ebiobank Implementation of a Web-based Sample Information and Tracking System for Patient-based Biobanks
eBiobank
Implementation of a Web-based Sample Information and Tracking System for Patient-based Biobanks Dr. Turid Eide, Oslo University Hospital, NO...
Implementation of a Web-based Sample Information and Tracking System for Patient-based Biobanks Dr. Turid Eide, Oslo University Hospital, NORWAY
What is a biobank?
A biobank consists of collection, storage, treatment and destruction of human biological material Human biological material consists of organs, parts of organs, cells and tissues and components of this kind of material from living and dead . human beings
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Research biobank •A collection of human biological material which is or will be used for research purposes •Requires an explicit and specified informed consent •The consent must be documented and the patient can annul the consent •The request to establish a new research biobank must be approved by hospital regulations and the regional ethical committee
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The advantages of doing biobanking in Norway 4.9 million inhabitants Public educational and welfare system All individuals have a unique 11-digit ID-number A number of national health registries Possibilities to link biobanks to the registries Human biomedical research is mainly publicly funded
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Background of the project
The hospitals in the South-Eastern Norway Regional Health Authority generate 61% of all medical research in Norway
Clinical and translational medical research depends on the exploration of human biological material stored in biobanks, which are mainly located within the public hospital system
Attempts to utilize hospital biobanks for research purposes are time-consuming and sometimes impossible due to inadequate infrastructure: No institutional overview of human biological materialet (trackingsystem) No easy accessible documentation regarding the samples No institutional tools for handling of databases-/registries No overviews of already conducted research and analysis of the material No guidelines for research on already collected material No reuse of competence
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The eBiobank project Ahus
OUS
UUS
Aker
v i k
Radiumhospitalet
Rikshospitalet
eBiobank Goal: Create research friendly IT infrastructure –Tracking system for biological material
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The project members- Oslo University Hospital 70 different localizations 1.2 mill. pasient treatments 20 000 employees Largest hospital in North of Europe Total budget 17.5 billions 85 % of all research in HSØ 51% of all research in Norway Biobanks in more than 50% of all research projects
OUS
UUS
Aker
v i k
Radiumhospitalet
Rikshospitalet
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The project members- Ahus University Hospital
Surving population of 460 000 6400 employees One location Total budget of 6.4 billions
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More than 1400 Research Biobanks together
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Biobank Norway –WP3 Work package 3: •Coordinated by Oslo University Hospital on behalf of South-Eastern Norway Regional Health Authority •Provide tracking solutions for clinical biobanks in all the health regions •Implement a national overview of biobanks based upon ”minimum dataset”
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Criteria for a biobank tracking system: •Create user with appropriate role and access to the solution •Register biobank and necessary formalities •Identify donor and collect sample •Register and label sample •Process, aliquot and analyze sample (quality parameters) •Storing and withdrawal of samples •Keep track of informed consent •Sending and recieving of samples •Change access to sample, including destruction •Be 100% web-based
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Scalability The system should be dimensioned for the following approximate volumes: •500-1.200 sample collections •10-1.000.000 donors •10.000.000 samples •50-250 concurrent users
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Visual workflow
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Storage location‐the naked truth!!!
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Storage location
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Storage location
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Biobank Norway –WP3 Work package 3: •Coordinated by Oslo University Hospital on behalf of South-Eastern Norway Regional Health Authority •Provide tracking solutions for clinical biobanks •Implement a national overview of biobanks based upon ”minimum dataset”
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Minimum dataset ‐ Biobanks
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Minimum dataset
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Minimum dataset – implemented in the system
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“Specific” Research biobank containing one project
Specific research biobank
Material collected based upon specific consent
Projectleader responsible for establishing biobank
Project
Approval from the regional ethical committee
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“General” Research biobank containing several projects
Theme-based research biobank Department-wise Broad consent Establishment of consent-registry Approval by the PI/council for the biobank
Project 1 Specific consent
Project 2 Specific consent
Project 3 Specific consent
Approval from the regional ethical committee
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One biobank‐several research project
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Research Project
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Profits using a tracking system for biobanks •
Easier and better administration of regulatory requirements with easier documentation of sample administration and storage conditions
• • • • •
• • •
All processes documented electronically Better overview of the usage of the individual samples Better opportunities for long term storage of samples and data Real possibilities for reuse of material and infrastructur within the necessary regulations Better organization of research on human biological material from several biobank collections
Lower treshold for starting research projects Lower costs due to increased reuse of infrastructure New possibilities for collaborations and research projects
