Dr. Natalia V Guevara The University of Texas Rio Grande Valley Department of Physics (956) 882- 6752 Email: [email protected]

EDUCATION PhD, Moscow State University, 1989 Major: Biophysics Dissertation Title: Structural heterogeneity of low density lipoprotein(LDL), physical & chemical properties of LDL subgractions. BS, Moscow State University, 1985 Major: Physics Dissertation Title: Effect of pH on structure of low density lipoprotein from human plasma.

EMPLOYMENT Associate Professor , Department of Physics and Astronomy, UTB/TSC (2005 - Present) Assistant Professor , Department of Physics and Astronomy, UTB/TSC (September 2000 - August 2004) Lecturer, Physical Sciences Department, UTB/TSC (September 1998 - August 2000) Post-doctoral Associate, Dept. of Cell Biology, Baylor College of Medicine (April 1, 1995 - April 30, 1998) Visiting Research Associate, Dept. of Medicine, Baylor College of Medicine, Division of Arteriosclerosis and Lipoprotein (1992 - 1995) Research Associate,, National Cardiology Research Center, Moscow, Russia (1987 - 1992)

PUBLICATIONS Refereed Journals Articles Juan Guevara, Nagindra Prashad, Boris Ermolinsky, John Gaubatz, Dongcheul Kang, Andrea Schwarzbach, David Loose, and Natalia Guevara. "Apo B100 Similarities to Viral Proteins Suggest Basis for LDL-DNA Binding and Transfection Capacity." No. Journal of Lipid Research 51(7), (2010): 1704-1718.

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Natalia Guevara, Chen K-H, and Chan L.. "Apoptosis in atherosclerosis: pathological and pharmacological implications." No. Pharmacological Research 44:, (2001): 59-71. R. Collins, R. Velji, Natalia Guevara, L. Chan, and A Beaudet. "P-selectin or ICAM-1 deficiency protects against atherosclerosis in apo E-deficient mice.." No. The Journal of Experimental Medicine 191, (2000): 189-194. Natalia Guevara, D. Spencer, and L. Chan. "Apoptosis in atherosclerosis: role and regulation ." No. ). Current Opinion in Cardiovascular, Pulmonary, and Renal Investigational Drugs 1, (1999): 206-213. Natalia Guevara, H. Kim, E. Antonova, and L. Chan. "The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo." No. Nature Medicine 5, (1999): 335-339. C Yang, Z Gu, Y Xie, Natalia Guevara, M Yang, D Yeshurun, JAV Quion, and A Gotto. "Effect of gemfibrozil on very-low-density lipoprotein composition and low-density lipoprotein size in patients with hypertriglyceridemia or combined hyperlipidemia." no. Atherosclerosis 126, (1996): 105-126. A Maliugin, D Novikov, V Kosykh, E Kosenkov, N Medvedeva, and Natalia Guevara. "Inhibition of cholesterol biosynthesis in rabbit hepatocytes by 3-beta-(omega-hydroxyalkoxy)cholest-5-enes. (Russ.)." No. Bioorganicheskaya Khimiia (Bio-organic chemistry) 22, (1996): 541-547. Natalia Guevara, J Guevara, O Garcia, C Yang, S Legal, A Gotto, and J Sparrow. "Interactions of apolipoprotein[a] with apolipoproteinB-100 Cys3734 region in lipoprotein[a] is confirmed immunochemically.." No. J. Protein Chem 15, (1996): 17-25. J. Shen, E. Herderick, J Cornhill, E. Zsigmond, H. Kim, H Kuhn, Natalia Guevara, and L. Chan. "Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development." No. J. Clin. Invest 98, (1996): 2201-2208. Natalia Guevara, J Guevara, T Walsh, H Epstein, A Gotto, and J Sparrow. "Evidence that apoB-100 of low-density lipoproteins is a novel src-related protein kinase." No. J. Protein Chem 14:, (1995): 627-631. J Guevara, Natalia Guevara, C Yang, D Davison, and J Morrisett. "Regions in sequences of apolipoproteins similar to domains in signal transduction proteins." No. J. Endocrine Practice 1, (1995): 440-448. C Yang, Z Gu, Y Xie, Natalia Guevara, M Yang, D Yeshurun, J Qulon, and A Gotto. "Effects of Lopid-SR on plasma lipids and lipoproteins in patients with hypertriglyceridemia and combined hyperlipidemia.." No. Clinical Research 42, (1994): A160-A160. C Yang, Natalia Guevara, M Yang, Z Gu, and A Gotto. "Immunological approach to study the structure of oxidized low-density lipoprotein (Methods in Protein Structure Analysis short communication and abstracts)." No. J. Protein Chem 13, (1994): 469-470. Natalia Guevara, Z Gu, I Antonov, J Guyton, C Smith, A Gotto, and C Yang. "Immunoreactivity of apolipoprotein B-100 in oxidatively modified low density lipoprotein." No. Biological Chemistry Hoppe-Seyler 375, (1994): 651-658. J Guevara, J Sparrow, Natalia Guevara, D Davison, and J Morrisett. "Src Signal Sequences in Apoprotein B-100: Does LDL or Lp[a] Play a Role in Signal Transduction? Proc. Second Multiple Risk Factors Symp." No. . Multiple Risk Factors in Cardiovascular Disease (1994) C Yang, Z Gu, Natalia Guevara, H Pownall, B Lee, M Yang, Y Xie, J Guyton, T Vlasik, J Fruchart, and A Gotto. "Human Very Low Density Lipoprotein Structure: Interaction of the C Apolipoproteins with Apolipoprotein B-100." No. J. Lipid Res 34, (1993): 1311-1321. Generated on Jan 20, 2017

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Natalia Guevara, J Guevara, J Sparrow, C Yang, Y Xie, T Vlasik, and J Morrisett. "Localization of Apo-B-100 epitope interacting with apo [a] in human lipoprotein [a]. ." No. Circulation 88, (1993): 271-271. A Morozkin, N Medvedeva, and Natalia Guevara. " Analysis of the distribution of low density lipoprotein flotation coefficient using an analytical centrifuge equipped with absorption optics." No. Biofizika (Russ) 34:, (1989): 958-964. Natalia Guevara, T Bushueva, N Medvedeva, A Morozkin, and I Fuki. "Physico-chemical properties of low density lipoprotein subfractions isolated in an equilibrium density gradient." No. Molekularnaya Biologia (Russ.) (Molecular Biology) 23, (1989): 1154-1161. Natalia Guevara, N Medvedeva, A Morozkin, N Gorchakova, and E Ruuge. "Relative location of stearic acid anthroyl derivatives in low density lipoproteins." No. Biofizica (Russ.) (Bio-physics) 35, (1989): 1065-1066. A Morozkin, N Medvedeva, and Natalia Guevara. "Study of low density lipoprotein polydispersity on a low concentration scale." No. Studia biophysica 129:, (1989): 27-36. Journal Articles Natalia Guevara and J Guevara. P53 and its effectors in atherogenesis (review, invited). . No. BiotechLab International. 1, (2000): 10-12. N Medvedeva, A Morozkin, Natalia Guevara, I Scherbakova, I Gorshkova, A Lyakishev, and E Ruuge. density lipoprotein flotation mass-spectra, particle surface potential and plasma lipid composition in some dislipoproteinemias. No. Cardiovascular World Reports. 4, (1991): 102-108.

CONTRACTS, GRANTS AND SPONSORED RESEARCH Grants Natalia Guevara, "Mechanisms for cell uptake of LDL/DNA complexes. ," $263,279.00. (January 2012 - November 2014) Natalia Guevara, "Nucleic acid-binding properties of human low density lipoprotein, ," $241,000.00. (August 2007 - July 2010) Natalia Guevara, "Instrumentation proposal for acquiring Agilent Technologies Bioanalyzer 2100, and NanoDrop ND-3300 fluorospectrometer," $40,000.00. (August 2007 - July 2008) Natalia Guevara, "Studies of single biomolecules: DNA conformational dynamics and protein binding," $157,000.00. (August 2006 - February 2008) Natalia Guevara, "Characterization of DNA-binding properties of human low density lipoprotein.," $12,500.00. (March 2007 - October 2007) Natalia Guevara, "Acquisition of a Scanning Probe Microscope for Imaging and Force Spectroscopy of Single Biomolecules," $257,000.00. (August 2004 - July 2007) Natalia Guevara, "Studies of single biomolecules: DNA conformational dynamics and protein binding ," $200,000.00. (August 2005 - August 2006) Natalia Guevara, "Incorporation of laser optics and scanning probe microscopy into advanced undergraduate laboratories," $104,407.00. (August 2004 - August 2005) Natalia Guevara, "The use of Fluorescent-labeling compounds in demonstrating gene delivery and cytoplasmic translocation ," $226,160.00. (July 1999 - June 2000) Generated on Jan 20, 2017

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cytoplasmic translocation ," $226,160.00. (July 1999 - June 2000)

PRESENTATIONS Natalia Guevara and Juan Guevara. "Low Density Lipoproteins bind DNA and transfect cells – role of Apo B100." VIII International Conference "Fundamental Problems of Biophysics", , Physics Department/ Biophysics Division, Moscow State University, Moscow, Russia. . (November 2009) Natalia Guevara, A Merched, S Kim, E Antonova, and L Chan. "New insights into the role of p53 in atherosclerosis.." International Colloquium on Candidates Susceptibility Genes for Cardiovascular Diseases and Therapeutic Consequences, Nancy, France. (March 1999) E Yanushevskaya, T Vlasik, and Natalia Guevara. "Monoclonal Antibodies as a Specific Tool for Studying Apo B Conformation.." Abstracts from 62nd EAS Congress,, Jerusalem, Israel. (1993) J Guevara, Natalia Guevara, J Sparrow, C Yang, Y Xie, T Vlasik, and J Morrisett. "Localization of ApoB-100 Epitope Interacting with Apo[a] in Human Lipoprotein[a].." Abstracts From the AHA 66th Scientific Sessions, Atlanta, Georgia. Suppl. to Circulation. (1993) Natalia Guevara, I. Antonov, M. Yang, J. Guyton, A. Gotto, and C. Yang. "Effects of oxidatively modified low density lipoprotein on the reactivity of apolipoprotein B monoclonal antibodies. ." Abstracts from the ASBMB/DBC-ACS Joint Meeting, San-Diego, California, . (1993) E Yanushevskaya, Natalia Guevara, N. Medvedeva, T. Vlasik, and I. Trakht. "Human LDL heterogeneity tested by physico-chemical and immunochemical methods.." Poster sessions book of 9th International Symposium on Atherosclerosis, Rosemont-Chicago, USA, . (1991) N. Medvedeva, A. Morozkin, I. Gorshkova, T. Bushueva, T. Fuki, I. Scherbakova, Natalia Guevara, and E. Ruuge. "The relationship between physico-chemical properties and functional characteristics of low density lipoproteins in subjects without CHD and in CHD patients.." Poster sessions book of 8th International Symposium on atherosclerosis, Roma. (1988)

TEACHING Courses Taught Analysis of Biomolecules by Physical Methods Bioengineering Lab College Physics I General Physics I General Physics II Graduate Research in Physics Intro to Biophysics Math Methods I Math Methods in Physics I Mathematics for Scientists and Engineers I Phys of Biological Systems Physical Sciences for Educators I Generated on Jan 20, 2017

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Physical Sciences for Educators I Physics of Biological Systems Thermodynamics Thesis I UG Research University Physics I

SERVICE Department Service Committee Member, Personnel Committee, Curriculum Committee, Laboratory Instruction Committee, Department of Physics and Astronomy. (2010 - Present) Committee Chair, Personnel Committee of the Department of Physics and Astronomy.. (2008 2009) Committee Member, Personnel Committee of the Department of Biological Sciences . (2007 - 2009) Committee Chair, Department of Physics and Astronomy, . (2004 - 2008) Other, Department of Physics and Astronomy. (2003 - 2004) Committee Chair, Dept. of Physics &Astronomy Curriculum Committee. (2002 - 2003) Committee Member, curriculum committee, Department of Physical Sciences. (1998 - 2002)

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