Curriculum Vitae

Personal Name:

Grzegorz (”Greg”) A. Rempala

Citizenship:

US

Home Address:

4254 Randmore Rd Columbus, OH 43220

Phone: E-mail:

(614) 292-0006 [email protected]

Office Division of Biostatistics Address: The Ohio State University Columbus, OH 30912 Phone: (614) 247-6289 Web URL: https://neyman.cph.ohio-state.edu

Education and Professional Degrees 2007

D.Sc. Habilitatus (post-doctoral degree) Warsaw Technical University, Warsaw, Poland

1998

Ph.D., Applied Mathematics (US degree conferral) Department of Mathematics, University of Warsaw, Warsaw, Poland Chair of the conferral committee: Dr. S. Kwapien´

1996

Ph.D., Mathematical Statistics Department of Mathematics and Statistics Bowling Green State University, OH, USA Advisor: Dr Arjun K. Gupta

1992

M.A. Summa Cum Laude, Mathematics Department of Mathematics University of Warsaw, Warsaw, Poland ´ Advisor: Dr R. Zielinski

Professional Positions 2013–

Deputy Director, Mathematical Biosciences Institute Professor of Biostatistics, College of Public Health Professor of Mathematics (courtesy), College of Arts and Sciences The Ohio State University, Columbus, OH

Fall 2011

Visiting Research Professor, Mathematical Biosciences Institute The Ohio State University, Columbus, OH

2008–2012

Director of Biostatistics and Bioinformatics Core Cancer Research Center, Georgia Regents University

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(former Medical College of Georgia) Professor, Department of Biostatistics Georgia Regents University, Augusta, GA 2007–08

Professor of Statistics Department of Mathematics (College of Arts and Science) and Department of Biochemistry and Molecular Biology (School of Medicine) University of Louisville, KY

2006–08

Associate Professor of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, KY (joint appointment with Mathematics).

2006–08

Director, Computational Biology Core Center for Genetics and Molecular Medicine University of Louisville

Fall 06

SAMSI Senior Research Fellow, Statistical and Applied Mathematical Sciences Institute, Durham, NC

Fall 05 & Summer 04

Visiting Research Fellow, Statistical and Applied Mathematical Sciences Institute and Institute of Statistics and Decision Science, Duke University, Durham, NC

2003–04

Visiting Research Fellow, Institute for Mathematics and Its Applications, University of Minnesota, Minneapolis, MN

2003–04

Visiting Professor, Department of Mathematics University of Minnesota, Minneapolis, MN

2002–2007

Associate Professor of Statistics, Department of Mathematics, University of Louisville, Louisville, KY

Summer 2001

Visiting Research Professor, Department of Statistics, Stanford University, Palo Alto, CA

1999- 2002

Director, Occupational Biostatistics Unit, Division of Occupational Toxicology, University of Louisville Medical School, Louisville, KY

1999-2004

Associate Assistant Professor, Department of Family and Community Medicine, University of Louisville Medical School, Louisville, KY

1996-2002

Assistant Professor, Department of Mathematics, University of Louisville, Louisville, KY

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Summer 1999, 2000

Research Fellow, Center for Mathematical Sciences, University of Wisconsin-Madison, Madison, WI

1992-1995

Assistant Project Statistician, OHM Environmental Services Corp., Findlay, OH, USA

1992-1996

Graduate Assistant,Bowling Green State University, Bowling Green, OH

1991-1992

Junior Research Associate, Institute of Computer Science, Polish Academy of Science, Warsaw, Poland

Interdisciplinary Research Groups 2014–15

Ebola Modeling Coordination (Biomedical Advanced Research and Development Authority, US Department of Health and Human Services or HHS) 2006–11 Focused Research Group: Intracellular Models of Chemical Reactions (UofL, U. Wisconsin, Cornel U. and UCSD) 2007–08 Stochastic Multiscale Approximations in Cellular Systems (Statistical and Applied Mathematical Sciences Institute Program on Computer Modeling) 2005–06 Agricultural Networks & and Anomaly Detection (Statistical and Applied Mathematical Sciences Institute, Program on National Defense and Homeland Security)

Honors and Awards 2007

D.Sc Habilitatus (post-doctoral) Degree in Mathematical and Technical Sciences (Warsaw Technical University) 2006 Senior Research Fellowship (Statistical and Applied Math Sciences Institute) 2002 Scientific Committee Membership, Midwestern Probability Colloquium (Northwestern University) 2001 NSF Young Investigators Fellowship (Statistics Department, Stanford Universty) 2000, 1999 NSF Fellowship and Summer Internship (Center for Mathematical Sciences, University of Wisconsin-Madison) 1999 Victor A. Olorunsola Research Award (University of Louisville) 1992 National Graduate Research Award (Polish Ministry of Higher Education)

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Research Funding Current

DMS1513489 PI G. Rempala RAPID-Stochastic Ebola Modeling on Dynamic Contact Networks National Science Foundation, 2014-2016 DMS1106485 PI G. Rempala Biochemical Network Models with Next Gen Sequencing. National Science Foundation, 2011-2016. R01CA152158 PI G. Rempala, Statistical Methods for Analyzing Antigen Receptors Data. NIH-National Cancer Institute, 2010-2016. Past R01DE019243, R01DE019243-S1 PI G.Rempala, D. Darling Mathematical Model of Parotid Acinar Differentiation. NIH-National Institute of Dental and Craniofacial Research, 2008-2013. DMS0840695, DMS0941113 PI G. Rempala, Focused Research Group: Intracellular Models of Reaction Networks. National Science Foundation, 2008-2012. DMS0553701 PI Rempala, G. Focused Research Group: Intracellular Models of Reaction Networks. National Science Foundation, 2006-2008. P30ES014443-02 PI Ramos, K and Rempala, G. Co-I . Center for Environmental Genomics and Integrative Biology (CEGIB) NIH-National Institute of Environmental Health Sciences, 2007-2008. R15CA106248-02 PI Rempala, G. and Gill, R. Co-I Joinpoint Regression Model in Cohort Studies. NIH-National Cancer Institute, 2005-2007. PI Rempala, G. High Dimensional Inference and Random Matrices. National Science Foundation (via sub-contract with Duke University). 2006-07. PI Lewis, R., Rempala, G., and Winters C. Co-PI’s Serum Inhibin B Levels in Male Polymer Production Workers Center for Disease Control and National Institute of Occupational Safety and Health. 2001-2003. PI Lewis, R. Rempala, G. and Fortwengler, P. Co-PI’s Brain Cancer Occurrence in VC Exposed Louisville Chemical Plant Workers. Chemical Manufacturers Association 1997-99, research contract VCH 6.0 EPI. PI Rempala, G. and Ostaszewski, K. Co-I Possible Applications of Bootstrap in Actuarial Science. Society of Actuaries 1998-99.

Selected Publications Books and Book Chapters Rempala, G.A. and Wesolowski J. Symmetric Functionals on Random Matrices and Random Matchings Problems. Springer Series of the Institute for Mathematics and Its Applications. Hardcover, Springer-Verlag, New York 2008 ISBN-13: 978-0387751450

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Gill, R., Holden, F. and Rempala, G.A. Binomial p-spline regression for anomaly detection in cohort mortality patterns. In Data Mining and Management Spencer L.I. editor. Nova Science Publishers, New York, 2010. Ostaszewski, K. and Rempala,G.A. Emerging Applications of the Resampling Methods in Actuarial Models. In Intelligent Techniques In The Insurance Industry: Theory and Applications. Hardcover. Pub. World Scientific, 2003. Rempala,G.A. and Looney, S.W Power of the rank test for case-control studies with ordinal exposure. In Biostatistical Methods. Looney, S.W. editor. Humana Press, New Jersey, 2001. Journal Articles 1. Burch M, Jacobsen K, Tien J, Rempala GA Network-Based Analysis of a Small Ebola Outbreak. Math. Biosci. 2016 (in press). 2. Webb A, Papp AC, Curtis A, Newman LC, Pietrzak M, Seweryn M, Handelman SK, Rempala GA, Wang D, Graziosa E, Tyndale RF, Lerman C, Kelsoe JR, Mash DC, Sadee W. RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. BMC Genomics. 2015 Nov 23;16(1):990. doi: 10.1186/s12864-015-2207-8. PMID: 26597164 3. Szurek, A., Cebula, A., Wojciech, L., Pietrzak, M., Rempala, GA, Kisielow, P., and Ignatowicz L. Differences in expression level of Helios and Neuropilin-1 do not distinguish thymus-derived from extrathymically-induced CD4+Foxp3+ regulatory T cells. PLoS One 10(10):e0141161 (2015). DOI: 10.1371/journal.pone.0141161. 4. Schwartzbaum J, Seweryn M, Holloman C, Harris R, Handelman SK, Rempala GA, et al. Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma. PLoS ONE 10(9): e0137503 (2015). DOI:10.1371/journal.pone.0137503 5. Mascarenhas R, Pietrzak M, Smith RM, Webb A, Wang D, Papp AC, Pinsonneault, J., Seweryn, M., Rempala, G.A. Sadee, W. Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms. PLoS ONE 10(9): e0136798. (2015). DOI:10.1371/journal.pone.0136798 6. Fessel, K., Gaither, J., Bower, J., Gaillard, T. , Osei, K. and Rempala, G.A. Mathematical analysis of a model for glucose regulation. Mathematical Biosciences and Engineering (2015). In press. 7. Zigmont V, Garrett A, Peng J, Seweryn M, Rempala GA, Harris R, Holloman C, Gundersen TE, Ahlbom A, Feychting M, Johannesen TB, Grimsrud TK, Schwartzbaum J. Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma. Nutrition and Cancer. 28:1-11 (2015). DOI:10.1080/01635581.2015.1073757 8. Lu, R., Smith, R.M., Seweryn, M.T., Wang, D., Hartmann, K., Webb, A. Sadee, W., Rempala G.A. Analyzing allele specific RNA expression using mixture models. BMC Genomics 16:(1) 566 (2015). DOI:10.1186/s12864-015-1749-0

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9. Sturrock, M., Hao, W., Schwartzbaum, J., and Rempala, G.A. A mathematical model of pre-diagnostic glioma growth. Journal of Theoretical Biology 380(7):299–308 (2015). DOI:10.1016/j.jtbi.2015.06.003 10. Linder, Daniel F. and Rempala, G.A. Bootstrapping Least Squares Estimates in Biochemical Reaction Networks. Journal of Biological Dynamics 9(1):125–146 (2015). DOI:10.1080/17513758.2015.1033022 11. Schwartz, E., Choi, B. and Rempala, G.A. Estimating Epidemic Parameters: Application to H1N1 Pandemic Data. Mathematical Biosciences 2015. In press. DOI:10.1016/j.mbs.2015.03.007 12. Wojciech, L., Ignatowicz, A., Seweryn, M., Rempala, G.A., Pabla, S., McIndoe, R. , Kisielow, P. and Ignatowicz, L. The same self-peptide selects conventional and regulatory CD4+ T cells with identical antigen receptors. Nature Communications 1;5:5061 (2014) DOI: 10.1038/ncomms6061. PubMed PMID: 25270305; PubMed Central PMCID: PMC4183978. 13. Linder, D. and Rempala, G.A. Algebraic Statistical Model for Biochemical Dynamics Inference. Journal of Coupled Systems and Multiscale Dynamics 1, 468-475 (2013) DOI: 10.1166/jcsmd.2013.1032 14. Hallgren, J., Pietrzak, M., Rempala, G.A., Nelson, P.T, and Michal Hetman, M. Neurodegeneration associated instability of ribosomal DNA Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842(6):860–868 (2014). DOI:10.1016/j.bbadis.2013.12.012 15. Sadee W, Hartmann K, Seweryn M, Pietrzak M, Handelman SK, Rempala GA. Missing heritability of common diseases and treatments outside the protein-coding exome. Human Genetics 133(10):1199–215 (2014). DOI:10.1007/s00439-014-1476-7 16. Cebula, A., Seweryn, M., Rempala, G.A., Pabla, S., McIndoe, R., Denning, T., Bry, T. L., Kraj, P., Kisielow, P. and Ignatowicz, L. Thymus-derived regulatory T-cells control tolerance to commensal microbiota. Nature 497(7448):258–62 (2013). DOI:10.1038/nature12079 17. Kim, J. Li, J. Venkatesh S.G., Darling, D.S. and Rempala, G.A. Model Discrimination in Dynamic Molecular Systems: Application to Parotid De-differentiation Network. Journal of Computational Biology 20(7):524–39 (2013). DOI: 10.1089/cmb.2011.0222 18. Green, J., Birtwistle, M., Ignatowicz, L. and Rempala, G.A. Bayesian multivariate Poisson abundance models for T-cell receptor data. Journal of Theoretical Biology 326:1–10 (2013). DOI: 10.1016/j.jtbi.2013.02.009. ´ 19. Bobecka, K., Hitczenko, P., Lopez-Bl´ azquez, F., Rempala, G.A. and Wesolowski, J. Central limit theorems through factorial cumulants and partitions identities. Combinatorics, Probability and Computing, 22(2): 213–240 (2013). DOI: 10.1017/S0963548312000545 20. Rempala,G.A. and Yang, Y. On Permutation Procedures for Strong Control in Multiple Testing with Gene Expression Data. Statistics and Its Interface, 6: 79–89 (2013).

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21. Rempala, G.A. and Seweryn, M. Methods for diversity and overlap analysis in Tcell receptor populations. Journal of Mathematical Biology 67(6-7):1339-68 (2013). DOI: 10.1007/s00285-012-0589-7 22. Rempala, G.A. Least Squares Estimation in Stochastic Biochemical Networks Bulletin of Mathematical Biology, 274(8):1938-55 (2012). DOI:10.1007/s11538-012-9744-y 23. Bastian, C. and Rempala, G.A. Gene Selection with Classification and Regression Trees. Biostatistics, Bioinformatics and Biomathematics 2(4): 157-186 (2012). 24. Craciun, G., Kim, J., Pantea C., Rempala G.A. Statistical Model for Biochemical Networks Inference. Communications in Statistics: Simulation and Computation, 42(1): 121– 137 (2012). DOI:10.1080/03610918.2011.633200 25. Rempala, G.A. and Choi., B. Inference for Discretely Observed Stochastic Kinetic Networks with Applications to Epidemic Modeling. Biostatistics, 13(1): 153–165 (2012). DOI:10.1093/biostatistics/kxr019 26. Pietrzak M, Rempala, G.A., Nelson PT, Zheng JJ, Hetman M. Deletion of the ProApoptotic Endoplasmic Reticulum Stress Response Effector CHOP Does Not Result in Improved Locomotor Function after Severe Contusive Spinal Cord Injury PLoS One, 6(7):e22585 (2011). Epub 2011 Jul 22. PMID: 21933012 27. Rempala, G.A., Seweryn M, Ignatowicz L. Model for comparative analysis of antigen receptor repertoires. Journal of Theoretical Biology Volume 269(1), 1–15 (2011). DOI:10.1016/j.jtbi.2010.10.001 28. Kuczma M. Kopij M. Pawlikowska I. Wang C. Rempala, G.A. Kraj P. Intratumoral convergence of the TCR repertoires of effector and Foxp3+ CD4+ T cells. PLoS ONE 5(10):e13623 (2011). DOI: 10.1371/journal.pone.0013623 29. T.S. Kalbfleisch, Rempala, G.A., K.S. Ramos Genomics, Bioinformatics, and Computational Biology Comprehensive Toxicology Vol 2, Chap 2.33, 641–661 (2010). DOI:10.1016/B9780-08-046884-6.00236-0 30. Teng Y, Xie X, Walker S, Rempala, G.A., Kozlowski DJ, Mumm JS, Cowell JK. Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizurelike behavioral phenotype. Human Molecular Genetics. 19(22):4409-20 (2010). DOI: 10.1093/hmg/ddq364 31. Hetman M, Vashishta A, Rempala, G.A.. Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition. Journal of Neurochem. 114(6):1537–49 (2010). DOI: 10.1111/j.1471-4159.2010.06859. 32. Gheorghe Craciun, Casian Pantea, Rempala, G.A. Algebraic Methods for Inferring Biochemical Networks: a Maximum Likelihood Approach. Computational Biology and Chemistry vol. 33, no 5, pp 361–367 (2009). DOI:10.1016/j.compbiolchem.2009.07.014.

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33. Gill, R, Rempala, G.A. and M Czajkowski Confidence Estimation via the Parametric Bootstrap in Logistic Joinpoint Regression. Journal of Statistical Planning and Inference, vol. 139, no 9, pp. 3132–31412 (2009). DOI:10.1016/j.jspi.2009.02.017. 34. M Kuczma, I Pawlikowska, M Kopij, R Podolsky, Rempala, G.A., P Kraj TCR repertoire and Foxp3+ expression dene functionally distinct subsets of CD4+ Treg cells Journal of Immunology, vol. 183 pp. 3118–3129 (2009). 35. Kristen A. Stauffer Thompson, Rempala, G.A., and John Yin Multiple-hit Inhibition of Infection by Defective Interfering Particles. Journal of General Virology vol. 90, 888–899 (2009). DOI 10.1099/vir.0.005249-0 36. Rempala, G.A. and Pawlikowska, I. Limit Theorems for Hybridization Reactions on Oligonucleotide Microarrays. Journal of Multivariate Analysis vol. 99, no 9, pp. 2082– 2095 (2008). DOI:10.1016/j.jmva.2008.02.014 37. Czajkowski, M, Gill, R, and Rempala, G.A. Model Selection in Logistic Joinpoint Regression with Applications to Analyzing Cohort Mortality Patterns. Statistics in Medicine vol. 27, no 9, pp. 1508–1526 (2008). DOI: 10.1002/sim.3034 38. Rempala, G.A. Ramos K, Kalbfleisch, T, and Teneng, I. Validation of a Mathematical Model of Gene Transcription in Aggregated Cellular Systems: Application to L1 Retrotransposition. Journal of Computational Biology 14(3): 339–349 (2007). 39. Amar V. Singh, Eric Rouchka, Rempala, G.A., Caleb Bastian, and Thomas B. Knudsen. Integrative database management for mouse development: Systems and concepts. Birth Defects Research (Part C), 81, 1–19 (2007). 40. P. Bai, H.T. Banks, S. Dediu, A.Y. Govan, M. Last, A. Lloyd, H.K. Nguyen, M.S. Olufsen, Rempala, G.A., and B.D. Slenning. Stochastic and deterministic models for agricultural production networks. Mathematical Biosciences and Engineering, 4(3):140, (2007). 41. Rempala, G.A., Ramos, K. and Kalbfleisch, T. A Stochastic Model of Gene Transcription: An Application to L1 Retrotransposition Events. Journal of Theoretical Biology 242 (1), 101–116 (2006). 42. Ball, K., Kurtz, T., Popovic L., and Rempala, G.A. Multiscale stochastic approximations for biochemical reaction networks. Annals of Applied Probability 16(4), 1925–1961 (2006). 43. Gonchigdanzan, K. and Rempala, G.A. Almost sure limit theorem for the product of partial sums. Applied Mathematics Letters, 19(2), 191–196 (2006). 44. Rempala, G.A. and Looney, Stephen Asymptotic properties of a two sample randomized test for partially dependent data. Journal of Statistical Planning and Inference, 136(1), 68–89 (2006). 45. Rempala, G.A. and Wesolowski, J. Asymptotics for products of independent sums with application to Wishart determinants. Statistics and Probability Letters, 74(2), 129– 138 (2005).

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46. Rempala, G.A. and Derrig, Richard. Hidden exposures and EM algorithm North American Actuarial Journal, 9(2), 108–128 (2005). 47. Rempala, G.A. and Wesolowski, J. Approximation theorems for random permanents and associated stochastic processes. Probability Theory and Related Fields, 131(3), 442–458 (2005) 48. Rempala, G.A. and Wesolowski, J. Limit theorems for random permanents for matrices of exchangeable columns. Journal of Multivariate Analysis, 91, 224–239 (2004). 49. Rempala, G.A. and Srivastav, S. Minimum variance rectangular design for U -statistics. Journal of Statistical Planning and Inference, 120 (1-2), 103–118 (2004). 50. Rempala, G.A.. Factorial power expansions for binomial and negative binomial reciprocals. Proceedings of the Amer. Math. Soc., 132 261–271 (2004). 51. Rempala, G.A. and K. Szatschneider. Bootstrapping mortality tables. Scandinavian Actuarial Journal, no 1: 53–78 (2004). 52. Lewis, R. and Rempala, G.A. case-cohort study of angiosarcoma of the liver and brain cancer at a polymer production plant Journal of Occupational and Environmental Medicine, 45 538–545 (2003). 53. Rempala, G.A. and Wesolowski, J. Incomplete U -statistics of permanent design. Journal of Nonparametric Statistics 15 no. 2, 221–236 (2003). 54. Lewis, R., Rempala, G.A., Mundt, C., and Dell, L. Vinyl chloride and liver and brain cancer at a polymer production plant in Louisville, Kentucky. Journal of Occupational and Environmental Medicine 45, 533–537 (2003). 55. Rempala, G.A. and Derrig, R. EM Algorithm and Detecting Hidden Risks in Actuarial Practice. Forum of the Casualty Actuarial Society, Winter, 75–101 (2003). 56. Rempala, G.A. and Wesolowski, J. Strong law of large numbers for random permanents. Probab. Math. Statist., 22(2), 201–209 (2002). 57. Komendarczyk, Rafal and Rempala, G.A. Multivariate Cuzick test. Journal of Nonparametric Statistics, 14 no. 4, 367–382 (2002). 58. Rempala, G.A. and Wesolowski, J Asymptotics for Products of Sums and U-statistics. Electronic Communications in Probability, 7 47–54 (2002). 59. Rempala, G.A. and Wesolowski, J Central limit theorem for random permanents for matrices with correlation structure. Journal of Theoretical Probability 14 no. 4, 1097–1110 (2001). 60. Rempala, G.A. The martingale decomposition and approximation theorems for a generalized permanent function. Demonstratio Mathematicae 33 no 2, 431–446 (2001).

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61. Derrig, R., Rempala, G.A., and Ostaszewski, K. Resampling Methods in Actuarial Science. Proceedings of the Casualty Actuarial Society 2000; vol 87, pp 322-364 62. Rempala, G.A.. and Gupta A.K Limiting behavior of elementary symmetric polynomials of increasing order. Random Operators and Stochastic Equations 8, no. 1, 39–50 (2000). 63. Rempala, G.A.. and Gupta A.K Some limit theorems for permanents of random matrices. Random Operators and Stochastic Equations 8, no. 4, 1–14 (2000). 64. Rempala, G.A. and Wesolowski, J Limiting behavior of random permanents. Statistics and Probability Letters 45, 149–158 (1999). 65. Rempala, G.A. and Gupta A.K. Weak limits of U-statistics of infinite order. Random Operators and Stochastic Equations 7, no. 1, 39–53 (1999). 66. Rempala, G.A. and Derrig, R. and Ostaszewski, K. ) Applications of Resampling Methods in Dynamic Financial Analysis Casualty Actuarial Society Forum May 1998 67. Rempala, G.A. SLLN for U-statistics of varying order. Statistics and Probability Letters 39, no. 4, 263–220 (1998). 68. Rempala, G.A. and Sz´ekely, G.J On estimation with elementary symmetric polynomials. Random Oper. Stochastic Equations 6, no. 1, 77–88 (1998). 69. Rempala, G.A. Asymptotic behavior of random permanents. Random Operators and Stochastic Equations 4, no. 1, 33–45 (1996). 70. Rempala, G.A. and Wesolowski, J. and Nguyen, T.T Non-Gaussian Measures with Gaussian Structure. Probab. Math. Statist. 16, no. 2, 287–298 (1996). 71. Rempala, G.A.and Seredynski, F Approach to optimal task allocation by a Boltzmann machine. Arch. Inform. Teor. Stosow. 4. no.1-4, 87–95 (1992).

Selected Manuscripts and Working Papers Grzegorz A. Rempala, Michal Seweryn, Leszek Ignatowicz Model for diversity analysis of antigen receptor repertoires. Manuscript, Mar 2010. Available at arXiv:1003.1066v1 Gheorghe Craciun, Casian Pantea and Grzegorz A. Rempala, Dimension reduction for inferring biochemical networks. Manuscript May 2009, available at arXiv:0902.4417v

Organization of Synergistic Activities Session on Statistical Inference for Constrained Stochastic Dynamical Systems, during 8-th International Applied Math Congress (jointly with Sebastian Kurtek); China National Convention Center, Beijing, August 8-12, 2015 http://www.iciam2015.cn

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Research and Collaboration Forum for Southeastern Researchers in Mathematical Modeling of Biological Systems at the Cancer Research Center, Georgia Health Sciences University, Augusta, GA Mar 27–28, 2012. https://neyman.cph.ohio-state. edu/miniconference/MiniConference-2012-scheduled.html Mini Workshop On Statistical Methods for Biochemical Reaction Systems at Medical College of Georgia, Augusta, GA Dec 6–9, 2009. http://frg.georgiahealth.edu/ workshop Hot Topics Workshop on Stochastic Models for Intracellular Reaction Networks at the Institute for Mathematics and Its Applications, University of Minnesota, Minneapolis, MN May 11–13, 2008 (jointly with Tom Kurtz, Lea Popovic, and Ruth Williams) http://www.ima.umn.edu/2007-2008/SW5.11-13.08/ Workshop on Biosystems Modeling at Statistical and Applied Mathematical Sciences Institute (SAMSI), Mar 5–7, 2007 (jointly with Darren Wilkinson). http://www.samsi.info/workshop/... Mini Symposium on Computational Models in Molecular Medicine, Center for Genetics and Molecular Medicine, University of Louisville, Jan 5-6, 2007. Workshop on Modern Statistical Learning Methods in Engineering and Biomedical Sciences. University of Louisville, May 2-3, 2005. (jointly with Aly Farag). Statistical and Applied Mathematical Sciences Institute Summer Research Seminar Series, Research Triangle Park, NC. July-August 2004. Institute for Mathematics and Its Applications, Complex Systems Seminar Series, Minneapolis, MN, September, 2003–April 2004. (jointly with Tom Kurtz). Twenty Fifth Midwestern Probability Colloquium, Northwestern University, October 2003 (jointly with Salah Mohammed and Ofer Zeitouni). Session on Applied Probability and Actuarial Science, AMS Regional Meeting, Louisville, KY, March 1998.

Meeting Presentations/Invited Lectures VIII International Congress of Industrial and Applied Mathematics, Beijing, China, August, 2015. Micro and Macro Systems in Life Sciences, Bedlewo, Poland, June 2015. IX European Conference on Mathematical and Theoretical Biology, Gothenburg, Sweden, June 2014. Ordered Data Analysis, Models and Health Research Methods, Dallas, TX, March 2014. ´ VIII European Conference on Mathematical and Theoretical BIology, Krakow, Poland, June 2011. XI Probability Conference, B edlewo, Poland, May 2010.

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Workshop on Biomathematics and Biostatistics of Molecular Structures at the Banff International Research Station in Alberta, Canada, January 2010. AMS Sectional Meeting, Baylor University, Waco TX Session on Applied Algebra, October 2009. AMS Regional Meeting, North Carolina State University, Raleigh, NC, Session on Biochemical Dynamics, Apr, 2009. Conference on Discrete Models in Systems Biology Statistical and Applied Math Institute. December, 2008. Program on Algebraic Methods in Systems Biology and Statistics, Opening Workshop. Statistical and Applied Math Institute September, 2008. Focused Research Group Meeting: Stochastic Models in Intracellular Reactions, UC San Diego, CA, January 2008. Workshop on chemical kinetic models UT-ORNL-KBRIN Bioinformatics Summit, Paris Landing, KY, April 2007. Session on Random Matrices and Non-commutative Probability, AMS Regional Meeting, Miami University, Athens, OH, April 2007. Workshop on Biosystems Modeling, Statistical and Applied Mathematical Sciences Institute (SAMSI), March 2007. Conference on Stochastic Models for Cell Biology, Cornell University, Ithaca, NY, Apr 2006. Statistical and Applied Mathematical Sciences Institute Workshop on National Defense and Homeland Security. Syndromic Surveillance Panel. Research Triangle Park, NC September, 2005. World Risk and Insurance Economics Congress, Salt Lake City, UT, August 2005. Workshop on Modern Statistical Learning Methods in Engineering and Biomedical Sciences. Louisville, KY May 2005. Casualty Actuarial Society Loss Reserve Seminar. San Antonio Sheraton, San Antonio, TX, March 2003. 8th International Vilnius Conference on Probability Theory and Mathematical Statistics Giedyminus Technical University, Vilnius, Lithuania June 2002 27th Conference on Stochastic Processes and their Applications Center for Mathematical Sciences, Cambridge University U.K. July 2001 2000 Casualty Actuarial Society Annual Meeting. JW Marriot, Washington, D.C. November, 2000. VI International Conference on Probability Poraj, Poland. July 2000. IV National Conference of New Researchers in Probability and Statistics. Johns Hopkins University, Baltimore, MD, August 1999. Bootstrap Workshop. Massachusetts Insurance Bureau, Boston MA, May 1999.

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International Mathematical Congress. Berlin University of Technology, Berlin, Germany, August 1998 International Indian Statistical Institute Meeting. Mc Master University, Hamilton, Canada, October 1998. Casualty Actuarial Society Loss Reserve Seminar. Philadelphia Marriot, Philadelphia, PA, September 1998 Casualty Actuarial Society Dynamical Financial Analysis Seminar. Boston Sheraton, Boston, MA, July 1998 AMS Sectional Meeting. University of Louisville, Louisville, KY, March 1998. III National Conference of New Researchers in Probability and Statistics. University of Wyoming, Laramie, WY, July 1997

Other Invited Talks, Colloquia, etc. ´ Department of Mathematical and Natural Sciences, Stefan Wyszynski University, Warsaw Poland, June 2015. Centro de Investigacin en Matemticas, Guanajuato, Gto, M´exico, December 2014 Department of Statistics, Ohio State University, Columbus, OH, Nov 2014. Department of Mathematics, Notre Dame University, March 2014 ´ Department of Mathematical and Natural Sciences, Stefan Wyszynski University, Warsaw Poland, June 2012. Department of Statistics, University of South Carolina, Columbia, SC, Nov 2011. Department of Biostatistics, Ohio State University, Columbus, OH, Oct 2011. Mathematical Biosciences Institute, Ohio State University, Columbus, OH, Sep 2011. Department of Biostatistics, University of Louisville, Louisville, KY, May 2011. Department of Biochemistry, University of Georgia, Athens, GA, May 2011. Department of Applied Mathematics, Rutgers University, New Brunswick, NJ, April 2011. Department of Mathematics, Princeton University, Princeton, NJ, April 2011. Department of Statistics, University of Georgia, Athens, GA, Sep 2010. Deptartament of Mathematics, Warsaw Technical University, Warsaw Poland, June 2010. Department of Mathematics, Georgia Southern University, Statesboro, GA, Apr 2010. Department of Mathematics, University of Louisville, Louisville, KY, Apr 2010. Department of Biostatistics, Emory University, Atlanta, GA, Mar 2010. Institute of Bioinformatics, University of Georgia, Athens, GA, Mar 2010. Department of Mathematical Sciences, Clemson University, Clemson SC, Dec 2009.

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G. Rempala - CV

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Department of Mathematics, University of Texas at Dallas, Dallas TX, October 2009. ´ Department of Mathematical and Biological Sciences, Stefan Wyszynski University, Warsaw, Poland, June, 2009. Bioinformatics Research and Development Lab, Parco Tecnologico, Localit`a Piscinamanna, 09010 Pula, Sardinia - Italy, July 2007 Department of Mathematics, University of South Florida, Tampa, FL Feb, 2007. Department of Statistics, University of South Carolina, Columbia, SC January 2007. Statistics Department, NC State University, Durham, November, 2006; Statistical and Applied Mathematical Sciences Institute, Durham, NC, January 2006. Department of Applied Mathematics, Warsaw Technical University, Warsaw, Poland, January 2005, September 2005. Computer Vision and Image Processing Laboratory, Department of Electrical Engineering, UofL, October 2004. National Institute of Statistical Science, Durham, NC July 2004. Statistical and Applied Mathematical Sciences Institute, Durham, NC, June 2004. Department of Mathematics, University of Minnesota, Minneapolis, MN, April 2004. Institute for Mathematics and Its Applications, Minneapolis, MN, January 2004. Department of Mathematics, University of Wisconsin, Milwaukee, WI, November 2003. Department of Statistics, Vilnius Technical University, Vilnius, Lithuania, July 2002. Department of Mathematics, Rose-Hulman IT, Terra-Haute, IN. March 2002. Department of Mathematics, Boise State University, Boise, ID. March 2002. Department of Statistics, Stanford University, Palo Alto CA. July 2001. Department of Mathematics, University of Paris, Paris, France. July 2001. Department of Mathematics, Illinois State University, Normal, IL. April 2001, 2002. Department of Mathematics, University of Cincinnati, Cincinnati OH. September 2000. Institute of Mathematics, Polish Academy of Sciences, Warsaw, Poland. June 2000. Department of Statistics, University of Kentucky, Lexington, KY. September 1999, April 2003. Center for Mathematical Sciences, University of Wisconsin-Madison, Madison, WI. July 1999, 2000. Department of Mathematics, Warsaw University of Technology, Warsaw, Poland. June 1999,2001. Department of Statistics, Texas A&M University, College Stations, TX. March 1999. Department of Mathematics, University of Texas at Dallas, Dallas, TX. March 1999.

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July 22, 2016

Mentoring and Advising Post doctoral mentor for 1. Anil Devarapu 2007-2010 (currently at Albany State University) 2. Boseung Choi 2009-2010 (currently at Gyeongsan University ) 3. Iwona Pawlikowska 2008-2010 (currently at St Jude Hospital) 4. Marc Birtwistle 2011-2012 (currently at Mount Sinai Medical Center) 5. Jaejik Kim 2010-2012 (currently at GHSU Biostatistics) ´ 6. Michal Seweryn 2011-2013 (currently at the University of Łodz) 7. Maciej Pietrzak 2013- (OSU) PhD thesis advisor for 1. Michal Czajkowski Joinpoint regression models in cohort mortality analysis (Spring 2007). Currently at Boston Insurance. 2. Ayman S. El-Baz Stochastic Modeling for Segmentation of Multi-modal Images (Fall 2006). Co-advisor with Aly Farag, CVIP Lab, University of Louisville. Currently at COM, University of Louisville. 3. Refaat M. Mohamed Statistical Learning for Dimensionality-Independent Density Estimation in Pattern Recognition (Fall, 2005). Co-advisor with Aly Farag, CVIP Lab, University of Louisville. Currently at Western Kentucky University. 4. Joshua Green Statistical Models of Antigen Receptor Data (Spring 2013). Currently at Georgia Health Sciences University. 5. Daniel Linder Genetic Models via Jump Markov Processes (Summer 2013). Currently at Georgia Southern University Master’s thesis advisor for 1. Caleb Bastian Altered Developmental Programming Of The Mouse Mammary Gland In Female Offspring Following Perinatal Dietary Exposures: A Systems-Biology Perspective (Fall 2008) 2. Fadden Holden Binomial P-Spline Models in Analyzing Cohort Mortality Patterns (Fall 2007) 3. K. Szatszneider. Parametric Bootstrap in Mortality Tables (Fall 2003)

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July 22, 2016

4. E. Vertuli Inhibin B levels and testicular injuries in the cohort of male chemical workers (Spring 2002) 5. Rafal Komendarczyk. Multivariate Cuzick’s tests (Fall 1999)

Refereeing and Reviewing Referee for: Annals of Applied Statistics, Brazilian Journal of Probability and Statistics, IET Systems Biology, Journal of Applied Analysis and Applications, Metrika, Journal of Nonparametric Statistics, British Journal of Mathematical and Statistical Psychology, Sankhya, Journal of American Statistical Association, Journal of Statistical Planning and Inference, Statistics and Probability Letters, Applied Mathematics Letters, Journal of Stochastic Analysis and Applications, SIAM, CRC Press, CAS, Random Operators and Stochastic Equations, Sequential Analysis, CAS Proceedings, Encyclopedia of Actuarial Sciences, Communications in Statistics: Theory and Methods, TEST. Reviewer and scientific panels member for: National Science Foundation (Division of Mathematical Sciences), National Security Agency (Statistics), National Institutes of Health (F32 Fellowship Awards, Kidney, Nutrition, Obesity and Diabetes Study Section, Biomedical Engineering Study Section) Editorial board member for: Frontiers in Systems Biology.

Courses Taught ⇤

indicates a graduate course

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G. Rempala - CV

Course: Stochastic Epidemic Models⇤ Statistical Methods for Molecular Biology⇤ Algebraic Statistical Models in Comparative Genomics Math Models in Systems Biology⇤ Adv. Probability Models⇤ Introduction to Statistical Learning⇤ Generalized Linear Models⇤ Adv. Mathematical Statistics⇤ Adv. Probability Theory⇤ Introduction to Probability Theory⇤ Elementary Statistics Sampling Techniques⇤ Statistical Data Analysis⇤ Nonparametric Statistics⇤ Mathematical Statistics I Calculus II Differential Equations

July 22, 2016

Time taught: Spring 15 Spring 13 Fall 07 Fall 06, Spring 11 Fall 99, Spring06 Fall 08, Fall 10, Spring 14 Fall 09 Spring 99,Spring 03, Spring 09,10 Fall 98, Fall 02 Spring 05 Fall 97-Spring 07 (large lecture) Spring 98 Summer 97, Fall 00, Spring 01 Fall 97 Fall 96 Spring 97 Fall 96, Spring 97

Statistical Consulting Client: Seagal et al. Legal Offices, Louisville, KY American Chemistry Council Poly One Corporation Casualty Actuarial Society Epic Actuaries Inc Massachusetts Auto-Insurers Bureau National Institute for Alcohol Abuse and Alcoholism OPAL Consulting LLC

Last activity: December 1998 July 2001 Summer 2002 March 2003 May 2003 Feb. 2004 Feb. 2004 ongoing

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Statistical and Mathematical Modeling Software Development Divo CRAN R-library for calculating diversity of and the overlap between frequency distributions using Renyi entropy-based measures. Available from CRAN repository (jointly with Michal Seweryn and Maciej Pietrzak) BioReactor web-based java software for simulating and analyzing stochastic models of chemical kinetics. Under grant DMS0941113 from National Science Foundation. Beta version currently available at https://neyman.cph.ohio-state.edu/BioReactor. html (jointly with Ivan Werner and Jaejik Kim). LJR a set of R-language routines for analyzing change point regression models with binomial responses. Available from CRAN repository. Under research contract with National Cancer Institute, 2007 (jointly with Ryan Gill and Michal Czajkowski). STaS 1.0 and 1.1 SAS EIS add-on software, for non-parametric analysis of the Detailed Claims Database of the Massachusetts Insurance Bureau. Under contract with the Massachusetts Insurance Bureau, Boston, MA 1999. ReBeCCA soft. SAS EIS add-on software for bootstrap power calculations in CC epidemiological studies, based on Cuzick’s and Van-Elteren’s tests. Under contract with the Division of Occupational Epidemiology, University of Louisville, School of Medicine, Louisville, KY 2000 (jointly with Rafal Komendarczyk).

Current Research Areas Computational genomics and bioinformatics. Mathematical models of chemical reaction networks, multiple matchings and alignment problems. Stochastic elongation and adsorption models, oligo-probe hybridization reaction. Gene expressions data, microarray and deep sequencing analysis. Empirical Bayesian methods. Strong and weak experiment-wide error control. Multiple testing. Applications to cancer modeling. Mathematical statistics. Nonparametric estimation theory. Empirical likelihood methods. Subsampling and resampling plans. Block and circular bootstrap methods. Nonparametric regression and machine learning. Time series-based inferences. Nonparametric time series theory. Mathematical epidemiology. Epidemiological studies and occupational surveillance. Stochastic models of epidemics. Bio-surveillance and scan-type statistics. Casecontrol studies. Resampling plans. Ordinal scale exposure measurements and exposure misclassification problems. Multiple exposure. Multivariate rank tests methods for exposure models. Change-point logistic regression. Classical probability theory. Functionals on random matrices. Symmetric statistics of infinite order, permanent decompositions and martingale representations, resampling and subsampling plans. U -processes and their strong approximations.

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July 22, 2016

Stochastic processes. Stochastic differential equations and time series analysis with applications to financial mathematics and molecular biology, especially cash flow models and bio-chemical reaction models. Diffusion approximations of empirical processes and related non parametric modeling methods.

Current and Recent Collaborators Wolfgang Sadee (OSU), Tom Kurtz, Gheorge Craciun and Casian Pantea (University of Wisconsin), Lea Popovic (Concordia Univ.), Yuhong Yang (Univ. of Minnesota), Kenneth Ramos, (University of Louisville, Biochem.), Tom Knudsen (EPA Comp. Toxicology), Michal Czajkowski, Ryan Gill (University of Louisville, Math), Rafal Komendarczyk, Sudesh Srivastav (Tulane University), Richard Levis (University of Kentucky), Stephen Looney (Georgia Health Sciences Univ.), Jacek Wesolowski (Warsaw Inst. of Technology), Michael Baron (Univ. of Texas at Dallas), Richard Derrig (Automobile Insurers Bureau of Massachusetts, Opal Consulting), Doug Darling (University of Louisville, Cell Biology), Ted Kalbfleisch (University of Louisville Biochem. and Center for Genetics), John Cowell, Leszek Ignatowicz, Piotr Kraj, Jaejik Kim (Georgia Health Sciences Univ), Pawel Hitczenko (Drexel Univ.)

Other Info 2009-2013 Assistant Scout Master, Boy Scouts of America (Troop 8, Augusta GA) 2013– Member, Music Ministry for the Polish Catholic Community, Columbus, OH

References

Available upon request