria Macassa 171 76 Norrbacka 2fl, Stockholm Stockholm +46 (0)8 7373611
[email protected] Department of Public Health Sciences
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Title: Acute infections caused by Gram-positive infections Course number: 2206 Credit points: 1.5 Date: 2009-06-09 - 2009-06-15 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Huddinge Included in postgraduate course programme: Infection Biology Learning outcomes: The students should be able to 1. Describe fundamental concepts of the pathogenesis of acute infections caused by Gram-positive infections 2. Recognize and reflect on the function of defined virulence factors in relation to specific clinical manifestations of disease. 3. Identify common pathogenic mechanisms shared among Gram-positive bacteria and hypothesize on their importance for the disease progression 4. Reflect on novel preventive and therapeutic strategies in infections caused by Gram-positive infections. Contents of the course: The course covers clinical aspects as well as pathogenic mechanisms of acute infections caused by grampositive bacteria. It is composed of three parts: general lectures combined with cases and patient demonstrations, attendance at the Nobel symposium entitled "Acute Infections Caused by Gram-Positive Bacteria", and a round table discussion (part of the examination). Topics include emergence of multidrug resistance, immune evasion strategies, pathogenic mechanisms, and vaccine candidates. Type of teaching: The course includes general lectures that aim to prepare the student for the more advanced lectures given during the Nobel symposium. To enhance the learning, time for reflection and critical assessment of information has been scheduled in the form of buzz group and group discussions. Clinical aspects will be covered by interactive lectures, cases and patient demonstration at the intensive care unit. During the Nobel symposium, the student will be asked to cover a specific topic (chosen prior to the meeting), which should be summarized, presented and discussed during a round-table discussion on the last day of the course. Examination: Oral presentation in a round table discussions and a written report on a topic covered during the symposium. Compulsory parts: All parts include reflective practices and group works, and therefore participants are requested to attend scheduled sessions. Compensation for absence should be discussed with the course organizer, and may include literature review combined with a written report. Number of students: 10 - 20 Selection of students: Selection of students will be based on their written justification. Priority will be given to PhD students within the field of infection biology More detailed information: The course is composed of three parts: general lectures combined with cases and patient demonstrations (910/6), attendance at the Nobel symposium entitled "Acute Infections Caused by Gram-Positive Bacteria" (11155 of 227
13/6), and examination in the form of a round table discussion (1/2 day, 15/6). - 20 Course responsible Linda Johansson CIM F59 Karolinska hospital Huddinge 141 Stockholm 08-58582276
[email protected] Department of Medicine, Huddinge Course contact Linda Johansson CIM F59 Karolinska hospital Huddinge 141 Stockholm 08-58582276
[email protected] Department of Medicine, Huddinge
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Title: Molecular electron tomography for molecular medicine Course number: 2207 Credit points: 3.0 Date: 2009-01-19 - 2009-01-30 Språk: english Level: Forskarnivå Responsible department: Department of Cell and Molecular Biology Included in postgraduate course programme: Cell Biology and Genetics Learning outcomes: After the completed course, the students will be competent to carry out their own molecular electron tomography reconstruction with only minor guidance and understand the limitations of the method and how to optimize its us Contents of the course: Simplified theory for 3D reconstruction according to tomographic principles. Simplified theory for the refinement of 3D tomograms for noise reduction. Specimen handling for cryo-electron microscopy. Data collection in a modern automatized transmission electron microscope. Electron tomographic data processing. Stereo visualization of 3D reconstructed molecules. Type of teaching: The pedagogic learning activities on the course consist of cathedral lectures, group discussions, data processing and student presentations. Examination: The students are examinated individually during the data processing events. The final course examination is a project presentation in groups. Compulsory parts: Participation in the group discussions, data processing and student presentations is mandatory. Compensation through an individual written assignment. Number of students: 8 - 10 Selection of students: The selection is based on a comprehensive assessment based on the relevance of the PhD project for the course content and the personal motivation letter to attend the course. More detailed information: The course will show through theoretical and practical work how the 3D structure of a protein can be determined to about 2nm resolution directly in the buffer solution or in tissue. The students will get a direct hands-on experience of the processes involved in the practical and theoretical aspects of molecular electron tomography (MET). The students will be competent to carry out their own MET reconstruction and understand the limitations of the method and how to optimize its use. - 10 Course responsible Ulf Skoglund Box 285, KI 17177 Stockholm 157 of 227
08-52487364
[email protected] Department of Cell and Molecular Biology Course contact Inger Westin Box 285 Karolinska Institutet 17177 Stockholm 08-52487371
[email protected] Department of Cell and Molecular Biology
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Title: Computer modeling of toxicokinetics and cellular signaling pathways Course number: 2208 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Environmental factors and health Learning outcomes: After the course, the students should understand and be able to apply basic principles in toxicokinetic (TK), including physiologically based pharmacokinetic (PBPK) and toxicodynamic (TD) modeling. Further, they should be aware of modeling techniques for quantitative investigation of how biological systems respond to perturbations at the cellular level and of the biological circuits that control these responses. Contents of the course: The course will cover the following major topics: - Basic TK, PBPK and TD concepts. - Issues in model development and validation including sensitivity analysis, uncertainty and variability, Monte Carlo simulation. - Approaches to modeling biological response pathways including homeostasis, adaptation, threshold response, binary cell fate decisions, and irreversible differentiation. - Applications of TK, PBPK, TD and biological systems modeling in toxicological risk assessment. Type of teaching: This one-week full time course consists of daily lectures and daily mandatory computer exercises. The solutions to the latter are presented by the students the following day. Examination: Written examination and computer exercises. Compulsory parts: The computer tasks should be solved and presented under supervison of the course teachers. In case of absence, similar tasks will be given after the course, and solved as agreed with the course director. Number of students: 10 - 20 Selection of students: Applicants will be selected according to the motive for applying and the relevance to their PhD project. More detailed information: Main lecturers: Dr Melvin E. Andersen, Foreign Adjunct Professor at the Institute of Environmental Medicine (IMM), Karolinska Institutet, and Director of the Division of Computational Biology, The Hamner Institutes for Health Sciences Dr Gunnar Johanson, Professor, IMM. The course will be given in English at IMM, Campus Solna. The participants should bring a laptop computer. - 20 Course responsible 159 of 227
Gunnar Johnansson Box 210 171 Stockholm 08-5248 7752
[email protected] Institute of Environmental Medicine
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Title: Clinical and pre-clinical Virology Course number: 2209 Credit points: 1.5 Date: 2009-05-11 - 2009-05-18 Språk: english Level: Forskarnivå Responsible department: Department of Microbiology, Tumor and Cell Biologi Included in postgraduate course programme: Infection Biology Learning outcomes: *The student should know the transmission route and replication process of emerging viruses. *They should know how the viruses cause disease in man and also understand basic molecular mechanisms of pathogenesis and how the viruses interact with the host immune system. * They should know the available diagnostic methods for tdetection of Emerging viruses, They should also know the problems related to the diagnostics for the emerging viruses. *The course will also give a basic understanding about the effect of climate changes in spread of the emerging viruses. Contents of the course: Emerging virus infections is of growing global concern due to resurgence of the diseases in endemic countries. As illustrated by the outbreaks of novel viral diseases in recent years, it is clear that novel viruses can emerge in any part of the world at anytime. There is no doubt that viral infections has an big impact on human health and thereby the society in general. This course will focus on basic, both clinical and molecular virology. We will focus on emerging viruses and mechansims behind transmission, replication and interactions between the virus and the host immune system. Type of teaching: One week course. Theoretical lectures, seminars and visiting BSL3 and BSL4 laboratory. Examination: Students will pass provided they succeed to. - Seminar session: Grade will be given for the seminar given by the student - Writing Examination: Compulsory parts: - All lectures are obligatory. Parts they miss can be compensate by oral examination with a member of the course coordinating group on the missed session. Number of students: 15 - 30 Selection of students: Ph.D students with basic knowledge in Microbiology More detailed information: Time table: Everyday, from 0930 to 15.00. The course will be at Smittskyddsinstitutet. It will be several invited speakers from Umeå, Göteborg, Malmö, Kalmar, Linköping, Finland and Germany. - 30 161 of 227
Course responsible Ali Mirazimi Nobel väg 18 171 084572573
[email protected] Department of Microbiology, Tumor and Cell Biologi Course contact Ali Mirazimi Nobel väg 18 171 084572573
[email protected] Department of Microbiology, Tumor and Cell Biologi
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Title: Inequality in Health and Health Care -Theory, Methods and Measurements Course number: 2210 Credit points: 3.0 Date: 2009-04-14 - 2009-04-27 Språk: english Level: Forskarnivå Responsible department: Department of Learning, Informatics, Management and Ethics Included in postgraduate course programme: World Health Learning outcomes: At the end of the course students should: 1. be able to understand the social justice theories concerning equity in health and health care policy and systems. 2. be able to understand the most frequently used methods for analyzing inequality/inequity. 3. be able to understand the advantage and disadvantages of employing different methods. 4. be able to understand the differences and similarities of data collection procedures for inequality studies in developed and developing countries. 5. be able to analyze data from both developed and developing countries using computer programmes (Excel and STATA). 6. be able to interpret results from analyses in the light of social justice theories. 7. be able to understand how to use the information for health and health care policy and system reforms. Contents of the course: The course will have three different parts. First, the theories of social justice concerning equity in health and health care. Second, the most frequently used methods, measurements and rationale for analyzing inequality in health and health care. A number of modern measurements with a focus on the most frequently used ones, namely, Gini-coefficient and Concentration Index, Kakwani Index will be critically studied and taught. The students will even go through the procedures for preparing datasets in different contexts (individual and household data, in developed and developing country etc.). We shall even put emphasis on horizontal and vertical equity. Third, in the practical sessions, the students will go through the introduction of computer programme STATA. They will then analyze data for measuring inequality by focusing on research questions, methods, relevant measurements and finally, will interpret the results in the light of social justice theories, health policy and systems. Type of teaching: Teaching will be performed through lectures, practical sessions and assignments. Examination: The examination consists of practical case studies in computer laboratory and a written assignment. The examination will be assessed using the following grades: fail or pass. For the students who have not received a passing grade at the regularly scheduled examination, a reexamination can be arranged. Compulsory parts: No compulsory moment Number of students: 20 - 25 Selection of students: On the basis of relevance with applicant's current research area and the motivation. More detailed information: 163 of 227
Knowledge of basic quantitative methods is highly appreciated. Schedule and course material will be sent to the students latest 3 weeks before the course starts. Course will be held in Solna Campus at Karolinska Institutet. 25 Course responsible Jahangir Khan 17177 Stockholm +46 (0)8 737 38 24
[email protected] Department of Learning, Informatics, Management and Ethics Course contact Jahangir Khan 17177 Stockholm +46 (0)8 737 38 24
[email protected] Department of Learning, Informatics, Management and Ethics
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Title: Grundläggande Laboratoriesäkerhet Course number: 2211 Credit points: 1.5 Date: 2009-03-10 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Microbiology, Tumor and Cell Biologi Included in postgraduate course programme: Infection Biology Learning outcomes: After successfully completing this course you as a student are expected to have an overview of * the basic principles of laboratory safety, * overview of hazards that microorganisms pose, * overview of hazards that chemicals and isotopes pose, * the risks involved in working in a laboratory, * the rules and regulations in the field of laboratory safety including the responsibilities of the laboratory worker as well as of the management, * how to protect the individual and the environment, * the creation of risk assessments for laboratory work, * how to use the chemical registration system KLARA, * how to handle human biological material including blood and blood products, * introduction to the regulations governing work with cell cultures and micro-organisms (including gene modified), * introduction to the regulations associated with isotope safety, * how to handle waste, and * how to transport and ship laboratory material in a safe way. Contents of the course: The course aims at giving theoretical and practical aspects of laboratory safety. Focus will be on individual risk assessments and responsibilities. Type of teaching: The information will be given as seminars in English during a total of five days. The days will be dispersed during two weeks. During this time the students should also paricipate in two individual written risk assessments. Examination: The examination is based on an individual web-based examination with 20 multiple-choice questions and the project results. Compulsory parts: Both projects, the examination and presence during all the seminairs are compulsory. Students can compensate for absence through later individual assignments. Number of students: 10 - 40 Selection of students: Selection of students: 1) The students working in the laboratory are prioritized. 2) Registration date as a postgraduate student. More detailed information: The course is organized by the Biosafety Committee and the coordinator for work environment at Karolinska Institutet. Smittskyddsinstitutet will function as advisors by providing expertise in developing the course 165 of 227
curiculum. - 40 Course responsible Roland Möllby Nobels v 16 171 Stockholm 5248 7175
[email protected] Department of Microbiology, Tumor and Cell Biologi Course contact Jenny Sjöberg Nobels v 16 17177 Stockholm 5248 7230
[email protected] Department of Microbiology, Tumor and Cell Biologi
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Title: Human embryonic stem cells Course number: 2212 Credit points: 1.5 Date: 2009-05-11 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Biosciences and Nutrition Included in postgraduate course programme: Developmental Biology and Cellular Signaling Learning outcomes: The objectives of this course are that at the conclusion of this course students should have a good understanding of: ¿Folliculogenesis and Fertilization ¿Pre implantation Embryology ¿Criteria of selected or scoring the blastocysts for isolation of ICM ¿Derivation methods of hESCs ¿Culture condition of hESCs ¿Main components of the culture system (culture media, tissue culture plastics, gases, incubators, workstations, laboratory environment, input materials) ¿Physical-chemical properties of culture system (osmolarity and pH of culture media, temperature, light levels) and how they can be influenced ¿Nutritional requirements of the blastocyst and hESCs ¿Functional characteristics of different tissue culture incubators ¿The influence of the laboratory and clinic environment on hESCs ¿Developmental milestones ¿Students should know the prospective possibilities of having a good culture system ¿Students should be aware of the general aspects and implication of the stem cells research and the potentiality that these represent for clinical application ¿Characterization of the embryonic stem cells and the importance of the pluripotency of these cells ¿The different differentiations assay on stem cells and what is ongoing in this field ¿The immunorejection problem and the production of isogonics embryonic stem cells by somatic cell nuclear transfer or therapeutic clone (SCNT) ¿The pluripotence induction of somatic cell by transduction, (the iPS cells) ¿Finally the students will improve their capacity to produce coherent, logical and concise explanations of data and concepts - both written and oral, through consideration of the course material. ¿Students will also develop their ability to criticize scientific literature related with hESC technology and reproduction physiology in a constructive and informed fashion ¿Be aware of potential development of hESC technology in the future. Contents of the course: Divide in lectures and laboratory work 1. Embryology ¿theory¿ (lectures) 2.Culture system (lectures) 3.Human Embryonic Stem cells culture (lectures) 4. Characterization (lectures) 5. Laboratory demonstrations 6. Genetics (lectures) 167 of 227
7. Induction of different cell types (lectures) 8. Reprogramming (lectures) 9. Stem cells therapy and challenge (lecture) 10. Future in human embryonic stem cells (lecture) Course test, evaluation, discussions, examination and closing of course: Type of teaching: The course (human embryonic stem cells) runs for one week every year, with lectures and laboratory practical demonstrations. Examination: Writing individual- examen Compulsory parts: The laboratory parts are obligatory. If absent at laboratory activity; student should present a literature work related with the subject of the missing activity Number of students: 12 - 17 Selection of students: Students will be selected after their need to go this course and motivation More detailed information: Human embryonic stem cells course will be held at Karolinska University Hospital, Huddinge - 17 Course responsible José Inzunza Novum, Hälsovägen 7-9,Huddinge 14157 Stockholm +46858583739
[email protected] Department of Biosciences and Nutrition Course contact José Inzunza Novum, Hälsovägen 7-9,Huddinge 14157 Stockholm +46858583739
[email protected] Department of Biosciences and Nutrition
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Title: Demography, health and society in an ageing population Course number: 2213 Credit points: 3.0 Date: 2009-03-09 - 2009-04-06 Språk: english Level: Forskarnivå Responsible department: Department of Neurobiology, Care Sciences and Society Learning outcomes: After accomplishing this course, participants are expected to be able to: - Describe and explain the basic demographic terms and methods used within the frame of the course. - Provide an overview of the main issues of population developments, during the 20th century until today, in Sweden in an international perspective - Describe, explain and distinguish between different ways of measuring health in the elderly population and understand the different hypotheses for health trends that are presented. - Identify and discuss future societal challenges that might arise from an ageing population, based on the aspects dealt with during the course. -Relate Swedish population development to other aspects of the development of modern society. Contents of the course: The course offers an introduction to the discipline of demography and its theory, methods and sources of data as it relates to the aging population. Part one of the course will focus on stipulations for, and consequences of, different population processes (fertility, mortality and migration). Attention will be given to ¿the population problem¿ -- low birth rates and an ageing population. Population growth in Sweden will be discussed in an international perspective. The main part of the course will focus on health, health inequalities and health development among older adults, including the interplay of mortality and morbidity in the elderly population and changes over time in this relationship. Another focus will be on various social and economic challenges for the welfare state and for the family as the population ages. These include challenges for the health and old age care system, challenges for the pension system and the consequences for the family and younger generations that an ageing population entails. The aim of the course is to increase understanding of the demographic factors that underlie many current societal issues, globally and in Sweden. Type of teaching: Teaching is conducted through lectures and group discussions of materials from assigned readings. Examination: Assessments methods used are group assignments along with written and oral individual tasks. The oral part includes participation in general discussions as well as presentation of the group's work on the specific topic. The presentations are graded ¿pass¿ or ¿not pass¿. A ¿not pass¿ must be upgraded by means of a written paper, amounting to independent work on specific questions related to the contents of the course until the grade ¿pass¿ is given. The home exam paper constitutes individual work related to the course one or several questions that are relevant to the course. Students must also read and critically discuss another course participant's paper at the final seminar. Students who do not obtain a passing grade in the written or oral examination will be offered a second chance to resubmit the written or oral examination (in written form) within two months of the final day of the course. Compulsory parts: 169 of 227
The group discussion as well as the oral and written examination tasks are compulsory. Absence from the group discussion and the oral part must be compensated with a written assignment. Number of students: 10 - 20 Selection of students: Relevant research plan and motivation for participation More detailed information: Literature will be complemented by lecturers - 20 Course responsible Carin Lennartsson Gävlegatan 16, 11330 Stockholm 08-6905853
[email protected] Aging Research Center (ARC), NVS Department of Neurobiology, Care Sciences and Society Course contact Carin Lennartsson Gävlegatan 16, 11330 Stockholm 08-6905853
[email protected] Aging Research Center (ARC), NVS Department of Neurobiology, Care Sciences and Society
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Title: Redox regulation, oxidative stress and selenoproteins Course number: 2214 Credit points: 3.0 Date: 2009-05-18 - 2009-05-22 Språk: english Level: Forskarnivå Responsible department: Department of Medical Biochemistry and Biophysics Learning outcomes: After the course, each student should have acquired the following knowledge: - Good knowledge of structure-function relationships for the major low molecular-weight antioxidant compounds found in cells (GSH, Ascorbate, tocopherol) - Good knowledge of the major antioxidant and redox regulatory systems and redox sensitive signaling pathways (glutathione-dependent systems, thioredoxin systems, Nrf2/Keap1, Yap1, peroxiredoxins, methionine sulfoxide reductases, peroxidases, catalases, superoxide dismutase, NADPHoxidase, oxidative burst, PTP regulation, cyt c, ASK-1) - Good knowledge of selenoprotein synthesis and selenoprotein function After the course, each student should also have the skill to present and discuss a redox-regulated research project at a level generally expected for presentations held at international cutting-edge conferences in the subject. Contents of the course: The course is planned as a joint training encompassing an international exchange graduate course, with students and lecturer's primarily recruited from Karolinska Institutet and the Redox Biology Center of the University of Nebraska in Lincoln (UNL), Nebraska, which is an NIH COBRE (Center of Biological Research Excellence) initative focused on research in redox biology. The course is planned to be annually held and will have the following major components: - Students from both UNL and Karolinska Institutet - Lecturers from both Karolinska Instituet and UNL - Held each spring, every second year at Karolinska Institutet and every second year at UNL Planned lectures will contain subjects such as the following examples: - "Glutathione S-transferases in redox regulation and glutathione dependent catalysis" - "Nitric oxide (NO) signaling in relation to redox state" - "Calcium signaling in oxidative stress and in relation to apoptosis" - "Glutaredoxin and thioredoxin systems" - "The concepts and effects of redox cycling and selenoprotein reactivity" - "Selenoproteomes and dedicated Cys- and/or Sec-dependent redox systems" - "Using protein crystallography to probe the function of redox active enzymes" - "Redox activities of proline in a cellular context" - "The effects of metals on metabolism and oxidative stress in human disease" - "With the sight on redox: glutaredoxin and thioredoxin systems in the ocular lens and their relation to cataract" - "Redox control of ion channels" - "How oxygen can be sensed in the carotid body" - "Mitochondrial production of reactive oxygen species in relation to human disease" s Type of teaching: 171 of 227
The course it is built upon a pedagogic framework of discussions between graduate students in redox biology with leading experts in the field, combined with cutting-edge lectures, training in oral presentation, career counceling sessions and a written exam for control of detailed basic knowledge in redox biology. It is the firm belief of the course organizers that this pedagogic framework should well support the students to obtain the learning objectives of the course. It should furthermore help the students to prepare for their next level of a career beyond the doctoral examination. The type of teaching will be: - Morning sessions with lectures in basic concepts as well as cutting-edge front-line research findings in the field - Afternoon sessions with student presentations followed by discussions between lecturers and students - Career discussions and future perspectives in the field of redox biology Examination: The student skills are examined as follows: - Evaluation of the degree of participation in student-lecturer discussions and the level of initiated comments and questions during those discussions (grade pass/not pass) - Evaluation of the presentation of the student's own project (grade pass/not pass) - Results at written examination (at least 60% right answers for the grade of pass) Attendence during compulsory parts of the course as well as the grade of "Pass" in all three parts of the examination must be fulfilled for a final grade of "Pass". Compulsory parts: Absence from any part of the course (lectures, student presentations, career discussions, exam and award ceremony) is generally not accepted but could in special cases be compensated by an individually tailored additional discussion and a special written examination organized by the course committee. Number of students: 5 - 10 Selection of students: No particular prior knowledge is required, but the students of the course are expected to be graduate students (registered PhD candidates) active within the field of redox biology and such students have priority over students not being active in a field of redox biology. Students are admitted according to the following priority groups: 1st priority: Registered PhD students in the field of redox biology, before half-time control 2nd priority: Registered PhD students in the field of redox biology, beyond half-time control 3rd priority: Registered PhD students in other research fields than redox biology, before half-time control 4th priority: Registered PhD students in other research fields than redox biology, beyond half-time control Within each priority group, admittance will be done according to the date of application to the course (earlier applications have priority). Assessment if a student is active in the field of redox biology will be performed by the course organizers based upon a short project description of the student, which should be given together with the application to the course. More detailed information: (Contact person at RBC/UNL: Vadim N. Gladyshev, Redox Biology Center, Department of Biochemistry, UNL, Nebraska, USA, tel: +1-4024724948, e-mail:
[email protected]) - 10 Course responsible Elias Arnér 46852486983
[email protected] Division of Biochemistry 172 of 227
Department of Medical Biochemistry and Biophysics Course contact Elias Arnér 46852486983
[email protected] Division of Biochemistry Department of Medical Biochemistry and Biophysics
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Title: Practical programming for scientist Course number: 2215 Credit points: 4.5 Date: 2009-02-02 - 2009-02-20 Språk: english Level: Forskarnivå Responsible department: Department of Medical Biochemistry and Biophysics Learning outcomes: After completing the course, the student will have acquired basic skills in computer programming. In particular, the student will understand the most important concepts in modern object-oriented programming, including how to install and use a modern integrated development environment (IDE), how to write a complete functional software application, and some useful techniques relevant to scientific practice. Contents of the course: The focus of the course is very firmly on practical programming. The course will cover the following topics: Introduction to modern object-oriented programming and commonly used programming languages. Obtaining, installing and using Visual Studio Express to write, run and debug a complete Windows application. Creating a simple graphical user interface (GUI). Overview of Internet resources for scientific programming and bioinformatics. Programming techniques relevant to scientific practice: reading, writing and parsing text files; performing mathematical calculations; analyzing DNA sequences; image analysis. Type of teaching: The course has two parts. Part one (two weeks) consists of half-day lectures followed by practical work under teacher supervision. Part two consists of an individual programming project, resulting in a complete, runnable application. The result of the individual project is presented and discussed on the last day. Examination: Oral examination in conjunction with the presentation of individual projects Compulsory parts: All lectures are compulsory, as well as the individual project. In case of absence, lectures can be compensated by a literature assignment and written report, and the individual project can be presented on a later occasion. Number of students: 5 - 12 Selection of students: Firstly, according to how relevant the course is to the student's project Secondly, according to registration date as PhD student at KI More detailed information: The course is aimed at the beginner, and requires no background in programming. Some experience using computers for mathematical calculations (Matlab, Mathematica, Excel) may be useful. The course will be held at the Karolinska Institutet campus in Solna. - 12 Course responsible Sten Linnarsson Scheeles väg 1 08/52487577
[email protected] MBB Department of Medical Biochemistry and Biophysics
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Course contact Sten Linnarsson Scheeles väg 1 08/52487577
[email protected] MBB Department of Medical Biochemistry and Biophysics
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Title: Ethics in global and public health research Course number: 2216 Credit points: 1.5 Date: 2009-05-04 - 2009-05-08 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Included in postgraduate course programme: World Health Learning outcomes: After the course, students will be able to: Identify ethical issues, problems and conflicts in global and public health research; Examine the ways in which ethical issues in those areas are either like or unlike ethical issues in other health sciences; Provide a decision making procedure for addressing ethical issues, problems and conflicts; Grasp the links between sound science and ethically and socially responsible science. Contents of the course: General The course will present the current core values in the conduct of research involving human subjects in a historical perspective. Specific Moral foundations Duties, responsibilities and practice standard Valid consent and refusal Privacy and confidentiality Risks, harms and wrongs Sponsorship and conflict of interest Information, communication, publication, intellectual property and education Advocacy and intercultural conflict Type of teaching: The course is held full time, during daytime, on five consecutive days. It follows a pre-established course schedule based on lecturers, seminars and plenary sessions after individual and group work. A variety of cases serve as a basis for the individual and group work. Examination: ndividual writing (identification and discussion of specific ethical dilemmas). Critical review of the dilemmas of others. Compulsory parts: The particiapnts are expected to take part in the lecturers and seminars each day. Those who do not attend will have individual reading assignments for which written summaries will be requested. Number of students: 15 - 25 Selection of students: PhD students registered at KI that are involved in research on global and public health issues will be given priority. More detailed information: - 25
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Course responsible Lucie Laflamme Nobels väg 9 5248 3372
[email protected] K9 Department of Public Health Sciences Course contact Gunilla Risberg Nobels väg 9 17177 Stockholm 4685283349
[email protected] International Health Department of Public Health Sciences
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Title: Qualitative Research Analysis Course number: 2217 Credit points: 1.5 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Learning outcomes: At the end of the course the students should be able to: Define dicourse and thematic types of analyses and explain their theoretical framework. Appraise the comparative advantages of both discourse and thematic analyses and determine when to use either of them for their qualitative articles. Analyze their qualitative data using any of these two types of analysis. Contents of the course: The course is divided into two modules , each module is dived into three topics. Module 1. Discourse Analysis: Topic 1. Theoretical framework Topic 2. Branches of discourse analysis Topic 3. Doing qualitative discourse analyses Module 2. Thematic Analysis: Topic 1. Inductive versus theoretical, realist versus constructionis thematic analysis Topic 2. Developing Themes and Codes Topic 3. Challenges in Using Thematic Analysis Type of teaching: Lectures Small group work Interactive seminars Practical individual assignements on the use of two types of analysis Examination: (i)A timed written individual examination to asses the cognitive level of knowledge of both discourse and thematic analyses of qualitative data. (ii)Assessment of the practical assignments to evaluate the task performance level of the students Compulsory parts: Attendance in seminars and class discussions is an integral part of the learning activities and therefore mandatory for all the participants. Inevitable absence can be compensated by taking home a written assignment on what has ben covered in class in the absence of a student. Number of students: 15 - 25 Selection of students: Priority will be given to students who have passed a basic qualitative research methods course and give a motivation for the need of this course. More detailed information: - 25 Course responsible Anne Kubai 178 of 227
Nobelsväg. 9 0852483371 anne.kubai.ki.se Department of Public Health Sciences Course contact Gunilla Risberg Nobels väg 9 17177 Stockholm 4685283349
[email protected] International Health Department of Public Health Sciences
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Title: Modern methods for DNA sequencing. Course number: 2218 Credit points: 1.5 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Department of Cell and Molecular Biology Included in postgraduate course programme: Cell Biology and Genetics Learning outcomes: After the completed course, the students will be able to understand and describe the technology behind the major DNA sequencing platforms available today, their strengths and limitations. Furthermore, the students will be able to describe the most important applications and relate and apply them to the students' own research. Contents of the course: The course covers the following topics: The history of DNA sequencing. Introduction to modern DNA sequencing. Practical considerations, cost and dealing with a deluge of data. Applications: RNA sequencing, ChIP sequencing and metagenomics. Future technologies and applications. Type of teaching: The learning activities on the course consist of lectures by invited speakers, and a site visit to a sequencing laboratory. In addition, the students will be supervised in the preparation of presentations on modern DNA sequencing methods to benefit their own research. Examination: Oral examination in conjunction with the presentation of individual student projects. Compulsory parts: All lectures are compulsory. Absence from the obligatory moments is compensated according to the instructions of the course director. Number of students: 5 - 10 Selection of students: The selection is based on the relevance of the course content for the PhD project and the personal motivation letter to attend the course. More detailed information: The course is organized at the KI Solna Campus. The course director is Dr. Sten Linnarsson (MBB) and the main examiner is Dr. Rickard Sandberg (CMB). - 10 Course responsible Sten Linnarsson Scheeles väg 1 08/52487577
[email protected] MBB Department of Medical Biochemistry and Biophysics Course contact Inger Westin 180 of 227
Box 285 Karolinska Institutet 17177 Stockholm 08-52487371
[email protected] Department of Cell and Molecular Biology
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Title: Bioinformatics for cell biologists Course number: 2219 Credit points: 1.5 Date: 2009-05-25 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department of Cell and Molecular Biology Included in postgraduate course programme: Cell Biology and Genetics Learning outcomes: After the completed course, the students will be able to utilize basic bioinformatics resources and tools, apply and integrate current, advanced computational biology methods in their research, and to make use of publicly available genome-wide sequencing data sets. Contents of the course: The course covers the use of most common bioinformatics resources such as public data bases and tools for sequence analysis. Practical excercises and discussions bridge sequence analysis to cellular function. Type of teaching: The learning activities on the course consist of lectures and practical computer excercises. In addition, the students will be supervised in the preparation of presentations on bioinformatics to benefit their own research. Examination: Formative examination with practical computer excercises. Summative oral examination in conjunction with the presentation of individual student projects. Compulsory parts: The computer excercises are obligatory. Absence from the obligatory moments is compensated according to the instructions of the course director. Number of students: 10 - 12 Selection of students: The selection is based on the relevance of the course content for the PhD project and the personal motivation letter to attend the course. More detailed information: The course provides essential, practical knowledge about computational methods in biology with focus on developmental biology. The course is organized at the KI Solna Campus. The course director is Dr. Rickard Sandberg (CMB). The course is organized in collaboration with DBRM (www.dbrm.se), Dr. Carsten Daub (RIKEN in Yokohama) and Ms Yun Ping Lim (Singapore). - 12 Course responsible Rickard Sandberg Berzelius väg 35 08-52483986
[email protected] Department of Cell and Molecular Biology Course contact Inger Westin Box 285 182 of 227
Karolinska Institutet 17177 Stockholm 08-52487371
[email protected] Department of Cell and Molecular Biology
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Title: Membrane protein structure and function Course number: 2221 Credit points: 1.5 Date: 2009-05-04 - 2009-05-08 Språk: english Level: Forskarnivå Responsible department: Department of Biosciences and Nutrition Learning outcomes: After the course the student will: updated on the current research on membranes and membrane proteins. be able to critically evaluate literature in this field and relate the concepts conveyed to their own research. Contents of the course: Membrane proteins are estimated as 20-30% of a genome, about 50% of available drugs are directed to GPCR:s the largest family of membrane proteins in humans and less than 1% of the protein structures in the protein data bank are membrane proteins. Apparently they are difficult to work with, why? We will look at the composition and dynamics of membranes and insertion and folding/assembly of membrane proteins. Also expression and purification problems will be highlighted. The main method of structure determination is with X-ray but also with electron crystallography and NMR. How do these methods apply to and compare for membrane proteins? We will look into this. When it comes to function we will look into how function relates to structure and structural changes. Structures of several medically important membrane protein families are available and will be highlighted to illustrate the topics above. Type of teaching: The course will consist of 5 full days of lectures, seminars, project work with individual presentations on the last day Examination: Presentation of the individual project Compulsory parts: Lectures, seminars and project work are compulsary. Absence would have to be discussed with the course leader. Number of students: 5 - 16 Selection of students: Field of interest stated in application and date of reg as a Ph.D student More detailed information: - 16 Course responsible Caroline Jegerschöld Hälsovägen 7, 141 57 Huddinge 08 6089199
[email protected] BioNut Department of Biosciences and Nutrition
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Title: Respiratory function: Assessment and treatment methods in ENT and SLP Course number: 2222 Credit points: 3.0 Date: 2009-03-02 - 2009-05-08 Språk: english Level: Forskarnivå Responsible department: Department for Clinical Science, Intervention and Technology Included in postgraduate course programme: Hearing, Otorhinolaryngology, Speech and Language Learning outcomes: After completing the course, the student is expected to be able to: -Extensively describe different assessment methods related to respiration and be able to interpret and analyse test results. -Extensively describe the role of respiration in different activities such as coughing/mobilization of secretions, swallowing as well as voice and speech production. -Relate these different activities to impaired respiratory function as seen in different kinds of respiratory disease, neurological disease affecting respiratory function as well as other congenital or acquired anatomical upper respiratory malformations. -Extensively describe, evaluate and compare surgical procedures and mangagement in tracheotomy as well as different types of cuffs and speaking valves used by individuals with tracheostomy. -Discuss and evaluate newer interventions in which breathing techniques are included in the treatment of voice, speech and swallowing disorders, as well as in speech and voice interventions for the hearing impaired and for individuals with cochlear implants, CI. Contents of the course: -Repetition of respiratory physiology (lower and upper respiratory tracts). -Assessment of respiratory function and interpretation of test results (e g nasometry, spirometry, respiratory muscle strength, blood gases etc). -The disease panorama in respiratory dysfunction (lower and upper airway disease, neurological disease etc). -Speech breathing (normal and impaired) in neurological disease, laryngectomy, functional and organic voice disorders, with focus on current research. -Acoustic, aerodynamic and perceptual assessment methods in speech breathing. -Overview of treatment interventions related to speech breathing (e g Expiratory Muscle Strenght Training (EMST), Inspiratory Muscle Strenght Training (IMST), Glossopharyngeal Insufflation assisted Training (GIaT), Continuous Positive Airway Pressure (CPAP). -Interventions related to breathing in rehabilitation of speech in hearing impairment and speech in individuals with cochlear implants, CI. Type of teaching: Lectures, laboratory demonstrations, literature seminars and individual/group assignments. Examination: Written assignment (case study where assessment methods and possible interventions have to be suggested and discussed in light of current research). Assignments will be presented in a seminar and each student will also have to review a project from a fellow student. Compulsory parts: Laboratory demonstrations and literature seminars are compulsory and will have to be rescheduled in case of 185 of 227
absence. Some lectures and the final seminar are also compulsory and if the student is absent a written account of the content has to be submitted. Number of students: 10 - 20 Selection of students: Priority is given to students who are registered doctorate students in the research area of the doctoral programme HÖST (Hearing, Otolaryngology, Speech and Language) More detailed information: The course will include lectures, seminars and laboratory demonstrations, mainly at Karolinska University Hospital, Huddinge. The course consists of an intensive course period (8 days) in March and follow up/examination in May (2 days). - 20 Course responsible Ellika Schalling B69, Karolinska university hospital, Huddinge 14186 Stockholm +46 (0)858587411 ellika.schalling@ki Div of Logopedics and Phoniatrics Department for Clinical Science, Intervention and Technology
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Title: Hearing and hearing disabilities - with focus on working life Course number: 2223 Credit points: 3.75 Date: 2009-03-23 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department for Clinical Science, Intervention and Technology Included in postgraduate course programme: Hearing, Otorhinolaryngology, Speech and Language Learning outcomes: Learning outcomes After completing the course, the student should be able to; - Relate congenital forms of hearing loss to the function/dysfunction of different genes, as well as to genetic and fenotypical heterogeneity - Derive the aetiology of different audiological disorders at all levels of the auditory and vestibular systems and also be able to analyse differences between these disorders, - Extensively describe, evaluate and compare different examination methods and treatments of different audiological disorders, - Extensively describe, evaluate and analyze prevention measures and strategies for hearing loss and hearing difficulties in working life. - Have a deeper understanding and knowledge about noise regulations and hearing conservation in different work life settings. - Discuss and reflect on difficulties, consequences and coping strategies for hearing impaired in different work life settings. - Discuss and analyze the background and possibilities of possible future treatments of hearing loss, - Discuss and evaluate the latest research in the field of hearing loss and hearing disabilities in working life Contents of the course: The course is an in-depth course within hearing diagnostics, hearing loss and medical audiology. Special focus will be on causes, prevention and coping of hearing disabilities in working life including regulations and hearing conservation programs. The course includes aetiology, medical background and treatments of different audiological och otoneurological conditions. Genetics and hereditary hearing impairment are also discussed in depth. Methods used in measurement of hearing loss are discussed, as well as the influence of noise and ototoxic agents on the auditory system. The course include current research on future possible treatments such as antioxidants, gene therapy and stem cell research. Prevention of damage from different ototoxic agents and acoustical trauma is considered. Type of teaching: The course will start with distance learning with given instruction of preparations for oral presentations of the course litterature in seminars during the course week. Lectures, seminars and demonstrations will take place during a concentrated period and after this period written assignements will be accomplished on distance. Examination: A written assignment formed as a systematic review on a chosen subject will test the students ability to evaluate, compare and analyze new research data together with basic knowledge. The assignmen will be presented orally on a examination seminar at the end of the course. A shorter written examination will test the overall knowledge. Compulsory parts: 187 of 227
Seminars and some lectures are compulsory. If students are absent from compulsory lessons the student have to give account for the contents of the lesson. Number of students: 6 - 25 Selection of students: Priority is given to students who are registered doctorate students in the research area of the research education programme (HÖST). More detailed information: The course will start with distance learning with given instruction of preparations for oral presentations of the course litterature in seminars during the course week. Lectures, seminars and demonstrations will take place during one concentrated week and after this week written assignements will be accomplished on distance. The course will end with an examination seminar. The lectures and seminars will take place at Karolinska Institutet in Huddinge and Solna between 2009-0420¿200904-25 The examination seminar will take place on 2009-05-15 - 25 Course responsible Ann-Christin Johnson Enheten för Audionomi 08-524 889 57
[email protected] Department of clinical science, intervention and technology, CLINTEC (H9) Department for Clinical Science, Intervention and Technology
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Titel: Att beforska svåråtkomliga studieområden inom vård och omsorg Kursnummer: 2224 Antal högskolepoäng: 3.0 Datum: 2009-03-01 - 2009-05-01 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för neurobiologi, vårdvetenskap och samhälle Ingår i forskarutbildningspprogram Vård och Omsorg Kursens lärandemål: Studenten skall efter genomgången kurs kunna analysera en svårbeforskad forskningfråga/plan inom vård och omsorgsområdet och tillämpa olika etiska och vetenskapsteoretiska perspektiv samt analysera forskningsfrågans metodologiska konsekvenser. Kursens innehåll: Svårbeforskade forskningsfrågor exemplifierade genom studier av människor med nedsatt kommunikationsförmåga, psykiska handikapp och icke kommunikativ förmåga - ur ett vetenskapsteoretiskt, forskningsmetodologiskt och forskningsetiskt perspektiv. Arbetsformer: Föreläsningar och seminarier med exempel på tillämpningar av olika etiska vetenskapsteoretiska perspektiv och metodologiska konsekvenser på svårbeforskade forskningsfrågor inom vård och omsorgsområdet Examination: Individuell skriftlig examination där studenten analyserar en svårbeforskad forskningfråga/plan inom vård och omsorgsområdet och tillämpar några olika etiska och vetenskapsteoretiska perspektiv samt reflekterar över metodologiska konsekvenser Obligatoriska moment: Antal studenter: 10 - 20 Urval av studenter: Urval till kursen baseras på motivering att gå kursen Ytterligare information: Kursen kommer att ges vid Örebro Universitet och Mälardalens högskola med föreläsningar seminarier och ett avslutande examinationsseminarium . Ansvarig för kurstillfälle Lena von Koch Fack 23 200 141 Huddinge 070 513 30 55
[email protected] Sektionen för arbetsterapi Institutionen för neurobiologi, vårdvetenskap och samhälle
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Titel: Genusperpektiv i vård- och hälsovetenskaplig forskning Kursnummer: 2225 Antal högskolepoäng: 4.5 Datum: 2009-03-06 - 2009-05-26 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för neurobiologi, vårdvetenskap och samhälle Ingår i forskarutbildningspprogram Vård och Omsorg Kursens lärandemål: Efter genomgången kurs ska kursdeltagarna kunna tillämpa ett genusperspektiv i analys/reflektion av ett forskningsprojekt. Kursdeltagarna skall kunna beskriva en bred orientering i genusvetenskapens framväxt och översiktligt beskriva den teoretiska utvecklingen inom det genusvetenskapliga fältet. After participation in this course the student shall be able to apply a gender perspective in an analysis/reflection of or within a research project. Further, the participant shall demonstrate broad knowledge about the theory development in the field of gender studies. Kursens innehåll: -Utvecklingen från idéer om könsroller till dagens genusteorier. -Genusperspektivens betydelser inom vård- och hälsovetenskapliga ämnen. -Hur genusperspektiv kan användas analytiskt i olika delar av forskningsprocessen. -Sammanhängande genusteoretiska begrepp inom feministisk-, Queer- och mansforskning. - From sex role to gender theory, the development of gender research. - Gender perspectives within health care research. - Using gender perspectives in the research process. - Concepts in feminist, queer and CPMM-research. Arbetsformer: Kursen är organiserad i form av fem träffar över terminen, där föreläsningar varvas med seminarieaktiviteter. Till det kommer en träff för examination av kursen. Kursens totala omfattning är 4,5 poäng. I de poängen ingår aktivt deltagande vid alla fem tillfällena samt en avslutande examinationsuppgift som består av en muntlig presentation kring något av kursens teman, gärna med anknytning till någon fråga inom det egna avhandlingsprojektet. The course is organized in five course meetings, with lectures' and discussions, over the semester with an additional meeting for the examination. The course comprises in all 4.5 credits and active participant in all course meetings and an oral presentation about a relevant issue of the main content of the course is compulsory. Examination: Kursen examineras genom en individuell skriftlig uppgift från någon del av forskningsprocessen i det egna avhandlingsarbetet eller en genusbaserad reflektion av det egna pågående forskningsprojektet samt munlig redovisning av kurslitteraturen vid examinationsseminaret. I den skriftliga examinationsuppgiften demonstreras den analytiska tillämpningen av genusperspektivet, i den munliga beskrivs framväxt och teoriutveckling. 190 of 227
Examination will take place via an individual written paper by the participant about how a gender perspective could/can be used in the own research process and a verbal presentation of theory and development in the field of gender studies att seminars. Obligatoriska moment: Aktivt deltagande vid alla fem tillfällena samt en avslutande examinationsuppgift som består av en muntlig presentation kring något av kursens teman, gärna med anknytning till någon fråga inom det egna avhandlingsprojektet. All course meetings are compulsory. Vid frånvaro från de schemalagda kurstillfällena får deltagaren göra kompletterade seminarer eller övningsuppgifter. Absence from a course meeting will cause that a competition exercise must be made. Antal studenter: 10 - 20 Urval av studenter: Företräde ges till doktorander med forskningsområde inom vård och omsorgsforskning . Urvalet baseras på motivering att gå kursen. Ytterligare information: Undervisningen är förlagd till Mälardalens högskola, Eskilstuna och består av fem kurstillfällen fördelade över terminen och ett avslutande examinationsseminarium. Kursen ges 6/3, 13/3, 26/3, 23/4, 7/5 kl 9.15 -12 samt 26/5 kl 9.15-14.00. Ansvarig för kurstillfälle Lena von Koch Fack 23 200 141 Huddinge 070 513 30 55
[email protected] Sektionen för arbetsterapi Institutionen för neurobiologi, vårdvetenskap och samhälle
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Titel: Beteendebiologi med fokus på människan Kursnummer: 2226 Antal högskolepoäng: 1.5 Datum: 2009-01-26 - 2009-05-25 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för kvinnors och barns hälsa Kursens lärandemål: Efter genomgången kurs ska doktoranden ha en ökad kunskap om: - människans uppkomst och utveckling - vad evolution är och hur det går till - vad kultur är och hur kulturell evolution sker - hur genetisk och kulturell evolution kan förklara beteende - biologins syn på könsroller och partnerval - biologiska perspektiv på samarbete Kursens innehåll: Inom medicin ägnar man sig typiskt åt frågan om HUR människan fungerar. Denna kurs riktar sig till dem som vill veta mer om VARFÖR vi beter oss som vi gör. Kursen handlar om mänskligt beteende utifrån ett genetiskt och kulturevolutionärt perspektiv. Kunskaperna kommer att tillämpas på könsroller, partnervalsbeteende och samarbete. Vi kombinerar teori och diskussioner med eget arbete. I kursen ingår ett individuellt arbete där doktoranden har möjlighet att fördjupa sig i någon för kursen relevant fråga. Arbetsformer: Seminarier, föreläsningar, individuellt arbete, grupparbete. Examination: Individuell inlämningsuppgift och presentation. Obligatoriska moment: Eventuell frånvaro som medför att inlämningsuppgift eller presentation inte kan göras i enlighet med kusplanen kompenseras med inlämningsuppgift. Antal studenter: 10 - 15 Urval av studenter: a) Motiveringen till varför studenten vill genomgå kursen. b) Om halvtidskontroll har skett och när studeranden har för avsikt att disputera c) registreringsdatum Ytterligare information: öreläsare är Carl-Adam Wachtmeister som är disputerad beteendebiolog med närmare 15 års erfarenhet av forskning och undervisning om beteende hos människor och djur. Carl-Adam har under flera år föreläst och varit ansvarig för kurser i bland annat human beteendebiologi på Stockholms Universitet. Han har specialiserat sig på samarbete och kulturell förändring och arbetar nu som seniorkonsult både inom universitetsvärlden och företagsvärlden med regelbundna uppdrag för bl.a. Karolinska institutet och Stockholms universitet. Schema för kursen delas ut i samband med kursstart. Undervisningen är förlagd till den sista måndagen i månaden (v.5, v.9, v.14, v.18 och v.22) under kurstiden. Denna tid omfattar både schemalagt arbete i grupp och individuellt arbete. Ansvarig för kurstillfälle Kristina Gemzell Danielsson 192 of 227
Karolinska sjukhuset i Solna, WHO-center 08-517 79 539
[email protected] Institutionen för kvinnors och barns hälsa Kontaktperson för kurstillfälle Anna Hildenbrand Karolinska sjukhuset i Solna, C4U1
[email protected] Institutionen för kvinnors och barns hälsa
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Title: Child health and the environment Course number: 2227 Credit points: 1.5 Date: 2009-03-23 - 2009-03-27 Språk: english Level: Forskarnivå Responsible department: Institute of Environmental Medicine Included in postgraduate course programme: Environmental factors and health Learning outcomes: After the course the student shall have acquired knowledge and understanding of the specific susceptibility and exposure of the developing foetus, infant and child to environmental factors and the importance of modifying factors. The student shall also have acquired a professional attitude in interpretation of toxicological and epidemiological studies related to child health for use in health risk assessment. Contents of the course: The course will include specific environmental areas of high concern for child health in Europe, such as indoor environment, environmental tobacco, air quality, organic and metal pollutants, noise, and electromagnetic fields. In addition the course will give an overview of general child health and the importance of modifying factors such as nutrition and genetics. Attention will be given to the issue of the increased frequency of allergy disease among children and their susceptibility. The overarching theme of the course will be risk assessment of environmental factors and the course include a information and discussion about the role of health outcome and exposure monitoring and the European action plans for child health and environment. Specific examples of risk assessments, where child health are crucial, will be discussed. Type of teaching: The course consists mainly of lectures given by Swedish and international experts in specific areas. It also includes group work with tutoring related to the syntax of the given information in relation to risk assessment. This group works are presented orally and discussed. Examination: The examination is the presentation and discussion of group work. This is complemented by oral questioning for individual examination. Compulsory parts: Participation in the group work is compulsory. Absence can be compensated with an individual task. Number of students: 10 - 10 Selection of students: The selection will be based on quality and relevance of research project and description of the motivation to attend the course. More detailed information: The course is given daytime from 09:00 to 16:00 at the Institute of Environmental Medicine (IMM), Nobels väg 13, SOLNA The course will be given in collaboration with the EU-funded project RA-COURSES and international participants will also attend the course. The total number of students will be about 30. - 10 Course responsible Mattias Öberg Box 210 194 of 227
171 Stockholm 08-524 875 17
[email protected] Institute of Environmental Medicine Course contact Mattias Öberg Box 210 171 Stockholm 08-524 875 17
[email protected] Institute of Environmental Medicine
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Title: Genetic Epidemiology Course number: 2228 Credit points: 1.5 Date: 2009-02-16 - 2009-02-20 Språk: english Level: Forskarnivå Responsible department: Department of Medical Epidemiology and Biostatistics Included in postgraduate course programme: Epidemiology Learning outcomes: After successfully completing this course you as a student are expected to be able to: -Describe the basic organization of the human genome and the central dogma of eukaryote genetics. -Relate the concepts of meiosis, recombination, linkage and linkage disequilibrium to each other. -Draw conclusions about genetic influences from trait distributions in families and estimate the relative degree of genetic influences from twin correlation data. -Describe the principal differences between candidate gene approach and genome-wide association studies. -Explain the concept of genome-wide significance levels and the role of replication for genetic association studies. -Use internet databases to find positions of genetic markers and to identify suitable tag markers for candidate genes. Contents of the course: The course is about concepts and methods used in studies of genetic variation influencing disease and other phenotypes. It will cover basic genetic mechanisms and Mendelian inheritance, complex and quantitative trait inheritance, gene-discovery strategies with advantages and disadvantages. Primary focus is genetic association studies with study design and interpretation of results. Type of teaching: Lectures, group work, computer demonstration and home task. Examination: To pass the course, the student has to show that the learning outcomes have been achieved. Active participation in group work and group task assessments is required. One assessment of the learning outcomes consists of a written home exam, which students have one week to complete after the course end. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered Compulsory parts: Only the examination is compulsory. Number of students: 15 - 25 Selection of students: 1.Registered postgraduate students from KI 2.Registered postgraduate students from outside KI 3.Others Within each category, students will be prioritised according to the relevance of the course content for their research. This is a third level course, and students are required to have previous knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" (course 1577), "Epidemiology II: Design of epidemiological studies" (course 1622), "Biostatistics I: Introduction for epidemiologists" (course 1579) and "Biostatistics II: Logistic regression for epidemiologists" (course 1513). To be considered, students are advised to submit a completed application form. Please, give all information 196 of 227
requested, including a motivation why applying for the course as well as a description of current research and previous courses taken. More detailed information: More information will be on our webpagehttp://ki.se/ki/jsp/polopoly.jsp?d=14380&a=40967&l=en - 25 Course responsible Patrik Magnusson Box 281, 171 77 Stockholm +46 8 524 823 53
[email protected] Department of Medical Epidemiology and Biostatistics Course contact Marie Dokken Box 281, 171 77 Stockholm Stockholm +46852482341
[email protected] Department of Medical Epidemiology and Biostatistics
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Title: Introduction to processing and analysis of imaging data in SPM5 Course number: 2229 Credit points: 9.0 Date: 2009-02-16 - 2009-04-15 Språk: english Level: Forskarnivå Responsible department: Departement of Woman and Child Health Included in postgraduate course programme: The Neurosciences Learning outcomes: (1) The student shall master the basic concepts and tools SPM5 (as outlined in the course contents) and how these concepts are implemented and used in SPM5. (2) The student shall have acquired basic skills in processing neuroimaging data in SPM5 and how to evaluate the results. (3) The student shall understand how to do batch processing in SPM5. Contents of the course: SPM5 is a software package, which runs in the MatLab software environment, for analyzing structural and functional neuroimaging data (e.g., MRI, PET, EEG, MEG). This course will provide an introdution to SPM5 and how it is used to analyze MRI and PET data. The course will provide an introduction to image formats and format conversion, preprocessing (including motion correction, acquisition time correction, tissue segmentation, anatomical normalization, and spatial filtering), the general linear model framework (modeling, estimation, and inference), the multiple non-independent comparisons problem, smooth random field theory, non-parametric randomization procedures. Type of teaching: The course is organized as a series of lectures which cover basic concepts and tools in SPM5. An important part of the course is homework, consisting of simple execises in applying SPM5 to MRI/PET data, which the student is expected to devote a substantial amount of time. Examination: All practical exercises should be correctly solved to pass the course. Compulsory parts: The graduate students are assumed to take part in all parts of the course. If the student is ill or unable to take part, he/she should discuss with the course directors of how to compensate this. Number of students: 7 - 30 Selection of students: The primary selection criteria are 1) the usefulness of the course for the graduate student in his/her graduate work, 2) the motivation given in the application to the course. More detailed information: - 30 Course responsible Fredrik Ullén Neuropediatrics Q2:07, ALB 0851777355 198 of 227
[email protected] Departement of Woman and Child Health Course contact Fredrik Ullén Neuropediatrics Q2:07, ALB 0851777355
[email protected] Departement of Woman and Child Health
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Title: Phenotyping of genetically modified mice Course number: 2230 Credit points: 4.5 Date: 2009-05-11 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department of Cell and Molecular Biology Included in postgraduate course programme: Cell Biology and Genetics Learning outcomes: After the completed the students will be able to demonstrate basic skills in systematic and standardized phenotypic analysis of mutant (transgenic and knock in/out) mice, relevant aspects of mouse biology and physiology, strategies for developing GEM:s and specific challenges in the breeding of mice. Contents of the course: The course covers basic skills in systematic and standardized phenotypic analysis of mutant (transgenic and knock in/out) mice, relevant aspects of mouse biology and physiology, strategies for developing GEM:s and specific challenges in the breeding of mice. Basic techniques and methods for characterizing both simple parameters and more specialized functions (such as behaviour, cardiovascular physiology, neurobiology and developmental biology) will be covered. Aspects in animal welfare are included in the course. Practical demonstrations will cover necropsy procedures as well as techniques for blood sampling. The course participants will be offered opportunities to train in specific practical moments according to their individual project plans. Type of teaching: The learning activities on the course consist of lectures, practical excercises and demonstrations. During the course the participants will present their projects or field of interests in a short presentation. Examination: Formative examination with practical moments. Oral examination in conjunction with the presentation of individual student projects. Compulsory parts: Lectures, practical excercises and group projects are compulsory. Absence from the obligatory moments is compensated according to the instructions of the course director. Number of students: 20 - 30 Selection of students: The selection is based on the relevance of the course content for the PhD project and the personal motivation letter to attend the course. More detailed information: The aim of the course is to introduce the participants to systematic and standardized phenotyping of genetically engineered mice (GEM), thereby minimizing the number of animals required as well as providing more reliable research results. The course is organized at the KI Solna Campus. The course director is Dr. Johannes Wilbertz and the main examiner is Dr. Björn Rozell. The course is organized in collaboration with DBRM (www.dbrm.se). - 30 200 of 227
Course responsible Johannes Wilbertz Box 285 171 stockholm 46852487318
[email protected] Department of Cell and Molecular Biology Course contact Inger Westin Box 285 Karolinska Institutet 17177 Stockholm 08-52487371
[email protected] Department of Cell and Molecular Biology
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Titel: Från kritisk granskning till evidensbaserad vård Kursnummer: 2231 Antal högskolepoäng: 1.5 Datum: 2009-03-17 - 2009-03-31 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för klinisk forskning och utbildning, Södersjukhuset Kursens lärandemål: För att kunna ge och utveckla en högkvalitativ sjukvård är ett evidensbaserat förhållningssätt nödvändigt och även ett krav från många landsting. Efter genomgången kurs ska doktoranden: - Ha kunskap att formulera kliniska/vetenskapliga frågeställningar som låter sig besvaras av den vetenskapliga litteraturen. - Känna till uppbyggnaden och innehållet i de viktigaste kliniska och vetenskapliga databaserna. - Ha kunskap om viktiga och vanliga forskningsmetodologiska felkällor. - Ha färdigheten att göra databassökningar och att sammanställa och presentera resultat; förmåga att kritiskt granska, tolka och värdera framtagen information. - Ha ett förhållningssätt där framtagen information, via syntes av klinisk erfarenhet och faktiska omständigheter, kan appliceras i den kliniska verkligheten. Kursens innehåll: Vad är evidensbaserad medicin (EBM)? Frågeformulering. Deltagarna utformar egen fallpresentation. Informationskällor för EBM. Informationssökning. Kritisk granskning. Hur använda kunskapen på den enskilde patienten. Redovisning av enskilt arbete. Arbetsformer: Kursen omfattar föreläsningar, seminarier, eget arbete under handledning samt datasökning. Dessutom krävs inför kursstart litteraturstudier och frågeformulering. Examination: Individuell examination i form av strukturerad skriftlig dokumentation av egenarbete samt muntlig presentation av resultatet av framtagen information. Obligatoriska moment: Närvaro vid kursdeltagarnas frågeformulering dag 1 samt vid redovisningen av kursens egenarbeten dag 2. Skriftligt godkänt egenarbete enl. mall inlämnat inför dag 2. Frånvaro kan ev. kompenseras genom extra uppsamlingsträff. Antal studenter: 10 - 20 Urval av studenter: Doktorander med klinisk medicinsk erfarenhet ges företräde. En blandad sammansättning av yrken såsom läkare, sjuksköterska, paramedicinare m.m. efterstävas varför vid överfylld kurs prioritet ges till underrepresenterad yrkesgrupp. Vid många ansökningar görs urval efter datum för registrering inom varje yrkesgrupp. Ytterligare information: Kursen ges på svenska, på Södersjukhuset, i samarbete med biblioteket Södersjukhuset och omfattar en inledande heldag, som kräver vissa förberedelser av deltagaren, samt 2 veckor senare en avslutande halvdag där deltagarna redovisar det egenarbeten som gjorts i mellantiden. Ansvarig för kurstillfälle Johan Alm 202 of 227
Sachsska Barnsjukhuset, Södersjukhuset 11883 Stockholm 073-973 26 00
[email protected] Institutionen för klinisk forskning och utbildning, Södersjukhuset Kontaktperson för kurstillfälle Ola Olén Sachsska Barnsjukhuset, Södersjukhuset, 11883 Stockholm 070-3270974
[email protected] Institutionen för klinisk forskning och utbildning, Södersjukhuset
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Title: Sex differences of the brain- impact of genetics and epigenetics Course number: 2232 Credit points: 1.5 Date: 2009-05-04 - 2009-05-11 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: The Neurosciences Learning outcomes: (1) To acquire knowledge in the current concepts about sex differences in the brain and the underlying mechanisms. (2) To be able to design adequate studies inplementing aspects of sex differences in anatomy, function, pharmacological response and neurochemistry of the brain, in humans, as well as animals. (3) To be cabable to decide when the sex aspect can be neglected. (4) To develop new strategies and research designs to futher address possible influence of sex when trying to understand the endophenotype of various neuropsychiatric disorders. Contents of the course: (1) Series of lectures informing about the state of the art knowledge about sex differences in the brain and their inpact on physiology and pathophysiology of behavior. (2) Instructions in how to design own studies implementing sex and gender aspects. (3) Instructions for making own data bases with focus on sex differences in the brain. Type of teaching: SOLO taxonomi will be applied. The course is organized as a series of lectures which cover basic concepts of brain anatomy and function focusing on sexual dimorphism and the underlying mechanisms. Both animal and human data will be covered. An important part of the course is homework, litterature seminars, simple execises with neuropsyhological testing, laboratories showing meausrements of emotional perception and response, interpretation of brain imaging data - all illustrating sex differences. Examination: Written analysis of how sex aspects have been implemented in several research articles presented during the course. Presentation of design of own experiment future study with implementation of sex aspects, argumenting for different strategies. Critical discussion of another students presentation of experimental design. Compulsory parts: The graduate students are assumed to take part in the entire course. If the student is ill or unable to take part, he/she should discuss with the course directors. Number of students: 7 - 30 Selection of students: Priority will be given to students with least 120p in medicine, biology or psychology. Other selection criteria are 1) the usefulness of the course for the graduate student in his/her graduate work, and 2) the motivation given in the application to the course. More detailed information: - 30 Course responsible 204 of 227
Ivanka Savic-Berglund MR Center, KS 851776761
[email protected] Department of Clinical Neuroscience Course contact Fredrik Ullén Neuropediatrics Q2:07, ALB 0851777355
[email protected] Departement of Woman and Child Health
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Title: Introduction to cognitive neuroscience Course number: 2233 Credit points: 3.0 Date: 2009-01-28 - 2009-03-11 Språk: english Level: Forskarnivå Responsible department: Departement of Woman and Child Health Included in postgraduate course programme: The Neurosciences Learning outcomes: The course is primarily intended to give graduate students with a background in computational neuroscience or psychology a basic introduction to the biological cognitive neuroscience literature. The students shall be able to understand, present, and critically discuss scientific papers within cognitive neuroscience, both from the human and animal literatures. Contents of the course: A representative set of papers within cognitive neuroscience, both in terms of methodology and research questions, will be presented by the students and discussed critically under teacher supervision. Type of teaching: The course is organized as 4 teacher-led seminars (2-4 h depending on the number of students). In each seminar 2-6 (depending on the number of students) papers are presented by the students and discussed. In pedagogical terms, the course thus uses a combination of peer learning and teacher instruction where the contents of each paper, as well as the presentation, are critically evaluated in the group. Examination: Accepted oral presentation of one paper. To be accepted, the student should demonstrate (i) a good understanding of the presented study, both in terms of methodology and results; (ii) an adequate, critical discussion of the findings in relation to other literature; and (iii) good skills in oral presentation. These three points will be evaluated by the course examiners. Compulsory parts: Peer-learning and discussions of presentations in groups is an essential part of this course. Presence on seminars is therefore compulsory. In case of absence, a possible compensation will be discussed with the course leaders. Number of students: 5 - 18 Selection of students: The primary selection criteria are 1) the usefulness of the course for the graduate student in his/her graduate work, 2) the motivation given in the application to the course. More detailed information: The course will be given in the form of four teacher-led seminars every second week. Examinations will be performed jointly by Ullén and Krieger, who take main responsibilities for papers dealing with human and animal experiments, respectively. - 18 Course responsible Fredrik Ullén Neuropediatrics Q2:07, ALB 0851777355
[email protected] Departement of Woman and Child Health 206 of 227
Course contact Fredrik Ullén Neuropediatrics Q2:07, ALB 0851777355
[email protected] Departement of Woman and Child Health
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Titel: Management och forskning Kursnummer: 2234 Antal högskolepoäng: 3.0 Datum: 2009-02-12 - 2009-05-21 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för kvinnors och barns hälsa Kursens lärandemål: Efter genomgången kurs ska doktoranden ha: - teoretisk förståelse för hur vi påverkar de människor vi arbetar tillsammans med genom exempelvis vårt förhållningssätt och hur andra påverkar oss - praktisk erfarenhet av hur vårt kroppsspråk påverkar våra kollegor och andra människor i vår omgivning - förvärvat kunskaper om management och maktutövning ur ett historiskt perspektiv och vad vi kan förvänta oss av framtiden inom samma område - en djupare förståelse för de mekanismer som främjar respektive bryter ner samarbetet mellan individer eller inom en grupp - förståelse för moraliska överväganden i en ledarskapssituaion - tillägnat sig grunder i förhandlingsteknik - tagit del av erfarenheter från ledare både inom näringsliv och forskning Kursens innehåll: Under seminarieserien kommer ett antal talare med för kursen intressanta specialområden att tala om ämnen som management, ledarskap, relationsbyggande, samarbete och etik. Arbetsformer: Föreläsningar, interaktiva seminarier, praktiska övningar, samt att föra loggbok över seminarierna utifrån fördefinierade frågeställningar. Examination: Loggbok med reflektioner över seminarier och föreläsningar. Obligatoriska moment: Eventuell frånvaro som medför att loggboken inte är komplett kan kompenseras med inlämningsuppgift. Antal studenter: 10 - 20 Urval av studenter: a) Motiveringen till varför studenten vill genomgå kursen. b) Om halvtidskontroll har skett och när studeranden har för avsikt att disputera c) registreringsdatum Ytterligare information: Forskning sker idag i allt högre utsträckning i grupp och nätverk - både nationella och internationella. Forskningsledarens roll skiljer sig inte mycket från företagsledarens. Däremot försummas ofta utbildning på detta område i den annars mycket kunskapsintensiva forskningsvärlden. Syftet med denna seminarieserie är att inspirera till vidareutbildning och att skapa större insikter om de mekanismer som skapar mer framgångsrikt och effektivare socialt beteende både som forskningsledare och deltagare i en forskningsgrupp. Under seminarieserien kommer ett antal talare med för serien intressanta specialområden tala om ämnen som management, ledarskap, relationsbyggande, samarbete och etik. Föreläsare: Åsa Nilsonne ¿ föreläsning "Tillsammans - om medkänsla och bekräftelse" Psykiatriker, professor i medicinsk psykologi, psykoterapeut, handledare i kognitiv psykologi och författare till 208 of 227
ett antal böcker. Anders Wendelheim ¿ seminarium "Tillits- och öppenhetsspiral - om att skapa tillit och förtroende i en grupp" Fil dr i psykologi, universitetslektor vid psykologiska institutionen på Stockholms univeristet, konsult sedan 1987 och specialiserad på förändringsarbete och grupprocesser. Ian Wachtmeister ¿ föreläsning "Företagsledning och politiskt ledning" Företagsledare, företagsängel, författare, politisk debattör och f.d. partiledare och riksdagsman. Jan Söderqvist ¿ föreläsning "Framtidens ledarskap - nya trender inom ekonomi, företagande, politik, kultur och konsumtion - hur samtiden och framtiden formas av ny teknologi och interaktiv kommunikation" Författare, föreläsare, skribent (SvD) och konsult. F.d. TV-producent och redaktör på ett antal tidskrifter. Författare till böcker som ¿Nätokraterna¿ och ¿Det globala imperiet¿ (tillsammans med Alexander Bard). Johan Holm ¿ seminarium "Maktutövning och legitimitet ur ett historiskt perspektiv - sambandet mellan samarbete, ledarskap och maktutövning" Fil. dr i historia, föreläsare vid historiska institutionen vid Stockholms Universitet och gymnasielärare i filosofi, historia och samhällskunskap. Marc Bygdeman ¿ föreläsning "Min erfarenhet som forskare och kliniker vid KI och KS" Professor emeritus, fd chefsläkare, chef för WHO:s center för reproduktion vid KS, hedersledamot av Royal College of Obstetrics and Gynecology och American College of Obstetricians and Gynecologists och har tilldelats Kungens guldmedalj för sina insatser inom forskning och utveckling. M. Bygdeman är författare till drygt 400 vetenskapliga artiklar inom sitt ämnesområde. Sofia Czinkoczky ¿ praktiska övningar och improvisation "Social status och kroppsspråk" Skådespelare med stor erfarenhet av kurser i improvisationsteater och presentationsteknik. F.d. konstnärlig ledare på Stockholms Improvisationsteater. Sedan 1999 arbetar hon med utbildning och ger kurser i kommunikation, improvisation och kreativitet för företag. Carl-Adam Wachtmeister ¿ seminarium "Samarbetets mekanismer - ett nytt tvärvetenskpligt fält" Fil. dr i beteendebiologi, f.d. universitetslektor och forskare. Konsult specialiserad på ekonomisk psykologi och samarbete. Richard von Plauen ¿ seminarium "Hur bör jag leda - är det avsikten med eller konsekvenserna av min handling som räknas? Vilken information ska jag sprida i organisationen?" Civ. ek. från HEC i Paris, filosofi på Ecole Normale Supérieure. Lärare i filosofi vid Lycée Francais sedan 1997. Johan Lagerbielke ¿ "Förhandlingsteknik, relationsbyggande och kommunikation." Bakgrund som lärare och forskare i ekonomisk psykologi på Handelshögskolan i Stockholm. Civ.ek., MBA och fil.kand. i svenska och psykologi. Konsult sedan 1995 med inriktning på förhandlingsteknik och förändringsprocesser. Schema delas ut i samband med kursstart. Samtliga föreläsningar och seminarier kommer att vara på torsdag kvällar utspridda under vårterminen. Preliminära datum: 19 feb, 5 mars, 19 mars, 26 mars, 2 april, 16 april, 23 april, 30 april, 14 maj, 21 maj. Ansvarig för kurstillfälle Kristina Gemzell Danielsson Karolinska sjukhuset i Solna, WHO-center 08-517 79 539 209 of 227
[email protected] Institutionen för kvinnors och barns hälsa Kontaktperson för kurstillfälle Anna Hildenbrand Karolinska sjukhuset i Solna, C4U1
[email protected] Institutionen för kvinnors och barns hälsa
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Titel: Presentationsteknik med fokus på innehåll Kursnummer: 2235 Antal högskolepoäng: 3.0 Datum: 2009-01-23 - 2009-05-22 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för kvinnors och barns hälsa Kursens lärandemål: Efter genomgången kurs ska doktoranden: - tillägnat sig kunskaper i hur en presentation kan disponeras för att budskapet ska nå fram på ett framgångsrikt sätt - lärt sig att anpassa en presentation till en viss målgrupp - behärska grundläggande kunskaper i power-point-hantering - fått prova på att använda olika hjälpmedel i en presentation, som power point, whiteboard och blädderblock - kritiskt kunna granska den egna presentationen utifrån parametrar som textmassa, budskap, struktur, disposition, val av bilder etc Kursens innehåll: I kursen utgår vi ifrån doktorandens egna forskningsresultat och utifrån dessa skapas presentationer riktade mot olika målgrupper. Särskilt betonas vikten av att nå fram till den målgrupp presentationen är avsedd för, disposition, tidsskattning och tydlighet i budskapet. Det unika med denna kurs är att vi utgår från varje enskild deltagares behov och till stor del anpassar kursinnehållet utifrån detta. De kursdeltagare som så önskar kommer även att ha möjlighet att lära sig grunderna i power point. Arbetsformer: Examination: Presentationer. Obligatoriska moment: Eventuell frånvaro som medför att presentationerna inte kan göras tillsammans med andra kursdeltagare kompenseras med inlämningsuppgift. Antal studenter: 10 - 15 Urval av studenter: a) Motiveringen till varför studenten vill genomgå kursen. b) Om halvtidskontroll har skett och när studeranden har för avsikt att disputera c) registreringsdatum Ytterligare information: Kursen kommer att ges dagtid under ett antal fredagar under vårterminen (v. 5, v.7, v.9, v.11, v.13, v.15, v.17, v.19, v.21. (Det finns goda möjligheter att påverka det individuella schemat genom att i god tid lämna in önskemål vid förhinder eftersom en del av kursen ges i grupper som har undervisning på olika dagar.) Kursupplägget bygger på att du förbereder olika korta presentationer hemma eller under seminarietid, vilka vi sedan arbetar med på schemalagd tid. Dessutom finns det möjighet att delta i power point undervisning, vilken är indelad efter kunskapsnivå. En förutsättning för att kunna delta i kursen är tillgång till dator. Ansvarig för kurstillfälle Kristina Gemzell Danielsson Karolinska sjukhuset i Solna, WHO-center 211 of 227
08-517 79 539
[email protected] Institutionen för kvinnors och barns hälsa Kontaktperson för kurstillfälle Anna Hildenbrand Karolinska sjukhuset i Solna, C4U1
[email protected] Institutionen för kvinnors och barns hälsa
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Title: Scientifically evaluated interventions in suicide prevention Course number: 2236 Credit points: 1.5 Date: 2009-01-12 - 2009-01-16 Språk: english Level: Forskarnivå Responsible department: Department of Public Health Sciences Included in postgraduate course programme: World Health Learning outcomes: Upon completing the course the student should: (1) have in-depth knowledge of concepts and methods in research on the prevention of mental ill-health and suicide in populations and vulnerable population subgroups; (2) be able to critically reflect on the the relevance of different scientific subdisciplines and of quantitative and qualitative methods when planning, carrying out, and interpreting results in population-based research; (3) have presented his or her own research in a seminar and demonstrated an openness to discussing this work with a group of researchers in the field. Contents of the course: Prevention of mental ill health and suicide; scientific contributions to understanding sucide; methodological issues in mental health research. Type of teaching: Lectures, seminars with discussions of students' own projects Examination: In addition to participating actively in the course, each student is required to present his or her own ongoing or planned research in a seminar during the course week. Compulsory parts: All lectures and seminars are obligatory. Absence from a lecture or seminar may be compensated by a written assignment, on agreement with the course leader. Number of students: 8 - 20 Selection of students: Priority will be given to PhD-students (1) with experience from research or practical work in the mental-health field and (2) according to date of registration. More detailed information: Special focus 2009: Evidence in mental health research. Invited lecturerers: Prof em Rolf Sandell, Stockholm; prof. Lars Mehlum, Oslo; prof Merete Nordentoft, Copenhagen; prof Armin Schmidtke, Wuerzburg, Germany 20 Course responsible Danuta Wasserman NASP, KI, 1771 77 Stockholm 08-524 869 37
[email protected] Department of Public Health Sciences
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Course contact Elizabeth Martenson NASP, Karolinska Instiutet, 171 77 Stockholm 852487793
[email protected] Department of Public Health Sciences
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Title: The psychobiology of emotions Course number: 2237 Credit points: 4.5 Date: 2009-04-01 - 2009-05-15 Språk: english Level: Forskarnivå Responsible department: Department of Clinical Neuroscience Included in postgraduate course programme: The Neurosciences Learning outcomes: (1) The student shall have acquired a good understanding of the concept emotion as discussed in psychology and biology. (2) The student shall be able to discuss the application of emotion research to relevant issues in clinical and healthy interpersonal contexts. (3) The student shall have developed an in-depth understanding of a selection of topics related to the forefront of research on the biology of emotions. Contents of the course: The course focuses on the rapidly growing knowledge of the biological bases of emotion and how this knowledge affects our understanding of both clinical and normal aspects of human behavior and psychology. The course consists of two consecutive blocks. The first block lays the ground for a good conceptual understanding of theoretical and empirical perspectives of emotion and how it can be applied to phenomena on both individual and group level. The second block provides the opportunity to gain an in-depth understanding of a selection of research topics drawn from current research of the biology of emotion (e.g. fear and phobias, empathy, emotional regulation, and emotion and consciousness). Type of teaching: The course is organized as a series of lectures and seminars that runs across the two blocks. Examination: The course is examined in three ways: (1) active participation in the seminars; (2) two short papers that summarize and critically discuss two relevant topics from the course; and (3) one research proposal outlining an experiment related to the theme of the course. Compulsory parts: The graduate students are assumed to actively participate in both lectures and seminars. If the student is ill or unable to take part, he/she should discuss with the course directors of how to compensate this. Number of students: 7 - 30 Selection of students: The primary selection criteria is the usefulness of the course for the graduate student in his/her graduate work More detailed information: Several of the lectures will be given by invited speakers - 30 Course responsible Arne Öhman Psychology Section 08-524 824 56; 08-524 824 59
[email protected] Department of Clinical Neuroscience 215 of 227
Course contact Andreas Olsson Psychology Section 08-524 824 59
[email protected] Department of Clinical Neuroscience
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Title: Systems Biology and the Omics Cascade Course number: 2238 Credit points: 1.5 Date: 2009-05-25 - 2009-05-29 Språk: english Level: Forskarnivå Responsible department: Department of Medical Biochemistry and Biophysics Learning outcomes: Following successful completion of the course, the student will acquire a basic level of knowledge regarding systems biology and different omics-related technologies used in the acquistion of large-scale datasets. In addition, students will be updated on recent findings within these fields. Specifically, students will be able to: Reflect on the utility of omics-related research in terms of hypothesis generation and experimental design. Relate to principle the appropriate applications of different computer programming languages and algorithms. Theorize on the future development of omics-related research approaches and systems biology, as well as motivate the answer. Contents of the course: This course will provide students with a broad spectrum overview of the field of systems biology and present the different technologies and methods employed in this type of research approach. Specific aims include the following: Convey to students the concept and rationale behind systems biology and omics-related research approaches and experimental design. Provide an overview of available web-based databases, including KEGG, Reactome database, GenBank, PDB, UniProt, EBI, MIPS, and GO. Explain the strengths and weaknesses behind different computer programming languages and the appropriate applications, including Perl, R, Bioruby, etc. Educate students on the current state of systems biology and potential future research directions to assist students in applying these methods to their research. Type of teaching: The course will employ a combination of teaching resources including lectures, laboratory exercies and seminars. A significant portion of the course will focus on hands-on learning using computers in the presence of instructuors and IT-personel. Examination: Satisfactory completion of the course will be assessed by written examination consisting of a research report on an aspect of systems biology. This exact subject of the report may be chosen by the student, but must be approved by the course organizer. The final report must be 3 A4 pages or less (12 point font, 2.54 cm margins) including references and must be turned in within 2 weeks of course completion in order to receive course credit (there is no minimum length). The report should make use of the journal articles and concepts discussed during the course, which are expected to generate ideas for the reports. In the event of an unsatisfactory report, as determined by the course organizer, the student will be given one additional week to re-write and resubmit the report. Compulsory parts: Attendance at all laboratory sessions is required. In the case of necessary absence, the student will be required to perform the laboratory exercises outside of class before a grade is issued. Number of students: 15 - 30 217 of 227
Selection of students: Priority will be given to students with familiarity with computer-based research approaches and who demonstrate a pressing need for the course material. More detailed information: The aim of the course is to provide students with a broad spectrum overview of the field of systems biology and present the different technologies and methods employed in this type of research approach. Specific aims include the following: Convey to students the concept and rationale behind systems biology and omics-related research approaches and experimental design. Provide an overview of available web-based databases, including KEGG, Reactome database, GenBank, PDB, UniProt, EBI, MIPS, and GO. Explain the strengths and weaknesses behind different computer programming languages and the appropriate applications, including Perl, R, Bioruby, etc. Educate students on the current state of systems biology and potential future research directions to assist students in applying these methods to their research. - 30 Course responsible Craig Wheelock Scheeles vag 2 08 5248 7630
[email protected] Department of Medical Biochemistry and Biophysics Course contact Craig Wheelock Scheeles vag 2 08 5248 7630
[email protected] Department of Medical Biochemistry and Biophysics
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Title: Multi- and mega variate analysis in omics research Course number: 2239 Credit points: 1.5 Date: 2009-02-09 - 2009-02-13 Språk: english Level: Forskarnivå Responsible department: Department of Medicine, Solna Learning outcomes: Following successful completion of the course, the student will acquire a basic level of knowledge regarding multivariate analysis of large-scale datasets aquired in omics research, and be proficient enough users to be able to put them to use in their own research projects. Specifically, students will: ¿Have knowledge on how to use and interpret PCA and OPLS-DA models in Omics studies as well as for classification ¿Have knowledge of how to apply multivariate tools for putative biomarker identification ¿Understand how to compare multiple treatments, and understand the importance of uncorrelated information ¿Be able to apply PCA to detect outliers, trends, patterns and to classify groups within complex data ¿Be able to relate multiple responses to multiple inputs using PLS (Partial Least Squares) modeling ¿Be able to analyze experimental data using sound statistical principles ¿Have gained basic competence in how to use the SIMCA software for MVA, including reporting results in simplified graphical formats ¿Be able to reflect on the utility of multivariate methods in experimental design ¿Be able to theorize on the principles of multivariate data analysis, specifically in the filed of systems biology, as well as motivate the answer. Contents of the course: Modern data sets contain many variables where the most interesting trends are hidden within a combination of the variables. Omics related data sets are characterized by thousands of variables (e.g. genes or proteins) being analyzed simultaneously with very few replicates. The difficulties in extracting relevant trends are thus amplified by the high number of false positives produced when using traditional univariate statistical methods for these types of data sets. As such, multivariate data analysis (MVA) is essential in the process of extracting information from the complex data sets involved in Omics studies. In this course, participants will learn how to interpret complex data sets quickly and confidently by use of the latest multivariate techniques. The students will learn how to build valid and robust predictive models based on data from transcriptomic, proteomic and metabolomic studies, and discover the secrets of overviewing data. In addition, participants will learn how to use state-of-the-art multivariate tools to extract putative biomarkers or other relevant findings in a statistically significant way. As an additional module, the course will provide basic insight into how MVA can be used for design of experiments for optimization of the effect of experimental variables, and thereby minimize time and resources spent in the laboratory. These increased throughput and reliability of the experimental outcome will be demonstrated through hands-on analysis of real data using the software package MODDE. Type of teaching: The course is composed of lectures, demonstrations and computer exercises using SIMCA-P+12 software on real-life datasets, which will illustrate the principles and practice of MVA. Each day of the course is divided into a morning and an afternoon session. Every session will start with a theoretical lecture followed by practical, real-life exercises using the SIMCA or MODDE software. During the 219 of 227
practical sessions, the students will have the possibility to work on their own data sets under guidance of the instructors to assure that the knowledge gained during the course will come into practical use in their own research. The course will employ a combination of teaching resources including theoretical lectures and laboratory exercies. A significant portion of the course will focus on hands-on learning using computers in the presence of instructors and IT-personel. Examination: The course examination will consist of a written report of a MVA analysis performed on the student's own data sets (if own data set not are available, they can be provided by the course instructor). The data set and choice of analysis method must be approved by the course organizer. The final report must be 3 A4 pages or less (12 point font, 2.5 cm margins) including references and must be turned in within 2 weeks of course completion in order to receive course credit. The report should be based on analyses performed with the SIMCA software during the course, and discuss the results in the light of the the concepts discussed in the course as well as in comparison to traditional analysis methods used in the relevant field of research. In the event of an unsatisfactory report, as determined by the course organizer, the student will be given one additional week to rewrite and resubmit the report. Attendance at all laboratory sessions is required, as satisfactory completion of the course will also be assessed by completion and understanding of in-course computer exercises. Compulsory parts: The focus will be on practical applications and development of own software skills, and attendance on all computer laboratory sessions is mandatory. In the case of necessary absence, the student will be required to perform the laboratory exercises outside of class before a grade is issued Number of students: 12 - 20 Selection of students: The selection of course participants will be based on the motivation that the applicant hands in at the time of application. Familiarity of Omics research approaches is a merit. More detailed information: The aim of the course is to provide students with an overview of the methods available for multi- and megavariate data analysis, with specific focus on practical aspects of analysis of omics-related research using the Simca P+ software. Specific course aims include: ¿Educate students on the theoretical aspects of state-of-the-art multivariate methods used in omics research, including principal component analysis (PCA) and Orthogonal Projections to Latent Structures (OPLS) ¿Explain the strengths and weaknesses with multi- and mega variate analysis methods as compared to standard univariate methods ¿Convey to students how PCA and OPLS can be used in practical applications to detect outliers, trends and patterns, and otherwise to interpret models to gain scientific insights ¿Provide the students with practical experience in using MVA tools for putative biomarker identification, comparison of multiple treatments, and validation of models for robustness and predictability Tentative Schedule for Spring 2009 (Feb 9-13): Place: Karolinska campus Solna Monday AMIntroduction to multivariate data analysis (Theoretical). PMGeometric representation of multivariate data. Problems with classical approaches. Principal component analysis (PCA) to identify trends and for outlier detection. (Theoretical and practical) Tuesday AMPartial Least Squares (PLS): prediction of responses Y from control parameters X. Variable scaling, geometrical interpretation, algebraic solution and model evaluation. (Theoretical and practical) PMMultivariate characterization: quantification of qualitative or discrete differences, such as change of batches, raw material, chemicals or suppliers. (Theoretical and practical) Wednesday AMMultivariate analysis of Omics data sets. (Theoretical and practical) PMPractical data processing, scaling and normalization. Analysis of own data sets. (Theoretical and practical) 220 of 227
Thursday AMFrom PCA to Orthogonal Partial Least Squares (OPLS) in Omics data sets. Finding information between X and y. The meaning of uncorrelated information. Model classification and diagnostics by OPLS discriminant analysis (DA). (Theoretical and practical) PMPotential biomarker identification using the S-plot. What to report about biomarkers. Comparing multiple treatments using the SUS-plot. Model validation. Analysis of own data sets. (Theoretical and practical) Friday AMHow and when should design of experiments be used? Problem formulation, selection of goals, factors, responses, type of model and design. Analysis of full factorial designs, evaluation of raw data, regression analysis and model interpretation. (Theoretical and practical) PMScreening designs; which factors dominate and what are their optimal ranges? Optimizing designs; how do we find an optimum or a compromise? Robustness testing, verification that the method or process is robust within given specifications. (Theoretical and practical) - 20 Course responsible Åsa Wheelock Lungforskningslab L4:01 Karolinska sjukhuset 08-517 76557
[email protected] Enh. för lungmedicin Department of Medicine, Solna Course contact Åsa Wheelock Lungforskningslab L4:01 Karolinska sjukhuset 08-517 76557
[email protected] Enh. för lungmedicin Department of Medicine, Solna
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Title: Cancer proteomics Course number: 2241 Credit points: 3.0 Date: 2009-03-09 - 2009-03-20 Språk: english Level: Forskarnivå Responsible department: Department of Oncology-Pathology Included in postgraduate course programme: Tumour Biology and Oncology Learning outcomes: - Student should be able to use commonly used protomics terminology and explain principles of widely used proteomics methods. -Student should acquire general understanding of components of the proteomics research process such as study design, sample preparation, selection of technologies and data analysis and interpretation -The student should understand proteomics to such extent that he/she will be able to take advantage of proteomics core facilities or collaborate with proteomics researchers. The student should be able to give examples how modern proteomics is applied to cancer research and to evaluate when proteomics research could be beneficial to incorporate in a research projects. Contents of the course: Course contains introduction to mass spectrometry and widely used proteomics methods: two dimensional gel electrophoresis, quantitative proteomics by mass spectrometry, tissue micro array. Proteomics related bioinformatics part include introduction to relevant statistics used for study planning and data-analysis as well as down stream data-analysis tools such as multivariate data analysis and pathway analysis. Current state of art in cancer proteomics is highlighted through case lectures, literature study and demonstrations. Type of teaching: 1. The course contains lectures on proteomics methods including mass spectrometry, two dimensional gel electrophoresis and tissue micro array. 2. The current cancer proteomics research is introduced by literature review and discussions as well as cancer proteomics research seminars. 3. Course contains also laboratory demonstration of proteomics methods. Examination: Course examination is composed by two parts: Assignment 1: Return the literature/expert group discussion questions in writing and present the topic area in a 15 minutes presentation as examination part 1. Assignment 2: Written exam where students will describe a proteomics project (beneficially related to their PhD-research) including different aspects from the proteomics workflow. Compulsory parts: Attendance to examination seminar and hand in the written examination assignment is compulsory. Extra written litterature study can be used to compensate absence. Number of students: 10 - 24 Selection of students: Letter of intent More detailed information: Course will include interesting lectures from leading scientist in the field, discussion and demonstrations to get 222 of 227
inside to cutting edge proteomics. Course is distributed over two weeks time as follows: Week 1: Mon-Wed, active participation on lectures and workshop; Thu-Fri, own time to work with literature study; Week 2: MonWed, active participation on lectures and workshop, To-Fre, time to work on examination assignment. - 24 Course responsible Janne Lehtiö Z5:02 KBC Karolinska Universitetssjukhuset, Solna 171 Stockholm 08-51776391
[email protected] Department of Oncology-Pathology Course contact Helena Bäckvall Z5:02 KBC Karolinska Universitetssjukhuset 171 Stockholm 08-51776347
[email protected] Department of Oncology-Pathology
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Titel: Tillämpad statistisk analys av longitudinella data * Kursnummer: 2242 Antal högskolepoäng: 4.5 Datum: 2009-03-23 - 2009-04-24 Språk: svenska Nivå: Forskarnivå Kursansvarig institution: Institutionen för lärande, informatik, management och etik Kursens lärandemål: Målsättningen är att deltagaren efter avslutad kurs skall kunna : 1. Förstå bakomliggande egenskaper hos longitudinella data 2. Identifiera en lämplig analysmetod efter frågeställning 3. Genomföra enkla såväl som komplexa statistiska analyser av longitudinella data 4. Presentera och förstå resultat av analys 5. Använda statistiska verktyg för analys och presentation (SPSS och AMOS) Kursens innehåll: Kursen behandlar moderna metoder att analysera longitudinella data. Typiska egenskaper i en longitudinell design är korrelation mellan mättillfällen, olika varians över tid, olika gruppvarianser och saknade värden. En metod att ta hänsyn till dessa egenheter är "linear mixed-effects models". I de flesta longitudinella studier mäts respons/utfall vid upprepade tillfällen, men de förklarande variablerna endast vid baseline. En annan typ av design är att mäta både utfall och en förklarande variable vid varje mättillfälle. Frågeställningen kan då vara om förändringen i utfallet påverkas av förändringen hos den förklarande variabeln. Kursen behandlar även denna typ av design. Kursen inleds med klassisk variansanalys (ANOVA) för att deltagaren skall få ett historiskt perspektiv på hur longitudinella data tidigare behandlats. I denna del av kursen behandlas också enklare metoder för longitudinell design (t ex arean under kurvan, AUC). Deltagarna får tillgång till material från ett antal studier. Detta tillsammans med artiklar utgör grunden för diskussion och praktiska övningar. En stor del av kursen kommer att ägnas åt ett projektarbete, där kursdeltagaren ges möjlighet att analysera sina egna data. Kursinnehållet kommer, i mesta möjliga mån, presenteras med statistikprogrammen SPSS och AMOS. Kursdeltagarna ges möjlighet att använda nämnda statistikprogram under övningstillfällena. Kursen är avsedd som tillämpad statistik. Kursinnehållet betonar därför principer och praktiska exempel istället för matematiska formler och teorem. Arbetsformer: Undervisningen kommer att bestå av 3-4 schemalagda heldagar per vecka under 3 veckor. Föreläsningar och seminarier varvas med praktiska övningar vid dator. Övrig tid ägnas åt inläsning av kurslitteraturen samt eget projektarbete. Examination: Godkänt projekt arbete. Muntlig presentation av projektarbete (inför övriga doktorander). I projektarbetet skall det framkomma att vald metod passar till frågeställning/design och att analysen är utförd på ett korrekt sätt. Godkända datorövningsuppgifter. Obligatoriska moment: Obligatorisk närvaro gäller vid alla seminarier och introduktionsföreläsningen. Om doktoranden inte kan uppfylla dess villkor så kommer han/hon få skriftliga hemuppgifter. Antal studenter: 15 - 20 224 of 227
Urval av studenter: Endast doktorander med grundkurs i statistik eller motsvarande antas. Urval till kursen baseras på den motivering som den sökande lämnar vid ansökningstillfället. Ytterligare information: Ansvarig för kurstillfälle Jakob Bergström LIME Berzelius väg 3, KS Huddinge Huddinge 08-524 837 14
[email protected] Institutionen för lärande, informatik, management och etik Kontaktperson för kurstillfälle Margareta Krook-Brandt Berzelius väg 3 Stockholm +46852487118
[email protected] Institutionen för lärande, informatik, management och etik
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