Effects of Antimalaria Drugs on Antioxidant Status of Malaria Patients

International Journal of Pharmacy and Medical Sciences 6 (1): 20-29, 2016 ISSN 2222-5854 © IDOSI Publications, 2016 DOI: 10.5829/idosi.ijpms.2016.6.1....
Author: Verity Thornton
4 downloads 1 Views 415KB Size
International Journal of Pharmacy and Medical Sciences 6 (1): 20-29, 2016 ISSN 2222-5854 © IDOSI Publications, 2016 DOI: 10.5829/idosi.ijpms.2016.6.1.1121

Effects of Antimalaria Drugs on Antioxidant Status of Malaria Patients E.C. Onyeneke, 1A.O. Okuda, 1O.R. Akinyele, 1P.U. Onumaegbu, 1 Omokaro Eve Ukinebo, 2J. Anionye Chukudi and 2S.E. Oghagbon 1

Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Edo state, Nigeria 2 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, University of Benin, Benin City, Edo state, Nigeria 1

Abstract: Malaria infection has been found to be associated with lipid peroxidation accompanying reduction in antioxidant capacity of the infected patients especially Plasmodium falciparum infection. Antimalarial drugs also affects the oxidative stress pattern of malaria patients. The effects of malaria infection and the antimalaria drugs, chloroquine, sulfadoxine-pyremethamine and artemisinin combination therapy of the oxidant (malondialdehyde, MDA) and antioxidant status (enzyme and non-enzyme) of malaria patients were investigated. The result showed that the level of MDA was significantly elevated (p

Suggest Documents