CURRICULUM VITAE Frederick C. Lough, COL MC Current Position:

Deputy Chairman, Department of Surgery Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814 301-295-3155 Cardiothoracic Surgeon Walter Reed National Military Medical Center 8901 Wisconsin Ave, Bethesda, MD 20889 301-319-2837

Former Positions

Director of Cardiac Surgery (2005-2013) The George Washington University Hospital Clinical Professor of Surgery The George Washington University School of Medicine Washington, D.C. Interim Medical Director (August 2008-March 2009) The George Washington University Hospital Washington, D.C. Director, Military Medical Students (2005-2013) The George Washington University School of Medicine Washington, D.C.

General: Born:

Providence, Rhode Island

1966-1970 1971-1975

B.S. United States Military Academy, West Point, New York M.D. The George Washington University School of Medicine and Health Sciences, Washington, D.C.

1975-1976

Walter Reed Army Medical Center, Washington, D.C.

1976-1979

General Surgery Residency, Walter Reed Army Medical Center, Washington, DC Thoracic & Cardiovascular Surgery Residency, Walter Reed Army Medical Center, Washington, DC

Education:

Internship:

Residency:

1980-1982

Board Certifications: National Board of Medical Examiners Certification # 156184 American Board of Surgery Certificate # 25757 American Board of Thoracic Surgery Certificate #4011

1976 1980

Recertified 1989

1983

Recertified 1993, 2003, 2013

Professional Societies District of Columbia Medical Society Texas Medical Association Fellow, American College of Surgeons Fellow, American College of Cardiology The Society of Thoracic Surgery American Association for the Advancement of Science Southern Thoracic Surgical Association American Medical Association Association of Military Surgeons of the United States Military Service: 1970-1987 2007- 2013 2013- present 2010 2012 Rank: Branches:

United States Army Medical Corps United States Army Medical Corps Reserves United States Army Medical Corps Deputy Commander, NATO Role 2 Hospital Camp Arena, Herat, Afghanistan Senior Trauma Surgeon, FOB Shank, RC East, Afghanistan Colonel, United States Army Corps of Engineers and Medical Corps

Military Awards and Decorations: Combat Action Badge Meritorious Service Medal Army Commendations Medal (3) Army Achievement Medal Overseas Service Medal Afghanistan Campaign Medal (2) Global War on Terrorism Ribbon US Army Reserve Medal (Mobilized) (2) NATO Service Medal (2) National Defense Medical (2) Airborne Wings Ranger Tab Order of Military Medical Merit Meritorious Unit Citation 2010 Presidential Unit Citation

Military Training: 1970 1970 1970 1970 1970 1983 1983 1984 1984-1987 2006-2007 2007 2009

United States Military Academy, West Point, NY Airborne Training, Ft. Benning, GA Ranger Training, Ft. Benning, GA Engineer Officer, Basic Course, Ft. Belvoir, VA Engineer-in-Training, PA Nuclear Hazard Training Course Astronaut Selectee, U.S. Army Combat Casualty Care Course, TX Advanced Trauma Life Support Instructor National Incident Management System-Courses 100, 200, 700 Advanced Trauma Life Support Instructor Joint Forces Combat Trauma, Management Course, San Antonio, TX

Positions: 3/1971-7/1971 Officer of Personnel Operations, U.S. Army, Corps of Engineers 8/1971-5/1975 George Washington University School of Medicine, Washington, D.C. Awarded M.D. 6/1975-7/1979 Walter Reed Army Medical Center- Internship and Residency in General Surgery, Washington, D.C. 8/1979-7/1980 Staff Surgeon, Department of Surgery, 121st Evacuation Hospital Seoul, South Korea 8/1980-6/1982 Walter Reed Army Medical Center- Fellowship in Thoracic and Cardiovascular Surgery, Washington, D.C. 7/1982-8/1985 Assistant Chief, Cardiothoracic Surgery Service, Walter Reed Army Medical Center, Washington, D.C. 9/1985-9/1987 Chief, Cardiothoracic Surgery Service, Letterman Army Medical Center, San Francisco, CA

10/1987-5/1994 Surgeon to the Hospital, Department of Surgery, Section of Cardiothoracic Surgery, the Reading Hospital and Medical Center, West Reading, Pennsylvania 6/1994-7/2004 Chief of Cardiac Surgery, Reading Hospital and Medical Center Reading, Pennsylvania 2000-Present Adjunct Associate Professor of Surgery, Uniformed Services of University Health Sciences, Washington, D.C. 8/2004-8/2005 Private Practice Cardiac Surgery, McAllen, Texas 2005-2013 Director, Cardiac Surgery Program, The George Washington University Medical Center, Washington, D.C. 2007-2013 Director, Military Medical Students, The George Washington University Medical Center, Washington, D.C. 2010 Deputy Commander, NATO Role 2 Hospital Camp Arena, Herat, Afghanistan, 4th Brigade, 82nd Airborne Div. 2012 Senior Trauma Surgeon, 628th and 624th Forward Surgical Teams Forward Operating Base Shank, Afghanistan, 173rd Airborne. 2013- present Cardiothoracic Surgeon, Walter Reed National Military Medical Center, Bethesda, Maryland 2013- present Deputy Chairman, Department of Surgery Uniformed Services University of the Health Sciences, Bethesda, Maryland

Honors: 1964 1967-1970 1967-1970 1967 1973

1973-1975 1975 1974 1979 1983 1999-2004 2004-2008 2004-2008 2007

Eagle Scout Dean’s List, United States Military Academy, West Point, NY Lettered, Swimming, United States Military Academy, West Point, NY Stephan Childers Award, Army Athletic Association, West Point, NY National Aeronautics & Space Administration Certificate of Achievement, Skylab Project, Johnson Space Center, Houston, TX Class President, George Washington University School of Medicine Alec Horowitz Award for Excellence in Surgery, George Washington University School of Medicine Alpha Omega Alpha, George Washington University School of Medicine Association of Military Surgeons of the United States Honor Award Commandant’s Award, Walter Reed Army Medical Center Board of Trustees, Reading Symphony, Reading, PA Board of Trustees, The University of Texas-Pan American Foundation, McAllen, TX Board of Trustees, The Museum of the Pacific War Fredericksburg, TX Hospital Association Patient Safety Award, Cardiac Surgery Program George Washington University Hospital, Washington, D.C.

2008, 2009 2010-2011 2014

Top Doctors Award, Washington, D.C. Barry Goldwater Service Award, Uniformed Services University of the Health Sciences, Bethesda, MD Top Doctors Award, Washington, D.C. Michael E. DeBakey International Military Surgeons’ Award for Excellence, Uniformed Services University of the Health Sciences

Position at The Reading Hospital & Medical Center: (650 beds, 500 to 850 open heart procedures per year) Chief, Section of Cardiovascular Surgery Co-chairman, Cardiac Services Committee Member, Joint Conference Committee Member, Critical Care Committee Activities at the Reading Hospital and Medical Center: 1. Participated in multiple newspaper and magazine articles, as well as radio and television programs designed to raise awareness of heart disease and possibilities for treatment in the community. 2. Created symphonic music compact disc designed to reduce stress following open heart surgery. Program developed with Maestro S. Rothstein, Director of the Reading Symphony, and Ms. Vicki Smith, Director, Surgical Intensive Care Unit. This effort was highly successful and was expanded to include Obstetrical, Chemotherapeutic, and Emergency Room Services. Total cost to develop and run program was zero dollars. 3. Between 1987 and 2004, performed or participated in 10,000 open heart procedures. 4. Became Chief of Cardiothoracic Surgery in 1994, and initiated an across the board review of cardiac surgery which resulted in significant cost reduction. 5. Initiatives: Introduced the use of endoscopic saphenous vein harvesting, the use of shorter acting anesthetics, and the use of surgical glues for wound healing. These efforts resulted in less patient discomfort, earlier ambulation, and a reduced length of stay. (avg. length post cabg 5.9 days in 2003) 6. Participated for 14 years in the Pennsylvania Health Care Cost Containment Council Review of Coronary Artery Bypass Grafting. 7. Teaching: Multiple lectures and seminars for medical students from Philadelphia, for nursing students at the Reading Hospital School of Nursing, and for members of the general public attending health care seminars.

Responsibilities and Initiatives at the George Washington University Hospital, Washington, D.C.

1. Supervised all aspects of the Cardiac Surgery Program and oversee the participation in the Society of Thoracic Surgeons National Databank. Achieved Three Star Rating for Absence of Complications Following Cardiac Surgery. 2. Instructed Medical Students, Interns, and Residents at George Washington University and the Uniformed Services University of the Health Sciences. 3. Introduced a System Based approach to the practice of Cardiac Surgery. This streamlined the preoperative, intraoperative and postoperative care of the patient. This approach also resulted in a marked reduction in postoperative complications and in significant cost savings. The improvements were recognized in the first 3 Star Rating given to George Washington University Hospital by the Society of Thoracic Surgeons. 4. Co-chairman of the Transfusion Committee. Coordinated the introduction of efficient blood bank practices and improved communication with clinicians across multiple specialties. This resulted in a 50% reduction in blood usage and also reduced wastage. 5. Supervised the introduction of the Adult Extracoporeal Membrane Oxygenation Program, improving the care of severely ill patients.

6. Served as Director of the Health Professional Scholarship Students. This is the largest program in the United States. Directly advising students and assisting them with their career choices.

Duties at the Uniformed Services University of the Health Sciences

1. As Deputy Chairman of the Department of Surgery, assist the Chairman of Department in accomplishing the mission of Educating the Military Medical Students, caring for patients throughout the Military Health System and encouraging and developing high quality Research, advancing medical knowledge. Directly teaching medical students in the craft of Surgery, with particular emphasis on providing surgical care in hostile environments. Serving as an instructor in Gross Anatomy, enlightening students on the clinical relevance of the anatomic knowledge. Teaching the Advanced Trauma Life Support Course offered to our medical students, and physicians and surgeons. Support the Admissions Department’s effort, to select the highest quality candidates to attend USUHS. Participate as Instructor for Operation Bushmaster and Operation Gunpowder Falls.

Publications: 1. “Regional Hemodynamics of Large and Small Femoral Arteriovenous Fistulae in Dogs. “ SURGERY 79:346, 1975, Lough FC, Giordano J., Hobson R. 2. “Regional Hemodynamics of Large and Small Femoral Arteriovenous Fistulae in Dogs.” (Abstract). CLIN RES 23:83 A, 1975, Lough FC, Giordano J, Hobson R. 3. “Iatrogenic Internal Hernia: Report of an Unusual Case Involving the Iliac Artery.” ANN SURG, July 1978, Guba A, Lough FC, Collins G, Feaster M, Rich N. 4. “Recurrent Subluxation of the Shoulder.” (Motion Picture). Feaglin 5, Lough FC, Woodward U, AMER. Academy of ORTHOPEDIC SURGEONS, 1976. 5. “Mammoth Inguinal Hernia Repair.” (Motion Picture). Lough FC, Harmon J, Hirata R, AMER. COLLEGE OF SURGEONS, San Francisco, CA. 6. “Initial and Long-Term Results in the Management of Primary Chest Wall Neoplasms.” ANN THORACIC SURG., 34:664, 1982, Graeber GM, Snyder RG, Fleming AW, Head ND, Lough FC, Parker JS, Zajtchuk R., Brott WH. 7. “Results of Myocardial Revascularization in Black Males.” AM HEART J. 108:695-699, 1984, Sterling RP, Graeber GM, Albus RA, Burton NA, Lough FC, Fleming AW. 8. “The Heart.” U.S. NEWS AND WORLD REPORT, 1983. (Picture Consultant). 9. “Coronary Artery Aneurysm Complicating Bypass Tract Surgery for WolffParkinson-White Syndrome.” AMER J. OF CARDIOLOGY, December 1983, Shuck J, Cohen I, Cohen D, Lough FC. 10. “Intraoperative Coronary Artery Spasm Following Withdrawal of Calcium Antagonist.” (Letter). ANN OF THOR SURGERY, March 1985. 11. “Lidocaine Duringer Reperfusion to Prevent Ventricular Fibrillation.” Fall SM, Burton NA, Graeber GM, Zajtchuk R, Lough FC, Head HD, Antopol MR. (Accepted for publication in Annals of Thoracic Surgery). 12. Robotic Thoracoscopic Heller Myotomy for Achalasia. (Oral Presentation), MIRA Congress 2008. Margolis, M., Gharagozloo, F., Lough, F., Tempesta, B., Strother, E. 13. Robotic Lobectomy for Early Stage Lung Cancer. (Oral Presentation), MIRA Congress 2008. Gharagozloo, F., Margolis, M., Tempesta, B., Lough F., Strother, E.

14. Robotic-Assisted Abdomen/Right Chest (IVOR Lewis) Esophagogastrectomy for Esophageal Cancer. (ORAL presentation), MIRA Congress, 2008. Gharagozloo, F., Margolis, M., Tempesta, B., Lough, F., Strother, E. 15. Robotic Thoracoscopic Heller Myotomy for Achalasia. (Video Presentation), MIRA Congress 2008. Margolis, M., Gharagozloo, F., Lough, F., Tempesta, B., Strother, E. 16. Robotic Left Lower Lobectomy for Early Stage Lung Cancer-Video Presentation of Robot Positioning and Operative Technique (Video Presentation), MIRA Congress, 2008. Gharagozloo, F., Margolis, M., Tempesta, B., Lough F., Strother, E. 17. Robotic Right Lower Lobectomy for Early Stage Lung Cancer-Video Presentation of Robot Positioning and Operative Technique (Video Presentation), MIRA Congress, 2008. Gharagozloo, F., Margolis, M., Tempesta, B., Lough F., Strother, E. 18. A System Based Approach to Cardiac Surgery Resulted in Improved Survival, Reduced Morbidity and Significant Cost Savings, submitted to the Society of Thoracic Surgeons for publication, 6/09. 19. Textbook of Robotic Surgery, McGraw-Hill, New York, 2009. 20. Off-Pump versus On-Pump Coronary Artery Bypass Grafting Outcomes Stratified by Preoperative Renal Function. JOURNAL of the AMERICAN SOCIETY OF NEPHROLOGY 23 2012. Chawla, L., Lough, F., Schroeder, E., Seneff, M., Brennan, J., Presentations: 1. “Advances in Cardiac Surgery” George Washington University Hospital, Washington, DC November 2005. 2. “Timing of Cardiac Surgery: Impact on Postoperative Care” Cardiothoracic Surgical Critical Care 2006, Washington, DC 28 April 2006. 3. “Cardiac Surgery, A System Based Approach to Improving Care” Uniformed Services University for the Health Sciences, Bethesda, Maryland, August 2006. 4.

“ Innovations in Cardiac Surgery and Medicine as a National Security Issue” Industrial College of the Armed Forces, Washington, D.C., 7 March 2007.

5. “Innovations in Cardiac Surgery and Medicine as a National Security Issue” Industrial College of the Armed Forces, Washington, D.C., 7 March 2008.

6. “2+2 Does Not Equal 4, Cardiac Surgery Now and Future” Uniformed Services University for the Health Sciences, Bethesda, Maryland, August 2008. 7.

“Innovations in Cardiac Surgery and Medicine as a National Security Issue” Industrial College of the Armed Forces, Washington, D.C., January 2009.

8.

“Surgery in a Combat Zone, Afghanistan” Uniformed Services University for the Health Sciences, Bethesda, Maryland, August 2010

9. “Surgical Experience in Afghanistan” Presented to Department of Medicine June 2010 and Department of Surgery September 2010. George Washington University Hospital, Washington, D.C. 10. “Opportunities for Thoracic Surgeons to Serve Their Country,” Society of Thoracic Surgeons Meeting, San Diego, CA, February 2011 11. “Innovations in Cardiac Surgery and Medicine as a National Security Issue” Industrial College of the Armed Forces, Washington, D.C. March 2011 12. “One Surgeons Perspective on the Surgical and Ethical Challenges of Military Medical Care in Afghanistan”, Yale School of Medicine, New Haven, CT, April 2011. 13. “Afghanistan, Combat Medicine and the Future”. Distinguished Professor Lecture, Department of Surgery, The Walter Reed National Military Medical Center, Bethesda, MD. Dec 2012.

Research: 1. QRK.002: A Phase I, Randomized, Single-Blind, Dose Escalation Trial of The Safety and Pharmokinetics of a Single Intravenous Injection of 15NP in Patients Undergoing Major Cardiovascular Surgery.  Note: Patient received anti-sense gene after open heart surgery which temporarily shuts off aptosis gene in renal cells, hopefully preserving renal function. 

Sports Participation

3 patients in the world have received this medication-patient #1 and #3 done at George Washington University Hospital.

West Point Triathalon Army Ten Miler Marine Corps Marathon Adventure Challenge Army Ten Miler Marine Corp Marathon

2006 2006 2006 2007 2007 2007