Effect of Vitamin D Replacement on Atrial Electromechanical Delay in Subjects With Vitamin D Deficiency
Running Title: AEMD and Vitamin D Deficiency
Uğur CANPOLAT, MD (1) Çağrı YAYLA, MD (1) Mehmet Kadri AKBOĞA, MD (1) Elif Hande ÖZCAN, MD (1) Osman TURAK, MD, Associate Professor (1) Fırat ÖZCAN, MD, Associate Professor (1) Serkan TOPALOĞLU, MD, Professor (1) Dursun ARAS, MD, Professor (1) (1) Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey Corresponding author: Uğur Canpolat, MD. Türkiye Yüksek Ġhtisas Training and Research Hospital, Cardiology Clinic, Sıhhiye, 06100, Ankara, Turkey. Tel: +90 542 843 07 71. Fax: +90 312 306 1134 E-mail:
[email protected]
Disclosures: None
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jce.12656. This article is protected by copyright. All rights reserved.
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Abstract Objectives: Limited data are available regarding cardiac arrhythmias in vitamin D (VitD) deficiency. Therefore, we aimed to assess whether atrial electromechanical delay (AEMD) measured by tissue Doppler imaging (TDI), which is an indicator for atrial fibrillation (AF) development, is prolonged in patients with VitD deficiency as compared to control group. The effect of vitD replacement on AEMD was also evaluated. Methods: In this prospective study a total of 28 VitD deficient and 56 age-, gender- and BMI-matched VitD sufficient healthy participants were enrolled. P-wave dispersion (PWd) was calculated on the 12-lead electrocardiogram. Both intra- and inter-AEMD were calculated by TDI. Measurements were performed at baseline in both groups and were repeated after 6-month replacement therapy in subjects with vitD deficiency. Results: PWd, inter- and left intra-AEMD were significantly prolonged in patients with VitD deficiency compared to control group (p
