Current Update Chemotherapy in Breast Cancer DAAN KHAMBRI DIVISI BEDAH ONKOLOGI BAGIAN BEDAH FK-UNAND/RS DR.M.DJAMIL PADANG

Capecitabine Targeting Chemotherapy It targets Cancer Cells

Most patients prefer oral chemotherapy, providing efficacy is not compromised Patients (%) 100 Oral i.v.

80 60 40 20 0 Liu et al. (n=103)1

Borner et al. (n=31)2 1Liu 2Borner

G et al. J Clin Oncol 1997;15:110–15 M et al. Eur J Cancer 2002;38:349–58

TP is significantly more active in human tumour than healthy tissue Patients (n) Colorectal

115 115

Gastric

291 351

Breast

309 309

Liver (metastasis)

16 20

Healthy tissue *

Tumour tissue *

*

* 0

100

200

300

400

500

TP activity (µg 5-FU/mg protein/hour) *p