Curriculum Vitae Prof. Dr. Detlev Ganten

Professor Dr. Detlev Ganten is a specialist in pharmacology and molecular medicine and is one of the leading scientists worldwide in the field of hypertension. Professor Ganten is the founding president of the World Health Summit (since 2009). He is Chairman of the Foundation Board of the Charité Foundation (since 2005) and editor of the Journal of Molecular Medicine (since 1993). Other roles held include Chairman of the Board of Trustees of the Max Planck Institutes of Colloids and Interfaces and Molecular Plant Physiology (Potsdam-Golm) and Chairman of the Board of Trustees of the Ethnological Museum Dahlem of the Prussian Cultural Heritage Foundation. From 2004 to 2008 Professor Detlev was CEO of the Charité – Universitätsmedizin Berlin and from 1991 to 2004 Founding Director and CEO of the MaxDelbrück Center for Molecular Medicine.

Academic and professional career Professor Ganten completed agricultural training in Elmshorn in 1959 with the agricultural assistant state examination. Following his secondary education (Abitur) he studied medicine in Würzburg and Montpellier (France) from 1962 to 1964 and worked in the surgical ward of the hospital "La Mamounia" in Marrakech (Morocco). From 1966 to 1968 he continued his medical studies in Tübingen, concluding them with the medical state examination and subsequent internships in Tübingen and Emden. In 1968 Professor Ganten received his MD from Tübingen University followed by a research period (1969 to 1973) at the Clinical Research Institute in Montréal (Canada). In 1970 he received his license to practice medicine and then in 1973, obtained the degree of Doctor of Philosophy (PhD) from McGill University in Montréal. From 1973 to 1991 Professor Ganten worked for the Pharmacological Institute of the University of Heidelberg where he also qualified as a professor in 1974. In 1975 he received a professorship in Pharmacology at the Medical Faculty of Heidelberg University. In 1978 he became specialist in Pharmacology and Clinical Pharmacology. On January 1, 1992, Professor Ganten was appointed Founding Director of the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch. His task was to transform the central institutions for cardiovascular research, cancer research and molecular biology of the Academy of Sciences of the GDR into a new national center for health research of the Helmholtz Association of German Research Centres. Around the same time (1993) he was offered the chair for Clinical Pharmacology at the Free University Berlin. In this period he promoted, in particular, clinical translational research from basic research to clinical application. For this purpose he intensified the cooperation in the field of basic research at the MDC with the hospitals in Berlin-Buch, the hospitals of the Medical Faculties of the

Free University in Berlin-Steglitz (Klinikum Benjamin Franklin) and Wedding (Virchow-Klinikum) and the Medical Faculty of the Humboldt University (Charité Campus Mitte). By establishing the BerlinBuch Biotechnologie (BBB) company he promoted the transfer of technology and commercial utilisation of scientific results. This establishment grew into an independent biotechnology campus with incubatorson the Berlin-Buch campus and, in alliance with the MDC as main shareholder, developed into one of the most important biotechnology parks in Germany. In 2004, the Berlin Senate appointed Professor Ganten CEO of the Charité – Universitätsmedizin Berlin. Under his direction the locations of academic medicine in East and West Berlin were united. As a result of the merger with the "Universitätsklinikum Benjamin Franklin" of the Freie Universität, the Charité Berlin became a member of both universities and, with 3,500 beds and around 15,000 employees, the largest university hospital in Germany. Professor Ganten held the office of CEO of the Charité – Universitätsmedizin until 2008 when it was then handed to Professor Karl Max Einhäupl. The year 2005 saw the establishment of the Charité Foundation by donor Johanna Quandt and Professor Ganten. Since then, Professor Ganten has been acting Chairman of the Foundation Board. Support from the Charité Foundation helped to establish an increasingly closer association between the Charité – Universitätsmedizin and the Max Delbrück Center in Berlin-Buch. The formation of the "Berlin Institute of Health (BIH)" was founded in 2013 through an agreement of the Federal Ministry for Research and Technology and the Berlin Senate. The BIH provides a joint structure and platform for MDC and Charité to strengthen their clinical research initiatives. On occasion of the 300th anniversary of the founding of the Charité, Professor Ganten launched the World Health Summit and continues his association as Founding President of this annual Berlin event. Since 2009, Professor Ganten has been chairman of the joint Board of Trustees of the Max Planck Institutes of Colloids and Interfaces (MPI-KG) and Molecular Plant Physiology (MPI-MP) in Potsdam. Other memberships include: the Scientific Advisory Board of the Agence Nationale de Recherche Paris (France, since 2004); the Scientific Advisory Board of the Université Sorbonne Paris Cité (France, since 2011); the Board of Directors of the Université Paris Sciences et Lettres (France, since 2011) and the Scientific Advisory Board of the Einstein Foundation (since 2011). As part of the 50-year anniversary celebrations of the Elysée Treaty on Franco-German cooperation, an agreement between the French and German governments was signed in April 2013, constituting the establishment of the "Centre Virchow-Villermé for Public Health Paris-Berlin". Professor Ganten and Professor Jean-François Girard are co-chairs of the International Advisory Board of this new and important institution. Professor Ganten is deputy chairman of the “Group of Friends of the MDC” and patron of the program "Berlin der Begegnung" (Berlin Encounters / Genshagener Kreis) of the Einstein Foundation. In 2013 Professor Ganten was elected co-chair of the Interacademy Medical Panel (IAMP).

Fields of Research, Awards and Prizes Professor Ganten's major area of research is hypertension. He discovered basic mechanisms underlying the development of hypertension and is investigating the hormonal regulation of hypertension, in particular the renin-angiotensin-aldosteron system. Further key research interests include the genomic and molecular mechanisms of evolution and evolutionary medicine, concepts for the prevention of cardiovascular diseases, Public Health, Global Health and Bioethics.

His scientific work won Professor Ganten visiting professorships at the University of California, La Jolla, San Diego and the Salk Institute in 1983, at the Collège de France, Paris, in 2010 respectively. Professor Ganten is also an editor of the Journal of Molecular Medicine (since 1993). Detlev Ganten has been president and coordinator of numerous scientific conferences, among them: Scientific Meeting of the European and International Societies of Hypertension (Heidelberg 1986, Berlin 2008); Gordon Conference (1997, Italy); and the Annual Meeting of the Society of German Natural Scientists and Physicians (Gesellschaft Deutscher Naturforscher und Ärzte, GDNÄ – Berlin 1998). Professor Ganten has been the recipient of many international awards and prizes including the Chavez Award of the International Society of Hypertension; Sechenev Medal of the Medical Academy Moscow; Franz Gross Science Award of the German League for Combating High Blood Pressure (all in 1981 respectively); the Heilmeyer Medal of the Society for Progress in Internal Medicine (1990); the Max Planck Research Award (with Kazuo Murakami, Japan) (1991); the Okamoto Award, Japan (1991); the CIBA Award of the Council for High Blood Pressure Research of the American Heart Association (1992); and in 2013, the Humboldt Medal of the Society of German Natural Scientists and Physicians. Prof. Ganten was appointed Dr. honoris causa by the University of Iași, Romania in 1987, honorary professor by the University of Wuhan, P.R. China (1994), and the First Moscow State University (2004). Professor Ganten received the Order of Merit of the State of Berlin in 1997; the Federal Cross of Merit, Germany in 2000, and in 2012, the insignia of Officer of the Legion of Honor of the French Republic.

Functions in Scientific Societies and Committees Professor Ganten's functions in scientific societies and committees include: membership in the Berlin–Brandenburg Academy of Sciences (BBAW); the Heidelberg Academy of Sciences, the German National Academy of Sciences Leopoldina; the Academia Europaea, the Polish Academy of Sciences (Polska Akademia Umiejetnosci); and the Académie de Berlin. From 1992 to 1998 he was President of the World Hypertension League. Further memberships include the Health Research Council of the German Federal Ministry for Science and Technology from 1992 to 1997 and the Science Council of the German Federal Government from 1993 to 1998. Professor Ganten was President of the Society of German Natural Scientists and Physicians (1996– 1998); President of the Helmholtz Association of National Research Centers (1997–2001); and a member of the German National Ethics Council from 2001 to 2007. From 1995 to 2004 Professor Ganten was acting Vice President of the Berlin–Brandenburg Academy of Sciences (BBAW). He was President of the Comité International d’Orientation Scientifique et Stratégique (COSS) of the Collège de France from 2004 to 2012 and from 2001 to 2009 he had a seat on the Board of Directors of the Institut de la Santé et de Recherche Médicale (INSERM).

Selected Publications Ganten, D., Hayduk, K., Brecht, H.M., Boucher, R. and Genest, J. Evidence of renin release or production in splanchnic territory. Nature 226:551-552, 1970. Ganten, D., Minnich, J.L., Granger, P., Hayduk, K., Brecht, H.M., Barbeau, A., Boucher, R. and Genest, J. Angiotensin-forming enzyme in brain tissue. Science 173:64-65, 1971. Phillips, M.I., Mann, J.F.E., Haebara, H., Hoffman, W.E., Dietz, R., Schelling, P. and Ganten, D. Lowering of hypertension by central saralasin in the absence of plasma renin. Nature 270:445-447, 1977. Ganten, D., Hermann, K., Bayer, C., Unger, T. and Lang, R.E. Angiotensin synthesis in the brain and increased turnover in hypertensive rats. Science 221:869-871, 1983. Lang, R.E., Thölken, H., Ganten, D., Luft, F.C., Ruskoaho, H. and Unger, T. Atrial natriuretic factor: a circulating hormone stimulated by volume loading. Nature 314:264-266, 1985. Ganten, U., Schröder, G., Witt, M., Zimmermann, F., Ganten, D. and Stock, G. Sexual dimorphism of blood pressure in spontaneously hyperptensive rats: effects of anti-androgen treatment. Journal of Hypertension 7:721-726, 1989. Hackenthal, E., Paul, M., Ganten, D. and Taugner, R. Morphology, physiology, and molecular biology of renin secretion. Physiological Reviews 70:1067-1116, 1990. Mullins, J.J., Peters, J. and Ganten, D. Fulminant hypertensin in transgenic rats harbouring the mouse Ren-2 gene. Nature 344:541-544, 1990. Hilbert, P., Lindpaintner, K., Beckmann, J., Serikawa, T., Soubrier, F., Dubay, C., Cartwright, P., DeGouyon, B., Julier, C., Takahasi, S., Vincent, M., Ganten, D., Georges, M. and Lathrop, G. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353:521-529, 1991. Jacob, H.J., Lindpaintner, K., Lincoln, S.E., Kusumi, K., Bunker, R.K., Mao, Y.P., Ganten, D., Dzau, V.J. and Lander, E.S. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67:213-224, 1991. Lindpaintner, K. and Ganten, D. The cardiac renin-angiotensin system: an appraisal of present experimental and clinical evidence. Circulation Research 68:905-921, 1991. Schelling, P., Fischer, H. and Ganten, D. Angiotensin and cell growth: A link to cardiovascular hypertrophy? Journal of Hypertension 9:3-15, 1991. Ganten, D., Wagner , J., Zeh, K., Bader, M., Michel, JB., Paul, M., Zimmermann, F., Ruf, P., Hildenfeldt, U., Ganten, U., Kaling, M., Bachmann, S., Fukamazi, A., Mullins, JJ., Murakami, K. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proceedings of the National Academy of Sciences USA 89: 7806-7810, 1992. Ganten, D., Wagner, J., Zeh, K., Bader, M., Michel, J.B., Paul, M., Zimmermann, F., Ruf, P., Hilgenfeldt, U. and Ganten, U. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proceedings of the National Academy of Sciences USA 89:7806-7810, 1992.

Paul, M., Wagner, J., Hoffmann, S., Urata, H., Ganten, D. Transgenic rats: new experimental models for the study of candidate genes in hypertension research. Annual Review of Physiology 56:811-829, 1994. Pesquero, J.B., Lindsey, C.J., Zeh, K., Paiva, A.C.M., Ganten, D., Bader, M. Molecular structure of rat B2bradykinin receptor gene. Journal of Biological Chemistry 269:26920-26925, 1994. Sander, M., Ganten, D., Mellon, S.H. Role of andrenal renin in the regulation of adrenal steroidogenesis by corticotropin. Proceedings of the National Academy of Sciences USA 91:148-152, 1994. Kreutz, R., Hübner, N., James, M.R., Bihoreau, M.-T., Gauguier, D., Lathrop, G.M., Ganten, D., Lindpaintner, K. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proceedings of the National Academy of Sciences USA 92:8778-8782, 1995. Rubattu, S., Volpe, M., Kreutz, R., Ganten, U., Ganten, D., Lindpaintner, K. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nature Genetics Vol.13:429-434, August 1996. Schinke, M., Baltatu, O., Böhm, M., Peters, J., Rascher, W., Brica, G., Lippoldt, A., Ganten, D., Bader, M. Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen. Proceedings of the National Academy of Sciences USA 96:3975-3980, 1999. Nadeau, J.H., Balling, R., Barsh, G., Beier, D., Brown, S.D.M., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.-L., Hicks, G., de Angelis, M.H., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A., Rinchik, E.M., Rossant, J., Russell ,L.B., Schimenti ,J., Shiroishi, T., Skarnes, W.C., Soriano, P., Standford, W., Takahashi, J.S., Wurst, W., Zimmer, A. Functional Annotation of Mouse Genome Sequences. Science 291: 1251-1255, 2001. Bader, M., Peters, J., Baltatu, O., Müller, D.N., Luft, F.C., Ganten, D. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. Journal of Molecular Medicine 79: 76-102, 2001. Fändrich, F., Lin, X., Chai, G. X., Schulze, M., Ganten, D., Bader, M., Holle, J., Huang, D.S., Parvaresch, R., Zavazava, N., and Binas, B. Preimplantation-stage stem cells induce allogeneic graft tolerance without supplementary host conditioning. Nature Medicine 8:171-178, 2002. Rat Genome Sequencing Project Consortium. Genome Sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428:493-521, 2004. Ganten D. What is life? On Erwin Schrödinger, his cat, and the Journal of Molecular Medicine. Journal of Molecular Medicine (Berl) 85(12):1291-2, Dec. 2007. Bader, M., Ganten, D. Update on tissue renin-angiotensin systems. Journal of Molecular Medicine 86: 615-621, 2008. Ganten, D., Bader, M., Jürgensen, J.S. An old couple: the renin-angiotensin system (RAS) and the Journal of Molecular Medicine (JMolMed). Journal of Molecular Medicine (Berl) 86(6):609-10, Jun. 2008.

Bader, M. and Ganten, D. Update on tissue renin-angiotensin systems. Journal of Molecular Medicine (Berl) 86(6):615-21, Jun. 2008. Ganten, D., Semenza, G.L., Nolte, C. Fostering trust-- Mol Med's scientific integrity policy. Journal of Molecular Medicine (Berl) 87(1):1-2, Jan 2009. Adli, M., Kleinert, S., Lafont, A., Kahn, A., Ganten, D. Shaping future health: Berlin Evolution of Medicine Summit. Lancet 373(9663):519-20, 14 Feb. 2009. Adli, M., Kleinert, S., Smith, S.K., Ganten, D. Academic medicine must take its global role: the M8 Alliance of Academic Health Centers and Medical Universities. Lancet 376(9748):1197-8, 09 Oct. 2010. Ganten, D., Haines, A., Souhami, R. Health co-benefits of policies to tackle climate change. Lancet 376(9755):1802-4, 27 Nov. 2010. Adli, M., Kleinert, S., Bonk, M., Wesselingh, S., Ganten, D. Science to policy: M8 Alliance invites policy makers to step in. Lancet 378(9801):1447-9, 22 Oct. 2011. Nesse, R.M., Ganten, D., Gregory, T.R., Omenn, G.S. Evolutionary molecular medicine. Journal of Molecular Medicine 90(5):509-22, May 2012. Fournier, D., Luft, F.C., Bader, M., Ganten, D., Andrade-Navarro, M.A. Emergence and evolution of the renin-angiotensin-aldosterone system. Journal of Molecular Medicine (Berl) 90(5):495-508, May 2012. Ganten, D. and Nesse, R. The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine. Journal of Molecular Medicine (Berl) 90(5):467-70, May 2012.

Books Ganten, D., Deichmann, T. and Spahl, T. Leben, Natur, Wissenschaft – Alles, was man wissen muss. Eichborn AG, Frankfurt am Main. 2003. Ganten, D., Gerhardt, V., Nida-Rümelin, J. Funktionen des Bewusstseins. Walter de Gruyter, Berlin. 2008. Ganten, D., Gerhardt, V., Heilinger, J., Nida-Rümelin, J. Was ist der Mensch? Walter de Gruyter, Berlin. 2008. Ganten, D., Spahl, Th., Deichmann, Th. Die Steinzeit steckt uns in den Knochen – Gesundheit als Erbe der Evolution. Pieper, München. 2009.