Farewell symposium Cornelis Jakobs November 25th, 2011 VU University Medical Center Amsterdam

INVITATION In honour of prof. dr. Cornelis Jakobs, who will reach emeritus status in January 2012, a symposium will be organised at the VU University Medical Center, Amsterdam on Friday November 25th, 2011:

“Farewell symposium Cornelis Jakobs” The symposium will follow this year’s SSIEM Academy Course also held in Amsterdam on November 23rd and 24th. For all participants of either occasion there will be a gettogether on the evening of November 24th. The farewell symposium will be followed by a reception. The organizing committee warmly invites you to attend the symposium on the 25th of November. We are pleased to announce the participation of a number of highly distinguished speakers, who will provide you with an inspiring view on the area of inborn errors of metabolism. Organising committee: dr. G.S. Salomons dr. H.J. ten Brink prof. dr. M.A. Blankenstein ms. A. Tekkelenburg (secretariat)

November 24th 2011 17.00 – 19.00 Get-together (Participants SSIEM Academy + Participants Farewell Symposium) Venue: To be announced

November 25th 2011

Symposium “Festschrift Cornelis Jakobs” Venue: Amstelzaal, VU University Medical Center Amsterdam, De Boelelaan 1117 I: Current highlights: Metabolic Laboratory, VUmc Chairman: Herman ten Brink / Peter Scheffer 9.00 Henk Blom Methylation in health and disease 9.20 Tom Teerlink ADMA & cardiovascular disease: villain, accomplice or innocent bystander? 9.40 Mirjam Wamelink New inherited defects of the pentose phosphate pathway: surprising phenotypes 10.00 Martijn Kranendijk D-2-hydroxyglutaric aciduria: novel insights 10.20 Eduard Struys Pyridoxine dependent epilepsy: accomplishments and remaining goals 10.40 Gajja Salomons Creatine deficiency syndromes: it is the brain that counts 11.00 – 11.30

coffee/tea

II. New disorders Chairman: Bwee Tien Poll-The/ John Walter 11.30 Marjo van der Knaap News from the white matter front 11.55 Jean Marie Saudubray Disorders of phospholipid and sphingolipid synthesis. A role for metabolomics? 12.20 Peter Clayton Whatever is the newest: Big surprise 12.45 Brian Fowler New disorders of cobalamine (B12) and folate metabolism 13.10 - 14.15

lunch

III. New pathways and mechanisms Chairman: Isabel Tavares de Almeida/ Johannes Zschocke 14.15 Ronald Wanders Pristanic-/Phytanic acid metabolism: how it started and where we are now 14.40 Emile van Schaftingen Faulty metabolite repair 15.05 Markus Ralser Pentose phosphate pathway: a metabolic redox sensor? 15.30 Larry Sweetman From prenatal diagnosis to neonatal screening: a moving scene 15.55 – 16.30

coffee/tea

IV. The Farewell Chairman: Rien Blankenstein 16.30 Mike Gibson 16.55 Cornelis Jakobs

Three Decades, Two Scientists and One Mouse: Clinical Trial(s) in SSADH Deficiency 40 years of IEM: a personal flashback

17.15 Rien Blankenstein

The “end” of an era

17.30 – 19.30

reception

List of speakers: prof. H Blom (VUmc, Amsterdam, the Netherlands) dr. M Kranendijk (VUmc, Amsterdam, the Netherlands) dr. G Salomons (VUmc, Amsterdam, the Netherlands) dr. E Struys (VUmc, Amsterdam, the Netherlands) dr. T Teerlink (VUmc, Amsterdam, the Netherlands) dr. M Wamelink (VUmc, Amsterdam, the Netherlands) prof. M Blankenstein (VUmc, Amsterdam, the Netherlands) prof. C Jakobs (VUmc, Amsterdam, the Netherlands) prof. M van der Knaap (VUmc, Amsterdam, the Netherlands) prof. R Wanders (AMC, Amsterdam, the Netherlands) prof. P Clayton (London, United Kingdom) prof. B Fowler (Basel, Switzerland) prof. M Gibson (Michigan, USA) dr. M Ralser (Berlin, Germany/Cambridge, United Kingdom) prof. JM Saudubray (Paris, France) prof. E van Schaftingen (Brussels, Belgium) dr. L Sweetman (Dallas, USA)

List of chairmen: dr. H ten Brink (VUmc, Amsterdam, the Netherlands) prof. M Blankenstein (VUmc, Amsterdam, the Netherlands) prof. BT Poll-The (AMC, Amsterdam, the Netherlands) dr. P Scheffer (VUmc, Amsterdam, the Netherlands) prof. I Tavares de Almeida (Lisbon, Portugal) dr. J Walter (Manchester, United Kingdom) prof. J Zschocke (Innsbruck, Austria)

Venues: Get-together



Symposium

to be announced Amstelzaal VU University Medical Center De Boelelaan 1117, 1081 HV, Amsterdam

Registration Admission is free. For logistical reasons, preregistration is highly appreciated before the 1st of November. Please mail your title, name, organisation and your participation of

1. the Get together on November 24th 2. the Symposium on November 25th (including lunch) 3. the Reception on November 25th

by e-mail to [email protected] tel + 31 (0)20 - 4442880 (Anneke Tekkelenburg, secretariat) Accreditation Accreditation has been requested at the Dutch Professional Organizations NVKC, NVK and NVHG. Public transport/parking Railways Amsterdam-Zuid. Tram: 5, 16, 24, 50 en 51. Further information can be found on the following websites http://ns.nl and http://www.gvb.nl Paid car parking See this website

Gustav Mahlerlaan. http://www.vumc.com/patientcare/477446/

Hotels Please see website http://www.iamsterdam.com/en/visiting/accommodation/looking-for-booking

Preliminary list of sponsors