Pediatr Infect Dis J, 1995; 14:935-40 0891-3668/95/$03.00/0 Copyright© 1995 by Williams & Wilkins

Vol.14, No.11 Printed in U.S.A.

Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children VIRAT SIRISANTHANA, MD AND THIRA SIRISANTHANA, MD

Disseminated infection with the fungus Penicillium marneffei is one of the most common opportunistic infection in human immunodeficiency virus (HIV) disease in northern Thailand. We report the clinical, laboratory and therapeutic features of 21 human immunodeficiency virus-infected children with disseminated P. marneffei who were prospectively followed. Significant clinical and laboratory features included generalized lymphadenopathy (90%), hepAccepted for publication July 19, 1995. From the Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Key words: Penicillium marneffei, human immunodeficiency virus infection, acquire immunodeficiency syndrome, opportunistic infection, fungal infection, children Address for reprints: Virat Sirisanthana, M.D. Section of Infectious Disease, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Fax +66-53-217144

atomegaly (90%), body temperature >38.5o C (81%), papular skin lesions with central umbilication (67%), splenomegaly (67%), failure to thrive (52%), severe anemia (hemoglobin < 60 g/liter) (43%) and thrombocytopenia (platelet count