DRIfocus

Diabetes Research Institute Foundation Fall 2012 / Volume 40 / Issue 1

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BIOENGINEERING BETTER OPTIONS FOR A BIOLOGICAL CURE

Engineers design things. They apply their respective expertise in physics, chemistry, computer science, biology and more to build structures, devices, systems and materials to solve real-world problems. At the Diabetes Research Institute, tissue and bioengineers work to overcome the hurdles in cell replacement therapy and play a key role in our effort to discover a biological cure. Tissue engineering uses a combination of cells, engineering principles, biomaterials and biochemical factors to improve or replace biological function. Today, with advances in materials science and cell-based therapies, tissue engineering has entered a whole new era and one that is central to many life-saving clinical applications. The DRI’s tissue and bioengineering teams are at the center of one of the most important initiatives underway at the Institute – the development of a mini organ that mimics the native pancreas. Working together with other DRI colleagues, like immunologists, molecular and cell biologists, transplant surgeons, clinical researchers and others, the team is focusing on several pieces of the puzzle that will help to overcome the challenges faced with current islet transplantation procedures. Among these is the need to identify an optimal site within the body to house transplanted cells. DRI scientists and collaborators have already shown that transplanted islets can restore natural insulin production in patients with type 1 diabetes, and that the cells can function long term. Islets are currently transplanted into the liver, but this site is not ideal for a number of reasons. That’s where tissue engineering comes in. The DRI team is engineering new sites within the body to house insulin-producing cells, among them a bioengineered, sponge-like scaffold (see related stories on pages 9-11). In fact, clinical trials using the scaffold are expected to begin next year. But an alternate site must do more than simply house transplanted cells. The native pancreatic environment provides critical levels of nutrients and other factors that sustain healthy islet function. For example, islets need an abundance of oxygen, so DRI researchers are developing and testing special biomaterials to supply the cells with this vital element at the time of and immediately post-transplant. Islets also need protection from the immune system. So the DRI teams are developing special coatings to encase the cells with an ultra-thin protective barrier. The researchers are also working with biomaterials to deliver low-dose anti-rejection drugs locally, at the site of the transplant, instead of throughout the entire body. Recent progress in these areas and more were presented by several DRI scientists last month, including Peter Buchwald, Ph.D., Maria Coronel, Ph.D., Kerim Gattas-Asfura and Jessica Weaver, at the 2012 Biomedical Engineering Society Conference in Atlanta, GA.

CELL SUPPLY CENTER TO BE NAMED FOR FRED AND MABEL R. PARKS FOUNDATION The Trustees of the Fred and Mabel R. Parks Foundation have announced a $2 million commitment to establish the Fred and Mabel R. Parks Cell Supply Center at the DRI. The Center is charged with developing an infinite supply of insulin-producing cells to be housed in the “mini-organ” which will normalize blood sugar levels. Please look for the full story in the next issue of Focus. (Pictured: Foundation President Jim McClellan with a Cycle of Discovery award.)

A Message

from the Chairman Dear Friends, The holidays are a time to reflect upon the past year, give thanks for all of the wonderful people in our lives and set our sights on a new year full of achievement. This issue of DRIfocus encompasses all of these themes. We begin by expressing sincere gratitude to the Fred and Mabel R. Parks Foundation and its president Jim McClellan for their recent $2 million gift that will name the DRI’s cell supply center. This significant donation, together with gifts received from other generous donors, will help support one of the most exciting initiatives we’ve seen yet. As you read in our cover story and other articles within, our DRI scientists are working collaboratively on the development of a mini organ to mimic the native pancreas. Building upon its progress in islet transplantation, the DRI is addressing the research challenges that remain. Our tissue and bioengineering teams are at the center of much of this effort with the development of new, biocompatible platforms to house and protect the insulin-producing cells. We are thrilled to be moving toward clinical testing of one of these platforms in the coming year and look forward to keeping you abreast of this pioneering work.

FOUNDATION STAFF NEWS

It took a dedicated effort to reach this point and we are grateful to the entire DRI team for their unyielding commitment to our mission. We are also deeply thankful to the many wonderful people within our DRI family – people like you and our other generous donors and volunteers, many of whom are pictured throughout this issue. Your involvement has made a huge difference in our ability to move research forward – and the progress we report here is a testament to that. On behalf of all of us at the Diabetes Research Institute and Foundation, thank you for your support of our work. With your involvement, we continue to make the significant strides that keep our belief in a cure alive. Wishing you a happy, healthy and prosperous holiday season and New Year. Sincerely,

Harold Doran Chairman of the Board 1

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1. Nicole Otto 2. Dena Kawecki 3. Douglas Ramirez 4. Jill Salter 5. Sarah Mehan

The Diabetes Research Institute Foundation is proud to welcome two new people to the team and announce the promotions of three staff members. Nicole Otto has been a vital member of the DRI Foundation staff since joining the organization in 2001 and was recently promoted to associate director of special events in the Florida office. She has overseen a number of successful events and has proven strengths in developing strong relationships with donors and committee members and creating opportunities for increased event support. Nicole is personally entrenched in the mission of the DRI since her fiance has type 1 diabetes, and she truly believes the DRI is the best hope for a cure. Dena Kawecki joined the Florida special events department as special events manager in August. Not only does she bring with her years of experience in development and special event planning, but she also has been specializing in the “diabetes world” for some time. She worked for the Juvenile Diabetes Research Foundation in the Hartford, CT, area and later for the Denver/Rocky Mountain Chapter. In both positions, she worked closely with committees and leadership to promote the organization. Douglas Ramirez joined the Northeast office as special events manager in July. He comes to the DRI Foundation with significant

event experience with New York City nonprofit organizations. Most recently, he was the special events manager for the Greater New York affiliate of Susan G. Komen for the Cure. He has cultivated and secured donations from individuals and corporate sponsors, as well as solicited in-kind donations. Douglas also has been responsible for event logistics, production and marketing plans for a variety of events. Jill Salter was recently promoted to the position of development manager in the Northeast office. With a gifted eye for detail, she has served as a strong asset to the Foundation since 2004. Jill has previous nonprofit experience with UJA-Federation (United Jewish Appeal), and also spent time in the corporate sector, working at Arthur Young, R.R. Bowker, General Instrument, and Lane Bryant. Sarah Mehan joined the Florida office in March of 2011 and was recently promoted to special events coordinator. She’s very excited to get more involved with all the families from the event committees since her heart lies in working with children. She started her career as a pediatric nurse at Joe DiMaggio Children’s Hospital and also served as a nanny. Through her experiences, she has seen what a diabetes diagnosis can do to a family and is now dedicated to the DRI’s cure-focused mission.

NEW MEMBERS TO SERVE ON NATIONAL AND REGIONAL BOARDS 1

The Diabetes Research Institute Foundation is pleased to announce the appointment of three new directors to the National Board and one new member to the Long Island Regional Board. John C. Doscas has been on Wall Street for over 30 years. He is managing partner of Chartwell Trading, a proprietary global arbitrage firm. Previously, John was co-founder and president of Hudson Bay Capital. He has advised numerous hedge funds on the financial markets and has served on many financial industry panels and committees. He also invests and is active in the commercial real estate market. John and his wife, Anne, have supported the DRIF’s Long Island regional events since 1999, but when their eldest son, Christopher, was diagnosed with type 1 diabetes at age 20 in 2009, they began a worldwide search to identify the organization that was best equipped to find a cure. It’s no surprise they ended right back at the DRI. The family, including Christopher’s siblings Michelle and Peter, toured the DRI’s state-of-the-art facility earlier this year, and John served as the honoree for the Crystal Ball. Sean McGarvey, president of the Building and Construction Trades Department (BCTD) of the AFL-CIO, started his career with the International Union of Painters and Allied Trades (IUPAT) in 1981 as an apprentice glazier with Glazier’s Local 252 in Philadelphia, PA. Since then, he has held a number of union positions and worked through the ranks until he was elected secretary-treasurer of the BCTD in 2005. On April 16, 2012, following the untimely passing of former President Mark H. Ayers, Sean was elected to the office of president of the BCTD. He serves on several boards and as a trustee on numerous labor management committees. The unprecedented partnership between the DRIF and the BCTD spans more than two decades. The Foundation’s largest contributor, the BCTD committed to funding – and building – the DRI facility in Miami years ago. Today, Sean promises that union support will continue and strengthen until the DRI finds the cure for the millions of children and adults affected by diabetes. Sean currently resides in Huntingtown, MD, and has two lovely daughters, Kerri Ann and Kelsey Marie. He also has a close family member with type 1 diabetes. David Sherr is the founder and managing partner of One William Street Capital Management, L.P. (OWS) and is responsible for overseeing all aspects of the firm’s day-to-day activities. He is also the head of the firm’s Investment and Management Committee and

a member of the Risk and Valuation Committees. Prior to this, he was a managing director of Lehman Brothers, where he served in a senior leadership role. David has 25 years of experience in the investing and origination businesses, fixed income markets and managing global trading. Like the Doscas family, David and his wife, Holly, searched the world over for a cure-focused facility after their eldest child, Matthew, was diagnosed in 2005 at age 6. After taking a tour of the DRI, they committed themselves to the cause, as David said assuredly, “It might take time, but we will find a cure.” Since then he joined the Northeast Regional Board, and the family has been involved with numerous fundraising events. The Sherrs also have three daughters, Emily, Hannah and Julia.

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Joining the Long Island Regional Board, Wendy Waller is a longtime supporter of the DRI and is involved with a variety of real estate entities in Glen Cove. Prior to that, she worked in fashion and retail management. Wendy is a generous, hard- working and extremely motivated member of the DRI family. Her commitment to a cure stems from love for her niece, Dara Kris-Melnick, who was diagnosed with type 1 more than 20 years ago. Wendy has been an integral member of the Crystal Ball committee since 2009. She chairs the gala auction prize committee, and because of her tireless efforts, the prizes have increased in number, value and dollars raised. She has co-chaired Champions for Charity, Wedding Veil Walk for A Cure and Fall Into Fashion, where she also was honored as the first recipient of the Humanitarian Award in 2011. Everyone who meets Wendy is impressed by her energy, determination, enthusiasm and results, and the Foundation is thrilled to have her join the regional board.

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1. John Doscas, 2. Sean McGarvey, 3. David Sherr, 4. Wendy Waller

YEAR END TAX PLANNING NOTE

With all of the uncertainty about the changes ahead, year-end tax planning is challenging this year. Actions taken between now and year-end may be more important than ever. One consideration for many individuals in the estate tax arena is making use of all or part of the $5,120,000 temporary gifting allowance which may never exist again. If you are in a position to use this historically high gifting exemption, dollars that might have otherwise gone to pay taxes could now be freed up to support the DRI. Moreover, with the possibility of the estate tax rate rising up to 55%, including the DRI in your estate plan is more valuable than ever. Your investment in the DRI will change the lives of millions in the future. 3 |

MAKING A DIFFERENCE WITH THE GIFT THAT

BENEFITS THE DRI AND YOU

Did you know that...

...you can arrange for year-round income using charitable gift annuities? ...there are no fees or costs involved in setting up a charitable gift annuity (CGA)? ...the assets you contribute to fund your CGA will be managed by professionals? Many of our most generous donors have carefully planned for the future utilizing charitable gift annuities to further the mission of the Diabetes Research Institute and Foundation. Throughout her life, Shirley Harris has made a difference helping others. For future generations, her extraordinary vision and generosity continues with charitable planning and philanthropy beyond her lifetime. Because she has always felt compelled to support research toward a cure, she recently announced her intention to leave the DRI Foundation one of the largest bequests in its history. Her benevolence also includes establishing charitable gift annuities for the benefit of the Diabetes Research Institute. Shirley wanted to make things a little easier for a couple of her friends, so she has funded charitable gift annuities to benefit them. Shirley explained, “I received the tax benefits and am able to enjoy helping my friends now – while I am alive, knowing that my gift will continue to provide for them for the remainder of their lives.” She has also planned for CGAs to be set up via her estate to benefit others who are close to her. “It gives me joy to know that l can help people I care about long after I’m gone.” Charitable gift annuities benefit the DRI and the donor. The charitable gift annuity provides an income stream for life. The amount of the payments that you will receive are based on your age and the amount of the gift annuity. Ultimately, the remainder of the annuity will benefit the work of the Diabetes Research Institute. There are different types of charitable gift annuities to suit specific needs. A flexible deferred CGA can be set up as a means of supplementing retirement income. The donor can select a starting date at some point in the future and a portion of the annuity payments are tax-free. Robert Pearlman and Dr. Camillo Ricordi gratefully acknowledged Shirley Harris for the legacy she has created to benefit the Diabetes Research Institute and Foundation through estate planning.

A special type of deferred CGA can also be arranged for grandparents who want to help with college expenses for their grandchildren. For example, a grandparent can name their grandchild as the annuitant of a CGA, with life payments to begin at age 18. The annuity payments would be converted to four annual installments, with the student receiving large payments during the college years. Key benefits of a CGA include the following: •

The donor receives a charitable tax deduction in the year that the gift is made, or can opt to carry over a portion of the deduction over five years;

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Avoidance of capital-gain tax on the initial transfer of appreciated assets to the CGA;

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Potential transfer-tax (gift and estate) savings;

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Avoidance of probate administrative costs.

For Shirley Harris, all of the potential benefits of the Charitable Gift Annuity are “the icing on the cake” for her ultimate goal. “Knowing that I am helping to find a cure for diabetes and make it a disease of the past is what’s most fulfilling for me,” she said. For a more personalized illustration on how a charitable gift annuity can benefit the DRI and you, please contact Jill Shapiro Miller, vice president of gift planning, at (800) 321-3437.

IMMEDIATE-PAYMENT ANNUITY RATES (SINGLE LIFE)

AGE 65 70 75 80 85 90+

RATE / %

4.4 5.1 5.8 6.8 7.8 9.0

ACT NOW TO BE PART OF THE CURE AND MAXIMIZE THE IMPACT OF YOUR CHARITABLE DOLLARS The future of charitable deductions is uncertain. So if you are thinking about giving to support the cure, please consider making your gift to the DRI Foundation before year-end while you can still receive the maximum tax benefit.

VARIETY IS THE SPICE OF LIFE DIABETES DIPLOMATS USE EVERYTHING FROM EXERCISE TO AN ELEPHANT TO RAISE FUNDS FOR THE DRI!

Even though the Diabetes Diplomats program lays out a tried and true plan for organizing a school assembly and walk, some of the DRI Foundation’s heroes choose to embark upon projects of their own creations. One ingenious 22-year-old even involved an elephant in his fundraising plan! It all began in Miami, FL, in February at the Love and Hope Ball, where a colorful, four-foot-tall elephant caught the eye of Sam Billetdeaux. He and his family had spent the previous day touring the DRI’s labs, where, for the first time in his life, Sam found hope for a cure for the disease he has lived with since he was 8 years old – type 1 diabetes. Full of conviction and eager to support the DRI’s work while at the gala, Sam placed a generous bid on the impressive creation of artist Marcie Ziv as it stood among other fabulous silent auction prizes, and won. Although this elephant didn’t need food and water, it did need a name. Thus, a unique fundraiser was born! Sam decided to ask the diabetes community for help, first calling upon participants of the Children with Diabetes (CWD) "Friends for Life" conference, which took place July 3-8. People who attend the event, after all, are much like family to him since his mom, Laura Billetdeaux, organized the first conference in 2000 and is CWD's vice president of education and programs. The elephant was displayed at the DRI Foundation's booth, where Sam asked for a $5 donation from anyone who wanted to submit a name. Those who chose to make a $25 donation were entered into the grand prize drawing for a five-night stay at a Disney Deluxe Villa! After the conference concluded, Laura and her husband, Neal, traveled with the prized pachyderm from Orlando to New York City, where Sam would determine his pet’s moniker and announce the grand prize winner via video. During the trek, the contest was opened up to the public and the diabetes online community (DOC) tagged along on the zany journey by following a special blog “written by” the elephant himself! Sam chose the name Beta Cellephant, which was submitted by the Jarcho Family, who won a $100 Walgreens gift card for their creativity. The Hrinkevich Family won the stay at Disney World, and the DRI took the cake, receiving more than $1,400 in donations. While Sam’s fundraiser revolved around a zoo animal, Meghan Henneberger was focused on Zumba! The North Shore High School student thought this popular combination of dance and exercise was the perfect way to support the work that she hopes will lead to a cure. Both she and her younger brother, Kevin, have type 1 diabetes. In conjunction with the school’s Key Club, Meghan organized a Zumbathon in Glen Head, NY, on April 27, raising nearly

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1. Sam Billetdeaux with Beta Cellephant at the CWD Conference this past summer, 2. North Shore High School Principal Albert Cousins and Meghan Henneberger, the student who organized a Zumbathon, present a check to DRIF LI Regional Director Anthony E. Childs.

$2,500. Because of the success, popularity and mission of this first-time effort, the North Shore High School Key Club is planning to make the Zumbathon an annual event. Also an annual affair is the online effort of Jesse Nagel, who was one of the DRIF’s very first Diabetes Diplomats. With his personal fundraising page, Jesse has raised more than $6,500 for the DRI! Another "Humaniteen" from New York, singer Jenna Rose Swerdlow decided to donate the proceeds from downloads of her most recently-released single, Life is a Party, to the DRI, for two days in August. Jenna Rose also performed at DRIF’s Carnival for a Cure event last year. She is eager to support the cause in honor of her grandmother, who has diabetes. In Florida, Jonny Greenwald has been serving as a Diabetes Diplomat for years in honor of his younger sister, Lexi, who has type 1 diabetes. But this year he took it a step further, creating a space online for siblings of PWDs to converse and share fundraising project successes. If you’re doing a project in honor of your sibling with diabetes, then join The End Zone, a team of siblings dedicated to tackling diabetes at Facebook.com/TheEndZone4Diabetes! Don’t Do Nothing! Learn more about Diabetes Diplomats and how you can become one at DiabetesResearch.org/DiabetesDiplomats!

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FOUNDATION DONORS RECOGNIZED

Awards from the DRI Foundation’s Cycle of Discovery series were presented to donors who recently made major gifts. The award program corresponds with the Foundation’s cumulative giving designations. Awards were presented individually and at various events, including a lovely dinner at the Garden City Hotel in Long Island and a donor appreciation reception for those involved with the Empire Ball at The Durst Organization in New York City. 1

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PERPETUATION AWARD: Nancy Smalkas of Caesars Entertainment with President Sean McGarvey (left) of the Building and Construction Trades Department and DRIF’s Tom Karlya (1). TRANSLATION AWARD: Marty Granowitz (2).

EXPLORATION AWARD: Anne and John Doscas (3), Darren Levine of Platinum Maintenance Services Corp. (4), Barry Rosen of CH Robinson with former Miami Dolphin quarterback Don Strock (5), Dennis Sherry of CBRE, Inc., accepting Hypothesis and Exploration (6). 17

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HYPOTHESIS AWARD: Mick Carnevale of ThyssenKrupp Elevator America (7), Jim Migliore of William Macklowe Company (8), Alex Samilenko of Fred Geller Electrical, Inc. (9), Michele Schnellbacher and Eric Schnellbacher of Schnellbacher-Sendon Group, LLC, accepting Query and Hypothesis (10), Rachel and Bruce Siegel (11). QUERY AWARD: Kelly Bacon of TPG Architecture, LLP (12), John Bennardo of Legacy Builders/Developers Corporation (13), Elizabeth and Rob Frisoni (14), Ed Meirowitz and Jarrett Huddleston of Consulting Associates of New York, Inc. (15), Doreen and Andrew Peykar (16), Joe Slater accepting on behalf of the Slater Family with Strock (17), Frank Zappala of Crossland Mechanical, Inc. (18).

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DONOR LEVEL

AWARD

Visionaries Chairman’s Council Leadership Council Governors’ Society Distinguished Humanitarians Grand Founders Founders Benefactors

$10,000,000+ $5,000,000+ $1,000,000+ $500,000+

Innovation Validation Perpetuation Translation

$250,000+ $100,000+ $50,000+ $25,000+

Realization Exploration Hypothesis Query

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RECOGNIZING JAKE FISCHER

For our Focus newsletter, we are always looking to feature articles that will inspire others, lift spirits and remind us all to never give up hope. Jake Fischer's story does just that. He recently directed gifts in excess of $37,000 to the Diabetes Research Institute. While the amount in itself is enough to make our scientists smile, what’s most amazing is that Jake is 13 years old! He asked the guests invited to his bar mitzvah to make a donation to the DRI in lieu of gifts. His mother, Jill Fischer, said, “Jake is very happy to support diabetes research. This cause is so important to our family.” His aunt, Kim Dickstein, who serves as a Northeast Regional Board member, added, “It is our family’s pleasure to support an organization that seeks to cure diabetes, especially one as special as the DRI. This disease creeps through our family tree at an insidious rate – three with type 1, three with type 2 – affecting the last five generations.” The money will help purchase the Leica CM3050S Cryostat, a precision instrument used to cut extremely thin slices of tissue for microscopic examination. It is a key piece of equipment for all research projects underway at the Institute. We offer special thanks to Jake and to everyone who contributed in his honor.

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FROM EVENT SPONSOR TO MAJOR DONOR: JIM SENSALE IS PROUD TO BE IN THE DRI FAMILY Nothing means more to Jim Sensale than trust and family. You can hear it in his voice, feel it in his hand shake, and see it as you walk through the office of the company he built 35 years ago. President of Aviation Instrument Services, Jim works alongside his two sons, Brad and Mike, his brother, Felix, and his nephew, Floyd. He even named his boat Family Affair, and he’s been married to his sweetheart, Miriam, for 48 years. Jim is, as they say, one of the good guys, and people know it just by the way he lives his life. So, when Jim put his trust in the Diabetes Research Institute, it was nothing short of an honor.

Even after the event was discontinued in the early 90s, Jim said, “It won’t stop me from donating and supporting the DRI, and we’ve been donors ever since.” More than two decades later, the Sensales are part of the Foundation’s Governors’ Society, which includes donors of $500,000 or more, and Jim serves on the Florida Regional Board of Directors. “For me, the DRI is family. Barbara and Shelly put their heart and soul into this organization and turned their dream into something special,” he said. “Just like in business, you deal with people you trust, and I feel the DRI is the best place you can invest your money.” “Jim is an extraordinary person. He gives unselfishly with his heart and soul, and the only thing he wants in return is to know that he’s helping to find a cure for diabetes. And he truly is,” said Barbara. “I wish I could clone him!” Jim and Miriam and their sons took a tour of the Institute, where they walked through the laboratories, spoke with the scientists and learned firsthand about the DRI’s research toward a biological cure.

“Jim swooped in and saved the day years ago for an event where the lead sponsor dropped out near the final hour,” said Barbara Singer, who is director of special projects at the Diabetes Research Institute Foundation and, along with her husband, Shelly, is one of the founding families of the organization.

“The scientists are extremely dedicated, hardworking people that care very much about what they do. When you see the facility and meet the scientists in person, it’s very obvious,” said Jim. “Miriam and I wanted to bring the boys on the tour so they could see where our money was going and know exactly why I will continue to donate. Plus, we wanted them to know why it’s important to be a giver.”

Jim was already involved with the event at a lower sponsor level and wanted to support the cause since Floyd has been living with type 1 diabetes since he was a teenager.

Jim continued, “I donate to other charities, but I’m not involved with them on the same level as I am with the DRI. I only wish I had the time to do more.”

“I was happy to step in as the lead sponsor of the Catch a Cure fishing tournament and continued for a few years,” explained Jim.

DRI AND FOUNDATION REMEMBER DR. GEORGE F. CAHILL, JR. The international diabetes community lost a legend with the passing of Dr. George F. Cahill, Jr., 85, in August. A world-renowned diabetes researcher, Dr. Cahill, who had served as research director of the Joslin Diabetes Center and the Howard Hughes Medical Institute, played a key role in the growth of the DRI in its early years as a member of its Scientific Advisory Board (SAB). Cahill was widely respected throughout the diabetes community and was introduced to the DRI by Dr. Albert Renold, a respected diabetes researcher from Switzerland and close friend of DRI Scientific Director Emeritus Dr. Daniel H. Mintz.

Cahill became a huge proponent of the DRI after learning more about its vision to cure diabetes and concept of uniting researchers from multiple disciplines under one roof. “Dr. Cahill felt that this was the way research should be conducted in the century ahead and then joined our SAB. He was a tremendous asset in directing us and guiding us in people to recruit to the Institute,” said Mintz. Cahill’s support and affiliation gave the DRI’s scientific program legitimacy at an important time in its history. “He had a reputation of being dedicated to excellence and people would trust what he would say,” added Mintz. “It was one of the most critical things that happened for our international credentials as a group that was serious about finding a cure for diabetes.” Dr. Cahill’s expansive knowledge on diabetes and insulin led to his being selected as an expert witness for the prosecution in both trials of Claus von Bulow in the 1980s.

UNDER THE MICROSCOPE Cherie Stabler, Ph.D., is excited.

with Cherie Stabler, Ph.D.

For years, she has focused on engineering a platform that can house and help protect transplanted islet cells – a major step toward the DRI’s goal of building a “mini organ” that mimics the native pancreas. Now, with the development of a “scaffold” – a sponge-like substance, slightly larger than a quarter – her research is moving us closer to that goal. The DRI expects to begin testing of the scaffold in clinical trials next year. But that’s not all she’s excited about. As you’ll read below, there are many other promising developments in the research pipeline that will help create an optimal environment for the new islet cells. Throughout this interview, Dr. Stabler, director of tissue engineering, emphasized how the ability to work with researchers from a variety of disciplines – a unique aspect of the DRI – is critical for reaching a biological cure for diabetes. “It really is unparalleled,” she said of her ability to collaborate with a multidisciplinary team. “I go other places and they say, ‘I cannot believe you have this kind of access.’” And that access allows progress at a faster rate. “I’m excited to see all of the things we have in the pipeline, to see all these pieces that will fit very well together, that will be highly complementary and will truly improve what we have now in terms of current clinical islet transplantation.” For an extended version of this interview, please go to DiabetesResearch.org/UTM-Stabler Q. Can you update us on your research using scaffolds? A. We’ve done extensive studies in several preclinical models and have obtained encouraging results with them. We’ve achieved promising insulin function in all of the recipients, and we’ve achieved insulin independence in many of them. Q. What’s the next step? A. So far, we’ve achieved these promising results using scaffolds made by hand. Now we’re working on fabricating the scaffolds in a reproducible manner, so we can scale up. When we have this perfected manufacturing protocol, which is what we’re in the midst of right now, we will perform definitive pre-clinical model studies. Along with this are many requirements from the FDA that we have to complete and finalize – all of the regulatory paperwork, quality assurance, and other issues required for clinical trials – for use in people with diabetes. Q. How close are you to using these scaffolds in clinical trials? A. We anticipate about a three-month process for the manufacturing and regulatory issues, three-to-six months for pre-clinical trials, and then we’ll work with the FDA for approval. So, our plan is to be able to transplant these by 2013.

Q. What material is used to make up the scaffold? A. We’ve been focusing on PDMS, also known as silicone. It’s been used for medical implants for decades. It has a great clinical profile already. It’s highly biocompatible and stable. So, we knew in terms of trying to translate these to the clinic that we had an easier regulatory pathway. We have procured clinical-grade silicone that’s an appropriate source for long-term use. We feel like this is the best material for us to move forward with, in the strategy of having a retrievable device long term, so it’s something we can go in and take out if we need to, as well as the safety associated with that. In the selection of the material, we really wanted a platform that could incorporate all of the additional components needed to create an even more optimal implant, such as the ability to deliver drugs and oxygengenerating materials, and this is very amenable to those kinds of things. Q. Where will the scaffolds be placed in the body? A. We will continue to focus on the omental pouch (in the abdomen) as the site of transplant. In our studies, led by Dr. Norma Kenyon (DRI senior scientist and Martin Kleiman Professor of Surgery, Medicine, Microbiology and Immunology), we’ve looked

at several different sites. I think we’ve seen the most promise and most flexibility with the omental pouch. We can transplant the size implant that we want. There’s wonderful vascularization and healthy remodeling. We’ve seen positive responses to implants at this site. So, I think we’ll continue to use this as our site moving forward. Q. So far, islets have been transplanted into the liver. Why the new site? A. There are many challenges with the liver. One is that you’re putting islets in direct contact with the bloodstream, and the bloodstream contains inflammatory cells and inflammatory reactions. So, you are exposing islets to a lot of inflammation when you transplant into the bloodstream. Also, many drugs are processed in the liver and the byproducts of the drug metabolism can be toxic to the islets. Another challenge is that we lack control over being able to define where the islet cells go because they get scattered throughout the liver. When we are able to place islets into a defined, confined site, we will have control of that local micro-environment. And that really opens up many doors of being able to incorporate novel strategies to promote islet cell viability, islet function and protection, among others. Story continues on page 10

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THE DRI AROUND

DIABETES RESEARCH INSTITUTE AWARDED $ 4.6M TO TAKE ISLET TRANSPLANTATION TO NEXT LEVEL JDRF and The Leona M. and Harry B. Helmsley Charitable Trust provide three-year grant

DRI Scientific Director Dr. Camillo Ricordi and his team have received a $4.6 million grant to make islet cell transplantation, an experimental procedure that has improved blood glucose control and the quality of life of some with type 1 diabetes, available to more patients. The three-year grant from the JDRF and The Leona M. and Harry B. Helmsley Charitable Trust will help the DRI team define a new and safer implant site for islet cells, increase the survival and function of the transplanted islets and eliminate the need for life-long systemic immunosuppression drugs. Dr. Ricordi serves as the grant’s principal investigator together with Dr. Luca Inverardi, DRI deputy director, who is co-principal investigator. “This is a critically important and timely support that will allow our team to remain focused on the path to a biologic cure for diabetes,” Ricordi said. “The overall goal is to use a multipronged approach to address and resolve all of the outstanding issues in islet transplantation and move the field to the next level of success.” Performed at the Diabetes Research Institute since the 1980s, successful islet cell transplants give patients with type 1 diabetes the ability to naturally produce their own insulin, and lead healthier, more independent lives. However, only a subset of patients benefit from the procedure because of the problems associated with the need for chronic immunosuppression drugs to assure graft survival, and the low survival rate of islets when transplanted into the currently used transplant site, the liver. In fact, islets are particularly susceptible to hypoxia (low levels of oxygen) and inflammation in the immediate post-transplant period. In their grant proposal, “Development of an Extrahepatic Site for Beta Cell Replacement without Continuous Immunosuppression,” Dr. Ricordi and his team propose to address those issues, first by using the omental pouch, a fold in the lining of the abdominal cavity, as a safer and more easily accessible transplant site. They also plan to promote islet survival in the early post-transplant period by using bioactive scaffolds, providing the islets a milieu that can be adapted to their demands, and to promote immunoprotection with a novel encapsulation technology. The DRI has already obtained encouraging preliminary data, generated through the support of the Diabetes Research Institute Foundation, the JDRF and the Helmsley Trust, and on the unique assets at the DRI, where scientists with complementary expertise have long worked in concert to address the multidisciplinary challenges that still make islet transplantation an experimental procedure offered only to a small subset of patients.

UNDER THE MICROSCOPE So, while there’s been very promising results in islet transplantation in the liver — illustrating the great promise of islet transplantation — we believe we can make a safer and better islet cell transplant by taking it out of the liver and implanting it in a definable, retrievable site.

DRI Scientists Publish New Books DRI Scientific Director Dr. Camillo Ricordi has co-authored a book, La Fine Del Diabete (The End of Diabetes), which offers a perspective on the international research model required to cure diabetes and other devastating diseases. Dr. Ricordi has donated all compensation and royalties from the book to the Fondazione Italiana Diabetes, which has been turning over the entirety of its donations to the DRI Foundation. An English translation of the book will follow in 2013. Dr. Peter Buchwald, director of drug discovery at the DRI and assistant professor in the department of Molecular and Cellular Pharmacology at the University of Miami, has co-authored with Dr. Nicholas Boder from the University of Florida, a new book, Retrometabolic Drug Design and Targeting, that provides researchers in drug discovery and design with complete guidance on how to use approaches to develop safe, effective, and targeted drug therapies. Dr. Buchwald, who served in the pharmaceutical industry for many years, directs the DRI’s efforts aimed at developing safer and more effective drugs for cell replacement therapies.

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Q. If the scaffold serves as kind of a “base platform” to house the islet cells, then what else is needed to create an optimal environment for the insulin-producing cells? A. The big thing for islets is oxygen. Because islets are kind of “super athletes” in the cell world, and their oxygen consumption rates are so much higher, we

really need to meet their oxygen demands. Blood vessels deliver that oxygen, so we can put agents into the scaffold that will promote the growth of blood vessels, or vascularization, as quickly as possible in a very organized structure. But it’s still going to take time for all those

GENEROUS GIFT SUPPORTS POST-DOCTORAL RESEARCH FELLOW A gift from a generous DRI Foundation donor will help support one of our young scientists, Carmen Fotino, Ph.D., who began a post-doctoral fellowship at the DRI a few years ago under the guidance of Dr. Antonello Pileggi, director of pre-clinical cell processing and translational models. She comes to the Institute from the University of Pisa in Italy, where she earned her undergraduate degree in science and Ph.D. in endocrinology and metabolic sciences. Dr. Fotino is part of the team that conducts the first steps in the translational research process, where all projects at the DRI begin, by testing new strategies for immunomodulation, novel devices and materials, alternative sites for transplantation, and stem cell technologies, as well as other cure-focused areas. She is responsible for the many facets of cell cultures and isolation and the analysis and maintenance of various cell types, among other experiments in conjunction with Dr. Pileggi. A co-author of numerous scientific articles and abstracts that have been published in leading peer-reviewed journals, Dr. Fotino has a personal passion for ensuring that the DRI discovers a cure. “My father has been fighting diabetes for more than 40 years. Through my family’s experience with the difficulties of managing daily life, I have developed a great interest in diabetes research,” she said. “I always had a strong desire to join a research institution committed to curing diabetes, and I considered myself very lucky when the opportunity arose to join Dr. Pileggi’s lab as a post-doctoral fellow. I am grateful for this wonderful gift that will help to advance my education and support my career as a research scientist.”

POST-DOCTORAL FELLOWS TAKE FIRST AND SECOND PLACE IN ANNUAL COMPETITION Congratulations are in order for two post-doctoral fellows, Joana Almaca, Ph.D., and Danusa Menegaz, Ph.D., who took first and second place, respectively, for their research projects entered into the University of Miami’s Annual Post-doctoral Fellows Research Day competition. Dr. Almaca, received the top award among 46 entries across the UM Miller School of Medicine for her work in determining how insulin is released from beta cells and will help in developing new therapeutic targets to improve insulin secretion. She is a post-doc in the lab of Dr. Per-Olof Berggren, head of cell biology and signal transduction and the Mary Lou Held Visiting Scientist at the DRI. Dr. Menegaz is studying factors that hamper regular insulin secretion and lead to insulin resistance in patients. She works together with Dr. Almaca and Dr. Midhat Abdulreda, research assistant professor of surgery, in Dr. Berggren’s lab on numerous experiments. Postdoctoral fellows play an integral role at the DRI and throughout the medical school in supporting their colleagues. The purpose of this annual event was to celebrate and appreciate their important research contributions to many projects. Drs. Almaca and Menegaz certainly made all of us at the DRI proud!

structures to develop. So we have developed an oxygen-generating material that has the capacity to supplement oxygen during that interim time period. We’ve demonstrated that this oxygen-generating material has tremendous benefits for islets in preventing hypoxia-induced necrosis, which is cell death induced by low oxygen. Our vision for this

oxygen-generating material is really to serve as a bridge between when we implant the cells to when the islets are fully vascularized.

One avenue we’re exploring is local drug delivery, and the scaffold is very amenable to local drug delivery.

Q. How is the issue of rejection and immunosuppression being addressed? A. We want to minimize, as much as possible, the need for systemic immunosuppression.

Read the continuing UTM interview at DiabetesResearch.org/UTM-Stabler.

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INSULIN PUMP THERAPY:

KELLIE’S TOP TIPS FOR GETTING STARTED

Currently, insulin can be administered via syringe, insulin pen or insulin pump. It’s a personal choice; however, pumps are increasingly becoming more popular with people with type 1 diabetes and insulinrequiring type 2. There are a few key tips for optimizing your success… Are you a pump candidate? • Who wants the pump? You, your family or health care provider? Except for a young child, it should be the person with diabetes making the decision. • Are you technically capable? If you can text on a cell phone, the answer is yes! • Are you monitoring your blood sugar levels at least four times a day? This is essential with pump therapy given use with rapid acting insulin. • Can you carb count accurately? This is also essential given insulin dosage is based on the carb information provided.

Explore all your pump options. There are currently six insulin pumps available in the U.S. (T-Slim, Omnipod, Animas Ping, Medtronic, Spirit and DANA Diabecare II) and this is going to change rapidly over the next few years. Be sure you review all your pump options to ensure you make the best decision for you and your life. Essentially all pumps come with smart features and you are generally basing your choice on the different “bells and whistles” available with each pump. The DRI conducts a class called Introduction to Pumps, which provides a full overview of technologies available (DiabetesResearch.org/ insulin-pump-therapy). Obtain insurance verification. Know if you are likely to have any out-of-pocket expenses with pump therapy implementation. Each insulin pump company has representatives who assist with this verification process. There should be no surprises!

Get optimal pump training! Most problems associated with pump therapy arise from improper implementation due to a lack of optimal training. There are four phases to pump therapy training: Phase 1: Technical Training – Learn how to push the buttons on your pump, program settings and undertake a complete site insertion and site change. Phase 2: Pump Management – Learn how to manage your pump in various life situations. It is essential you receive this information at the time you start insulin pump therapy – not weeks, months or years later. Phase 3: Follow-up – Ensure you contact your health care team within the first week on an insulin pump to notify them how you are progressing. Your health care team will notify you whether this should be in the form of a telephone call, email or visit, with the latter essential if you are experiencing any challenges. Also, arrange a formal follow-up session with a member of your health care team within three to four weeks for full evaluation and pump download to identify any early opportunities for improved management. Phase 4: Advanced Pump Features – All pumps come with advanced features to assist people with diabetes to handle different life situations that arise. These advanced features pertain largely to exercise, carbohydrate coverage, sick days or monthly cycles and are unfortunately grossly underutilized or unknown by many people using insulin pump therapy. As I tell my patients, “Why have a Ferrari if you are going to drive it like my Jeep!” So get the best from your insulin pump technology by knowing its full capabilities.

PROVIDED BY: KELLIE RODRIGUEZ, MSN, CDE, CPT DRI’S DIRECTOR OF EDUCATION SERVICES

LET ME COUNT THE WAYS TO GIVE

Your generous support is so critical and so appreciated! There are so many ways that you can help the Diabetes Research Institute find a cure. Below is a short list of easy ways to give, and we have additional ideas posted on our website. Go to: DiabetesResearch.org/Ways-to-Give Special Occasions From birthdays and bar mitzvahs to weddings and graduations, people are making their special occasions even more meaningful by adding a charitable component. Couples are choosing to make a contribution

in honor of their guests rather than traditional favors. Kids are accepting donations in lieu of presents. The ideas are endless, and we couldn’t be more thankful! If you need an idea of what verbiage to use in your invitations, please contact us at 1-800-321-3437 or [email protected].

Join the PEP Squad…any time, anywhere! Whether your family is new to the diabetes world or you’re just entering a different season of life with diabetes, the PEP Squad (Parents Empowering Parents) can give you the support you need to stay balanced and positive. The group that started with about 12 moms and two therapists in a conference room at the DRI Foundation office in Florida, and later New York City and Long Island, has grown exponentially online (Facebook.com/groups/PEPsquadDRI). With more than 1,000 members and growing, the PEP Squad group page on Facebook is a place where diabetes parents can bounce ideas off one another, share daily stories and struggles, complain, vent, or mentor and shed new light. Someone is there, at any time of day – even in the wee hours after that 3 a.m. BG check. “The power of having a vehicle – other parents with skills – as sounding boards to decipher what is going on improves the way we and the people we listen to handle the repetitive challenges of diabetes,” said DRI’s Wendy Satin Rapaport, a clinical psychologist who helped create the program in 2006. “Sometimes by helping someone else, we can better see how our own responses might require some updating. The process of venting, sharing strategies, and then mentoring is a gift that keeps giving.” Some of the topics discussed include insurance issues, nighttime testing, travel tips, facing fears, holiday hints, bragging rights (about the brave kids!), tools, teens and tantrums. Whatever the issue may be, there are usually comments or suggestions. However, please remember that everyone is different, and you should check with your health care professionals before making any changes. The DRI Foundation takes the opinions of this group seriously. When one member posted a concern about the group being “open,” it was immediately changed to a “closed” group to ensure that only members are able to read posts. There is also valuable information for download or print. PEP Squad members are telling their friends about it, and it has become an ever-expanding circle of parents who find comfort in “talking” to each other. You can tell by some of the feedback: Krystal: I have "liked" this page for quite a while now...but when you

decided to make it a closed group, I set it to notify my newsfeed every time there is a PEP post....you guys are precious and so encouraging. So even after 6 years of living with a type 1 son....thank you so much for being there! And I hope to be there for you too. :) Cheryl: I was looking for a place where I could talk. My daughter, now 17 months old, was diagnosed with type 1 at 10 months old, and there are a lot of times when I feel alone!!!! Caralynne: I have found this group to be so helpful and supportive! Shantelle: This group is just a bunch of fabulous people. We all share the same common enemy. People in this group truly understand what you’re going through. Jamie: I'm sorry you have to be here, but please know you’re surrounded by a bunch of wonderful parents who totally get it. Ask anything, or just vent, anytime. We are all in this together. One mom wrote, “I've looked high and low for local support groups and have had no luck. I would love to find another type 1 child for my son to connect with locally. Not sure if anyone would feel comfortable posting their city/state but it may be a good way to find other type 1 families close to you.” Almost instantly, she received dozens of responses, and other parents were able to find connections, too. A physical support group may not always be possible, and since time is a scarce commodity with families today, online support groups such as the PEP Squad are an invaluable resource. Sometimes all you need is to know you’re not alone. Often all it takes it is one word, and this one sums up the PEP Squad most accurately… Lea Anne: Hugs.

Keep in mind that you can also send an e-card to a loved one with a donation to commemorate holidays and other special occasions. Check out our adorable snowman made with the universal blue circle symbol for diabetes. Find more at: DiabetesResearch.org/ecards Keep Calm and Cure Diabetes The ever-changing “Keep Calm and Carry On” saying has made its debut to the DRI family! Aptly altered to Keep Calm and Cure Diabetes, the T-shirts are available for purchase on our website. It’s perfect for

everyday casual wear, or to sport at walkathons or while doing other Diabetes Diplomat projects. The cost is $15 per shirt. Get one for the whole family at: DiabetesResearch.org/Keep-Calm-and-Cure-Diabetes 13 |

The Tachers organized Team Jace, which was the top family fundraising team at last year’s walk.

FAMILY TEAMS WALK WITH WALGREENS AND THE DRI We love Walgreens! And it’s not just because it’s our favorite neighborhood stop for prescriptions, photos and a whole lot more. It’s not simply that the company is a trusted partner of the DRI Foundation that, in the past three years, has helped raise in excess of $750,000 for our cure-focused work – good reasons, yes…but that’s not it. It’s about people. We love the people at Walgreens who have personally joined with us to fight diabetes with everything they’ve got. It’s Roy Ripak, market vice president, whose hands-on leadership approach has ignited a movement throughout stores in the state of Florida and beyond. It’s Georgia Lehoczky, market pharmacy director, whose passion and enthusiasm incites action in their upper management team. It’s store managers like Victor Lehoczky, Tom Lehoczky, Clint Smethurst, Dan Espinosa and Sal Sastre, plus service clerks, pharmacy staff and photo techs, who mirror that same dedication and drive. These are the people who organize the Walk with Walgreens Family Fun Day & Health Fair in support of the DRI – even though they work long hours running a cadre of 24-hour stores; plus they have personal lives, families, hobbies and dreams. They devote long hours, afterhours, signing on sponsors, getting vendors, securing entertainment, locating venues, and so on; and they do it for one reason. Just like you – they want a cure for diabetes. And just like us, they’re “in it to end it,” as DRIF Vice President Tom Karlya would say!

ever! They’re going so big that the parks that have hosted the events in the past just won’t cut it. The new location is Sun Life Stadium in Miami Gardens, home of the Miami Dolphins – so cool! Think balloons, face-painting, family activities, heart-thumping music, free giveaways, refreshments, health booths and more… plus the camaraderie of being part of a community-wide effort. For those a little farther north, there will be a simultaneous event in Port St. Lucie at Tradition Square. Do you love Walgreens as much as we do? Then, get involved! Organize a family or office team and join us at the walk. Last year, families like Tacher, Ferris, Greenwald and Schechter helped raise thousands of dollars. They wore group T-shirts to set themselves apart from the crowd, held up signs and pictures of the person with diabetes that they were walking for, and made this Walgreensorganized event a “DRI Family” event. If you’re not there, you’re missing! Can we count on you? Let us know by emailing Nicole Otto at [email protected]. “We are so excited about this year's Walk with Walgreens,” said Jenn Tacher, who has organized Team Jace for the past three years in honor of her son who has type 1 diabetes. “DRI scientists are doing everything to find a cure for Jace. So, I’m doing my part by helping to raise money so they have the resources they need to make that happen sooner.  I encourage everyone to come out to the walk to support this effort.”

What’s most exciting is that the third annual event, which is slated for Saturday, April 20, 2013, is going to be bigger and better than

A SUPERSTORM BRINGS OUT SUPER HEROES As millions continue to struggle in the aftermath of Hurricane Sandy and the nor’easter that followed, we commend the efforts of so many courageous people who have risen as heroes in the wake of this tragedy. Worthy of sharing is the story of Jenna Katzman MacLaga, a nurse who was working at a New York hospital on the night of the hurricane. She personally helped to evacuate her 23 patients from the 12th floor – with no elevators and no power! And, Jenna has type 1 diabetes. Windows were breaking all around her, and the hospital was virtually surrounded by water from the East River. We can only imagine how the stress and activity was affecting her blood sugar! Thankfully, she is fine, but it was a harrowing experience for Jenna and many others. She and her co-workers are to be commended for their professionalism and heroism under the most extreme conditions. Do you know someone else with diabetes whose Herculean efforts helped those in need during the storm? Share your story on our Facebook at: Facebook.com/DiabetesResearch.org

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AFL-CIO’S BUILDING AND CONSTRUCTION

TRADES DEPARTMENT REAFFIRMS COMMITMENT TO A CURE

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More than a quarter of a century ago, the AFL-CIO’s Building and Construction Trades Department (BCTD) committed to funding – and building – the Diabetes Research Institute facility. Since then, union members have raised tens of millions of dollars to provide ongoing support of the DRI’s quest for a cure through their annual Labor of Love weekend and nationwide DAD’s Day events. Carrying the same mission to a new location in 2012, Labor of Love was held this year in Baltimore, MD, May 19 - 21. The weekend began with the Annual Bricklayers’ and Allied Craftworkers’ Softball Slam, which was played in Camden Yards at Oriole Park, thanks to the generosity of event host Peter Angelos. The ever-popular Labor of Love Golf Tournament took place at Baltimore Country Club. Awards dinners and receptions were enjoyed by all, but the highlight for many was Labor Night at the Ballpark, where BCTD President Sean McGarvey threw out the first pitch at the Orioles vs. Red Sox game. The fun-filled gathering attracted 400 BCTD members, exceeding $600,000 in proceeds, more than ever before!

1. Maryland Governor Martin O’Malley (center) welcomes Labor of Love, represented by DRI Foundation Vice President Tom Karlya (left) and BCTD President Sean McGarvey, to Baltimore., 2. DRI Scientific Director Camillo Ricordi, M.D., shares his gratitude with McGarvey in front of the plaque at the DRI that says, “Built by the hearts and hands of America’s workers, whose generosity and craftsmanship knows no bounds.”

McGarvey, who was elected to serve as BCTD president after the passing of Mark Ayers, visited the Institute in June. Scientific Director Camillo Ricordi, M.D., and other researchers explained the studies underway in their labs and how these projects intertwine to create a roadmap for a biological cure for diabetes. And McGarvey, who had previously promised to keep alive the partnership between the DRI and the BCTD, resolutely reaffirmed his organization’s commitment to the cause. As word of DAD’s Day fundraisers rolled in, so did proof of the group’s relentless support. Mostly held in the days and weeks surrounding Father’s Day, Dollars Against Diabetes campaigns across the nation involved golf outings, softball tournaments, bowling matches, street corner collections, motorcycle poker runs, and more. The DRI and Foundation extend sincere thanks to the members of the BCTD and their family and friends who volunteer time and efforts every year to support the work underway at the DRI.

L-R: Derek Pasch and Joe LaPadula of Martino Auto Concepts; Councilman Tony Jimenez; Nassau County Legislator and DRIF board member Delia DeRiggi-Whitton; DRIF LI regional board Chairman Allan L. Pashcow; Mayor Ralph V. Suozzi; Councilman Timothy Tenke, Assemblyman Charles Lavine, Councilman Nick Deleo, DRIF LI Regional Director Tony Childs; and Joe Manfredo.

MOTOR MAVENS, BORN TO BE

AT GOLD COAST CONCOURS/BIMMERSTOCK On Sunday, September 9, more than 700 exotics and fine vehicles from the world’s most desired marquees lined the streets of downtown Glen Cove, NY. Presented by Martino Auto Concepts/MAC Auto Couture and SONY, the 4th Annual Gold Coast Concours/Bimmerstock provided a dream come true not only for thousands of spectators, but also for event creators Joe LaPadula and Derek Pasch, who announced that the day’s proceeds reached a record $91,000 for the DRI! "From a single conversation, this event has grown into one of the largest automobile shows in the area. This event attracts car enthusiasts and vendors from around the country, and with our Diabetes Research Institute relationship we know that everything we do helps fund the effort to find a cure,” said LaPadula. While the day showcased Ferraris, Rolls Royces, Porsches, Mercedes and customized BMWs, in addition to several very limited edition cars, such as a Lola, an Enzo Ferrari and several Ferrari Challenge racers, cars weren’t the sole attraction. The day also featured great food, live music from The School of Rock, and a number of fabulous sweepstakes prizes.

DRI Foundation Long Island regional board Chairman Allan L. Pashcow expressed thanks to LaPadula and Pasch, both from Martino Auto Concepts, SONY Corporation, and other event sponsors and committee members. He then went on to acknowledge Glen Cove Mayor Ralph Suozzi and other local elected officials. Michael Puntillo was also acknowledged for donating the use of the village square. Special recognition was given to DRIF National Board member Bruce Waller, as well as DRIF Long Island Regional Board member and Nassau County Legislator Delia DeRiggi-Whitton, for all of their help organizing the event. Dara Kris-Melnick was presented with a citation for her ongoing support of the DRI. She then spoke to the crowd about her battle with type 1 diabetes, thanking everyone in attendance for supporting the DRI’s quest for a cure. Sponsors included: Martino Auto Concepts/MAC Auto Couture; SONY Corporation; 3M; The Bristal; Competition BMW; Ecybermedia; Lomotion; PPG Single Source; Rallye BMW; Anchor Audi; BMW of Bayside; Habberstad BMW; Hassel BMW & Mini; VOS Motorsports; Laffey Associates and Leone Homes. 15 |

EVENTS

Don Strock Diabetes Golf Classic

On May 9, former Miami Dolphins quarterback Don Strock (2nd from right) led 150 golfers onto the courses at Miccosukee Golf and Country Club in Miami, FL, for his 29th annual golf classic. Presented by Miami Seaquarium, represented by Tom Smith (far right), the Don Strock Diabetes Classic once again featured a day spent hitting the links, followed by a cocktail reception and dinner program. As always, Strock led the exciting live auction after recognizing Tournament Chairman Bruce Fishbein (2nd from left) and his hardworking committee, composed mainly of members of the produce industry. Proceeds surpassed $125,000, thanks to such patrons as Coca-Cola, which served as Dinner and Goody Bag Sponsor and was represented by Giovanna Garcia-Pons (far left.) DRI Foundation COO Deborah Chodrow (center) extended gratitude to all in attendance, including a host of celebrity participants.

D.R.E.a.M.S. in the city The seventh annual D.R.E.a.M.S. in the city (Diabetes, Research, Elegance and Modern Sophistication) raised $650,000 thanks to Co-chairpersons Samantha Shanken Baker, Bonnie Inserra and Risa Pulver, as well as 500 generous guests. After the featured research project was introduced by the Late Show with David Letterman’s Alan Kalter, Tina Santi Flaherty made a matching gift challenge that was exceeded by the group’s generosity. Even 13-year-old Jake Cohen redirected his bar mitzvah gifts to the DRI! The fabulous evening honored Bernd G. Heinz (right), president and CEO of The Heinz Group, LLC, and Art Smith (left), executive chef and owner of Joanne Trattoria, Table Fifty-Two, and other acclaimed restaurants. Pictured with them (center) at 583 Park Avenue in New York, NY, on May 17 is DRI Scientific Director Camillo Ricordi, M.D.

Young Society of Love and Hope Haute Tea Deemed South Florida’s social event of spring, Haute Tea was held by the Young Society of Love and Hope in collaboration with Neiman Marcus Bal Harbour at The St. Regis Bal Harbour Resort on May 18. The tea-inspired luncheon and fashion presentation began with a champagne reception for the 125 ladies in attendance, each elegantly adorned with her finest hat and heels. Event Chair Jillian Posner, dressed in a matching pink Arturo Rios hat and Valentino heels with a striped black and white dress designed by Miriam de la Cruz, showed gratitude to her committee (pictured), as well as the vendors who helped create the beautiful event, and media sponsors Miami Magazine and SocialMiami.com.

Brenda Novak’s Online Auction for Diabetes Research Famed author Brenda Novak (pictured) and her supporters have broken another record with her Online Auction for Diabetes Research . Held at BrendaNovak.com throughout the month of May, the auction has raised a cumulative total of $1.6 million – $306,000 in 2012! Held in honor of Brenda’s son, Thad, 15, who was diagnosed with type 1 diabetes at age 5, the eighth annual fundraiser attracted more than 6,000 bidders from across the country and from around the world, eclipsing last year’s record-setting number of 5,000. More than 1,000 authors, including Steve Berry, Barry Eisler, Eloisa James, Nicholas Sparks, Diana Gabaldon and Janet Evonovich, contributed their time, expertise or items – another personal best for Novak who reaches out to her literary colleagues for donations each year. The top five items with the highest winning bids included a Celine Dion Meet & Greet, a literary evaluation by author Daniela Rapp of St. Martin’s Press, two African safaris and tickets to artist Ceelo Green’s Las Vegas Show.

Buy In for a Cure Novices and experienced card players alike enjoyed the Second Annual Buy In for a Cure Texas Hold'em Tournament on June 14. More than 100 guests joined in the action, helping to raise $40,000. Trophies and prizes were presented to winners, such as those pictured. Guests also enjoyed fabulous food, cigars, fine wines and spirits at the beautiful Garden City Hotel in Long Island, NY.

Mastering Your Diabetes Designed specifically for anyone on insulin, pump users or injection-based users, Mastering Your Diabetes is an educational program held at the Diabetes Research Institute four times per year. The June 18-22 session was a special one, geared for PWDs aged 1-18. Eight kids and teens, accompanied by their parents, came from as far away as Iowa, Philadelphia and the Bahamas, to learn how to optimize their independence. Participants met daily with a physician, nurse and dietician for a blood glucose and insulin management review. They practiced counting carbs in the food lab and making exercise fun in the wellness center. The group members also expressed their individual thoughts and feeling about diabetes through art and were privy to a social worker’s helpful tips for living better with diabetes. Students finished out the five days of interactive learning by competing in an exciting “Who Wants to be MYD Grandmaster” diabetes trivia game.

Ron Darling Celebrity Golf Classic Hosted by the Ron Darling Foundation for the fourth year, the Ron Darling Celebrity Golf Classic attracted more than 100 golfers and several celebrities to Pine Hollow Country Club in East Norwich, NY, on July 9. After a day on the course, participants enjoyed a dinner and awards ceremony. Pictured with Ron Darling (right) and Fireman Ed, NY Jets superfan (left) receiving the Ron Darling Cup is the winning team from FTI Consulting. Darling serves on the DRIF’s national board of directors and is dedicated to helping the DRI eradicate type 1 diabetes, which his youngest son was diagnosed with at age 11.

E.R.A.S.E. Diabetes Longtime friends Erin Berg Hager and Gary Edward Bailey (pictured) celebrated their milestone birthdays with a Baroque Bash at The CocoPlum in Coral Gables, FL. In lieu of gifts, they asked their friends and family members to make donations to the E.R.A.S.E. Diabetes Fund for the DRI. Subsequently, the party held on July 28 raised in excess of $100,000! The festivities included cocktails, dinner, dancing and entertainment by cirque performers. The Berg Family has been supporting the DRI for more than two decades, ever since Erin was diagnosed with type 1 diabetes as a teen. Now, a mom with a family of her own, she carries on the philanthropic mission of E.R.A.S.E. – Erin’s Race Against the Stress and Effects of Diabetes.

Rod Gilbert DRI Golf Classic Held at the beautiful Pine Hollow Country Club in East Norwich, NY, on August 6, this annual fundraising tournament bearing the name of New York Ranger hockey legend Rod Gilbert (center) was once again directed by Bob Zuckerman (far left) and Eric Reeps (2nd from right.) This year the committee was pleased to honor Continental Home Loans, Inc., Executive Vice President Sam Baretta (2nd from left.) Also pictured is Anthony Vitale (far right). After a day of birdies and bogies, 150 golfers enjoyed a delicious dinner, a fabulous array of desserts, and an incredible live auction. The popular event is held each year in memory of Helaine Shari White and Anthony John Vitale. 17 |

EVENTS

Spin for a Cure at Sky On August 19, Sky Athletic Club hosted an indoor cycling event in the town of Rockville Centre on Long Island. All of the proceeds from this one-hour spin class benefited the DRI. In addition, Sky Athletic Club generously provided use of their bikes and four dynamic instructors, who motivated the class to ride like the wind! Special thanks are extended to The Pellizzi Family and friends (pictured.)

Phil Peterson’s Key West Poker Run Phil Peterson’s 40th Anniversary Key West Poker Run kicked off for thousands of bikers on September 14 with a gorgeous ride through the Florida Keys. The destination was Duval Street in Key West, FL, and the event’s traditional moniker as South Florida’s biggest motorcycle party weekend of the year remained intact. The affair was even more festive for Miguel Castellanos of Orlando, who won a new Harley Davidson 883 Sportster Iron by holding the best hand in the final Texas Hold’em game. Pictured thanking the crowd are (l-r) DRI Foundation Associate Director of Special Events Nicole Otto, Dirk Peterson and Drew Peterson.

Pig Roast The Otten Family of East Islip, NY, once again organized their popular Pig Roast on Saturday, September 22. More than 200 guests enjoyed the festivities of this old-fashioned barbeque, which was held under big, white tents in the Otten’s back yard. Pictured are (l-r) DRI Foundation VP Tom Karlya, Michael, Gigi and Nicholas Otten, plus Anthony Childs, DRI Foundation Long Island regional director.

Cocktails for a CURE Leslie Hsu and Greg Besner hosted their first Cocktails for a CURE fundraiser in New York City at the Hudson Terrace nightclub on the evening of September 15. Featuring wine and spirits, fabulous food, music and dancing, the event was organized in honor of their 10-year-old daughter, Willa, who was diagnosed with type 1 diabetes shortly after her 4th birthday (pictured with DRI's Dr. Luca Inverardi). The Besner Family was honored that more than 200 friends and family joined them in their fight for a cure at the event. Willa sold bracelets to raise funds on her own, and she and Leslie visited the DRI a few weeks later to deliver a donation from Willa’s Wish Foundation for $30,000. According to Greg, next year will be “an even bigger event and an even bigger donation!”

Brindisi Coalition for a Cure Louis Brindisi, an attorney in Utica, NY, held his second "Brindisi Coaltion for a Cure" event on Saturday, September 15, at the historic Fort Schuyler Club in Utica. His youngest son, Louis Thomas Brindisi, 14, developed type 1 diabetes at the age of 11. He vowed to help the DRI move toward a cure, and raising in excess of $50,000 with this year’s event, he’s keeping his promise. To date he has raised almost $150,000. Pictured with Brindisi (center) are: another of his sons, NY State Assemblyman Anthony Brindisi; Utica Mayor Rob Palmeri; DRI Foundation VP Tom Karlya; and Senator Joe Griffo.

The Donaldson Organization Golf Outing Ranked one of the top courses in the U.S. and the world by Golf magazine, Winged Foot Golf Club played host to over 200 golfers on a crisp sunny day at The Donaldson Organization Golf Outing on October 1 in Mamaroneck, NY. Benefiting the DRI for the second year and raising more than $500,000, the event honored Robert Gorton of Gorton & Partners, LLC and Peter Marchetto of Tishman Construction. It was chaired by D. Robert (Bob) Donaldson (left), whose son, Douglas R. Donaldson (right), serves on DRIF’s Long Island regional board, and whose grandson, Matthew, was diagnosed a few years ago with type 1 diabetes.

Fashion & Beauty Week Mixer Hosted by Jack Panico, founder of Fashion & Beauty Week, and president and CEO of Panico Salon and Spas, the Fashion & Beauty Week mixer and Spring/Summer Designer Preview Party was held at Club Vibe in Riverdale, NJ, on October 4. The affair generated excitement for the upcoming Fashion & Beauty Week, to be held in the spring of 2013. Last year, it raised more than $47,000 for the DRI while showcasing the state of New Jersey with its high-fashion people, places and style. Pictured are models in Sue Wong dresses.

Empire Ball Kick-Off The New York Real Estate Division of the DRI kicked off the 2012 season for their signature event, the Empire Ball, at The Durst Organization in New York, NY, on October 18. Members of the group’s board of governors and committees, plus event sponsors and honorees, all of whom are connected to the real estate industry, were presented with Cycle of Discovery Awards and recognized for their generosity. To be held on the memorable date of 12-12-12, the Empire Ball is expected to once again raise in excess of $1 million for the DRI. Pictured are Empire Ball Co-chairs Peter DiCapua (far left) and Charlie Rizzo (far right) with (l-r) Alex Samilenko, James J. Migliore, Dennis Sherry, Eric Schnellbacher, and Mick Carnevale. 19 |

DRIfocus

Non-Profit Org. US Postage PAID Diabetes Research Institute Foundation

Diabetes Research Institute Foundation National Office 200 South Park Road Suite 100 Hollywood, FL 33021 address service requested

CALENDAR

For information on the events or to make reservations, visit DiabetesResearch.org or call one of the DRI Foundation offices listed below.

Champions for Charity December 2012 / LONG ISLAND An annual holiday shopping benefit designed to raise funds for over 80 not-for-profit organizations, a percentage of sales will be donated to the DRI when using a Champions for Charity Card throughout the month. Shop, shop!

Love and Hope Ball February 2, 2013 / FLORIDA The 39th Annual Love and Hope Ball will be held at the Westin Diplomat Resort and Spa. This extraordinary black-tie gala will feature a grand cocktail reception, a sumptuous dinner, dancing and live entertainment.

Pleasures of the Palate January 13, 2013 / FLORIDA This spectacular, four-course gourmet dinner, designed and prepared by legendary Chef Norman Van Aken, will be paired with specially-selected wines for each course. The night will also feature a live and silent auction of rare, fine wines, spectacular travel experiences and more.

A Gift of Love…A Gift of Hope February 11, 2013 / FLORIDA To be held at The Polo Club in Boca Raton, the 14th annual event, organized by the Palm Beach Auxiliary, will feature a delightful lunch, a unique boutique filled with fashionable items, a raffle and an afternoon of card-playing.

It’s a Charity Thing! January 30, 2013 / NEW YORK To be held at Gotham Comedy Club, stand-up comic Alyse Kenny brings you some of the area’s funniest comedians for a night of big laughs for a great cause.

three D March 1, 2013 / FLORIDA Come dine, drink and discover with us at this exciting new event to be held at the Rubell Family Collection in Miami's Design District. Enjoy creative gourmet cuisine, jaw-dropping live art performances and more.

Carnival for a Cure March 10, 2013 / NEW YORK The seventh annual event will be held at the Metropolitan Pavilion in Manhattan and feature live entertainment, delicious food, games for tots and teens, super prizes and a fabulous silent auction. Kids Party for a Cure March 10, 2013 / LONG ISLAND This afternoon of fun for the entire family at Dave and Buster’s will feature video games, inflatables, face painting and more, plus a buffet dinner for the whole family and a silent auction. American Fine Wine Competition Gala April 4, 2013 / FLORIDA This sixth annual affair will be held at the Boca Raton Resort and Club. Guests will taste more than 600 of the finest wines made in the U.S. while enjoying world class food, entertainment, auctions and ambience.

DRIfocus

is a publication of the Diabetes Research Institute Foundation. Fall 2012 / Volume 40 / Issue 1

Marketing & Communications Dept. Lori Weintraub, APR Lauren Schreier Natasha Norris Laurie Cummings

Contributors Gary Kleiman Jill Salter Aimee Siegel-Harris Mitra Zehtab, M.D. Stacy Zolotin

Photography Carl Cox Photography Marc S. Levine Photography Magique Studios Lynn Nathanson Pete Pellizzi Teekay Mitchell Zachs Design Franz Franc Design Group Inc.

Walk with Walgreens Family Fun Day & Health Fair April 20, 2013 / FLORIDA See page 14 for details. Cooking for a Cure April 2013 / LONG ISLAND To be held at Page One Restaurant in Glen Cove, this tasteful event includes an auction, sweepstakes drawing and live entertainment. The Crystal Ball May 4, 2013 / LONG ISLAND This annual black-tie gala always sparkles with a fabulous cocktail reception, gourmet dinner, auctions, dancing and more at the beautiful Garden City Hotel. D.R.E.a.M.S. in the city May 7, 2013 / NEW YORK Featuring specialty cocktails, a seated dinner, live and silent auctions and dancing, this eighth annual event, will be hosted by the Late Show's Alan Kalter at The Pierre Hotel.

The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. Miller School of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure those now living with diabetes. To obtain additional information or request copies of DRIfocus, please call (800) 321-3437 or e-mail [email protected], or visit DiabetesResearch.org. DIABETES RESEARCH INSTITUTE FOUNDATION National Office 200 South Park Road, Suite 100 Hollywood, FL 33021 Phone: (954) 964-4040 Fax: (954) 964-7036 [email protected]

Northeast Regional Office 381 Park Avenue South, Suite 1118 New York, NY 10016 Phone: (212) 888-2217 Fax: (212) 888-2219 [email protected]

Long Island Regional Office 410 Jericho Turnpike, Suite 201 Jericho, NY 11753 Phone: (516) 822-1700 Fax: (516) 822-3570 [email protected]