BIOGRAPHICAL SKETCH NAME

POSITION TITLE

Ellen Kuhl

Associate Professor of Mechanical Engineering, Bioengineering (courtesy), Cardiothoracic Surgery (courtesy)

eRA COMMONS USER NAME

ELLEN.KUHL EDUCATION/TRAINING INSTITUTION AND LOCATION

DEGREE (if applicable)

YEAR(s)

FIELD OF STUDY

Technical University of Kaiserslautern, Germany

Habilitation

2004

Biomechanical Engineering

Delft University of Technology, The Netherlands

Post Doc

2000

Aerospace Engineering

University of Stuttgart, Germany

PhD

2000

Civil Engineering

Leibniz University of Hannover, Germany

Diploma

1995

Computational Engineering

A. Personal Statement I am an Associate Professor of Mechanical Engineering, Bioengineering (courtesy), and Cardiothoracic Surgery (courtesy). My area of professional expertise is living matter physics, the creation of theoretical and computational models to predict the acute and chronic response of living structures to environmental changes during development and disease progression. My specific interest is the multiscale modeling of growth and remodeling, the study of how living matter adapts its form and function to changes in mechanical loading, and how this adaptation can be traced back to structural alterations on the cellular or molecular levels. Growth and remodeling might be induced naturally, e.g., through elevated pressure, stress, or strain, or interventionally, e.g., through tissue expansion, prostheses, stents, tissue grafts, or stem cell injection. Combining theories of electrophysiology, photoelectrochemistry, biophysics, and continuum mechanics, my lab has specialized in predicting the chronic loss of form and function in growing and remodeling soft tissue using subject-specific custom-designed finite element models. B. Positions and Honors. Positions and Employment 2010Associate Professor Departments of Mechanical Engineering, Bioengineering (courtesy), and Cardiothoracic Surgery (courtesy), Stanford University 2011 Professor Department of Mechanical Engineering, ETH Zurich 2007-2009 Assistant Professor Departments of Mechanical Engineering and Bioengineering (affiliation), Stanford University 2002-2006 Assistant Professor Department of Mechanical Engineering, TU Kaiserslautern, Germany Honors and Awards 2010 CAREER Award, National Science Foundation (NSF) 2009 Hellman Faculty Scholar 2001 Habilitation Research Fellowship, German Science Foundation (DFG) 1996 Graduate Research Fellowship, German Science Foundation (DFG) Other Experience and Professional Memberships • Editorial Board: Acta Mechanica Sinica, Applied Mechanics Reviews,   Computer Methods in Biomechanics and Biomedical Engineering, International Journal for Numerical Methods in Biomedical Engineering, Journal of Computational Surgery, Journal of the Mechanics and Physics of Solids • Reviewer: Acta Biomaterialia, American Journal of Physiology Heart and Circulatory Physiology, Annals of Biomedical Engineering, Archive of Applied Mechanics, Biomechanics and Modeling in Mechanobiology, Cardiovascular Engineering and Technology, Computational Materials Science, Computational Mechanics, Computer Methods in Applied Mechanics and Engineering, Computer Methods in Biomechanics and 1

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Biomedical Engineering, Computer Methods and Programs in Biomedicine, Computers and Concrete, Continuum Mechanics and Thermodynamics, Encyclopedia of Computational Mechanics, Engineering and Computational Mechanics, Engineering Computations, Engineering with Computers, European Journal of Mechanics, Experimental Biology and Medicine, Frontiers in Computational Physiology and Medicine, International Journal for Numerical and Analytical Methods in Geomechanics, International Journal for Numerical Methods in Biomedical Engineering, International Journal for Numerical Methods in Engineering, International Journal of Engineering Science, International Journal of Mechanics of Materials and Structures, International Journal of Non-Linear Mechanics, International Journal of Solids and Structures, International Journal of Applied Mathematics and Mechanics, Journal of Applied Mechanics, Journal of Biological Dynamics, Journal of Biomechanics, Journal of Computational Physics, Journal of Elasticity, Journal of Engineering Mechanics, Journal of Mechanics of Materials and Structures, Journal of Multiscale Computational Engineering, Journal of the Royal Society Interface, Journal of Structural Changes in Solids, Journal of the Mechanical Behavior of Biomedical Materials, Journal of the Mechanics and Physics of Solids, Journal of Theoretical Biology, Nature Materials, Mechanics Research Communications, Medical Engineering and Physics, PLoS Computational Biology, PLoS ONE, Proceedings of the National Academy of Sciences PNAS, Proceedings in Applied Mathematics and Mechanics, Proceedings of the Royal Society London, Philosophical Magazine Scientific Reviewer: National Institutes of Health (NIH), National Science Foundation (NSF), American Heart Association (AHA), German Science Foundation (DFG), Israel Science Foundation (ISF), Swiss National Science Foundation (SFN) Guest Editor: Frontiers in Finite-Deformation Electromechanics, European Journal of Mechanics, Vol 48, 2014; Growing Matter, Journal of the Mechanical Behavior of Biomedical Materials, Vol 29, 2014; Recent Advances in the Biomechanics of Growth and Remodeling, Mechanics Research Communications, Vol 42, 2012; Active Tissue Modeling: From Single Muscle Cells to Muscular Contraction, International Journal of Multiscale Computational Engineering, Vol 10, 2012; Mechanics in Biology: Cells and Tissues, Philosophical Transactions of the Royal Society London, Vol 369, 2009; Computer Simulations of Mechanobiology, Computer Methods in Biomechanics and Biomedical Engineering, Vol 11, 2008. Workshop, Symposia, and Session Organization: 7th World Congress of Biomechanics, Track-Co-Chair, Boston, MA, 2014; IUTAM Symposium on Computer Methods in Biomechanics: From Nano to Macro, Stanford, CA, 2011; Minisymposium on Computational Modeling of Electro-Active Materials, WCCM IX, Adelaide, Australia, 2010; Minisymposium on Active Tissue Modeling from Single Muscle Cells to Muscular Contraction, USNCCM X, Columbus, OH, 2009, IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, Woods Hole, MA, 2008; Miniworkshop on the Mathematics of Growth and Remodeling of Soft Biological Tissues, Oberwolfach, Germany, 2008; Minisymposium on Growth and Remodeling, USNCCM IX, San Francisco, CA, 2007; Minisymposium on Multiscale Modeling of Materials, USNCCM IX, San Francisco, CA, 2007; Biomechanics, GAMM Annual Meeting, Berlin, 2006. Committees: Secretary/Treasurer, US National Committee on Biomechanics (since 2013); Chair of Graduate Admission, Department of Mechanical Engineering, Stanford University (since 2012). Memberships: American Heart Association (AHA), American Physical Society (APS), American Society of Engineering Education (ASEE), American Society of Mechanical Engineers (ASME), Biomedical Engineering Society (BMES), Biophysical Society (BPS), European Society of Biomechanics (ESB), European Mechanics Society (EUROMECH), German Association for Applied Mathematics and Mechanics (GAMM), International Association for Computational Mechanics (IACM), US Association for Computational Mechanics (USACM)

C. Peer-reviewed publications underlined: Kuhl’s students and postdocs 1. Budday S, Steinmann P, Goriely A, Kuhl E. Size and curvature regulate pattern selection in the mammalian brain. Extr Mech Lett. doi:10.1016/j.eml.2015.07.004. 2. Goriely A, Geers MGD, Holzapfel GA, Jayamohan J, Jerusalem A, Sivaloganathan S, Squier W, van Dommelen JAW, Waters S, Kuhl E. Mechanics of the brain: Perspectives, challenges, and opportunities. Biomech Mod Mechanobio. doi:10.1007/s10237-015-0662-4. 3. Javili A, Dortdivanlioglu B, Kuhl E, Linder C. Computational aspects of growth-induced instabilities. Comp Mech. doi:10.1007/s00466-015-1178-6. 4. Genet M, Lee LC, Baillargeon B, Guccione JM, Kuhl E. Modeling pathologies of systolic and diastolic heart failure. Ann Biomed Eng. doi: 10.1007/s10439-015-1351-2. 2

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Eskandari M, Kuschner WG, Kuhl E. Patient-specific airway wall remodeling in chronic lung disease. Ann Biomed Eng. doi:10.1007/s10439-015-1306-7. Budday S, Steinmann P, Kuhl E. Secondary instabilities modulate cortical complexity in the mammalian brain. Phil Mag. doi:10.1080/14786435.2015.1024184. Budday S, Kuhl E, Hutchinson JW. Period-doubling and period-tripling in growing bilayered systems. Phil Mag. doi:10.1080/14786435.2015.1014443. Buganza Tepole A, Gart M, Purnell CA, Gosain AK, Kuhl E. Multi-view stereo analysis reveals anisotropy of prestrain, deformation, and growth in living skin. Biomech Mod Mechanobio. doi:10.1007/s10237-0150650-8. Buganza Tepole A, Kuhl E. Computational modeling of chemo-bio-mechanical coupling: A systemsbiology approach towards wound healing. Comp Meth Biomech Biomed Eng. doi:10.1080/10255842.2014.980821. Budday S, Steinmann P, Kuhl E. Physical biology of human brain development. Front Cell Neurosci. 2015;9:257. Buganza Tepole A, Kabaria H, Bletzinger KU, Kuhl E. Isogeometric Kirchhoff-Love shell formulations for biological membranes. Comp Meth Appl Mech Eng. 2015;293:328-347. Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM. Human cardiac function simulator for the optimal design of a novel annuloplasty ring with a sub-valvular element for correction of ischemic mitral regurgitation. Cardiovasc Eng Tech. 2015;6:105-116. Genet M, Rausch MK, Lee LC, Choy S, Zhao X, Kassab GS, Kozerke S, Guccione JM, Kuhl E. Heterogeneous growth-induced prestrain in the heart. J Biomech. 2015;48:2080-2089. Holland MA, Miller KE, Kuhl E. Emerging brain morphologies from axonal elongation. Ann Biomed Eng. 2015;43:1640-1653. Wong J, Kuhl E, Darve E. A new sparse matrix vector multiplication GPU algorithm designed for finite element problems. Int J Num Meth Eng. 2015;102:1784-1814. Budday S, Nay R, de Rooij R, Steinmann P, Wyrobek T, Ovaert TC, Kuhl E. Mechanical properties of gray and white matter brain tissue by indentation. J Mech Behavior Biomed Mat. 2015;46:318-330. Raaz U, Zollner AM, Schellinger IN, Toh R, Nakagami F, Brandt M, Emrich FC, Kayama Y, Eken S, Adam M, Maegdefessel L, Hertel T, Deng A, Jagger A, Buerke M, Dalman RL, Spin JM, Kuhl E, Tsao PS. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development. Circulation. 2015;131:1783-1795. Balbi V, Kuhl E, Ciarletta P. Morphoelastic control of gastro-intestinal organogenesis: theoretical predictions and numerical insights. J Mech Phys Solids. 2015;78:493-510. Wisdom KM, Delp SL, Kuhl E. Use it or lose it: Multiscale skeletal muscle adaptation to mechanical stimuli. Biomech Mod Mechanobio. 2015;14:195-215. Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E. A computational model predicts reverse growth in response to mechanical unloading. Biomech Model Mechanobio. 2015;14:217-229. Zollner AM, Pok JM, McWalter EJ, Gold GE, Kuhl E. On high heels and short muscles: A multiscale model for sarcomere loss in the gastrocnemius muscle. J Theor Bio. 2015;365:301–310. Checa S, Rausch MK, Petersen A, Kuhl E, Duda GN. The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization. Biomech Mod Mechanobio. 2015;14:1-13. Ciarletta P, Balbi V, Kuhl E. Pattern selection in growing tubular tissues. Phys Rev Lett. 2014;113:248101. Buganza Tepole A, Gart M, Gosain AK, Kuhl E. Characterization of living skin using multi view stereo and isogeometric analysis. Acta Biomat. 2014;10:4822-4831. Buganza Tepole A, Steinberg JP, Kuhl E, Gosain AK. Application of finite element modeling to optimize flap design with tissue expansion. Plast Reconstr Surgery. 2014;134:785-792. Budday S, Steinmann P, Kuhl E. The role of mechanics during brain development. J Mech Phys Solids. 2014;72:75-92. Goktepe S, Menzel A, Kuhl E. The generalized Hill model: A kinematic approach towards active muscle contraction. J Mech Phys Solids. 2014;72:20-39. Baillargeon B, Rebelo N, Fox DD, Taylor RL, Kuhl E. The Living Heart Project: A robust and integrative simulator for human heart function. Eur J Mech A/Solids. 2014;48:38-47. 3

29. Vogel F, Göktepe S, Steinmann P, Kuhl E. Modeling and simulation of viscous electro-active polymers. Eur J Mech A/Solids. 2014;48:112-128. 30. Buganza Tepole A, Gosain AK, Kuhl E. Computational modeling of skin: Using stress profiles as predictor for tissue necrosis in reconstructive surgery. Comp & Struct. 2014;143:32-39. 31. Budday S, Raybaud C, Kuhl E. A mechanical model predicts morphological abnormalities in the developing human brain. Sci Rep. 2014;4:5644. 32. Saez P, Pena E, Martinez MA, Kuhl E. Computational modeling of hypertensive growth in the human carotid artery. Comp Mech. 2014;53:1183-1196. 33. Wong J, Kuhl E. Generating fiber orientation maps in human heart models using Poisson interpolation. Comp Meth Biomech Biomed Eng. 2014;17:1217-1226. 34. Hurtado D, Kuhl E. Computational modeling of electrocardiograms: Repolarization and T-wave polarity in the human heart. Comp Meth Biomech Biomed Eng. 2014;17:986-996. 35. Rausch MK, Kuhl E. On the mechanics of growing thin biological membranes. J Mech Phys Solids. 2014;63:128-140. 36. Kuhl E. Growing matter - A review of growth in living systems. J Mech Behavior Biomed Mat. 2014;29:529-543. 37. Javili A, Steinmann P, Kuhl E. A novel strategy to identify the critical conditions for growth-induced instabilities. J Mech Behavior Biomed Mat. 2014;29:20-32. 38. Eskandari M, Pfaller MR, Kuhl E. On the role of mechanics in chronic lung disease. Materials. 2013;6:5639-5658. 39. Zollner AM, Holland MA, Honda KS, Gosain AK, Kuhl E. Growth on demand - Reviewing the mechanobiology of stretched skin. J Mech Behavior Biomed Mat. 2013;28:495-509. 40. Saez P, Pena E, Martinez MA, Kuhl E. Mathematical modeling of collagen turnover in biological tissue. J Math Bio. 2013;67:1765-1793. 41. Wong J, Goktepe S, Kuhl E. Computational modeling of chemo-electro-mechanical coupling: A novel implicit monolithic finite element approach. Int J Num Meth Biomed Eng. 2013;29:1104-1133. 42. Rausch MK, Famaey N, O'Brien Shultz T, Bothe W, Miller DC, Kuhl E. Mechanics of the mitral valve: A critical review, an in vivo parameter identification, and the effect of prestrain. Biomech Mod Mechanobio. 2013;12:1053-1071. 43. Rausch MK, Tibayan FA, Ingels NB, Miller DC, Kuhl E. Mechanics of the mitral annulus in chronic ischemic cardiomyopathy. Ann Biomed Eng. 2013;41:2171-2180. 44. Rausch MK, Kuhl E. On the effect of prestrain and residual stress in thin biological membranes. J Mech Phys Solids. 2013;61:1955-1969. 45. Holland MA, Kosmata T, Goriely A, Kuhl E. On the mechanics of thin films and growing surfaces. Math Mech Solids. 2013;18:561-575. 46. Papastavrou A, Steinmann P, Kuhl E. On the mechanics of continua with boundary energies and growing surfaces. J Mech Phys Solids. 2013;61:1446-1463. 47. Buganza Tepole A, Kuhl E. Review: Systems-based approaches towards wound healing. Pediatric Res, 2013;73:553-563. 48. Chen MQ, Wong J, Kuhl E, Giovangrandi LB, Kovacs GTA. Characterization of electrophysiological conduction in cardiomyocyte co-cultures using co-occurrence analysis. Comp Meth Biomech Biomed Eng, Comp Meth Biomech Biomed Eng, 2013;16:185-197. 49. Famaey N, Vander Sloten J, Kuhl E. A three-constituent damage model for arterial clamping in computerassisted surgery. Biomech Mod Mechanobio, 2013;12:123-136. 50. Dal H, Goktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electromechanics. Comp Meth Appl Mech Eng, 2013;253:323-336. 51. Rausch MK, Tibayan FA, Miller DC, Kuhl E. Evidence of adaptive mitral leaflet growth. J Mech Behavior Biomed Mat, 2012;15:208-217. 52. Zollner AM, Abilez OJ, Bol M, Kuhl E. Stretching skeletal muscle - Chronic muscle lengthening through sarcomerogenesis. PLoS ONE, 2012;7(10):e45661. 53. Bothe W, Rausch MK, Kvitting JP, Echtner DK, Walther M, Ingels NB, Kuhl E, Miller DC. How do annuloplasty rings affect mitral annular strains in the normal beating ovine heart? Circulation, 2012;126: S231-S238. 54. Buganza Tepole A, Gosain AK, Kuhl E. Stretching skin - The physiological limit and beyond. Int J Nonlin Mech, 2012;47:938-949. 4

55. Zollner AM, Buganza Tepole A, Gosain AK, Kuhl E. Growing skin - Tissue expansion in pediatric forehead reconstruction. Biomech Mod Mechanobio, 2012;11:855-867. 56. Waffenschmidt T, Menzel A, Kuhl E. Anisotropic density growth of bone. A computational micro-sphere approach. Int J Solids Structures, 2012;49:1928-1946. 57. Menzel A, Kuhl E. Frontiers in growth and remodeling. Mech Res Comm, 2012;42,1-14. 58. Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM. Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration. Mech Res Comm, 2012;42,134-141. 59. Dal H, Goktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electrophysiology. Comp Meth Biomech Biomed Eng, 2012;15,645-656. 60. Bol M, Abilez OJ, Assar AN, Zarins CK, Kuhl E. In vitro / in silico characterization of active and passive stresses in cardiac muscle. Int J Multiscale Comp Eng, 2012;10:171-188. 61. Wong J, Abilez OJ, Kuhl E. Computational optogenetics - A novel continuum framework for the photoelectrochemistry of living systems. J Mech Phys Solids, 2012;60:1158-1178. 62. Schmid H, Pauli L, Paulus A, Kuhl E, Itskov M. How to utilise the kinematic constraint of incompressibility for modelling adaptation of soft tissues. Comp Meth Biomech Biomed Eng, 2012;15:547-561. 63. Tsamis A, Cheng A, Nguyen TC, Langer F, Miller DC, Kuhl E. Kinematics of cardiac growth - In vivo characterization of growth tensors and strains. J Mech Behavior Biomed Mat, 2012;8:165-177. 64. Zollner AM, Buganza Tepole A, Kuhl E. On the biomechanics and mechanobiology of growing skin. J Theor Bio, 2012;297:166-175. 65. Rausch MK, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Mitral valve annuloplasty - A quantitative comparison of different annuloplasty devices. Ann Biomed Eng, 2012;40:750-761. 66. Pang H, Shiwalkar AP, Madormo CM, Taylor RE, Andriacchi TP, Kuhl E. Computational modeling of bone density profiles in response to gait. Biomech Mod Mechanobio, 2012;11:379-390. 67. Rausch MK, Dam A, Goktepe S, Abilez OJ, Kuhl E. Computational modeling of growth: Systemic and pulmonary hypertension in the heart. Biomech Mod Mechanobio, 2011;10:799-811. 68. Buganza Tepole A, Ploch CJ, Wong J, Gosain AK, Kuhl E. Growing skin - A computational model for skin expansion in reconstructive surgery. J Mech Phys Solids,2011;59:2177-2190. 69. Wong J, Goktepe S, Kuhl E. Computational modeling of electrochemical coupling: A novel finite element approach towards ionic models for electrophysiology. Comp Meth Appl Mech Eng, 2011;200:3139-3158. 70. Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E. Multiscale computational models for optogenetic control of cardiac function. Biophys J, 2011;101:1326-1334. 71. Bothe W, Kuhl E, Kvitting JP, Rausch MK, Goktepe S, Swanson JC, Farahmandnia S, Ingels NB, Miller DC. Rigid, complete annuloplasty rings increase anterior mitral leaflet strains in the normal beating ovine heart. Circulation, 2011;124:S81-S96. 72. Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. Ann Thorac Surg, 2011;92:935-941. 73. Tsamis A, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Active contraction of cardiac muscle: In vivo characterization of mechanical activation sequences in the beating heart. J Mech Behavior Biomed Mat, 2011;4:1167-1176. 74. Rausch MK, Bothe W, Kvitting JP, Swanson JC, Ingels NB, Miller DC, Kuhl E. Characterization of mitral valve annular dynamics in the beating heart. Ann Biomed Eng, 2011;39:1690-1702. 75. Rausch MK, Bothe W, Kvitting JP, Goktepe S, Miller DC, Kuhl E. In vivo dynamic strains of the ovine anterior mitral valve leaflet. J Biomechanics, 2011;44:1149-1157. 76. Ambrosi D, Ateshian GA, Arruda EM, Cowin SC, Dumais J, Goriely A, Holzapfel GA, Humphrey JD, Kemkemer R, Kuhl E, Olberding JE, Taber LA, Garikipati K. Perspectives on biological growth and remodeling. J Mech Phys Solids, 2011;59:863-883. 77. Goktepe S, Acharya SNS, Wong J, Kuhl E. Computational modeling of passive myocardium. Int J Num Meth Biomed Eng, 2011;27:1-12. 78. Kvitting JP, Bothe W, Goktepe S, Rausch MK, Swanson JC, Kuhl E, Ingels NB, Miller DC. Anterior mitral leaflet curvature during the cardiac cycle in the normal ovine heart. Circulation, 2010;122:1683-1689. 79. Goktepe S, Abilez OJ, Kuhl E. A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening. J Mech Phys Solids, 2010;58:1661-1680. 5

80. Goktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Bio, 2010;265:433-442. 81. Rajagopal A, Fischer P, Kuhl E, Steinmann P. Natural element analysis of the Cahn-Hilliard phase-field model. Comp Mech, 2010;46:471-493. 82. Goktepe S, Bothe W, Kvitting JP, Swanson J, Ingels NB, Miller DC, Kuhl E. Anterior mitral leaflet curvature in the beating ovine heart. Biomech Mod Mechanobio. 2010;9:281-293. 83. Kotikanyadanam M, Goktepe S, Kuhl E. Computational modeling of electrocardiograms - A finite element approach towards cardiac excitation. Int J Num Meth Biomed Eng. 2010;26:524-533. 84. Goktepe S, Wong J, Kuhl E. Atrial and ventricular fibrillation - Computational simulation of spiral waves in cardiac tissue. Arch Appl Mech. 2010;80:569-580. 85. Zhang J, Michalenko MM, Kuhl E, Ovaert TC. Characterization of indentation response and stiffness reduction of bone. J Mech Behavior Biomed Mat. 2010;3:189-202. 86. Goktepe S, Kuhl E. Electromechanics of cardiac tissue: A unified approach to the fully coupled excitationcontraction problem. Comp Mech. 2010;45:227-243. 87. Gitman I, Askes H, Kuhl E, Aifantis EC. Stress concentrations in fractured compact bone simulated with a special class of anisotropic gradient elasticity. Int J Solids Structures. 2010;47:1099-1107. 88. Krishnamurthy G, Itoh A, Swanson J, Bothe W, Karlsson M, Kuhl E, Miller DC, Ingels NB. Regional stiffening of the mitral valve anterior leaflet in the beating heart. J Biomechanics, 2009;42:2697-2701. 89. Jager P, Steinmann S, Kuhl E. Towards the treatment of boundary conditions for global crack path tracking in three-dimensional brittle fracture. Comp Mech. 2009;45:91-107. 90. Krishnamurthy G, Itoh A, Bothe W, Swanson J, Kuhl E, Karlsson M, Miller DC, Ingels NB. Stress-strain behavior of mitral valve leaflets in the beating ovine heart. J Biomechanics. 2009;42:1909-1916. 91. Itoh A, Krishnamurthy G, Swanson J, Ennis DB, Bothe W, Kuhl E, Karlsson M, Davis L, Miller DC, Ingels NB. Active stiffening of mitral valve leaflets. Am J Physiol Heart Circ Physiol. 2009;296:1766-1773. 92. Goktepe S, Kuhl E. Computational modeling of electrophysiology: A novel finite element approach. Int J Num Meth Eng. 2009;79:156-178. 93. Bol M, Reese S, Parker KK, Kuhl E. Computational modeling of muscular thin films for cardiac repair. Comp Mech. 2009;43:535-544. 94. Taylor RE, Zheng C, Jackson PR, Doll JC, Chen JC, Holzbaur KRS, Besier T, Kuhl E. The phenomenon of twisted growth: Humeral torsion in dominant arms of high performance tennis players. Comp Meth Biomech Biomed Eng. 2009;12:83-93. 95. Krishnamurthy G, Ennis DB, Itoh A, Bothe W, Swanson-Birchill JC, Karlsson M, Kuhl E, Miller DC, Ingels NB. Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis. Am J Physiol Heart Circ Physiol. 2008;295:H1141-H1149. 96. Jha CM, Salvia J, Chandorkar SA, Melamud R, Kuhl E, Kenny TW. Acceleration insensitive encapsulated silicon microresonator. Appl Phys Let. 2008;93:234103.1-234103.3. 97. Jager P, Schmalholz SM, Schmid DW, Kuhl E. Brittle fracture during folding rocks - A finite element study. Phil Mag. 2008;88:3245-3263. 98. Meier HA, Schlemmer M, Wagner C, Kerren A, Hagen H, Kuhl E, Steinmann P. Visualization of particle interactions in granular media. IEEE Trans Vis Comp Graphics. 2008;14:1-16. 99. Jager P, Steinmann P, Kuhl E. Modeling three-dimensional crack propagation - A comparison of crack path tracking strategies. Int J Num Meth Eng. 2008;76:1328-1352. 100. Himpel G, Menzel A, Kuhl E, Steinmann P. Time-dependent fiber reorientation of transversely isotropic continua, Int J Num Meth Eng. 2008; 73:1413-1433. 101. Jager P, Steinmann S, Kuhl E. On local tracking algorithms for the simulation of three-dimensional discontinuities, Comp Mech. 2008;42:395-406. 102. Meier HA, Kuhl E, Steinmann P. A note on the generation of periodic granular microstructures based on grain size distributions, Int J Num Anal Meth Geomech. 2008;32:509-522. 103. Utzinger J, Bos M, Floeck M, Menzel A, Kuhl E, Renz R, Friedrich K, Schlarb AK, Steinmann P. Computational modelling of thermal impact welded PEEK/steel single lap tensile specimens, Comp Mat Sci. 2008;41:287-296. 104. Meier HA, Steinmann P, Kuhl E. Towards mulitscale computation of confined granular media - Contact forces, stresses and tangent operators, Techn Mech. 2008;28:32-42. 105. Kuhl E, Holzapfel GA. A continuum model for remodeling in living structures, J Mater Sci. 2007;42,88118823. 6

106. Hauret P, Kuhl E, Ortiz M. Diamond elements: A finite-element/discrete mechanics approximation scheme with guaranteed convergence, Int J Num Meth Eng. 2007;72: 253-294. 107. Kuhl E, Maas R, Himpel G, Menzel A. Computational modeling of arterial wall growth: Attempts towards patient specific simulations based on computer tomography, Biomech Mod Mechanobio. 2007;6:321-331. 108. Hirschberger CB, Kuhl E, Steinmann P. On deformational and configurational mechanics of micromorphic hyperelasticity, Comp Meth Appl Mech Eng. 2007;196,4027-4044. 109. Kuhl E, Schmid DW. Computational modeling of mineral unmixing and growth: An application of the Cahn-Hilliard equation, Comp Mech. 2007;39:439-451. 110. Mergheim J, Kuhl E, Steinmann P. Towards the algorithmic treatment of 3D strong discontinuities, Comm Num Meth Eng. 2007;23:97-108. 111. Kuhl E, Menzel A, Garikipati, K. On the convexity of transversely isotropic chain network models, Phil Mag. 2006;86:3241-3258. 112. Kuhl E, Askes H, Steinmann P. An illustration of the equivalence of the loss of ellipticity conditions in spatial and material settings of hyperelasticity, Eur J Mech/A Solids 25: 199-214, 2006. 113. Wells GN, Kuhl E, Garikipati K. A discontinuous Galerkin method for the Cahn-Hilliard equation, J Comp Phys. 2006;218:860-877. 114. Himpel G, Kuhl E, Menzel A, Steinmann P. Computational modelling of isotropic multiplicative growth, Comp Mod Eng Sci. 2005;8:119-134. 115. Kuhl E, Garikipati K, Arruda EA, Grosh K. Remodeling of biological tissue: Mechanically induced reorientation of a transversely isotropic chain network, J Mech Phys Solids: 53, 1552-1573, 2005. 116. Kuhl E, Balle F. Computational modeling of hip replacement surgery: total hip replacement vs. hip resurfacing, Tech Mech. 25. 2005;107-114. 117. Kuhl E, Steinmann P. A hyperelastodynamic ALE formulation based on referential, spatial and material setting of continuum mechanics, Acta Mechanica. 2005;174: 201-222. 118. Askes H, Bargmann S, Kuhl E, Steinmann P. Structural optimisation by simultaneous equilibration of spatial and material forces, Comm Numer Meth Eng. 2005;21:433-442. 119. Mergheim J, E Kuhl, Steinmann P. A finite element method for the computational modeling of cohesive crack, Int J Num Meth Eng. 2005;63:276-289. 120. Kuhl E, Steinmann P. Material forces in open system mechanics, Comp Meth Appl Mech Eng. 2004;193: 2357-2381. 121. Kuhl E, Denzer D, Barth FJ, Steinmann P. Application of the material force method to thermohyperelasticity, Comp Meth Appl Mech Eng. 2004;193:3303-3326. 122. Mergheim J, Kuhl E, Steinmann P. A hybrid discontinuous Galerkin/interface method for the computational modeling of failure, Comm Numer Meth Eng. 2004;20:511-519. 123. Kuhl E, Denzer D, Barth FJ, Steinmann P. Application of the material force method to thermohyperelasticity, Comp Meth Appl Mech Eng. 2004;193:3303-3326. 124. Kuhl E, Askes H, Steinmann P. An ALE formulation based on spatial and material settings of continuum mechanics. Comp Meth Appl Mech Eng 193, 4207-4222, 2004. 125. Kuhl E, Steinmann P. Computational modeling of healing: An application of the material force method, Biomech Modeling Mechanobiology 2: 187-203, 2004. 126. Kuhl E, Menzel A, Steinmann P. Computational modeling of growth: A critical review, a classification of concepts and two new consistent approaches, Comp Mech. 2003;32:71-88. 127. Kuhl E, Steinmann P. Theory and numerics of geometrically non-linear open system mechanics, Int J Num Meth Eng. 2003;58:1593-1615. 128. Kuhl E, Steinmann P. Mass-and volume specific views on thermodynamics of open systems, Proc Roy Soc London. 2003;459:2547-2568. 129. Kuhl E, Steinmann P. On spatial and material settings of thermo-hyperlastodynamics for open systems, Acta Mech. 2003;160:179-217. 130. Kuhl E, Hulshoff S, de Borst R. An arbitrary Lagrangian-Eulerian finite-element approach for fluidstructure interaction phenomena, Int J Num Meth Eng. 2003;57:117-142. 131. Kuhl E, Carol I, Steinmann P. New thermodynamic approach to microplane model. Part II: Dissipation and inelastic constitutive modeling, Int J Solids Structures. 2001;38:2933-2952. 132. Kuhl E, Ramm E, de Borst R. An anisotropic gradient damage model for quasi-brittle materials, Comp Meth Appl Mech Eng. 2000;183:87-103. 7

133. Kuhl E, Ramm E, Willam KJ. Failure analysis of elasto-plastic material models on different levels of observation, Int J Solids Structures. 2000;37:7259-7280. 134. Kuhl E, D’Addetta GA, Herrmann HJ, Ramm E. A comparison of discrete granular material models with continuous microplane formulations, Granular Matter. 2000;2:123-135. 135. Kuhl E, Ramm E. Microplane modeling of cohesive frictional materials, Eur J Mech/A Solids. 2000;19: 121-149. 136. Mahnken R, Kuhl E. Parameter identification of gradient enhanced damage models with the finite element method, Eur J Mech/A: Solids. 1999;18:819-835. 137. Kuhl E, Ramm E. Simulation of strain localization with gradient enhanced damage models, Comp Mat Sci. 1999;16:176-185. 138. Kuhl E, Ramm E. On the linearization of the microplane model, Mech Coh Frict Mat. 1998;3:343-364. 139. Steinmann P, Kuhl E, Stein E. Aspects of non-associated single crystal plasticity: Influence of NonSchmid effects and localization analysis. Int J Solids Structurs. 1998;35:4437-4456. 140. Sawischlewski E, Steinmann P, Stein E. Modelling and computations of instability phenomena in multisurface plasticity. Comp Mech. 1996;18:245-258. D. Research Support Ongoing Research Support •

NIH U01 HL119578, PIs Guccione, Kassab, Kuhl $2,500,000 07/25/14-06/30/19 Title: Multi-scale laws of myocardial growth and remodeling. Goal: This study will provide functional insight into cardiac growth and remodeling using animal models.

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BIO-X IIP 7, PI Kuhl $200,000 10/01/14-09/30/16 Title: Understanding gyrification dynamics in the human brain. Goal: This research provides a correlation between gyrification and autism spectrum disorders.

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NSF INSPIRE 1233054, PI Kuhl $600,000 08/15/12-08/14/15 Title: Optogenetic control of the human heart – Turning light into force. Goal: This project focuses on creating a biological pacemaker from genetically engineered heart cells.

Completed Research Support •

NSF CAREER 0952021, PI Kuhl $400,000 02/01/10-01/31/15 Title: The Virtual Heart – Exploring the structure-function relationship in electroactive cardiac tissue. Goal: This study provides a multiscale computational toolbox to simulate excitation-contraction coupling.

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NSF EFRI-CBE 0735551, PI Pruitt, co-PIs Heilshorn, Kuhl, Wu, Zarins 09/01/07-08/31/12 Title: Engineering of cardiovascular cellular interfaces and tissue constructs. Goal: This project is targeted at designing tissue-engineered grafts for cardiac repair after infarction.

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NSF CMMI 1050504, PI Kuhl 04/01/11-03/31/12 Title: IUTAM Symposium on Computer Models in Biomechanics: From Nano to Macro. Goal: This grant is supporting a multiscale modeling symposium from 08/29 to 09/02/2011 at Stanford.

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NIH HL086400, PI Guccione, co-PIs Kassab, McCulloch, Ratcliffe et al., consultant Kuhl 05/01/09-04/30/11 Title: Simulation of coronary artery bypass grafting and surgical ventricular restauration Goal: This project focuses on the simulation of different surgical interventions to treat heart failure.

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Hellman Faculty Scholar, PI Kuhl 09/01/09-08/31/10 Title: A new predictive multiscale simulation tool for heart failure. Goal: This study provides a computational tool to simulate progressive dilation and caradiac growth.

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Bio-X IIP 4, PI Heilshorn, co-PIs Kuhl, Zarins 09/01/08-08/31/10 Title: An integrated approach to cardiac repair: Computational models, biomaterials, and stem cell. Goal: This experimental/computational project will investigate the potential of stem cell injection in rodents.

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NIH 5U54GM072970, Seed Grant within NIH Center SIMBIOS, PI Kuhl 10/01/07-03/31/08 Title: SimGrowth - A virtual lab for myocardial infarction and restoration of cardiac function Goal: This seed grant provided the basis for this NIH proposal on modeling cardiac growth in heart failure. 8