CURRICULUM VITAE William Joseph Evans, Ph.D., FACSM, FACN Vice President, Head Muscle Metabolism Discovery Performance Unit GlaxoSmithKline Research Triangle Park, NC [email protected] Adjunct Professor of Medicine, Division of Geriatrics Senior Research Fellow Duke University Medical Center Durham, NC Fellow of the American College of Sports Medicine Fellow of the American College of Nutrition Member: American Society for Nutritional Sciences American Physiological Society Gerontological Society of America Endocrine Society of America Honorary Member (awarded in 1998): American Dietetic Association Home Address: 23120 Umstead, Chapel Hill, NC 27517 EDUCATION: BA l972 Zoology, University of North Carolina at Chapel Hill MS l976 Biology, Ball State University, Human Performance Laboratory Ph.D. l980 Human BioEnergetics, Ball State University, Human Performance Laboratory PROFESSIONAL EXPERIENCE: 1997- 2009 Director, Nutrition, Metabolism, and Exercise Laboratory Jane and Ed Warmack Chair in Nutritional Longevity Donald W. Reynolds Institute on Aging Professor of Geriatric Medicine, Professor of Physiology and Biophysics, and Professor of Nutrition, University of Arkansas for Medical Sciences, Little Rock, Arkansas 1993-1997 Director, Noll Physiological Research Center; Professor of Nutrition and Applied Physiology; The Pennsylvania State University 1982-1993 Chief of the Human Physiology Laboratory and Senior Scientist at the USDA Human Nutrition Research Center on Aging, Tufts University Professor of Nutrition, Tufts University School of Nutrition Professor of Physiology, Tufts University School of Medicine l978 - l982 Assistant Professor of Health Sciences, Director, Exercise Biochemistry Laboratory, Sargent College, Boston University. HONORS, COMMITTEES, STUDY SECTIONS: 2012 Ad-hoc member, Skeletal muscle and exercise physiology study section, NIH 2010Associate Editor, Journal of Cachexia, Sarcopenia and Muscle (new journal – volume 1, number 1: September, 2010) 2008 Founding Director: “Society on Cachexia and Wasting Disorders” (SCWD) 2008 - 2009 Chairman, UAMS Institutional Review Board 2008 Editorial Board, Journal of Clinical Endocrinology and Metabolism

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2007 2006 -

2006 -

2005 – 2008 2005 2005: 2005: 2005: 2005:

2005 20052004: 2003 2001- 2005 2001 2000 2000-2003 2000 1999-2003 1999-2001 1998 1997-2001 1996, 1997

Editorial Board, Journal of the American Medical Directors Association Member, Organizing Committee, Cachexia Consensus Conference, Washington, DC, December 13, 14, International Cachexia Conference, Tampa, FL, 2007, Consensus Meeting of Diagnostic Criteria for Cachexia (with FDA), 2008, International Cachexia Conference, Barcelona, 2009. Chair, Working Group on Functional Outcome Measures for Clinical Trials: Joint meetings with NIA, FDA, and Scientists engage in aging research to arrive at a consensus on appropriate outcome measures and potential indications in geriatrics. Member, Neurological, Aging, and Musculoskeletal Epidemiology Study Section (NAME), NIH Invited testimony to the US Senate Special Committee on Aging on Nutrition and Physical Activity in Elderly People, June 30, Washington, DC, “Saving Dollars, Saving Lives: The Importance of Prevention in Curing Medicare” Chairman, Organizing Committee for NIH sponsored conference: “Nutritional Needs of Elderly People in Long-Term Care”, May 2005, Washington, D.C. Organizing Committee: Consensus Conference on Operational Issues in Clinical Trials of Anabolic Therapies (FDA and NIH) August, 2005, Washington, D.C. Member (and speaker) International Scientific Committee, 3rd Cachexia Conference, Dec. 8-10, Rome, Italy. Member Expert Panel (Jointly sponsored by Centers for Medicare and Medicaid Services and National Center for Medical Rehabilitation Research) to develop a research agenda for inpatient rehabilitation and to review the 75% rule. Member and Chair, NIH Clinical Nutrition Research Unit Special Study Section. Editorial Board, Journal of Nutrition, Health, and Aging Member, Organizing Committee for “Cachexia in Aging and Cancer Conference”, December 4 & 5, Chicago, IL. Calloway Visiting Professor in Nutrition, U Cal, Berkeley, Dept. of Nutrition Member, Epidemiology of Clinical Disorders and Aging Study Section, NIH Visiting Tisdale Professor, University of Vermont, College of Medicine Chairman, Organizing Committee for the 11th International Conference on the Biochemistry of Exercise: “Molecular Aspects of Physical Activity and Aging” Member, (Chairman, 2002-2003) Dept. Of Veterans Affairs Merit Review Subcommittee for Aging and Clinical Geriatrics Ad-hoc member NIH General Clinical Research Center Study Section Editorial Board Journal of the American Medical Directors Association (JAMDA) and Caring for the Ages. Board of Advisors, National Space Biomedical Research Institute Team Leader, Nutrition, Physical Fitness, and Rapid Rehabilitation Honorary Member, American Dietetic Association Member: Life Sciences Advisory Subcommittee of the Life and Microgravity Sciences and Applications Committee, Universities Space Research Association, NASA Scientific advisor, ACTG - AIDS Clinical Trial Group

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1997-2001 1995, 97, 98 1995 1995-2002 1995-2003 1995 1994 1994 1993 1992-1993 1992 - 1999 1992- 1996 1991-1995 1991-1993 1991-1997 1991-1997 1990 1990-1993 1990 1989 - 1992 1988 - 1993 1983 - 1993 1982 l980 - 1993 l978 - l980

Expert Advisory Panel: Nutrition and Health for Older Americans initiative, American Dietetic Association Site review team for review of General Clinical Research Centers, General Medicine Institute, NIH Ad Hoc member, Nutrition Study Section, National Institutes of Health National Scientific Advisory Council, American Federation for Aging Research Human Research Facility Science Working Group, for National Aeronautics and Space Administration and Universities Space Research Association US Olympic Committee -- Nutritional Supplementation Subcommittee Reviewer of the Geriatrics Program of the National Institute on Aging Organizing Committee for National Institute on Aging Sarcopenia Workshop Ad-Hoc NIH study section, "Pathologic effects of impaired myocardial function in older persons" American Institute of Biological Sciences Physiology and Countermeasures Review Panel for the National Aeronautics and Space Administration National Institute on Aging study section "Claude Pepper Centers for Independent Living Editorial board, Journal of Gerontology: Medical Sciences Member, Biological and Clinical Aging Review Committee (Study Section), National Institute on Aging. Clinical Research Center Advisory Committee, MIT Editorial Board, Journal of Aging and Physical Activity Associate Editor, Medicine and Science in Sports and Exercise. Ad Hoc member, Respiration & Applied Physiology Study Section, National Institutes of Health. Member, Editorial Board, International Journal of Sports Nutrition. Member, Task Force on Rehabilitation Medicine Research, NIH Member, Committee on Military Nutrition Research, Food and Nutrition Board, National Academy of Sciences. Member, Tufts University Human Investigation Review Committee. Editorial Advisory Board, Tufts University Diet & Nutrition Letter. Organizing Committee, Fifth International Symposium on the Biochemistry of Exercise, Boston, MA. Consultant, Boston Bruins Hockey Team, 1986-1992 New England Patriots Summers, Research Physiologist, US Army Research Institute of Environmental Medicine, Natick, MA, Grade-GS-l2.

Reviewer for the following journals: Acta Physiologica Scandinavica, Journal of Applied Physiology, JAMA, American Journal of Physiology, Medicine and Science in Sports and Exercise, Archives of Physical Medicine and Rehabilitation, International Journal of Sports Medicine, American Journal of Clinical Nutrition, Journal of Clinical Endocrinology and Metabolism, Journals of Gerontology, Journal of the American Geriatric Society, Journal of Clinical Investigation, Journal of Physiology (London), The Lancet, New England Journal of Medicine

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PUBLICATIONS H index > 64 (64 papers with > 64 citations): SA Stimpson, SM Turner, LG Clifton, JC Poole, HA Mohammed, TW Shearer, GM Waitt, LL Hagerty, KS Remlinger, MK Hellerstein, and WJ Evans, Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-d3) dilution in rats, J Appl Physiol, 112:1940-1948 2012.

Evans, CJ, CF Chiou, KA Fitzgerald, WJ Evans, BR Ferrrell, W Dale, LP Fried, SR Gandra, B Dennee-Sommers, DL Patrick, Development of a new patient-reported outcome measure in sarcopenia. J Am Med Dir Assoc 12(3):226-33, 2011. Epub 2010 Nov 25. Fiser, WM, NP Hays, SC Rogers, O Kajkenova, AE Williams, CM Evans, and WJ Evans, Energetics of walking in elderly people: factors related to gait speed, J. Gerontol. Med Sci. 65: 1332-1337, 2010. Coker, RH, RH Williams, SE. Yeo, PM Kortebein, DL Bodenner, PA Kern, and WJ Evans, Exercise Training versus Caloric Restriction: Impact on Hepatic and Peripheral Insulin Resistance, J Clin Endocrinol Metab, 94: 4256-4266, 2009. Ferrando, AA, D Paddon-Jones, NP Hays, P Kortebein, O Ronsen, RH Williams, A McComb, TB Symons, RR Wolfe, and WJ Evans, EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly, Clin Nutr , 29:18-23, 2010 Hays, NP, H Kim, O Kajkenova, AM Wells, and WJ Evans, Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women, Journal of the American Dietetic Association 109: 1082-1087, 2009. Coker, R, R Williams, S Yeo, P Kortebein, D Bodener, P Kern, and W Evans, Influence of exercise intensity on abdominal fat and adiponectin in elderly adults, Metabolic Syndrome and Related Disorders, 7: 363-368, 2009. Kortebein, P, TB Symons, A Ferrando, D Paddon-Jones, O Ronsen MD, E Protas,, S Conger, J Lombeida, R Wolfe, WJ Evans, Functional impact of ten days bed rest in healthy older adults, J. Gerontol. Med Sci. 63: 1076-1081, 2008. Turley, KR, JR Bland, and WJ Evans, Effects of different doses of caffeine on exercise responses in young children, Med Sci Sports Exerc 40: 871- 878, 2008. Kortebein, P, A Ferrando, J Lombeida, RR Wolfe, and WJ Evans, Effect of ten days of bed rest on skeletal muscle in older adults JAMA 297: 1772-1774, 2007. Yeo, SE, NP Hays, RA Dennis, P Kortebein, DH Sullivan, WJ Evans, and RH Coker, Fat distribution and glucose metabolism in older, obese men and women J. Gerontol. 62A: 13931401, 2007. Coker, RH, NP Hays, RH Williams, AD Brown, DH Sullivan, and WJ Evans. Exercise-induced changes in insulin action are reliant on glycogen metabolism in elderly adults, Medicine & Science in Sports & Exercise 38: 433-438, 2006. Hays, NP, RD Starling, DH Sullivan, JD Fluckey, RH Coker, WJ Evans, Comparison of insulin sensitivity assessment indices with euglcemic-hyperinsulinemic clamp data following a dietary and exercise intervention in older adults, Metabolism: Clinical and Experimental 55: 525-532, 2006. Hays, NP, RD Starling, DH. Sullivan,JD Fluckey, RH Coker, RH Williams, and WJ Evans Effects of an ad libitum high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women, J. Gerontol A Biol Sci Med Sc. 61: 299304, 2006. Uc, EY, LK. Struck, RL. Rodnitzky, B Zimmerman, J Dobson, and WJ. Evans, Predictors of Weight Loss in Parkinson’s Disease, Movement Disorders, 21: 930-936, 2006.

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Sullivan DH, PK Roberson, LE Johnson, O Bishara, WJ Evans, ES Smith, and JA Price: Effects of muscle strength training and testosterone in frail elderly males. Medicine & Science in Sports & Exercise, 37(10):1664-1672, 2005. Evans, WJ, DP Kotler, S Staszewski, GE Griffin, J Isgaard, JM Gertner, F O’Brien and E Svanberg, Effect of recombinant human growth hormone on exercise capacity in patients with HIV-associated wasting on highly active antiretroviral therapy: The AIDS Reader, 15(6):301-3, 306-8, 310, 314, 2005. Urso, ML, MA Fiatarone Singh, W Ding, WJ Evans, AC Cosmas, and TG Manfredi, Exercise training effects on skeletal muscle plasticity and IGF-1 receptors in frail elders, AGE 27: 117-125, 2005. Bodenner, DL, M Medhi, WJ Evans, DH Sullivan, H Liu, CP Lambert. Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men. American Journal of Geriatric Pharmacotherapy 3: 160-167, 2005. Hays, NP, RD Starling, X Liu, DH Sullivan, TA Trappe, JD Fluckey, and WJ Evans, Effects of an ad libitum, low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial, Archives of Internal Medicine 164: 210-217, 2004. Dennis RA, TA Trappe, P Simpson,C Carroll,H Huang,R Nagarajan,E Bearden,C Gurley, GW Duff, WJ Evans, K Kornman, CA Peterson. Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exercise. J Physiol. 560(Pt 3): 617-626, 2004 Lambert CP, MG Flynn, DH Sullivan, and WJ Evans, Effects of megestrol acetate on circulating interleukin-15 and interleukin-18 concentration in healthy elderly men, J. Gerontol A Biol Sci Med Sci 59: 855-858, 2004. Hughes, VA, R Roubenoff, M Wood, WR Frontera, WJ Evans, and MA Fiatarone Singh, Anthropometric assessment of 10-y changes in body composition in the elderly, Am. J. Clin. Nutr. 80: 475-482, 2004. Kruskall LJ, WW Campbell, WJ Evans. The Yale Physical Activity Survey for older adults: Predictions in the energy expenditure due to physical activity.J Am Diet Assoc.;104(8):12511257, 2004 Lambert, CP, R. Lee Archer, JA Carrithers, WJ Fink, WJ Evans and T.A. Trappe. Influence of creatine monohydrate on muscle metabolites and intense exercise capacity in individuals with multiple sclerosis. Archives of Physical Medicine and Rehabilitation: 84:1206-1210, 2003. Kuiack, SL, WW Campbell, and WJ Evans, A structured resistive training program improves muscle strength and power in elderly persons with dementia, Activities, Adaptation and Aging, 28 35-47, 2003. Kruskall L.J., W.W. Campbell, and W.J. Evans. The Atwater energy equivalents overestimate metabolizable energy intake in older humans: results from a 96-day strictly controlled feeding study. J. Nutr. 133:2581-2584, 2003 Krishnan R.K., W.J. Evans, and J.P. Kirwan. Glucose clearance is delayed after hyperglycemia in healthy elderly men. J. Nutr. 133:2363-2366., 2003. Peterson, J.M., T.A. Trappe, E. Mylona, F. White, C.P. Lambert, WJ Evans, F.X. Pizza. Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise. Med. Sci. Sports and Exer. 35:892-896, 2003. Uc EY, CP Lambert, SI Harik, RL Rodnitzky, and WJ Evans, Albuterol improves response to levodopa and increases skeletal muscle mass in patients with fluctuating Parkinson's disease, Clinical Neuropharmacology.25: 207-212, 2003.

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Lambert CP, D Sullivan, and WJ Evans, Megestrol acetate induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement., J Gerontol A Biol Sci Med Sci., 58A: 644-647, 2003. Lambert CP, D Sullivan, and WJ Evans, Effects of Testosterone Replacement and/or Resistance Training on Interleukin 6, Tumor Necrosis Factor Alpha, and Leptin in Elderly Men ingesting Megestrol Acetate: A Randomized Controlled Trial J Gerontol A Biol Sci Med Sci. 58A: 165-170, 2003. Krishnan, RK, WJ Evans, and JP Kirwan, Impaired Substrate Oxidation in Healthy Elderly Men After Eccentric Exercise, J Appl Physiol 94: 716-723, 2003. Lambert, CP, L Archer, and WJ Evans, Body composition in ambulatory women with multiple sclerosis, Arch Phys Med Rehabil, 83: 1559-1561, 2002. Porter, MM, ME Nelson, MAF Singh, JE Layne, CM Morganti, I Trice, CD Economos, R Roubenoff, WJ Evans, Effects of long-term resistance training and detraining on strength and physical activity in older women, Journal of Aging and Physical Activity, 10: 260-270, 2002. Ziegler, P, R Sharp, V Hughes, W Evans, CS Khoo, Nutritional status of teenage female competitive figure skaters, J. Am. Diet. Assoc. 102: 374-379, 2002. Campbell, WW, LJ Joseph, RA Anderson, SL Davey, J Hinton, WJ Evans Effects of resistive training and chromium picolinate on body composition and skeletal muscle size in older women, Int J Sport Nutr Exerc Metab, 12: 125-135, 2002 Campbell WW, TA Trappe, AC Jozsi, LJ Kruskall, RR Wolfe, WJ Evans Dietary protein adequacy and lower body versus whole body resistive training in older humans. J Physiol (London) 542(Pt 2):631-42, 2002. Campbell WW, LJ Kruskall, WJ Evans Lower body versus whole body resistive exercise training and energy requirements of older men and women. Metabolism 51(8):989-97, 2002. Lambert, CP, D Sullivan, S Freeling, DM Linquist, and WJ Evans, Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trial Journal of Clinical Endocrinology and Metabolism. 87: 2100-2106, 2002. Kirwan, JP, RK Krishnan, JA Weaver, LF Del Agula, and WJ Evans, Human aging is associated with altered TNFa production during hyperglycemia and hyperinsulinemia. Am. J. Physiol. Endocrinol. Metab. 281: E1137 – E1143, 2001. Trappe, TA, JA Carrithers, F White, CP Lambert, WJ Evans, RA Dennis, Titin and nebulin content in human skeletal muscle following eccentric resistance exercise, Muscle Nerve, 25: 289-292, 2002. Hughes, VA, WR Frontera, R Roubenoff, WJ Evans, and MA Fiatarone Singh Longitudinal changes in body composition in older men and women: role of body weight change and physical activity Am J Clin Nutr 76: 473-481, 2002 Lambert CP, RL Archer, and WJ Evans.Muscle strength and fatigue during isokinetic exercise in individuals with multiple sclerosis. Med Sci Sports Exerc. 33:1613-1619, 2001. Campbell WW,RE Ostlund Jr, LJ Joseph, PA Farrell, WJ Evans Relationships of plasma Cpeptide and gender to the urinary excretion of inositols in older people. Horm Metab Res. 33(1):44-51, 2001 Morse, MH, MD Haub, WJ Evans, and WW Campbell, Protein requirement of elderly women: nitrogen balance responses to three levels of protein intake. J Gerontol A Biol Sci Med Sci;56 724-730, 2001 Trappe, T. A., F White, CP Lambert, M Hellerstein, and WJ Evans, Influence of ibuprofen and acetaminophen on skeletal muscle protein synthesis following eccentric resistance exercise, Am. J. Physiol. Endocrinol. Metab 282, E542-E550, 2002

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Trappe, TA, JD Fluckey, F White, CP Lambert, and WJ Evans, Skeletal muscle PGF2a and PGE2 in response to eccentric resistance exercise: Influence of ibuprofen and acetaminophen, Journal of Clinical Endocrinology and Metabolism, 86: 5067 – 5070, 2001. Hughes, VA, WR Frontera, M. Wood, WJ Evans, GE Dallal, R Roubenoff, and MA Fiatarone Singh, Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity , and health, J. Gerontol. Biol. Sciences, 56: B209- B218, 2001. Murray-Kolb LE, JL Beard, LJ Joseph, SL Davey, WJ Evans, and WWCampbell. Resistance training affects iron status in older men and women. Int J Sport Nutr Exerc Metab.11: 287298, 2001. Thomas. DR, W Ashman, JE Morley, and WJ Evans, Nutritional management in long-term care: Development of a clinical guideline, J. Gerontol: Med. Sci. 55A: M725-M734, 2000. Kirwan, JP, D Cyr-Campbell, WW Campbell, J Scheiber, and WJ Evans, Effects of moderate and high glycemic index meals on metabolism and exercise performance, Metabolism 50: 849-855, 2001. Kirwan, JP, DJO O'Gorman, D Cyr-Campbell, WW Campbell, KE Yarasheski, and WJ Evans, Effects of a moderate glycemic meal on exercise duration and substrate utilization, Med. Sci. Sport and Exerc, 33: 1517-1523, 2001 Joseph, LJO, TA Trappe, PA Farrell, WW Campbell, KE Yarasheski, CP Lambert, and WJ Evans, Effects of short-term, moderate weight loss and resistance training on insulin action in postmenopausal women Diabetes Care 24: 1863-1869, 2001. Campbell, WW, TA Trappe, RR Wolfe, and WJ Evans, The Recommended Dietary Allowance for protein may not be adequate for older people to maintain skeletal muscle, J. Gerontol.: Med. Sci. 56A: M373-M380, 2001. Jozsi, AC, WJ Evans, EE Dupont-Versteegden, TA Trappe, WW Campbell, and CA Peterson, Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise, Mech. Aging Dev. 120:45-56, 2000. Casteñeda, C., PL Gordon, RA Fielding, WJ Evans, and MC Crim, Marginal protein intake results in reduced plasma IGF-I levels and skeletal muscle fiber atrophy in elderly women, Journal of Nutrition, Health, and Aging 4: 85-90, 2000. Fiatarone Singh, MA, MA Bernstein, ND Ryan, EF O’Neill, KM Clements, and WJ Evans, The effects of oral nutritional supplements on habitual dietary quality and quantity in frail elders, Journal of Nutrition, Health and Aging, 4: 5-12, 2000. Bernstein, MA, KL Tucker, ND Ryan, EF O’Neill, KM Clements, ME Nelson, WJ Evans, and MA Fiatarone Singh, Higher dietary diversity is associated with better nutritional status in frail elders, J. Am. Diet. Assoc. 102: 1096-1104, 2002. Frontera, WR, VA Hughes, R Fielding, WJ Evans, and R Roubenoff, Aging of skeletal muscle: a 12-yr longitudinal study, J. Appl. Physiol. 88: 1321-1327, 2000. Fiatarone Singh, MA, W Ding, TJ Manfredi, G Solares, EF O’Neill, KM Clements, ND Ryan, RA Fielding, and WJ Evans, Insulin-like grow factor I in skeletal muscle after weight-lifting exercise in frail elders, Am. J. Physiol. 277: E135-E143, 1999. Campbell, WW, ML Barton Jr, D Cyr-Campbell, SL Davey, JL Beard, G Parise, WJ Evans, Effects of an omnivorous diet compared with a lactoovovegetarian diet on resistance-training-induced changes in body composition and skeletal muscle in older men, Am. J. Clin. Nutr., 70: 10321039, 1999 Jozsi, AC, WW Campbell, L Joseph, S Davey, and WJ Evans, Strength and power changes with resistance training in older and younger people, J. Gerontol. Med. Sci. 54: M591-M596, 1999. Kraemer, WJ, K Hakkinen, RU Newton, BC Nindl , JS Volek, M McCormick, LA Gotshalk, SE Gordon, SJ Fleck, WW Campbell, M Putukian, and WJ Evans, Effects of heavy-resistance

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training on hormonal response patterns in younger vs. older men, J. Appl. Physiol. 87: 982-992, 1999. Joseph, LJO, SL Davey, WJ Evans, and WW Campbell, Differential effect of resistance training on body composition and lipoprotein-lipid profile in older men and women, Metabolism 48: 14741480, 1999. Joseph, LJO, PA Farrell, SL Davey, WJ Evans, and WW Campbell, Effect of resistance training with or without chromium picolinate supplementation on glucose metabolism in older men and women, Metabolism , 48: 546-553, 1999 Campbell, WW, LJ Joseph, SL Davey, D Cyr-Campbell, RA Anderson, and WJ Evans, Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men, J. Appl. Physiol., 86: 29-39, 1999. Krishnan, RK, JM Hernandez, DL Williamson, DJ O’Gorman, WJ Evans, and JP Kirwan, Agerelated differences in the pancreatic b-cell response to hyperglycemia following eccentric exercise, Am. J. Phys. 275: E463-E470, 1998 Campbell, WW, JL Beard, LJ Joseph, SL Davey, and WJ Evans, Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes, Am. J. Clin Nutr. 66: 944-949, 1997 Kirwan, JP, D O’Gorman, and WJ Evans, A moderate glycemic meal before endurance exercise can enhance performance, J. Appl. Physiol. 84: 53-59, 1998. Hakkinen, K, RU Newton, SE Gordon M McCormick, JS Volek, BC Nindl, LA Gotshalk, WW Campbell, WJ Evans, A Hakkinen, BJ Humphries, and WJ Kraemer, Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and older men, J Gerontol A Biol Sci Med Sci. 53(6):B415-B423, 1998 Campbell, WW, D Cyr-Campbell, JA Weaver, and WJ Evans, Energy requirements for long-term weight maintenance in older women, Metabolism, 46: 884-889, 1997. Meydani, M, RA Fielding, JG Cannon, JB Blumberg, and WJ Evans, Muscle uptake of vitamin E and its association with muscle fiber type, J. Nutr. Biochem.. 8: 74-78, 1997. Fielding, RA, WR Frontera, VA Hughes, EC Fisher, and WJ Evans, The reproducibility of the Bruce protocol exercise test for the determination of aerobic capacity in older women, Med. Sci. Sports Exerc., 29: 1109-1113, 1997. Schuit AJ, EG Schouten, TP Miles, WJ Evans, WH Saris, FJ Kok, The effect of six months training on weight, body fatness and serum lipids in apparently healthy elderly Dutch men and women., Int J Obes Relat Metab Disord ; 22(9): 847-853, 1998. Fluckey, JD, TC Vary, LS Jefferson, WJ Evans, PA Farrell, Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age, J. Gerontol: Biological Sciences, 51A: B323-B330, 1996. Hagerman, FC, RA Fielding, MA Fiatarone, JA Gault, DT Kirkendall, KE Ragg, and WJ Evans, A 20-yr longitudinal study of Olympic oarsman Med. Sci. Sports Exerc., 28: 1150-1156, 1996. Nelson, ME, MA Fiatarone, JE Layne, I Trice, CD Economos, R Ma, RN Pierson, and WJ Evans, Analysis of body composition techniques and models in detecting compositional change in soft tissue with strength training, Am. J. Clin. Nutr. 63: 678-686, 1996. Roberts, SB, P Fuss, GE Dallal, GE Atkinson , WJ Evans, LJ Joseph, MA Fiatarone, AS Greenberg, VR Young, Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men, J. Gerontol. (Biol. Sci.) 51A: B148-B157, 1996. Hughes, VA, MA Fiatarone, RA Fielding, CM Ferrara, D Elahi, and WJ Evans, Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance, Am. J. Clin. Nutr. 62: 426-433, 1995.

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Campbell, WW, MC Crim, VR Young, LJ Joseph, and WJ Evans, Effects of resistance training and dietary protein intake of protein metabolism in older adults, Am. J. Physiol. 268: E1143-E1153, 1995. Morganti, CM, ME Nelson, MA Fiatarone, GE Dallal, CD Economos, BM Crawford, WJ Evans, Strength improvements with 1 year of progressive resistance training in older women, Med. Sci. Sport Exerc. 27: 906-912, 1995. Nelson, ME, MA Fiatarone, CM Morganti, I Trice, RA Greenberg, and WJ Evans, Effects of highintensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial, JAMA 272: 1909-1914, 1994. Fiatarone MA, EF O'Neill, N Doyle ,KM Clements, SB Roberts,JJ Kehayias ,LA Lipsitz, WJ Evans The Boston FICSIT study: The effects of resistance training and nutritional supplementation on physical frailty in the oldest old. J Am Geriatr Soc 1993;41:333-337. Roberts, SB, P Fuss, MB Heyman WJ Evans R Tsay H Rasmussen M Fiatarone J Cortiella, GE Dallal, and VR Young, Impaired control of food intake and energy regulation in elderly men, JAMA 272: 1601-1606, 1994. Fiatarone, MA, EF O'Neill, N Doyle, KM Clements, GR Solares, SB Roberts, JJ Kehayias, LA Lipsitz, and WJ Evans, Exercise training and nutritional supplementation for physical frailty in very elderly people, N. Engl. J. Med. 330: 1769-1775, 1994. Bathalon, GP, VA Hughes,, WW Campbell, MA Fiatarone, and WJ Evans, Can military prediction equations accurately determine compliance with military body fat standards? Med. Sci. Sports Exerc. 27: 1079-1085, 1995. Castañeda, C, JM Charnley, WJ Evans, MC Crim, Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response, Am. J. Clin. Nutr. 62: 30-39, 1995 Castañeda, C, GG Dolnikowski, GE Dallal, WJ Evans, MC Crim, Protein turnover and energy metabolism of elderly women fed a low-protein diet, Am. J. Clin. Nutr. 62: 40-48, 1995. Cannon, JG, MA Fiatarone, M Meydani, L. Scott, JB Blumberg, WJ Evans, Aging and dietary modulation of elastase and interleukin-1b secretion, Am. J. Physiol. 268: R208-R213, 1995 Cannon, JG, MA Fiatarone, RA Fielding, and WJ Evans, Aging and stress-induced changes in complement activation and neutrophil mobilization, J. Appl. Phyiol. 76: 2616-2620, 1994. Campbell, WW, MC Crim, VR Young, and WJ Evans, Increased energy requirements and body composition with resistance training in older adults, Am. J. Clin. Nutr. 60: 167-175, 1994. Campbell, WW, MC Crim, GE Dallal, VR Young, and WJ Evans, Increased protein requirements in the elderly: new data and retrospective reassessments, Am. J. Clin. Nutr. 60: 501-509, 1994. Hughes, VA, WR Frontera, GE Dallal, KJ Lutz, EC Fisher, and WJ Evans, Muscle strength and body composition: associations with bone density in older subjects, Med. Sci Sports Exerc. 27: 967-974, 1995 Hughes, VA, MA Fiatarone, CM Ferrara, JR McNamara, JM Charnley, WJ Evans, Lipoprotein response to exercise training and a low fat diet in older subjects with glucose intolerance, Am. J. Clin. Nutr. 59: 820-826, 1994. Meydani, M, WJ Evans, G Handelman, L Biddle, RA Fielding, SN Meydani, J Burrill, MA Fiatarone, JB Blumberg, and JG Cannon, Protective effect of vitamin E on exercise-induced oxidative damage in young and old adults, Am. J. Physiol. 264: R992-R998, 1993 Roubenoff, R and WJ Evans, Exercise and lean weight, Nutrition Reviews, 51: 25-26, 1993 McArthur, JW, BA Turnbull, J Pehrson, M Bauman, K Henley, A Turner, WJ Evans, BA Bullen, and GS Skrinar, Nalmefene enhances LH secretion in a proportion of oligo-amenorrheic athletes, Acta Endocrinologica, 128: 325-333, 1993 Calezel, CM, VR Young, WJ Evans, SB Roberts, Effect of fasting and feeding on measurement of carbon dioxide production using doubly labeled water, J. Appl. Physiol. 74: 1824-1829, 1993.

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McCully,K, RA Fielding WJ Evans, JS Liegh Jr., and JD Posner, Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles, J Appl. Physiol. 75: 813-819, 1993. Fielding, RA, TJ Manfredi, W Ding, MA Fiatarone, WJ Evans, JG Cannon, Acute phase response in exercise. III. Neutrophil and IL-1b accumulation in skeletal muscle, Am. J. Physiol, 265: R166-R172, 1993. Hughes, VA, MA Fiatarone, RA Fielding, BB Kahn, CM Ferrara, P Shepherd, EC Fisher, RR Wolfe, D Elahi and WJ Evans, Exercise increases muscle GLUT 4 levels and insulin in subjects with impaired glucose tolerance, Am. J. Physiol. 264: E855-E862, 1993. Hughes, VA and WJ Evans, Effect of aging on body fat, J. Am. Geriatr. Soc. 41: 1274-1275, 1993. Frontera, WR, VA Hughes, WJ Evans, Reliability of isokinetic muscle strength testing in 45 to 78 year old men and women, Arch. Phys. Med. Rehab. 74: 1181-1185, 1993. Roberts, SB, VR Young, PJ Fuss, MB Heyman, MA Fiatarone, T Clemmey, GE Dallal, J Corteilla and WJ Evans, What are the dietary energy needs of adults? Int. J. Obesity, 16: 969-976, 1992. Nelson, ME and WJ Evans, Macronutrients and anthropometrics, In Nutrition in the Elderly: The Boston Nutritional Status Survey, Edited by SC Hartz, RM Russell, and IR Rosenberg, Eldrid Smith-Gordon, Publishers, pages 55-65, 1992. Forman DE, WJ Manning. R Hauser, EV Gervino, WJ Evans, JY Wei, Enhanced left ventricular diastolic filling associated with long-term endurance training J. Gerontol. 47: M56-58, 1992 Bassey, EJ, MA Fiatarone, EF O'Neil, M Kelley, WJ Evans and LA Lipsitz, Leg extensor power and functional performance in very old men and women, Clin Sci 82: 321-327, 1992 Meredith, CN, WR Frontera, KP O'Reilly and WJ Evans. Body composition in elderly men: effect of dietary modification during strength training J Am Geriatr Soc 40: 155-162, 1992 Nelson, ME, EC Fisher, FA Dilmanian, GE Dallal and WJ Evans. A one-year walking program and increased dietary calcium in postmenopausal women: Effects on bone. Am J Clin Nutr. 53: 1304-1311, 1991. Reichsman, F, SP Scordilis, PM Clarkson, and WJ Evans, Muscle protein changes following eccentric exercise in humans, Eur. J. Appl. Physiol., 62: 245-250, 1991. Roberts, SB, MB Heyman, WJ Evans, PJ Fuss and VR Young. Dietary energy requirements of young adult men, determine using the doubly labeled water method. Am J Clin Nutr 54:499-505, 1991. Fielding, RA. CN Meredith, KP O'Reilly, WR Frontera, JG Cannon and WJ Evans. Protein metabolism in young and old men: enhanced myofibrillar protein breakdown following eccentric exercise. J Appl Physiol 71: 674-679, 1991. Manfredi, TS, RA Fielding, KP O'Reilly, CN Meredith, Ho Yong Lee and WJ Evans. Serum creatine kinase activity and exercise-induced muscle damage in older men. Med Sci Sports and Exer 23: 1028-1034, 1991. Frontera, WR, VA Hughes and WJ Evans. A cross sectional study of upper and lower extremity muscle strength in 45-78 year old men and women. J Appl Physiol 71: 644650, 1991. Cannon, JG, SN Meydani, RA Fielding, MA Fiatarone, M Meydani, M Farhangmehr, SF Orencole, JB Blumberg and WJ Evans. The acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis, Am J Physiol 260: R1235-R1240, 1991. Fiatarone, MA, EC Marks, ND Ryan, CN Meredith, LA Lipsitz and WJ Evans. High intensity strength training in nonagenarians. JAMA 263:3029-3034, 1990. Stauber, WT, PM Clarkson, VK Fritz and WJ Evans. Extracellular matrix disruption and pain after eccentric muscle action. J Appl Physiol 69: 868-874, 1990.

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Cannon, JG, SF Orencole, RA Fielding, M Meydani, SN Meydani, MA Fiatarone, JB Blumberg and WJ Evans. The acute phase response in exercise: The interaction of age and vitamin E on neutrophils and muscle enzyme release. Am J Physiol 259:R1214-1219, 1990. Frontera, WR, CN Meredith, KP O'Reilly and WJ Evans. Strength training and determinants of VO2 max in older men. J Appl Physiol 68(1):329-333, 1990. Roberts, SB, FD Morrow, WJ Evans, DC Shepard, GE Dallal, CN Meredith and VR Young. Use of p-aminobenzoic acid to monitor compliance with prescribed dietary regimens during metabolic balance studies in man. Am J Clin Nutr 51:485-488, 1990. Roberts, SB, VR Young, PJ Fuss, MA Fiatarone, B Richard, H Rasmussen, D Wagner, LJ Joseph, E Holehouse, and WJ Evans. Energy expenditure and subsequent nutrient intakes in overfed young men. Am J Physiol 259(28): R461-R469, 1990. Knapik, J, CN Meredith, B Jones, RA Fielding, VR Young and WJ Evans. Influence of exercise during fasting on leucine metabolism in young men. J Appl Physiol 70(1):43-47, 1990. Peachey SE, GS Skrinar, SE Leeman, J Pehrson, WJ Evans and BA Bullen. Effect of acute exercise on plasma neurotensin levels. Peptides 10(4): 753-756, 1989. Lamon-Fava, S, EC Fisher, ME Nelson, WJ Evans, JS Millar, JM Ordovas, EJ Schaefer, Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins. J. Clin. Endocrinol. Metab. 68: 17-21, 1989. Cannon, JG, RA Fielding, MA Fiatarone, SF Orencole, CA Dinarello and WJ Evans. Increased interleukin 1 in human skeletal muscle after exercise. Am J Physiol 26(2): R451-R455, 1989. Meredith, CN, MJ Zackin, WR Frontera and WJ Evans. Dietary protein requirements and protein metabolism in endurance-trained men. J Appl Physiol 66(6):2850-2856, 1989. Nelson, ME, CN Meredith, B Dawson-Hughes and WJ Evans. Hormone and bone mineral status in endurance trained and sedentary postmenopausal women. J Clin Endo and Metab 66:927933, 1988. Clark, N, ME Nelson and WJ Evans, Nutrition education for elite female runners. Phys Sports Med 16:124-136, 1988. Frontera, WR, CN Meredith, KP O'Reilly, HG Knuttgen and WJ Evans. Strength conditioning in older men: Skeletal muscle function and mass. J Appl Physiol 64:1038-1044, 1988. Meredith, CN, WR Frontera, EC Fisher, VA Hughes, JC Herland, J Edwards and WJ Evans. Peripheral effects of endurance training in young and old subjects. J Appl Physiol 66(6):28442849, 1989. Knapik, JJ, BH Jones, CN Meredith and WJ Evans. Influence of a 3.5 day fast on physical performance. Eur J Appl Physiol 56: 428-432, 1987. Meredith, CN, MJ, Zackin, WR Frontera and WJ Evans. Body composition and aerobic capacity in endurance trained men. Med Sci Sports Exercise 19:557-563, 1987. O'Reilly, KP, MJ Worhol, RA Fielding, WR Frontera, CN Meredith and WJ Evans. Eccentric exercise-induced muscle damage impairs muscle glycogen repletion. J Appl Physiol 63(1):252256, 1987. Evans, WJ Exercise related skeletal muscle damage. Physician and Sports Medicine, 15:88-105, 1987. Ribiero, JP, VA Hughes, RA Fielding, W Holden, WJ Evans and HG Knuttgen. Metabolic and ventilatory responses to steady state exercise relative to lactate thresholds. Eur J Appl Physiol 55:215-221, 1986. Fielding, RA, WJ Evans, VA Hughes, LL Moldawer and BR Bistrian. The effects of high intensity exercise on muscle and plasma levels of alpha- ketoiscaproic acid. Eur J Appl Physiol 55:482485, 1986. Nelson, ME, EC Fisher, PD Catsos, CN Meredith, RN Turksoy and WJ Evans. Diet and bone health in amenorrheic runners. Am J Clin Nutr 43:910-916, 1986.

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Evans, WJ, CN Meredith, JG Cannon, CA Dinarello, WR Frontera, VA Hughes, BH Jones and HG Knuttgen. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol 61:1864-1868, 1986. Fisher, EC, ME Nelson, WR Frontera, RN Turksoy and WJ Evans. Bone mineral content, gonadotropic and estrogenic hormone levels in amenorrheic runners. J Clin Endo & Metab 62 (6):1232-1236, 1986. Cannon, JG, CA Dinarello, WJ Evans, VA Hughes and CN Meredith. The initiation of an acute phase response to exercise: Mechanisms contributing to increased interleukin 1 production. J Appl Physiol 61:1869-1877, 1986. Young, A J, Evans, WJ, Fisher, EC Sharp, RL Costill, DL Maher, JT Skeletal muscle metabolism of sea-level natives following short-term high-altitude residence, Eur J Appl Physiol 52: 463-466, 1984. Warhol, MJ, AJ Siegel, WJ Evans and LM Silverman. Skeletal muscle injury and repair in marathon runners after competition. Am J Pathol 118:331-339, 1985. Istfan, N, E Murray, M Janghorrbani, WJ Evans and VR Young. The nutritional value of a soy protein concentrate (STAPRO-3200) for long-term protein nutritional maintenance in young men. Am J Clin. Nutri. 113:2524-2534, 1983. Evans, WJ, EC Fisher, RA Hoerr and VR Young. Protein metabolism and endurance exercise. Phys Sports Med 11(7):63-72, 1983. Evans, WJ, JF Patton, EC Fisher and HG Knuttgen. Muscle metabolism during high intensity eccentric exercise. Biochemistry of Exercise, Vol. 13, Human Kinetics Publishers, Inc., Champaign, IL, pp.225-228, 1983. Knapik, JJ, CN Meredith, BH Jones, L Suek, VR Young and WJ Evans. Influence of fasting on carbohydrate and fat metabolism during rest and exercise in men. J Appl Physiol 64:19231929, 1988 Fisher, EC, WJ Evans, SD Phinney, GL Blackburn, BR Bistrian and VR Young. Changes in skeletal muscle metabolism induced by a eucaloric ketogenic diet. Biochemistry of Exercise Vol. 13, Human Kinetics Publishers, Inc., Champaign, IL, pp.497-501, 1983. Knapik, JJ, BH Jones, MM Toner, WL Daniels and WJ Evans. Influence of caffeine on serum substrate changes during running in trained and untrained individuals. Biochemistry of Exercise, Vol. 13, Human Kinetics Publishers, Inc., Champaign, IL, pp. 514-519, 1983. Ciriello, VM, WL Holden and WJ Evans. The effects of two isokinetic training regimens on muscle strength and fiber composition. Biochemistry of Exercise, Vol. 13, Human Kinetics Publishers, Inc., Champaign, IL, pp. 787-793, 1983. Cadarette, BS, L Levine, CL Berube, BM Posner and WJ Evans. Effects of varied dosages of caffeine on endurance exercise to fatigue. Biochemistry of Exercise, Vol. 13, Human Kinetics Publishers, Inc., Champaign, IL, pp. 871-876, 1983. Siegel, A, WJ Evans and L Silverman. Elevated skeletal muscle creatinine kinase MB isoenzyme levels in marathon runners. JAMA 250:2835-2837, 1983. Levine, L, WJ Evans, BS Cadarette, EC Fisher and BA Bullen. Effects of fructose and glucose ingestion on muscle glycogen use during submaximal exercise. J Appl Physiol Respirat Environ Exercise Physiol 55(6):1767-1771, 1983. Skrinar, GS, WJ Evans, LJ Ornstein and DA Brown. Glycogen utilization in wheel-chair dependent athletes. Internat J Sports Med 3(4):215-219, 1982. Young, AJ, WJ Evans, A Cymerman, KB Pandolf, JJ Knapik and JT Maher. Sparing effect of chronic high-altitude exposure on muscle glycogen utilization during exercise. J Appl Physiol Respirat Environ. Exercise Physiol 52(4):857-862, l982.

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Phinney, SD, BR Bistrian, WJ Evans, EV Gervino and GL Blackburn. The human metabolic response to chronic ketosis without caloric restriction. Preservation of submaximal exercise capability with reduced carbohydrate oxidation. Metabolism 32(8):769-776, 1983. Evans, WJ and JL Ivy. Effects of testosterone propionate on skeletal muscle of hindlimb immobilized rats. J Appl Physiol Respirat Environ Exercise Physiol 52(6):1643-1647, l982. Evans, WJ , SD Phinney and VR Young. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exer 14(l):l0l-l02, l982. Levine, L, WJ Evans, KB Pandolf and FR Winsmann. Prolonged self-paced hard work comparing trained and untrained men. Ergonomics 25(5):393-400, l982. Evans, WJ, FR Winsmann, KB Pandolf and RF Goldman. Self-paced hard work comparing men and women Ergonomics 23:6l3-62l, l980. Evans, WJ, AS Bennett, DL Costill and WJ Fink. Leg muscle metabolism in trained and untrained men. Research Quarterly 50:350-360, l979. Costill, DL, E Coyle, G Dalsky, WJ Evans and WJ Fink. Effects of elevated plasma FFA and insulin on muscle glycogen usage during exercise. J Appl Physiol 43:695-699, l977. Costill, DL, J Daniels, WJ Evans, WJ Fink, G Krahenbuhl and B Saltin. Skeletal muscle enzymes and fiber composition in male and female track athletes. J Appl Physiol 40(2):l49-l54, l976. INVITED REVIEWS W. J. Evans, Muscle and Bone Interactions: Effects of Sarcopenia, In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition, Editor, Clifford Rosen, John Wiley & Sons, Inc, In Press, 2012. C. Cooper, W. Dere, W. J. Evans, J. A. Kanis, R. Rizzoli, A. A. Sayer, C. C. Sieber, J.-M. Kaufman, G. Abellan van Kan, S. Boonen, J. Adachi, B. Mitlak, Y. Tsouderos, Y. Rolland, J.-Y. L. Reginster, Frailty and sarcopenia: definitions and outcome parameters, Osteoporosis Int, 2012 Jan 31. [Epub ahead of print]. Abbatecola A. M. , G. Paolisso, P. Fattoretti, W. J. Evans, V. Fiore, L. Dicioccio, F. Lattanzio Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction, J Nutr Health Aging . 15(10):890-895, 2011. Dodson S., V. E. Baracos, A. Jatoi, W. J. Evans, D. Cella, J. T. Dalton, M. S. Steiner, Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies, Annu Rev Med, 18;62: 265-279, 2011 Fearon K., W. J. Evans, S. D. Anker.Myopenia-a new universal term for muscle wasting, J Cachexia Sarcopenia Muscle. 2(1):1-3, 2011 Fielding R. A., B. Vellas, W. J. Evans, S. Bhasin, J. E. Morley, A. B. Newman, G. Abellan van Kan, S. Andrieu, J. Bauer, D. Breuille, T. Cederholm, J. Chandler, C. De Meynard, L. Donini, T. Harris, A. Kannt, F. Keime Guibert, G. Onder, D. Papanicolaou, Y. Rolland, D. Rooks, C. Sieber, E. Souhami, S. Verlaan S, M. Zamboni Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia J Am Med Dir Assoc. 12:249-256, 2011. Epub 2011 Mar 4 Chumlea W. C., M. Cesarit, W. J. Evans, L. Ferrucci, R. A. Fielding, M. Pahor, S. Studenski, Vellas B. Sarcopenia: designing phase IIb trials: international working group on sarcopenia. J Nutr Health Aging.15(6):450-455, 2011 Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S, Cederholm T, Stewart Coats AJ, Cummings SR, Evans WJ, Fearon K, Ferrucci L, Fielding RA, Guralnik JM, Harris TB, Inui A, Kalantar-Zadeh K, Kirwan BA, Mantovani G, Muscaritoli M, Newman AB, Rossi-Fanelli F, Rosano GM, Roubenoff R, Schambelan M, Sokol GH, Storer TW, Vellas B, von Haehling S, Yeh SS, Anker SD; the Society on Sarcopenia, Cachexia and

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Wasting Disorders Trialist Workshop. Sarcopenia with Limited Mobility: An International Consensus. J Am Med Dir Assoc. 2011 Jun 2. [Epub ahead of print] Fearon, K., W. J. Evans, and SD Anker, Myopenia-a new universal term for muscle wasting J Cachex Sarcopenia Muscle; 2:1-3, 2011. Epub 2011 Mar 25 Evans, W.J., Drug Discovery and Development for Ageing: Opportunities and Challenges, Philosophical Transactions of the Royal Society 366: 113-119, 2011. Evans, W. J., Paolisso, G., A. M. Abbatecola, A. Corsonello, S. Bustacchini, F. Strollo, and F. Lattanzio, Frailty and muscle metabolism dysregulation in the elderly, Biogerontology 11: 527-536, 2010. Evans, W.J., Skeletal muscle loss: cachexia, sarcopenia, and inactivity, American Journal of Clinical Nutrition 91: 1123S-1127S, 2010. Morley, J.E., J.M. Argiles, W.J. Evans, S. Bhasin, D. Cella, N.E. Deutz, W. Doehner, K.C. Fearon, L. Ferrucci, M.K. Hellerstein, K. Kalantar-Zedeh, H. Lochs, N. MacDonald, K. Mulligan, M. Muscaritoli, P. Ponikowski, M.E. Poshauer, F. Rossi Fanelli, M. Schambelan, M.W. Schuster, S.D. Anker,Society for Sarcopenia, Cachexia, and Wasting Disease, Nutritional recommendations for the management of sarcopenia J Am Med Dir Assoc. 11:391-6, 2010. Morley J. E., S. D. Anker, and W. J. Evans Cachexia and aging: an update based on the Fourth International Cachexia Meeting. J Nutr Health Aging;13:47-55, 2009. Abbetecola, A. M., W. J. Evans, and G. Paolisso, Current perspectives in the use of PUFA for treatments of human diseases: Diabetes and PUFA supplements in older persons, Current Pharmaceutical Design 15: 4126-4134, 2009. Saris, W. H. M., S. B. Heymsfield, and W. J. Evans, Human brain evolution: food for thoughts, Current Opinion in Clinical Nutrition and Metabolic Care, 11: 683-685, 2008. Evans, W. J., J. E. Morley, S. D. Anker, and the cachexia consensus panel, Cachexia: A New Definition, Clinical Nutrition, 27: 793-799 2008. Evans, W. J. and the Working Group on Functional Outcome Measures for Clinical Trials, Indications, Labeling and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation between Aging Researchers and FDA Regulators, J. Gerontol.: Med. Sciences 64: 487-491, 2009. Evans, W. J. and the Working Group on Functional Outcome Measures for Clinical Trials, Functional outcomes for clinical trials in frail older persons. Time to be moving, J. Gerontol.: Med. Sciences, 63A: 160-165, 2008. Evans, W. J., The use of megestrol acetate to promote weight gain should be carefully weighed, invited editorial, J. Clin. Endocrinol. Metab. 92: 420-422, 2007. Hays, N.P. and W.J. Evans, Body composition and function in older people, International Journal of Body Composition Research, 4: 111-121, 2006. Evans, W. J. and C.P. Lambert, Physiological Basis of Fatigue, American Journal of Physical Medicine and Rehabilitation, 86: S29-S46, 2007. Evans, W. J., Strategies to prevent late-life dysfunction and chronic disease in elderly people, in Saving Dollars, Saving Lives: The Importance of Prevention in Curing Medicare, Hearing before the Special Committee on Aging, US Senate, U.S. Government Printing Office, Serial No. 10911, pp 37-42, 2006. Lambert, C.P., E. Y. Uc, and W.J. Evans, β2-adrentergic agonists increase skeletal muscle mass and strength in human disease states and models of muscle atrophy, In: Pharmacotherapy of Cachexia, CRC Press (Taylor & Francis), Boca Raton, Editors, KG Hofbauer, SD Anker, A Inui, and JR Nicholson, pp: 311-325 2006. Evans, W.J. and N.P. Hays, All calories are not equal, Archives of Internal Medicine, 165: 1069, 2005. Lambert, C.P. and W.J. Evans, Adaptations to aerobic and resistance exercise in the elderly, Reviews in Endocrine & Metabolic Disorders, 6: 137-143, 2005

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Evans, W.J., Protein nutrition, exercise, and aging. J. Am. Coll. Nutr., 23: 601S-609S, 2004. Lambert, C. P., L. L. Frank, and W. J. Evans, Macronutrient considerations for the sport of bodybuilding, Sports Medicine, 34: 317-327, 2004. Evans, W.J. , Exercise for successful aging, Broklehurst's Textbook of Geriatric Medicine and Gerontology 6th Edition, edited by RC Tallis and HM Fillit, Elsevier Science, Ltd, London, pp. 855-863, 2003. Lambert, C. P. and W. J. Evans, Effects of aging and resistance exercise on determinants of muscle strength, J. Amer. Aging Assoc., 25: 73-78, 2002. Evans, W. J. Effects of exercise on senescent muscle, Clinical Orthopaedics, Volume 403S, S211S230, 2002. Evans, W. J. Exercise as the standard of care for elderly people, J Gerontol A Biol Sci Med Sci, 57: M260-M261, 2002 Evans, W. J. Physical function in men and women with cancer: effects of anemia and conditioning, Oncology, 16 (supplement 10), 109-117, 2002. Evans, W. J. Protein Nutrition and Resistance Exercise, Can. J. Appl. Physiol., 26(Suppl): 142-153, 2001. Evans, W. J. and P. A. Farrell, The Aging Pancreas: Effects of age on insulin action and secretion, The Endocrine Pancreas and Regulation of Metabolism, Volume II, Handbook of Physiology, American Physiological Society, Oxford University Press, L. Jefferson and A. Cherrington, editors, Chapter 32, 2001. Drewnowski, A. and W. J. Evans (Co-Editors of Special Issue) Nutrition, Physical Activity, and Quality of Life in Older Adults: Summary, Journal of Gerontology: Medical Sciences, 56: 8994, 2001. Evans, W. J., Exercise and Aging, Handbook of Exercise in Diabetes, Ed. N. Ruderman, American Diabetes Association, Alexandria, pp. 567-587 2001. Evans, W. J., Vitamin E, vitamin C, and exercise, Am. J. Clin. Nutr. 72 (suppl.): 647S-652S, 2000. Evans W. J. and W. W. Campbell Exercise, ageing, and protein metabolism. Diabetes Nutr Metab.;13:108-112 2000. Evans, W. J., Exercise strategies should be designed to increase muscle power (invited editorial), J Gerontol. Med. Sciences, 55: M309-M310, 2000. Evans, W. J., Exercise for successful aging, in Exercise and Sport Science, Lippincott Williams & Wilkins, W. E. Garrett, Jr. And D. T. Kirkendall, editors, pp: 277-285, 1999. Pollock, M. L. and Evans, W. J., Resistance training for health and disease: introduction, Med. Sci. Sports Exerc., 1999, 31: 10-11. Evans W. J., Exercise and nutritional needs of elderly people: effects on muscle and bone.Gerodontology.15:15-24, 1998. Evans, W. J., Exercise guidelines for the elderly, Med. Sci. Sports Exerc., 1999, 31: 12-17. Mazzeo, R. S., Cavanagh, P., Evans, W. J., Fiatarone, M. A., Hagberg, J., McAuley, E., and Statzell, J., Exercise and physical activity for older adults: American College of Sports Medicine Position Stand, Med. Sci. Sports Exerc. 30: 992-1008, 1998 Evans, W. J., R. Roubenoff, and A. Shevitz, Exercise and the treatments of wasting: aging and human immunodeficiency virus infection, Semin. Oncol. 25 (suppl 6): 112-122, 1998 Evans, W. J., Exercise guidelines for elderly men and women, in Healthy Aging: Activity and Sports, Health Promotion Publications, G. Huber, editor, pp. 182-192, 1997. Evans, W. J. Functional and metabolic consequences of sarcopenia, J. Nutr. 127(suppl): 998S1003S, 1997. Fielding, R. A. and W. J. Evans, Aging and the acute phase response to exercise: Implications for the role of systemic factors on skeletal muscle protein turnover, Int. J. Sports Med., 18: S22-S27, 1997.

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Evans, W. J. and D. Cyr-Campbell, Nutrition, exercise and healthy aging, J. Am. Diet. Assoc. 97: 632-638 1997. Kraemer, W. J., S. J. Fleck, and W. J. Evans, Strength and power training, physiological mechanisms of adaptation, Exercise and Sports Sciences Reviews, Volume 24, J. O. Holloszy (ed.),Williams & Wilkins, publishers, pp. 363-399, 1996. Evans, W.J. , Effects of Aging and Exercise on Nutrition Needs of the Elderly, Nutrition Reviews, 54: S35-S39, 1996 Evans, W.J. , Reversing sarcopenia: How weight training can build strength and vitality, Geriatrics, 51: 46-53, 1996 Evans, W. J., Exercise, nutrition, and aging, In: Clinics in Geriatric Medicine: Nutrition, Aging, and Age-Dependent Diseases, Vol. 11 (4), D. A. Lipschitz (ed.), W. B. Saunders Co, Philadelphia, pp. 725-734, 1995. Evans, W. J., Exercise and Aging, In: The Health Professional's Guide to Diabetes and Exercise, N. Ruderman and J. Devlin (ed.), American Diabetes Association, pp. 223-233, 1995. Evans, W.J., Exercise in the prevention of age-associated changes in body composition and functional capacity, in Delaying the Onset of Late-Life Dysfunction, R.N. Butler and J.A. Brody (eds.), Springer Publishing Co., NY, pp. 35-53, 1995. Campbell, W.W. and W. J. Evans, Protein requirements of elderly people, Eur. J. Clin Nutr., Suppl. 1: S180-S185, 1996. Evans, W.J., What is sarcopenia?, J. Geront. 50A (Special Issue: Workshop in Sarcopenia): 5-8, 1995. Evans, W.J., Effects of exercise on body composition and functional capacity in the elderly, J. Geront.50A (Special Issue: Workshop in Sarcopenia): 5-8, 1995. Evans, W.J., Exercise, aging and protein metabolism, In: Protein-Energy Interactions, B. SchÜrch and N. Scrimshaw (eds.), UN International Dietary Energy Consultancy Group, Switzerland, 235-249, 1992. Evans, W. J., Sarcopenia: The age-related loss in skeletal muscle mass, In: Musculoskeletal SoftTissue Aging: Impact on Mobility, J. A. Buckwalter, V. M. Goldberg, and S. L-Y. Woo (eds.), American Academy of Orthopaedic Surgeons and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, pp. 217-229, 1993. Evans, W.J., Exercise and Protein Metabolism, In: World Review of Nutrition and Dietetics, Simopoulous, A.P., Pavlou, K.N. (eds) Karger, Basel, vol. 71: pp 21-33, 1993 Fiatarone, M. A. and W. J. Evans, The etiology and reversibility of muscle function in the aged J. Gerontology, 48: 77-83, 1993. Meydani, M. and W. J. Evans, Free radicals, exercise and aging, In: Free Radicals in Aging, B. P. Yu (ed.), CRC press, Inc., Boca Raton, pp. 183-203. 1993. Evans, W.J. and W.W. Campbell, Sarcopenia and age-related changes in body composition and functional capacity, J. Nutr., 123: 465-468, 1993. Roberts, SB, P Fuss, W.J. Evans, M.B. Heyman, and V.R. Young, Energy expenditure, aging and body composition, J. Nutr. 123: 474-480, 1993 Rogers, M. A. and W. J. Evans, Changes in skeletal muscle with aging: Effects of exercise training, Exercise and Sports Sciences Reviews, Volume 21, J. O. Holloszy (ed.),Williams & Wilkins, publishers, pp. 65-103, 1993. Evans, W. J., Exercise, Nutrition, and Aging, J. Nutr., 122: 796-801, 1992. Evans, W.J., Exercise and Muscle function in Frail Older Persons, In: Reducing Frailty and falls in Older Persons, R. Weindruch, E. Hadley, and M. Ory, Charles C. Thomas, Publisher, Springfield, IL, pp. 431-440, 1991. Evans, W.J. Muscle damage: nutritional considerations. Int. J. Sports Nutr. 3, 1991.

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Evans, W.J. and J.G. Cannon, The metabolic consequences of exercise-induced muscle damage, In: Exercise and Sports Sciences Reviews, Volume 19, J.O. Holloszy (ed.), Williams & Wilkins, publishers, pp. 99-126, 1991. Fiatarone, M.A., and W.J. Evans, Exercise in the oldest old, Topics in Geriataric Rehab., 5:63-77, 1990. Evans, W.J., and C.N. Meredith. The effects of physical activity on nutritional needs of the elderly. IN: Human Nutrition, edited by H.N. Munro Plenum Publishing Corporation, 1989. Fisher, E.C., M.E. Nelson, and W.J. Evans. Effect of diet and exercise on bone health. IN: Physical Activity, Aging and Sports: Scientific and Medical Aspects, Ed: R. Harris et al. Albany, NY, pp. 301-315, 1989. Evans, W.J. Exercise and muscle metabolism in the elderly. In: Bristol-Myers Symposia: Nutrition and Aging. S. Gershoff, M. Hutchinson, H. Munro (Eds.). Academic Press, Orlando, Fla., pp. 179-190, 1986. Frontera, W.R. and W.J. Evans. Exercise performance and endurance training in the elderly. Topics in Geriatric Rehab 2:17-32, 1986. Evans, W.J. and V.A. Hughes. Dietary carbohydrates and endurance exercise, Am. J. Clin. Nutr. 41:1146-1154, 1985. Hoerr, R. A., V. R. Young, and W. J. Evans. Protein metabolism and exercise. In: Diet and Exercise: Synergism in Health Maintenance, P. L. White and T. Mondeika (Eds.). American Medical Association, 49-63, 1982. Witzman, FA, D.L Costill, W. J. Evans and WJ Fink. Analytical Methods for the Measurement of Human Performance. Laboratory Manual printed by Ball State University, l978. BOOKS Evans, W. J. and G. Couzens, AstroFit, Simon & Schuster, Spring, 2002. Evans, W.J., I.R. Rosenberg, and J. Thompson. Biomarkers: The Ten Determinants of Aging You Can Control, Simon & Schuster, New York, May, 1991.