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Material Safety Data Sheet acc. to ISO/DIS 11014 Printing date 01/21/2009 *

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1 Identification of substance · Product details · Trade name: EN³HANCE Liquid Autoradiography Enhancer · Article number: 6NE9701 · Application of the substance / the preparation Laboratory chemicals · Manufacturer/Supplier: PerkinElmer Life & Analytical Sciences B.V. Rigaweg 22 9723 TH Groningen The Netherlands P.O. Box 5205 9700 GE Groningen The Netherlands Phone: 0031 50 5445900 Fax: 0031 50 5445950 www.perkinelmer.com · Information department: Environment, Safety and Health (ESH) [email protected]

*

2 Composition/Data on components · Chemical characterization · Description: Mixture of the substances listed below with nonhazardous additions. · Dangerous components: 64-19-7 acetic acid C; R 10-35 Danger: 3.2/1A Warning: 2.6/3 110-03-2 2,5-dimethylhexane-2,5-diol Xi; R 36 Warning: 3.3/2A 75-65-0 2-methylpropan-2-ol Xn, F; R 11-20 Danger: 2.6/2 Warning: 3.1.I/4 91-57-6 2-methylnaphthalene Xn, N; R 22-51/53 Danger: 3.1.O/3 4.1.C/2 · Non-Dangerous components 92-71-7 2,5-Diphenyloxazole (PPO) · Additional information: For the wording of the listed risk phrases refer to section 16.

*

80-100%

2.5-10% 2.5-10%

2.5-10%

≤ 2.5%

3 Hazards identification · Hazard description: C Corrosive · Information pertaining to particular dangers for man and environment: The product has to be labelled due to the calculation procedure of the "General Classification guideline for preparations of the EU" in the latest valid version. R 10 Flammable. R 34 Causes burns. (Contd. on page 2) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 1)

R 52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment · Classification system: The classification was made according to the latest editions of international substances lists, and expanded upon from company and literature data. · NFPA ratings (scale 0 - 4)

3

2

Health = 3 Fire = 2 Reactivity = 0

0

· WHMIS-ratings (scale 0 - 4) HEALTH

3

FIRE

2

REACTIVITY 0

Health = 3 Fire = 2 Reactivity = 0

· GHS label elements Danger 3.2/1B - Causes severe skin burns and eye damage. Warning 2.6/3 - Flammable liquid and vapour. 4.1/3 - Harmful to aquatic life with long lasting effects. · Prevention: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash thoroughly after handling. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. · Response: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/ shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Wash contaminated clothing before reuse. In case of fire: Use for extinction: CO2, powder or water spray. · Storage: Store in a well-ventilated place. Keep cool. Store locked up. (Contd. on page 3) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 2)

· Disposal: Dispose of contents/container in accordance with local/regional/national/international regulations.

4 First aid measures · General information: Immediately remove any clothing soiled by the product. · After inhalation: In case of unconsciousness place patient stably in side position for transportation. · After skin contact: Immediately wash with water and soap and rinse thoroughly. · After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor. · After swallowing: Drink copious amounts of water and provide fresh air. Immediately call a doctor.

5 Fire fighting measures · Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. · For safety reasons unsuitable extinguishing agents: Water with full jet · Protective equipment: No special measures required.

6 Accidental release measures · Person-related safety precautions: Wear protective equipment. Keep unprotected persons away. · Measures for environmental protection: Do not allow to enter sewers/ surface or ground water. · Measures for cleaning/collecting: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Use neutralizing agent. Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. *

7 Handling and storage · Handling: · Information for safe handling: Work only in fume cabinet. Use only in well ventilated areas. · Information about protection against explosions and fires: Keep ignition sources away - Do not smoke. Protect against electrostatic charges. · Storage: · Requirements to be met by storerooms and receptacles: No special requirements. · Information about storage in one common storage facility: Not required. · Further information about storage conditions: Store receptacle in a well ventilated area. Keep receptacle tightly sealed.

8 Exposure controls and personal protection · Additional information about design of technical systems: No further data; see item 7. (Contd. on page 4) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 3)

· Components with limit values that require monitoring at the workplace: 64-19-7 acetic acid PEL 25 mg/m³, 10 ppm REL Short-term value: 37 mg/m³, 15 ppm Long-term value: 25 mg/m³, 10 ppm TLV Short-term value: 37 mg/m³, 15 ppm Long-term value: 25 mg/m³, 10 ppm 75-65-0 2-methylpropan-2-ol PEL 300 mg/m³, 100 ppm REL Short-term value: 450 mg/m³, 150 ppm Long-term value: 300 mg/m³, 100 ppm TLV 303 mg/m³, 100 ppm · Additional information: The lists that were valid during the creation were used as basis. · Personal protective equipment: · General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin. · Breathing equipment: Not required. · Protection of hands: Protective gloves The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation · Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. · Penetration time of glove material The exact break trough time has to be found out by the manufacturer of the protective gloves and has to be observed. · Eye protection: Tightly sealed goggles

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9 Physical and chemical properties · General Information Form:

Fluid (Contd. on page 5) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 4)

Color: Odor:

According to product specification Characteristic

· Change in condition Melting point/Melting range: Undetermined. Boiling point/Boiling range: Undetermined. · Flash point:

39°C (102°F)

· Auto igniting:

Product is not selfigniting.

· Danger of explosion:

Product is not explosive. However, formation of explosive air/vapor mixtures are possible.

· Explosion limits: Lower: Upper:

4.0 Vol % 17.0 Vol %

· Density at 20°C (68°F):

0.978 g/cm³

· Solubility in / Miscibility with Not miscible or difficult to mix. Water: · Solvent content: Organic solvents:

75-85 %

10 Stability and reactivity · Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. · Dangerous reactions No dangerous reactions known. · Dangerous products of decomposition: No dangerous decomposition products known.

11 Toxicological information · Acute toxicity: · LD/LC50 values that are relevant for classification: 64-19-7 acetic acid Oral LD50 3310 mg/kg (rat) · Primary irritant effect: · on the skin: Caustic effect on skin and mucous membranes. · on the eye: Strong caustic effect. · Sensitization: No sensitizing effects known. · Additional toxicological information: The product shows the following dangers according to internally approved calculation methods for preparations: Corrosive Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of esophagus and stomach. USA

(Contd. on page 6)

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 5)

12 Ecological information · General notes: Water hazard class 1 (Self-assessment): slightly hazardous for water Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system. Must not reach bodies of water or drainage ditch undiluted or unneutralized.

13 Disposal considerations · Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system. · Uncleaned packagings: · Recommendation: Disposal must be made according to official regulations.

14 Transport information · DOT regulations:

8 · Hazard class: UN2920 · Identification number: II · Packing group: · Proper shipping name (technical name): CORROSIVE LIQUID, FLAMMABLE, N.O.S. (ACETIC ACID, GLACIAL, BUTANOLS) 8+3 · Label · Land transport ADR/RID (cross-border):

· ADR/RID class: · Danger code (Kemler): · UN-Number: · Packaging group: · Description of goods:

8 (CF1) Corrosive substances 83 2920 II 2920 CORROSIVE LIQUID, FLAMMABLE, N.O.S. (ACETIC ACID, GLACIAL, BUTANOLS)

· Maritime transport IMDG:

· IMDG Class: · UN Number: · Label

8 2920 8+3 (Contd. on page 7) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 6)

· Packaging group: · EMS Number: · Marine pollutant: · Propper shipping name:

II F-E,S-C No CORROSIVE LIQUID, FLAMMABLE, N.O.S. (ACETIC ACID, GLACIAL, BUTANOLS)

· Air transport ICAO-TI and IATA-DGR:

· ICAO/IATA Class: · UN/ID Number: · Label · Packaging group: · Propper shipping name:

8 2920 8+3 II CORROSIVE LIQUID, FLAMMABLE, N.O.S. (ACETIC ACID, GLACIAL, BUTANOLS)

· UN "Model Regulation": UN2920, CORROSIVE LIQUID, FLAMMABLE, N.O.S., 8 (3), II *

15 Regulations · Sara · Section 355 (extremely hazardous substances): None of the ingredient is listed. · Section 313 (Specific toxic chemical listings): 75-65-0 2-methylpropan-2-ol · TSCA (Toxic Substances Control Act): All ingredients are listed. · Proposition 65 · Chemicals known to cause cancer: None of the ingredients is listed. · Chemicals known to cause reproductive toxicity for females: None of the ingredients is listed. · Chemicals known to cause reproductive toxicity for males: None of the ingredients is listed. · Chemicals known to cause developmental toxicity: None of the ingredients is listed. · Cancerogenity categories · EPA (Environmental Protection Agency) None of the ingredients is listed. · IARC (International Agency for Research on Cancer) None of the ingredients is listed. · NTP (National Toxicology Program) None of the ingredients is listed. (Contd. on page 8) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 7)

· TLV (Threshold Limit Value established by ACGIH) 75-65-0 2-methylpropan-2-ol

A4

· MAK (German Maximum Workplace Concentration) None of the ingredients is listed. · NIOSH-Ca (National Institute for Occupational Safety and Health) None of the ingredients is listed. · OSHA-Ca (Occupational Safety & Health Administration) None of the ingredients is listed. · Product related hazard informations: The product has been classified and marked in accordance with directives on hazardous materials. · Hazard symbols: C Corrosive

· Hazard-determining components of labelling: acetic acid · Risk phrases: 10 Flammable. 34 Causes burns. 52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment · Safety phrases: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 37/39 Wear suitable gloves and eye/face protection. · National regulations: · Technical instructions (air): Class Share in % II

79.9

· Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.

16 Other information This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. · Relevant R-phrases 10 Flammable. 11 Highly flammable. 20 Harmful by inhalation. 22 Harmful if swallowed. 35 Causes severe burns. 36 Irritating to eyes. 51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment · Department issuing MSDS: Environment, Safety and Health (ESH) · Contact: J. van der Weele (Contd. on page 9) USA

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Trade name: EN³HANCE Liquid Autoradiography Enhancer (Contd. of page 8)

· Abbreviations and acronyms: ADR: Accord européen sur le transport des marchandises Dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) RID: Reglement internationale concernent le transport des merchandises dangereuses par chemin de fer (Regulations Concerning the International Transport of Dangerous Goods by Rail) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association IATA-DGR: Dangerous Goods Regulations by the "International Air Transport Association" (IATA) ICAO: International Civil Aviation Organization ICAO-TI: Technical Instructions by the "International Civil Aviation Organization" (ICAO) GHS: Globally Harmonized System of Classification and Labelling of Chemicals ACGIH: American Conference of Governmental Industrial Hygienists NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent

· * Data compared to the previous version altered. USA