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286 Anitha A, Chennazhi KP, Nair SV, Jayakumar R. 5-Flourouracil loaded N, Ocarboxymethyl chitosan nanoparticles as an anticancer nanomedicine for breast cancer. J. Biomed. Nanotech., 8: 29-42; 2012. 287 Xiaowen S, Yumin D, Jianhong Y, Baozhong Z, Liping S. Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery. J. Appl. Polym. Sci., 100: 4689-4696; 2006. 288 Wang Y, Liu L, Weng J, Qiqing Z. Preparation and characterization of selfaggregated nanoparticles of cholesterol-modified-O-carboxymethyl chitosan conjugates. Carbohydr. Polym., 69: 597-606; 2007. 289 Wang YS, Jiang Q, Li RS, Liu LL, Zhang QQ, Wang YM, Zhao J. Selfassembled nano particles of cholesterol-modified O-carboxymethyl chitosan as a novel carrier for paclitaxel. Nanotechnology, 19:145101; 2008. 290 Sumanta KS, Sanjay KM, Susmita S, Tapas KM, Sudip KG, Panchanan P. In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery. J. Mater. Sci. Mater. Med., 21:1587-1597; 2010. 291 Chao F, Zhiguo W, Changqing J, Ming K, Xuan Z, Yang L, Xiaojie C, Xiguang C. Chitosan/O-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation. Int. J.Pharm., 457:158167; 2013. 292 Zhang X, Zhao J, Wen Y, Zhu C, Yang J, Yao F. Carboxymethyl chitosan-poly (amidoamine) dendrimer core-shell nanoparticles for intracellular lysozyme delivery. Carbohydr. Polym., 98: 1326-1334; 2013. 293 Guo H, Zhang D , Li C, Jia L, Liu G, Hao L, Zheng D, Shen J, Li T, Guo Y, Zhang

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295 Wang G, Jin L, Dong Y, Niu L, Liu Y, Ren F, Su X. Multifunctional [email protected] carboxymethyl chitosan drug

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312 Osuna B, Vauthier C, Farabollini A, Palmieri G F, Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly (isobutyl cyanoacrylate) coreshell nanoparticles. Biomaterials., 28: 2233-2243; 2007. 313 Foger F, Schmitz T, Bernkop-Schnurch A. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials., 27: 42504255; 2006. 314 Kafedjiiski K, Krauland A H, Hoffer M H, Bernkop-Schnurch A. Synthesis and in vitro evaluation of a novel thiolated chitosan. Biomaterials., 26: 819-826;2005. 315 Bernkop-Schnurch A. Thiomers: a new generation of mucoadhesive polymers. Adv. Drug Deliv. Rev., 57: 1569-1582; 2005. 316 Yin L, Ding J, He C, Cui L, Tang C, Yin C. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials., 30:5691-5700; 2009. 317 Kafedjiiski K, Hoffer M, Werle M, Bernkop-Schnurch A. Improved synthesis and

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322 Dunnhaupt S, Barthelmes J, Hombach J, Sakloetsakun D, Arkhipova V, Bernkop-Schnurch A. Distribution of thiolated mucoadhesive nanoparticles on intestinalmucosa. Int. J. Pharm., 408: 191-199; 2011. 323 Sajeesh S, Vauthier C, Gueutin C, Ponchel G, Sharma C P. Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery. Acta Biomater., 6: 3072-3080; 2010. 324 Martien R, Loretz B, Thaler M, Majzoob S, Bernkop-Schnurch A. Chitosanthioglycolic acid conjugate: an alternative carrier for oral nonviral gene delivery. J. Biomed. Mater. Res. A., 82: 1-9; 2007. 325 Wang X, Zheng C, Wu Z, Teng D, Zhang X, Wang Z, Li C, Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin. J. Biomed. Mater. Res. B Appl. Biomater., 88: 150-161; 2009. 326 Colo GD, Zambito Y, Zaino C. Polymeric enhancers of mucosal epithelial permeability:

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332 Anitha A, Deepa N, Chennazhi K P, Nair S V, Tamura H, Jayakumar R. Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications. Carbohydr. Polym., 83: 66-73; 2011. 333 Talaei F, Azizi E, Dinarvand R, Atyabi F. Thiolated chitosan nanoparticles as a delivery system for antisense therapy: evaluation against EGFR in T47D breast cancer cells. Int J Nanomedicine., 6:1963-1975; 2011. 334 Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov M A. Synthesis and in vitro evaluation of thiolated chitosan-dextran sulfate nanoparticles for the delivery of letrozole. J Pharm Educ Res., 1: 62-67; 2010. 335 Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov M A. Synthesis and characterization of biodegradable thiolated chitosan nanoparticles as targeted drug delivery system. J Nanomedic Nanotechnol., S4:001. doi:10.4172/21577439.S4001; 2011. 336 Wang X, Zheng C, Wu Z M, Teng DG, Zhang X, Wang Z, Li C X. Chitosan- AC nanoparticles as a vehicle for nasal absorption enhancement of insulin. J. Biomed. Mater.Res. B, Appl. Biomater., 88B: 150-161; 2009. 337 Saremi S, Dinarvand R, Kebriaeezadeh A, Ostad SN, Atyabi F. Enhanced oral delivery of docetaxel using thiolated chitosan nanoparticles: preparation, in vitro and in vivo studies. Bio Med Research International., Article ID 150478; 2013. 338 Jiang L, Li X, Liu L, Zhang Q. Thiolated chitosan-modified PLA-PCL-TPGS nanoparticles for oral chemotherapy of lung cancer. Nanoscale Res Lett., 2013, 8:66. doi: 10.1186/1556-276X-8-66. 339 Yousefpour P, Atyabi F, Dinarvand R, Vasheghani-Farahani. Preparation and comparison of chitosan nanoparticles with different degrees of glutathione thiolation. Daru., 9:367-375;2011. 340 Patel D, Naik S, Chuttani K, Mathur R, Mishra AK, Misra A. Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief. J Drug Target., 21:759-769; 2013.

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341 Shokrzadeh M, Ebrahimnejad P, Omidi M, Shadboorestan A, Zaalzar Z. Cytotoxity evaluation of docetaxel nanoparticles against HepG2 cell lines. JMUMS., 22:1-9; 2012. 342 Patel D, Naik S, Misra A. Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain. J Pharm Sci., 101: 690-706; 2012. 343 Alamdarnejad G1, Sharif A, Taranejoo S, Janmaleki M, Kalaee MR, Dadgar M, Khakpour M. Synthesis and

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350Bernkop-Schnurch A, Hornof M, Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int J Pharm., 260: 229-237; 2003. 351 Bernkop-Schnurch A, Kast CE, Guggi D. Review Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release., 93: 95-103; 2003. 352 Saremi S, Atyabi F, Akhlaghi S P, Ostad S N, Dinarvand R. Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation. Int J Nanomedicine., 6: 119-128; 2011. 353 Lee D-W, Shirley S A, Lockey R F, Mohapatra S S. Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline. Respir Res., 7: 2006.doi:10.1186/1465-9921-7-112. 354 Hayes E R. N, O-carboxymethyl chitosan and preparative method therefore. US patent US 4619995 A. (1986). 355 Chen S C, Wu Y C, Mi F L, Lin YH, Yu L C, Sung H W. A novel pH sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J Control Release., 96: 285-300; 2004. 356 Margit D H, Constantia E K, Bernkop-Schnurch A. In vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugates. Eur J Pharm Biopharm., 55: 185-190; 2003. 357 Bernkop-Schnurch A, Schwarz V, Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers. Pharm. Res., 16: 876-881; 1999. 358 Matsuhiro B, Presle L C, Saenz C, Urzua C C. Structural determination and chemical modifications of the polysaccharide from seeds of Prosopis chilensis Mol. (Stuntz). J. Chil. Chem. Soc., 51:813; 2006. 359 Devika R B, Varsha B P. Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: a technical note. AAPS Pharm Sci Tech., 7: E138E143; 2006.

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360 Gan Q, Wang T, Cochrane C, McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B., 44: 65-73; 2005. 361 Harboe M. A method for determination of hemoglobin in plasma by nearultraviolet spectrophotometry. Scand J Clin Lab Invest., 11:66-70; 1959. 362 Rao S B, Sharma C P. Use of chitosan as a biomaterial: studies on its safety and hemostatic potential. J. Biomed. Mater. Res., 34: 21-28; 1997. 363 Morris V B, Sharma C P. Folate mediated in vitro targeting of depolymerised trimethylated chitosan having arginine functionality. J Colloid Interface Sci., 348: 360-368; 2010. 364 Dobrovolskaia M A, Clogston J D, Neun B W, Hall J B, Patri A K, McNeil S E. Method for analysis of nanoparticle hemolytic properties in vitro. Nano Lett., 8: 2180-2187; 2008. 365 Hall J B, Dobrovolskaia M A, Patri A K, McNeil S E. Characterization of nanoparticles for therapeutics. Nanomedicine., 2: 789-803; 2007. 366 Harris SM, Jaweria T, Hamid AM, Rabia IY. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak J Pharm Sci., 19:119-124; 2006. 367 Wan CP, Letchford K, Jackson JK, Burt HM. The combined use of paclitaxelloaded nanoparticles with a low-molecular-weight copolymer inhibitor of Pglycoprotein to overcome drug resistance. Int J Nanomedicine., 8: 379-391; 2013. 368Wang T, Kievit FM, Veiseh O, Arami H, Stephen ZR, Fang C, Liu Y, Ellenbogen RG, Zhang M. Targeted cell uptake of a non internalizing antibody through conjugation to iron oxide nanoparticles in primary central nervous system lymphoma. World Neurosurg., 80:134-141; 2013. 369 Chou TC, Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul., 22: 27-55;1984. 370 Chou TC, Motzer RJ, Tong Y, Bosl GJ: Computerized quantitation of synergism and antagonism of Taxol, topotecan and cisplatin against human teratocarcinoma

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427 Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med., 351 :337-345; 2004. 428 Folprecht G, Lutz MP, Schoffski P, Seufferlein T, Nolting A, Pollert P, Kohne CH: Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol., 17: 450-456; 2006. 429 Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer R J.Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. 430 Alyssa M Master, Anirban Sen Gupta. EGF receptor-targeted nanocarriers for enhanced cancer treatment. Nanomedicine.,7:1895-1906; 2012. 431 Lee J J, Chu E. Sequencing of antiangiogenic agents in the treatment of metastatic colorectal cancer. Clin Colorectal Canc., 2014: Article In Press.

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