1 CURRICULUM VITAE Name:

Douglas R. Green

Address:

St. Jude Children’s Research Hospital Dept. Immunology 332 N. Lauderdale St. Memphis, TN 38105 +1-901-595-3378 [email protected]

Telephone: eMail: Education:

Institution

Degree

Date

Yale Univ. M.I.T. Yale Univ.

B.S. (Biology) none Ph.D. (Biology)

1977 1977-1978 1981

Magna cum laude Yale Univ. Distinction in Biology Yale Univ. E.J. Boell Award (Biology) Yale Univ. J.S. Nicholas Award (Zoology) Yale Univ. Alberta Heritage Scholar AHFMR Outstanding Teacher Award Univ. Alberta “Hottest” Science (Science, 275, 1573, 1997) Ashland Public School System Hall of Fame Ashland, MA ISI apoptosis (ranked in top 6 laboratories for total citations, total publications, and citations per publication) MERIT Award, NIGMS ISI “highly cited” International Cell Death Society Prize Honorary Fellow Trinity College, Dublin Einstein Professorship China

1977 1977 1977 1981 1985-1990 1990 1995-1996 1998 1991-2001

Honors:

2002 2003 2009 2010 2011

Special Lectures: Dalmer Lecture, Univ. Brit. Col. Hume Lecture, Am. Soc. Transpl. Surg. Chicago State of the Art Lecture, Amer. Soc. Nephrology, Boston Keynote Address, Keystone Symp. on Mol. Mechs. of Apoptosis Keynote Address, Gordon Res. Conf. on Cell Death Keynote Address, International Cytokine Society Keynote Address, Cancer Biology Retreat, MD Anderson Chair and Speaker, Major Symposium AAI Chair and Speaker, Major Symposium ASBMB BMRC Distinguished Visitor, Singapore Distinguished Lecturer, Northwestern Univ. Cancer Center AACR Annual Meeting, “Meet the Expert” AACR Annual Meeting, “Meet the Expert” Falk Memorial Lecture, NIEHS Ishizaka Lecture, LIAI, San Diego

1997 1997 1999 2001 2001 2001 2002 2002 2002 2003 2003 2004 2005 2006 2007

2 Hans Popper State of the Art Lecture, AASLD, Boston State of the Art Lecture, Amer. Coll. Rheumatol., Boston Giacchino Lecture, Thomas Jefferson Univ. Keynote Address, Apoptosis 2008, Luxembourg Keynote Lecture, International Worshop on p63/p73 AACR Annual Meeting, “Meet the Expert” Lewis Thomas Lecture, NYU Gershon Lecture, Yale Univ. Keynote Lecture, MCRC Conference, Manchester, UK Keynote Lecture, Signaling 2000, Rio de Janeiro AACR Annual Meeting, “Meet the Expert” Keynote Lecture, FASEB Biology of Calpains Hamilton Lecture, Temple Univ. Sch. Med., Philadelphia Keynote Lecture, Int. Congress Cell Biol., Rio de Janeiro Keynote Lecture, Keystone Meeting on Immune Plasticity Keynote Lecture, Keystone Meeting on Autophagy Keynote Lecture, FASEB Meeting on Mitochondria Keynote Lecture, GRS Meeting on Clearance of Dying Cells Susan Cooper Jones Memorial Lecture, Huntsman Cancer Ctr. Keynote Lecture, EACR Cell Death in Cancer, Amsterdam Keynote Lecture, Challenges & Sol. in Cancer, Rio de Janeiro.

2007 2007 2008 2008 2009 2009 2009 2009 2010 2010 2010 2010 2012 2012 2013 2013 2013 2013 2013 2014 2014

Employment: 2005-Present 1994-2005 1990-2005 1991-1993 1989-1991 1987-1991 1985-1987 1984-1985 1983-1984 1983-1984 1982 1981 1981-1983

Peter C. Doherty Endowed Chair of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Adjunct Professor, Dept. Biology, University of California, San Diego Member and Head, Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA. Adjunct Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta Tenured (University Position), Dept. Immunology, Univ. Alberta, Edmonton, Alberta. Associate Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta. Assistant Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta. Associate Research Biologist (nontenure faculty), Dept. of Biology, Yale University Research Associate, Departments of Pathology and Surgery, Yale University. Acting Co-Director, Laboratory of Dr. R.K. Gershon, Dept. Pathology, Yale University. Academic Fellow, Yale College. Academic Fellow, Yale College. Post-Doctoral Fellow, Dept. Pathology, Yale University.

Societies: American Association of Immunologists American Association for Cancer Research Professional Activities Study Sections: NIH (CMIB, Chair) NIH (PathC, renamed CAMP) NIH-NCI Site Visit NIH (IMB, Ad hoc)

2007-2009 2001-2005 1995, 1998 1995, 1997

3 ACS (Cell Biology) NIH-NEI (Vis C, Ad hoc) MRC Site Visit NIH Site Visit (MBRS Program)

1994 1994 1992 1991

Grants Panels (CANADA): AHFMR Fellowship Panel NCIC Grants Panel A CARS Manpower Panel

1987 1988-1991 1989

Canada Research Chair, College Member

2000-

Organizing Committees: Intl. Congr. Immune Consequences of Shock, Trauma and Sepsis, Munich, W. Germany 19th Intl. Leukocyte Culture Conference Workshop on Immune Tolerance and Suppression IBC Meeting on Apoptosis Vice-chair, Gordon Conf. on Cell Death AACR Apoptotis Symposium AACR Annual Meeting 2013 Chair, Gordon Conf. on Cell Death Co-chair, Keystone Conf. on Apoptosis ASBMB Annual Meeting SASS Fdn Workshop on Apoptosis and Infection TNF Superfamily Conference International Congress of Immunology Chair, Keystone Conf., Cell Death and Senescence Chair, Keystone Conf., Cell Death in the Immune System AACR Annual Meeting, Co-chair Program Comm. AACR Annual Meeting, Co-chair Program Comm. CSHL Cell Death Meeting, co-chair Co-Chair, Keystone Conf., Metabolism and inflammation Chair, CSHL Cell Death Meeting AACR Annual Meeting, Co-chair program Comm. Co-Chair, Keystone Conf., Cell Death Signaling, Brazil

1988, 1991, 1994, 1997 1988 1993, 1995, 1997 1995 1997 1998 1998, 1999, 2002, 2005, 2012, 1999 2001 2002 2002 2002 2004 2005 2008 2008 2009 2011 2013 2013 2014 2014

Journals: Editor in Chief, Oncogene US Editorial Office, Cell Death Diff. Senior Editor, Cancer Research Senior Editor, Molecular Cancer Research Associate Editor, Immunological Reviews Associate Editor, Cytokines Associate Editor, J. Exp. Zool. Associate Editor, J. Clin. Immunol. Associate Editor, J. Biol. Chem. Editorial Board, DNA Cell Biol. Editorial Board, Molecular Cell Editorial Board, Neoplasia Editorial Board, Cancer Cell Editorial Board, BMC Immunology

2009-Present 1994-2009 2002-2005 2006-2009 2002-2006 1989-Present 1989-2002 1996-Present 1997-2001 1998-Present 1998-Present 1998-Present 2002-Present 2004-Present

4 Transmitting Editor, International Immunology 2001-2005 Editorial Board, Mol. Cell Biol. Editorial Board, J. Cell Sci. Editorial Board, Autophagy Editorial Board, Cell

2007-Present 2007-Present 2007-Present 2008-Present

Regular reviewer for the following journals: Cell, Molecular Cell, Developmental Cell, Cancer Cell, Neuron, Immunity, Nature, Nature Cell Biology, Nature Immunology, Science, J. Cell Biol., J. Exp. Med., J. Biol. Chem., PNAS, Cell Death Diff. Chairman Search Committee, Immunology, Univ. Alberta Director Search Committee, La Jolla Inst. Allergy Immunol. Faculty Search Committee, La Jolla Inst. Allergy Immunol.

1988 1993-1994 1995-1998, 2002-

Institutional Animal Care Committee Chairman, Animal Care Committee

Univ. Alberta LIAI

1989-1990 1990-1997

Scientific Advisory Boards: Maxim Pharmaceuticals Cytovia Pharmaceuticals (Chair) Eirx Pharmaceuticals Keystone Symposia Lycera Aeleron Boston, MA

San Diego, CA San Diego, CA Cork, Ireland Keystone, CO Ann Arbor, MI 2009-2010

2002-2005 1999-2002 2001-2002 2005-2012 2008-2010

Awards and Contracts Alberta Heritage Found. for Medical Research

Establishment Grant

1985

SciCan Diagnostic (grant)

Lymphocyte Separation

1986

Central Res. Fund, Univ. Alberta

Burns and Immunity

1986

Canadian Found. Illeitis and Colitis

Bacterial Sepsis and Immunity

1987-89

Med. Res. Council of Canada

Antigen-specific T cell factors

1987-89

Arthritis Soc. Canada

T Cell Response to Collagen II (with A. Fotedar, coPI)

1987-89

Med. Res. Council of Canada

Inhibitory Lymphokines in Thermal Trauma

1989-1992

Med. Res. Council of Canada

Antigen-specific T Cell Factors

1989-90

MS Soc. Canada

Regulation of EAE (with A. Salmi, coPI)

1989-91

Arthritis Soc. Canada

T Cell Response to Collagen II (with A. Fotedar, coPI)

1989-91

Ortho Biotech (Contract)

Trauma Induced Suppressive Cytokine

1989-90

Med. Res. Council of Canada

Antigen Specific T Cell Factors

1990-1992

Natl. Cancer Inst. Canada

Activation-Induced Cell Death in

1990-1992

5 the Immune System

US Natl. Inst. Health (R01GM52735, formerly R01AI31591)

Stress-Induced Apoptosis in T Cells

1991-2012 (MERIT award, 2002)

Amer. Cancer Soc. (CB-82)

Oncogene Interactions in Apoptosis

1993-1998

US Natl. Inst. Health (P01CA69381)

1996-2010

J. Reed, PI

Mechanisms of Bcl-2 family function in apoptosis (Comp. IV of Signal Transduction and Apoptosis)

US Natl. Inst. Health (P60AR40770)

p53, Apoptosis and Chronic Rheumatoid Arthritis

1997-2000

US Natl. Inst. Health (R01AI40646)

Central Mechanisms of Apoptosis in the Immune System

1997-2012

US Natl. Inst. Health (R01AI44828)

Survival function of the FADDcaspase-8-FLIP complex

1999-2017

Originally: Activation-induced cell death in T lymphocytes

Pfizer Pharmaceuticals (contract)

Fas-FasL interactions in neurodegeneration

1999-2001

US Natl. Inst. Health (R01AI47891)

Activation and function of caspase-2

2000-2015

Leukemia Lymphoma Soc. (SCOR-T. Mak, PI)

A Novel Mechanism of p53 Mediated Tumor Suppression

2004-2009

US Natl. Inst. Health (R21AI059850)

Immune Tolerance Induction by Apoptotic Bodies

2004-2006

US Natl. Inst. Health R01-GM096208

BCL-2 family interactions in apoptosis.

2010-2014

US Natl. Inst. Health R01-CA169291

RIPK-dependent necrosis in development and cancer

2012-2017

6 Douglas R. Green

PUBLICATIONS 1.

Gershon, R. K., Eardley, D. D., Green, D. R., Shen, F. W., Yamauchi, K., Cantor, H., and Murphy, D. B. Contrasuppression: A novel immunoregulatory activity. J. Exp. Med. 153:1533-1546, 1981.

2.

Green, D.R., Gershon, R.K. and Eardley, D.D. Ly-2 suppressor T lymphocytes directly inactivate different functional subsets of Ly-1 T cells. Proc. Natl. Acad. Sci. (USA) 78:3819-3823, 1981.

3.

Green, D.R. and Eardley, D.D. Modeling a continuum of immune responsiveness. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 673-686.

4.

Green, D.R., Eardley, D.D., Kimura, A., Murphy, D.B., Yamauchi, K. and Gershon, R.K. Immunoregulatory circuits that modulate responsiveness to suppressor cell signals: Identification of the effector cell of the contrasuppressor circuit. Eur. J. Immunol. 11:973-980, 1981.

5.

Green, D.R. and Gershon, R.K. The immunologic orchestra. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 893-896.

6.

Janeway, C. A., Broughton, B., Dzierzak, E., Jones, B., Eardley, D. D., Durum, S. K., Yamauchi, K., Green, D. R., and Gershon, R. K. Studies of T lymphocyte function in B cell deprived mice. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 661-671.

7.

Kupper, T.S., Green, D.R., Chaudry, I.H., Clemens, M.G. and Baue, A.E. Restoration of the depressed immune response after burn injury with low dose cyclophosphamide. Surgical Forum 32:60-61, 1981.

8.

Ptak, W., Green, D.R., Durum, S.K., Kimura, A., Murphy, D.B. and Gershon, R.K. Immunoregulatory circuits that modulate responsiveness to suppressor cell signals: Contrasuppressor cells can convert an in vivo tolerogenic signal into an immunogenic one. Eur. J. Immunol. 11:980-983, 1981.

9.

Yamauchi, K., Eardley, D.D., Green, D.R., Murphy, D.B. and Gershon, R.K. Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: The failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit. J. Exp. Med. 153:1547-1561, 1981.

10.

Fox, A.D., Chaudry, I.H., Kupper, T.S., Green, D.R., Clemens, M.G. and Baue, A.E. Restoration of the depressed immune response following burn injury by administration of ATP-MgCl2 or tuftsin. Surgical Forum 33:69-71, 1982.

11.

Green, D.R. and Gershon, R.K. Hyperimmunity and the decision to be intolerant. Ann.N.Y.Acad.Sci. 392:318-329, 1982.

12.

Green, D.R. and St. Martin, S. Suppression and contrasuppression in the regulation of gut associated immune responses. Ann.N.Y.Acad.Sci. 409:284-291, 1982.

13.

Green, D.R., Gold, J.A., St. Martin, S., Gershon, R. and Gershon, R.K. Microenvironmental immunoregulation: The possible role of contrasuppressor cells in maintaining immune responses in gut associated lymphoid tissue (GALT). Proc. Natl. Acad. Sci. (USA) 79:889-892, 1982.

14.

Green, D.R. Contrasuppression: Its role in immunoregulation. In: The Potential Role of T Cell Subpopulations in Cancer Therapy, edited by Fefer, A. and Goldstein, A.L. New York: Raven Press, 1982, p. 279-290.

15.

Smith, H.R., Green, D.R., Raveche, E.S., Smathers, P.A.,, Gershon, R.K. and Steinberg, A.D. Studies of the induction of anti-DNA in normal mice. J. Immunol. 129:2332-2334, 1982.

7 16.

Yamauchi, K., Tanaguchi, M., Green, D.R. and Gershon, R.K. The use of a monoclonal anti-I-J antibody to distinguish cells in the feedback suppression circuit from those in the contrasuppressor circuit. Immunogenetics 16:551-558, 1982.

17.

Green, D.R. and Gershon, R.K. Contrasuppression, Class I antigens, and cancer immunity. In: Haematology and Blood Transfusion V. 28, Trends in Human Leukemia, V, edited by Neth,, Gallo, R.,, Greaves, M.,, Moore, and Winkler. New York: Springer-Verlag, 1983, p. 479-485.

18.

Green, D.R. and Gershon, R.K. A view from the bridge: Antigenic determinants in immunoregulation. In: Protein Conformation as an Immunological Signal, edited by Celada, F.,, Schumacher, V., and Sercarz, E. New York: Plenum Press, 1983, p. 387-394.

19.

Green, D.R., Flood, P.M. and Gershon, R.K. Immunoregulatory T cell circuits. Ann. Rev. Immunol. 1:439-463, 1983.

20.

Green, D.R. Immunoregulation by contrasuppressor T cells. EOS Riv. Immunol. Immunofarm. 3:155161, 1983.

21.

Green, D.R., Chue, B. and Gershon, R.K. Two types of T cell suppression discriminated by cell surface phenotype and by function: The ability to regulate the generation of contrasuppression. J. Mol. Cell. Immunol. 1:19-28, 1983.

22.

Iverson, G.M., Ptak, W., Green, D.R. and Gershon, R.K. The role of contrasuppression in the adoptive transfer of immunity. J. Exp. Med. 158:982-987, 1983.

23.

Smith, H.R., Green, D.R., Raveche, E.S., Smathers, P.A., Gershon, R.K. and Steinberg, A.D. Induction of autoimmunity in normal mice by thymectomy and administration of polyclonal B cell precursors: Association with contrasuppressor function. Clin. Exp. Immunol. 51:579-586, 1983.

24.

Flood, P.M., Gershon, R.K. and Green, D.R. Information transfer between T cell sets. I-J+ molecules which act as carriers for regulatory signals. Prog. Immunol. 5:567-580, 1984.

25.

Fusi, S., Kupper, T.S., Green, D.R. and Aryan, S. Reversal of post-burn immunosuppression by the administration of Vitamin A. Surgery 96:330-335, 1984.

26.

Green, D.R. and Sercarz, E.E. Workshop summary: Immune networks and circuits. In: Regulation of the Immune System, edited by Cantor, H., Chess, L. and Sercarz, E.E. New York: Alan R. Liss, Inc., 1984, p. 801-805.

27.

Green, D.R. The stratified structure of immune regulation. In: Regulation of the Immune System, edited by Cantor, H., Chess, L. and Sercarz, E.E. New York: Alan R. Liss, Inc., 1984, p. 735-745.

28.

Green, D.R., Horowitz, M., Ferguson, T.A., Chue, B. and Flood, P.M. Immunoregulatory T cell pathways: The helper T cell clone as target. Asian Pac. J. Alergy Immunol. 2:318-324, 1984.

29.

Green, D.R. and Gershon, R.K. Contrasuppression: The second law of thymodynamics, revisited. Adv. Cancer Res. 42:277-335, 1984.

30.

Green, D.R. T8+ augmenting cells: Contrasuppression in man?. J. Mol. Cell. Immunol. 1:111-113, 1984.

31.

Kupper, T.S. and Green, D.R. Immunoregulation after thermal injury: Sequential appearance of IJ+,Ly-1+,2- T suppressor-inducer cells and Ly-1-,2+ T suppressor-effector cells following thermal trauma in mice. J. Immunol. 133:3047-3053, 1984.

32.

Kupper, T.S., Green, D.R., Chaudry, I.H., Fox, A.D. and Baue, A.E. A cyclophosphamide sensitive suppressor T cell circuit following thermal trauma. Surgery 95:699-706, 1984.

8 33.

Ptak, W., Bereta, M., Ptak, M., Gershon, R.K. and Green, D.R. Regulatory T cell interactions with an antigen-specific T contrasuppressor factor in contact sensitivity: Eradication of the tolerant state. J. Immunol. 133:1124-1130, 1984.

34.

Ptak, W., Bereta, M., Ptak, M., Gershon, R.K. and Green, D.R. Production of antigen-specific contrasuppressor cells and factor and their use in augmentation of cell mediated immunity. J. Immunol. 133:623-628, 1984.

35.

Van Lovern, H., Kato, K., Meade, R., Green, D. R., Horowitz, M., Ptak, W., and Askenase, P. W. Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity. J. Immunol. 133:2402-2411, 1984.

36.

Buss, L.W. and Green, D.R. Histocompatibility in vertebrates: The relict hypothesis. Dev. Comp. Immunol. 9:191-202, 1985.

37.

Buss, L.W., Moore, J.L. and Green, D.R. Autoreactivity and self tolerance in an invertebrate. Nature 313:400-402, 1985.

38.

Flood, P.M., Chue, B. and Green, D.R. Control of immune responsiveness by regulatory T lymphocytes. In: Concepts in Immunopathology, Vol. 3, edited by Cruise, J.M. and Lewis, R.E. Basel: Karger Press, 1985, p. 17-37.

39.

Green, D.R., Chue, B., Ferguson, T.A., Beaman, K.D. and Flood, P.M. Production of an antigenspecific component of suppressor inducer factor by a helper T cell clone: Possible role of IL-1 at the interface of immunity and tolerance. Br. J. Rheumatol. 24 (Suppl. 1), 105-111, 1985.

40.

Kupper, T.S. and Green, D.R. In vivo exposure to IL-1 or ETAF causes a loss in antigen-presenting cell function. Br. J. Rheumatol. 24 (Suppl. 1), 98-101, 1985.

41.

Kupper, T.S., Green, D.R., Durum, S.K. and Baker, C.C. Defective antigen presention to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery 98, 199-206, 1985.

42.

Kupper, T.S., Baker, C.C., Ferguson, T.A. and Green, D.R. A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J. Surg. Res. 38, 606-612, 1985.

43.

Ptak, W., Bereta, M., Iverson, G.M., Ptak, M. and Green, D.R. Suppression and contrasuppression in the induction of contact sensitivity by the administration of cell-bound antigen-antibody complexes. J. Immunol. 135, 2312-2318, 1985.

44.

Flood, P.M., Ptak, W. and Green, D.R. Mechanism of action of a T suppressor factor in contact sensitivity: Characterization of the T cell target for TsF activity in adoptive transfer of immunity. J. Immunol. 137, 1829-1835, 1986.

45.

Green, D.R. and Ptak, W. Suppressor and contrasuppressor T cell circuits and their relevance to diabetes. In: The Immunology of Diabetes Mellitus, edited by Jawarski, M.A., Molnar, G.D., Rajotte, R.F. and Singh, B. Amsterdam: Excerpta Medica, 1986, p. 411-416.

46.

Green, D.R. Contrasuppressor T cells: A practical guide to the identification of contrasuppressive effects in immunoregulatory systems. In: Handbook of Experimental Immunology, edited by Herzenberg, L.A. and Weir, D.M. Oxford: Blackwell Scientific, 1986, p. 1-9.

47.

Green, D.R. and Ptak, W. Contrasuppression, an immunoregulatory T cell activity. I. In the mouse. Immunol. Today 7, 81-86, 1986.

9 48.

Ptak, W., Green, D.R. and Flood, P.M. Cellular interactions in the adoptive transfer of contact sensitivity: Characterization of an antigen nonspecific, Vicia villosa adherent T cell needed for adoptive transfer into naive recipients. J. Immunol. 137, 1822-1828, 1986.

49.

Suzuki, I., Kitamura, K., Kiyono, H., Kurita, T., Green, D.R. and McGhee, J.R. Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. J. Exp. Med. 164, 501-516, 1986.

50.

Suzuki, I., Kiyono, H., Kitamura, K., Green, D.R. and McGhee, J.R. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T cell networks in the mucosal immune system. Nature 320, 451-454, 1986.

51.

Chaouat, G., Kolb, J-P., Chaffaux, S., Riviere, M., Athanassakis, I., Green, D. R., and Wegmann, T. G. The placenta and the survival of the fetal allograft. In: Immunoregulation and Fetal Survival, edited by Gill, T.J. and Wegmann, T.G. New York: Oxford University Press, 1987, p. 239-251.

52.

Eldridge, J. H., Kiyono, H., Suzuki, I., Kitamura, K., Kurita, T., Beagley, K. W., Michalek, S. M., Green, D. R. and McGhee, J. R. Regulatory T cell networks in the secretory immune system. In: Mucosal Immunology, edited by Mestecky, J., McGhee, J.R., Bienenstock, J. and Ogra, P. New York: Plenum Press, 1987, p. 45-55.

53.

Green, D.R., Chue, B., Zheng, H., Ferguson, T.A., Beaman, K.D. and Flood, P.M. A helper T cell clone produces an antigen-specific molecule (TABM) which functions in the induction of suppression. J. Mol. Cell. Immunol. 3, 95-108, 1987.

54.

Green, D.R., Zheng, H. and Wang, N. A T suppressor inducer factor from burn associated T cells. J. Burn Care Rehab. 8, 521-526, 1987.

55.

Green, D.R., Marcotte, R., Wang, N. and Zheng, H. Immunoregulatory T cells and immunodeficiency. In: Immunology and Oncology of Down's Syndrome, edited by McCoy, E.E. and Epstein, C. New York: Raven Press, 1987, p. 183-190.

56.

Green, D.R. and Wegmann, T.G. Beyond the immune system: The immunotrophic role of T cells in organ generation and regeneration. Prog. Immunol. 6, 1100-1112, 1987.

57.

Kitamura, K., Kiyono, H., Eldridge, J.H., Green, D.R. and McGhee, J.R. Effector contrasuppressor T cells which abrogate oral tolerance are distinct from both helper (L3T4+) and suppressor (Ly-2+) T cells. J. Immunol. 139, 3251-3259, 1987.

58.

Kitamura, K., Suzuki, I., Kiyono, H., Kurita, T., Berry, A. K., Green, D. R., and McGhee, J. R. Isotype specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance. In: Mucosal Immunology, edited by Mestecky, J., McGhee, J.R., Bienenstock, J. and Ogra, P. New York: Plenum Press, 1987, p. 143-148.

59.

Mogil, R.J., Green, D.R. and Wegmann, T.G. Immunotrophism at the maternal-fetal interface. In: Immunologie de la Reproduction: Relation Materno-Foetale, edited by Chaouat, G. Paris: INSERM, 1987, p. 113-120.

60.

Mogil, R.J., Patton, C.L. and Green, D.R. Cellular subsets involved in cell-mediated immunity to murine Plasmodium yoelii 17X malaria. J. Immunol. 138, 1933-1939, 1987.

61.

Cone, R.E., Zheng, H., Chue, B., Beaman, K., Ferguson, T. and Green, D.R. T cell-derived antigen binding molecules (TABM): Molecular and functional properties. Intern. Rev. Immunol. 3, 205-228, 1988.

62.

Green, D.R., McGhee, J.R. and Ptak, W. Contrasuppression and the control of microenvironmental immune responses. In: Mucosal Immunobiology, edited by Hanson, L. Basel: Karger Press, 1988, pp. 236-243.

10 63.

Green, D.R., Chue, B. and Flood, P.M. The induction of contrasuppression is restricted by genes mapping to the Igh locus. Immunol. Res. 7, 82-92, 1988.

64.

Green, D.R. Regulatory T cell function, antigen recognition, and an immunological decision point. In: The Semiotics of Cellular Communication in the Immune System, edited by Sercarz, E.E., Celada, F., Mitchison, N.A. and Tada, T. Berlin: Springer-Verlag, 1988, p. 245-256.

65.

Kiyono, H., Green, D.R. and McGhee, J.R. Contrasuppression in the mucosal immune system. Immunol. Res. 7, 67-81, 1988.

66.

Mogil, R.J., Patton, C.L. and Green, D.R. An immunogenic antigen of murine Plasmodium yoelii 17X associates with Class I MHC glycoproteins. J. Immunol. 141, 258-264, 1988.

67.

Ptak, W., Friedman, A., Bereta, M., Marcinkiewicz, J., Horvat, B, Reuter P, Green, D.R., and Flood, P.M. The role of contrasuppressor T cells in the adoptive transfer of contact sensitivity responses to picryl chloride. Immunol. Res. 7, 1-11, 1988.

68.

Ptak, W., Janeway, C.A., Flood, P.M., Marcinkiewicz, J. and Green, D.R. Immunoregulatory effects of cell-bound antigen-antibody complexes: Requirements for the induction of hapten-specific T contrasuppressor cells. J. Immunol. 141, 756-764, 1988.

69.

Wegmann, T.G., Fotedar, A. and Green, D.R. Immunotrophism and fetal survival. In: Perspectives in Immunoreproduction, edited by Mathur, S. and Fredericks, C.M. Washington: Hemisphere Pub. Co., 1988, p. 359-387.

70.

Zheng, H., Boyer, M., Fotedar, A., Singh, B. and Green, D.R. An antigen-specific helper T cell hybridoma produces an antigen-specific suppressor-inducer molecule: Implications for the antigen recognition and function of helper and suppressor-inducer T cells. J. Immunol. 140, 1351-1358, 1988.

71.

Green, D.R., and Faist, E. Trauma and the immune response. Immunol. Today, 9, 253-256, 1988.

72.

Chue, B., Beaman, K.D., Rosenman, S.J., Cone, R.E., Flood, P.M. and Green, D.R. An approach to the unification of suppressor T cell circuits. A simplified assay for the induction of suppression by T-cell derived, antigen binding molecules (TABM). Cell. Immunol. 118, 30-40, 1989.

73.

Friedman, A.M., Ptak, W., Freedman, J., Green, D.R. and Flood, P.M. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. In: Immunity to Cancer. II, edited by Mitchell, M.S. New York: Alan R. Liss, 1989, p. 281-288.

74.

Green, D.R., Marcotte, R. and Wang, N. The role of inhibitory T cells in burn trauma-associated immunodeficiency. In: The Immune Consequences of Shock, Trauma, and Sepsis, edited by Faist, E., Ninnemann, J.N. and Green, D.R., Springer-Verlag, Berlin, 1989, pp. 55-62.

75.

Green, D.R., Friedman, A., Ptak, W., McGhee, J.R. and Flood, P.M. Contrasuppression, tolerance, and tumor immunity. In: Immunity to Cancer. II, edited by Mitchell, M.S. New York: Alan R. Liss, 1989, p. 245-258.

76.

Sadelain, M.W.J., Voralia, M., Green, D.R. and Wegmann, T.G. The role of natural suppressor and natural killer activities in resistance to hemopoietic transplantation in unirradiated hosts. J. Immunol. 1989, 142, 2270-2278.

77.

Sadelain, M.W.J., Voralia, M., Green, D.R. and Wegmann, T.G. Mechanisms that determine host resistance to bone marrow stem cell engraftment in unirradiated hosts. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, Inc., 1989, p. 229-235.

11 78.

Sahai, B.M., Serra, H.M., Green, D.R. and Kaplan, J.G. Interleukin 2-induced Tac gene expression and proliferation in resting human T lymphocytes are monocyte dependent. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, 1989, p. 283-288.

79.

Zheng, H., Fotedar, A., Singh, B. and Green, D.R. An antigen-specific immunoregulatory activity from a helper T cell hybridoma: Possible relationship to the T cell receptor. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, Inc., 1989, p. 379-382.

80.

Zheng, H., Sahai, B.M., Kilgannon, P., Fotedar, A. and Green, D.R. Specific inhibition of cell-surface T cell receptor expression by antisense oligonucleotides and its effect on the production of an antigenspecific regulatory T cell factor. Proc. Natl. Acad. Sci. (USA) , 86, 3758-3762, 1989.

81.

Shi, Y., Sahai, B.M., and Green, D.R. Cyclosporin A inhibits activation-induced cell death in T cell hybridomas and in thymocytes. Nature, 339, 625-626, 1989.

82.

Green, D.R. and Zheng, H. Antigen-specific regulatory T cell factors and the T cell receptor. Ann. Inst. Pasteur, 140, 294-298, 1989.

83.

Kiyono, H., Kohtaro, F., Green, D.R., and McGhee, J.R. The mucosal immune system: possible roles for contrasuppression in normal and abberant IgA responses. In: Molecular Aspects of Human Disease, edited by Gorrd, Albano, and Papa, Ellis Horwood LTD, W. Sussex, 1989, pp. 229-239.

84.

Beagley, K.W., Fujihashi, K., Aicher, W., Xu, J., Kiyono, H., Eldridge, J.H., Bruce, M.G., Taguchi, T., Green, D.R., Singh, B., and McGhee, J.R. Mucosal homeostasis: Role of interleukins, isotypespecific factors, and contrasuppression in the IgA response. Immunol. Invest., 18, 77-89, 1989.

85.

Friedman, A.M., Ptak, W., Freedman, J., Green, D.R., and Flood, P.M. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. Prog. Clin. Biol. Res., 288, 282-288, 1989.

86.

Fujihashi, K., Kiyono, H., Aicher, W.K., Green, D.R., Singh, B., Eldridge, J.H., and McGhee, J.R. Immunoregulatory function of CD3+, CD4-, and CD8- T cells: γδ TCR-positive T cells from nude mice abrogate oral tolerance. J. Immunol., 143, 3415-3422, 1989.

87.

Green, D.R., and Kaufman, J. The evolution of the MHC. In: Defense Molecules, edited by J.J. Marchalonis and C. Reinish, Alan Liss, New York, 1990, pp. 119-124.

88.

Shi, Y., Szalay, M.G., Paskar, L., Sahai, B.M., Boyer, M., Singh, B., and Green, D.R. Activationinduced cell death in T cell hybridomas is due to apoptosis: Morphological aspects and DNA fragmentation. J. Immunol., 144, 3326-3333, 1990.

89.

Sadelain, M.J., Green, D.R., and Wegmann, T.G. Host natural suppressor activity regulates hemopoietic engraftment in antibody conditioned recipient mice. J. Immunol., 144, 1729-1736, 1990.

90.

Fujihashi, K, Taguchi, T., McGhee, J.R., Eldridge, J.H., Bruce, M.G., Green, D.R., Singh, B., and Kiyono, H. Regulatory function for murine intraepithelial lymphocytes: Two subsets of CD3+, T cell receptor - 1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J. Immunol., 145, 2010-1019, 1990.

91.

Friedman, A.M., Ptak, W., Brewer, E., Green, D.R., Reuter, P.A., and Flood, P.M. Generation of a T cell hybridoma producing a contrasuppressor factor for contact sensitivity. Immunology, 71, 282-289, 1990.

92.

Leddy, S.V., and Green, D.R. Historecognition in the Cnidaria. In: Phylogenesis of Immune Function, edited by G. Warr and N. Cohen, CRC Press, Boca Ratan, 1991, pp 103-116.

12 93.

Green, D.R. and Shi, Y. Activation-induced cell death in developing T cells and T cell hybridomas. Adv. Struct. Biol. 1, 287-300, 1991.

94.

Bissonnette, R., Zheng, H., Kubo, R., and Green, D.R. A helper T cell hybridoma produces an antigen-specific regulatory activity. Relationship to the T cell receptor by serology and antigenic finespecificity. J. Immunol., 146, 2898-2907, 1991.

95.

Shi, Y., Bissonnette, R.P., Parfrey, N., Szalay, M., Kubo, R.T., and Green, D.R. In vivo administration of antibodies to the CD3-T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146, 3340-3346, 1991.

96.

Green, D.R., Bissonette, R., Zheng, H., Onda, T., Echeverri, F., Mogil, R.J., Steele, J.K., Voralia, M., and Fotedar, A. Immunoregulatory activity of the T cell receptor α chain demonstrated by retroviral gene transfer. Proc. Natl. Acad. Sci. (USA), 88, 8475-8479, 1991.

97.

Cotter, T.G., Lennon, S., Glynn, J.M., and Green, D.R. Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res., 52, 997-1005, 1992.

98.

Green, D.R., and Flood, P.M. Contrasuppression. In: Roitt, I.M. and Delves, P.J. (eds) Encyclopedia of Immunology, Saunders Scientific Pub, London. pp. 300-303, 1992.

99.

Green, D.R., Zheng, H., and Shi, Y. Antisense oligodeoxynucleotides as probes of T lymphocyte gene function. Ann. N.Y. Acad. Sci., 660, 193-203, 1992.

100.

Cotter, T.G., Glynn, J.M., Echeverri, F. and Green, D.R. The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Res., 12, 773-780, 1992.

101.

Green, D.R. T lymphocytes. In: Lederberg, J. (ed). The Encyclopedia of Microbiology. Academic Press. 1992. pp. 243-253.

102.

Shi, Y., Bissonnette, R.P., Glynn, J.M., Guilbert, L.J., Cotter, T.G., and Green, D.R. Inhibition of activation-induced apoptosis in T cells by antisense oligodeoxynucleotides corresponding to c-myc. Science 257, 212-214, 1992.

103.

Bissonnette, R.P., Echeverri, F., Mahboubi, A., and Green, D.R. Apoptotic cell death induced by cmyc is inhibited by bcl-2. Nature, 359, 552-554, 1992.

104.

Green, D.R., and Cotter, T.G. Apoptosis in the immune system. Sem. Immunol., 4, 355-362, 1992.

105.

Green, D.R., Bissonnette, R.P., Glynn, J.M., and Shi, Y. Activation-induced apoptosis in lymphoid systems. Sem. Immunol., 4, 379-388, 1992.

106.

Richards, R., and Green, D.R. Local administration of interleukin-2 protects mice from lethal intraabdominal bacterial sepsis. In: Faist, E. (ed) The Immune Consequences of Shock, Trauma, and Sepsis, 2nd Ed., Springer-Verlag, 1993, pp 1251-1256.

107.

Green, D.R., and Webb, D.R. Saying the "S" word in public. Immunol. Today, 14, 523-525, 1993.

108.

Helgason, C.D., Shi, L., Greenberg, A.H., Shi, Y., Bromley, P., Cotter, T.G., Green, D.R., and Bleackley, R.C. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death. Exp. Cell Res. 206, 302-310, 1993.

109.

Green, D.R., and Cotter, T.G. Macromolecular synthesis, c-myc, and apoptosis. In Lavin, M., and Watters, D. (eds.) Cell Death: The Cellular and Molecular Biology of Apoptosis, Gordon Breach, New York, pp 153-166, 1993.

The

13 110.

Green, D.R. The Major Histocompatibility Complex. In: Sigal, L.H., Taffet, S.M., Gavalchin, J., and Humphrey, D.M. (eds). Immunology and Inflammation: Basic Mechanisms and Clinical Consequences McGraw-Hill, 1994, pp. 63-74.

111.

Bissonnette, R.P., Shi, Y., Mahboubi, A., Glynn, J.M., and Green, D.R. C-myc and apoptosis. In Tomei, L.D., and Cope, F.O. (eds.) Apoptosis II: The Molecular Basis of Cell Death. Cold Spring Harbor Lab. Press, Cold Spring Harbor. pp. 327-356, 1994.

112.

Green, D.R., Shi, Y., Glynn, J., Mahboubi, A., and Mogil, R.J. Myc, Fas, apoptosis, and immune tolerance. In Mihich, E., and Schimke, R.T. (eds.) Apoptosis, Plenum Press, New York. pp. 213-222, 1994.

113.

Martin, S.J., Green, D.R., and Cotter, T.G. Dicing with death: Dissecting the components of the apoptosis pathway. TIBS 19, 26-30, 1994.

114.

Green, D.R., Bissonnette, R.P., and Cotter, T.G. Apoptosis and Cancer. In DeVita, M.D., Hellman, S., and Rosenberg, S.A. (eds.) Important Advances in Oncology, 1994. pp. 37-52. Also published as: Principles and Practice of Oncology Updates, Vol. 8, 1994.

115.

Fischer, G., Kent, S.C., Joseph, L., Green, D.R., and Scott, D.W. Lymphoma models for B cell activation and tolerance. X. Anti-µ-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J. Exp. Med. 179, 221-228, 1994.

116.

Mogil, R.J., Shi, Y., Bissonnette, R.P., Bromley, P., Yamaguchi, I., and Green, D.R. The role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J. Immunol. 152, 1674-1683, 1994.

117.

McGahon, A., Bissonnette, R., Schmitt, M., Cotter, K.M., Martin, S.J., Green, D.R., and Cotter, T.G. (Shared Senior Authorship) BCR-ABL maintains resistance of chronic myelogenous leukaemia cells to apoptotic cell death. Blood, 83, 1179-1187, 1994.

118.

Green, D.R., and Scott, D.W. Activation-induced apoptosis in lymphocytes. Curr. Opinion Immunol., 6, 476-487, 1994.

119.

McGahon, A.J., Cotter, T.G., Green, D.R. The abl oncogene family and apoptosis. Cell Death Diff., 1: 77-83, 1994.

120.

Bissonnette, R.P., McGahon, A., and Green, D.R. Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas. J. Exp. Med. 180, 2413-2418, 1994.

121.

Martin, S.J., and Green, D.R. Apoptosis as a goal of cancer therapy. Curr. Opinion Oncol., 6, 616621, 1994.

122.

Yousefi, S., Green, D.R., Blaser, K., and Simon, H.U. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91, 10868-10872, 1994.

123.

Green, D.R., Mahboubi, A., Nishioka, W., Oja, S., Echeverri, F., Shi, Y., Glynn, J., Ashwell, J., and Bissonnette, R. Promotion and inhibition of activation-induced apoptosis in T cell hybridomas by oncogenes and related signals. Immunol. Rev. 142, 321-342, 1994.

124.

Martin, S.J., and Green, D.R. Apoptosis and cancer: The failure of controls on cell death and cell survival. Crit. Rev. Oncol. Hematol., 18, 137-153, 1995.

125.

Onda, T., Messier H., Bissonnette, R., Echeverri, F., Baier, G., Fotedar, A., and Green, D.R. Immunoregulatory activity of a T cell receptor α chain demonstrated by in vitro transcription and translation. Proc. Natl. Acad. Sci., 92, 3004-3008, 1995.

14 126.

Martin, S.J., and Green, D.R. Apoptosis during HIV infection: a cytopathic effect of HIV or an important host-defense mechanism against viruses in general? In: Andrieu, J.M. and Lu, W. (eds.) Cell Activation and Apoptosis in HIV Infection, Plenum Press, 1995, pp. 129-138.

127.

McGahon, A.J., Martin, S.J., Bissonnette, R.P., Mahboubi, A., Shi, Y., Mogil, R.J., and Green, D.R. The end of the (cell) line: Methods for the study of apoptosis in vitro. In Schwartz, L.M., and Osborne, B.A. (eds.) Cell Death.. Methods in Cell Biology, V. 46 Academic Press, Inc. 1995. pp153-185.

128.

Wills, C. and Green, D.R. A herd-immunity model for the maintenance of MHC polymorphism. Immunol. Rev., 143, 263-292, 1995.

129.

Brunner, T., Mogil, R.J., Mahboubi, A., LaFace, D., Yoo, N.J., Echeverri, F., Martin, S.J., Ware, C.F., and Green, D.R. Apoptosis induced by ligation of the T cell receptor on T cell hybridomas proceeds via a cell autonomous Fas (CD95)/Fas-ligand interaction. Nature 373, 441-444, 1995.

130.

Martin, S.J., O'Brien, G.A., Nishioka, W.K., McGahon, A.J., Mahboubi, A., Saido, T.C., and Green, D.R. Proteolysis of fodrin (nonerythroid spectrin) during apoptosis. J. Biol. Chem. 270, 6425-6428, 1995.

131.

Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S., Nishioka, W., Brunner, T., Baier, G., Bitterlich-Baier, G., Byrd, C., Lang, F., Kolesnick, R., Altman, A., and Green, D.R. (Shared Senior Authorship) Fas-induced apoptosis is mediated by a ceramide-initiated Ras signaling pathway. Immunity, 2, 341-351, 1995.

132.

Martin, S.J., McGahon, A.J., Nishioka, W.K., LaFace, D., Th'ng, J., Bradbury, E.M., and Green, D.R. P34cdc-2 and apoptosis. Science, 269, 106-107,1995.

133.

Onda, T., Messier, H., Bissonnette, R., Echeverri, F., Baier, G., Fotedar, A., and Green, D.R. Antigenspecific immunoregulatory activity of a T cell receptor α chain generated by expression PCR. Int. Arch. Allergy Immunol., 107, 356-358, 1995.

134.

Shi, Y., Radvanyi, L.G., Sharma, A.J., Shaw, P., Green, D.R., Miller, R.G., and Mills, G.B. CD28mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J. Immunol., 155, 1829-1837, 1995.

135.

Mogil, R.J., Radvanyi, L., Gonzalez-Quintial, R., Miller, R., Mills, G., Theofilopoulos, A.N., and Green, D.R. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. International Immunology, 7, 1451-1458, 1995.

136.

Martin, S.J., Takayama, S., McGahon, A.J., Miyashita, T., Corbeil, J., Kolesnick, R.N., Reed, J.C., and Green, D.R. Inhibition of ceramide-induced apoptosis by Bcl-2. Cell Death Diff., 2, 253-258, 1995.

137.

Martin, S.J., and Green, D.R. Protease activation in apoptosis: Death by a thousand cuts? Cell, 82,349-352, 1995

138.

Martin, S.J., Reutelingsperger, C.P.M., McGahon, A.J., Rader, J., van Schie, R.C.A.A., LaFace, D.M., and Green, D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med, 182, 1545-1556, 1995.

139.

Martin, S.J., Newmeyer, D.D., Mathias, S., Farschon, D., Wang, H.G., Reed, J., Kolesnick, R.N., Green, D.R. Cell-free reconstitution of Fas-, UV radiation-, and ceramide-induced apoptosis. EMBO J., 14, 5191-5200, 1995.

140.

Green, D.R., and Martin, S.J. The killer and the executioner: How apoptosis controls malignancy. Curr. Opin. Immunol., 7, 694-703, 1995.

15 141.

Bissonnette, R.P., Brunner, T., Lazarchik, S.B., Yoo, N.J., Boehm, M.F., Green, D.R., and Heyman, R.A. (Shared Senior Authorship) 9-cis Retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of Fas-ligand and requires RAR and RXR activation. Mol. Cell Biol., 15, 5576-5585, 1995.

142.

McGahon, A., Nishioka, W.K., Martin, S.J., Mahboubi, A., Cotter, T.G., and Green, D.R. Regulation of the Fas apoptotic cell death pathway by Abl. J. Biol. Chem., 270, 22625-22631, 1995.

143.

Griffith, T.S., Brunner, T., Fletcher, S., Green, D.R., and Ferguson, T.A. Fas/Fas-ligand-induced apoptosis as a mechanism of immune privilege. Science, 270, 1189-1192, 1995.

144.

Green, D.R., McGahon, A., and Martin, S.J. Regulation of apoptosis by oncogenes. J. Cellular Biochem., 60, 33-38, 1996.

145.

Martin, S.J., Reutelingsperger, C.P.M., and Green, D.R. Annexin V-a specific probe for the detection of phosphatidylserine exposure on the outer plasma membrane leaflet during apoptosis. In Cotter, T.G. and Martin, S.J. (eds.) Techniques in Apoptosis: A Users Guide, Portland Press, London, 1996, pp. 107-121.

146.

Martin, S.J., and Green, D.R. Cell free apoptosis. In Cotter, T.G. and Martin, S.J. (eds.) Techniques in Apoptosis: A Users Guide, Portland Press, London, 1996, pp. 121-132.

147.

Green, D.R. Overview: Apoptosis. In Herzenzerg, L.A., and Weir, D.M. (eds.) Handbook of Experimental Immunology, 5th Edition. Blackwell Science, Cambridge, 1996. pp. 123.1-123.4.

148.

Martin, S.J., and Green, D.R. Morphological features of apoptosis. In Herzenzerg, L.A., and Weir, D.M. (eds.) Handbook of Experimental Immunology, 5th Edition. Blackwell Science, Cambridge, 1996. pp. 124.1-124.5.

149.

Onda, T., La Face, D. Baier, G., Brunner, T., Honma, N., Mikayama, T., Altman, A., and Green, D.R. A phage display system for binding and selection of direct antigen-binding T cell receptor molecules. Molecular Immunology, 32, 1387-1397, 1995.

150.

Martin, S.J., Amarante-Mendes, G.P., Shi, L., Chuang, T.H., Casiano, C.A., Fitzgerald, P., Tan, E.M., Bokoch, G.M., Greenberg, A.H., and Green, D.R. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/ced-3-family protease, CPP32, via a novel two-step mechanism. EMBO J., 15, 2407-2416, 1996.

151.

Skowronski, E.W., Kolesnick, R.N., and Green, D.R. Fas-mediated apoptosis and sphingomyelinase signal transduction: The role of ceramide as a second messenger for apoptosis. Cell Death Diff., 3, 171-176, 1996.

152.

Brunner, T., Yoo, N.J., LaFace, D., Ware, C.F., and Green, D.R. Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol., 8, 1017-1026, 1996.

153.

Brunner, T., Yoo, N.J., Griffith, T.S., Ferguson, T.A., and Green, D.R. Regulation of CD95 expression: a key element in immune regulation? Behr. Inst. Mitt. 97, 161-174, 1996.

154.

Santana, P., Pena, L.A., Haimovitz-Friedman, A., Martin, S., Green, D., McLaughlin, M., CordonCardo, C., Schuchman, E.H., Fuks, Z., and Kolesnick, R. Acid sphingomyelinase deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86, 189-200, 1996.

155.

Casiano, C.A., Martin, S.J., Green, D.R., and Tan, E.M. Cleavage of a subset of nuclear autoantigens associated with different functions during CD95 (Fas/APO-1)-mediated T cell apoptosis. J. Exp. Med., 182, 765-770, 1996.

16 156.

Martin, S.J., Amarante-Mendes, G.P., Green, D.R. Cytotoxic cell killing enters the ICE age. In, Gupta, S., (ed) Mechanisms of Lymphocyte Activation and Immune Regulation VI: Cell Cycle and Programmed Cell Death in the Immune System. Adv. Exp. Med. Biol ., 406, 29-37, 1996.

157.

Griffith, T.S., Yu, X., Herndon, J.M., Green, D.R., and Ferguson, T.A. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity, 5, 7-17, 1996.

158.

Meisenholder, G.W., Martin, S.J., Green, D.R., Nordberg, J., Babior, B.M., and Gottlieb, R.A. Events in apoptosis, Acidification is downstream of protease activation and Bcl-2 protection. J. Biol. Chem. 271, 16260-16267, 1996.

159.

Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., and Verma, I.M. NF-κB activation by TNFα suppresses signals for apoptosis. Science 274, 787-789, 1996.

160.

Martin, S.J., Finucane, D.M., Amarante-Mendes, G.P., O'Brien, G.A., and Green, D.R. Phosphatidylserine externalization during CD95-induced apoptosis of both cells and cytoplasts requires ICE/CED-3 protease activity. J. Biol. Chem., 271, 28753-28756, 1996.

161.

Green, D.R., and Martin, S.J. The ICE/Ced-3-family proteases as the apoptotic executioner. Cell Death Diff. 3, 339-340, 1996.

162.

McGahon, A.J., Brown, D.G., Martin, S.J., Amarante-Mendes, G., Cotter, T.G., Cohen, G.M., Green, D.R. Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis. Characterization of the apoptotic death. Cell Death Diff., 4, 95-104, 1997.

163.

Woodle, E.S., Smith, D.M., Bluestone, J.A., Kirkman, W.M., Green, D.R., and Skowronski, E.W. Anti-human class I MHC antibodies induce apoptosis by a pathway which is distinct from the Fas antigen-mediated pathway. J. Immunol., 158, 2156-2164, 1997.

164.

Tan, X., Martin, S.J., Green, D.R., and Wang, J.Y.J. Degradation of RB at a consensus Ice/Ced-3 cleavage site during CD95-, TNF- and cisplatin-induced cell death. J. Biol. Chem., 272, 9613-9616, 1997.

165.

Kluck, R.M., Bossy-Wetzel, E., Green, D.R., and Newmeyer, D.D. (Shared Senior Authorship) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science, 275, 1132-1136, 1997.

166.

Niehans, G.A., Brunner, T., Frizzelle, S.P., Liston, J.C., Salerno, C.T., Knapp, D.J., Green, D.R., and Kratzke, R.A. Human lung carcinomas express Fas ligand. Cancer Research, 57, 1007-1012, 1997.

167.

Zhang, X., Brunner, T., Carter, L., Dutton, R.W., Sato, T., Reed, J., Green, D.R., and Swain, S.L. Unequal death in Th1 and Th2 effectors: Th1 but not Th2 effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med., 185, 1837-1849, 1997.

168.

Scott, D.W., Brunner, T., Donjerkovic´, D., Ezhevsky, S., Grdina, T., Green, D., Shi Y., and Yao, X.R. Murder and suicide: A tale of T and B cell apoptosis. In: Shi, Y-B., Shi, Y., Scott, D., and Xu, Y. (eds.), Current Advances in Programmed Cell Death, Plenum Publishing Corp., New York, 1997, pp.91-104.

169.

Green, D.R., Tietz, B., Ferguson, T.A., and Brunner, T. Taking out the immune response: The roles of Fas-ligand (CD95L) in immune regulation. In: Shi, Y-B., Shi, Y., Scott, D., and Xu, Y. (eds.), Current Advances in Programmed Cell Death, Plenum Publishing Corp., New York, 1997, pp. 147158.

170.

Green, D.R., and Ware, C.F. Fas-ligand: Privilege and peril. Proc. Natl. Acad. Sci. USA, 94, 59865990, 1997.

17 171.

Amarante-Mendes, G.P., Jascur, T., Nishioka, W.K., Mustelin, T., and Green, D.R. Bcr-Ablmediated resistance to apoptosis is independent of PI3-kinase activity. Cell Death Diff., 4, 548-555, 1997.

172.

Kluck, R.M., Martin, S.J., Hoffman, B.M., Zhou, J.S., Green, D.R., and Newmeyer, D.D. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J.,16, 4639-4649, 1997.

173.

Ellerby, H.M., Martin, S.J., Ellerby, L.M., Naiem, S.S., Rabizadeh, S., Salveson, G.S., Casiano, C.A., Cashman, N.R., Green, D.R., and Bredesen, D.E. Establishment of a cell-free system of neuronal apoptosis: Comparison of pre-mitochondrial, mitochondrial, and post-mitochondrial phases. J. Neurosci., 17, 6165-6178, 1997.

174.

Ayyavoo, V., Mahboubi, A., Williams, W.V., Mahalingam, S., Sagar, K., Green, D.R., and Weiner, W.B. HIV-1 Vpr suppresses immune activation and apoptosis through regulation with NF-kB. Nature Med., 3, 1117-1123, 1997.

175.

Firestein, G.S., Echeverri, F., Yeo, M., Zvaifler, N.J., and Green, D.R. Somatic mutations in the p53 gene in rheumatoid arthritis synovium. Proc. Natl. Acad. Sci. USA, 94, 10895-10900, 1997.

176.

Green, D.R. (Commentary) A myc-induced apoptosis pathway surfaces. Science 278, 1246-1247, 1997.

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Amarante-Mendes, G.P., McGahon, A.J., Nishioka, W.K., Afar, D.E.H., Witte, O.N., and Green, D.R. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up regulation of Bcl-xL. Oncogene 16, 1383-1390, 1998.

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Lin, T., Brunner, T., Tietz, B., Madsen, J., Bonfoco, E., Reaves, M., Huflejet, M., and Green, D.R. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes: Participation in intestinal graftversus-host disease. J. Clin. Invest., 101, 570-577, 1998.

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Harwood, F.G., Kasibhatla, S., Petak, I., Green, D.R., and Houghton, J.A. (Shared Senior Authorship) Regulation of FasL by NF-kB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. J. Biol. Chem., 275, 10023-10029, 2000.

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Melino, G., Bernassola, F., Catani, M.V., Rossi, A., and Green, D.R. Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation. Cancer Res., 60, 2377-2383, 2000.

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Nakamura, K., Bossy-Wetzel, E., Burns, K., Fadel, M., Lozyk, M., Goping, I.S., Opas, M., Bleackley, R.C., Green, D.R., and Michalak, M. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J. Cell Biol., 150, 731-740, 2000.

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Martinou, J.C. and Green, D.R. Breaking the mitochondrial barrier. Nature Rev. Mol. Cell Biol., 2, 63-67, 2001.

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Wolf, B.B., Sculer, M., Li, W., Eggers-Sedlet, B., Lee, W., Tailor, P., Fitzgerald, P., Mills, G.B., and Green, D.R. Ovarian cancer cell-line cytosols resist cytochrome c-dependent caspase activation due to diminished or absent Apaf-1 activity. J. Biol. Chem., 276, 34244-34251, 2001.

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Wasem, C., Frutschi, C., Arnold, D., Vallan, C., Lin, T., Green, D.R., Mueller, C., Brunner, T. Accumulation and Activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J Immunol. 167, 2936-2941, 2001.

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Kuwabara, I., Kuwabara, Y., Yang, R.Y., Schuler, M., Green, D.R., Zuraw, B.L., Hsu, DK, and Liu F.T. Galectin-7 (PIG1:p53-induced gene 1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem., 277, 3487-3497, 2002.

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Ferguson, T.A., Choi, J., and Green, D.R. Armed response: how dying cells influence T-cell functions. Immunol Rev 241, 77-88, 2011. PMID: 21488891

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Spierings, D.C., McGoldrick, D., Hamilton-Easton, A.M., Neale, G., Murchison, E.P., Hannon, G.J., Green, D.R., and Withoff, S. Ordered progression of stage specific miRNA profiles in the mouse B2 B cell lineage. Blood, 117, 5340-5349, 2011. PMID: 21403133

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Yeretssian, G., Correa, R.G., Doiron, K., Fitzgerald, P., Dillon, C.P., Green, D.R., Reed, J.C., and Saleh, M. Non-apoptotic role of BID in inflammation and innate immunity. Nature, 474, 96-99, 2011.

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Gawriluk, T.R., Hale, A.N., Flaws, J.A., Dillon, C.P., Green, D.R., Rucker, E.B. Autophagy is a cell survival program for female germ cells in the murine ovary. Reproduction. 141, 759-765, 2011.

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Wolkers, M.C., Bensinger, S.J., Green, D.R., Schoenberger, S.P., Janssen, E.M. Interleukin-2 rescues helpless effector CD8(+) T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett. 139, 25-32, 2011.

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Parsons, M.J., Green, D.R.. Death receptors and mitochondria: Life depends on the liver. Hepatology. 54, 13-15, 2011.

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Shi, L.Z., Wang, R., Green, D.R., and Chi, H. (shaired senior authorship) HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med., 208, 1367-1376, 2011.

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Bedford,, D.C., Kasper, L.H., Wang, R., Chang, Y., Green, D.R., and Brindle, P.K. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metabol., 14, 219-230, 2011.

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Green, D.R., Galluzzi, L., and Kroemer, G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science, 333, 1109-1112, 2011.

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Charvet, C., Wissler, M., Brauns-Schubert, P., Wang, S.J., Tang, Y., Sigloch, F.C., Mellert, H., Brandenburg, M., Lindner, S.E., Breit, B., Green, D.R., McMahon, S.B., Borner, C., Gu, W., Maurer, U. Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell. 42, 584-596, 2011.

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Yang, K., Neale, G., Green, D.R., He, W., and Chi, H. The tumor suppressor Tsc1 enforces quiescence of native T cells to promote immune homeostasis and function. Nature Immunol., 12, 888897, 2011.

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Ippagunta, S.K., Malireddi, R.K., Shaw, P.J., Neale, G.A., Walle, L.V., Green, D.R., Fukui, Y., Lamkanfi, M., and Kanneganti, T.D. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nature Immunol., 12, 1010-1016, 2011.

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Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C., Fitzgerald, P., Hengartner, M.O., and Green, D.R. Microtubule-associated protein light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc. Natl. Acad. Sci. USA, 108, 17396-17401, 2011.

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Llambi, F., Moldoveanu, T., Tait, S.W.G., Bouchier-Hayes, L., Temirov, J., McCormick, L.L., Dillon, C.P., and Green, D.R. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol. Cell, 44, 517-531, 2011.

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O’Donnell, M.A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D.R., and Ting, A.T. Caspase-8 inhibits programmed necrosis by processing CYLD. Nature Cell Biol., 13, 1437-1442, 2011.

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Szymczak-Workman, A.L., Delgoffe, G.M., Green, D.R., and Vignali, D.A.A. Cutting edge: Regulatory T cells do not mediate suppression via programmed cell death pathways. J. Immunol., 187, 4416-4420, 2011.

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Weinlich, R., Dillon, C.P., and Green, D.R. Ripped to death. Trends Cell Biol., 21, 630-637, 2011.

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Oberst, A., and Green, D.R. It cuts both ways: Reconciling the dual roles of caspase-8 in cell death and survival. Nature Rev. Mol. Cell Biol., 12, 757-763, 2011.

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Green, D.R., Oberst, A., Dillon, C.P., Weinlich, R., and Salveson, G.S. RIPK-dependent necrosis and its regulation by caspases: A mystery in five acts. Mol Cell, 44, 9-16, 2011.

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Anand, P.K., Tait, S.W., Lamkanfi, M., Amer, A.O., Nunez, G., Green, D.R., and Kanneganti, T.D. 2011. TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via ERK activation. J Biol Chem, 286, 42981-42991, 2011.

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Garrison, S.P., Phillips, D.C., Jeffers, J.R., Chipuk, J.E., Parsons, M.J., Rehg, J.E., Opferman, J.T., Green, D.R., and Zambetti, G.P. 2011. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ, 19, 642-649, 2012.

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Wang, R., Dillon, C.P., Shi, L.Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L.L., Fitzgerald, P., Chi, H., Munger, J., and Green, D.R. Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity, 35, 871-881, 2011.

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Green, D.R. The end and after: How dying cells impact the living organism. Immunity, 35, 441-444, 2011.

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Green, D.R. Immunology: A heavyweight knocked out. Nature 479, 48-50, 2011.

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Green, D.R. and Van Houten, B. Cell snapshot: Mitochondrial quality control. Cell, 147, 950, 2011.

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Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., and Schulman, B.A. Atg8 transfer from Atg7 to Atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway. Mol Cell. 44, 451-461, 2011.

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Zaki, M.H., Vogel, P., Malireddi, R.K., Body-Malapel, M., Anand, P.K., Bertin, J., Green, D.R., Lamkanfi, M., and Kanneganti, T.D. The NOD-Like-2 receptor, TLR12, attenuates colon inflammation and tumorigenesis. Cancer Cell, 20, 649-660, 2011.

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Wolkers, M.C., Gerlach, C., Arens, R., Janssen, E,M., Fitzgerald, P., Schumacher, T.N., Medema, J.P., Green, D.R., and Schoenberger, S.P. (Shared senior authorship) Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood, 119, 798-804, 2011.

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Bouchier-Hayes, L., and Green, D.R. Caspase-2: The orphan caspase. Cell Death Diff., 19, 51-57, 2012.

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Chipuk, J.E., McStay, G.P., Bharti, A., Kuwana, T., Schafer, B., Siskind, L.J., Obeid, L.M., and Green, D.R. Sphingolipid metabolism cooperates with pro-apoptotic BAK and BAX to promote mitochondrial outer membrane permeabilization and apoptosis. Cell, 148, 988-1000, 2012.

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Valentin-Vega, Y.A., MacLean, K.H., Tait-Mulder-J., Milasta, S., Steeves, M., Dorsey, F.C., Cleveland, J.L., Green, D.R., and Kastan, M.B. Mitochondrial dysfunction in Ataxia Telangiectasia. Blood, 119, 1490-1500, 2012.

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Linkermann, A., Bräsen, J.H., De Zen, F., Weinlich, R., Schwendener, R.A., Green, D.R., Kunzendorf, U., and Krautwald, S. Dichotomy between RIP1- and RIP3-mediated necroptosis in Tumor Necrosis Factor α-induced shock. Mol Med. 18, 577-586, 2012.

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Wang, X., Szymczak-Workman, A.L., Gravano, D.M., Workman, C.J., Green, D.R., and Vignali, D.A. Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis. Cell Death Dis., 3, e270, 2012.

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Bender, C.E., Fitzgerald, P., Tait, S.W., Llambi, F., McStay, G.P., Tupper, D.O., Pellettieri, J., Alvarado, A.S., Salvesen, G.S., and Green, D.R. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A., 109, 4904-4909, 2012.

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Tait, S.W., and Green, D.R. Mitochondria and cell signaling. J Cell Sci. 125, 807-815, 2012.

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Perciavalle, R.M., Stewart, D.P., Koss, B., Lynch, J., Milasta, S., Bathina, M., Temirov, J., Cleland, M.M., Pelletier, S., Schuetz, J.D., Youle, R.J., Green, D.R., Opferman, J.T. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples fusion to respiration. Nat Cell Biol. 14, 575-583, 2012.

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Imre, G., Heering, J., Takeda, A.N., Husmann, M., Thiede, B., Zu Heringdorf, D.M., Green, D.R., van der Goot, F.G., Sinha, B., Dötsch, V., and Rajalingam, K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J., 31, 2615-2628, 2012.

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Wang, R., and Green, D.R. The immune diet: Meeting the energetic demands of lymphocyte activation. F1000 Biol Reports, 4,9, 2012.

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Dillon, C.P., Oberst, A., Weinlich, R., Janke, L.J., Kang, T.B., Ben Moshe, T., Mak, T.W., Wallach, D., and Green, D.R. Survival function of the FADD-caspase-8-cFLIPL complex. Cell Reports, 1, 401407, 2012.

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Sano, R., Hou, Y.C., Hedvat, M., Correa, R.G., Shu, C.W., Krajewska, M., Diaz, P.W., Tamble, C.M., Quarato, G., Gottlieb, R.A., Yamaguchi, M., Nizet, V., Dahl, R., Thomas, D.D., Tait, S.W., Green, D.R., Fisher, P.B., Matsuzawa, S., and Reed, J.C. Endoplasmic reticulum protein BI-1 regulates Ca2+mediated bioenergetics to promote autophagy. Genes Dev., 26, 1041-1054, 2012.

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Wang, R., and Green, D.R. Metabolic reprogramming and metabolic dependency in T cells. Immunol. Rev. 249, 14-26, 2012.

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Wang, R. and Green, D.R. Metabolic checkpoints in activated T cells. Nature Immunol., 13, 907915, 2012.

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Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D.R., Tessarollo, L., Casellas, R., Zhao, K., and Levens, D. Myc is a universal amplifier of gene expression. Cell, 151, 6879, 2012.

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Green, D.R. and Victor, B. The pantheon of the fallen: Why are there so many forms of cell death? Trends Cell Biol., 22, 555-556, 2012.

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Malatesta, M., Peschiaroli, A., Memmi, E.M., Zhang, J., Antonov, A., Green, D.R., Barlev, N.A., Garabadgiu, A.V., Zhou, P., Melino, G., Bernassola,, F. The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene, advanced online publication.

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Henault, J., Martinez, J., Riggs, J.M., Tian, J., Mehta, P., Clarke, L., Latz, E., Brinkmann, M.M., Iwasaki, A., Coyle, A.J., Kolbeck, R., Green, D.R., and Sanjuan, M.A. (shared senior authorship). LC3-associated phagocytosis mediates IFN-α secretion in response to DNA-immune complexes. Immunity, 37, 986-997, 2012. PMCID: PMC3786711

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Bossaller, L., Chiang, P.I., Schmidt-Lauber, C., Ganesan, S., Kaiser, W.J., Rathinam, V.A., Mocarski, E.S., Subramanian, D., Green, D.R., Silverman, N., Fitzgerald, K.A., Marshak-Rothstein, A., and Latz, E. Cutting Edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in a RIP3-independent manner. J Immunol., 189, 5508-5512, 2012.

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Follis, A.V., Chipuk, J. E., Fisher, J. C., Yun, M. K., Grace, C. R., Nourse, A., Baran, K., Ou, L., Min, L., White, S. W., Green, D. R., and Kriwacki, R. W. (shared senior authorship). PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat. Chem. Biol., 9, 163-168, 2013.

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Green, D.R., and Walczak, H. Apoptosis therapy: Driving cancer cells down the road to ruin? Nat. Med., 19, 131-133, 2013

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Lindner, A.U., Concannon, C.G., Boukes, G.J., Cannon, M.D., Llambi, F., Ryan, D., Boland, K., Kehoe, J., McNamara, D.A., Murray, F., Kay, E.W., Hector, S., Green, D.R., Huber, H.J., and Prehn J.H. Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy. Cancer Res. 73, 519-528, 2013.

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Verbist, K.C,, Wang. R,,and Green, D.R. T cell metabolism and the immune response. Semin Immunol. 24, 399-404, 2012.

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Moldoveanu, T., Grace, C.R., Llambi, F., Nourse, A., Fitzgerald, P., Gehring, K., Kriwacki, R.W., and Green, D.R. BID-induced structural changes in BAK promote apoptosis, Nature Struct. Mol. Biol., 20, 589-597, 2013.

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Lupfer, C., Thomas, P.G., Anand, P.K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., Xavier, R.J., Green, D.R., Lamkanfi, M., Dinarello, C.A., Doherty, P.C., Kanneganti, T.D. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol. 14, 480-488, 2013.

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Parsons, M.J., McCormick, L., Janke, L., Howard, A., Bouchier-Hayes, L., Green, D.R. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 20, 1174-1182, 2013.

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Kim, J.Y., Zhao, H., Martinez, J., Doggett, T.A., Kolesnikov, A.V., Tang, P.H., Ablonczy, Z., Chan, C.C., Zhou, Z., Green, D.R., and Ferguson, T.A. (Shared senior authorship). Non-canonical autophagy promotes the visual cycle. Cell, 154, 365-376, 2013.

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Martinez, J., Verbist, K., Wang, R., Green, D.R. The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metab., 17, 895-900, 2013.

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Green, D.R., and Rathmell, J. Sweet nothings: sensing of sugar metabolites controls T cell function. Cell Metab. 18, 7-8, 2013

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Linkermann, A., Bräsen, J.H,, Darding, M., Jin, M.K., Sanz, A.B., Heller, J.O., De Zen, F., Weinlich, R., Ortiz, A., Walczak, H., Weinberg, J.M., Green, D.R., Kunzendorf, U., and Krautwald. S. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A, 110, 12024-12029, 2013.

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Green, D.R. Pseudokiller, Qu’est que c’est? Immunity, 39, 421-422, 2013.

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Weinlich, R., Oberst, A., Dillon, C.P., Janke, L.J., Milasta, S., Lukens, J.R., Diego A. Rodriguez, D.A., Prajwal Gurung, P., Savage, C., Kanneganti, T.D., Green, D.R. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Reports, 5, 340-348, 2013.

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McCoy, F., Darbandi, R., Lee, H.C., Bharatham, K., Moldoveanu, T., Royappa, G., Dodd, K., Lin, W., Chen, S.I,. Tangallapally, R.P., Kurokawa, M., Lee, R.E., Shelat, A., Chen. T., Green, D.R., Harris, R.A., Lin, S.H., Fissore, R.A., Colbran, R.J., and Nutt, L.K. Metabolic Activation of CaMKII by Coenzyme A. Mol Cell. 52, 325-339, 2013

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Tait, S.W.T., Oberst, A., Quarato, G., Milasta, S., Haller, M., Wang, R., Karvela, M., Ichim, G., Yatim, N., Albert, M.L., Kidd, G., Wakefield, R., Frase, S. Krautwald, S., Linkermann, A., and Green, D.R. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Reports, 5, 878-885, 2013.

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Tait, S.W.G., and Green, D.R. Mitochondrial regulation of cell death. In: Baehrecke, E.H., Green, D.R., Kornbluth, S., and Salvesen, G.S. (editors) Cell Survival and Cell Death. Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 2013, pp. 119-133.

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Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J.L., Soares, M.P., Gama-Carvalho, M., Martinez, J., Zhang, Q., Döring, G., Grompe, M., Simas, J.P., Huber, T.B., Baltimore, D., Gupta, V., Green, D.R., Ferreira, J.A., and Moita, L.F. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity, 39, 874-884. 2013

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Liu, Y., Shoji-Kawata, S., Sumpter, R.M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K.A., Green, D.R., Xavier, R.J., Shaw, S.Y., Clarke, P.G., Puyal, J., Levine, B. Autosis is a Na+,K+ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A. 110, 20364-20371, 2013.

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Ferguson, T.A., and Green, D.R. Autophagy and phagocytosis converge for better vision. Autophagy, 10, 165-167. 2014.

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Gilbertson, R., Parker, M., Mohankumar, K., Punchihewa, C., Weinlich, R., Dalton, J., Lee, R., Tatevossian, R., Phoenix, T., Thiruvenkatam, R., Lee, Y., White, E., Tang, B., Orisme, W., Gupta, K., Rusch, M., Chen, X., Nagahawhatte, P. Hedlund, E., Finkelstein, D.m Wu, G., Shurtleff, S., Easton, J., Boggs, K., Yergeau, D., Vadodaria, B., Mulder, H., Becksfort, J., Gupta, P., Huether, R., Ma, J., Song, G., Ding, L., Lu, C., Ochoa, K., Zhao, D., Fulton, R., Fulton, L., Mardis, E., Wilson, R., Downing, J., Green, D.R. Zhang, J., Ellison, D., Li, Y., Gajjar, A., Merchant, T., Boop, F. and Smith, A. C11orf95RELA fusions drive oncogenic NF-κB signaling in ependymoma. Nature, 506, 451-455, 2014.

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Linkerman, A., and Green, D.R. Necroptosis. N. Eng. J. Med. 370, 455-465, 2014.

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Moldoveanu, T., Follis, A.V., Kriwacki, R., and Green, D.R. Many players in Bcl-2 family affairs. Trends Biochem. Sci., Trends Biochem Sci. 39, 101-111, 2014.

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Shenderov, K., Riteau, N., Yip, R., Mayer-Barber, K.D., Oland, S., Hieny, S., Fitzgerald, P., Oberst, A., Dillon, C.P., Green, D.R., Cerundolo, V., Sher, A. Cutting Edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a Caspase-8and TRIF-dependent pathway. J Immunol., 192, 2029-2033, 2014.

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Gurung, P., Anand, P.K., Malireddi, R.K., Vande Walle, L., Van Opdenbosch, N., Dillon, C.P., Weinlich, R., Green, D.R., Lamkanfi, M., Kanneganti, T.D. FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol. 192, 1836-1846, 2014.

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Green, D.R., and Levine, B. To be or not to be? Selective autophagy and cell death govern cell fate. Cell, 157, 65-75, 2014.

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Newton, K., Hildebrand, J.M., Shen, Z., Rodriguez, D., Alvarez-Diaz, S., Petersen, S., Shah, S., Dugger, D.L., Huang, C., Auwerx, J., Vandenabeele, P., Green, D.R., Ashkenazi, A., Dixit, V.M., Kaiser, W.J., Strasser A,. Degterev, A., and Silke, J. Is SIRT2 required for necroptosis? Nature. 506:E4-6, 2014.

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Thorburn, J., Andrysik, Z., Staskiewicz, L., Gump, J., Maycotte, P., Oberst, A., Green, D.R., Espinosa, J.M., and Thorburn, A. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Rep. 7, 45-52, 2014.

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Caro-Maldonado, A., Wang, R., Nichols, A.G., Kuraoka, M., Milasta, S., Sun, L.D., Gavin, A.L., Abel, E.D., Kelsoe, G., Green, D.R., and Rathmell, J.C. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 192, 3626-3636, 2014.

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Philip, N.H., Dillon, C.P., Snyder, A.G., Fitzgerald, P., Wynosky-Dolfi, M.A., Zwack, E.E., Hu, B., Fitzgerald, L., Mauldin, E.A., Copenhaver, A.M., Shin, S., Wei, L., Parker, M., Zhang, J., Oberst, A., Green, D,R., and Brodsky, I.E.. Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling. Proc Natl Acad Sci U S A. 111, 7385-7390, 2014.

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Follis, A.V., Llambi, F., Ou, L., Baran, K., Green, D.R., and Kriwacki, R.W. (Shared senior authorship) The DNA binding domain is a promiscuous interaction hub that mediates the nuclear and cytoplasmic functions of p53. Nature Struct. Mol. Biol., 21, 735-743, 2014.

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Tait, S.W., Ichim, G., and Green, D.R. Die another way—non-apoptotic mechanisms of cell death. J. Cell Sci., 127, 2135-2144, 2014.

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Qian, W., Wang, J., Roginskaya, V., McDermott, L.A., Edwards, R.P., Stolz, D.B., Llambi, F., Green, D.R., Houten, B.V. Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget. 2014 May 4. [Epub ahead of print]

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Orozco, S., Yatim, N., Werner, M.R., Tran, H., Gunja, S.Y., Tait, S.W., Albert, M.L., Green, D.R., Oberst ,A. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ. 2014. [Epub ahead of print]

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Ganesan, S., Rathinam, V.A., Bossaller, L., Army, K., Kaiser, W.J., Mocarski, E.S., Dillon, C.P., Green, D.R., Mayadas, T.N., Levitz, S.M., Hise, A.G., Silverman, N., Fitzgerald, K.A. Caspase-8 modulates Dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. J Immunol., 193, 2519-2530, 2014.

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Books and Volumes 1.

Kaplan, J.G., Green, D.R. and Bleakley, R.C. (editors). Cellular Basis of Immune Modulation, Progress in Leukocyte Biology Vol. 9, New York:Alan R. Liss, 1989.

2.

Faist, E., Ninnemann, J., and Green, D. (editors). The Immune Consequences of Shock, Trauma, and Sepsis, Springer-Verlag, Berlin, 1989.

3.

Golub, E.S., and Green, D.R. Immunology: A Synthesis, 2nd edition. Sinauer Press, Sunderland, 1991.

4.

Green, D.R. (editor) Apoptosis in the Immune System. Sem. Immunol. V. 4. Saunders Scientific Pub., 1992.

5.

Green, D.R. (section editor) Section 21, Apoptosis. In L.A. Herzenberg, D.M. Weir, L.A. Herzenberg, and C. Blackwell (eds). Handbook of Experimental Immunology, 5th Edition, Vol. 3. Blackwell Science, Cambridge, 1996.

6.

Henderson, C.E., Green, D., Mariani, J., and Christen, Y. (editors). Neuronal Death by Accident or by Design. Springer-Verlag, Berlin. 2001.

7.

Green, D.R. (guest editor) Apoptotic Pathways in the Immune System. Immunol. Rev. Vol. 193. Blackwell Munskgard. 2003.

8.

Green, D.R. (guest editor) Apoptosis in the Development and Function of the Immune System. Semin. Immunol. V. 15, pp. 121-199. 2003.

9.

Green, D.R., and Kroemer, G. (guest editors) Pharmacologic Manipulation of Cell Death. J. Clin. Invest. 115, 2610-2688, 2005.

10.

Green, D.R., and Reed, J.C. (editors) Apoptosis: Physiology and Pathology of Cell Death, Cambridge University Press, Cambridge, 2011.

11.

Green, D.R. Means to an End. Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2011.

12.

Green, D.R. (guest editor) Immunometabolism. Sem. Immunol., V. 24, 2012.

13.

Baehrecke, E.H., Green, D.R., Kornbluth, S., and Salvesen, G.S. (editors) Cell Survival and Cell Death. Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 2013.

Other (Book Reviews, letters, editorials) 1.

Green, D.R. Review of Developmental Biology: A Comprehensive Synthesis. Quart. Rev. Biol., 65, 356-357, 1990.

2.

Green, D.R. Cell death and immunity. (Review of C.A. Gregory, ed. Apoptosis and the Immune Response). Science, 269, 861-862, 1995.

3.

Green, D.R., and Beere, H.M. Apoptosis (poster). Immunol. Today, December, 1998.

4.

Firestein, G.S., Zvaifler, N.J., and Green, D.R.. p53 mutations in rheumatoid arthritis; Response to Kawai, et al., Arthritis Rheum, 43:469-70, 2000.

38 5.

Melino G, Knight RA and Green DR. Publications in Cell Death: the golden age. Cell Death Differ, 8, 1-5, 2001.

6.

Green, D.R. and Melino, G. ICE heats up. Cell Death Diff., 8, 549-550, 2001.

7.

Ferguson, T.A., and Green, D.R. Fas-ligand and immune privilege: The eyes have it. Cell Death Differ. 8, 771-772, 2001.

8.

Green, D.R. Apoptosis and elephants (Review of M.D. Jacobson and N. McCarthy, ed. Apoptosis, the molecular biology of programmed cell death). Trends Cell Biol., 12, 539-540, 2002. Also published in TIBS, 27, 590-592, 2002.

9.

Beere, H. and Green, D.R. Apoptosis and Disease (Poster). TIBS, Trends Cell Biol., March 2003; Trends Immunol., Drug Disc. Today, April 2003.

10.

Green DR, Knight RA, Melino G, Finazzi-Agro' A, and Orrenius S. Ten years of publication in cell death. Cell Death Differ., 11,2-3, 2004.

11.

Green, D.R. Early work on the role of mitochondria, an interview with Doug Green. Cell Death Differ., 11, Suppl 2:S119-S121, 2004.

12.

Green, D.R., Melino, G. Apoptotic gene therapy in the interdigital web. Cell Death Differ. 12, 410, 2005

13.

Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: anti-apoptotic Bcl-2 family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_17525.

14.

Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: multidomain Bcl-2 family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18015.

15.

Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: BH3 only Bcl-2 Family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18017.

16.

Bender CE, Spierings DCJ, McStay, GP, Chipuk JE, Saleh M, Maurer U and Green DR. Mitochondrial Pathway of Apoptosis: Caspases. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18019.

17.

Green, D.R. Apoptosis in mammals. In: Apoptosis. Henry Stewart Talks. 2007

18.

Green, D.R. The mitochondrial pathway of apoptosis, In: Mitochondria. Henry Stewart Talks. 2007.

19.

Chipuk, J.E., Green, D.R. Response to Callus et al on 'Cytoplasmic p53 is not required for PUMAinduced apoptosis'. Cell Death Differ., 15, 215-216, 2008

20.

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E.S., Baehrecke, E.H., Blagosklonny, M.V., El-Deiry, W.S., Golstein, P., Green, D.R., et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16, 3-11, 2009. PMCID: PMC2744427

21.

Green, D.R. April fish. Oncogene, 28, 1569, 2009.

22.

Gulluzzi, L., et al., Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ., 16, 1093-1107, 2009.

23.

Green, D.R. Stress in biomedical research: Six impossible things. Mol. Cell, 40, 176-178, 2010.

39 24.

Green, D.R. Opinion: Success! The Scientist, Dec 21, 2010

25.

Green, D.R. Opinion: Six impossible things. The Scientist, Jan. 4, 2011

26.

Green, D.R. “Tit for tat” in cell biology. Nat. Rev. Mol. Cell Biol. 12, 73, 2011.

27.

Kroemer, G., Martinon, F., Lippens, S., Green, D.R., Knight, R., Vandenabeele, P., Piacentini, M., Nagata, S., Borner, C., Simon, H.U., Krammer, P., and Melino, G. Jurg Tschopp-1951-2011-an immortal contribution. Cell Death Differ 18, 1087-1088, 2011. PMID: 21527939

28.

Galluzzi, L., et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ., 19, 107-120, 2012.

29.

Green, D.R. Metabolism and immunity: The old and the new. Sem. Immunol., 24, 383, 2012.

30.

Bendall, L.J., and Green, DR. Autopsy of a cell. Leukemia. In press.

31.

McStay, G.P., and Green, D.R. Detection of caspase activity using antibody-based techniques. Cold Spring Harb Protoc. 2014:pdb.prot080291.

32.

McStay, G.P., and Green, D.R. Assaying caspase activity in vitro. Cold Spring Harb Protoc. 2014 :pdb.prot080283.

33.

McStay, G.P., and Green, D.R.Preparation of cytosolic extracts and activation of caspases by cytochrome c. Cold Spring Harb Protoc. 2014 :pdb.prot080275.

D.R. Green has also published over 90 essays in the “Sticky Wickets” column in the Journal of Cell Science, under the pseudonym, “The Mole.”

Patents 1.

D.R. Green and T.G. Cotter. Enhancement of apoptosis using antisense oligonucleotides. US Patent No. 5,583,034. Application Serial No. 08/200,723. Filed, Feb. 22, 1994. Issue Date, Dec. 10, 1996. (Ref. PD-2172)

2.

Firestein, G., Zvaifler, N., and Green, D.R. Methods for treating arthritis by administering an apoptosis regulator. U.S. Patent no. 6,004,942. Filed, Aug. 30, 1996; Issued, Dec. 21, 1999.

3.

Kasibhatla, S., Green, D.R., Tseng, B. Method of identifying immunsuppressive agents. Filed: Aug. 2, 2001.

4.

Wang, Y., Cai, X., Weber, E., Mills, G.B., Green, D.R., and Guan, L. Substituted alpha-hydroxyl acid caspase inhibitors and the use thereof. US Patent no., 6, 495, 522. Issue Date, Dec. 17, 2002.