Creatinine-based estimates of GFR (egfr) are widely

Screening for Chronic Kidney Disease Complications in US Adults: Racial Implications of a Single GFR Threshold Hassan N. Ibrahim,* Changchun Wang,† Ar...
Author: Joella Sims
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Screening for Chronic Kidney Disease Complications in US Adults: Racial Implications of a Single GFR Threshold Hassan N. Ibrahim,* Changchun Wang,† Areef Ishani,*† Allan J. Collins,*† and Robert N. Foley*† *Department of Medicine, University of Minnesota, and †United States Renal Data System Coordinating Center, Minneapolis, Minnesota Background and objectives: An ideal and effective screening tool should perform equally across ethnic groups. The objective of this study was to determine whether the widely advocated creatinine-based estimated GFR (eGFR) threshold of 60 ml/min per 1.73 m2 identifies the typical metabolic abnormalities related to chronic kidney disease equally well in minority and nonminority adults. Design, setting, participants, & measurements: This objective was addressed using data for 8918 minority and nonminority adult participants in the National Health and Nutrition Examination Survey 2003 through 2006, which used stratified, multistage, probability sampling methods to assemble a nationwide probability sample of the noninstitutionalized population of the United States. Metabolic abnormalities including BP, potassium, hemoglobin, bicarbonate, uric acid, calcium, phosphorus, and parathyroid hormone were defined by fifth or 95th percentile values. Results: Among participants with eGFR