Singh et al

Journal of Drug Delivery & Therapeutics. 2015; 5(1):82-87

82

Available online on 15.01.2015 at http://jddtonline.info

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RESEARCH ARTICLE

COMPARATIVE STUDY OF HORMONAL AND NON-HORMONAL TREATMENTS FOR THE MANAGEMENT OF MENOPAUSAL SYMPTOMS 1

Singh Sujata, 2Dhasmana D C, 3Dutta Shaktibala, 4Gupta Vineeta,

1

Associate Professor, Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly 243 202, U.P., India 2

Professor, Department of Pharmacology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun -248140, U.K., India 3

Professor and Head, Department of Pharmacology, Shri Guru Ram Rai Institute of Medical & Health Sciences, Dehradun -248001, U.K., India 4

Professor, Department of Obstetrics & Gynaecology, Shri Guru Ram Rai Institute of Medical & Health Sciences, Dehradun -248001, U.K., India Received 24 Dec 2014; Review Completed 03 Jan 2015; Accepted 13 Jan 2015, Available online 15 Jan 2015

ABSTRACT Objective: This study was conducted with the objective of comparing safety and efficacy of hormonal treatment and nonhormonal alternatives for the management of menopausal symptoms. Materials and Methods: A total of 40 patients suffering from menopausal symptoms were recruited to the study protocol and were divided into 4 groups according to the treatment they received, with 10 patients in each group. Group A received conjugated estrogen and medroxy progesterone acetate, Group B received Tibolone, Group C received Isoflavone and Group D received Vitamin E. Efficacy of the treatment was evaluated by improvement in symptomatic score and safety of the treatment was assessed on the basis of adverse effects reported and relevant laboratory investigations. Results: Most of the symptoms were significantly improved in groups A and B (p< 0.01) while in groups C and D significant improvement was observed in hot flushes, sweating and insomnia (p