EFFECTS OF THE HEXANE EXTRACT OF MONDIA WHITEI ON THE REPRODUCTIVE ORGANS OF MALE RAT

302 Afr. J. Trad. CAM (2005) 2 (3): 302 - 311 Research Paper Afr. J. Traditional, Complementary and Alternative Medicines www.africanethnomedicines...
Author: Roderick Cobb
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302

Afr. J. Trad. CAM (2005) 2 (3): 302 - 311

Research Paper

Afr. J. Traditional, Complementary and Alternative Medicines www.africanethnomedicines.net

ISSN 0189-6016©2005 EFFECTS OF THE HEXANE EXTRACT OF MONDIA WHITEI ON THE REPRODUCTIVE ORGANS OF MALE RAT. Pierre Watchoa*, Mireille M. Donfacka, Fabien Zelefackb, Telesphore B. Nguelefacka, Sylvie Wansia, Ferdinand Ngoulac, Pierre Kamtchouingc, Etienne Tsamob and Albert Kamanyia. a

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon, bDepartment of Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon, c Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon. E-mail: [email protected], Tel :+ 237 751 61 30, Fax: +237 345 21 82

Abstract The present study investigates the effects induced by the long term oral administration of the hexane extract of the dried roots of Mondia whitei at doses of 500 and 1000 mg/kg b.w. on body and organ weights, biochemical (cholesterol, total proteins), haematological (WBC, RBC, haematocrit) and physiological (mechanical response of vas deferens to Norepinephrine) parameters of rats treated for 30 days. Results showed that Mondia whitei did not affect the body and testes weights of rats. At high dose (1000 mg/kg b.w), there was a significant (p

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