Cardiovascular Research Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

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The VU University Medical Center (VUmc) has been established on January 1st 2001. This date marks the formal integration of the VU academic hospital and the Faculty of Medicine of VU University Amsterdam. The VUmc has identified Cardiovascular Research as one of the core research areas. the Institute for Cardiovascular Research (ICaR-VU) has taken the initiative to develop the Cardiovascular Research Master, an ideal environment to start a career in Cardiovascular Research at the highest level. The Master’s Programme was approved by the Dutch Ministry of Education, Culture and Science (OC&W) and started in 2009. The VUmc is responsible for the organization and coordination of the Cardiovascular Research Master. This includes quality assurance, programme development and student guidance. The prospectus of the Cardiovascular Research Master provides information on organization of the educational programme and descriptions of courses and other components that can be examined. Members of the programme committee are highly dedicated to the Master’s Programme. Students, VU/VUmc-staff members and other interested persons are welcome to contact us for any questions and suggestions in regard of the Master’s Programme. Names and addresses of the programme coordinator, programme committee, professors and student-representatives can be found at the end of this prospectus. Aim of the study programme Cardiovascular complications such as heart failure and stroke are the main causes of death in the Western world. Their incidences are still rising due to the aging of the population, obesity and, paradoxically, the successful treatment of acute myocardial infarction and cardiac arrhythmia. The acute occurrence/incidence of cardiac infarction, arrhythmia and stroke requires the restoration of vital functions in the human body with unduly delay. Research in order to prevent, diagnose and treat cardiovascular diseases is therefore of vital importance. This research master is focused on research questions aimed at the improvement of cardiac function in heart failure and the improvement of vascular function in metabolic diseases. Cardiovascular research is interdisciplinary by nature and flourishes by a close collaboration between clinical researchers and basic scientists. The clinical applications require background knowledge of physiology, anatomy, pathology, pharmacology and anaesthesiology as well as knowledge of the design of clinical trials and epidemiology. The interdisciplinary approach requires out of the box thinking and basic laboratory skills, combined with good communication with other scientists. During the courses and placements the intellectual attitude will be developed required to unravel mechanisms, their biological relevance and to find new therapeutics, in vitro, in animals and patients (from bench to bedside). Structure of organisation The Cardiovascular Research Master operate under the responsibility of the executive board of the VUmc (RvB). Within the VUmc, all educational activities are coordinated by the Institute of Education and Training (IET). The programme leader, and master coordinator of the Cardiovascular Research Master take care of the organisation and gearing of the curriculum. The Cardiovascular Research Master has his own programme committee and examination board. The programme committee advises the executive board of the VUmc, the director of the IET and the programme leader about the contents of the Master’s Programme and the quality of execution. The examination board decrees norms concerning admission of students, it makes sure that bachelors comply with the commencing norms, it decrees norms concerning examination of different subjects and it verifies the results of examinations, internships and the Master Thesis. Furthermore, the examination board evaluates the combinations of optional courses and internships of each individual student. All compulsory and optional courses are coordinated by different course coordinators. The composition of both the examination board and the programme committee is pointed out in Chapter 6 of the prospectus. General information about organisation, education, research and patient's care within VUmc can be found on the website of the VUmc. Dr. E. Kanters Coordinator Cardiovascular Research Master Telephone: +31 (0)20 444 58 95 E-mail: [email protected] Structure and contents Cardiovascular Research Master General The Cardiovascular Research Master aims to train (bio)medically-oriented bachelors and related bachelors in life Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

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sciences to become masters with in-depth knowledge, attitudes and skills in the field of cardiovascular research. This includes development, execution, organization and evaluation of cardiovascular scientific research. Duration of the programme is two years (120 credit points ECTS). One ECTS is equivalent to 28 hours of study load. Each item of examination that is finished successfully is equal to a given number of credit points. All credit points per study component are listed in this prospectus and in the Education and Examination Norms. In order to receive the degree of MSc in Cardiovascular research a student has to collect at least 120 ECTS credit-points. Tuition is in English. For more information, see the website of the Master’s Programme. Structure of the Master Cardiovascular Research The items that have to be assessed are compulsory courses, optional courses, a study of literature and two practical training periods (minor and major internships, 63 ECTS in total). These items all have their own code of administration. Each item will be assessed separately and students will receive final marks after completion. This final mark can be the result of an examination, report, or an oral presentation at the end of a course or it can be the result of partial marks, derived from more than one examination and/or practical assessments. It can also occur that attendance during lessons is one of the obligated conditions to successfully finish the course to be assessed. Only if the student meets all conditions, he/she will receive a final mark. The complete programme consists of all assessed items, which in practice means that all examinations will be added up to a total of 120 ECTS. The board of examiners will eventually decide whether the Master programme is completed successfully The Cardiovascular Research Master programme consists of the following items:

Item

ECTS

Compulsory courses

30

Optional courses

18

Internships: - Minor 21 ECTS - Major 36 ECTS

63

Study of literature

9

Total

120

Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

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Inhoudsopgave

Master Cardiovasc. Diverse activiteiten

1

Master Cardiovascular Research - Optional Courses

1

Master Cardiovascular Research - Compulsory Courses

1

Master Cardiovascular Research - Practical Training

2

Master Cardiovascular Research - Study of Literature

2

Vak: Advanced Cardiac Diagnostics

2

Vak: Biostatistics

3

Vak: Clinical and Biophysical Aspects of Cardiovascular Diseases and Imaging

4

Vak: Ethical Dimensions of Medical Research on Human Subjects

4

Vak: Extension Practical Training

5

Vak: Life Cell Imaging

5

Vak: Modelling and Simulation in Medical Natural Sciences

6

Vak: Pathophysiology of Heart and Circulation

7

Vak: Practical Training 1

7

Vak: Practical Training 2

7

Vak: Proteomics in Biomedical Research

8

Vak: Radiation Protection Course, Level 5B

8

Vak: Remodelling of the Circulatory System

9

Vak: Study of Literature

9

Vak: Vascular Function and Metabolic Diseases

10

Vak: Writing Scientific English

10

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Master Cardiovasc. Diverse activiteiten

Master Cardiovascular Research - Optional Courses The Cardiovascular Research Master has reserved 18 ECTS credit points for optional courses. The optional courses are listed underneath. These courses are approved by the examination board of the Cardiovascular Research Master and do not need individual student approvals. Additional optional courses will be announced on the blackboard site "Cardiovascular Research Master ". If a student wants to follow a course which is not indicated, an individual approval by the examination board is required. Some optional courses are organized together with or by other faculties, like FEW (Faculty of Exact Sciences and FALW)(Faculty of Earth and Life Sciences). Vakken:

Naam

Periode

Credits

Code

Advanced Cardiac Diagnostics

Period 1, Period 4

3.0

M_CCARDIA09

Ethical Dimensions of Medical Research on Human Subjects

Period 4

3.0

M_CETHICA09

Extension Practical Training Ac. Jaar (september)

3.0

M_CEXTENS09

Life Cell Imaging

3.0

M_CLIFECE09

6.0

M_CMODEL09

3.0

M_CPROTBI09

3.0

M_CRADPRO09

Ac. Year (September), Period 4

Modelling and Simulation in Medical Natural Sciences Proteomics in Biomedical Research

Period 4

Radiation Protection Course, Level 5B

Master Cardiovascular Research - Compulsory Courses All students of the Cardiovascular Research Master have to attend the compulsory Courses of the programme. If more study places are available, students of other Master's programmes can attend the course, providing that they meet the entry requirements. Vakken:

Naam

Periode

Credits

Code

Biostatistics

Ac. Year (September), Period 2, Period 3

3.0

M_CBIOSTA09

Clinical and Biophysical Aspects of Cardiovascular Diseases and Imaging

Ac. Year (September), Period 1

6.0

M_CCLINBIO09

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Pathophysiology of Heart and Circulation

Ac. Year (September), Period 1

6.0

M_CPATHO09

Remodelling of the Circulatory System

Ac. Year (September), Period 2

6.0

M_CREMODE09

Vascular Function and Metabolic Diseases

Ac. Year (September), Period 2

6.0

M_CVASCFU09

Writing Scientific English

Ac. Year (September), Period 3+4, Period 3+4+5

3.0

M_FWSE09

Master Cardiovascular Research - Practical Training In total, a student has to spend 63 ECTS credit points for two internships: a minor (=>21 ECTS) and a major (=>36 ECTS). Both internships have to be performed at a research laboratory, acknowledged by the examination board of the Cardiovascular Research Master: One internship has to be performed at one of the departments/laboratories of the VU/VUmc and the other one preferentially "outside" the VU. It is not allowed to do both internships outside the VU/VUmc. Thesis The Master's thesis includes the results of the major internship, integrated with and from the perspective of the knowledge acquired in the cursory education. The Master's thesis will get an uniform cover provided and designed by the Master. The Master's thesis will be defended in public. Vakken:

Naam

Periode

Credits

Code

Practical Training 1

Ac. Jaar (september)

23.0

M_CPRACT109

Practical Training 2

Ac. Jaar (september)

40.0

M_CPRACT209

Master Cardiovascular Research - Study of Literature The study of literature will be carried out under supervision, yet highly independent. It is also possible that the student proposes his or her own subject and presents an own question. The study may be focused on a scientific biomedical question, but a more applied or social question is also allowed. The aim of the literature study is that the student will be able to select, evaluate and discuss critically relevant literature. Based on the study, the student has to explain clearly not only the state of the art, but also the limitations and problems. Depending on the context of the study the student has to formulate recommendations and strategies for further research to solve remaining problems. The literature study is written in the format of a review paper. Vakken:

Naam

Periode

Credits

Code

Study of Literature

Ac. Jaar (september)

9.0

M_CLITSTU09

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Course code

M_CCARDIA09 (3120004)

Period

Period 1, Period 4

Credits

3.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. J.G.F. Bronzwaer

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the pathogenesis and treatment of myocardial infarction and the assessment of left ventricular function after infarction The following topics will be addressed: - pathogenesis; - ECG alterations during acute infarction; - treatment and prognosis. The course contains the following practical elements: - ECG; - Echocardiography; - literature study. Type of assessment Written exam. In addition, students will receive their credits only when they have participated in the classes and also have fulfilled all requirements. Course reading Syllabus including relevant articles.

Biostatistics Course code

M_CBIOSTA09 (3120003)

Period

Ac. Year (September), Period 2, Period 3

Credits

3.0

Language of tuition

English

Faculty

VUmc

Coordinator

prof. dr. J.W.R. Twisk

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the practical application of statistical analyses and clinical epidemiology The following topics will be addressed: • confounding and interaction; • analysis of continuous and dichotomous outcome variables; • linear and logistic regression analysis; • multiple regression analysis: prediction and associations models; • analysis of survival data: Kaplan Meier curves and Cox regression analysis; • GLM for repeated measurements. The course contains the practical elements of active analyses of data Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

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(provided by the coordinator) using standard statistical computer software during working groups. Contact: [email protected]

Clinical and Biophysical Aspects of Cardiovascular Diseases and Imaging Course code

M_CCLINBIO09 (3120000)

Period

Ac. Year (September), Period 1

Credits

6.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. J.G.F. Bronzwaer

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the basic principles and clinical aspects of normal cardiac and circulatory function and dysfunction and the development of heart failure. Special attention will be given to the biophysical and clinical aspects of imaging. The following topics will be addressed: • Cardiac excitation and contraction, physics of heart and circulation, hemorheology and fluid dynamics; • Coronary artery disease: ischemic syndromes; • Heart failure: Pathophysiology, diagnosis, treatment and prognosis; • Hypertension and other risk factors of Coronary Artery Disease: Clinical diagnosis, treatment and complications; • Inflammation of the heart: Pericarditis, myocarditis and endocarditis; • Mitral & aortic valve disease; • Aortic and peripheral vascular disease: Clinical spectrum,diagnosis and treatment; •Pulmonary hypertension; • Clinical recognition of supra- and ventricular arrhythmias; • Cardiovascular positron emission tomography, MRI, Ultrasound; • Implants: pacemakers/defibrillators; • Cardiac Resynchronisation Therapy (CRT). This course contains the following practical elements/demonstrations: • Catheterisation room; • MRI; • Echocardiography; Echo- doppler Carotis. Contact: [email protected] Course reading Book: Cardiology, Crawford-Di Marco-Paulus 3rd Ed (recommended) syllabus including relevant articles.

Ethical Dimensions of Medical Research on Human Subjects Course code

M_CETHICA09 (3120009)

Period

Period 4

Credits

3.0

Language of tuition

English

Faculty

VUmc

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Coordinator

dr. A.K. Oderwald

Teaching method(s)

Lecture, Study Group

Course content You will become acquainted with a large scope of subjects related to scientific research involving human beings, medical information and body fluids / tissue samples. You will get an idea of the history of both medical scientific research and evidence based medicine, you will become familiar with the concepts used in research ethics, you will learn how to apply them to concrete ethical questions, and you will learn how to practice the debate of ethical questions in discussions regarding ethical questions in research. Traditionally ethical questions are quite common in You will become acquainted with a large scope of subjects related to scientific research involving human beings, medical information and body fluids / tissue samples. You will get an idea of the history of both medical scientific research and evidence based medicine, you will become familiar with the concepts used in research ethics, you will learn how to apply them to concrete ethical questions, and you will learn how to practice the debate of ethical questions in discussions regarding ethical questions in research. Traditionally ethical questions are quite common in cardiovascular research and treatment. In this short course about ethics and research two main items are discussed. In the first week the subject is ethics and research on human beings. In this week we discuss questions like: • What does the law say about research on human beings and tissues? • How does an medical ethical committee work? • Which ethical principles are important? • What is good information for patients ? In the second week the subject is the tension between treatment and research. In this week we discuss questions like: • Why is it so difficult to change peoples lifestyle? • What ethical problems rise in monitoring lifestyle and risk factors? • What frictions are there in practice between treatment and research? Contact: Apply per email before December 16th, 2011 to the course coordinator: [email protected]. A minimum of five participants is needed. Course reading Reader and internet sources (ca 250 p).

Extension Practical Training Vakcode

M_CEXTENS09 (3120035)

Periode

Ac. Jaar (september)

Credits

3.0

Voertaal

Engels

Faculteit

VUmc

Life Cell Imaging Course code

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Period

Ac. Year (September), Period 4

Credits

3.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. R.J.P. Musters

Teaching method(s)

Lecture, Study Group

Course content Advances in light microscopy, digital image processing, and the development of a variety of powerful fluorescent probes present expanding opportunities for investigating the cardiovascular system. This laboratory and lecture course will provide participants with the theoretical and practical knowledge to utilize novel life cell imaging technologies. Students will learn the principles of light microscopy, as well as use of different types of electronic cameras, laserscanning systems, functional fluophores, delivery techniques, and digital imageprocessing software. Contact: [email protected] Course reading Syllabus including relevant articles.

Modelling and Simulation in Medical Natural Sciences Course code

M_CMODEL09 (3120013)

Credits

6.0

Language of tuition

English

Faculty

VUmc

Coordinator

prof. dr. G.J.M. Stienen

Teaching method(s)

Lecture, Study Group

Course content The course starts with a general overview the various types of models used to describe biomedical processes by parametric and non- parametric models using linear and non- linear (differential) equations. Attention will be paid to spectral analysis, compartment models, algorithms used in image analysis and models to describe molecular structures and their dynamic behaviour. Practical problems discussed during the lectures will concentrate on image analysis of PET and Echo data, modelling using mechanical and electrical analogues, compartment models and physiological processes and a molecular dynamics simulation of a mono atomic liquid. The introductory lectures will be combined and followed by practical courses (working groups and practicals) in which experience will be gained of MatLab, a 4th generation computer language that will be used in all exercises. Finally students will be offered a choice of 1 out of 5 modelling problems to be solved in groups of 2/3 students each, guided by a supervisor. At the end of the course each group will present and discuss their work with all participants and supervisors of the course. Course reading

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Syllabus Book (recommended): MatLab: An Introduction with Applications by Amos Gilat (4th Ed) or Numerical Methods for Engineers and Scientists: an introduction with applications using MatLab. Amos Gilat and Vish Subramaniam (Wiley, 2008).

Pathophysiology of Heart and Circulation Course code

M_CPATHO09 (3120014)

Period

Ac. Year (September), Period 1

Credits

6.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. P. Koolwijk

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the fundamental aspects of normal cardiac function, cardiac dysfunction and the development of heart failure. Basic information will be presented regarding anatomy and physiology of the heart and the circulation in health and disease. The following topics will be addressed: • cardiac function assessment; • signal transduction during cardiac development and hypertrophy; • cardiac diagnosis and therapy; • cardiac arrhythmia; • cardiac necrosis; • cardiac apoptosis. The course contains the following practical elements: • echocardiography; • in vivo assessment of cardiac function in animal models of heart failure. Contact: [email protected] Course reading Book: Cardiology, Crawford-Di Marco-Paulus 3rd Ed.(recommended) syllabus including relevant articles.

Practical Training 1 Vakcode

M_CPRACT109 ()

Periode

Ac. Jaar (september)

Credits

23.0

Voertaal

Engels

Faculteit

VUmc

Practical Training 2 Vakcode

M_CPRACT209 ()

Periode

Ac. Jaar (september)

Credits

40.0

Voertaal

Engels

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Faculteit

VUmc

Proteomics in Biomedical Research Course code

M_CPROTBI09 (3120006)

Period

Period 4

Credits

3.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. J. de Groot-van der Velden

Teaching method(s)

Lecture, Study Group

Course reading Syllabus including relevant articles

Radiation Protection Course, Level 5B Vakcode

M_CRADPRO09 (311164)

Credits

3.0

Voertaal

Engels

Faculteit

VUmc

Coördinator

G.W.M. Visser BSc

Lesmethode(n)

Hoorcollege, Werkgroep

Doel vak Aim of the course "Working with Radioactivity" is preparing researchers, assistants and students for safely working with radioactive substances and/or apparatus emitting ionising radiation. Onderwijsvorm The course encloses one week, divided in theory (~ 40%) and practical work (~60%). For both parts there will be a guide book in Dutch or English available. The experiments will lead to a practical work report to be used as the guidance for futural radiological activities. Participants shall receive a certificate as proof of their participation at the course, if they are judged to work safely with radioactivity. The with this certificate related allowance to work with radioactivity is limited to the laboratories of the Vrije Universiteit / VUmc. Toetsvorm Written exam, twice a year. Only students who pass the Dutch exam and thus obtain the governmental diploma "Stralingshygiëne, deskundigheidsniveau 5B" get 3 ECTS. The diploma gives allowance to work with radioactivity in the Netherlands, and most often even in Europe and America. Doelgroep The course given in the Radionuclide Centre is for students who need the course for working with radioactivity during their study at the Vrije Universiteit / VUmc, and for students who are strongly interested to work with radioactivity in future. Vrije Universiteit Amsterdam - VUmc - M Cardiovascular Research - 2011-2012

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Overige informatie For each course the maximal number of participants is 12. During the year 4 courses (twice in Dutch, twice in English) are given. During the year the possibility of 3 extra courses exists provided the number of participants is at least 8. See for more information: http://www.rnc.vu.nl M.C. Stolker-Bouknecht is the administrator of the RNC-course, Tel: 0204449101, [email protected]. N.B. People who do want to do the course but do not understand Dutch, are before application requested to contact: G.W.M. Visser, coordinator of the course, Tel: 020-4449710, [email protected]

Remodelling of the Circulatory System Course code

M_CREMODE09 (3120001)

Period

Ac. Year (September), Period 2

Credits

6.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. J.W.M. Niessen

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the pathophysiological mechanisms of vascular remodelling in pulmonary disease and ischemia. The following topics will be addressed: • pathophysiology of angiogenesis; • vascular and cardiac effects of pulmonary hypertension; • the role of fat tissue in vascular regulation; • the effect of mechanical ventilation on the cardiovascular system. The course contains the following practical elements: • 3D-life cell imaging of vascular cells; • isolation and culture of vascular smooth muscle cells; • protein analysis & proteomics in vascular disease/stress; • pressure measurements of blood vessels ex-vivo; preparation of animal and human tissue. Contact: [email protected] Course reading Book: to be announced; syllabus including relevant articles.

Study of Literature Vakcode

M_CLITSTU09 (3120036)

Periode

Ac. Jaar (september)

Credits

9.0

Voertaal

Engels

Faculteit

VUmc

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Vascular Function and Metabolic Diseases Course code

M_CVASCFU09 (3120002)

Period

Ac. Year (September), Period 2

Credits

6.0

Language of tuition

English

Faculty

VUmc

Coordinator

dr. H.J. Blom

Teaching method(s)

Lecture, Study Group

Course content This course focuses on the fundamental role of inflammation, diabetes and hyperhomocysteinemia in vascular disease. Pathophysiology, new diagnostics and development of new therapies will be presented. The following topics will be addressed: • diabetes and vascular disease; • diabetes and cardiac disease; • hyperhomocysteinemia and vascular disease; • inflammation and vascular disease: the role of sepsis; • diagnostics of vascular complications; • endovascular surgery as a new therapy in vascular disease. The course contains the following practical elements: • in vivo assessment of vascular function in humans; • flow- cytometry of inflammatory cells / mediators; • isolation and culture of endothelial cells; • protein analysis & proteomics in vascular disease. Contact: [email protected] Course reading Book: to be announced; syllabus including relevant articles.

Writing Scientific English Course code

M_FWSE09 (3120015)

Period

Ac. Year (September), Period 3+4, Period 3+4+5

Credits

3.0

Language of tuition

English

Faculty

VUmc

Coordinator

M.M. van Duist

Course content Focus will be on the following subjects: • writing texts; • writing sentences; • writing a curriculum vitae; • writing a letter of application; • writing emails

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Form of tuition 24 contact hours (24 active participation). The course is focussed on self-tuition in 8 sessions of 3 hours each. The plenary sessions concentrate on the process of writing and the product is part of writing. Homework is part of the course. Type of assessment No examination will be held. However, students of the Master Course in Oncology will receive their credits only when they have participated in at least 80% of the lessons and, also, when they have done all their homework. Students will receive a pass (not a mark) when they have finished the course. Course reading The course material consists of a syllabus containing all relevant information. Students also work with their own material: they write reports, letters, papers, emails, which are reviewed by, and together with, the teacher. Course Reader: € 15,-. Target group This course is compulsory for students of the Master Course in Oncology and in Cardiovascular Research. Remarks After completing the course, the student will be able to employ a series of expressions and techniques for writing clear and effective English. Being able to employ a wide range of linguistic expressions covering the most frequent textual functions in written English. Have a better command of the grammatical structures which are frequent in English academic writing and which traditionally cause problems for the non native English writer.

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