Biological Chemistry

Vol. 269, The Journal of No. 26 July 1,1994 Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, ...
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Vol. 269,

The Journal of

No. 26

July 1,1994

Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc. 428 East Preston St., Baltimore, MD 21202 U.S.A.

CONTENTS’ MINIREVIEW

17411 Bactericidal/permeability-increasingproteinand lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. Craig G. Wilde, Jeffrey J. Seilhamer, Michael McGrogan, Nina Ashton, James L. Snable, John C . Lane, Steven R. Leong, Michael B. Thornton, Kathleen L. Miller, Randy W. Scott, and Marian N . Marra

17359 Signal transduction and gene regulation: The nuclear response to CAMP. Enzo Lalli and Paolo SassoneCorsi COMMUNICATIONS 17363 Physical association between Src homology 3 elements and the protein product of the c-cbl protooncogene. Octavio M . Riuero-Lezcano, Jeanne H. Sameshima, AntonioMarcilla, and Keith C. Robbins

17417 Expression of GTPase-deficient Gale inhibits Swiss 3T3 cell growth. Nan-Xin Qian, Marijane Russell,Anne Mette Buhl, and Gary L. Johnson

17367 The organization of the gene for the functionally dominant a-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor subunit GluR-B. Martin Kohler, Hans-Christian Kornau, and Peter H. Seeburg

17424 Structural characterization andchromosomal location of the gene encoding human platelet glycoprotein Ib8. Mayumi Yagi, Susanne Edelhoff, Christine M. Disteche, and Gerald J.Roth

17371 A polymorphism (G + A transition)inthe -78 position of theapolipoprotein A-I promoterincreases transcription efficiency. Elvira Angotti, Euelina Mele, Francesco Costanzo, and Enrico V. Avvedimento

17428 A germ line-specific sequence element in an intron in Tetrahymena thermophila. Taisto Y. K. Heinonen and Ronald E. Pearlman 17434 Cloning of the NCX2 isoform of the plasma membrane Na+-Ca2+exchanger. Zhaoping Li, Satoshi Matsuoka, Larry V. Hryshko, Debora A. Nicoll,Malcolm M. Bersohn, Edmund P. Burke, Richard P. Lifton, and Kenneth D. Philipson

17375 Evidence for similar structural organizationof the multienzyme aminoacyl-tRNA synthetase complex in vivo and in vitro. Valery V . Filonenko and Murray P. Deutscher

17440 Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1or 2. A n Zhou and Richard E. Mains

17379 Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps. Bill P. Crider, Xiao-Song Xie, and Dennis K. Stone 17382 ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26 S proteasome. Fuminori Tokunaga, Tamami Goto, TakehikoKoide,YasukoMurakami,Shin-ichiHayashi,Tomohiro Tamura, Keiji Tanaka, and Akira Ichihara

17448 Cold adaptation of proteins. Purification, characterization, andsequence of the heat-labilesubtilisin from the antarctic psychrophile Bacillus TA41. Stephane Dauail, Georges Feller, EmmnnuelNarinx, and Charles Gerday

17386 Evidence that production and release of amyloid 8protein involves the endocytic pathway. Edward H. Koo and Sharon L. Squazzo

17454 Expression in Escherichia coli of the two subunits of the isozyme form of wheat germ protein synthesis initiation factor4F. Purification of the subunits and formation of an enzymatically active complex. A n n van Heerden and Karen S. Browning

17390 Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Craig C. Correll, Linda Ng, and Peter A. Edwards

17458 The thylakoid-targeting domain of the chloroplast Rieske iron-sulfur protein is located in the N-terminal hydrophobic region of the mature protein. Francisco Maduerio, Stephen A. Bradshaw, and John C. Gray

17394 Ribonuclease A can be transformed into a dimeric ribonuclease with antitumor activity. Albert0 Di Donato, Valeria Cafaro, and Giuseppe D’Alessio 17397 A heteroduplex template circumvents the energetic requirement for ATP during activated transcription by RNA polymerase 11. Dean Tantinand Michael Carey ARTICLES

17464 The 86-kDa subunit of autoantigen Ku is a somatostatinreceptorregulatingprotein phosphatase-2A activity. Muriel Le Romancer, Florence ReylDesmars, Yacine Cherifi, Catherine Pigeon, Serge Bottari, Olivier Meyer, and Miguel J. M. Lewin 17469 SV40large-T oncogene inhibitstranscription of perlecan-related proteoglycans but stimulates hyaluronan synthesis in a temperature-sensitive renal-tubule principalcell line.Remi Piedagnel, DominiquePrie,RolandCassingena,Pierre M . Ronco,and Brigitte Lelongt

17401 An amino acid sequence sharedby the herpes simplex virus 1 a regulatory proteins 0, 4, 22, and 27 predicts the nucleotidylylation of the UL21, UL31, U ~ 4 7and , U ~ 4 gene 9 products. J o h n A. Blaho, Clayton Mitchell, and Bernard Roizman

* The CONTENTS arrangedby Subject Categories will be found immediatelyfollowing these CONTENTS. Full Instructions to Authors will be found in (1994) J . Biol. Chem. 269, 777-785, and reprints may be obtained from the editorialoffice.

...

111

v 17477 Role of Leu-j388 in thehydrophobic acceptor pocket for Val-86 during hemoglobin S polymerization. Kazuhiko Adachi, Patrick Konitzer, Christopher G. Paulraj, and Saul Surrey 17481 Optimal sequence and structure of iron-responsive

elements. Selection of RNA stem-loops with high affinity for iron regulatory factor. Beric R. Henderson, Eric Menotti, Claude Bonnard, and Lukas C. Kuhn 17490 The role of spontaneous cap domain mutations in

haloalkane dehalogenase specificity and evolution. Frens Pries, Arjan J. van den Wijngaard, Rolf Bos, Marjan Pentenga, and Dick B. Janssen 17495 Activation of novel protein kinases C8 and Ct upon

mitogenic stimulation of quiescent rat 3Y1 fibroblasts. Shigeo Ohno, Keiko Mizuno, Yasushi Adachi, Akiko Hata, Yoshikn Akita, Kazunori Akimoto, Shin-ichiOsada, Syu-ichi Hirai, and Koichi Suzuki 17502 Identification and characterization

of a putative bile acid-responsive element in cholesterol 7a-hyJohn Y. L. Chiang and Diane droxylase gene promoter. Stroup

17508 Protein kinase C activity is required for lipid oxi-

dation of low density lipoprotein by activated human monocytes. Qing Li and Martha K. Cathcart 17516 Insulin-stimulated GLUT4 glucose transporter re-

cycling. A problem in membrane protein subcellular trafficking through multiple pools. Geoffrey D. HOEman, Leila Lo Leggio, and Samuel W. Cushman 17525 Flavin-containing monooxygenase (FM0)-depend-

ent metabolism of methionine andevidencefor FM03 being the major FMO involved in methionine sulfoxidationinrabbitliverandkidney microsomes. Renee J . Duescher, Michael P. Lawton, Richard M. Philpot, and AdnanA. Elfarra 17531 Crystal structure of RNase T1 complexed with the

product nucleotide 3'-GMP. Structural evidence for direct interactionof histidine 40 and glutamicacid 58 with the 2'-hydroxyl group of the ribose. Keigo Gohda, Ken-ichi Oh, Ken-ichi Tomita, and Toshio Hakoshimn of a novelEmbdenMeyerhof pathway that involves ADPdependent kinases during sugar fermentation by Pyrococcus furiosus. Serve W. M . Kengen, Frank A. M. deBok,Nico-Dirkuan Loo, Cor Dijkema, Alfom J. M. Stams, and Willem M.de Vos

17537 Evidence for the operation

17542 Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-8 gene expression.Rongtuan Lin, Amir Mustafa, Hannah Nguyen, Dirk Gewert, andJohn Hiscott 17550 3',3",5',5"-Tetraiodophenolsulfonephthalein is a selective inhibitor of Cas+-pumping ATPase in intracellular Ca2+store. Asami Seino, Ken-lchi Furukawa, Tsutomu Miura, Toshiko Yaginuma, Kazutaka Momose, and Yasushi Ohizumi 17556 Cloning andsequencing

of ratkidneyL-arginine:glycine amidinotransferase.Studies on the mechanism of regulation by growth hormone and creatine. Pamela Guthmiller,John F. Van Pilsum, James R. Boen, and Denise M. McGuire

7561 Rapid filtration studies of the effect of cytosolic ea2+

on inositol 1,4,5-trisphosphate-induced46Ca2+release from cerebellarmicrosomes. Laurent Combettes, ZalikaHannaert-Merah,Jean-Frangois Coquil, Caroline Rousseau, Michel Claret, Stephane Swillens, and Philippe Champeil 7572 Expression on outer membranes of mannose resi-

dues, whichare involved in osteoclast formation via cellular fusion events. Toshiaki Kurachi, Zkuo Morita, ToshikazuOki,TomokazuUeki,KoujiSakaguchi,Shoji Enomoto, and Sei-itsu Murota 17577 Active vacuolar H+ATPase is required for both en-

docytic and exocytic processes during viral infection of BHK-21 cells. Harri Palokangas, Kaleruo Metsikko, and Kalervo Vabniinen 17586 a t p k l , a novel ribosomal protein kinase gene from

Arabidopsis. I. Isolation, characterization,and expression. Shao-Hui Zhang, Michael A. Lawton, Tony Hunter, and Christopher J. Lamb 17593 a t p k l , a novel ribosomal protein kinase gene from Arabidopsis. 11. Functional and biochemical analysis of the encoded protein. Shao-Hui Zhang, Martin A. Broome, MichaelA. Lawton, Tony Hunter, and Christopher J. Lamb 17600 Nupl07 is a novel nuclear pore complex protein that containsa leucine zipper. Aurelian Radu, Gunter Blobel, and Richard W . Wozniak 17606 Bacterial lipopolysaccharide has structural similar-

ity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. Cecil K. Joseph, Samuel D.Wright,William G. Bornmann,John T. Randolph, Erukulla Ravi Kumar, Robert Bittman, Jun Liu,and Richard N . Kolesnick 17611 Purification and enzymatic properties of peptide:N-

glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrenceof posttranslational remodification of proteins by N-deglycosylation. Tadashi Suzuki, Akira Seko, Ken Kitajima, Y a s m Inoue, and Sadako Inoue 17619 Prostaglandin F,, enhances tyrosine phosphoryla-

tion and DNA synthesis through phospholipase Ccoupled receptor via Ca2+-dependent intracellular pathway in NIH-3T3 cells. Tsuyoshi Watanabe, AkihideNakao,DanielEmerling,YoshiakiHashimoto,Kazuhisa Tsukamoto, Yukio Horie, Makoto Kinoshita, and Kiyoshi Kurokawa 17626 Purification, cloning, and expression of a murine

KBmotif in vitroidenphosphoprotein that binds the tifies itas the homolog of the humanheterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation process. Jerzy Ostrowski, Isabelle VanSeuningen,Rony Seger, Charles T. Rauch, Paul R. Sleuth, Brad A. McMutlen, and Karol Bomsztyk 17635 Novel gene expression system for plant cells based

on induction of a-amylase promoter by carbohydrate starvation.Ming-Tsair Chan, Yu-ChanChao, and Su-May Yu

The Journal of Biological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc., 428 East Preston Street, Baltimore, MD 21202, U S A . Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/Postdoctora1 Fellows: United States, $140; Foreign, $330. CD-ROM (available only with printed subscription): United States,$60; Foreign, $65. (Note: Maryland, Pennsylvania, and Canada add applicable taxes, unless a tax-exempt certificate number is shown.) The GST number for Canadian subscribers is 130369721. Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices. Printed in the U.S.A. POSTMASTER:Send address changes to THE JOURNALOF BIOLOGICAL CHEMISTRY a t 428 East Preston Street, Baltimore, M D 21202, U.S.A.

vi

17642 Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Racbinding and GTPase-activating residues by mutational analysis. Sohail Ahmed, Joel Lee, Lung-Ping Wen, Zhuoshen Zhao, Jerome Ho, Anthony Best,Robert Kozma, and Louis Lim 17649 Theadultratbrainsubunit modifies activation and inactivation gatingof multiple sodium channel a subunits. D. Earl Patton, Lori L.Isom,William A. Catterall, and Alan L. Goldin 17656 Annexin VI-binding proteins in brain. Interaction of annexin VI with a membrane skeletal protein, calspectin (brain spectrin or fodrin). Tatsuo Watanabe, Makoto Inui, Bo- Ying Chen, Masahide &a, and Kenji Sobue 17663 DNA-binding domain and recognition sequence of the yeastBAS1 protein, a divergent member of the Myb family of transcription factors.Per Zuar [email protected], Anne Bostad, Eli Ording, Astrid Hilde Myrset, and Odd Stokke Gabrielsen

of 17670 Role of plastoquinol oxidoreduction in regulation photochemical reaction center IIDl protein turnover invivo. Hagit Zer, Ondrej Prasil,and Itzhak Ohad 17677 Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle’s loop and collecting ducts of rat kidney. Susumu Adachi, Shinichi Uchida, Hiroshi Ito, Mimi Hata, Michiaki Hiroe, Fumiaki Marumo, and Sei Sasaki 17684 KB binding activity in a murine macrophage-like KBbinding cell line. Sequence-specificdifferences in and transcriptional activation functions. Yoshihiro Ohmori, Julie Tebo, Sergei Nedospasov,andThomas A . Hamilton 17691 Poly(ADP-ribose) molecules formedduring DNA repair in vivo. Maria Malangu and Felix R. Althaus

of mRNA 17697 Characterization and partial purification P-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. Joseph A . Bokar, Mary Eileen RathShambaugh, Rachael Ludwiczak,PremaNarayan, and Fritz Rottman

17705 Highyieldexpression of the Neurospora cra8sa plasma membrane H+-ATPase inSaccharomyces cerevisiae. Sanjoy K . Mahanty, U. Subrahmanyeswara Rao, Robert A. Nicholas, and Gene A. Scarborough 17713 Molecular cloning, primary structure, and characterization of two membersof the mammmalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. Gerard0 Gamba, Akihiko Miyanoshita,Michael Lombardi, Jonathan Lytton, Wen-SenLee, Matthias A . Hediger, and Steven C. Hebert 17723 The N-terminal a-helix of fragment B of diphtheria toxin promotes translocation of fragment A into the cytoplasm of eukaryotic cells. Inger Helene Madshus 17730 Identification and characterization of a promiscuous chemokine-bindingprotein ina human erythroleukemic cell line. Richard Horuk, Wang Zi-xuan, Stephen C. Peiper, and Joseph Hesselgesser 17734 Stable expressionof human platelet-derived growth factor B chain by bovine aortic endothelial cells. Matrix association and selective proteolytic cleavage by thrombin. Abigail A. Soyombo and Paul E. DiCorleto 17741 Mutations associated with a locus for familial Alzheimer’s disease result in alternativeprocessing of amyloid &protein precursor. Christian Haass, Albert Y. Hung, Dennis J . Selkoe, and David B. Teplow 17749 Raf- 1interacts with Fyn and Srca non-phosphoin tyrosine-dependent manner.Vaughn Cleghon and Deborah K . Morrison

ADDITIONSAND

CORRECTIONS

17756 Cone arrestin identified by targeting expression of a functional family. Vol. 269 (1994) 4613-4619. Cheryl M. Craft, Donald H.Whitmore, and Allan F. Wiechmann 17756 Generality of the shared active site among yeast family site-specific recombinases. The R site-specific recombinase follows the Flp paradigm. Vol. 269 (1994) 12789-12796. Sang Hwa Yang and Makkuni Jayaram

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The Journal of Biological Chemistry

Vol. 269, No. 26

July 1, 1994

CONTENTS Arranged by Subject Categories MINIREVIEW

17516 Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools. GeoffreyD. Holman, Leila Lo Leggio, and Samuel W. Cushman

17359 Signal transduction and gene regulation: The nuclear response toCAMP.Enzo Lalli and Paolo SassoneCorsi

17537 Evidence fortheoperation of a novel EmbdenMeyerhof pathway that involves ADPdependent kinases during sugar fermentation by Pyrococcm furioeue. Serve W. M. Kengen, Frank A. M. de Bok,Nico-Dirkvan L o o , Cor Dijkema, Alfons J. M. Stams, and Willem M. de Vos

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS of peptide:N17611 Purification and enzymatic properties glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of posttranslational remodification of proteins by N-deglycosylation. Tadashi Suzuki, Akira Seko, Ken Kitajima, Yasuo Inoue, and Sadako Inoue

17572 Expression on outer membranes of mannose residues, which are involved in osteoclast formation via cellular fusion events. Toshiaki Kurachi, Ikuo Morita, Toshikazu Oki, TomokazuUeki,Kouji Sakaguchi, Shoji Enomoto, and Sei-itsu Murota

CELL BIOLOGY ANDMETABOLISM 017363 Physical association between Src homology 3 elements and the protein product of the c-cbl protooncogene. Octavio M. Rivero-Lezcano, Jeanne H. Sameshima, Antonio Marcilla, and Keith C. Robbins

17577 Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells. Harri Paloknngas, Kalervo Metsikko, and Kalervo Vliiinanen

17386 Evidence that production and release of amyloid j3protein involves the endocytic pathway. Edward H. Koo and Sharon L. Squazzo

17593 atpkl, a novel ribosomal protein kinase gene from Arabidopeis. 11. Functional and biochemical analysis of the encoded protein. Shao-Hui Zhang, Martin A. Broome, Michael A. Lawton, Tony Hunter,and Christopher J. Lamb

a17390 Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Craig C. Correll, Linda Ng, and Peter A. Edwards

17600 Nupl07 is a novel nuclear pore complex protein that contains a leucine zipper. Aurelian Radu, Giinter Blobel. and Richard W. Wozniak

17411 Bactericidal/permeability-increasing proteinand lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. Craig G. WiMe, Jeffrey J. Seilhamer, Michael McGrogan, Nina Ashton, James L. Snable, John C. L a n e , Steven R. Leong, Michael B. Thornton, Kathleen L. Miller, Randy W. Scott, and Marian N. Marra

17606 Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. Cecil K. Joseph, Samuel D. Wright,William G. Bornmann,John T. Randolph, Erukulla Ravi Kumar, Robert Bittman, Jun Liu, and Richard N. Kolesnick 17619 Prostaglandin F,, enhances tyrosine phosphorylation and DNA synthesis through phospholipase Ccoupled receptor via Ca'+-dependent intracellular pathway in NIH-3T3 cells. Tsuyoshi Watanabe, Akihide Nakao, Daniel Emerling, Yoshiaki Hashimoto, Kazuhisa Tsukamoto, Yukio Horie, Makoto Kinoshita, and Kiyoshi Kurokawa

17417 Expression of GTPase-deficient Gale inhibits Swiss 3T3 cell growth. Nan-Xin Qian, Marijane Russell, Anne Mette Buhl, and Gary L. Johnson 17440 Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2. A n Zhou and Richard E. Mains

17626 Purification, cloning, and expression of a murine phosphoprotein that binds the KB motif in vitro identifies itas the homolog of the human heterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation process. Jerzy Ostrowski, Isabelle Van Seuningen,Rony Seger, Charles T.Rauch, Paul R. Sleuth, Brad A. McMullen, and Karol Bomsztyk

17464 The 86-kDa subunit of autoantigen Ku is a somatostatinreceptorregulatingprotein phosphatase-2A activity. Muriel Le Romancer, Florence ReylDesmars, Yacine Cherifi, Catherine Pigeon, Serge Bottari, Olivier Meyer, and Miguel J. M. Lewin 17469 SV40large-T oncogene inhibitstranscription of perlecan-related proteoglycans but stimulates hyaluronan synthesis in a temperature-sensitive renal-tubule principalcell line.Remi Pikdagnel, Dominique Prie, Roland Cassingena, Pierre M. Ronco, and Brigitte Lelongt

17656 Annexin VI-binding proteins in brain. Interaction of annexin VI with a membrane skeletal protein, calspectin (brain spectrin or fodrin). Tatsw Watand e , Makoto Inui, Bo- Ying Chen, Masahide Iga, and Kenji Sobue

17495 Activation of novel protein kinases C6 and CCupon mitogenic stimulation of quiescent rat 3 Y 1 fibroblasts. Shigeo Ohno, Keiko Mizuno, Yasushi Adachi, Akiko Hata, Yoshiko Akita, Kazunori Akimoto, Shin-ichi Osada, Syu-ichi Hirai, and Koichi Suzuki

17677 Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. Susumu Adachi, Shinichi Uchida, Hiroshi Ito, Mimi Hata, Michiaki Hiroe, Fumiaki Marumo, and Sei Sasaki

17508 Protein kinase C activity is required for lipid oxidation of low density lipoprotein by activated human monocytes. Qing Li and Martha K. Cathcart

17691 Poly(ADP-ribose) molecules formed during DNA repair in vivo. Maria Malanga and Felix R. Althaus

Indicates a Communication vii

...

Vlll

17713 Molecular cloning, primary structure, and charac-

terization of two membersof the mammmalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. Gerard0 Gamba, Akihiko Miyanoshita, Michael Lombardi, Jonathan Lytton, Wen-Sen Lee, Matthias A. Hediger, and Steven C. Hebert 17723 The N-terminal a-helix of fragment B of diphtheria

toxin promotes translocation of fragment A into the cytoplasm of eukaryotic cells. Inger Helene Madshus 134 Stable expression of human platelet-derived growth

factor B chain by bovine aortic endothelial cells. Matrix association and selective proteolytic cleavage by thrombin. Abigail A. SoyomboandPaulE. DiCorleto 741 Mutations associated with a locus for familial Alz-

heimer’s disease result in alternativeprocessing of amyloid &protein precursor. Christian Haass, Albert Y. Hung, Dennis J. Selkoe,and David B. Teplow 17749 Raf-1 interacts with Fyn and Srca non-phosphoin

tyrosine-dependent manner.Vaughn Cleghon and Deborah K. Morrison

ENZYMOLOGY

17649 The adult rat brain & subunit modifies activation

and inactivation gatingof multiple sodium channel Lori L.Isom,WilliamA. Catterall, and Alan L. Goldin

a subunits. D.EarlPatton,

17670 Role of plastoquinol oxidoreduction in regulationof

photochemical reaction center IIDl protein turnover invivo. Hagit Zer, Ondrej Prasil, and Itzhak Ohad 17705 Highyieldexpression

of the Neurospora crassa plasma membrane H+-ATPase inSaccharomyces cerevisiae. SanjoyK.Mahanty, U. Subrahmanyeswara Rao, Robert A . Nicholas, and Gene A. Scarborough

NUCLEIC ACIDS, PROTEINSYNTHESIS, MOLECULAR GENETICS

AND

017367 The organization of the gene for the

functionally dominant a-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor subunit GluR-B. Martin Kohler, Hans-Christian Kornau, and Peter H. Seeburg

017371 A polymorphism (G

4 A transition)inthe -78 position of the apolipoprotein A-I promoterincreases transcriptionefficiency. Elvira Angotti, Euelina Mele, Francesco Costanzo, and EnricoV. Avvedimento

017375 Evidence for similar structural organizationof the

017382 ATP- and antizyme-dependent endoproteolysis of

ornithine decarboxylase to oligopeptides by the 26 S proteasome. Fuminori Tokunaga, Tamami Goto, TakehikoKoide,YasukoMurakami,Shin-ichiHayashi,Tomohiro Tamura, Keiji Tanaka, and Akira Ichihara 17525 Flavin-containing monooxygenase (FM0)-depend-

ent metabolism of methionine and evidence for FM03 being the major FMO involved in methionine sulfoxidation inrabbitliverandkidney microsomes. Renee J. Duescher, Michael P. Lawton, Richard M. Philpot, and Adnan A. Elfarra 17550 3’,3”,6’,5”-Tetraiodophenolsulfonephthaleinis a

selective inhibitor of Ca2+-pumping ATPase in intracellular Ca2+store. Asami Seino, Ken-Ichi Furukawa, Tsutomu Miura, Toshiko Yaginuma, Kazutaka Momose, and Yasushi Ohizumi 17642 Breakpoint cluster region gene product-related do-

main of n-chimaerin. Discrimination betweenRacbinding and GTPase-activating residues by mutational analysis. Sohail Ahmed, Joel Lee, Long-Ping Wen, Zhuoshen Zhao, Jerome Ho, Anthony Best,Robert Kozma, and Louis Lim

MEMBRANES AND BIOENERGETICS flow through the H+ channel of vacuolar proton pumps. Bill P.Crider, Xiao-Song Xie, and Dennis K. Stone

multienzyme aminoacyl-tRNA synthetase complex in vivo and in vitro. Valery V. Filonenko and Murray P. Deutscher 17397 A heteroduplex template circumvents the energetic

requirement for ATP during activated transcription by RNA polymerase 11. Dean Tantinand Michael Carey 17424 Structural characterization andchromosomal loca-

tion of the gene encoding human platelet glycoproMayumi Yagi, Susanne Edelhoff, Christine M. tein Disteche, and Gerald J. Roth

Ibs.

17428 A germ line-specific sequence element in an intron

in Tetrahymena thermophila. Taisto Y. K. Heinonen E. Pearlman

and Ronald

17454 Expression in Escherichia coli of the two subunits

of the isozyme form of wheat germ protein synthesis initiation factor4F. Purification of the subunits and formation of an enzymatically active complex. A n n van Heerden and KarenS. Browning 17458 The thylakoid-targeting domain of the chloroplast

Rieske iron-sulfur protein is located in the N-terminal hydrophobic region of the mature protein. Francisco Maduerio, Stephen A. Bradshaw, and J o h n C. Gray

*17379 Bafilomycin inhibits proton

17434 Cloning of the NCX2 isoform of the plasma mem-

17481 Optimal sequence and structure of iron-responsive

elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.Beric R. Henderson, Eric Menotti, Claude Bonnard, and Lukas C. Kuhn

brane Na+-Ca2+exchanger. Zhaoping Li, Satoshi Matsuoka, Larry V. Hryshko, Debora A. Nicoll,Malcolm M .

Bersohn, Edmund P. Burke, Richard P. Lifton, neth D. Philipson

and

Ken-

17502 Identification and characterization

of a putative bile acid-responsive element in cholesterol 7a-hydroxylase genepromoter. J o h n Y. L. Chiang and Diane Stroup

17561 Rapid filtration studies of the effectof cytosolic Ca2+

on inositol 1,4,6-trisphosphate-induced4aCa2+release from cerebellarmicrosomes. Laurent Combettes, ZalikaHannaert-Merah,Jean-FranGois Coquil, Caroline Rousseau, Michel Claret, Stephane Swillens, and Philippe Champed 17586 atpkl, a novel ribosomal protein kinase gene from

Arabidopsis. I. Isolation,characterization,and expression. Shao-Hui Zhang, Michael A. Lawton, Tony Hunter, and Christopher J. Lamb

Indicates a Communication

17542 Mutational analysis of interferon (IFN) regulatory

factors 1 and 2. Effects on the induction of IFN-j3 gene expression. Rongtuan Lin, Amir Mustafa, Hannah Nguyen, Dirk Gewert, and John Hiscott 17556 Cloning and sequencing of ratkidneyL-argi-

nine:glycine amidinotransferase.Studies on the mechanism of regulation by growth hormone and creatine. Pamela Guthmiller, John F. Van Pilsum, James R. Boen, and Denise M. McGuire

ix 17635 Novel gene expression system for plant cells based on induction of a-amylase promoter by carbohydrate starvation.Ming-Tsair Chan, Yu-ChanChao, and Su-May Yu

17401 An amino acid sequence shared by the herpes simplex virus 1 a regulatory proteins 0, 4, 22, and 27 predicts the nucleotidylylation of the UL21, UL31, UL47, and UL49 gene products. John A.B l a h , Clayton Mitchell, and Bernard Roizman

17663 DNA-binding domain and recognition sequence of the yeast BAS1 protein,a divergent member of the Myb family of transcription factors.Per Zvar Hflvring, Anne Bostad, Eli Ording, Astrid Hilde Myrset, and Odd Stokke Gabrielsen

17448 Cold adaptation of proteins. Purification, characterization, andsequence of the heat-labile subtilisin from the antarctic psychrophile Bacillus TA41. Stephane Dauail, Georges Feller, EmmanwlNarinx, and Charles Gerday

17684 KB binding activity in a murine macrophage-like cell line. Sequence-specific differences inKBbinding and transcriptional activation functions. Yoshihiro Ohmori, Julie Tebo,Sergei Nedospasou, and Thomas A. Hamilton 17697 Characterization and partial purificationof mRNA W-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. Joseph A. Bokar, Mary Eileen RathShambaugh, Rachael Ludwiczak, PremaNarayan, and Fritz Rottman 17756 Cone arrestin identified by targeting expression of a functional family. Vol. 269 (1994) 4613-4619. Cheryl M. Craft, Donald H.Whitmore, and Allan F. Wiechmann PROTEIN CHEMISTRY

AND STRUCTURE

-17394 Ribonuclease A can be transformed into a dimeric ribonuclease with antitumor activity. Albert0 Di Donato, Valeria Cafaro, and Giuseppe D'Alessio

Indicates a Communication

17477 Role of Leu-888 in thehydrophobic acceptor pocket for Val-86 during hemoglobin S polymerization. Kazuhiko Adachi, Patrick Konitzer, Christopher G. Paulraj, and Saul Surrey 17490 The role of spontaneous cap domain mutations in haloalkane dehalogenase specificity and evolution. Frens Pries, Arjan J. van den Wijnganrd, Rolf Bos, Marian Pentenga, and Dick B. Jamsen 17531 Crystal structure of RNase T 1 complexed with the product nucleotide 3'-GMP. Structural evidence for direct interaction of histidine 40 andglutamic acid 58 with the 2'-hydroxyl group of the ribose. Keigo Gohda, Ken-ichi O h , Ken-ichi Tomita, and Toshio Hakoshima 17730 Identification and characterization of a promiscuous chemokine-bindingprotein ina human erythroleukemic cell line. Richard Horuk, Wang Zi-xunn, Stephen C. Peiper, and Joseph Hesselgesser 17756 Generality of the shared active site among yeast family site-specific recombinases. The R site-specific recombinase follows the Flp paradigm. Vol. 269 (1994) 12789-12796. Sang Hwa Yang and Makkuni Jayaram

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