VOLUME 2 • ISSUE 6

DECEMBER 2011 NEWS FROM THE DEPARTMENT OF EPIDEMIOLOGY

MAILMAN SCHOOL OF PUBLIC HEALTH

COLUMBIA UNIVERSITY

Carotenoid supplements tied to increase in breast cancer deaths While the benefits of vitamin supplement use for breast cancer patients are unclear, some supplements may actually be harmful, according to a new study published in Cancer by lead author Dr. Heather Greenlee, Assistant Professor of Epidemiology and Medical Oncology (in Medicine), and colleagues. The researchers analyzed data from the Life After Cancer Epidemiology (LACE) prospective cohort study of 2,300 women with early-stage breast cancer, finding that those who regularly took either vitamins C or E supplements had a lower risk of cancer recurrence over five years compared to those who didn’t take them. However, women who regularly consumed a mix of carotenoids like vitamin A, beta-carotene, and lutein, were at greater risk of dying from breast cancer, and at risk of dying from any cause, when compared with those who didn’t take them. Moreover, much of the benefit associated with vitamins C and E could be explained by “healthy user bias,” which means that women who use dietary supplements generally have healthier lifestyles, according to Dr. Greenlee. Healthy user bias did not explain the findings found with mixed carotenoids. “Our paper adds to the growing body of literature suggesting that dietary supplements containing high doses of carotenoids may be harmful, and people should think twice before taking them,” Dr. Greenlee says. “Dietary supplement use is high among cancer patients and they need specific guidance on what is safe and effective.” Concerns have been raised that taking supplements with antioxidant properties, like carotenoids, vitamin E, vitamin C, selenium and zinc, during chemotherapy or

3 PUBLICATION HIGHLIGHTS 6 IN THE NEWS 7 BRIEF MENTIONS 8 AWARDS & GRANTS 9 PROFILES 12 MASTER’S PRACTICUM DAY 13 JOURNAL CLUB 14 PARTNER PROFILES 18 PIONEERS AMONG US 21 FACULTY ARTICLE BIBLIOGRAPHY

radiation can interfere with treatments. This could occur because the supplements may protect tumor cells from the “pro-oxidant” effects of cancer treatments. However, antioxidants cannot be assumed to uniformly act in a similar function, since they have different physiological functions in the body, Dr. Greenlee stresses. Although the study could not prove that carotenoids are harmful to cancer patients, the results heighten concern about carotenoids’ health effects, following on previous randomized controlled trials that found beta-carotene to increase the risk of lung cancer among smokers.

“Dietary supplements containing high doses of carotenoids may be harmful, and people should think twice before taking them.”

Greenlee H, Kwan ML, Kushi LH, Song J, Castillo A, Weltzien E, Quesenberry CP Jr, Caan BJ. Antioxidant supplement use after breast cancer diagnosis and mortality in the Life After Cancer Epidemiology (LACE) cohort. Cancer. 2011 Sep 27. [Epub ahead of print]

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MESSAGE FROM THE CHAIR Dear colleagues, Welcome to the December 2011 issue of Two by Two, the Epidemiology Department newsletter. Dr. Inge Goldstein, Special Lecturer in Epidemiology, is featured in this issue as a Pioneer Among Us for her groundbreaking early studies on air pollution and health. Our December faculty profile endeavors to capture the spirit of the prolific Dr. Lloyd Sederer, Adjunct Professor of Epidemiology and Medical Director of the New York State Office of Mental Health. And as always, we highlight the accomplishments of our faculty, staff, and students over the last two months. This issue also launches a new regular feature, Partner Profiles, in which we provide a closer look at the outstanding centers and institutes with which our faculty collaborate. These partnerships are essential to the cutting-edge interdisciplinary research and training conducted in Epidemiology, and our first Partner Profile, the Centre for the AIDS Programme of Research in South Africa (CAPRISA) is a superb exemplar. As we move toward the close of 2011, we are also beginning to reflect on the past year and to look ahead. We have a wealth of accomplishments to look back upon and exciting plans underway for the coming year. Many of these have been featured in the pages of Two by Two over the course of 2011. We will provide a comprehensive summary in our Department annual report, which will be published in January 2012. I would like to take this opportunity to say thank you once again to the faculty, students, and staff who have made Two by Two possible over the past 12 months. As always, we welcome comments and ideas for future issues of Two by Two.

SUBMIT TO TWO BY TWO

Wishing everyone a joyful and safe holiday season,

If you have a study, news story, award, or other milestone you’d like to share in Two by Two, please email Elaine Meyer at [email protected]

CLUSTER SEMINARS DECEMBER — JANUARY

with your submission.

SOCIAL EPIDEMIOLOGY

UPCOMING  DECEMBER — JANUARY

FRIDAY, DECEMBER 16

10:00-11:30

AM

PSYCH / NEURO EPIDEMIOLOGY THURSDAY, DECEMBER 1

12:30-2:00 PM

THURSDAY, JANUARY 26

12:30-2:00 PM

friday, december 2

staff meeting: pizza friday

Wednesday, DECEMBER 7

CUEGR: Paolo vineis, md, mph, ffph

Wednesday, DECEMBER 7

master’s students journal club

thursday, december 15

epi social: holiday party

friday, december 16

faculty meeting

EPIDEMIOLOGY INNOVATION

wednesday, december 21

special lecture: Sarinnapha Vasunilashorn, phd

WEDNESDAY, DECEMBER 21

wednesday, january 5

special lecture: theresa osypuk, sd, sm

CHRONIC DISEASE EPIDEMIOLOGY

monday, january 17

special lecture: dana march, phd

FRIDAY, DECEMBER 9

friday, january 20

faculty meeting

LIFECOURSE EPIDEMIOLOGY TUESDAY, DECEMBER 13

1:00-2:30 PM

TUESDAY, JANUARY 17

1:00-2:30 PM

8:30-10:00 AM

12:00-1:00 PM

monday, january 23

special lecture: siliva martins, md, phd

INFECTIOUS DISEASE EPIDEMIOLOGY

wednesday, january 25

cuegr: deborah winn, phd

FRIDAY, DECEMBER 9

3:00-4:30

PM

FRIDAY, JANUARY 27

3:00-4:30

PM

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PUBLICATION HIGHLIGHTS Cancer treatment responsiveness varies by genetic mutation Dr. Victor Grann co-authored an editorial in JAMA about the association between genetics and treatment outcomes for those with breast and ovarian cancer. Dr. Grann, Clinical Professor of Medicine, Epidemiology, and Health Policy and Management, commented on an accompanying study by researchers at the University of Texas who investigated women’s responsiveness to chemotherapy related to mutations in one of the 2 genes associated with breast cancer. Women with mutations in either the BRCA1 or BRCA2 gene have an elevated lifetime risk of developing breast or ovarian cancer. However, the Texas study found that women with BRCA2 mutations have an improved chance of survival compared to women with BRCA1 mutations or without mutations in either gene. This discrepancy “should encourage attention to the differences in treatment between the 2 groups, particularly among women with ovarian cancer,” says the editorial. “Further refinement in the understanding of the differences in the DNA repair deficits due to BRCA1 versus BRCA2 mutations could lead to therapy that is better targeted.” Grann VR, Parsons RE. Defining variations in survival of BRCA1 and BRCA2 mutation carriers. JAMA. 2011; 306(14): 1597-8.

Prenatal use of folic acid supplements may reduce risk of severe language delay in children A large pregnancy cohort study in Norway has found that maternal use of folic acid supplements during the period around conception could reduce the risk for severe language delay in offspring at age 3. Published in JAMA by senior author Dr. Ezra Susser, Professor of Epidemiology and Psychiatry, and lead author Ms. Christine Roth, a visiting researcher, the study adds to what is known about the use of folic acid supplements, which are commonly recommended for pregnancy. The researchers found that the risk for developing severe language delay among 3-year-olds was reduced twofold among women who took folic acid supplements during the period four weeks before conception and eight weeks after. The study was carried out from 1999-2008 and had a cohort of 38,954 children. Significantly, it is the first to look into the relation between folic acid and language development in infants. The researchers will follow up again with the children at age 5. Roth C, Magnus P, Schjølberg S, Stoltenberg C, Surén P, McKeague IW, Davey Smith G, ReichbornKjennerud T, Susser E. Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011; 306(14): 1566-73.

DECEMBER 2011 3

TOP PHOTO: ANNIE CAVANAGH, WELLCOME IMAGES

New evidence sheds light on timing co-treatment of HIV and TB A new finding in the ongoing Starting Antiretroviral Therapy at Three Points in Tuberculosis (SAPit) study has been published in the New England Journal of Medicine by Drs. Salim and Quarraisha Abdool Karim (Professor of Clinical Epidemiology and Associate Professor of Clinical Epidemiology, respectively), and co-authors Dr. Wafaa El-Sadr, Professor of Medicine and Epidemiology and director of ICAP, and Dr. Gerald Friedland, Adjunct Professor of Epidemiology and Professor of Medicine at Yale University. The study investigates how to time the treatment of individuals infected both with tuberculosis (TB) and HIV in sub-Saharan Africa. It is a critical issue for a region in which 70% of individuals with TB are also HIV-positive. Overlapping anti-retroviral therapy (ART) with treatment for TB poses the risk of increased side effects and other hazards. The timing, according to the study results, should depend on the state of the patient’s immune system. While those with stronger immune conditions could start ART treatment 3-months into TB treatment, individuals with a low T-cell count—a sign of an immune system that has been severely weakened by HIV —were better off if they began ART within the first four weeks of TB treatment. The latter group showed a two-thirds decline in the death rate, compared to those with severely weakened immune systems who had started ART later. For more on the history of SAPit, see page 17.

HIV TB

Abdool Karim SS, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q. Integration of antiretroviral therapy with tuberculosis treatment. N Engl J Med. 2011; 365(16): 1492-501.

Off-label use of female condoms poses health question A new study provides the first documented evidence that the female condom is being used for heterosexual anal intercourse, adding to questions about the vaginal contraceptive’s efficacy for off-label uses. The study in the American Journal of Public Health was first authored by Dr. Elizabeth Kelvin, a PhD graduate from the Department of Epidemiology, with coauthors Dr. Zena Stein, Professor Emerita of Epidemiology and Psychiatry, and Dr. Susie Hoffman, Assistant Professor of Clinical Epidemiology (in Psychiatry), along with other colleagues at the HIV Center for Clinical and Behavioral Research at the New York Psychiatric Institute / Columbia University and collaborators at Gay Men’s Health Crisis. The researchers surveyed 111 clients of an HIV/AIDS service organization in New York City finding that 17% had used a female condom for anal sex. Among that group, 21.4% used the condoms for anal sex with female partners. The female condom has been approved for vaginal use by the US Food and Drug Administration but not for anal use, highlighting “the urgent need to evaluate the safety and efficacy of the female condom in anal intercourse,” the study says. Kelvin EA, Mantell JE, Cendelario N, Hoffman S, Exner TM, Stackhouse W, Stein ZA. Off-Label Use of the Female Condom for Anal Intercourse Among Men in New York City. Am J Public Health. 2011 Oct 20. [Epub ahead of print]

DECEMBER 2011 4

Marijuana use may double risk of driving accidents Drivers who test positive for marijuana or who report marijuana use are more than twice as likely as other drivers to be involved in motor vehicle crashes, according to the results of a meta-analysis senior authored by Dr. Guohua Li, Professor of Epidemiology, with co-authors Dr. Charles DiMaggio, Associate Clinical Professor of Epidemiology; Ms. Joanne Brady, a PhD candidate; and Mr. Keane Tzong, an MPH candidate. The analysis, which pooled data from 9 epidemiologic studies conducted in 6 different countries, also indicates that 28% of fatally injured drivers and more than 11% of the general driver population tested positive for non-alcohol drugs, with marijuana being the most commonly detected substance. Dr. Li cautions against inferring from the epidemiologic data that marijuana use causes car accidents. However, “if the crash risk associated with marijuana use is confirmed by further research, this is likely to have major implications for driving safety and public policy,” he says. Li MC, Brady JE, Dimaggio CJ, Lusardi AR, Tzong KY, Li G. Marijuana Use and Motor Vehicle Crashes. Epidemiol Rev. 2011 Oct 4. [Epub ahead of print]

The Early Determinants of Adult Health Study: A milestone The first set of articles emanating from the Early Determinants of Adult Health (EDAH) and related studies have been published as a theme issue in the December Journal of Developmental Origins of Health and Disease. The seven papers include six on which MSPH faculty are first or senior author (Drs. Pam Factor-Litvak, L.H. Lumey, Ian McKeague, Ezra Susser, and Mary Beth Terry). The project is historically significant, as well as important for having developed a promising new resource. The core EDAH study, led by principal investigator Dr. Susser, combined two major US pregnancy cohorts born 1959-1966 to provide a large enough sample to study prenatal exposures and midlife health among same sex sibling pairs. Related grants by principal investigators Dr. Marybeth Terry and Dr. Pam Factor-Litvak extended the core study to other outcomes and other designs. Dr. Howard Andrews provided vital data management support, and Ms. Kim Fader was a superb project director of this complex study. The EDAH study was based in the Imprints Center for Genetic and Environmental Lifecourse Studies.

DECEMBER 2011 5

TOP PHOTO: BRIAN BUCKMAN, BOTTOM PHOTO: DAVID FLAM

IN THE NEWS Dr. Neugut comments on studies of vitamin supplements and cancer

In a Huffington Post column, Dr. Al Neugut offers some perspective on a widely-reported medical study that showed Vitamin E seemed to increase the risk of prostate cancer. Dr. Neugut, who is the Myron M. Studner Professor of Cancer Research (in Medicine) and Professor of Epidemiology, points out that nearly all of the randomized trials that have looked at an association between vitamin supplements and cancer have shown that, for people who are not vitamin deficient, there is no benefit in taking supplements to prevent cancer. “If anything, as the studies are starting to suggest, it may be more harmful than beneficial,” he says.

Dr. Schluger quoted in story about respiratory hazards of indoor stoves

Dr. Neil Schluger, Professor of Medicine, Environmental Health Sciences, and Epidemiology at NYPH/CUMC, is quoted in an article on PBS’s “News Hour” website about the adverse health effects of stoves used in fast-developing nations like India. The makeshift stoves, which families typically power by burning wood, dung, or other biomass fuels, emit smoke and pollutants that contribute to an estimated 2 million deaths a year, according to new figures by NIH. “This creates levels of air pollution in homes that are astronomical, hundreds of times more than what you might breathe in New York, for example,” says Dr. Schluger, who is also chief scientific officer at the World Lung Foundation. The United Nations Foundation is currently working on an initiative to create a demand for cleaner electric or solar-powered stoves.

Dr. Salim Abdool Karim comments on tenofovir’s effectiveness against herpes

In 2010, the CAPRISA trial of tenofovir vaginal gel found that it not only lowered the likelihood of HIV transmission in women but did an even better job of protecting them against genital herpes. At the time, it was not clear why. Now, a follow-up study by researchers from the National Institutes of Health (NIH), Gilead Sciences Inc., and universities in Belgium and Italy, reported on in October by the New York Times, has biologically confirmed tenofovir’s preventative effect on herpes transmission using lab experiments. “We were very pleasantly surprised to see such a potent effect. However, until now, we had only a hypothesis for the mechanism of action—no clear-cut data,” says Dr. Salim Abdool Karim, director of the 2010 CAPRISA trial.

DECEMBER 2011 6

BRIEF MENTIONS

MPH alum receives APHA abstract award

MPH alum receives APHA best paper award

Laura Stadelmann, MPH ’11, received the American Public Health Association’s (APHA) Epidemiology Section Student Award, for her abstract “Comparing models of HIV transmission risk on concurrent HIV/ AIDS diagnosis using multiple imputation and other methods for handling missing risk data, New York City 2008.” Ms. Stadelmann is currently a Council of State and Territorial Epidemiologists Applied Epidemiology Fellow at the New York City Department of Health and Mental Hygiene.

Dustin Carpenter, MPH ’11, has been awarded the 2011 Best Paper Award for the Injury Control and Emergency Health Services Section of APHA. His winning paper was adapted from his thesis on road safety, titled “Graduated driver license night-time compliance in US teen drivers involved in fatal motor vehicle crashes.”

Dr. Lumey joins University of Chicago’s Health Inequality Network

Dr. Genkinger and Dr. Hall awarded Calderone Junior Faculty prize

Dr. Greenlee receives leadership award from the Society of Integrative Oncology

Dr. L.H. Lumey, Associate Clinical Professor of Epidemiology, was invited to become a member of the Health Inequality Network, a multidisciplinary research network at the University of Chicago. The aim of the group is to combine insights from several disciplines into a unified approach, in order to build up a comprehensive framework for the emergence and the evolution of health disparities over the lifecycle and across generations.

Dr. Jeanine Genkinger, Assistant Professor of Epidemiology, and Dr. Megan Hall, Associate Research Scientist, have each been awarded one of this year’s 3 Calderone Junior Faculty Awards. The prestigious award supports the research efforts initiated by junior faculty at the Mailman School. We are proud that Epi won 2 out of 3 of this year’s Calderone awards.

Dr. Heather Greenlee was honored with the Outstanding Service Award in Leadership at the Society for Integrative Oncology’s annual international meeting.

DECEMBER 2011 7

Dr. El-Sadr honored by Infectious Diseases Society of America Dr. Wafaa El-Sadr, director of ICAP and Professor of Epidemiology and Medicine, has been selected by the Infectious Diseases Society of America (IDSA) to receive the 2011 Society Citation Award for her outstanding contributions to the field of infectious disease. First presented in 1977, the Society Citation is a prestigious award that recognizes exemplary contribution to IDSA and outstanding achievements in the field of infectious diseases in research, clinical investigation, or clinical practice.

AWARDS & GRANTS Dean Fried honored at Bipartisan Congressional Awards Gala In a ceremony attended by approximately 300 members of Congress and key Executive Branch figures, the Alliance for Aging Research honored Mailman School Dean Linda P. Fried at its 25th Anniversary Bipartisan Congressional Awards Gala held in Washington, D.C. Dean Fried, who is also the DeLamar Professor of Public Health and Professor of Epidemiology and Medicine, was presented with the organization’s inaugural Silver Innovator Award for her work as a scientist who has been an exemplary leading innovative researcher in improving the health and well-being of aging Americans.

Dr. Ottman awarded grants to research epilepsy Dr. Ruth Ottman, Professor of Epidemiology (in Neurology and the Sergievsky Center), was awarded R01 funding from the National Institute of Neurological Disorders and Stroke funding program, called Centers without Walls for Collaborative Research in the Epilepsies. The project, entitled “Epi4K: Gene Discovery in 4,000 Epilepsy Genomes,” is designed to identify genetic variations that contribute to risk for specific forms of epilepsy using whole genome or whole exome sequencing in 4,000 affected individuals. It includes six linked R01 grants (three cores and three scientific projects), each of which has multiple principal investigators from an international team. Dr. Ottman is principal investigator on two of these grants, worth a total of $3.1 million.

Drs. Hornig, Lipkin, and Hammer awarded chronic fatigue grant Drs. Mady Hornig and Ian Lipkin of the Center for Infection (CII) and Immunity have been awarded a substantial grant from the Chronic Fatigue Initiative to investigate the role of pathogens in causing chronic fatigue syndrome. Dr. Hornig, an Associate Professor of Epidemiology and Director of Translational Research at CII, will direct research on biomarkers and pathogen discovery. The Initiative was established by the Hutchins Family Foundation with a donation of more than $10 million in order to study chronic fatigue syndrome. The initial phase of funding also supports New York-Presbyterian Hospital/Columbia University Medical Center, where the Hutchins Family Fellowship in Infectious Disease will be established under the direction of Dr. Scott Hammer, Professor of Medicine and Epidemiology. “This is a truly exciting opportunity to understand the causes of this often neglected disorder,” said Dr. Hornig. “We hope our findings will lead to better diagnoses and the development of an effective treatment.”

SUBMITTED GRANTS DEPARTMENT OF EPIDEMIOLOGY, JANUARY–NOVEMBER 2011

ASSISTANT PROFESSOR ASSOCIATE PROFESSOR PROFESSOR 0 JAN

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PROFILES New York’s chief psychiatrist ventures into public writing In 2009, after nearly 35 years practicing as a psychiatrist, and with a CV full of academic journal publications and textbooks, Dr. Lloyd Sederer, the chief medical officer of the New York State Office of Mental Health (OMH), began writing for a different audience. He had always enjoyed writing, having published his first medical articles in the American Journal of Psychiatry when he was a resident. “I was pretentious back then,” he says, scoffing a bit at the punny title of some of his early articles: “Moral Therapy and the Problem of Morale” and “Second-Hand Rose”. But Dr. Sederer, who in addition to being New York’s chief psychiatrist is an Adjunct Professor of Epidemiology, didn’t think his academic publications were getting him any closer to patients and their families—the groups he truly wanted to reach. “I was trying to speak to the people who received services,” he says. “They are the ones who need to understand medical care. They are yearning for someone to help them and in a personal way, to answer questions like, ‘Why’s it so impossible to get an appointment? Why does my loved one not get better? Where do I turn when that happens? Why does the doctor not answer my calls?’ “I started to realize, answers to those questions are not what’s in journals.” So Dr. Sederer approached the world of online media. A professional writer friend of his introduced him to an editor at The Huffington Post who quickly responded that the website wanted to publish an article he had sent in. Soon, his pieces were appearing regularly in the The Huffington Post.

FACULTY

Lloyd Sederer Today Dr. Sederer serves as a medical editor of mental health for the Huffington Post. His work has also appeared in the International Herald Tribune/New York Times, the WSJ.com and Washington Post, and he runs a website called Ask Dr. Lloyd (askdrlloyd.com), which is dedicated to helping people figure out how to get care for a mental illness or addiction. His writing combines story-telling with facts, figures, and an insider’s insights about mental health care in America. Several of his columns have used journalistic techniques to highlight the story of a troubled patient or a family member in despair. “A literary friend of mine told me this is called ‘narrative non-fiction,’ another said it was memoir,” he says of an October 5 piece he wrote for Psychiatric Times. “All I know is that it is a true story.” In that article, Dr. Sederer recounts his experience as a young intern in a Veterans Administration hospital. He is assigned to evaluate Billy, a 19-year-old Vietnam War veteran for a pre-trial evaluation pending a court martial for robbing dead American soldiers. Dr. Sederer must decide whether Billy is suffering from a psychotic disorder or is a criminal. After meeting daily, Dr. Sederer comes to believe Billy has a mental illness that has been made worse by a difficult childhood, drug abuse, and the war. Dr. Sederer makes a convincing case in a grand rounds session that Billy should not be treated as a menace to society. “Billy taught me more about mental illness than any book or paper I had read or seminar I had attended that year,” he says in the article. Despite being chief medical officer of the largest mental health care system in the country, he is not shy about calling out the mental health care system’s inadequacies. “Mental health care in the U.S. is broken, as you have or soon will see,” Dr. Sederer says in a Huffington Post article that gives advice for those who have family with a mental illness. “Like it or not, you will need to become a vocal spokesperson for what your loved one needs in a system that is fragmented, not organized to be accountable, not funded to incentivize effective care, and very uneven in its quality, despite good people trying to do the right thing,” he continues. It is an insight gleaned firsthand from his many years in hospital administration positions, including as medical director and C O N T I N U E D O N PAG E 1 0

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FACULTY APPOINTMENTS AND PROMOTIONS Grace Hillyer appointed Associate Research Scientist in the chronic disease epidemiology cluster Megan Horton appointed Associate Research Scientist in the lifecourse epidemiology cluster Peter Stastny appointed Lecturer in the lifecourse epidemiology cluster

PROFILES

FACULTY

Lloyd Sederer

CONTINUED FROM PAGE 9

executive vice President of McLean Hospital in Belmont, Mass., a Harvard teaching hospital. After 11 years at McLean and most of his adult life spent in Boston, he moved to New York City to become executive deputy commissioner for mental hygiene services in at the Department of Health and Mental Hygiene. Not long after beginning his tenure at OMH in 2007, he implemented sweeping reforms in licensing of mental health clinics in the state—basing the process on clinical care rather than paperwork and “exit signs.” The effort came about in 2009 after several gruesome murders might have been prevented, Dr. Sederer found, had the people involved gotten good mental health treatment. He reported on this story with his boss, Commissioner Michael Hogan, in Health Affairs in 2009. The new licensing requirements mandate communication between caregivers, screening for drug and alcohol use, and having someone on call and available to patients and families after 5 pm, all previously not expected by the state’s licensing procedures. Public writing, Dr. Sederer likes to say, is very reinforcing. Articles are published days after they are written and readers can get in touch with him directly—and do—when they have a question or comment about his article. While Dr. Sederer says he cannot give medical advice to those who contact him by email, he wants to serve as a public, human face of mental health, a doctor who can at the very least encourage people to seek treatment and assure them that mental disorders need not

be a life sentence. Although he intends to keep his day job— the Huffington Post gig is unpaid—Dr. Sederer has taken on increased writing and editorial responsibility for a number of publications. He is also frequently called on to review movies and books, focusing in particular on those that say something about the human condition. These days, he is finding himself getting pretty comfortable in his new role. At a fundraising dinner for autism, he was seated at the same table as New Yorker editor David Remnick, who complimented Dr. Sederer on his work as a public servant. When they exchanged contact information, Dr. Sederer opted for slipping Mr. Remnick his Huffington Post card instead of the OMH card.

A selection of Dr. Sederer’s articles “Crime in the Military: Madness, Badness, and Survival” in Psychiatric Times (October 5, 2011) “Advice for Those with a Loved One With Mental Illness” in The Huffington Post (March 14, 2011) “Ink-Stained for Life” in The International Herald Tribune/New York Times (December 23, 2010) “Pay for Health Reform with an Alcohol Tax” with Eric Gopelrud in The Washington Post (September 28, 2009) “Mental Health Crises and Public Policy” with Michael Hogan in Health Affairs (Vol 28, No 3, 2009)

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PROFILES As the Senior Cluster Administrator (SCA) for the chronic disease epidemiology cluster, Kathleen Flandrick’s intelligence and professionalism is well known to faculty and fellow staff. “Kathleen is so good at her administrative and organizational activities that I have to make up reasons to go in to talk to her,” says chronic epidemiology cluster leader Dr. Al Neugut. Her duties include handling the cluster’s pre- and post-award grant administration and management, along with many other projects. She also serves as a liaison between chronic disease epidemiology faculty and staff and the Department’s central administration. “She supports an extremely productive group of the Department’s faculty, and she’s done a fantastic job of becoming fluent in their various activities and research projects in a very short period of time,” says Christina McCarthy, interim Department Administrator. Kathleen appreciates how being an SCA keeps her involved with both public health and grant making. “The chronic disease cluster has a diverse set of research activities and funding sources, and they always keep me on my toes,” she says. Arriving here this past June, Kathleen came with a wealth of education and experience in public health and administration, including an MPH from University of Pennsylvania. While there, she worked as a research program development manager, project managing large institutional grant proposals and editing and producing an annual grant writing manual. She has also worked as a financial administrator in London at South Bank University’s business school, and as an administrative specialist at the Amherst H. Wilder Foundation in St. Paul, where she edited and designed a collaborative newsletter, organized large events, and worked closely with grantees on reporting.

DECEMBER 2011 11

STAFF

Kathleen Flandrick In New York, she has worked as a development associate at Regis High School on the Upper East Side, where she managed the daily operations of the annual fund, edited and designed the monthly magazine, and produced the annual report. She also worked as a grants coordinator at the CUMC Dental College, where she focused on pre-award grant administration. Kathleen hails from Stillwater, Minnesota. Her parents have a small organic farm where they raise free range chickens, sheep, pigs, and bees. A number of animals keep watch over the farm, including a llama, several Chinese geese, and two large dogs. Currently, she and her husband, an emergency medical resident at Stony Brook University Medical Center, live in Great Neck, Long Island, the halfway point between their jobs. Her commute to Columbia gives her ample time to read fiction. A recent favorite of hers was Jennifer Egan’s A Visit from the Goon Squad. In her free time, Kathleen enjoys catching live indie or punk rock shows, visiting her friends in Brooklyn, and taking in modern and contemporary art. Some of her favorite artists are Richard Serra, Anselm Kiefer, Gordon Matta-Clark, and Zoe Strauss. Both travel enthusiasts, Kathleen and her husband recently visited Iceland and are planning a vacation to Istanbul in the spring.

STAFF APPOINTMENTS AND PROMOTIONS Emil Fraija appointed Financial Coordinator in the social epidemiology cluster Scott Skversky appointed Senior IT User Support Technician in the office of the Department Chair Melissa White appointed Project Coordinator in the chronic disease epidemiology cluster

Master’s Student Day Practicum Day awards

Best abstracts First place  Patrick Dawson, Infectious disease epidemiology, for “The epidemiology of tuberculosis among New Yorkers living in public housing, 2001-2009” Second Place  Ashleigh McGirr, Epidemiology innovation, for “Assessing the effects of human behavior in distributing post exposure prophylaxis: A computer simulation approach” Third place (tie)  Rhea Powell, Chronic disease epidemiology, for “Does genetic ancestry modify the relationship of smoking to lung function? The MESA Lung Study”

First annual Master’s Student Day showcases student work On October 28, the Department of Epidemiology held its first annual “Epi Master’s Student Day.” The event was created to give master’s students an experience similar to that of presenters at professional conferences. The event kicked off with an hour-long session in which master’s students in all six Department clusters presented posters about their practicum research and experience. The diversity of practicum sites offered by the Department was well represented, from the New York City Department of Health and Mental Hygiene to UNICEF Ghana, from the National Institutes of Health to the Shanghai Centers for Disease Control. Faculty and students also gathered to listen to presentations by our 3 abstract winners and to ask questions, which allowed our students to demonstrate their command of complex epidemiologic principles. The winners also received cash prizes. Special acknowledgements go out to Dr. Joyce Pressley, who heads up the practicum program and brought this impressive event together. Ebony King, Anthony Diaz, Erin Gilbert, Liliane Zaretsky, and Elizabeth Ferrari were critical in making sure the event happened smoothly. Dr. Ruby Senie, Dr. Parisa Tehranifar, and Dr. Megan Hall reviewed and submitted abstracts and judged posters. PhD students Carolyn Herzig and Catherine Richards and master’s students Diane Addison, and Patrick Dawson also helped with all stages of the event. We look forward to this becoming a long-term tradition in the Department, showcasing the best of our students’ work. Following is a list of the winners of our practicum awards, in the best abstracts category and in the best posters category, which was broken down by cluster:

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Sarah Reber, Epidemiology innovation, “Child protection systems and outcomes in Northern Uganda CPC Learning Network”

Best posters Chronic disease epidemiology (tie)  Jennifer Brite, “Height and the risk of gestational diabetes: Does maternal wrace make a difference?” Stephen Mooney, “Using Google Street View to assess physical characteristics of neighborhoods” Epidemiology innovation  Alexandra Kravitt, “Birth outcomes among pregnant women exposed to the World Trade Center attacks on September 11, 2001” Infectious disease epidemiology (three-way tie)  Stephanie Shiau, “Body composition and metabolic abnormalities of perinatally HIVinfected children in South Africa on long-term ARV treatment” Man Kai (Alyssa) Wong, “Strengthening active case finding of tuberculosis among deported migrants in Cambodia” Frank Zadravecz, “Spectral decomposition of the viral meteorological seasonal forcing reactivated tuberculosis incidence in urban Brazil” Lifecourse epidemiology  Colette Friedenson, “Do offspring of mothers exposed to constant, low levels of organochlorine compounds have increased risk of autoimmune thyroid disease?” Psych/neuro epidemiology  Seema Kara, “Socioeconomic disparities and modifiable risk factors amongst people with serious mental illness” Social epidemiology  Niloufer Taber, “Castle Gardens: Affordable and supportive green housing for low-income New Yorkers”

A new journal club for master’s students On a recent Wednesday afternoon, 15 master’s students went around a table, each describing his or her “neighborhood food environment.” They weren’t there to discuss restaurant recommendations, however, but to analyze a journal article published in 2009 called “Neighborhood food environment and walkability predict obesity in New York City” for the second meeting of the Master’s Student Journal Club. The club was started this fall by Patrick Dawson, MPH ’12, with Catherine Richards and Carolyn Herzig, doctoral students and the doctoral liaisons to master’s students. Its purpose is to allow master’s students to discuss important papers in epidemiology and to practice critically evaluating epidemiological literature. The group typically meets every other Wednesday from 2-3 pm in the Environmental Health Sciences conference room. At each meeting, a different student comes prepared to lead a discussion on an article of his or her choosing. On this particular Wednesday, MPH ’12 student Spruha Joshi was leading the discussion of the neighborhood food environment paper, which was authored by Dr. Andrew Rundle, Dr. Gina Lovasi, Ms. Richards, and colleagues and published in the journal Environmental Health Perspectives. Ms. Joshi, whose research interest is in chronic disease epidemiology, says she chose the article in part because it was authored by researchers affiliated with the Department with whom she is involved at the Built Environment and Health (BEH) research group. Among the subjects discussed were how the researchers defined several variables like neighborhood food environment, neighborhood walkability, and healthy options available at a food establishment. They use three categories to classify food establishments: “BMI (body mass index)-healthy,” “BMI intermediate,” or “BMI unhealthy.” This led some students to question the classification of certain stores as uniformly healthy or unhealthy. “Any given store has both healthy and unhealthy options,” one student said. Adding that the data was 10 years old, another participant suggested that an analysis of more current data should include establishments like farmers markets and food carts, which weren’t factored in to the original study. At the end of the hour, Ms. Joshi teased out the rationale for critiquing journal articles. “Critiquing research isn’t bad form,” she said, “it is important to help the researchers know what gaps still exist.” Ms. Richards added that it is important for scientists to publish findings, even if they don’t have all the data they would like to have in an ideal world, in order to circulate results and get funded for future studies. For instance, the BEH group was aware at the time of publication that the BMI-intermediate group wasn’t perfectly

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classified but didn’t have the resources or available data at the time to better understand that category. (Since the paper was published, the BEH group received funding to hire high school interns to walk around NYC neighborhoods using validated food questionnaires to audit various food establishments). According to Mr. Dawson, most of the students who came to that meeting of journal club were interested in chronic disease topics, while the students at the first meeting of the year, which took up an infectious disease epidemiology article, tended to be interested in that area. “It’s helpful for me,” said Dawson, who himself is interested in infectious disease epidemiology, “because I’m constantly being exposed to different topics and approaches.” Next journal club meeting: Wednesday, December 7, 2-3 pm in the Environmental Health Sciences Conference Room (1101)

First EPIC Fund Cycle awards

Epidemiology and P Summer Institute a

In October, six trainees were awarded funds in our first EPIC Fund cycle from a total of 13 applicants. The EPIC Fund was established by the Department to provide our trainees with an opportunity to access resources beyond those covered by their standard tuition. Drawn from revenue generated by our annual summer institute, EPIC, trainees apply for funding for such things as travel; purchase of datasets or samples for a study; and expenses for short workshops, software packages, or training in lab techniques. The next funding cycle will be in January 2012.

PARTNER

PROFILES This is the first of our “Partner Profiles.” Over the coming year, Two by Two will feature some of the many innovative centers across the University with which the Department of Epidemiology partners.

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PARTNER PROFILES DR. Quarraisha ABDOOL KARIM explains the tenofovir gel trial to Mr. Michel Sidibé, the executive director of UNAIDS, with Dr. Salim Abdool Karim looking on.

A crosscontinental partnership for AIDS and tuberculosis research CAPRISA and the Department of Epidemiology

I

n 2010, the Centre for the AIDS Programme of Research in South Africa (CAPRISA) announced at the International AIDS Conference in Vienna that the vaginal gel containing 1% of Gilead Sciences’ antiretroviral agent, tenofovir, had been effective in reducing HIV infection among women by 39% overall and by 54% in women who used the gel consistently. The announcement was based on a clinical trial carried out at two sites in South Africa led by Dr. Salim (often known as Slim) Abdool Karim and Dr. Quarraisha Abdool Karim, respectively the director and associate scientific director of CAPRISA. The results of the CAPRISA 004 trial, which made front page headlines across the world including The New York Times, Wall Street Journal, and Washington Post, were celebrated in the HIV/AIDS research community and by women in Africa, both groups who had become accustomed to the stream of disappointing news that came out of most HIV prevention trials.

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For the Department of Epidemiology, where both Abdool Karims have faculty appointments, the tenofovir trial was emblematic of a commitment to public health research and interventions that are shaped by social realities. It also highlighted the long history the Abdool Karims have with the Department, dating back to their time as graduate students here in the late 1980s, when they studied and experienced the public health response to the HIV epidemic in New York City. While the collaboration between Columbia and CAPRISA was made official nearly one decade ago, when the latter was founded, the relationship between the Abdool Karims and the Department of Epidemiology has endured for nearly 25 years. “It is a cross-Atlantic partnership that has deep roots going back the fight against apartheid and the struggle for human rights, social justice and health for all,” Slim says.

Education in Epi The couple came to New York in 1987 so Slim, a physician, could begin a new fellowship started at the Gertrude H. Sergievsky Center by Dr. Mervyn Susser to train South Africans in public health. Slim enrolled in the MS in epidemiology program at Columbia in 1987 and Quarraisha joined him at the beginning of 1988, doing research in the Microbiology laboratory while studying epidemiology and parasitic diseases at Columbia. During their year in New York, the newly married couple became involved with the public health debates about AIDS. Quarraisha was mentored by Dr. Zena Stein who would, in 1990, publish a

PARTNER PROFILES

Dr. Quarraisha Abdool Karim explains how to use an applicator.

groundbreaking article about HIV prevention in the American Journal of Public Health that highlighted the importance of HIV prevention methods that women could control. “She really imprinted on me the importance of looking at everything through a gendered lens,” Quarraisha says. After the Abdool Karims returned to South Africa at the end of 1988, Slim started his 3-year residency in public health medicine at the Nelson R. Mandela School of Medicine. Meanwhile, Quarraisha began her career in public health research at the South African Medical Research Council. As she was working to establish research priorities, she thought of her experience in New York, having seen the HIV epidemic’s effects on communities like Greenwich Village, Harlem, and the Bronx. It inspired her to conduct one of Africa’s first population-based studies on AIDS in rural districts of the province of KwaZulu-Natal. The study results showed that a disproportionate impact of the HIV burden was born by young women, and that transmission was intertwined with population migration. Furthermore, women on average were 5 to 7 years younger when they acquired the virus than men, suggesting that female-targeted prevention had to begin at an early age. “This study was one of the first reasons why we started focusing on women,” Quarraisha says. The study also suggested that the worst was yet to come, that “we were only at the very early stage of the epidemic.”

Joining the epi faculty In 1994, the couple returned to New York for a semester, this time as faculty. They taught infectious disease epidemiology in the Department, worked with Dr. Zena Stein to set up the Fogarty AIDS International Training and Research Program, and established several collaborations to build their AIDS research efforts in South Africa. Since then, they have continued as faculty in Epidemiology, including in their Mailman collaborations with Dean Allan

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Rosenfield, Dr. Alan Berkman, Dr. Ron Bayer, and Dr. Anke Ehrhard. In 1995, Quarraisha was appointed by Nelson Mandela’s government to lead the country’s AIDS control program, where she faced the daunting task of converting evidence into policy and policy into action. During this time, Slim was the director of the South African Medical Research Council’s Center for Epidemiologic Research in South Africa (CERSA) and in 2001 took up the position of Deputy Vice-Chancellor for Research at the University of KwaZulu-Natal in Durban.

Founding of CAPRISA CAPRISA was established in 2002 through a groundbreaking agreement that brought five partner institutions together, made possible by a National Institutes of Health (NIH) grant. The various legal and other requirements of each partner institution, and the trans-continental relationships between Columbia and the four South Africa institutions (University of KwaZulu-Natal, University of Cape Town, University of Western Cape, and the National Institute for Communicable Diseases in Johannesburg) made the agreement both a challenge and a great achievement, Slim says. At the outset CAPRISA became an official research center at both Columbia and the University of KwaZulu-Nata, one of only two organizations that received funding in the first cycle of the NIH’s new Comprehensive International Program of Research on AIDS (CIPRA) to fund international centers of excellence in AIDS research. CAPRISA today has a strong collaborative relationship with several senior faculty members of the Department of Epidemiology. Drs. Zena Stein, Mervyn Susser, Wafaa El-Sadr, Scott Hammer, Sharon Schwartz, Al Neugut, Ian Lipkin, Seth Berkley, and Ezra Susser all work with CAPRISA scientists. With several collaborating research laboratories across the country, the organization has a significant presence in Durban, Cape Town, and Johannesburg. CAPRISA has clinics that are accessible for walk-in patients in the Durban city center and rural Vulindlela, about 90 minutes from Durban.

PARTNER PROFILES The year 2010 was a triumphal one for the organization. In February, CAPRISA came out with the results of the seminal Starting Antiretroviral Therapy at Three Points in Tuberculosis Therapy trial (known as “SAPiT”), which made recommendations on treating concurrent TB and HIV. (Treatment of a patient with both diseases can often cause serious side effects, which has made it difficult for doctors to decide when to start antiretroviral therapy during TB treatment). The World Health Organization and the US Department of Health and Human Services subsequently used SAPiT as the basis for their guidelines for the treatment of TB-HIV co-infected patients. When fully implemented, the findings of SAPiT could save thousands of lives a year, Slim says. Then there was the announcement of the CAPRISA 004 findings, which was ranked in the “Top Ten Scientific Breakthroughs of 2010”by the journal Science. The Abdool Karims had begun their first microbicide trial in 1993. They first investigated the feasibility of a vaginal microbicide by interviewing the sex workers who frequented truck stops in South Africa—a population that was considered significantly at-risk for HIV transmission. Although their early trials met repeated failure, the exigencies of the time made it impossible to stop working on the technology; an HIV prevention method for women was desperately needed. “In many ways, you have to be somewhat pig-headed to persist in the presence of all of this failure,” Slim says. “When the going got tough, our friends and colleagues in Epi were always sympathetic and actively supported us in our efforts to stay the course.” By the late 1990s, the HIV epidemic in South Africa was no longer asymptomatic—that is, people had moved past the early stages of infection and were now showing telltale AIDS symptoms and dying, much like the US experience in the mid-to-late 1980s. The trend of women being infected with HIV at a higher rate than men continued to bear out in the higher number of young women presenting to hospital with AIDS. “We were constantly being reminded about the needs for methods that women could initiate and use,” Quarraisha says. “As we continued to do our prevention work and tried to identify uninfected women, we started to find more women who were infected than uninfected. It was a dire response to a real situation. It wasn’t whether we wanted to do it. We had to do it.”

Dr. Salim Abdool Karim

“The idea is to make enough gel to supply the whole of Africa on a straight not-forprofit basis.”

The future of CAPRISA Despite the good news of the tenofovir trials, the Abdool Karims’ agenda for CAPRISA has not slowed. They are now conducting a TB prevention study that looks at HIV patients who get infected for a second time with TB. Quarraisha is also heading up a study that focuses on preventing HIV by incentivizing certain behaviors in adolescents. The 2,500 school children enrolled will receive a financial incentive every time they engage in certain preventative behaviors, such as getting HIV testing. They also will receive money as an incentive if they do well academically, based on findings that the longer children are in school, the less likely they are to contract HIV. A trial of a new AIDS vaccine—thus far an elusive goal for AIDS researchers—is also being planned for 2012 with a research group from Harvard. As for tenofovir gel, it is currently going through what are called confirmatory trials, including the VOICE study of 5,000 women and

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the FACTS001 study that is like an expanded CAPRISA 004 study. If these are successful and the gel becomes an approved medicine, the gap between evidence, policy, and implementation will be substantially reduced owing to an early entreaty CAPRISA made with Gilead headquarters in California to secure a royalty-free license, which has now enabled a joint government—private partnership to manufacture and distribute the gel. “The idea is to make enough gel to supply the whole of Africa on a straight not-for-profit basis,” Slim says. It is a remarkable prospect, considering most pharmaceuticals take years to make it to a mass market in Africa. It signifies the way in which CAPRISA bridges science and implementation, as well as evidence and public health. Says Slim: “We’ve never seen ourselves in any other way than being scientists of the world.”

PIONEERS AMONG US Inge F. Goldstein, Special Lecturer in Epidemiology, has spent nearly 45 years at the Mailman School of Public Health, researching the health effects of air pollution, air-borne allergens, and asthma. She was one of the earliest researchers to realize, as the late Dean Allan Rosenfield put it, that “asthmatics [might] be canaries in the mine shafts—a sensitive population whose health status might have implications for all of us.”

INGE

GOLDSTEIN T

hrough her research, she “pioneered in thinking about how urban environments contribute to the burden of asthma and developed new methods for studying air pollution and health,” says Dr. Jonathan Samet, Director of the Institute for Global Health at University of Southern California. “She was among the first to notice that people who live in northern urban environments spend more time indoors than outdoors and to study the health effects of indoor environmental exposures. She was also among the first to use time-series approaches to investigating air pollution, now a standard and informative methodology. She did this work in a typically quiet but determined fashion, and, in my opinion, she should have been more widely recognized for her early contributions.” From biophysics to epidemiology Dr. Goldstein came to the US in 1949 after serving in the Israeli army during the War of Independence. She earned a degree in chemistry at Wellesley College and a master’s in biophysics from the University of Pittsburgh. She began PhD courses at the University of Michigan but interrupted her graduate work to move to New York City in 1965 with her husband and their 3 children. There, her career plans changed as she became interested in the possibility of applying the scientific rigor of the physical and natural sciences in which she had been trained to studying health-related issues of communities.

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From a chance meeting with Dr. Jack Elinson, the founder of the Mailman School’s Department of Sociomedical Science, Dr. Goldstein learned about the field of epidemiology, which seemed to represent exactly this kind of research. Dr. Elinson suggested she talk to Dr. Mervyn Susser, the Chair of what was then known as the Division of Epidemiology. Under Dr. Susser’s supervision, Dr. Goldstein in 1968 began studying health effects of air pollution. During this time, public awareness of air pollution had led to acrimonious debates between affected communities and industry. Observing that these conflicts sorely needed good science, Dr. Goldstein served as a scientific adviser to the New York City Department of Environmental Protection (DEP) and testified as an expert witness for the New York City Department of Health in a dispute over Consolidated Edison Co.’s application for an exemption from fuel quality standards. After the hearings ended, Mitchell E. Blum, the Department of Health’s director of air pollution studies, wrote her a grateful letter of praise for having “taken risks that others might have chosen to avoid; withstanding cross-examination in a legal proceeding that is not the

accustomed milieu of a research scientist and teacher.” Dr. Goldstein was also appointed as an epidemiologist on an expert committee assembled by DEP to evaluate a lawsuit filed by a group of Bronx parents over a landfill in their neighborhood where toxic chemicals had been illegally dumped . The parents alleged that the dumping was responsible for excess leukemia cases in their children. During the trial, Dr. Goldstein also served as an interpreter of the scientific issues involved to the mostly lay audience at the hearings. Toward a rigorous measurement of air pollution Shortly after beginning her work and study for the MS in Epidemiology at the Mailman School, Dr. Goldstein authored her first paper, which pointed out the weaknesses in the thencustomary methods of correcting for weather variables in air pollution monitoring. Subsequent papers based on collaborative studies with Dr. Leon Landowitz of the City University of New York demonstrated the inadequacy of using a single, centrally-located monitoring station on a Manhattan rooftop to represent people’s exposure to air pollution across all five boroughs of New York City. The research also showed that the other 45 aerometric stations around the city did not provide a good representation of air pollution in their immediate neighborhoods. The papers attracted considerable attention in the field and led to better accuracy in future assessments of air pollution exposure. After earning her DrPH in 1975, Dr. Goldstein moved into developing new statistical methods to study the health effects of air pollution regulation, working with Dr. Jack Cuzick of Oxford University. In the 1980s, Dr. Goldstein was the first researcher to go into inner city homes to conduct measurements of indoor air pollutants, including emissions from gas stoves, which were often used by residents not only for cooking but also for supplemental heating in the winter. She recruited families in poor African American and Hispanic neighborhoods with high asthma prevalence to participate. The studies could be trying, but the families were cooperative, allowing Dr. Goldstein’s study team to bring cumbersome equipment into their homes to measure pollution levels, and agreeing to wear personal exposure monitors. Drawing on these studies, Dr. Goldstein, with Dr. Charles Reed of the Mayo Clinic, pioneered indoor air monitoring of allergens. They helped

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Dr. Goldstein was the first researcher to go into inner city homes to conduct measurements of indoor air pollutants, including emissions from gas stoves

show that allergens and chemical irritants in people’s homes, particularly allergens emitted by cockroaches and mice, and pollutants from gas stoves and space heaters, could be significant triggers of asthma. Understanding asthma epidemics Although not a communicable disease, asthma occasionally occurs in “epidemics”—periods of a day or two in which attacks, as measured by daily emergency room visits, skyrocket to ten or twenty times the usual number. Such epidemics have occurred in disparate parts of the world: New Orleans, Brisbane (Australia), Barcelona, and to a lesser extent New York City. For decades these events went unexplained. Then, in the late 1980s, with the help of statistical methods Dr. Goldstein and colleagues had developed, Drs. Josep Anto and Jordi Sunyer demonstrated that the Barcelona epidemics occurred only

LEFT PHOTO:UNITED NATIONS, RIGHT PHOTO: STEVEN DEPOLO

“Inge has been a mentor to many young scientists, like me. She encouraged and fostered the development of novel and innovative research projects that helped me develop an independent research program.”

“One of Inge’s many inspirational qualities is her interest in and concern for everyone with whom she has worked. She encouraged me to get an MPH, to get up the courage to apply to the doctoral program in epi, and was there for me when I went back to asthma research after spending many years researching cancer.”

Dr. Judith Jacobson

“She brings a lot of wisdom to the table, and she remains very careful in terms of reminding us how to ask and look at research questions as an experienced epidemiologist.”

Dr. Matthew Perzanowski

“Dr. Goldstein is one of the most dedicated professionals in the field of environmental epidemiology. As a former student of hers, I am continually impressed by her commitment to educating the public, her concern about environment justice, her dedication to helping students refine their interests in this field, and her adherence to rigorous scientific standards when investigating environmental hazards.”

Dr. Andrew Goodman

Dr. Rachel Miller “Dr. Goldstein is a gifted and inspiring scientist, teacher, researcher, advocate and mentor, and I am grateful to have been touched by her wisdom, patience and leadership in the field of environmental epidemiology.”

Dr. Susan Klitzman

when cargoes of soybeans, whose dust contains allergens, were being unloaded in the harbor. After the appropriate filters were installed, the epidemics disappeared. Building on their findings, Dr. Goldstein and collaborators at the Center for Disease Control in Atlanta reviewed 25 years of data gathered from records of the emergency room of Charity Hospital in New Orleans as well as records of what cargoes had been handled in the port and found that the soybean loading there had also been responsible for the long-unexplained and severe epidemics. Dr Sunyer, currently Co-Director of the Centre for Research on Environmental Epidemiology and Director of the Research Program on Environmental Epidemiology at the Municipal Institute for Medical Research—both research centers in Europe—says, “Dr Goldstein was one of the first searching for the role of the urban indoor and outdoor air in asthma.” A researcher and an author Having worked in several fields of science, Dr. Goldstein has become aware that not only students and the general public but even many scientists need a better understanding of general scientific concepts. Together with her husband Dr. Martin Goldstein, a professor of chemistry, she has written 4 books with this purpose. They include How We Know: An Exploration of the Scientific Process and The Experience of Science: An Interdisciplinary Approach (Plenum Press 1978 and 1984) dealing with the methods and processes of science in general, How Much Risk (Oxford, 2002), which uses case studies to illustrate basic principles of environmental epidemiology, and The Refrigerator and the Universe (Harvard,

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1993), which explains the concepts of energy and entropy. All are still in print. Dr. Goldstein is currently collaborating with colleagues in the Department of Environmental Health Sciences (EHS) on studies that use novel biomarkers to increase the accuracy and precision of exposure assessment of agents that are suspected of playing a role both in the high prevalence of asthma in the inner-city areas of New York City and in the exacerbation of its symptoms. They are also seeking to detect the biological effects of such agents. Those who work with her fully appreciate how her earlier research has laid the groundwork for these studies. Says Dr. Matthew Perzanowski, an Associate Professor in EHS who works on the NYC Neighborhood Asthma and Allergy Study with Dr. Goldstein, “In many ways, we’re still investigating the risks of the things she was looking at 30 years ago.”

FACULTY ARTICLE BIBLIOGRAPHY NOVEMBER – DECEMBER 2011 LISTED ALPHABETICALLY BY FIRST AUTHOR Abdool Karim SS, Abdool Karim Q. Antiretroviral prophylaxis: a defining moment in HIV control. Lancet 2011 Published online July 15, 2011 DOI:10.1016/S01406736(11)61136-7 (published 17 July) Abdool Karim SS, Kashuba A, Werner L, Abdool Karim Q. Drug concentrations following topical and oral antiretroviral pre-exposure prophylaxis: Implications for HIV prevention in women. Lancet 2011 378: 279-281. (published 16 July) Abdool Karim SS, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q. Integration of antiretroviral therapy with tuberculosis treatment. N Engl J Med. 2011;365(16):1492-501. PMID: 22010915 Agnew A, Frucht SJ, Louis ED. Supine head tremor: a clinical comparison of essential tremor and spasmodic torticollis patients. J Neurol Neurosurg Psychiatry. 2011 Nov 5. [Epub ahead of print]. PMID: 22056962 Aigner M, Treasure J, Kaye W, Kasper S. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of eating disorders. World J Biol Psychiatry. 2011;12(6):400-43. PMID: 21961502 Antao VC, Pallos LL, Shim YK, Sapp JH, Brackbill RM, Cone JE, Stellman SD, Farfel MR. Respiratory protective equipment, mask use, and respiratory outcomes among World Trade Center rescue and recovery workers. Am J Ind Med. 2011 Sep 19. [Epub ahead of print]. PMID: 21932428 Apte M, Neidell M, Yoko Furuya E, Caplan D, Glied S, Larson E. Using Electronically Available Inpatient Hospital Data for Research. Clin Transl Sci. 2011;4(5):338-345. PMID: 22029805 Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, , , Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O’Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Sep 25. [Epub ahead of print]. PMID: 21946350

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Ayalon L, Gross R, Yaari A, Feldhamer E, Balicer R, Goldfracht M. Characteristics associated with purchasing antidepressant or antianxiety medications through primary care in Israel. Psychiatr Serv. 2011;62(9):1041-6. PMID: 21885582 Ayalon L, Gross R, Yaari A, Feldhamer E, Balicer RD, Goldfracht M. Disparities in antidepressant adherence in primary care: report from Israel. Am J Manag Care. 2011;17(9):e340-7. PMID: 21902441 Ayalon L, Gross R, Yaari A, Feldhamer E, Balicer RD, Goldfracht M. Patients’ and Physicians’ Characteristics Associated with the Purchase of Benzodiazepines by Older Primary Care Patients in Israel. Adm Policy Ment Health. 2011 Oct 21. [Epub ahead of print]. PMID: 22015399 Barr RG, Ahmed FS, Carr JJ, Hoffman EA, Jiang R, Kawut SM, Watson K. Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA lung study. Eur Respir J. 2011 Oct 27. [Epub ahead of print]. PMID: 22034646 Barr RG. The epidemiology of vascular dysfunction relating to chronic obstructive pulmonary disease and emphysema. Proc Am Thorac Soc. 2011;8(6):522-7. PMID: 22052931 Baumeister E, Palacios G, Cisterna D, Solovyov A, Hui J, Savji N, Bussetti AV, Campos A, Pontoriero A, Jabado OJ, Street C, Hirschberg DL, Rabadan R, Alonio V, Molina V, Hutchison S, Egholm M, Lipkin WI. Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina. Medicina (B Aires). 2010;70(6):51823. PMID: 21163739 Benke KS, Carlson MC, Doan BQ, Walston JD, Xue QL, Reiner AP, Fried LP, Arking DE, Chakravarti A, Fallin MD. The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study. Exp Gerontol. 2011 Sep 24. [Epub ahead of print]. PMID: 21968104 Blacksher E, Lovasi GS. Place-focused physical activity research, human agency, and social justice in public health: Taking agency seriously in studies of the built environment. Health Place. 2011 Sep 10. [Epub ahead of print]. PMID: 21940195 Blanco C, Vesga-López O, Stewart JW, Liu SM, Grant BF, Hasin DS. Epidemiology of major depression with atypical features: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry. 2011 Sep 6. [Epub ahead of print]. PMID: 21939615 Braunstein SL, Ingabire CM, Geubbels E, Vyankandondera J, Umulisa MM, Gahiro E, Uwineza M, Tuijn CJ, Nash D, van de Wijgert JH. High Burden of Prevalent and Recently Acquired HIV among Female Sex Workers and Female HIV Voluntary Testing Center Clients in Kigali, Rwanda. PLoS One. 2011;6(9):e24321. PMID: 21949704 Bussetti AV, Palacios G, Travassos da Rosa A, Savji N, Jain K, Guzman H, Hutchison S, Popov VL, Tesh RB, Lipkin WI. Genomic and antigenic characterization of Jos virus. J Gen Virol. 2011 Oct 12. [Epub ahead of print]. PMID: 21994326 Chace C, Pang D, Weng C, Temkin A, Lax S, Silverman W, Zigman W, Ferin M, Lee JH, Tycko B, Schupf N. Variants in CYP17 and CYP19 Cytochrome P450 Genes are Associated with Onset of Alzheimer’s Disease in Women with Down Syndrome. J Alzheimers Dis. 2011 Nov 4. [Epub ahead of print]. PMID: 22057025 Chajès V, Biessy C, Byrnes G, Deharveng G, SaadatianElahi M, Jenab M, Peeters PH, Ocké M, Bueno-deMesquita HB, Johansson I, Hallmans G, Manjer J, Wirfält E, Jakszyn P, González CA, Huerta JM, Martinez C, Amiano P, Suárez LR, Ardanaz E, Tjønneland A, Halkjaer J, Overvad K, Jakobsen MU, Berrino F, Pala V, Palli D, Tumino R, Vineis P, de Magistris MS, Spencer EA, Crowe FL, Bingham S, Khaw KT, Linseisen J, Rohrmann S, Boeing H, Nöethlings U, Olsen KS, Skeie G, Lund E, Trichopoulou A, Zilis D, Oustoglou E, Clavel-Chapelon F, Riboli E, Slimani N. Ecological-Level Associations Between Highly Processed Food Intakes and Plasma Phospholipid Elaidic Acid Concentrations: Results From a Cross-Sectional Study Within the European Prospective Investigation Into Cancer and Nutrition (EPIC). Nutr Cancer. 2011 Nov 1. [Epub ahead of print]. PMID: 22043987

Chajès V, Jenab M, Romieu I, Ferrari P, Dahm CC, Overvad K, Egeberg R, Tjønneland A, Clavel-Chapelon F, Boutron-Ruault MC, Engel P, Teucher B, Kaaks R, Floegel A, Boeing H, Trichopoulou A, Dilis V, Karapetyan T, Mattiello A, Tumino R, Grioni S, Palli D, Vineis P, Bueno-de-Mesquita HB, Numans ME, Peeters PH, Lund E, Navarro C, Quirós JR, Sánchez-Cantalejo E, Gurrea AB, Dorronsoro M, Regnér S, Sonestedt E, Wirfält E, Khaw KT, Wareham N, Allen NE, Crowe FL, Rinaldi S, Slimani N, Carneiro F, Riboli E, González CA. Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Am J Clin Nutr. 2011 Oct 12. [Epub ahead of print]. PMID: 21993438 Chang R, Todd Greene M, Chenoweth CE, Kuhn L, Shuman E, Rogers MA, Saint S. Epidemiology of hospital-acquired urinary tract-related bloodstream infection at a university hospital. Infect Control Hosp Epidemiol. 2011;32(11):11279. PMID: 22011543 Cleveland RJ, Eng SM, Stevens J, Bradshaw PT, Teitelbaum SL, Neugut AI, Gammon MD. Influence of prediagnostic recreational physical activity on survival from breast cancer. Eur J Cancer Prev. 2011 Sep 22. [Epub ahead of print]. PMID: 21946863 Conway LJ, Larson EL. Guidelines to prevent catheterassociated urinary tract infection: 1980 to 2010. Heart Lung. 2011 Sep 17. [Epub ahead of print]. PMID: 21925731 Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C, Greene MH, Mai PL, Andrulis IL, , Thomassen M, Gerdes AM, Caligo MA, Friedman E, Laitman Y, Kaufman B, Paluch SS, Borg A, Karlsson P, Askmalm MS, Bustinza GB, , Nathanson K, Domchek SM, Rebbeck TR, Benítez J, Hamann U, Rookus MA, van den Ouweland AM, Ausems MG, Aalfs CM, van Asperen CJ, Devilee P, Gille H, Peock S, Frost D, Evans DG, Eeles R, Izatt L, Adlard J, Paterson J, Eason J, Godwin AK, Remon MA, Moncoutier V, GauthierVillars M, Lasset C, Giraud S, Hardouin A, Berthet P, Sobol H, Eisinger F, Paillerets BB, Caron O, Delnatte C, , Goldgar D, Miron A, Ozcelik H, Buys S, Southey MC, Terry MB, Singer CF, Dressler AC, Tea MK, Hansen TV, Johannsson O, Piedmonte M, Rodriguez GC, Basil JB, Blank S, Toland AE, Montagna M, Isaacs C, Blanco I, Gayther SA, Moysich KB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Sutter C, Gadzicki D, Fiebig B, Caldes T, Laframboise R, Nevanlinna H, Chen X, Beesley J, Spurdle AB, Neuhausen SL, Ding YC, Couch FJ, Wang X, Peterlongo P, Manoukian S, Bernard L, Radice P, Easton DF, Chenevix-Trench G, Antoniou AC, StoppaLyonnet D, Mazoyer S, Sinilnikova OM. Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Hum Mol Genet. 2011 Sep 2. [Epub ahead of print]. PMID: 21890493 Coylewright M, Rice K, Budoff MJ, Blumenthal RS, Greenland P, Kronmal R, Barr RG, Burke GL, Tracy R, Post WS. Differentiation of severe coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2011 Aug 31. [Epub ahead of print]. PMID: 21930271 Cule E, Vineis P, De Iorio M. Significance testing in ridge regression for genetic data. BMC Bioinformatics. 2011;12(1):372. PMID: 21929786 Debchoudhury I, Welch AE, Fairclough MA, Cone JE, Brackbill RM, Stellman SD, Farfel MR. Comparison of health outcomes among affiliated and lay disaster volunteers enrolled in the World Trade Center Health Registry. Prev Med. 2011 Sep 10. [Epub ahead of print]. PMID: 21930152 Desai M, Esserman DA, Gammon MD, Terry MB. The use of complete-case and multiple imputation-based analyses in molecular epidemiology studies that assess interaction effects. Epidemiol Perspect Innov. 2011;8(1):5. PMID: 21978450 Drumright LN, Hagan H, Thomas DL, Latka MH, Golub ET, Garfein RS, Clapp JD, Campbell JV, Bonner S, Kapadia F, Thiel TK, Strathdee SA. Predictors and effects of alcohol use on liver function among young HCV-infected injection drug users in a behavioral intervention. J Hepatol. 2011;55(1):45-52. PMID: 21145862

Dunn EC, Uddin M, Subramanian SV, Smoller JW, Galea S, Koenen KC. Research Review: Gene-environment interaction research in youth depression—a systematic review with recommendations for future research. J Child Psychol Psychiatry. 2011 Sep 29. [Epub ahead of print]. PMID: 21954964

Romaguera D, Bueno-de-Mesquita HB, Kaaks R. Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia. 2011 Sep 28. [Epub ahead of print]. PMID: 21953276

Eckel SP, Bandeen-Roche K, Chaves PH, Fried LP, Louis TA. Surrogate screening models for the low physical activity criterion of frailty. Aging Clin Exp Res. 2011;23(3):209-16. PMID: 21993168

Grov C, Hirshfield S, Remien RH, Humberstone M, Chiasson MA. Exploring the Venue’s Role in Risky Sexual Behavior Among Gay and Bisexual Men: An Event-Level Analysis from a National Online Survey in the U.S. Arch Sex Behav. 2011 Oct 20. [Epub ahead of print]. PMID: 22012413

El-Sadr WM, Coburn BJ, Blower SM. Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission. AIDS. 2011 Oct 11. [Epub ahead of print]. PMID: 21993304 Essue B, Kelly P, Roberts M, Leeder S, Jan S. We can’t afford my chronic illness! The out-of-pocket burden associated with managing chronic obstructive pulmonary disease in western Sydney, Australia. J Health Serv Res Policy. 2011 Sep 27. [Epub ahead of print]. PMID: 21954233 Flom JD, Ferris JS, Liao Y, Tehranifar P, Belessiotis Richards C, Cho YH, Gonzalez K, Santella RM, Terry MB. Prenatal Smoke Exposure and Genomic DNA Methylation in a Multiethnic Urban Birth Cohort. Cancer Epidemiol Biomarkers Prev. 2011 Oct 12. [Epub ahead of print]. PMID: 21994404 Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P. Strengthening the Reporting of Observational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement. Prev Med. 2011 Oct 21. [Epub ahead of print]. PMID: 22029945 Gelpi-Acosta C, Hagan H, Jenness SM, Wendel T, Neaigus A. Sexual and Injection-Related Risks in Puerto Rican-Born Injection Drug Users Living in New York City: A Mixed-Methods Analysis. Harm Reduct J. 2011;8(1):28. PMID: 22004801 Geng EH, Hunt PW, Diero LO, Kimaiyo S, Somi GR, Okong P, Bangsberg DR, Bwana MB, Cohen CR, Otieno JA, Wabwire D, Elul B, Nash D, Easterbrook PJ, Braitstein P, Musick BS, Martin JN, Yiannoutsos CT, Wools-Kaloustian K. Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009. J Int AIDS Soc. 2011;14(1):46. PMID: 21955541 Goodwin RD, Marusic A. Perception of Health, Suicidal Ideation, and Suicide Attempt Among Adults in the Community. Crisis. 2011 Sep 26;:1-6. PMID: 21945842 Goodwin RD, Wamboldt FS. Childhood Physical Abuse and Respiratory Disease in the Community: The Role of Mental Health and Cigarette Smoking. Nicotine Tob Res. 2011 Oct 24. [Epub ahead of print]. PMID: 22025544 Goral A, Lipsitz JD, Muhsen K, Gross R. Depressive symptoms, risk factors and sleep in asthma: results from a national Israeli health survey. Gen Hosp Psychiatry. 2011 Oct 20. [Epub ahead of print]. PMID: 22018770 Granich R, Gupta S, Suthar AB, Smyth C, Hoos D, Vitoria M, Bavicchi Simao M, Hankins C, Schwartlander B, Ridzon R, Bazin B, Williams B, Lo YR, McClure C, Montaner J, Hirnschall G. Antiretrovirals therapy in Prevention of HIV and TB: Update on Current Research Efforts. Curr HIV Res. 2011 Oct 14. [Epub ahead of print]. PMID: 21999779 Greenlee H, Kwan ML, Kushi LH, Song J, Castillo A, Weltzien E, Quesenberry CP, Caan BJ. Antioxidant supplement use after breast cancer diagnosis and mortality in the Life After Cancer Epidemiology (LACE) cohort. Cancer. 2011 Sep 27. [Epub ahead of print]. PMID: 21953120 Grote VA, Rohrmann S, Nieters A, Dossus L, Tjønneland A, Halkjær J, Overvad K, Fagherazzi G, Boutron-Ruault MC, Morois S, Teucher B, Becker S, Sluik D, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Pala V, Tumino R, Vineis P, Panico S, Rodríguez L, Duell EJ, Molina-Montes E, Dorronsoro M, Huerta JM, Ardanaz E, Jeurnink SM, Beulens JW, Peeters PH, Sund M, Ye W, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen N, Crowe F, Jenab M, Romieu I, Michaud DS, Riboli E,

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Hamshere ML, O’Donovan MC, Jones IR, Jones L, Kirov G, Green EK, Moskvina V, Grozeva D, Bass N, McQuillin A, Gurling H, St Clair D, Young AH, Ferrier IN, Farmer A, McGuffin P, Sklar P, Purcell S, Holmans PA, Owen MJ, Craddock N. Polygenic dissection of the bipolar phenotype. Br J Psychiatry. 2011;198:284-8. PMID: 21972277 Hankerson SH, Fenton MC, Geier TJ, Keyes KM, Weissman MM, Hasin DS. Racial differences in symptoms, comorbidity, and treatment for major depressive disorder among black and white adults. J Natl Med Assoc. 2011 Jul;103(7):576-84. PMID: 21999032 Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP, Investigators C. The clinical features of the overlap between COPD and asthma. Respir Res. 2011;12(1):127. PMID: 21951550 Hasin D, Fenton MC, Skodol A, Krueger R, Keyes K, Geier T, Greenstein E, Blanco C, Grant B. Personality disorders and the 3-year course of alcohol, drug, and nicotine use disorders. Arch Gen Psychiatry. 2011;68(11):1158-67. PMID: 22065531 Hasin DS, Fenton MC, Beseler C, Park JY, Wall MM. Analyses related to the development of DSM-5 criteria for substance use related disorders: 2. Proposed DSM-5 criteria for alcohol, cannabis, cocaine and heroin disorders in 663 substance abuse patients. Drug Alcohol Depend. 2011 Sep 30. [Epub ahead of print]. PMID: 21963333 Heilig CM, Chia D, El-Sadr WM, Hirsch-Moverman Y, Kenzie WR, Saukkonen J, Villarino ME, Padayatchi N. Justifying research risks in a clinical trial for treatment of multidrug-resistant tuberculosis. IRB. 2011;33(4):10-7. PMID: 21932482 Hesdorffer D, Beghi E.ILAE epidemiology commission report: introduction to the supplement. Epilepsia. 2011;52 Suppl 7:1. PMID: 22010261 Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N, Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass NJ, Gurling H, McQuillin A, Holmans P, Jones L, Devlin B, Klei L, Barmada MM, Demirci FY, Dekosky ST, Lopez OL, Passmore P, Owen MJ, O’Donovan MC, Mayeux R, Kamboh MI, Williams J. Genome-wide association study of Alzheimer’s disease with psychotic symptoms. Mol Psychiatry. 2011 Oct 18. [Epub ahead of print]. PMID: 22005930 Hua M, Brady J, Li G. The Epidemiology of Upper Airway Injury in Patients Undergoing Major Surgical Procedures. Anesth Analg. 2011 Nov 3. [Epub ahead of print]. PMID: 22052982 Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA. Immune Activation in the Female Genital Tract During HIV Infection Predicts Mucosal CD4 Depletion and HIV Shedding. J Infect Dis. 2011 Sep 21. [Epub ahead of print]. PMID: 21940422 Jina R, Jewkes R, Hoffman S, Dunkle KL, Nduna M, Shai NJ. Adverse Mental Health Outcomes Associated With Emotional Abuse in Young Rural South African Women: A Cross-Sectional Study. J Interpers Violence. 2011 Oct 10. [Epub ahead of print]. PMID: 21987516 Jordan HT, Miller-Archie SA, Cone JE, Morabia A, Stellman SD. Heart disease among adults exposed to the September 11, 2001 World Trade Center disaster: Results from the World Trade Center Health Registry. Prev Med. 2011 Oct 28. [Epub ahead of print]. PMID: 22040652

Kapogiannis BG, Soe MM, Nesheim SR, Abrams EJ, Carter RJ, Farley J, Palumbo P, Koenig LJ, Bulterys M. Mortality Trends in the US Perinatal AIDS Collaborative Transmission Study (1986-2004). Clin Infect Dis. 2011;53(10):1024-34. PMID: 22002982 Kapoor A, Mehta N, Dubovi EJ, Simmonds P, Govindasamy L, Medina JL, Street C, Shields S, Lipkin WI. Characterization of Novel Canine Bocaviruses and their Association with Respiratory Disease. J Gen Virol. 2011 Oct 26. [Epub ahead of print]. PMID: 22031527 Kelvin EA, Mantell JE, Cendelario N, Hoffman S, Exner TM, Stackhouse W, Stein ZA. Off-Label Use of the Female Condom for Anal Intercourse Among Men in New York City. Am J Public Health. 2011 Oct 20. [Epub ahead of print]. PMID: 22021299 Keyes KM, Li G, Hasin DS. Birth Cohort Effects and Gender Differences in Alcohol Epidemiology: A Review and Synthesis. Alcohol Clin Exp Res. 2011 Sep 15. [Epub ahead of print]. PMID: 21919918 Keyes KM, Liu XC, Cerdá M. The Role of Race/Ethnicity in Alcohol-attributable Injury in the United States. Epidemiol Rev. 2011 Sep 19. [Epub ahead of print]. PMID: 21930592 Keyes KM, McLaughlin KA, Koenen KC, Goldmann E, Uddin M, Galea S. Child maltreatment increases sensitivity to adverse social contexts: Neighborhood physical disorder and incident binge drinking in Detroit. Drug Alcohol Depend. 2011 Oct 5. [Epub ahead of print]. PMID: 21981990 Koblin BA, Casapia M, Morgan C, Qin L, Wang ZM, Defawe OD, Baden L, Goepfert P, Tomaras GD, Montefiori DC, McElrath MJ, Saavedra L, Lau CY, Graham BS. Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial. PLoS One. 2011;6(9):e24517. PMID: 21931737 Kuo SH, Erickson-Davis C, Gillman A, Faust PL, Vonsattel JP, Louis ED. Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry. 2011;82(9):1038-40. PMID: 20802031 Lebwohl B, Hassid B, Ludwin S, Lewis SK, Tennyson CA, Neugut AI, Green PH. Increased Sedation Requirements During Endoscopy in Patients with Celiac Disease. Dig Dis Sci. 2011 Nov 4. [Epub ahead of print]. PMID: 22052448 Leenders M, Chuang SC, Dahm CC, Overvad K, Ueland PM, Midttun O, Vollset SE, Tjønneland A, Halkjaer J, Jenab M, Clavel-Chapelon F, Boutron-Ruault MC, Kaaks R, Canzian F, Boeing H, Weikert C, Trichopoulou A, Bamia C, Naska A, Palli D, Pala V, Mattiello A, Tumino R, Sacerdote C, Duijnhoven FJ, Peeters PH, Gils CH, Lund E, Rodriguez L, Duell EJ, Pérez MJ, Molina-Montes E, Castaño JM, Barricarte A, Larrañaga N, Johansen D, Lindkvist B, Sund M, Ye W, Khaw KT, Wareham NJ, Michaud DS, Riboli E, Xun WW, Allen NE, Crowe FL, Bueno-de-Mesquita HB, Vineis P. Plasma cotinine levels and pancreatic cancer in the EPIC cohort study. Int J Cancer. 2011 Sep 22. [Epub ahead of print]. PMID: 21953524 Li C, Xu J, Li F, Chaudhary SC, Weng Z, Wen J, Elmets CA, Ahsan H, Athar M. Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenicinduced cutaneous inflammation. Cancer Prev Res (Phila). 2011 Sep 12. [Epub ahead of print]. PMID: 21911445 Li MC, Brady JE, Dimaggio CJ, Lusardi AR, Tzong KY, Li G. Marijuana Use and Motor Vehicle Crashes. Epidemiol Rev. 2011 Oct 4. [Epub ahead of print]. PMID: 21976636 Lipkin WI, Briese T, Hornig M. Borna disease virus—Fact and fantasy. Virus Res. 2011 Oct 1. [Epub ahead of print]. PMID: 21968299 Livaudais JC, Hershman DL, Habel L, Kushi L, Gomez SL, Li CI, Neugut AI, Fehrenbacher L, Thompson B, Coronado GD. Racial/ethnic differences in initiation of adjuvant hormonal therapy among women with hormone receptor-positive breast cancer. Breast Cancer Res Treat. 2011 Sep 16. [Epub ahead of print]. PMID: 21922245

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Schneier FR, Neria Y, Pavlicova M, Hembree E, Suh EJ, Amsel L, Marshall RD. Combined Prolonged Exposure Therapy and Paroxetine for PTSD Related to the World Trade Center Attack: A Randomized Controlled Trial. Am J Psychiatry. 2011 Sep 9. [Epub ahead of print]. PMID: 21908494 Scoccianti C, Minelli L, Biribanti A, Casadei R, Vineis P. [Environment and health: the case of the built environment and obesity]. Ig Sanita Pubbl. 2011;67(3):339-50. PMID: 22033162 Sharma C, Deutsch I, Horowitz DP, Hershman DL, Lewin SN, Lu YS, Neugut AI, Herzog TJ, Chao CK, Wright JD. Patterns of care and treatment outcomes for elderly women with cervical cancer. Cancer. 2011 Oct 28. [Epub ahead of print]. PMID: 22038773 Shulman EP, Cauffman E, Piquero AR, Fagan J. Moral disengagement among serious juvenile offenders: A longitudinal study of the relations between morally disengaged attitudes and offending. Dev Psychol. 2011 Sep 12. [Epub ahead of print]. PMID: 21910534 Sibeko S, Baxter C, Yende N, Abdool Karim Q, Abdool Karim SS, on behalf of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 Trial Group. Contraceptive Choices, Pregnancy Rates, and Outcomes in a Microbicide Trial. Obstet Gynecol 2011; 118: 895-904. (published in Oct issue) Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, Kwan P, Wienker TF, Daly M, Dudbridge F, Holmans PA, Lin D, Burmeister M, Greenwood TA, Hamshere ML, Muglia P, Smith EN, Zandi PP, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Bloss CS, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Schulze TG, Berrettini W, Lohoff FW, Potash JB, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Breuer R, Meier S, Strohmaier J, Witt SH, Tozzi F, Farmer A, McGuffin P, Strauss J, Xu W, Kennedy JL, Vincent JB, Matthews K, Day R, Ferreira MA, O’Dushlaine C, Perlis R, Raychaudhuri S, Ruderfer D, Hyoun PL, Smoller JW, Li J, Absher D, Thompson RC, Meng FG, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Watson SJ, Myers RM, Akil H, Boehnke M, Chambert K, Moran J, Scolnick E, Djurovic S, Melle I, Morken G, Gill M, Morris D, Quinn E, Mühleisen TW, Degenhardt FA, Mattheisen M, Schumacher J, Maier W, Steffens M, Propping P, Nöthen MM, Anjorin A, Bass N, Gurling H, Kandaswamy R, Lawrence J, McGhee K, McIntosh A, McLean AW, Muir WJ, Pickard BS, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Jones IR, Kirov G, Moskvina V, Nikolov I, O’Donovan MC, Owen MJ, Collier DA, Elkin A, Williamson R, Young AH, Ferrier IN, Stefansson K, Stefansson H, Thornorgeirsson T, Steinberg S, Gustafsson O, Bergen SE, Nimgaonkar V, Hultman C, Landén M, Lichtenstein P, Sullivan P, Schalling M, Osby U, Backlund L, Frisén L, Langstrom N, Jamain S, Leboyer M, Etain B, Bellivier F, Petursson H, Sigur Sson E, Müller-Mysok B, Lucae S, Schwarz M, Schofield PR, Martin N, Montgomery GW, Lathrop M, Oskarsson H, Bauer M, Wright A, Mitchell PB, Hautzinger M, Reif A, Kelsoe JR, Purcell SM. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18. [Epub ahead of print]. PMID: 21926972 Smith BD, Teshale E, Jewett A, Weinbaum CM, Neaigus A, Hagan H, Jenness SM, Melville SK, Burt R, Thiede H, Al-Tayyib A, Pannala PR, Miles IW, Oster AM, Smith A, Finlayson T, Bowles KE, Dinenno EA. Performance of premarket rapid hepatitis C virus antibody assays in 4 national human immunodeficiency virus behavioral surveillance system sites. Clin Infect Dis. 2011;53(8):780-6. PMID: 21921221 Stanekzai MR, Todd CS, Orr MG, Bayan S, Rasuli MZ, Wardak SR, Strathdee SA. Baseline assessment of community knowledge and attitudes toward drug use and harm reduction in Kabul, Afghanistan. Drug Alcohol Rev. 2011 Sep 15. [Epub ahead of print]. PMID: 21919980

Tatemichi TK, Desmond DW, Mayeux R, Paik M, Stern Y, Sano M, Remien RH, Williams JB, Mohr JP, Hauser WA, Figueroa M. Dementia after stroke: Baseline frequency, risks, and clinical features in a hospitalized cohort. Neurology. 2011;77(17):1610. PMID: 22025458 Terry MB, Knight JA. STROBE-ME—Illuminating methodological issues for the reporting of molecular epidemiology data. Prev Med. 2011 Oct 15. [Epub ahead of print]. PMID: 22024220 Thorpe LE, Friedman S. Health Consequences of the World Trade Center Disaster: A 10th Anniversary Perspective. JAMA. 2011 Sep 8. [Epub ahead of print]. PMID: 21903819 Thurman DJ, Beghi E, Begley CE, Berg AT, Buchhalter JR, Ding D, Hesdorffer DC, Hauser WA, Kazis L, Kobau R, Kroner B, Labiner D, Liow K, Logroscino G, Medina MT, Newton CR, Parko K, Paschal A, Preux PM, Sander JW, Selassie A, Theodore W, Tomson T, Wiebe S. Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 2011;52 Suppl 7:2-26. PMID: 21899536 Tiffany ST, Friedman L, Greenfield SF, Hasin DS, Jackson R. Beyond drug use: a systematic consideration of other outcomes in evaluations of treatments for substance use disorders. Addiction. 2011 Oct 7. [Epub ahead of print]. PMID: 21981638 Travier N, Agudo A, May AM, Gonzalez C, Luan J, Wareham NJ, Bueno-de-Mesquita HB, van den Berg SW, Slimani N, Rinaldi S, Clavel-Chapelon F, Boutron-Ruault MC, Palli D, Sieri S, Mattiello A, Tumino R, Vineis P, Norat T, Romaguera D, Rodriguez L, Sanchez MJ, Dorronsoro M, Barricarte A, Huerta JM, Key TJ, Orfanos P, Naska A, Trichopoulou A, Rohrmann S, Kaaks R, Bergmann MM, Boeing H, Hallmans G, Johansson I, Manjer J, Lindkvist B, Jakobsen MU, Overvad K, Tjonneland A, Halkjaer J, Lund E, Braaten T, Odysseos A, Riboli E, Peeters PH. Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study. Prev Med. 2011 Sep 12. [Epub ahead of print]. PMID: 21939684 Uchida M, Stone PW, Conway LJ, Pogorzelska M, Larson EL, Raveis VH. Exploring infection prevention: policy implications from a qualitative study. Policy Polit Nurs Pract. 2011;12(2):82-9. PMID: 22042614 Vieira JR, Elkind MS, Moon YP, Rundek T, Boden-Albala B, Paik MC, Sacco RL, Wright CB. The Metabolic Syndrome and Cognitive Performance: The Northern Manhattan Study. Neuroepidemiology. 2011;37(3-4):153-159. PMID: 22005335 Vlahov D, Agarwal SR, Buckley RM, Caiaffa WT, Corvalan CF, Ezeh AC, Finkelstein R, Friel S, Harpham T, Hossain M, de Faria Leao B, Mboup G, Montgomery MR, Netherland JC, Ompad DC, Prasad A, Quinn AT, Rothman A, Satterthwaite DE, Stansfield S, Watson VJ. Roundtable on Urban Living Environment Research (RULER). J Urban Health. 2011 Sep 12. [Epub ahead of print]. PMID: 21910089 Weiss CO, Wolff JL, Egleston B, Seplaki CL, Fried LP. Incident preclinical mobility disability (PCMD) increases future risk of new difficulty walking and reduction in walking activity. Arch Gerontol Geriatr. 2011 Sep 22. [Epub ahead of print]. PMID: 21944428 Williams BL, Hornig M, Buie T, Bauman ML, Cho Paik M, Wick I, Bennett A, Jabado O, Hirschberg DL, Lipkin WI. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011;6(9):e24585. PMID: 21949732 Wright JD, Hershman DL, Burke WM, Lu YS, Neugut AI, Lewin SN, Herzog TJ. Influence of Surgical Volume on Outcome for Laparoscopic Hysterectomy for Endometrial Cancer. Ann Surg Oncol. 2011 Oct 12. [Epub ahead of print]. PMID: 21989660 Wright JD, Hershman DL, Shah M, Burke WM, Sun X, Neugut AI, Lewin SN, Herzog TJ. Quality of perioperative venous thromboembolism prophylaxis in gynecologic surgery. Obstet Gynecol. 2011;118(5):978-86. PMID: 22015864

Wright JD, Lewin SN, Deutsch I, Burke WM, Sun X, Neugut AI, Herzog TJ, Hershman DL. Defining the limits of radical cytoreductive surgery for ovarian cancer. Gynecol Oncol. 2011 Sep 27. [Epub ahead of print]. PMID: 21958535 Wu X, Scelo G, Purdue MP, Rothman N, Johansson M, Ye Y, Wang Z, Zelenika D, Moore LE, Wood CG, Prokhortchouk E, Gaborieau V, Jacobs KB, Chow WH, Toro JR, Zaridze D, Lin J, Lubinski J, Trubicka J, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Jinga V, Bencko V, Slamova A, Holcatova I, Navratilova M, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL, Boeing H, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno-deMesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Virtamo J, Vatten L, Hveem K, Fletcher T, Koppova K, Cussenot O, Cancel-Tassin G, Benhamou S, Hildebrandt MA, Pu X, Foglio M, Lechner D, Hutchinson A, Yeager M, Fraumeni JF, Lathrop M, Skryabin KG, McKay JD, Gu J, Brennan P, Chanock SJ. A genomewide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet. 2011 Oct 18. [Epub ahead of print]. PMID: 22010048 Xu Q, Paik MC, Rundek T, Elkind MS, Sacco RL. Reweighting estimators for Cox regression with missing covariate data: Analysis of insulin resistance and risk of stroke in the Northern Manhattan Study. Stat Med. 2011 Oct 3. [Epub ahead of print]. PMID: 21965165 Xu X, Gammon MD, Jefferson E, Zhang Y, Cho YH, Wetmur JG, Teitelbaum SL, Bradshaw PT, Terry MB, Garbowski G, Hibshoosh H, Neugut AI, Santella RM, Chen J. The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study. Epigenetics. 2011;6(11). PMID: 22048254 Yaddanapudi K, De Miranda J, Hornig M, Lipkin WI. Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway. PLoS One. 2011;6(10):e26766. PMID: 22046349 Yang LH, Singla DR. Use of indigenous cultural idioms by chinese immigrant relatives for psychosis: impacts on stigma and psychoeducational approaches. J Nerv Ment Dis. 2011;199(11):872-8. PMID: 22048140 Young Park J, Nicolas G, Freisling H, Biessy C, Scalbert A, Romieu I, Chajès V, Chuang SC, Ericson U, Wallström P, Ros MM, Peeters PH, Mattiello A, Palli D, María Huerta J, Amiano P, Halkjær J, Dahm CC, Trichopoulou A, Orfanos P, Teucher B, Feller S, Skeie G, Engeset D, Boutron-Ruault MC, Clavel-Chapelon F, Crowe F, Khaw KT, Vineis P, Slimani N. Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition. Br J Nutr. 2011;:1-18. PMID: 22040523

Zeki Al Hazzouri A, Haan MN, Galea S, Aiello AE. Lifecourse exposure to early socioeconomic environment, education in relation to late-life cognitive function among older mexicans and mexican americans. J Aging Health. 2011;23(7):1027-49. PMID: 21948769 Zesiewicz TA, Elble RJ, Louis ED, Gronseth GS, Ondo WG, Dewey RB, Okun MS, Sullivan KL, Weiner WJ. Evidencebased guideline update: Treatment of essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2011 Oct 19. [Epub ahead of print]. PMID: 22013182 Xu X, Gammon MD, Jefferson E, Zhang Y, Cho YH, Wetmur JG, Teitelbaum SL, Bradshaw PT, Terry MB, Garbowski G, Hibshoosh H, Neugut AI, Santella RM, Chen J. The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study. Epigenetics. 2011;6(11). PMID: 22048254 Yaddanapudi K, De Miranda J, Hornig M, Lipkin WI. Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway. PLoS One. 2011;6(10):e26766. PMID: 22046349 Yang LH, Singla DR. Use of indigenous cultural idioms by chinese immigrant relatives for psychosis: impacts on stigma and psychoeducational approaches. J Nerv Ment Dis. 2011;199(11):872-8. PMID: 22048140 Young Park J, Nicolas G, Freisling H, Biessy C, Scalbert A, Romieu I, Chajès V, Chuang SC, Ericson U, Wallström P, Ros MM, Peeters PH, Mattiello A, Palli D, María Huerta J, Amiano P, Halkjær J, Dahm CC, Trichopoulou A, Orfanos P, Teucher B, Feller S, Skeie G, Engeset D, Boutron-Ruault MC, Clavel-Chapelon F, Crowe F, Khaw KT, Vineis P, Slimani N. Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition. Br J Nutr. 2011;:1-18. PMID: 22040523 Zeki Al Hazzouri A, Haan MN, Galea S, Aiello AE. Lifecourse exposure to early socioeconomic environment, education in relation to late-life cognitive function among older mexicans and mexican americans. J Aging Health. 2011;23(7):1027-49. PMID: 21948769 Zesiewicz TA, Elble RJ, Louis ED, Gronseth GS, Ondo WG, Dewey RB, Okun MS, Sullivan KL, Weiner WJ. Evidencebased guideline update: Treatment of essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2011 Oct 19. [Epub ahead of print]. PMID: 22013182

TWO BY TWO Sandro Galea, MD, DrPH Gelman Professor and Chair Department of Epidemiology Editor

Barbara Aaron Administrative Director ASSOCIATE Editor / WRITER

Elaine Meyer Communications Coordinator Designer

Jon Kalish