Vol. 280, No. 30

The Journal of

July 29, 2005

Biological Chemistry This Issue Was Available in Electronic Form July 22, 2005 http://www.jbc.org Copyright © 2005 by the American Society for Biochemistry and Molecular Biology, Inc. 9650 Rockville Pike, Bethesda, MD 20814 U.S.A.

CONTENTS Arranged by Subject Categories CLASSICS □ C

MINIREVIEW 27477

27697

Cooperation between Small Nuclear RNA-activating Protein Complex (SNAPC) and TATA-box-binding Protein Antagonizes Protein Kinase CK2 Inhibition of DNA Binding by SNAPC. Liping Gu, Walter J. Esselman, and R. William Henry

27742

Novel Autoregulatory Function of Hepatitis B Virus M Protein on Surface Gene Expression. Tsurng-Juhn Huang, Cheng-Chan Lu, Jui-Chen Tsai, Wei-Jen Yao, Xuanyong Lu, Ming-Derg Lai, Hsiao-Sheng Liu, and Ai-Li Shiau

27783

FBI-1 Enhances Transcription of the Nuclear Factor-␬B (NF-␬B)-responsive E-selectin Gene by Nuclear Localization of the p65 Subunit of NF-␬B. Dong-Kee Lee, Jae-Eun Kang, Hye-Jin Park, Myung-Hwa Kim, Tae-Hee Yim, Jung-Min Kim, Min-Kyu Heo, Kyu-Yeun Kim, Ho Jeong Kwon, and Man-Wook Hur

28061

Transcriptional Activity of Sp1 Is Regulated by Molecular Interactions between the Zinc Finger DNA Binding Domain and the Inhibitory Domain with Corepressors, and This Interaction Is Modulated by MEK. Jung-Ahn Lee, Dong-Chul Suh, Jae-Eun Kang, Myung-Hwa Kim, Hyejin Park, Min-Nyung Lee, Jung-Min Kim, Bu-Nam Jeon, Hee-Eun Roh, Mi-Young Yu, Kang-Yell Choi, Kyu Yeun Kim, and Man-Wook Hur

28133

Induction of p53 by Urokinase in Lung Epithelial Cells. Sreerama Shetty, Margaret R. Gyetko, and Andrew P. Mazar

A Role for Phosphoinositides in Signaling: the Work of Mabel R. Hokin and Lowell E. Hokin (http://www.jbc.org/cgi/content/full/280/30/e27)

Allosteric Hemoglobin Assembly: Diversity and Similarity. William E. Royer, Jr., Hao Zhu, Thomas A. Gorr, Jason F. Flores, and James E. Knapp

DNA: REPLICATION, REPAIR, AND RECOMBINATION 27587

Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association. David B. Young, Jyoti Jonnalagadda, Magtouf Gatei, David A. Jans, Stephen Meyn, and Kum Kum Khanna

27624

Acute Reduction of an Origin Recognition Complex (ORC) Subunit in Human Cells Reveals a Requirement of ORC for Cdk2 Activation. Yuichi J. Machida, Jamie K. Teer, and Anindya Dutta

28072

Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1. Sudha Sharma, Joshua A. Sommers, Saba Choudhary, Jinnifer Korin Faulkner, Sheng Cui, Lucia Andreoli, Laura Muzzolini, Alessandro Vindigni, and Robert M. Brosh, Jr.

□ S

28085

□ S

RNA: STRUCTURE, METABOLISM, AND CATALYSIS

RECQ1 Helicase Interacts with Human Mismatch Repair Factors That Regulate Genetic Recombination. Kevin M. Doherty, Sudha Sharma, Laura A. Uzdilla, Teresa M. Wilson, Sheng Cui, Alessandro Vindigni, and Robert M. Brosh, Jr.

27595

GENES: STRUCTURE AND REGULATION 27523

27544

27552

□ S

Efficient Processing of Primary Micro-RNA Hairpins by Drosha Requires Flanking Nonstructured RNA Sequences. Yan Zeng and Bryan R. Cullen

PROTEIN SYNTHESIS, POST-TRANSLATION MODIFICATION, AND DEGRADATION

High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding. Yuho Najima, Naoya Yahagi, Yoshinori Takeuchi, Takashi Matsuzaka, Motohiro Sekiya, Yoshimi Nakagawa, Michiyo Amemiya-Kudo, Hiroaki Okazaki, Sachiko Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Kenji Harada, Takanari Gotoda, Ryozo Nagai, Takashi Kadowaki, Shun Ishibashi, Nobuhiro Yamada, Jun-ichi Osuga, and Hitoshi Shimano Inhibition of Platelet-derived Growth Factor-induced Cell Growth Signaling by a Short Interfering RNA for EWS-Fli1 via Down-regulation of Phospholipase D2 in Ewing Sarcoma Cells. Satoshi Nozawa, Takatoshi Ohno, Yoshiko Banno, Taikoh Dohjima, Kazuhiko Wakahara, De-Gang Fan, and Katsuji Shimizu Differentiation-dependent Alterations in Histone Methylation and Chromatin Architecture at the Inducible Chicken Lysozyme Gene. Pascal Lefevre, Claire Lacroix, Hiromi Tagoh, Maarten Hoogenkamp, Svitlana Melnik, Richard Ingram, and Constanze Bonifer

27481

Yeast as a Tractable Genetic System for Functional Studies of the Insulin-degrading Enzyme. Seonil Kim, Andrea N. Lapham, Christopher G. K. Freedman, Tiffany L. Reed, and Walter K. Schmidt

27670

Effective Translation of the Second Cistron in Two Drosophila Dicistronic Transcripts Is Determined by the Absence of In-frame AUG Codons in the First Cistron. Adam A. Wall, A. Marie Phillips, and Leonard E. Kelly

27866

Cell Surface Expression of CD147/EMMPRIN Is Regulated by Cyclophilin 60. Tatiana Pushkarsky, Vyacheslav Yurchenko, Christophe Vanpouille, Beda Brichacek, Iosif Vaisman, Shigetsugu Hatakeyama, Keiichi I. Nakayama, Barbara Sherry, and Michael I. Bukrinsky

28127

Role of p97 AAA-ATPase in the Retrotranslocation of the Cholera Toxin A1 Chain, a Non-ubiquitinated Substrate. Michael Kothe, Yihong Ye, Jessica S. Wagner, Heidi E. De Luca, Eli Kern, Tom A. Rapoport, and Wayne I. Lencer

The cover shows the surface of one-half of PLP synthase, a vitamin B6 biosynthetic enzyme found in plants, fungi, and some eubacteria. Twelve PdxS subunits (two highlighted as ribbons) associate as a double hexameric ring with the active sites lining the inside surface of the cylindrical dodecamer. The intact enzyme also includes PdxT subunits, which deliver ammonia to the PdxS active sites. For details see the article by Zhu et al., pages 27914 –27923.

⽧ Paper of the Week.

Full Instructions to Authors will be found on the web at www.jbc.org.

□ C Available in the online journal only. □ S Online version of this article contains supplemental material. v

vi

GENOMICS, PROTEOMICS, AND BIOINFORMATICS 28007

PROTEIN STRUCTURE AND FOLDING 27688

□ S

27839

The Fucose-binding Lectin from Ralstonia solanacearum. A NEW TYPE OF ␤-PROPELLER ARCHITECTURE FORMED BY OLIGOMERIZATION AND INTERACTING WITH FUCOSIDE, FUCOSYLLACTOSE, AND PLANT XYLOGLUCAN. Nikola Kostla´nova´, Edward P. Mitchell, Hugues Lortat-Jacob, Stefan Oscarson, Martina Lahmann, Nechama Gilboa-Garber, Ge´rard Chambat, Michaela Wimmerova´, and Anne Imberty

27935

Peptides Derived from Human Decorin Leucine-rich Repeat 5 Inhibit Angiogenesis. Konerirajapuram N. Sulochana, Huapeng Fan, Seetharama Jois, Vivekanandan Subramanian, Feng Sun, R. Manjunatha Kini, and Ruowen Ge

27970

The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix. Kate E. Gregory, Robert N. Ono, Noe L. Charbonneau, Chiu-Liang Kuo, Douglas R. Keene, Hans Peter Ba¨chinger, and Lynn Y. Sakai

Cross-species Sequence Analysis Reveals Multiple Charged Residue-rich Domains That Regulate Nuclear/ Cytoplasmic Partitioning and Membrane Localization of A Kinase Anchoring Protein 12 (SSeCKS/Gravin). Jeffrey W. Streb and Joseph M. Miano

Characterization of the Intraflagellar Transport Complex B Core. DIRECT INTERACTION OF THE IFT81 AND IFT74/72 SUBUNITS. Ben F. Lucker, Robert H. Behal, Hongmin Qin, Laura C. Siron, W. David Taggart, Joel L. Rosenbaum, and Douglas G. Cole

27719

Characterization of Four Variant Forms of Human Propionyl-CoA Carboxylase Expressed in Escherichia coli. Hua Jiang, K. Sudhindra Rao, Vivien C. Yee, and Jan P. Kraus

27792

Staphylococcus aureus Aminopeptidase S Is a Founding Member of a New Peptidase Clan. Sergey G. Odintsov, Izabela Sabala, Gleb Bourenkov, Vladimir Rybin, and Matthias Bochtler

27533

H1 Family Histones in the Nucleus. CONTROL OF BINDING AND LOCALIZATION BY THE C-TERMINAL DOMAIN. John P. H. Th’ng, Rohyun Sung, Ming Ye, and Michael J. Hendzel

Thyroid Hormone Regulates the Hypotriglyceridemic Gene APOA5. Xavier Prieur, Thierry Huby, Herve´ Coste, Frank G. Schaap, M. John Chapman, and Joan C. Rodrı´guez

27578

Phosphate-limited Oat. THE PLASMA MEMBRANE AND THE TONOPLAST AS MAJOR TARGETS FOR PHOSPHOLIPID-TO-GLYCOLIPID REPLACEMENT AND STIMULATION OF PHOSPHOLIPASES IN THE PLASMA MEMBRANE. Mats X. Andersson, Karin E. Larsson, Henrik Tjellstro¨m, Conny Liljenberg, and Anna Stina Sandelius

28044

Secretory Phospholipases A2 Induce Neurite Outgrowth in PC12 Cells through Lysophosphatidylcholine Generation and Activation of G2A Receptor. Yutaka Ikeno, Naoko Konno, So-hyun Cheon, Angelo Bolchi, Simone Ottonello, Katsuhiko Kitamoto, and Manabu Arioka

28103

Caveolin-1 Is Not Required for Murine Intestinal Cholesterol Transport. Mark A. Valasek, Jian Weng, Philip W. Shaul, Richard G. W. Anderson, and Joyce J. Repa

27809

27832

27872

27904

Crystal Structure of Kunitz Domain 1 (KD1) of Tissue Factor Pathway Inhibitor-2 in Complex with Trypsin. IMPLICATIONS FOR KD1 SPECIFICITY OF INHIBITION. Amy E. Schmidt, Hitendra S. Chand, Dulio Cascio, Walter Kisiel, and S. Paul Bajaj Platelet-derived Growth Factor Receptor-␤ (PDGFR-␤) Activation Promotes Its Association with the Low Density Lipoprotein Receptor-related Protein (LRP). EVIDENCE FOR CO-RECEPTOR FUNCTION. Christopher S. Newton, Elena Loukinova, Irina Mikhailenko, Sripriya Ranganathan, Yamei Gao, Christian Haudenschild, and Dudley K. Strickland

LIPIDS AND LIPOPROTEINS

The 1.3 Å Crystal Structure of the Flavoprotein YqjM Reveals a Novel Class of Old Yellow Enzymes. Karina Kitzing, Teresa B. Fitzpatrick, Corinna Wilken, Justyna Sawa, Gleb P. Bourenkov, Peter Macheroux, and Tim Clausen

MEMBRANE TRANSPORT, STRUCTURE, FUNCTION, AND BIOGENESIS

27914

A New Arrangement of (␤/␣)8 Barrels in the Synthase Subunit of Pyridoxal 5ⴕ-Phosphate Synthase. Jianghai Zhu, John W. Burgner, Etti Harms, Boris R. Belitsky, and Janet L. Smith

27502

Chimeric Mutations in the M2 Segment of the 5-Hydroxytryptamine-gated Chloride Channel MOD-1 Define a Minimal Determinant of Anion/Cation Permeability. Claudine Menard, H. Robert Horvitz, and Stephen Cannon

28118

The Cotranslational Contacts between Ribosome-bound Nascent Polypeptides and the Subunits of the Heterooligomeric Chaperonin TRiC Probed by Photocross-linking. Stephanie A. Etchells, Anne S. Meyer, Alice Y. Yam, Anne Roobol, Yiwei Miao, Yuanlong Shao, Martin J. Carden, William R. Skach, Judith Frydman, and Arthur E. Johnson

27604

The Role of Galacturonic Acid in Outer Membrane Stability in Klebsiella pneumoniae. Emilisa Frirdich, Catrien Bouwman, Evgeny Vinogradov, and Chris Whitfield

27613

Cog1p Plays a Central Role in the Organization of the Yeast Conserved Oligomeric Golgi Complex. Pierre Fotso, Yulia Koryakina, Oleksandra Pavliv, Arnold B. Tsiomenko, and Vladimir V. Lupashin

ENZYME CATALYSIS AND REGULATION

27679

Loss of Outer Membrane Proteins without Inhibition of Lipid Export in an Escherichia coli YaeT Mutant. William T. Doerrler and Christian R. H. Raetz

27713

Intracellular Trafficking of Thyroid Peroxidase to the Cell Surface. Regina Kuliawat, Jose Ramos-Castan˜eda, Youfang Liu, and Peter Arvan

27776

Interaction of FXYD10 (PLMS) with Na,K-ATPase from Shark Rectal Glands. CLOSE PROXIMITY OF Cys74 OF FXYD10 TO Cys254 IN THE A DOMAIN OF THE ␣-SUBUNIT REVEALED BY INTERMOLECULAR THIOL CROSS-LINKING. Yasser Ahmed Mahmmoud, Henrik Vorum, and Flemming Cornelius

27896

Cysteine-mediated Cross-linking Indicates That Subunit C of the V-ATPase Is in Close Proximity to Subunits E and G of the V1 Domain and Subunit a of the V0 Domain. Takao Inoue and Michael Forgac

28015

Functional Analysis of Slac2-c/MyRIP as a Linker Protein between Melanosomes and Myosin VIIa. Taruho S. Kuroda and Mitsunori Fukuda

28053

RIC-3 Affects Properties and Quantity of Nicotinic Acetylcholine Receptors via a Mechanism That Does Not Require the Coiled-coil Domains. Hagit Cohen Ben-Ami, Lina Yassin, Hanna Farah, Avner Michaeli, Margalit Eshel, and Millet Treinin

28095

A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation. Stuart G. Dashper, Catherine A. Butler, J. Patricia Lissel, Rita A. Paolini, Brigitte Hoffmann, Paul D. Veith, Neil M. O’Brien-Simpson, Sarah L. Snelgrove, John T. Tsiros, and Eric C. Reynolds

⽧

27508

27990

Substrate Specificity and Recognition Is Conferred by the Pleckstrin Homology Domain of the Dbl Family Guanine Nucleotide Exchange Factor P-Rex2. Raji E. Joseph and F. A. Norris Structural Insights into the Mechanism of Nuclease A, a ␤␤␣ Metal Nuclease from Anabaena. Mahua Ghosh, Gregor Meiss, Alfred Pingoud, Robert E. London, and Lars C. Pedersen

□ S

METABOLISM AND BIOENERGETICS 27815

Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid. Alexander R. Moise, Vladimir Kuksa, William S. Blaner, Wolfgang Baehr, and Krzysztof Palczewski

27960

Quantitative Calcium Measurements in Subcellular Compartments of Plasmodium falciparum-infected Erythrocytes. Petra Rohrbach, Oliver Friedrich, Joachim Hentschel, Helmut Plattner, Rainer H. A. Fink, and Michael Lanzer

□ S

27981

Modulation of Charge in the Phosphate Binding Site of Escherichia coli ATP Synthase. Zulfiqar Ahmad and Alan E. Senior

GLYCOBIOLOGY AND EXTRACELLULAR MATRICES 27513

Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation. Hsu Chao and Andrew P. Spicer

□ S

vii 28110

□ S

27888

Inhibition of Activator Protein-1, NF-␬B, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid. Rentian Feng, Yongju Lu, Linda L. Bowman, Yong Qian, Vincent Castranova, and Min Ding

27924

Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell ReceptorAntigen Complexes at the Cell Surface. Linda Wooldridge, Hugo A. van den Berg, Meir Glick, Emma Gostick, Bruno Laugel, Sarah L. Hutchinson, Anita Milicic, Jason M. Brenchley, Daniel C. Douek, David A. Price, and Andrew K. Sewell

Uncoupling and Endocytosis of 5-Hydroxytryptamine 4 Receptors. DISTINCT MOLECULAR EVENTS WITH DIFFERENT GRK2 REQUIREMENTS. Gae¨l Barthet, Florence Gaven, Be´re´nice Framery, Katsuhiro Shinjo, Takaaki Nakamura, Sylvie Claeysen, Joe¨l Bockaert, and Aline Dumuis

28034

Phosphatidylinositol-4-phosphate 5-Kinase Regulates Fission Yeast Cell Integrity through a Phospholipase Cmediated Protein Kinase C-independent Pathway. Lu Deng, Reiko Sugiura, Kazuki Ohta, Kazuki Tada, Masahiro Suzuki, Masato Hirata, Shun-ichi Nakamura, Hisato Shuntoh, and Takayoshi Kuno

Contribution of the Carboxyl Terminus of the VPAC1 Receptor to Agonist-induced Receptor Phosphorylation, Internalization, and Recycling. Christelle Langlet, Ingrid Langer, Pascale Vertongen, Nathalie Gaspard, Jean-Marie Vanderwinden, and Patrick Robberecht

28142

Inhibition of Nuclear Import of LIMK2 in Endothelial Cells by Protein Kinase C-dependent Phosphorylation at Ser-283. Pankaj Goyal, Dharmendra Pandey, Antje Behring, and Wolfgang Siess

A Role for Mitogen-activated Protein KinaseErk1/2 Activation and Non-selective Pore Formation in P2X7 Receptor-mediated Thymocyte Death. Rodolphe Auger, Iris Motta, Karim Benihoud, David M. Ojcius, and Jean M. Kanellopoulos

28162

Genetic and Pharmacologic Evidence That Calcium-independent Phospholipase A2␤ Regulates Virus-induced Inducible Nitric-oxide Synthase Expression by Macrophages. Jason M. Moran, R. Mark L. Buller, Jane McHowat, John Turk, Mary Wohltmann, Richard W. Gross, and John A. Corbett

Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the ␤-Amyloid Precursor Protein and Amyloid ␤-Peptide. Irfan Y. Tamboli, Kai Prager, Esther Barth, Michael Heneka, Konrad Sandhoff, and Jochen Walter

MECHANISMS OF SIGNAL TRANSDUCTION 27491

□ S

27561

27569

□ S

27645

AIP4 Restricts Transforming Growth Factor-␤ Signaling through a Ubiquitination-independent Mechanism. Franc¸ois Lallemand, Su Ryeon Seo, Nathalie Ferrand, Marcia Pessah, Sebastien L’Hoste, Georges Rawadi, Sergio RomanRoman, Jacques Camonis, and Azeddine Atfi

27654

Molecular Definition of a Novel Inositol Polyphosphate Metabolic Pathway Initiated by Inositol 1,4,5-Trisphosphate 3-Kinase Activity in Saccharomyces cerevisiae. Andrew M. Seeds, Robert J. Bastidas, and John D. York

27662

␮ and ␬ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes. Mariana M. Belcheva, Amy L. Clark, Paul D. Haas, Jannie S. Serna, Jason W. Hahn, Alexi Kiss, and Carmine J. Coscia

27705

27728

□ S

GIT1 Is a Scaffold for ERK1/2 Activation in Focal Adhesions. Guoyong Yin, Qinlei Zheng, Chen Yan, and Bradford C. Berk Simultaneous Blockade of NF␬B, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes. Axel Thiefes, Sabine Wolter, J. Frederic Mushinski, Elke Hoffmann, Oliver Dittrich-Breiholz, Nadine Graue, Anneke Do¨rrie, Heike Schneider, Dagmar Wirth, Bruno Luckow, Klaus Resch, and Michael Kracht

27759

Pellino3 Is a Novel Upstream Regulator of p38 MAPK and Activates CREB in a p38-dependent Manner. Marion P. Butler, Jennifer A. Hanly, and Paul N. Moynagh

27800

Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor ␤1 with Higher Affinity Receptors and an Activated Alk1 Pathway. Nadia Pece-Barbara, Sonia Vera, Kirishanthy Kathirkamathamby, Stefan Liebner, Gianni M. Di Guglielmo, Elisabetta Dejana, Jeffrey L. Wrana, and Michelle Letarte

27826

27850

27879

□ S

□ S

Imaging Epidermal Growth Factor Receptor Phosphorylation in Human Colorectal Cancer Cells and Human Tissues. Michael Keese, Richard J. Magdeburg, Torsten Herzog, Till Hasenberg, Martin Offterdinger, Rainer Pepperkok, Jo¨rg W. Sturm, and Philippe I. H. Bastiaens Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit. S. Chandra Shekar, Haiyan Wu, Zheng Fu, Shu-Chin Yip, Nagajyothi, Sean M. Cahill, Mark E. Girvin, and Jonathan M. Backer Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-␣. Yosuke Osawa, Hiroshi Uchinami, Jacek Bielawski, Robert F. Schwabe, Yusuf A. Hannun, and David A. Brenner

MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY 27631

Molecular Dissection of PINCH-1 Reveals a Mechanism of Coupling and Uncoupling of Cell Shape Modulation and Survival. Zhen Xu, Tomohiko Fukuda, You Li, Xiliang Zha, Jun Qin, and Chuanyue Wu

27638

Regulation of the Expression of Caspase-9 by the Transcription Factor Activator Protein-4 in Glucocorticoidinduced Apoptosis. Kyoko Tsujimoto, Takeshi Ono, Masaki Sato, Takashi Nishida, Takemi Oguma, and Takushi Tadakuma

27755

Inhibition of Membrane Type-1 Matrix Metalloproteinase by Cancer Drugs Interferes with the Homing of Diabetogenic T Cells into the Pancreas. Alexei Y. Savinov, Dmitri V. Rozanov, Vladislav S. Golubkov, F. Susan Wong, and Alex Y. Strongin

27769

Structural Organization of a Sex-comb-on-midleg/Polyhomeotic Copolymer. Chongwoo A. Kim, Michael R. Sawaya, Duilio Cascio, Woojae Kim, and James U. Bowie

27856

A Causative Role of Stromelysin-3 in Extracellular Matrix Remodeling and Epithelial Apoptosis during Intestinal Metamorphosis in Xenopus laevis. Liezhen Fu, Atsuko Ishizuya-Oka, Daniel R. Buchholz, Tosikazu Amano, Hiroki Matsuda, and Yun-Bo Shi

27949

Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway. INDUCTION OF A PERFORIN-LIKE MOLECULE. Matthias Wiens, Michael Korzhev, Anatoli Krasko, Narsinh L. Thakur, Sanja Perovic´-Ottstadt, Hans J. Breter, Hiroshi Ushijima, Ba¨rbel Diehl-Seifert, Isabel M. Mu¨ller, and Werner E. G. Mu¨ller

27998

Human Aldehyde Dehydrogenase 3A1 Inhibits Proliferation and Promotes Survival of Human Corneal Epithelial Cells. Aglaia Pappa, Donald Brown, Yiannis Koutalos, James DeGregori, Carl White, and Vasilis Vasiliou

28023

Differential Activities and Regulation of Saccharomyces cerevisiae Formin Proteins Bni1 and Bnr1 by Bud6. James B. Moseley and Bruce L. Goode

28152

CTCF Regulates Growth and Erythroid Differentiation of Human Myeloid Leukemia Cells. Vero´nica Torrano, Igor Chernukhin, France Docquier, Vivien D’Arcy, Javier Leo´n, Elena Klenova, and M. Dolores Delgado

□ S

ix

AUTHOR INDEX Ahmad, Zulfiqar, 27981 Amano, Tosikazu, 27856 Amemiya-Kudo, Michiyo, 27523 Anderson, Richard G. W., 28103 Andersson, Mats X., 27578 Andreoli, Lucia, 28072 Arioka, Manabu, 28044 Arvan, Peter, 27713 Atfi, Azeddine, 27645 Auger, Rodolphe, 28142

Docquier, France, 28152 Doerrler, William T., 27679 Doherty, Kevin M., 28085 Dohjima, Taikoh, 27544 Do¨rrie, Anneke, 27728 Douek, Daniel C., 27491 Dumuis, Aline, 27924 Dutta, Anindya, 27624

Ba¨chinger, Hans Peter, 27970 Backer, Jonathan M., 27850 Baehr, Wolfgang, 27815 Bajaj, S. Paul, 27832 Banno, Yoshiko, 27544 Barth, Esther, 28110 Barthet, Gae¨l, 27924 Bastiaens, Philippe I. H., 27826 Bastidas, Robert J., 27654 Behal, Robert H., 27688 Behring, Antje, 27569 Belcheva, Mariana M., 27662 Belitsky, Boris R., 27914 Benihoud, Karim, 28142 Berk, Bradford C., 27705 Bielawski, Jacek, 27879 Blaner, William S., 27815 Bochtler, Matthias, 27792 Bockaert, Joe¨l, 27924 Bolchi, Angelo, 28044 Bonifer, Constanze, 27552 Bourenkov, Gleb, 27792 Bourenkov, Gleb P., 27904 Bouwman, Catrien, 27604 Bowie, James U., 27769 Bowman, Linda L., 27888 Brenchley, Jason M., 27491 Brenner, David A., 27879 Breter, Hans J., 27949 Brichacek, Beda, 27866 Brosh, Robert M., Jr., 28072, 28085 Brown, Donald, 27998 Buchholz, Daniel R., 27856 Bukrinsky, Michael I., 27866 Buller, R. Mark L., 28162 Burgner, John W., 27914 Butler, Catherine A., 28095 Butler, Marion P., 27759

Fan, De-Gang, 27544 Fan, Huapeng, 27935 Farah, Hanna, 28053 Faulkner, Jinnifer Korin, 28072 Feng, Rentian, 27888 Ferrand, Nathalie, 27645 Fink, Rainer H. A., 27960 Fitzpatrick, Teresa B., 27904 Flores, Jason F., 27477 Forgac, Michael, 27896 Fotso, Pierre, 27613 Framery, Be´re´nice, 27924 Freedman, Christopher G. K., 27481 Friedrich, Oliver, 27960 Frirdich, Emilisa, 27604 Frydman, Judith, 28118 Fu, Liezhen, 27856 Fu, Zheng, 27850 Fukuda, Mitsunori, 28015 Fukuda, Tomohiko, 27631

Cahill, Sean M., 27850 Camonis, Jacques, 27645 Cannon, Stephen, 27502 Carden, Martin J., 28118 Cascio, Duilio, 27769 Cascio, Dulio, 27832 Castranova, Vincent, 27888 Chambat, Ge´rard, 27839 Chand, Hitendra S., 27832 Chao, Hsu, 27513 Chapman, M. John, 27533 Charbonneau, Noe L., 27970 Cheon, So-hyun, 28044 Chernukhin, Igor, 28152 Choi, Kang-Yell, 28061 Choudhary, Saba, 28072 Claeysen, Sylvie, 27924 Clark, Amy L., 27662 Clausen, Tim, 27904 Cohen Ben-Ami, Hagit, 28053 Cole, Douglas G., 27688 Corbett, John A., 28162 Cornelius, Flemming, 27776 Coscia, Carmine J., 27662 Coste, Herve´, 27533 Cui, Sheng, 28072, 28085 Cullen, Bryan R., 27595 D’Arcy, Vivien, 28152 Dashper, Stuart G., 28095 DeGregori, James, 27998 Dejana, Elisabetta, 27800 Delgado, M. Dolores, 28152 De Luca, Heidi E., 28127 Deng, Lu, 27561 Diehl-Seifert, Ba¨rbel, 27949 Di Guglielmo, Gianni M., 27800 Ding, Min, 27888 Dittrich-Breiholz, Oliver, 27728

Eshel, Margalit, 28053 Esselman, Walter J., 27697 Etchells, Stephanie A., 28118

Gao, Yamei, 27872 Gaspard, Nathalie, 28034 Gatei, Magtouf, 27587 Gaven, Florence, 27924 Ge, Ruowen, 27935 Ghosh, Mahua, 27990 Gilboa-Garber, Nechama, 27839 Girvin, Mark E., 27850 Glick, Meir, 27491 Golubkov, Vladislav S., 27755 Goode, Bruce L., 28023 Gorr, Thomas A., 27477 Gostick, Emma, 27491 Gotoda, Takanari, 27523 Goyal, Pankaj, 27569 Graue, Nadine, 27728 Gregory, Kate E., 27970 Gross, Richard W., 28162 Gu, Liping, 27697 Gyetko, Margaret R., 28133 Haas, Paul D., 27662 Hahn, Jason W., 27662 Hanly, Jennifer A., 27759 Hannun, Yusuf A., 27879 Harada, Kenji, 27523 Harms, Etti, 27914 Hasenberg, Till, 27826 Hatakeyama, Shigetsugu, 27866 Haudenschild, Christian, 27872 Hendzel, Michael J., 27809 Heneka, Michael, 28110 Henry, R. William, 27697 Hentschel, Joachim, 27960 Heo, Min-Kyu, 27783 Herzog, Torsten, 27826 Hirata, Masato, 27561 Hoffmann, Brigitte, 28095 Hoffmann, Elke, 27728 Hoogenkamp, Maarten, 27552 Horvitz, H. Robert, 27502 Huang, Tsurng-Juhn, 27742 Huby, Thierry, 27533 Hur, Man-Wook, 27783, 28061 Hutchinson, Sarah L., 27491 Iizuka, Yoko, 27523 Ikeno, Yutaka, 28044 Imberty, Anne, 27839 Ingram, Richard, 27552 Inoue, Takao, 27896 Ishibashi, Shun, 27523 Ishizuya-Oka, Atsuko, 27856 Jans, David A., 27587 Jeon, Bu-Nam, 28061

Jiang, Hua, 27719 Johnson, Arthur E., 28118 Jois, Seetharama, 27935 Jonnalagadda, Jyoti, 27587 Joseph, Raji E., 27508 Kadowaki, Takashi, 27523 Kanellopoulos, Jean M., 28142 Kang, Jae-Eun, 27783, 28061 Kathirkamathamby, Kirishanthy, 27800 Keene, Douglas R., 27970 Keese, Michael, 27826 Kelly, Leonard E., 27670 Kern, Eli, 28127 Khanna, Kum Kum, 27587 Kim, Chongwoo A., 27769 Kim, Jung-Min, 27783, 28061 Kim, Kyu-Yeun, 27783 Kim, Kyu Yeun, 28061 Kim, Myung-Hwa, 27783, 28061 Kim, Seonil, 27481 Kim, Woojae, 27769 Kini, R. Manjunatha, 27935 Kisiel, Walter, 27832 Kiss, Alexi, 27662 Kitamoto, Katsuhiko, 28044 Kitzing, Karina, 27904 Klenova, Elena, 28152 Knapp, James E., 27477 Konno, Naoko, 28044 Koryakina, Yulia, 27613 Korzhev, Michael, 27949 Kostla´nova´, Nikola, 27839 Kothe, Michael, 28127 Koutalos, Yiannis, 27998 Kracht, Michael, 27728 Krasko, Anatoli, 27949 Kraus, Jan P., 27719 Kuksa, Vladimir, 27815 Kuliawat, Regina, 27713 Kuno, Takayoshi, 27561 Kuo, Chiu-Liang, 27970 Kuroda, Taruho S., 28015 Kwon, Ho Jeong, 27783 Lacroix, Claire, 27552 Lahmann, Martina, 27839 Lai, Ming-Derg, 27742 Lallemand, Franc¸ois, 27645 Langer, Ingrid, 28034 Langlet, Christelle, 28034 Lanzer, Michael, 27960 Lapham, Andrea N., 27481 Larsson, Karin E., 27578 Laugel, Bruno, 27491 Lee, Dong-Kee, 27783 Lee, Jung-Ahn, 28061 Lee, Min-Nyung, 28061 Lefevre, Pascal, 27552 Lencer, Wayne I., 28127 Leo´n, Javier, 28152 Letarte, Michelle, 27800 L’Hoste, Sebastien, 27645 Li, You, 27631 Liebner, Stefan, 27800 Liljenberg, Conny, 27578 Lissel, J. Patricia, 28095 Liu, Hsiao-Sheng, 27742 Liu, Youfang, 27713 London, Robert E., 27990 Lortat-Jacob, Hugues, 27839 Loukinova, Elena, 27872 Lu, Cheng-Chan, 27742 Lu, Xuanyong, 27742 Lu, Yongju, 27888 Lucker, Ben F., 27688 Luckow, Bruno, 27728 Lupashin, Vladimir V., 27613 Macheroux, Peter, 27904 Machida, Yuichi J., 27624 Magdeburg, Richard J., 27826 Mahmmoud, Yasser Ahmed, 27776 Matsuda, Hiroki, 27856 Matsuzaka, Takashi, 27523 Mazar, Andrew P., 28133 McHowat, Jane, 28162 Meiss, Gregor, 27990 Melnik, Svitlana, 27552

Menard, Claudine, 27502 Meyer, Anne S., 28118 Meyn, Stephen, 27587 Miano, Joseph M., 28007 Miao, Yiwei, 28118 Michaeli, Avner, 28053 Mikhailenko, Irina, 27872 Milicic, Anita, 27491 Mitchell, Edward P., 27839 Moise, Alexander R., 27815 Moran, Jason M., 28162 Moseley, James B., 28023 Motta, Iris, 28142 Moynagh, Paul N., 27759 Mu¨ller, Isabel M., 27949 Mu¨ller, Werner E. G., 27949 Mushinski, J. Frederic, 27728 Muzzolini, Laura, 28072 Nagai, Ryozo, 27523 Nagajyothi, 27850 Najima, Yuho, 27523 Nakagawa, Yoshimi, 27523 Nakamura, Shun-ichi, 27561 Nakamura, Takaaki, 27924 Nakayama, Keiichi I., 27866 Newton, Christopher S., 27872 Nishida, Takashi, 27638 Norris, F. A., 27508 Nozawa, Satoshi, 27544 O’Brien-Simpson, Neil M., 28095 Odintsov, Sergey G., 27792 Offterdinger, Martin, 27826 Oguma, Takemi, 27638 Ohashi, Ken, 27523 Ohno, Takatoshi, 27544 Ohta, Kazuki, 27561 Ojcius, David M., 28142 Okazaki, Hiroaki, 27523 Okazaki, Sachiko, 27523 Ono, Robert N., 27970 Ono, Takeshi, 27638 Osawa, Yosuke, 27879 Oscarson, Stefan, 27839 Osuga, Jun-ichi, 27523 Ottonello, Simone, 28044 Palczewski, Krzysztof, 27815 Pandey, Dharmendra, 27569 Paolini, Rita A., 28095 Pappa, Aglaia, 27998 Park, Hye-Jin, 27783 Park, Hyejin, 28061 Pavliv, Oleksandra, 27613 Pece-Barbara, Nadia, 27800 Pedersen, Lars C., 27990 Pepperkok, Rainer, 27826 Perovic´-Ottstadt, Sanja, 27949 Pessah, Marcia, 27645 Phillips, A. Marie, 27670 Pingoud, Alfred, 27990 Plattner, Helmut, 27960 Prager, Kai, 28110 Price, David A., 27491 Prieur, Xavier, 27533 Pushkarsky, Tatiana, 27866 Qian, Yong, 27888 Qin, Hongmin, 27688 Qin, Jun, 27631 Raetz, Christian R. H., 27679 Ramos-Castan˜eda, Jose, 27713 Ranganathan, Sripriya, 27872 Rao, K. Sudhindra, 27719 Rapoport, Tom A., 28127 Rawadi, Georges, 27645 Reed, Tiffany L., 27481 Repa, Joyce J., 28103 Resch, Klaus, 27728 Reynolds, Eric C., 28095 Robberecht, Patrick, 28034 Rodrı´guez, Joan C., 27533 Roh, Hee-Eun, 28061 Rohrbach, Petra, 27960 Roman-Roman, Sergio, 27645 Roobol, Anne, 28118 Rosenbaum, Joel L., 27688 Royer, William E., Jr., 27477 Rozanov, Dmitri V., 27755

Rybin, Vladimir, 27792 Sabala, Izabela, 27792 Sakai, Lynn Y., 27970 Sandelius, Anna Stina, 27578 Sandhoff, Konrad, 28110 Sato, Masaki, 27638 Savinov, Alexei Y., 27755 Sawa, Justyna, 27904 Sawaya, Michael R., 27769 Schaap, Frank G., 27533 Schmidt, Amy E., 27832 Schmidt, Walter K., 27481 Schneider, Heike, 27728 Schwabe, Robert F., 27879 Seeds, Andrew M., 27654 Sekiya, Motohiro, 27523 Senior, Alan E., 27981 Seo, Su Ryeon, 27645 Serna, Jannie S., 27662 Sewell, Andrew K., 27491 Shao, Yuanlong, 28118 Sharma, Sudha, 28072, 28085 Shaul, Philip W., 28103 Shekar, S. Chandra, 27850 Sherry, Barbara, 27866 Shetty, Sreerama, 28133 Shi, Yun-Bo, 27856 Shiau, Ai-Li, 27742 Shimano, Hitoshi, 27523 Shimizu, Katsuji, 27544 Shinjo, Katsuhiro, 27924 Shuntoh, Hisato, 27561 Siess, Wolfgang, 27569 Siron, Laura C., 27688 Skach, William R., 28118 Smith, Janet L., 27914 Snelgrove, Sarah L., 28095 Sommers, Joshua A., 28072 Spicer, Andrew P., 27513 Streb, Jeffrey W., 28007 Strickland, Dudley K., 27872 Strongin, Alex Y., 27755 Sturm, Jo¨rg W., 27826 Subramanian, Vivekanandan, 27935 Sugiura, Reiko, 27561 Suh, Dong-Chul, 28061 Sulochana, Konerirajapuram N., 27935 Sun, Feng, 27935 Sung, Rohyun, 27809 Suzuki, Masahiro, 27561 Tada, Kazuki, 27561 Tadakuma, Takushi, 27638 Taggart, W. David, 27688 Tagoh, Hiromi, 27552 Takeuchi, Yoshinori, 27523 Tamboli, Irfan Y., 28110 Tamura, Yoshiaki, 27523 Teer, Jamie K., 27624 Thakur, Narsinh L., 27949 Thiefes, Axel, 27728 Th’ng, John P. H., 27809 Tjellstro¨m, Henrik, 27578 Torrano, Vero´nica, 28152 Treinin, Millet, 28053 Tsai, Jui-Chen, 27742 Tsiomenko, Arnold B., 27613 Tsiros, John T., 28095 Tsujimoto, Kyoko, 27638 Turk, John, 28162 Uchinami, Hiroshi, 27879 Ushijima, Hiroshi, 27949 Uzdilla, Laura A., 28085 Vaisman, Iosif, 27866 Valasek, Mark A., 28103 van den Berg, Hugo A., 27491 Vanderwinden, Jean-Marie, 28034 Vanpouille, Christophe, 27866 Vasiliou, Vasilis, 27998 Veith, Paul D., 28095 Vera, Sonia, 27800 Vertongen, Pascale, 28034 Vindigni, Alessandro, 28072, 28085 Vinogradov, Evgeny, 27604 Vorum, Henrik, 27776 Wagner, Jessica S., 28127

x Wakahara, Kazuhiko, 27544 Wall, Adam A., 27670 Walter, Jochen, 28110 Weng, Jian, 28103 White, Carl, 27998 Whitfield, Chris, 27604 Wiens, Matthias, 27949 Wilken, Corinna, 27904 Wilson, Teresa M., 28085

Wimmerova´, Michaela, 27839 Wirth, Dagmar, 27728 Wohltmann, Mary, 28162 Wolter, Sabine, 27728 Wong, F. Susan, 27755 Wooldridge, Linda, 27491 Wrana, Jeffrey L., 27800 Wu, Chuanyue, 27631

Wu, Haiyan, 27850 Xu, Zhen, 27631 Yahagi, Naoya, 27523 Yam, Alice Y., 28118 Yamada, Nobuhiro, 27523 Yan, Chen, 27705 Yao, Wei-Jen, 27742

Yassin, Lina, 28053 Ye, Ming, 27809 Ye, Yihong, 28127 Yee, Vivien C., 27719 Yim, Tae-Hee, 27783 Yin, Guoyong, 27705 Yip, Shu-Chin, 27850 York, John D., 27654 Young, David B., 27587

Yu, Mi-Young, 28061 Yurchenko, Vyacheslav, 27866 Zeng, Yan, 27595 Zha, Xiliang, 27631 Zheng, Qinlei, 27705 Zhu, Hao, 27477 Zhu, Jianghai, 27914