Biological, Biomedical and Environmental Sciences

BSc (Hons) Bi Med Science: Biological, Biomedical and Environmental Sciences Provided by the School of Biological, Biomedical and Environmental Scien...
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BSc (Hons) Bi Med Science:

Biological, Biomedical and Environmental Sciences Provided by the School of Biological, Biomedical and Environmental Sciences, University of Hull 2015 intake Study themes: Cancer biology Cardiology Molecular aspects of disease Genetics Fertility and developmental biology Medical microbiology Information about the School: The School of Biological, Biomedical and Environmental Sciences at Hull offers a wide range of degrees including biomedical science, biology, biology with molecular bioscience and human biology as well as zoology, aquatic zoology and marine and freshwater biology. The biomedical science degree in particular has proved extremely popular and has met a need within the health service for training scientists for work within a hospital environment. The degrees offered in the School reflect the research interests of the staff, which are broadly divided into marine and freshwater biology, ecology and evolution, and molecular and cellular biosciences. Of particular interest to potential intercalating students is the molecular and cellular biosciences research. This encompasses a variety of topics including the processes involved in heart failure, cancer immunology, cancer diagnosis, cancer chemotherapy, and medical microbiology. The focus on high quality research in the School is delivering powerful insights into fundamental biological questions, as well as translational research with clear implications for medicine. Key to these advances is our ability to study biological processes at the molecular and cellular levels, and thus provide the mechanistic understanding to underpin the design of new diagnostic tools and treatments. Over the past few years there has been considerable investment into upgrading the facilities within the School. This includes the refurbishment of teaching and research laboratories and the opening in 2012 of the new Biomedical Science building, the Allam building. This investment in infrastructure has been coupled with recruitment to a number of new appointments thus strengthening the Schools research profile. The intercalated degree with HYMS will allow students to do an intensive research project in the laboratory, providing firsthand insight into the problem solving and organisational skills

required in doing research. An indication of the research topics in the department can be found by looking at the research interests of the staff below. In addition, lecture courses offer the students the opportunity to broaden and strengthen their biological knowledge and understanding, providing a powerful complement to their medical training. Research project supervisors relevant to medicine and indicative project themes: Cancer biology Dr Lynn Cawkwell Prof John Greenman Dr Steven Maher Dr Isabel Pires Dr Elena Rosca Dr Justin Sturge Dr Jennifer Waby cycle

Identification of novel cancer biomarkers by proteomics Tumour biology (genetics, cytogenetics, immunology) Gastrointestinal cancer biology and anti-cancer therapeutics Novel regulators of the aspect of the tumour microenviroment Rational design approaches for targeting cancer and immune cells Prostate cancer The Sp1 transcription factors and their role in cancer and the cell

Cardiology Mr Ian Chetter Dr Chris Cawthorne Dr Charlotte Dyer Dr Sandra Jones Dr Anne-Marie Seymour Dr Shang-Zhong Xu

Assessment of vascular surgery procedures Validation of molecular imaging agents Lab on a chip technology and diagnosis of disease Cardiology and aging Cardiac hypertrophy and cellular remodeling of the heart Identification of ion channel genes in the cardiovascular system

Molecular aspects of disease Dr Camille Ettelaie Dr Rebecca Hill Prof Khalid Naseem Dr Francisco Rivero Dr Elena Rosca Dr Laura Sadofsky Dr Graeme Stasiuk

Cancer biology, metastasis, angiogenesis Diabetic neuropathies Thrombosis and platelet function in health and disease The actin cytoskeleton in health and disease Cancer immunobiology Molecular pharmacology of ion channels Design and synthesis of contrast agents for biological imaging

Genetics Dr Heather Sealy-Lewis Dr Lori Lawson-Handley Dr Isabella Capellini mammals

Gene regulation in Aspergillus nidulans Genetic diversity in human populations Macro-evolutionary patterns and processes of adaptation in

Fertility and Developmental biology Dr Roger Sturmey Metabolic events in early development Medical Microbiology Dr Gavin Paterson Dr Frank Voncken Mrs Chris Murphy

Bacterial pathogens and clinical microbiology Energy metabolism in Trypanosoma brucei Clinical microbiology and infection control

Research project supervisors, affiliation, and e-mail addresses Dr Lynn Cawkwell Mr Ian Chetter Dr Isabella Capellini Dr Chris Cawthorne Dr Charlotte Dyer Dr Camille Ettelaie Prof John Greenman Dr Sandra Jones

SBBES Hull Royal Infirmary SBBES SBBES SBBES SBBES SBBES SBBES

[email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Dr Lori Lawson-Handley Dr Rebecca Hill Prof Khalid Naseem Dr Steven Maher Mrs Chris Murphy Dr Gavin Paterson Dr Isabel Pires Dr Francisco Rivero Dr Elena Rosca Dr Laura Sadofsky Dr Heather Sealy-Lewis Dr Anne-Marie Seymour Dr Graeme Stasiuk Dr Justin Sturge Dr Roger Sturmey Dr Frank Voncken Dr Jennifer Waby Dr Shang-Zhong Xu

SBBES SBBES HYMS SBBES SBBES SBBES SBBES HYMS SBBES SBBES SBBES SBBES SBBES SBBES HYMS SBBES SBBES HYMS

[email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected]

Programme coordinator: Dr Gavin Paterson ([email protected])

Below are the staff in the School of Biological Biomedical and Environmental Sciences, including those whose research interests are outwith the medical-related themes detailed above.

Academic staff & research interests in the School of Biological Biomedical and Environmental Biological Sciences Thomas Breithaupt, Lecturer: Chemical ecology of marine invertebrates. Isabella Capellini, Lecturer: Macro-evolutionary patterns and processes of adaptation in mammals. Integration of the study of morphology, physiology, behaviour and ecology to understand the evolution of mammalian reproduction and life histories, sleep physiology, hibernation and lifespan. Lynn Cawkwell, Senior Lecturer: Cancer biology proteomics. Christpher Cawthorne, Lecturer: Research is focused on the preclinical development of novel imaging biomarkers using Positron Emission Tomography, primarily in oncology. When translated into patients, such agents aim to both aid stratification for targeted therapies as well as to improve the time taken to assess therapeutic efficacy. Charlotte Dyer, Lecturer: Lab on a chip technologies for the diagnosis of disease Mike Elliott, Professor, Director of Institute of Estuarine and Coastal Studies: Biology of estuarine and coastal fish and benthic organisms; ecotoxicology at the individualorganism, population and community level. Roland Ennos, Professor: Engineering of plant and animal structures and on how vegetation can improve the urban environment. Camille Ettelaie, Lecturer: Blood coagulation, thrombosis and haemostasis, mainly concerning cardiovascular disease.

Darren Evans, Lecturer: Impacts of environmental change on the structure and dynamics of ecological networks and the consequences for plant and animal populations. Also terrestrial systems with a focus on food-webs that include plants, insects, mammals and birds. Africa Gomez, Lecturer: Evolutionary ecology of aquatic invertebrates with an emphasis on sexual/asexual mode. John Greenman, Professor and Head of School: Tumour immunology, cancer genetics, prognostic and diagnostic factors. Jorg Hardege, Reader: Reproductive biology and chemical ecology of marine invertebrates. Rebecca Hill, Lecturer: Connective tissue changes in diabetic neuropathy Sandra Jones, Lecturer: Changes in the ageing heart; the intervention of exercise; in terms of ion channel expression and regulation of cell signalling. Domino Joyce, Lecturer: Mechanisms that shape biodiversity; from the effects of selection at individual loci, to the behavioural aspects of mate preference which may cause populations to diverge, and also the larger scale genomic processes involved in adaptive radiations. Lori Lawson-Handley, Lecturer: Human migration and settlement history. David Lunt, Senior Lecturer: Evolutionary genetics; phylogeography; molecular systematics of invertebrates. Stephen Maher, Senior Lecturer: Translational gastrointestinal cancer biology and anticancer therapeutics with a special interest in oesophageal adenocarcinoma, pre-malignant Barrett’s oesophagus and radio-resistance. Chris Murphy, University Teaching Fellow: Mrs Murphy is a clinical microbiologist whose main interest lies in aspects of Infection Control centered mainly around MRSA. In addition she is interested and concerned with professional training for Biomedical Scientists and has been a registered BMS for 19 years, with major roles in both quality and training. Lesley Morrell, Lecturer: Behavioural ecology; evolution of animal aggregation; antipredator behaviour; colour and behaviour; early experience and phenotypic plasticity. Gavin Paterson, Lecturer: Bacterial pathogens; primarily Streptococcus pneumoniae, salmonellae and staphylococci, including methicillin-resistant Staph. aureus (MRSA). A range of topics related to these organisms including bacterial - host pathogens interactions, molecular epidemiology, genomics and antimicrobial resistance. Isabel Pires, Lecturer: Regions of low oxygen or hypoxia occur In all solid tumours and are associated with increased malignancy, resistance to therapy and metastatic potential. My group is interested in investigating novel regulators of this aspect of the tumour microenvironment, particularly regarding the cellular motility of invasion. Eleanor Rosca, Lecturer: Using novel approaches such as micro-fluidic chambers to replicate conditions of the tumour microenvironment and nanoparticles (i.e. liposomes) to trigger specific cellular responses, we can investigate how to specifically modulate the

immune response to specifically target cancerous cells. Jeanette Rotchell: Professor: Molecular ecotoxicology in marine environments Graham Scott, Senior Lecturer: Bird behaviour; the evolutionary ecology of the fucoid algae. Laura Sadofsky: My research focuses on the molecular pharmacology of TRPA1, TRPV1 and TRPM8 (transient receptor potential ankyrin-1, vanilloid-1 and melastatin-8). Heather Sealy-Lewis, Lecturer: Regulation of gene expression in the filamentous fungus, Aspergillus nidulans with special interest in the ethanol utilisation regulon, and carbon catabolite repression. Anne-Marie Seymour, Reader: Biochemical adaptation in cardiac hypertrophy and heart failure using the non-invasive techniques of magnetic resonance spectroscopy; the relationship between heart metabolism and abnormal physiological function and dietary therapeutic treatments; biochemical comparisons between the ageing heart and heart failure. Graeme Stasiuk, Lecturer: Molecular imaging: provides a view of the body at the cellular and sub-cellular level, enabling dynamic visualization of key biological processes within the cell or body. The research in my laboratory is focused on the development of novel contrast agents for use with imaging approaches such as positron emission tomography (PET), single photon emission computed tomography (SPECT), X-ray computed tomography (CT), ultrasound, and magnetic resonance (MR) imaging. Specific research areas include multimodal contrast agents, zinc sensing probes and gallium-68 probes for cancer imaging. Justin Sturge, Senior Lecturer: Research is focused on defining the complex biophysical and molecular networks that exist between cancer cells and the surrounding stroma in primary prostrate and breast carcinoma and their secondary lesions in bone. Frank Voncken, Lecturer: The focus of our research is the unique energy metabolism of the human and veterinary pathogen Trypanosoma brucei, and the functional characterisation of mitochondrial and peroxisomal (glycosomal) metabolite transporters. The obtained results will lead to: a better understanding of the energy metabolism of the parasite, the design of more effective anti-parasitic drugs, and the functional identification of corresponding human metabolite transporters related to different metabolic diseases. Jennifer Waby, Lecturer: The role of the Sp family of transcription factors in cell cycle control and cancer. Regulation of Sp transcription factor activity by post translational modifications.





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