Dr. med. Wolf Müller Deputy Department of Neuropathology

Department of Neuropathology Ruprecht Karls University Im Neuenheimer Feld 220 69120 Heidelberg +49-6221- 56 - 5610 (phone) [email protected]

Scientific Vita 1998 2000 1998 - 2002 2003 - 2005 Sep. 2006 Sep. 2006 Oct. 2006 Since 2007 2011

MD degree, University of Hamburg, Germany Medical Thesis (Promotion), University of Hamburg, Germany Resident Neuropathology, Charité, Berlin, Germany Research Fellow, Harvard, USA Board Certification Neuropathology, Charité, Berlin, Germany Consultant Neuropathology, Charité, Berlin, Germany Interim Head of Neuropathology Department, University of Heidelberg, Germany Deputy Neuropathology, University of Heidelberg, Germany Postdoctoral Lecture Qualification (Habilitation), University of Heidelberg, Germany

Research Focus Pathology of tumors of the central and peripheral nervous systems Pathology of muscle disease and diseases affecting the peripheral nerves Molecular genetics and epigenetics of tumors of the central nervous system For specific information:

Publikationen

Mueller W, Spector Y, Bocker Edmonston T, St.Cyr B, Jaeger D, Lass U, Aharonov R, Rosenwald S, Chajut A: Accurate classification of metastatic brain tumors using a novel microRNA-based test. Oncologist. 2011 Jan 27. [Epub ahead of print]

Dögel D, Mueller W, Deckert M, Lenhard T, Schmidt-Bacher A, Storch-Hagenlocher B, Biller A, Wildemann B: An unusual case of aggressive optic neuritis. Journal of the Neurological Sciences 2011 (in press)

Keil H, Mueller W, Herold-Mende C, Gebhard MM, Germann G, Engel H, Reichenberger MA: Preoperative shock wave treatment enhances ischemic tissue survival, blood flow and angiogenesis in a rat skin flap model. Int J Surg. 2011 Jan 21. [Epub ahead of print]

Reichenberger MA, Keil H, Mueller W, Herold- Mende C, Meirer R, Gebhard MM, Germann G, Engel H: Optimal Timing of Extracorporeal Shock Wave Treatment to Protect Ischemic Tissue. Annals of Plastic Surgery 2010, (in press)

Reichenberger MA, Keil H, Mueller W, Herold- Mende C, Gebhard MM, Germann G, Engel H: Comparison of extracorporeal shock- wave pretreatment to classic surgical delay in a random pattern skin flap model. Plastic and Reconstructive Surgery 2010 (in press)

Jeuken JW, Sijben A, Bleeker FE, Boots-Sprenger SH, Rijntjes J, Gijtenbeek JM, Mueller W, Wesseling P.: The Nature and Timing of Specific Copy Number Changes in the Course of Molecular Progression in Diffuse Gliomas: Further Elucidation of Their Genetic "Life Story" Brain Pathol. 2010 Sep 30. doi: 10.1111/j.1750-3639.2010.00447.x. [Epub ahead of print]

Zweckberger K, Jung CS, Mueller W, Unterberg A, Schick U: Hemangiopericytomas WHO Grade II are not benign tumors. Acta Neurochir (Wien). 2011 Feb;153(2):385-94. Epub 2010 Nov 21.

Lenhard T, Biller A, Mueller W, Metz I, Schönberger J, Wildemann B.: Immune reconstitution inflammatory syndrome after withdrawal of natalizumab? Neurology. 2010 Aug 31; 75(9):831-3.

Elias A, Siegelin M, Steinmüller A, von Deimling A, Lass U, Korn B, Mueller W: Epigenetic silencing of Death receptor 4 mediates TRAIL- resistance in gliomas. Clin Cancer Res. 2009 Sep 1;15(17):5457-65. Epub 2009 Aug 25.

Mogler C, Kohlhoff P, Penzel R, Grenacher L, Haag G, Schirmacher P, Mueller W: A Primary Malignant Ependymoma of the Abdominal Cavity: A Case Report and Review of the Literature. Virchows Archiv, 2009 Feb 24.

Mueller W, von Deimling A: Gene regulation by methylation. (Review) Recent Results Cancer Res. 2009;171:217-39.

Meyer J, Pusch S, Balss J, Capper D, Mueller W, Christians A, Hartmann C, von Deimling A.: PCR- and Restriction Endonuclease-Based Detection of IDH1 Mutations. Brain Pathol. 2009 Aug 18. [Epub ahead of print]

Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, Felsberg J, Wolter M, Mawrin C, Wick W, Weller M, Herold-Mende C, Unterberg A, Jeuken JW, Wesseling P, Reifenberger G, von Deimling A.: Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009 Oct;118(4):469-74. Epub 2009 Jun 25.

Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celike T, Martin-Villalba A: The Death Receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell. 2009 Aug 7;5(2):178-90.

Capper D, Gaiser T, Hartmann C, Habel A, Mueller W, Herold-Mende C, von Deimling A, Siegelin MD: Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit downregulation of caspase-8 by promoter methylation. Acta Neuropathol. 2009 Apr;117(4):44556. Epub 2009 Feb 12

Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, Castresana JS: RASSF1A-, BLU-, NORE1A-, PTEN- and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol. 2009 Apr;19(2):279-92.

Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A.: Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008 Dec;116(6):597-602. Epub 2008 Nov 5.

Lorente A, Mueller W, Urdangarín E, Lázcoz P, von Deimling A, Castresana JS: Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR. BMC Cancer 2008, 8:61.

Posch MG, Posch M, Geier C, Erdmann B, Mueller W, Richter A, Puppert V, Pankuweit S, Maisch B, Perrot A, Buttgereit J, Dietz R, Haverkamp W, Özcelik C: A missense variant in Desmoglein-2 predisposes to Dilated Cardiomyopathy. Mol Genet Metab. 2008 SepOct;95(1-2)

Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Vigouroux AR, HeroldMende C, Martin-Villalba A: Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell 2008 Mar;13(3):235-48

Mueller W, Nutt CL, Ehrich M, Riemenschneider MJ, von Deimling A, van den Boom D, Louis DN: Downregulation of RUNX3 and TES by hypermethylation in glioblastoma. Oncogene. 2007 Jan 25;26(4):583-93.

Mueller W, Schneider GH, Hoffmann KT, Zschenderlein R and von Deimling A: Granulomatous tissue response in germinoma, a diagnostic pitfall in endoscopic biospsy. Neuropathology 2007, 27(2):127-32

Mueller W, Lass U, Veelken J, Reuter F, von Deimling A: 45-year-old male with symptomatic mass in the frontal lobe. Brain Pathol 2006, 16:89-90, 93

Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Richardson D, Shepherd R, Small A, Solomon H, Tofts C, Varian J, West S, Widaa S, Yates A, Easton DF, Riggins G, Roy JE, Levine KK, Mueller W, Batchelor TT, Louis DN, Stratton MR, Futreal PA, Wooster R: A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 2006, 66:3987-3991

Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN: In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol 2005, 167:1379-1387

Hartmann C, Mueller W, Lass U, Kamel-Reid S, von Deimling A: Molecular genetic analysis of oligodendroglial tumors. J Neuropathol Exp Neurol 2005, 64:10-14 Mueller W, Lass U, Wellmann S, Kunitz F, von Deimling A: Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas. Acta Neuropathol (Berl) 2005, 109:314-320

Mueller W, Mizoguchi M, Silen E, D'Amore K, Nutt CL, Louis DN: Mutations of the PIK3CA gene are rare in human glioblastoma. Acta Neuropathol (Berl) 2005, 109:654-655

Hartmann C, Numann A, Mueller W, Holtkamp N, Simon M, von Deimling A: Fine mapping of chromosome 22q tumor suppressor gene candidate regions in astrocytoma. Int J Cancer 2004, 108:839-844

Posch MG, Zang C, Mueller W, Lass U, von Deimling A, Elstner E: Somatic mutations in peroxisome proliferator-activated receptor-gamma are rare events in human cancer cells. Med Sci Monit 2004, 10:BR250-254

Mueller W, Eum JH, Lass U, Paulus W, Sarkar C, Bruck W, von Deimling A: No evidence of hSNF5/INI1 point mutations in choroid plexus papilloma. Neuropathol Appl Neurobiol 2004, 30:304-307

Hartmann C, Mueller W, von Deimling A: Pathology and molecular genetics of oligodendroglial tumors. J Mol Med 2004, 82:638-655

Weber A, Wandinger KP, Mueller W, Aktas O, Wengert O, Grundstrom E, Ehrlich S, Windemuth C, Kuhlmann T, Wienker T, Bruck W, Zipp F: Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis. J Neuroimmunol 2004, 149:195-201

Hartmann C, Mueller W, Lass U, Stockhammer F, von Eckardstein K, Veelken J, Jeuken J, Wick W, von Deimling A: No preferential loss of paternal 19q alleles in oligodendroglial tumors. Ann Neurol 2003, 54:256-258

Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J, Veelken J, Schramm J, Weller M, Wiestler OD, Louis DN, von Deimling A: Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. Am J Pathol 2002, 161:313-319

Schmidt MC, Antweiler S, Urban N, Mueller W, Kuklik A, Meyer-Puttlitz B, Wiestler OD, Louis DN, Fimmers R, von Deimling A: Impact of genotype and morphology on the prognosis of glioblastoma. J Neuropathol Exp Neurol 2002, 61:321-328

Kuhlmann T, Glas M, zum Bruch C, Mueller W, Weber A, Zipp F, Bruck W: Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. J Neuroimmunol 2002, 129:154-160

Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A: Rare mutations of the DMBT1 gene in human astrocytic gliomas. Oncogene 2002, 21:5956-5959,

Schmitz U, Mueller W, Weber M, Sevenet N, Delattre O, von Deimling A: INI1 mutations in meningiomas at a potential hotspot in exon 9. Br J Cancer 2001, 84:199-201

Kroppenstedt SN, Liebig T, Mueller W, Graf KJ, Lanksch WR, Unterberg AW: Secondary abscess formation in pituitary adenoma after tooth extraction. Case report. J Neurosurg 2001, 94:335-338

Schielke E, Nolte C, Muller W, Bruck W: Sarcoidosis presenting as rapidly progressive dementia: clinical and neuropathological evaluation. J Neurol 2001, 248:522-524

Mueller W, Lass U, Herms J, Kuchelmeister K, Bergmann M, von Deimling A: Clonal analysis in glioblastoma with epithelial differentiation. Brain Pathol 2001, 11:39-43,

Muller W, Saeger W, Wellhausen L, Derwahl KM, Hamacher C, Ludecke DK: Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study. Pathol Res Pract 1999, 195:595-603