Biography Julia White, MD Professor Director, Breast Radiation Oncology Vice Chair, Clinical Research Department of Radiation Oncology The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Rosemont College, Rosemont, PA B.A. Rosemont College, Rosemont, PA M.D. Michigan State University, East Lansing, MI William Beaumont Hospital, Royal Oak, MI Residency

1981, Biology 1988, Medicine 1988-1989, Rotating Internship 1989-1993, Radiation Oncology

Personal Statement I am a board certified Radiation Oncologist with specific expertise in breast cancer. I am involved in the development, execution, analysis, and oversight of clinical trials for breast cancer patients both within my own institution and nationally. I am currently the Chair of the Radiation Therapy Oncology Group (RTOG) Breast Cancer Committee and principal investigator for RTOG on a Phase III national clinical trial (NSABP B39 / RTOG 0413) enrolling 4300 early stage breast cancer patients. I am a voting member for the National Cancer Institute (NCI) Breast Cancer Steering Committee, NCI Breast Oncology Local Therapy Task Force, and a full member of the Susan G. Komen Scientific Advisory Council. These roles have provided me with a perspective on the current scientific and clinical priorities in breast cancer. My own research focuses on the development and implementation of novel radiation regimens for breast cancer patients. This has lead to my involvement in developing and authoring multiple consensus statements on the use of radiation therapy for breast cancer treatment. My clinical and research expertise in the area of breast cancer treatment will be extremely valuable for this project.

Positions and Honors Professional Experience 2012 – Present Professor and Vice Chair for Clinical Research for Radiation Oncology, The Ohio State University Wexner Medical Center 2008 – 2012 Professor Department of Radiation Oncology, Medical College of Wisconsin 2001 - 2008 Associate Professor Department of Radiation Oncology, Medical College of Wisconsin 1993 - 2001 Assistant Professor Department of Radiation Oncology, Medical College of Wisconsin 1993 - Present Active Staff: Froedtert Memorial Lutheran HospitalCommunity Memorial Hospital, Menomonee Falls 1993 - Present Consulting: Children's Hospital of Wisconsin, Clement Zablocki Veteran's Hospital

Professional Activities 1995 - 2001 Program Director: American Cancer Society (ACS) Medical Student Clinical Oncology Summer Clerkship, Medical College of Wisconsin 1995 - 2000 Clinical Research and Education Committee, ACS, (Wisconsin Division) 1995 - 2001 Patterns of Care Study (PCS), Breast Cancer Committee 2001 - 2005 Patterns of Care Study, Vice Chair Breast Cancer Committee 1997 - Present Chairman, Radiation Therapy Oncology Group (RTOG) New Investigators Committee 1998 - Present Program Director, for MCW Medical Student Short-Term Cancer Research Program 1999 - 2001 AACE (American Association of Cancer Education), Pre-Doctoral Education Committee, Vice-Chairman 2000 - Present Medical Director, Community Memorial Hospital Cancer Care Center 2001 - 2007 Section chair, Pre-Doctoral Education, American Association of Cancer Education 2002 - 2005 ACS (national) Institutional Research Grant Peer Review Committees 2004 - 2006 RTOG Breast Cancer Committee member 2005 - 2008 American College of Radiology Appropriateness Criteria, Breast Cancer Committee 2005 – Present NSABP Protocol B-39/RTOG Protocol 0413, RTOG Principal Investigator 2006 - 2007 Committee Chair, ACS (national) Institutional Research Grant Peer Review Committee 2006 Department of Defense USAMRMC Breast Cancer Research Program Peer Review Committee 2006 - 2007 Co-Chair, RTOG Breast Cancer Committee 2006 - Present Chair, Quality Research in Radiation Oncology (formerly PCS), Breast Cancer Committee 2006 - Chair, Susan G. Komen Foundation Scientific Peer Review Committee, Local Therapies 2007 - Present Oral Board Chair, Breast Category, American Board of Radiology 2007 – Present Chair, RTOG Breast Cancer Committee 2008 – Present Member, Susan G. Komen Foundation Scientific Peer Review Committee, Local Therapies 2008 – Present Member, Commission On Cancer, American College of Surgeons 2008 - Present Member, National Cancer Institute (NCI) Breast Cancer Steering Committee 2009 – 2010 Member, Task Force on Whole Breast Irradiation, Health Services Research Committee (ASTRO) 2009 – Present Member, North American Breast Cancer Groups (NABCG) 2009 - Present Member, Breast International Group (BIG)-NABCG Metastatic Working Group 2009 – Present President elect and Chair of 2010 Annual Meeting, AACE (American Association of Cancer Education) 2010 – Present Member, Susan G. Komen Scientific Advisory Council

Awards and Honors 1988 Alpha Omega Alpha, Michigan State University, MI. 1995 ESTRO/ASTRO Travel Grant Annual ESTRO Meeting, Paris, France 2005 Spirit of Caring Award, Contributions to the Medical Profession. Presented by Community Memorial Hospital, Advanced Healthcare, and Medical Associates. 2005-2010 Best Doctors in America

Selected Pertinent Peer-reviewed Publications 1. Ibbott G, Hanson W, Martin E, Kuske R, Arthur D, Rabinovitch R, WHITE J, Wilenzick R, Harris I, Tailor R. Dose specification and quality assurance of RTOG protocol 95-17; A cooperative group study of 192Ir breast implants as sole therapy. Int J Radiat Onc Biol Phy 69(5):1572-78, 2007. 2. Benitez P, Keisch M, Vicini F, Stolier A, Scroggins T, Walker A, WHITE J, Hedberg P, Hebert M, Arthur D, Zanniz V, Quiet C, Streeter O, Silverstein M. Five year results: The initial clinical tria of Mammosite balloon brachytherapy for partial breast irradiation in early stage breast cancer. Am J Surg 194(4):456-62, 2007. 3. Bovi J, Qu XS, WHITE J, Li XA. Comparison of three accelerated partial breast irradiation techniques: Treatment effectiveness based on biological models. Radiother Oncol 84(3):322632, 2007. 4. Kainz K, WHITE J, England M Li XA. Exploring helical tomotherapy for Simultaneously irradiating breast and regional node in prone position. Accepted to Int J Radiat Oncol Biol Phys 2007. 5. Ibbott, G Hanson W, O’Meara E, Kuske R, Arthur D, Rabinovitch R, WHITE J, Wilenzick R, Harris I, Tailor R. Dose Specification and Quality Assurance of Radiation Therapy Oncology Group Protocol 95- 17: A Cooperative Group Study of Iridium 192 Breast Implants as Sole Therapy. Int J Radiat Oncol Biol Phys, 69(5):1572-1578, 2007. 6. Arthur DW, Winter K, Kuske RR, Bolton J, Rabinovitch R, WHITE J, Hanson WF, Wilenzick RM, McCormick B. A Phase II Trial of Brachytherapy Alone Following Lumpectomy for Select Breast Cancer: Tumor Control and Survival Outcomes of RTOG 95-17. Int J Radiat Oncol Biol Phys, 72(2):467-473, 2008. 7. WHITE J, Halberg F, Rabinovitch R, Green S, Haffty B, Solin L, Strom E, Taylor M, Edge S. American College of Radiology Appropriateness Criteria™: Conservative Surgery and Radiation: Stages I and II Breast Carcinoma. J Am Coll Radiol 5(6): 701-713, June 2008 8. Li XA, Tai A, Arthur D, Buchholz T, MacDonald S, Marks L, Pierce L, Taghian A, Vicini F, Woodward W, WHITE J. Variability of target and normal structure delineation for breast cancer radiotherapy: A RTOG multi-institutional and multi-observer study. Int J Radiat Oncol Biol Phys, 73(3):944-951, 2009. [PMCID: PMC2911777] 9. Kainz, K, WHITE J, Herman J, Li XA. Investigation of Helical Tomotherapy for Partial-Breast Irradiation of Prone-Positioned Patients. Int J Radiat Oncol Biol Phys 74(1):275-282, 2009. 10. Taylor ME, Haffty BG, Rabinovitch R, Arthur DW, Halberg FE, Strom EA, WHITE JR, Cobleigh MA, Edge SB. ACR appropriateness criteria on postmastectomy radiotherapy expert panel on radiation oncology-breast. Int J Radiat Oncol Biol Phys 73(4):997-1002 Mar 2009. 11. Owen B, WHITE J, Zelefsky M, Wilson F. Using QRRO Survey Data to Assess Compliance With Quality Indicators for Breast and Prostate Cancer. J Am Coll Radiol 6(6):442-447, June 2009. 12. Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, WHITE J, Wo JY. Accelerated Partial Breast Irradiation

Consensus Statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys. 74(4):987-1001, 2009. 13. Qi XS, WHITE J, Sood A, Bauer A,Tao R, Wilson JF, Li XA. Respiratory organ motion and dosimetric impacts on breast and nodal irradiation. Int J Radiat Oncol Biol Phys. 78(2):609-17, 2010 14. Sparano JA, Pisano ED, WHITE JR, Hunt KK, Mamounas EP, Perez EA, Hortobagyi GN, Gralow JR, Comis RL. Recommendations for research priorities in breast cancer by the Coalition of Cancer Cooperative Groups Scientific Leadership Council: imaging and local therapy. Breast Cancer Res Treat. Apr;120(2):273-84, 2010 15. Smith BD, Bentzen SD, Correa CR, Hahn CR, Hardenbergh, Ibbott GS, McCormick B, McQueen JR, Pierce LJ, Powell SN, Recht A, Taghain AG, Vicini FA, WHITE JR, Haffty BG. Fractionation for whole breast irradiation: An American Society for Radiation Oncology (ASTRO) Evidence-based Guideline. Int J Radiat Oncol Biol Phys. 2010 Jul 15

Research Support ACTIVE (PI: Li) July 1, 2010 – June 30, 2012 Susan G. Komen Breast Cancer Foundation MRI-CT Guided Perioperative Partial Breast Irradiation The primary goal of this project is to develop and to test a preoperative PBI technique, an integrated novel approach to significantly change the current practice for RT of early stage breast cancer. Role: Co-PI U10 CA021661-33 (PI: Curran) January 1, 2009 – December 31, 2014 NIH/NCI Radiation Therapy Oncology Group (RTOG) The major goal of the RTOG is to conduct multicenter, multidisciplinary clinical trials that systematically test novel radiotherapy approaches against cancer. NSABP B-39 /RTOG 0413 (PI: White) January 2005 – present National Surgical Adjuvant Breast and Bowel Project (NSABP) A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I or II Breast Cancer The major goal is to determine that PBI is equivalent to WBI following lumpectomy in terms of in-breast cancer control for early stage breast cancer patients. NCI Grant CA216691-29 (White) 1997 – present RTOG New Investigators and Breast Committee The major goal is to facilitate the integration of New Investigators into RTOG activities in terms of patient ccrual and trial development.

COMPLETED IN LAST THREE YEARS: R25 CA59796-06 (PI: White) May 1, 1998 – April 30, 2008 NIH Cancer Education Program Grant The major goal is to provide sound short-term cancer research experiences to medical students. BCTR0504070 (PI: White) May 1, 2005 - May 1, 2007 Susan G. Komen Breast Cancer Foundation Intensity Modulated Radiotherapy for Treatment of Breast Cancer Patients in the Prone Position The major goal to develop partial breast irradiation and nodal irradiation in the prone position to reduce normaltissue toxicity.