Antiretroviral therapy with indinavir 400 mg-ritonavir 100 mg twice daily containing regimen in HIV-1 infected women during pregnancy

AAC Accepts, published online ahead of print on 4 February 2008 Antimicrob. Agents Chemother. doi:10.1128/AAC.01301-07 Copyright © 2008, American Soci...
Author: Frederica Brown
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AAC Accepts, published online ahead of print on 4 February 2008 Antimicrob. Agents Chemother. doi:10.1128/AAC.01301-07 Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

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Antiretroviral therapy with indinavir 400 mg-ritonavir 100 mg twice daily containing regimen in HIV-1 infected women during pregnancy. 1# 2 3 1 Jade Ghosn* , Ines De Montgolfier , Chantal Cornélie , Stéphanie Dominguez , Claire 2 4 5 1 1 Pérot , Gilles Peytavin , Anne-Geneviève Marcelin , Michèle Pauchard , Zineb Ouagari , 6 1 5 1 Manuela Bonmarchand , Rachid Agher , Vincent Calvez , François Bricaire , Marc 3 1 Dommergues , Christine Katlama and Roland Tubiana1.

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1/ AP-HP, Departement of Infectious Diseases, Pitié-Salpétrière Hospital, Paris, 2/ AP-HP, Department of Neonatology, Pitié-Salpétrière Hospital, Paris 3/ AP-HP, Department of Gynecology and Obstetrics, Pitié-Salpétrière Hospital, Paris 4/ AP-HP, Department of Clinical Pharmacology, Bichat-Claude Bernard Hospital, Paris 5/ AP-HP, Department of Virology, Pitié-Salpétrière Hospital, Paris 6/ AP-HP, Department of Internal Medicine, Pitié-Salpétrière Hospital, Paris

*Corresponding author: Dr Jade GHOSN, MD, PhD Department of Infectious Diseases Pitie-Salpetriere Hospital 47 Boulevard de l’Hôpital 75013 Paris France Tel : 00 33 1 42 16 01 71 Email : [email protected]

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C A Abstract : 54 words Article: 1175 words

#: Present affiliation: Dr Jade GHOSN, MD, PhD, AP-HP, Departement of Internal Medicine and Infectious Diseases, Bicetre Hospital, Paris Sud University, Le Kremlin-Bicêtre, France.

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Abstract:

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We evaluated safety and efficacy of indinavir/ritonavir 400/100 mg bid based therapy in

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thirty-two HIV-infected women during pregnancy. Median indinavir trough concentration

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was 208 ng/mL during third trimester. At delivery, 26/28 women on indinavir/ritonavir had an

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HIV-RNA

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