170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

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Antimicrobial Bibliography Publications: Love, Melissa S., Millholland, Melanie G., Mishra, Satish, Kulkarni, Swapnil, Freeman, Katie B., Pan, Wenxi, Kavash, Robert W., Costanzo, Michael J., Jo, Hyunil, Daly, Thomas M., Williams, Dewight R., Kowalska, M. Anna, Bergman, Lawrence W., Poncz, Mortimer, DeGrado, William F., Sinnis, Photini, Scott, Richard W., Greenbaum, Doron C. “Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials.” Cell Host & Microbe, 12 (2012): 815-823. Som, Abhigyan, Navasa, Nicolas, Percher, Avital, Scott, R.W., Tew, Gregory N., Anguita, Juan. “Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and AntiInflammatory Activities.” American Society for Microbiology (2012): 1784-1791. Thaker, Hitesh D., Som, Abhigyan, Ayaz, Furkan, Lui, Dahui, Pan, Wenxi, Scott, R.W., Anguita, Juan, Tew, Gregory N. “Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses.” Journal of the American Chemical Society (2012): 11088-11091. Yan Li, Kushi N. Kumar, Jeffrey M. Dabkowski, Corrigan, Meagan, Scott, R.W., N sslein Klaus, Tew, Gregory N. “New Bactericidal Surgical Suture Coating.” Langmuir, 28 (2012): 12134−12139. Hua, J., Yamarthy, R., Felsenstein, S., Scott, R.W., Markowitz, K., and Diamond, G. “Activity of Antimicrobial Peptide Mimetics in the Oral Cavity: I. Activity against Biofilms of Candida Albicans.” Molecular Oral Microbiology 25 (2010): 418-425. Hua, J., Scott, R.W., and Diamond, G. “Activity of Antimicrobial Peptide Mimetics in the Oral Cavity: II. Activity against Periopathogenic Biofilms and Anti-inflammatory Activity.” Molecular Oral Microbiology, 25 (2010): 426-432. Tew, G., Scott, R.W., Klein, M., DeGrado, W. “De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications”. Accounts of Chemical Research (2010): 30-39. Choi, S., Isaacs, A., Clements, D., Liu, D., Kim, H., Scott, R., Winkler, J., Degrado, W.F. “De Novo Design and In Vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers.” PNAS, 106 (2009): 6968-6973. Colak, S., Nelson, C. F., Nüsslein, K., Tew, G. N. "Hydrophilic Modifications on an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity." Biomacromolecules, 10 (2009): 353-359. Madkour, A. E., Dabkowski, J. M., Nüsslein, K., Tew, G. N. "Fast Disinfecting Antimicrobial Surfaces," Langmuir, 25 (2009): 1060-1067.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Gabriel, G.J., Maegerlein, J. A., Nelson, C. F., Dabkowski, J. M., Eren, T., Nüsslein, K.,Tew, G.N. “Comparison of Facially Amphiphilic versus Segregated Monomers in the Design of Antibacterial Copolymers.” Chem. Eur. J., 15 (2009): 433-439. Scott, R.W., DeGrado, W.F., and Tew, G.N. “De novo designed synthetic mimics of antimicrobial peptides.” Current Opinions in Biotechnology, 19 (2008): 620-627. Yang, L., Gordon, V.D., Trinkle, D.R., Schmidt, N.W., Davis, M.A., DeVries, Som, A., Cronan, Jr. J.E., Tew, G.N., Wong, G.C.L. “Mechanism of a Prototypical Synthetic Membrane-Active Antimicrobial: Efficient Hole-Punching via Interaction with Negative Intrinsic Curvature Lipids.” Proc. Natl. Acad. Sci., 105 (2008): 20595-20600. Som, A., Vemparala, S., Ivanov, I. and Tew G.N. ”Synthetic mimics of antimicrobial peptides.” Biopolymers 90 (2008): 83-93. Gabriel, G.J. and Tew, G.N. “Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers.” Org. Biomol. Chem. 6 (2008): 417-423. Beckloff, N., Laube, D., Castro, T., Furgang, D., Park, S., Perlin, D., Clements, D., Tang, H., Scott, R.W., Tew, G.N. and Diamond, G. “Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens.” Antimicrob. Agents Chemother. 51 (2007): 4125-4132. Yang, L., Gordon, V.D., Mishra, A., Som, A., Purdy, K.R., Davis, M.A., Tew, G.N. and Wong, G.C. “Synthetic antimicrobial oligomers induce a composition-dependent topological transition in membranes.” J. Am. Chem. Soc. 129 (2007): 12141-12147. Gabriel, G.J., Som, A., Madkour, A.E., Eren, T. And Tew, G.N. “Infectious disease: Connecting innate immunity to biocidal polymers.” Mater. Sci. Eng. R. Rep. 57 (2007): 28-64. Tang, H., Doerksen, R. J., Jones, T. V., Klein, M. L., and Tew, G. N. “Biomimetic facially amphiphilic antibacterial oligomers with conformationally stiff backbones.” Chem. Biol. 13 (2006): 427-435. Nusslein, K., Arnt, L., Rennie, J., Owens, C., and Tew, G.N. “Broad-spectrum antibacterial activity by a novel abiogenic peptide mimic.” Microbiology 152 (2006): 1913-1918. Arnt, L., Rennie, J.R., Linser, S., Willumeit, R. and Tew, G.N. “Membrane activity of biomimetic facially amphiphilic antibiotics.” J. Phys. Chem. B. 110 (2006): 3527-3532. Tew, G. N., Clements, D., Tang. H., Arnt, L. and Scott, R. W. “Antimicrobial activity of an abiotic host defense protein mimic.” Biochem. Biophys. Acta. 1758 (2006):1387-1392. Ivanov, I., Vemparala, S., Pophristic, V., Kuroda, K., DeGrado, W. F., Klein, M. L. "Characterization of Non-biological Antimicrobial Polymers in Aqueous Solution and at WaterLipid Interfaces from All Atom Molecular Dynamics", J. Am. Chem. Soc., 128 (2006): 1778.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Pophristic, V., Vemparala, S., Ivanov, I., Liu, Z., Klein, M.L. and DeGrado, W.F. “Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study.” J. Phys. Chem. B. 110 (2006): 3517-3526. Kuroda, K. and DeGrado, W. F. “Amphiphilic Polymethacrylate derivatives as antimicrobial agents.” J. Am. Chem. Soc. 127 (2005): 4128-4129. Tang, H., Doerksen, R. J. and Tew, G. N. “Synthesis of urea oligomers and their antibacterial activity.” Chem. Commun. (Camb) 28 (2005): 1537-1539. Ilker, M. F., Nusslein, K., Tew, G. N. and Coughlin, E. B. “Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives.” J. Am. Chem. Soc. 126 (2004): 1587015875. Liu, D., Choi, S., Chen, B., Doerksen, R. J., Clements, D. J., Winkler, J. D., Klein, M. D. and DeGrado, W. F. “Nontoxic membrane-active antimicrobial arylamide oligomers.” Angew. Chem. Int. Ed. 43 (2004): 1158-1158. Arnt, L., Nusslein, K. and Tew, G. N. “Nonhemolytic abiogenic polymers as antimicrobial peptide mimics.” J. Polymer Sci. 42 (2004): 3860-3864. Doerksen, R.J., Chen, B., Liu, D., Tew, G. N., DeGrado, W. F. and Klein, M.L. “Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers.” Chemistry 10 (2004): 5008-5016. Doerksen, R.J., Chen, B. and Klein, M.L. “Intramolecular hydrogen bonds: ab initio CarParrinello simulations of arylamide torsions.” Chem. Phys. Lett. 380 (2003): 150-157. Arnt, L. and Tew, G. N. “New poly(phenyleneethynylene)s with cationic, facially amphiphilic structures.” J. Am. Chem. Soc. 124 (2002): 7664-7665. Tew, G. N., Liu, D., Chen, B., Doerksen, R. J., Kaplan, J., Carroll, P. J., Klein, M. L. and DeGrado, W. F. “De novo design of biomimetic antimicrobial polymers.” Proc. Natl. Acad. Sci. USA 99 (2002): 5110-5114. Liu, D. and DeGrado, W. F. “De novo design, synthesis, and characterization of antimicrobial beta-peptides.” J. Am. Chem. Soc. 123 (2001): 7553-7559. Hamuro, Y., Schneider, J. P., and DeGrado, W. F. “De novo design of antibacterial betapeptides.” J. Am. Chem. Soc. 121 (1999): 12200-12201.

Presentations at Scientific Conferences: Scott R. “Host Defense (Antimicrobial) Peptides: Major Players in Health and Novel Therapeutics”. Oral symposium at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 10, 2012.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Jorgensen, D., Scott, R., Echols, R., Korczak B. “A Phase 2 Randomized Double-Blinded, Dose-Ranging, Active Controlled Efficacy and Safety Evaluation of PMX-30063 for the Treatment of Acute Skin & Skin Structure Infections (ABSSSI) Caused by Staphylococcus Aureus (SA)”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Scott R. Mithal S. Chen C.Y. “Nonpeptidic Mimics of Host Defense Proteins as Antimicrobial Agents for E. coli O104:H4, Campylobacter spp. and Other Foodborne Pathogens”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Scott R. Marchand C. Mithal S. “Nonpeptidic Mimics of Host Defense Proteins as Antimicrobial Agents for Category A and B Biowarfare Pathogens”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Scott R. Corrigan M. “Small Nonpeptidic Mimics of Host Defense Proteins Exhibit Potent Killing Activity Against Gram-Positive and Gram-Negative Biofilm Cultures”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Scott, R., Korczak, B., Jorgensen, D., Hawser, S., Hackel, M., Bouchillon, S., Xiong, Y., Bayer A. “Activity of PMX-30063 Against Drug Resistant Staphylococci”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Korczak B. Liu D. Scott R. “Metabolism and Excretion of PMX-30063: A Novel Class of Antibiotics”. Poster presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 11, 2012. Scott R. Korczak B. Watkins B. Sonis S. “Evaluation of a Nonpeptidic Mimic of Host Defense Proteins, PMX-30063, in an Animal Model of Oral Microsites”. Poster presentation at American Society of Clinical Oncology (ASCO), Chicago, IL, June 2, 2012. Morrisey, I., Dallow, J., Siegwart, E., Smith, A., Scott, R., Korczak, B. “The Activity of PMX30063 Against Staphylococci and Streptococci”. Poster presentation at the 22nd European Congress of Clinical Mictobiology and Infectious Diseases (ECCMID), London, UK, April 1, 2012. Scott, Richard W., Diamond, Gill, Ryan, Lisa K., Marsbury, Andrew, Freeman, Katie B., Tang, Haizhong. “Activity of an Antifungal Peptide Mimetic in an Experimental In Vivo Model of Oral Candidiasis”. Poster presentation at Keystone Symposia, Santa Fe, NM, January 18, 2012. Love, Melissa, Millholland, Melanie, Jo, Hyunil, Freeman, IKatie, Pan, Wenxi, Kavash, Robert W., Costanzo, Michael, DeGrado, William, Daly, Thomas M., Bergman, Lawrence W., Scott, Richard W., Greenbaum, Doron. “Host Defense Peptides and Small Molecule Mimics as Antimalarials”. Poster presentation at Keystone Symposia, Santa Fe, NM, January 18, 2012.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Korczak, B., Scott, R., Echols, R., Arezzo, J. “PMX-30063 Clinical and Preclinical Investigations of Transient, Treatment Related Neurosensory Effects”. Poster presentation at 49th Annual Meeting of Infectious Disease Society of America (IDSA), Boston, MA, October 21, 2011. Korczak, B., Scott, R., Sahm, D.F. “In vitro and ex-vivo Antimicrobial Activity of PMX-30063 – a Novel Mimic of Host Defense Proteins (HDP)”. Poster presentation at 49th Annual Meeting of Infectious Disease Society of America (IDSA), Boston, MA, October 21, 2011. R.W. Scott, H. Heine, R. Riggins. “Activity of Nonpeptidic Mimics of Host Defense Proteins against Bacillus anthracis in a Mouse Aerosol Challenge Model”. Poster Presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL, September 18, 2011. Scott, R. “Chemical Mimetics of Host Defense Proteins”. Oral presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL, September 17, 2011. B. Korczak, R. Echols, E. Walters. “Safety and Multiple Dose Pharmacokinetics of Intravenous PMX-30063: A Novel Class of Antibiotics”. Poster Presentation at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL, September 17, 2011. Scott, R., Corrigan, M, Kumar, N., Li, Y. Tew, G. “Novel Nonpeptidic Mimics of Host Defense Proteins as Active Agents for Antimicrobial Sutures”. Poster presentation at Association for Professionals in Infection Control (APIC), Baltimore, MD, June 27, 2011. Scott, R., Mithal, S., Chen, C.Y. “Nonpeptidic Mimics of Host Defense Proteins as Antimicrobial Agents for Foodborne Pathogens”. Poster presentation at the American Society for Microbiology (ASM), New Orleans, LA, May 24, 2011. Freeman, Katie B., Scott, Richard W., Costanzo, Michael J., Kavash, Robert W., Love, Melissa, Millholland, Melanie G., Jo, Hyunil, DeGrado, William, Greenbaum, Doron C. “Small Nonpeptidic Mimics of Host Defense Proteins as Potential Antimalarial Drugs”. Poster presentation at the American Society for Microbiology (ASM), New Orleans, LA, May 24, 2011. Freeman, K.B., Scott, R.W., Budu, C.E., Patel, M., Marlsbary, A., Diamond, G. “Identification of Novel Host Defense Protein Mimics for Treatment of Oral Candidiasis”. Poster presentation at the American Society for Microbiology (ASM), New Orleans, LA, May 23, 2011. Korczak, B., Echols, R., Walters, E. “PMX30063 – Understanding Neuronal Effects in MultiDose Phase 1 Clinical Study”. Poster presentation at the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy, May 9, 2011. Korczak, B., McAllister, E. “A Phase 1 Trial to Evaluate the Tolerability, Safety and Pharmacokinetics of Multi-Dose Intravenous Regiments of PMX30063”. Poster presentation at the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy, May 9, 2011. Korczak, B., Scott, R. “In Vitro Activity Profile of PMX30063 Against Recent Clinical Isolates of Gram-Positive and Gram-Negative Pathogens”. Poster presentation at the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy, May 8, 2011. January 2013

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Korczak, B., Arezzo, J., Scott, R. “Investigation of Potential Mechanisms Underlying Transient Paraesthesia Associated with PMX30063 Administration in Human Subjects”. Oral presentation at the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy, May 7, 2011. Scott, R.W., “Chemical Mimetics of Host Defense Proteins – Antimicrobial Activities”. Oral presentation at the 13th Annual Superbugs & Superdrugs Conference, London, UK, March 17, 2011. Korczak, B., “Chemical Mimetics of Host Defense Proteins – A Lesson from Nature”. Oral presentation at the 13th Annual Superbugs & Superdrugs Conference, London, UK, March 16, 2011. Korczak, B., McAllister, E., Scott, R.W. “Antimicrobial Activity in Human Serum After IV Administration of PMX-30063 in a Phase 1B Study”. Poster presentation at the American Society for Microbiology’s (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, September 15, 2010. Scott, R.W., Budu, C.E., Khanna, A., Clements, D. “Antimicrobial Activities of Structurally Diverse Host Defense Protein Mimics”. Poster presentation at the American Society for Microbiology’s (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, September 15, 2010. Scott, R.W., Mithal, S., Clements, D. “Antimicrobial Activities of a Novel Host Defense Protein Mimics Against Foodborne Pathogens”. Poster presentation at the American Society for Microbiology’s (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, September 15, 2010. Scott, R.W., Heine, H., Clements, D. “In Vitro Antimicrobial Activities of Nonpeptidic Mimics of Host Defense Proteins Against Biowarfare Pathogens”. Poster presentation at the American Society for Microbiology’s (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, September 15, 2010. Melhem, M., Forrest A., Bhavnani, S.M., Ambrose, P.G., Korczak, B., Rubino, C. “Population Pharmacokinetics of PMX-30063 After Single and Repeated Intravenous Doses”. Poster presentation at the American Society for Microbiology’s (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, September 15, 2010. McAllister, R.E. “An Approach to New Antibiotics for Avoiding Resistance: PMX-30063” 8th World Congress on Trauma, Shock, Inflammation and Sepsis (TSIS), Munich, Germany, March 11, 2010. McAllister, R.E., Korczak, B., Scott, R.W. “Human Safety and Pharmacokinetics of PMX-30063, A Small Nonpeptidic Mimetic of the Host Defense Proteins”. Poster presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 15, 2009.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Pulse, M.E., Weiss, W.J., Nguyen, P., Piece, J., Simecka, J., Scott, R.W. “Efficacy of PMX30063 in Experimental Staphylococcal Skin and Skin Structure Infection Models”. Poster presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 15, 2009. Scott, R.W., Clements, D., O’Leary A. “Pharmacokinetic-Pharmacodynamic Relationships for PMX-30063 in the Mouse Thigh Burden Model”. Poster presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September 15, 2009. Scott, R.W., Liu, D., Clemens D., Selbovitz M, Miller D., DeGrado W.F. “Developing new antibiotic approaches to controlling MDR/XDR TB in HIV patients on HAART”. Presentation at 5th International AIDS Society Conference, Cape Town, South Africa, July 21, 2009. Scott R.W., Mensa B., Clemens D., Caputo G., DeGrado W. “Antimicrobial Systemic Antibiotics: Small Molecule Mimics of Host Defense Proteins.” Presentation at 109th General Meeting of the American Society of Microbiology, Baltimore, Maryland, May 19, 2009. Scott, R.W, Miller D., Selbovitz M., Mensa B., Clements D., DeGrado W.F. “Selected antimicrobial compounds against M. tuberculosis show significant activity in vitro for more effective treatment in HIV co-infected patients.” Presentation at 22nd International Conference on Antiviral Research (ICAR), Miami, Florida, May 5, 2009. Scott R.W., Miller D, Selbovitz M, Gibbs J, Zive J, Norwood C. “Beyond INH: New classes of drug development for the treatment of multi-drug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) infections and global vulnerabilities of HIV+ drug users is a determining consideration for the development of defensin mimetics.” Presentation at 5th European Conference on Clinical and Social Research on AIDS and Drugs, Vilnius, Lithuania, April 28-30, 2009. Greenbaum D, Harbut M, DeGrado B, Bergman L, Scott R. “Small Molecule Mimetics of Antimicrobial Peptides as Antimalarials.” Presentation at Malaria Keystone Conference: Drug Discovery for Protozoan Parasites, Breckenridge, Colorado, March 23, 2009. Korczak, B. “A Novel I.V. Antibacterial Agent for Hospital Acquired Infections ” Presentation at SMi Superbugs & Superdrugs Conference - A Focus on Antibacterials, London, England, March 18, 2009. McAllister, E. “Development of a New Antibacterial Class.” Presentation at Healthtech Drug Development Conference: The Challenge of Antibacterial Drug Development, San Diego, California, March 18, 2009. Scott, R.W. “Nonpeptidic Mimics Of Host Defense Proteins: Development As IV Antimicrobial Agents.” Presentation at the Gordon Conference on Antimicrobial Peptides: Understanding Health and Disease through Antimicrobial Host Defense Peptides. Ventura, California, March 4, 2009.

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170 Radnor-Chester Rd., Suite 300, Radnor, PA 19087

484-598-2340

Scott, R.W. “Nonpeptidic Mimics of Host Defense Proteins: Activity against Category A Biopathogens”. Presentation at American Society of Microbiology 7th Annual Biodefense and Emerging Diseases Research Meeting, Baltimore, Maryland, February 24, 2009. Scott, R.W., Liu, D., Clements, D., Selbovitz, M., Miller, D., Cruz, G., Mensa, B., and DeGrado, W.F. “Novel Antimicrobial Molecules for Treatment of Mycobacterium tuberculosis”. Presentation at Keystone Symposia Global Health Series, Keystone, Colorado, January 28, 2009. Scott, R.W., Liu, D., Clements, D., Selbovitz, M., Miller, D., Cruz, G., Mensa, B., and DeGrado, W.F. “Antimicrobial Molecules for Treatment of Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Strains of Mycobacterium tuberculosis”. Presentation at HIV DART Conference, Puerto Rico, December 10, 2008. Scott, R.W., Korczak, B, Clements, D.J., Xu, Y., Liu. D. “In Vivo Efficacy and Safety of a Novel Host Defense Protein Mimetic, PMX30063: a Candidate IV Agent to Treat Staphylococcal Infections”. Presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., October 28, 2008. Scott, R.W., Xu, Y., Liu. D, Clements, D.J., DeGrado, W.F. “In Vitro Antimicrobial Activities of a Novel Host Defense Protein Mimetic, PMX30063, Against Multiple Isolates of Staphylococci with Defined Susceptibility Phenotypes”. Presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., October 28, 2008. Greenbaum, D., Scott, R.W., Liu, D., Chandramohanadas, R., Shanmugan, D., DeGrado, W.F. “Small Molecule Mimics of Antimicrobial Peptides as Potential Antimalarials”. University of Pennsylvania, Medical School. Platform presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., October 27, 2008. Diamond, D., Park, S., Perlin, D., Yamarthy, R., Felsenstein, S., Scott, R.W. “In vitro activity of novel biomimetic compounds against oral Candida strains”. University of Medicine and Dentistry of New Jersey. Presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., October 27, 2008. Scott, R.W., Clements, D.J., DeGrado, W.F. “Global Tuberculosis Epidemic and PolyMedix Solutions”. Presentation at New Directions in AIDS Treatment Research Policy and Care Symposium, New York, NY, September 26, 2008. Scott, R.W., Liu, D., Clements, D.J., Tang, T., Xu, Y., DeGrado, W.F. “Development of Synthetic Mimetics of Host Defense Proteins as Pan- Staphylococcal Antimicrobial Agents”. Presentation at GTC BIO Bugs and Drugs Conference, San Diego, CA, September 22-23, 2008. Weinkauf, H., Brehm-Stecher, B. “Wide-Spectrum Biomimetic Antimicrobial Systems”. Presentation at American Society of Microbiology 6th Annual Biodefense and Emerging Diseases Research Meeting, Baltimore, MD, February 24-27, 2008. January 2013

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Scott, R.W., Liu, D., Clements, D.J., Tew, G.N., DeGrado, W.F. “In Vivo Activities of Amphiphilic Biomimetic Compounds”. Presentation at the American Society for Microbiology's (ASM) Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, California, September 30, 2006.

Reviews - Antimicrobial Peptides Tossi, A., Sandri, L., and Giangaspero, A., “Amphipathic α-helical antimicrobial peptides.” Biopoly. 55 (2000): 4-30. Zasloff, M., “Antimicrobial peptides of multicellular organisms.” Nature, 415 (2002): 389-395. Beisswenger C. and Bals R.“Functions of antimicrobial peptides in host defense and immunity.” Curr Protein Pept Sci. 6 (2005): 255-264.

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