Beckman Coulter Product Milestones 1930s 1935

Model E pH Meter - First Beckman pH Meter (sold approximately 350,000 Models E, F, and G over next 50 years)

1936

Model F pH Meter

1937 1937

Model G pH Meter (sold approximately 27,800) Model M pH Meter

1940s 1940

Helipot Precision Potentiometer

1941

DU Quartz Spectrophotometer (sold approximately 34,000)

1942 1942

Model R Industrial pH Meter IR-1 Infrared Spectrophotometer

1943 1943 1943

Model P Oxygen Analyzer – first commercial oxygen analyzer Model D2 Oxygen Analyzer RXG Micromicroammeter

1945

Model H Electrophoresis System. Tiselius-cell system was first to separate immunoglobulins from other serum proteins

1946

IR-2 Infrared Sectrophotometer

1947 1947 1947

Models 789 and 790 Decimal Counting Units Model E Ultracentrifuge Flame Attachment for DU Spectrophotometer

1948

Model B Spectrophotometer

1949

MX-8 Radioactivity Detector

1950s 1950 1950 1950 1950

Model L Preparative Ultracentrifuge GP (general purpose) pH Sensitive Electrode EPUT Events per Unit Time Meter Model K Automatic Titrator

1951

Model V Micromicroameter

1952 1952

Model 102 Dosimeter EASE Analog computer

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1953 1953 1953

Model R Electrophoresis System. First commercially manufactured system using Durrum cell paper medium; produced five zone electrophoresis pattern. Model W Industrial pH Meter Model H Electrophoresis Diffusion Instrument

1954 1954

DK-1 Spectrophotometer Model III Data System

1955 1955 1955 1955 1955 1955

LB Nondispersive IR Analyzers Ferristor Direct Reading Flame Photometer Model R Paper Electrophoresis System DK-2 Spectrophotometer Model 28 Auto Exhaust Analyzer

1956 1956 1956 1956 1956

Pocket pH Meter IR-4 Infrared Spectrophotometer CP continuous Flow Electrophoresis System Cermet Potentiometer GC-1 Laboratory Gas Chromatograph

1957 1957 1957

PGC 120A Process Gas Chromatograph 112 Transistorized Data Processing System IR-5 Infrared Spectrophotometer

1958 1958 1958 1958 1958 1958

Mark III Submarine Atmospheric Analyzer Model 210 Data Processing System Automated Amino Acid Analyzer IR-7 Infrafed Spectrophotometer First Mobile Air Monitoring Laboratory Trimming Potentiometer

1959

Megachrom Preparative-Scale Gas Chromatograph

1960s 1960 1960 1960

Model DB Spectrophotometer (sold approximately 24,000) Microfuge Centrifuge (high capacity miniature centrifuge built specifically for clinical lab samples) Ultramicro Analytical System

1961 1961

Pycnometer Dynograph Recorder and EEGs

1962

Medical Gas Analyzer

1963 1963

LS-1 Liquid Scintillation Spectrometer First Titanium Ultracentrifuge Rotor

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1964 1964 1964 1964 1964

LS100C Liquid Scintillation DU-2 Spectrophotometer Zonal Ultracentrifuge IR-11 and IR-12 Infrared Spectrophotometers Microzone Electrophoresis System

1965 1965

Atomic Absorption Analyzer LS-2000 Series Liquid Scintillation Sytems

1967 1967 1967

Hybrid Microcircuits Vital Signs Monitor Model R-110 Microzone Densitometer

1968 1968

Blood Chemistry Monitor DSA-560 Discrete Sample Analyzer Company’s entry into clinical chemistry analyzers; processed over 100 samples per hour for 25 chemistries

1969

Glucose Analyzer First of a kind dedicated instrument using rate methodology for glucose analyses; STAT system, uses a 10 mL sample; directly measures blood sugar in 3 minutes Infrared Exhaust Emission Analyzer Protein Sequencer L3-40 Preparative Ultracentrifuge LS-16 Liquid Scintillation System

1969 1969 1969 1969

1970s 1970 1970 1970 1970

Diagnostic Reagents First group of dry enzyme reagents sold in bulk for use on many clinical instruments. ACTA V Spectrophotometer J-21 High Speed Centrifuge Model 117 Automatic Amino Acid Analyzer

1971 1971 1971 1971 1971

Microzone Digital integrator KLiNa Flame System Protein-Peptide Synthesizer Elutriator Rotor Uric Acid Accessory Kit for Glucose Analyzer

1972

Blood Urea Nitrogen Analyzer

1973 1973 1973 1973 1973 1973 1973

System TR. First dedicated automated analyzer for clinical enzymes. Accutrace Electroencephalograph Biogamma Radioimmuno Analyzer Series 4200 Infrared Spectrophotometers pHASAR-I pH Meter (liquid crystal display readout) RIAphast HTSH – first kit on the market L5 Preparative Ultracentrifuge

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1973 1973 1973 1973 1973 1973 1973

Model 121M Microcolumn Amino Acid Analyzer Century SS-1 pH Meter Model 4500 Digital pH Meter Liquid Crystal Display modules for electronic wristwatches Model 590 Vehicle Exhaust Analyzer Model 6700 Process Gas Chromatograph Acculab Infrared Spectrophotometer

1974 1974 1974 1974 1974

Model B Microfuge Tabletop Centrifuge System 1 Glucose/Blood Urea Nitrogen Analyzer ACTA M UV Spectrophotometer Model MB Series RIA Data Reduction System Model R-112 Scanning Densitometer

1975 1975 1975 1975 1975 1975

Airfuge Ultracentrifuge Series3100 Liquid Scintillation Systems Chloride/CO2 Analyzer CDS-100 Computing Densitometer Biogamma II System Metabolic Measurement Cart

1976 1976 1976 1976

Model 3500-4500 Digital pH Meters Model J6 and TJ-6 Centrifuges Metabolic Measurement Cart Gamma 8000 System

1977 1977 1977 1977

PHASE 1 RIA Sample-Handling System LS-7000 Liquid Scintillation System Creatinine Analyzer. First instrument designed for clean, color free creatinine analyses; STAT system uses a 25 m. sample. Immunochemistry Analyzer

1978 1978 1978 1978 1978 1978 1978 1978

Glucose and BUN Analyzers - Second generation Microlab 600 computing Infrared Spectrophotometer System ASTRA 4 and ASTRA 8 Automated Stat Routine Analyzer Systems TRACE III Clinical Spectrophotometer System LS-7000 microprocessor-based liquid scintillation counter J-6B Centrifuge L8 programmable Preparative Ultracentrifuge Liquid STAT Enzymatic Reagents (pre-diluted, stabilized reagents)

1979 1979 1979

Microtox Acute Water Toxicity Monitor MV 8000 Process Control System Glucose, BUN and Creatinine 2 Analyzers

1980s 1980 1980

Auto ICS Electrolyte 2 Analyzer

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1981 1981 1981 1981 1981 1981 1981

System E4A Model 42 Clinical Spectrophotometer Paragon Electrophoresis System Laboratory Management System Microfuge 11 and 12 Centrifuges DU-7 UV/Visible Spectrophotometer pHI Series pH Meters

1982 1982

Lumadex FSI Fetal Lung Maturity Test System 6300 High Performance Amino Acid Analyzer

1983 1983 1983 1983

Accuspin Digital Centrifuge FTIR Fourier Transform Infrared Spectrophotometer System 1 DNA Synthesizer CALS Computer Automated Laboratory System

1984 1984 1984 1984 1984 1984 1984

TL-100 Bench Top Ultracentrifuge DU-50 UV/Vis Series Spectrophotometers Model 170 Radioisotope Detector MicroGenie database of entire sequence library of nucleic acids Appraise computerized densitometer Laboratory Management Systems TL 100 Tabletop Preparative Ultracentrifuge

1985 1985 1985 1985

System 7300 DU Analyzer Series AA (1,2,3 & 4) Amino Acid Analysis Systems L-7 Ultracentrifuge Future II Calomel Electrode

1986 1986 1986 1986 1986 1986 1986

Biomek 1000 Automated Laboratory Workstation Prep 350 Gradient Liquid Chromatography System Array Protein System Microfuge E Miniature Tabletop Centrifuge Ultrapore C8 HPLC Column LS 1701 Benchtop Liquid Scintillation Counter 96 Well Plates

1987 1987 1987 1987 1987 1987 1987 1987 1987 1987 1987

Synchron CX3 Clinical Analyzer Paragon SPE Serum Protein Electrophoresis Kit System Gold series of PersonalT Chromatographs Model 171 Radioisotope Detector DU Series 60 and 70 UV/Visible Spectrophotometers System Gold for various Analyzers Model L7-65 Ultracentrifuge Appraise Junior Densitometer GP Series Centrifuges INTERLINK System for Synchron Systems Lablyte 800, 810, 820 and 830 Electrolyte Analyzers

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1988 1988 1988 1988 1988 1988 1988

Biomek SL Robotic Arm LS 5000 Series Liquid Scintillation Counters Synchron CX4 Clinical Analyzer Synchron CX5 Clinical analyzer pHI 32, 34 and 50 pH Meters 338 Gradient HPLC System DU 68 spectrophotometer

1989 1989 1989 1989 1989 1989

System 6300 Amino Acid Analyzer Synchron EL-ISE Electrolyte System L and XL Optima Series Ultracentrifuges P/ACE System 2000 for Capillary Electrophoresis LS 6000 Series Liquid Scintillation Counters Synchron CXL Clinical System

1990s 1990 1990 1990 1990 1990

Therapeutic Drug Monitoring (TDM) Assays for Synchron CX Systems DU Series 7000 Diode Array Spectrophotometers J-6 Series Centrifuges GS-6 Series Centrifuges GENELINE for DNA mapping

1991 1991 1991 1991 1991 1991 1991 1991 1991 1991

Array 360 System XL-A Analytical Ultracentrifuge Synchron CX7 Clinical System Synchron ASX Spinchron Centrifuges Array 360 CE Appraise Paragon Electrophoresis System Tabletop OPTIMA Ultracentrifuge J2 Series High Speed Centrifuges P/ACE System 2100 and 2050

1992 1992 1992 1992 1992

Oligo 1000 DNA Synthesizer L7-80 Ultracentrifuge Porton LF3000 Protein Sequencer P/ACE 2100 System for CE/MS Analysis DU Series 600 Spectrophotometer

1993 1993 1993 1993 1993 1993 1993 1993

Synchron CX5CE Clinical Chemistry Analyzer J6 Series Centrifuges: J6-HC, J6-MC and J6-MI LS 6500 Value/Scintillation System GS-15 Series Multipurpose Microcentrifuge J2-HC Centrifuge P/ACE 5000 Capillary Electrophoresis (CE) systems Avanti 30 Tabletop Centrifuge Paragon CZE™ 2000 Capillary Electrophoresis System

1994 1994

Biomek 2000 Laboratory Automation Workstation HPLC System Gold Series

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1995 1995 1995 1995

Avanti J-25 High Performance Centrifuge System Oligo 1000M DNC Synthesizer Optima XL-100 Ultracentrifuge Synchron CX Delta Clinical Systems Series

1996 1996 1996 1996 1996 1996

phi 200, 300 and 720 Series pH Meters Optima SX-A and XL-I Series Ultracentrifuges BioSys 500 and 2000 Protein Purification Workstations Avanti J-301 High Performance Centrifuge Biomek 2000 Laboratory Automation Workstation combined with ORCA Linear Track Robot System Microfuge R and Microfuge Lite

1997 1997 1997

P/ACE System MDQ Avanti Tandem J-20 Series High Performance Centrifuges ACCESS Immunoassay System

1998 1998

CEQ 2000 DNA Analysis System Optima MAX Ultracentrifuge – First to surpass one million g of force

1999 1999 1999 1999

CEQ 2000 DNA Analysis System - Performs fully automated DNA sequencing COULTER® AcT diff 2 Hematology Analyzer COULTER® HmX Hematology Hybritech® free PSA – First FDA-approved test for fPSA

2000s 2000 2000 2000 2000 2000

Biomek® FX Liquid Handling Workstation CEQ™ 2000XL DNA Analysis System Coulter® Gen•S™ Cell Hematology COULTER Ac•T 5diff™ CP Hematology Analyzer Avanti J-20 XP High Performance Centrifuge

2001

Span-8 and 384-well Pipetting Options for the Biomek® FX Laboratory Automation Workstation SYNCHRON CX® PRO Series of Analyzers SYNCHRON LX®20 PRO Clinical System with Closed-tube Sampling COULTER Ac•T 5diff™ CP Hematology System with Closed-tube Cap Piercing Access®2 Immunoassay System COULTER® LH 755 Hematology Workcell 1536-well Pipetting Option for the Biomek® FX Laboratory Automation Workstation and SAGIAN™ Core System

2001 2001 2001 2001 2001 2001

2002 2002 2002 2002 2002 2002

Cytomics FC 500 System, a Dual-laser, Five-color Flow Cytometer CEQ® 8000 Genetic Analysis System Avanti® J-E Centrifuge Vi-CELL™ Cell Viability Analyzer Optima™ L-XP Ultracentrifuge System SYNCHRON LX®i 725 Clinical System

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2003 2003 2003 2003 2003 2003 2003

ProteomeLab™ Initiative Allegra™ X-22 Series Benchtop Centrifuges UniCel™ DxI 800 Access® Immunoassay System ProteomeLab™ PF 2D CEQ™ 8800 Genetic Analysis System LH 1500 Series Hematology Automation System COULTER® LH 500 Hematology Analyzer

2004 2004 2004 2004 2004 2004 2004 2004 2004

GenomeLab™ SNPstream® Genotyping System. Biomek® 3000 and Biomek® NX Liquid Handling Workstations iTopia™ Epitope Discovery System ProteomeLab™ A2® Microarray System FC 500 CXP Flow Cytometry System Immage® 800 Serum Protein Analyzer Allegra® X-15R Refrigerated Benchtop Centrifuge Biomek® Assay Workstation Command Central

2005 2005 2005 2005 2005 2005

UniCel DxC 600 and DxC 800 Chemistry Analyzers Vidiera NsD Nucleic Sample Detection Platform Cell Lab Quanta™ Benchtop Flow Cytometry System Hemoccult ICT Genfind DNA Isolation Kit Vidiera NsP Nucleic Sample Preparation Platform

2006 2006 2006

UniCel DxC 600i Chemistry/immunoassay Work Cell Biomek FXP and NXP Laboratory Automation Workstations AutoMate 800 Sample processing Station

2007

UniCel® DxI 600

2008 2008 2008 2008 2008

Unicel® DxH 800 Unicel® DxC 680i work cell Unicel® DxC 860i work cell Unicel® DxC 880i work cell Unicel® DxC 660i work cell

2009 2009 2009

Unicel® DxH 800 HematoFlow work cell to automate manual differentials Gallios flow cytometer for research markets Navios flow cytometer for clinical markets

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