Annual Report Division of Cardiology Department of Medicine - Jewish General Hospital April 1, 2010 - March 31, 2011

I.

Highlights of Past Year

Having moved into our new out-patient facility, the Division focused on improving out-patient access to care. The pacemaker clinics are now running two days a week. Telephones are being answered with greater efficiency, and we have been making the appointment process easier for referring physicians. Our catheterization lab continue to provide cutting edge technology. Several of our staff are recipients of prestigious peer-reviewed grant awards for their research. The Division has hosted trainees from across Canada, Ireland, Greece and Israel. Dr. Regina Husa is now co-Director of the McGill Cardiology Postgraduate training program. Dr. Rudski was named to the Board of Directors of the American Society of Echocardiography, and Dr Sebag to the Canadian Society of Echocardiography. Our Echocardiography laboratory underwent a complete equipment renewal, keeping it at the state-of-the-art level, and making it an extremely attractive site for McGill, national and international trainees.

II.

Evaluation of Past Academic Year

1.

Teaching activities

CCU – Dr. Langleben, 375 hours. Dr. Rudski, Dr. Michel, Dr. Sebag, Dr. Shepard, Dr. Therrien – 175 hours each, Dr.Walling – 50hrs for a total of 1300 hours.

Consults: Dr. Langleben (80 hours), Dr. Michel (140 hours), Dr. Walling (40 hours), Dr. Sebag (70 hours, Dr. Shepard (70 hours), Dr. Eisenberg (120 hours), Dr. Therrien (140 hours), for a total of 660 hours. David Langleben MD

-Didactic Teaching : 2nd year medical students: Chest pain or palpitations: 2 hours -Postgraduate Cardiology Academic half Day: 4 hours -Medical residents and medical students: Pulmonary Hypertension: 18 hours -Postgraduate Respiratory Physiology course for fellows: Pulmonary Circulatory Physiology: 2 hours -PhD student, Gregory Star, supervisor Scientific and Professional Presentations: -Functional pulmonary microvascular surface area in PAH: Assessment and Relation to Disease Severity. University of British Columbia James ogg Research Seminar Series, Vancouver, BC -PAH: What we face and how we treat it, British Columbia Pulmonary Hypertension Society, Vancouver BC

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-Pulmonary endothelial metabolism in PAH: focus on ET-1 and angiotensin, Dalhousie University Queen Elizabeth Hospital Pulmonary Research Seminar, Halifax NS -Pulmonary hypertension and noncardiac surgery, JGH Department of Surgery Grand Rounds Lawrence Rudski MD

-CTU : 175 hours (5 weeks) -Cardiology Fellows Academic Half Days: 4 hours -Undergraduate Medical Students: ECG 1,2,3; Senior Physician Rounds: 1.5 hours -American Society of Echocardiography: Development of W b-based educational program on the evaluation of the right heart in the intensive care unit -American Society of Echocardiography: Development of symposia -Faculty of Medicine: Basis of Medicine - Unit 2 -Cardiology Small Group Sessions: Administrative Director Caroline Michel MD

-Continuous Training of Cardiology Fellows -Post doctoral echocardiography fellows trained (Dr. Su l Garg, Dr. Thierry Toledano) -Cardiology Fellows Trained in Heart Function Clinic (Dr. Chris Labos) -Internal Medicine Residents Trained in the Heart function Clinic (Dr. Michelle Edwards) -Core Curriculum Teaching for JGH Family Medicine Residents: The Management of Heart Failure in Office Practice -Clinical Lectures for Cardiology Fellows: Hypothermia post Cardiac Arrest -Teaching for Palliative Care Service Residents: Palliative Care in Cardiac Patients -CTU: (CCU) 175 hours (5 weeks) and Consults: 140 hours (4 weeks) -Clinical Innovation: Initiated Cardiac Palliative Care Program in the Hospital Ann Walling MD -POM examiner: 3 hours -2nd year medical students: Chest pain: 2 hours -Family Medicine Academic half day: 2 hours -Cardiology Academic Half day: 4 hours -McGill Echo Rounds: 1 hour -Post doctoral fellows trained: 1 year (Dr Sunil Garg, Dr. Thierry Toledano) -CTU: 50 hours -Consults: 40 hours -Echo lab: Continuous training of fellows (year 1-3) all year round. -Echo lab teaching of cardiology fellow (equivalent of 15 full weeks/yr): 525 hours -Cardiac Clinic: Supervisor of cardiology residents. 30 hours

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Igal Sebag MD Medical Students -Introduction to Internal Medicine: Technology in Medicine - EKG III: 1.5 hours -Senior Physician Rounds: 1.5 hours

-CTU: 175 hours (5 weeks) -Consults: 70 hours (14 days) Postgraduate Teaching (Cardiology and Internal Medicine) -A Primer on Physical Examination Part III: Recognition of right-sided disease: 2 hours -A primer on the methodology to echocardiographic interpretation: A case -based approach: 1 hour -A Primer on Physical Examination Part II: The diastolic murmur: 3 hours -Doppler, Color Flow Imaging and Hemodynamic Assessment: 1 hour -A Primer on Physical Examination Part I: The systolic murmur. 4 hours -Prosthetic heart valves: Anatomic structure of the various types, investigation and complications: 1 hour -Perfecting your skills in Physical Examination - Part III: 2 hours -Lecturer. Core Cardiology fellows: 3 hours Teaching to Post-doctoral fellows -3 Echocardiography Fellows: Dr. Sunil Garg, Dr. Thierry Toledano and Dr. Avi Shimony

-Course Director, McGill/Jewish General Hospital Echoca raphy Scientific Symposium -Board Examiner and Exam Developer, Cardiology (Adult) Examinations, Royal College of Physicians and Surgeons of Canada Teaching lectures at International Scientific Meetings -Quantification of the right ventricle by 3-D echocardiography : Are we there yet? American Society of Echocardiography Meeting, Montreal, QC -Trabeculations: Differentiating normal, from variant o mal, from LV noncompaction. Canadian Society of Echocardiography Meet ng, Toronto, ON -The role of echocardiography for transcatheter device closure of atrial septal defect. Canadian Society of Echocardiography Meeting, Toronto, ON -Myocardial function and structure in the murine model. American Society of Echocardiography, San Diego, CA Richard Shepard MD

-Monthly CCU lecture on CHF for the CCU resident team -Lecture on chest pain and palpitations given 3 times t d year medical students -CCU: 175 hours (4-6 weeks)

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-Consults: 70 hours. -Teaching of internal medicine residents who rotate through non invasive cardiology (stress testing) -Supervising residents rotating through the Heart Failure clinic at the JGH -Physical exam sessions for the cardiology fellows on t cademic half day: 12 hours -Academic half day teaching on Heart Failure management and evaluation: 4 hours Mark Eisenberg MD Medical Students -Introduction to Internal Medicine: Chest Pain and Palpitations: 2 hours Clinical Teaching to Cardiology Fellows, residents, Medical Students: -Cardiac Catheterization Laboratories:160 hours/year -Consultations: 120 hours/year Research-Related Teaching -Epidemiology Research Day for Cardiology Fellows (3 hours) Research Supervision: -Fellows, medical residents and post-doctoral fellows: Drs. Ali Abualsaud, Patrick Lawler, Avi Shimony -Graduate Students: Jennifer Reoch, MSc, Sarah Windle, MPH, Sunil Garg, MSc, Sonia Grandi, MSc -Thesis Supervisor: Lucy Boothroyd, PhD (co-supervisor) -Thesis External Examiner: Talal Ahmed A. Al-Khatib, MSc -Medical Students: Mehdi Tahiri, Clara Wu, Olivier Depl ntie, Salvatore Mottillo, -Undergraduate Students: Sayuri Friedland, Adrian Thorogood, Tara Dourian, Heather Robinson Student Bursaries: -CCORT Student Training Program: Mehdi Tahiri -McGill Medical Student Bursary Program: Clara Wu, Jennifer Reoch Continuing Educ ation -Aspirin, Plavix, and Coumadin in cardiac patients – Indications, risks, and benefits, McGill 61st Annual Refresher Course for Family Physicians, Montreal -Smoking cessation in cardiac patients: Medical students to meta-analyses to clinical trials, Royal Victoria Hospital, Cardiology Rounds, Montreal, Jewish General Hospital, Herzl Rounds, Montreal, QC and Montreal General Hospit rdiology Rounds, Montreal -Smoking cessation, McGill University, CCHPE Seminar Series, Montreal Academic -Aspirin for the primary prevention of cardiovascular disease, Lakeshore General Hospital

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Scientific and Professional Presentations -Perioperative stent thrombosis: Defining incidence, risk, and timing, American Heart Association Scientific Sessions, Chicago, IL -Canadian Cardiovascular Society position statement on s ing cessation, Canadian Cardiovascular Congress, Montreal, QC Judith Therrien MD

-Medical Students: Electrocardiography teaching, part II: 1 hour -CCU: 175 hours -Consults: 140 hours -McGill Cardiology Resident Teaching Sessions: Chest Radiography le ure; Aortic Regurgitation lecture; Tetralogy of Fallot lecture; Bicuspid Aortic Valve lecture (12 hours) -Mock Oral Cardiology Practice Royal College exam: Dr. Jonathan Affilalo, Dr. Sunil Garg -Post Grad Fellows: Dr. Colum Owen -Clinical Teaching: 12 hours /week (3 half days/week): Dr. Avi Shimon, Dr. Sunil Garg, and Dr. Thierry Toledano -Chief Organizer of the McGill Annual Cardiovascular Re rch Day Scientific and Professional Presentations: -Recovery of Right Ventricular Function and its Threshold, Annual International ACHD meeting, Oregon -Criteria for Pulmonary Valve Replacement in Adults wit ralogy of Fallot, New Orleans, AHA

2.

Research

Caroline Michel MD

-Etude du suivi des patients vus en urgence hospitaliere pour insuffisance cardiaque (ACCESS-URG) Trial-ongoing CIHR sponsored trial : Collaborator; Protocol FDHF01 – ongoing trial sponsored by Encysive Pharmaceuticals : Site Principal Investigator -EXACT Study: Using Allopurinol to relieve Symptoms in Patients with Heart Failure and High Uric Acid levels – Principal Investigator -Genetic Modulation of Left Ventricular Recovery in Recent Onset Cardiomyopathy (IMAC II) - Site Co-Investigator -Treatment Of Preserved Cardiac Function Heart Failure with an Aldosterone anTagonist (TOPCAT) - Site Co-Investigator

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-AliSkiren Trial ON Acute heart failure oUTcomes (ASTRONAUT) – Site CoInvestigator LEPHT: Randomized, double blind, placebo controlled, parallel group, multi-center study to evaluate the hemodynamic effects of Riociguat (BAT 63 2521) as well as safety and kinetics in patients with pulmonary hypertension associated with left ventricular systolic dysfunction – Site principal investigator -SWITCHBACK: The ACE – Switchback Study – Site Principal Investigator Igal Sebag MD Collaborative projects within McGill:

-Steroidal hormone programming in the heart: CIHR-funded collaborative work with the LDI (Dr. Lorraine Chalifour); Amount: $555,664, Term: October 2008 - September 2013. Role: Co-Investigator. The grant is authored by 2 investigators: Drs. L. Chalifour (PI, McGill) and I. Sebag. In this work, the influence of sex hormones on cardiac structure and function and their relationship to protein expression in calcium homeostasis is studied. -Aortic disease in murine models of bicuspid aortic disease: this ongoing research encompasses the study of aortic root disease in the presence of the bicuspid aortic valve in the murine model. This project, led by Dr. Therrien (MAUDE Unit), includes Drs. Lorraine Chalifour (LDI), Dr. Elaine Davis (Dept. of Cell Biology and Anatomy), Karima Addetia, a cardiology fellow and myself. Collaborative projects outside McGill:

-Collaboration with the CHUM Research Center, Université de Montréal. In this collaborative work with Dr. Damien Garcia (CHUM Research Center), we aim at developing a fast unsupervised denoiser and dealiaser algorithm for color Doppler raw data, the premiere modality to analyze blood flow in c inical echocardiography. -International collaborative research (with Massachusetts General Hospital, Boston, MA) Source: Susan Komen For the Cure Investigator Initiated Grant; Title: Early detection and prediction of chemotherapy-induced cardiotoxicity in breast cancer patients; Amount: $600,000 Term: July 2008 - July 2011; Role: Co-Investigator. The grant is authored by 4 investigators: Drs. M. Scherrer-Crosbie (PI, Massachusetts General Hospital), I.A. Sebag (McGill), JC. Plana (MDAnderson) and B. Ky (Upenn); Site PI for the conduct of this trial. The team is constituted by a research nurse, four cardiac sonographers, an oncologist (Dr. V. Cohen) and an oncology nurse. As a result, our site is the strongest patient recruitment centre of all four participating institutions (the JGH 6

recruited 31 patients out of a total of 46 patients). Interim results have been publi second manuscript which integrates the final results i n preparation.

d. A

Richard Sheppard MD Collaborative research heart failure clinical trials with Montreal Heart Institute: -CARRESS Trial -TOPCAT Trial -EXACT Study Colaborative research heart failure clinical trials wi h the McGill University Health Center -ASTRONAUT Trial Collaborative work with University of Pittsburgh Medic nter -Cohort study examining natural history of peripartum cardiomyopathy (PPM Study)

-Ongoing work on manuscripts and abstracts for the IMAC y looking at the natural history of acute non ischemic cardiomyopathy, with col gues at the University of Pittsburgh Medical Center, submitted manuscript exploring sudden cardiac to JACC -Initiated protocol with HF research coordinator, examining the role of stress hormones on cardiac remodeling post-myocardial infraction (received institutional funding). -Recently started supervising internal medicine resident Khalid AlJohani in a meta analysis examining the impact of genetic polymorphisms on clinical outcomes in heart failure (along with Dr. Eisenberg). Mark Eisenberg, MD Collaborative Projects

-Co-Investigator, “Quantification of the effect of SMOKing on arterial stiffness (SMOKELESS).” Principal Investigator: Styliani Stella lopoulou (McGill University). -Principal Investigator, “The efficacy of weight loss i erventions: A systematic review and hierarchical Bayesian meta-analysis.” Co-Investigators: Kristian Filion, Jacques Genest, Lawrence Joseph, Louise Pilote (McGill University); Ernesto Schiffrin (Sir Mortimer B Davis Jewish General Hospital); Paul Poirie niversité Laval). -Co-Investigator, “GENESIS PRAXY (GENdEr and Sex determInantS of cardiovascular disease: from bench to beyond PRemature Acute Coronary SYndrome).” Principal Investigators: Louise Pilote, Igor Karp (McGill University). 7

-Co-Investigator, “Canadian cardiovascular outcomes research team (CCORT) II: Access to quality cardiac care. Team grant in improvement of quality of cardiac care to Canadians.” Principal Investigator: Jack Tu (Institute for Clinical Evaluative Sciences). -Co-Investigator, “AMI-QUEBEC-2: Knowledge translation to reduce delays to reperfusion therapy in Quebec.” Principal Investigator: Thao Hu McGill University). -Principal Investigator, “The efficacy of popular diets: A systematic review and hierarchical Bayesian meta -analysis.” Co-Investigators: Kristian Filion, Jacques Genest, Lawrence Joseph, Louise Pilote (McGill University); Ernesto Schiffrin (Sir Mortimer B Davis Jewish General Hospital); Paul Poirier, Stephane Rinfret (Université Laval). -Co-Investigator, “A population-based analysis of the effectiveness and adverse effects of medications in patients with atrial fibrillation.” Principal Investigator: Louise Pilote (McGill University). David Langleben, MD

-Pulmonary microvascular metabolic function – collaboration with Drs Stylianos Orfanos of the University of Athens, Greece, and Dr. John Catravas of the Medical College of Georgia, USA -Colum Owens, Giuseppe Martucci, Richard Leask, Ariane Marelli, Avi Shimony, David Langleben, Judith Therrien. Anatomical Considerations for the Development of a New Transcatheter Aorto-Pulmonary Shunt in Patients with Pulmonary Arterial Hypertension Project in Collaboration with McGill Mechanical Engine ring Department Judith Therrien, MD

-Therrien J, Lonn E, Silversides C, Salehian O, Grewal J, Vondermuhll I, Siu S. Effects of Beta Adrenergic Blocker and Angiotensin Receptor Blocker On Aortic Dilatation in Adults with Bicuspid Aortic Valve -Expert Panel on :Developing a Quality Assessment Tool for Adults with Congenital Heart Disease. Children’s Hospital Boston, Harvard Med cal School, 2011. Mark Eisenberg MD

-Exploring legislative approaches to obesity epidemic -Investigating the effects of low-dose ionizing radiation Eisenberg MJ, Afilalo J, Lawler PR, Abrahamowicz M, Richard H, Pilote L. Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction. CMAJ 2011;183:430-6. 8

-Lawler PR, Afilalo J, Eisenberg MJ, Pilote L. Exposure to low-dose ionizing radiation from cardiac imaging among patients with myocardial in tion: Data from a population-based longitudinal cohort. Submitted. 3.

Clinical activities

CCU Admissions - 1141 2 Cardiac CTU Admissions – 2133 Pacemaker Program - 2127 Cardiology Clinic Visits - 839 Physician consults - 2034 GFT Physicians - 6517 Diagnostic Cardiac Catherizations – Coronary Angioplasties – Primary Coronary Stenting – Echocardiograms – 7707 Electrocardiograms – 15386 Holter monitorings/Ambulatory BP monitorings – 1320 Exercise Stress tests –1028 Cardiac Stress Nuclear Imaging - 1074

4.

Academic Staff

Dr Sven Wassmann left the Division to take up clinical ctice in Germany. The Division has made commitments to Dr Vartan Mardigyan, who will arrive July 2011, Dr Annabel Chen-Tournoux, who will arrive Fall 2011, and Dr Jonathan Afilalo, who will arrive July 2012.

5.

Consulting activities

Name of Faculty Private Sector Public Sector Member Consulting (# of Consulting (# days) days) David 11 1 Langleben Igal Sebag 2 1

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Other (# of days Total – please explain) 12

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Honours, Awards and Prizes

Igal Sebag MD

-Promoted to Associate Professor of Medicine (starting January 1, 2011), McGill University, Montreal, Quebec 9

-Recipient of the David Stubington Teacher of the Year Award for outstanding teaching in the McGill Cardiology training program, McGill University, Montreal, Quebec Mark Eisenberg MD

-Graduated with M. Management from International Masters for Health Leadership (McGill University Faculty of Management, Montreal, QC) -Published “The Physician Scientist’s Career Guide” 7)

Other: Publications, Abstracts, etc.

--*Abu Alsaud A, *Afilalo J, Eisenberg MJ. Very early invasive versus less early invasive strategies for non-ST -elevation acute coronary syndromes: A meta -analysis of randomized trials. Can J Cardiol 2010; 26:S30D. --*Abualsaud AO, Eisenberg MJ. Perioperative management of patients with drugeluting stents. JACC Cardiovasc Interv 2010; 3:131-42. --*Afilalo J, Rasti M, Ohayon S, Eisenberg MJ. Meta-regression of off-pump versus on-pump coronary artery bypass surgery. Can J Cardiol 2010; 26:S101D. --*Afilalo J, *Lawler PR, Pilote L, Richard H, Eisenberg MJ. The carcinogenic effects of ionizing radiation from cardiac imaging procedures after acute myocardial infarction: a population-based longitudinal study. Can J Cardiol 2010; 26:S65D. --*Afilalo J, Eisenberg MJ, Morin JF, Bergman H, Monette J, Noiseux N, Perrault LP, Alexander KP, Langlois Y, Dendukuri N, Chamoun P, Kasparian G, Robichaud S, Gharacholou SM, Boivin JF. Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol 2010; 56:1668-76. --*Afilalo J, *Lawler PR, Richard H, Pilote L, Eisenberg MJ. Age and sex differences in risk of cancer with low dose ionizing radiation from cardiac imaging procedures after acute myocardial infarction. Circulation 2010; 122:A17486. Eisenberg MJ, Atallah R, Grandi SM, Windle SB, Berry EM. Legislati tackling the obesity epidemic. CMAJ 2011; DOI:10.1503/cmaj.101522.

approaches to

--*Friedland S, Eisenberg MJ, *Shimony A. Intracoronary versus intravenous administration of glycoprotein IIB/IIIa inhibitors duri percutaneous coronary intervention for acute coronary syndromes: A meta -analysis of randomized controlled trials. Presented at: 9th Annual McGill Cardiovascular Research Day; February 1 11; Montreal, QC.

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--*Grandi SM, *Shimony A, Pilote L, Gervais A, Joseph L, O'Loughlin J, Paradis G, Rinfret S, Sarrafzadegan N, Adamjee N, Yadav R, Gamra H, Sharma S, Lauzon C, Eisenberg MJ, for the ZESCA Investigators. Utilization of evidence-based therapy for acute coronary syndrome in developed and developing countries. Presented at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; real, QC. --*Lawler PR, Filion KB, Eisenberg MJ. Correcting anemia in heart failure: The efficacy and safety of erythropoiesis-stimulating agents. J Card Fail 2010; 16:649-58. --*Lawler PR, *Afilalo J, Pilote L, Richard H, Eisenberg MJ. Temporal trends in the use of low-dose ionizing radiation-associated cardiac imaging in Quebec: A longitudinal cohort study. Can J Cardiol 2010; 26:S41D. Also presen d at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. --*Lawler PR, Filion KB, Eisenberg MJ. A meta-analysis of exercise -based cardiac rehabilitation for secondary prevention following myocardial infarction: Does duration matter? Presented at: European Society of Cardiology Meeting 2010. --*Lawler PR, *Afilalo J, Pilote L, Richard H, Eisenberg MJ. Exposure to low-dose ionizing radiation from cardiac imaging among patients ith myocardial infarction in Canada: 10-year data from a large Canadian longitudinal cohort. C rculation 2010; 122:A19280. --*Mottillo S, Filion KB, Joseph L, Genest J, Pilote L, Poirier P, Rinfret S, Schiffrin E, Eisenberg MJ. The metabolic syndrome and cardiovascular risk: A systematic review and meta-analysis. J Am Coll Cardiol 2010; 56:1113–32. --*Reoch J, *Mottillo S, *Shimony A, Filion KB, Christou , Joseph L, Poirier P, Eisenberg MJ. Safety of laparoscopic vs. open bariatric surgery: A systematic review and meta-analysis. Presented at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. Also presented at: 9th Annual LD MacLean General Surgery Day; April 6, 2011; Montreal, QC. --*Shimony A, *Filion KB, *Mottillo S, Eisenberg MJ. Diagnosis of acute aortic dissection by d dimer - a meta analysis. Can J Cardiol 2010; 26:S60D. Present at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. --*Shimony A, Eisenberg MJ, Filion KB, Amit G. Beneficial effects of right ventricular non-apical versus apical pacing: A systematic review and meta -analysis of randomized controlled trials. Presented at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. --*Shimony A, Pilote L, Karp I, Eisenberg MJ, on behalf of the GENESIS-PRAXY Investigators. Sex differences in angiographic characteristics of young patients with acute coronary syndrome. Can J Cardiol 2010; 26:S121D. 11

--*Shimony A, *Mottillo S, Eisenberg MJ. Coronary artery perforation during percutaneous coronary interventions - A meta-analysis. Can J Cardiol 2010; 26:S129D. --*Shimony A, Filion KB, *Mottillo S, *Dourian T, Eisenberg MJ. Meta-analysis of usefulness of D-dimer to diagnose acute aortic dissection. Am J Cardio 2011; 107:122734. Epub. --*Shimony A, Eisenberg MJ, Rudski L, Schlesinger R, Afilalo J, Joyal D, Dragatakis L, Hirsch A, Boutet K, Fox BD, Langleben D. Prevalence and impact of coronary artery th disease in pulmonary arterial hypertension patients. P sented at: 9 Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. --*Tahiri M, *Mottillo S, Joseph L, Pilote L, Eisenberg MJ. Unconventional smoking cessation aids: A meta -analysis of randomized controlled trials. Presented at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; real, QC. --*Wu CQ, *Mottillo S, Giannetti N, Huynh T, Joseph L, P lote L, Walker M, Eisenberg MJ. Patient empowerment interventions: A systematic review of randomized controlled trials. Presented at: 9th Annual McGill Cardiovascular Research Day; February 17, 2011; Montreal, QC. --ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensu document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol 2010; 55:2663-99. Task Force Internal Reviewer (Eisenberg MJ) --Addetia K, Sebag I, Marelli A, Martucci G, Therrien J. Right Ventricular End Diastolic Wall Stress: a new Marker for Right Ventricu ar Dysfunction. Submitted to Echocardio 2010. --Affilalo J, Therrien J, Pilote L, Martucci G, Marelli A. Adults with congeni al Heart Disease, a Geriatric Perspective. Accepted in JACC 2011 --Beauchesne LM, Therrien J, Alvarez N, Bergin L, Burggraf G, Chetaille P, Gordon Kells C, Kiess M, Mercier LA, Oechslin EN, Stein J, Tam JW, Taylor D, Williams A, Marelli A. Status of adult congenital heart disease cl n Canada: a survey on infrastructure, resources and clinical volumes. IJC 2010 Dec 27[Epub ahead of print] --Boris L, Marelli A, Martucci G, Therrien J. Adult Congenital Heart Disease: the Right Gone Wrong. Submitted to JACC 2010. --Bouchardy J, Marelli A, Martucci G, Therrien J. Mirror Image Atrial Dilatation in Adult Patients with Congenital Heart Disease and Atria Fibrillation. Submitted to European Heart J 2010. 12

--Chaudhry R, Chaudhry F, Huynh T, Lader E, Rashid S, Ok c K, Wou K, Eisenberg MJ. Effect of smoking on age at the time of coronary artery bypass graft surgery; Baseline data results from the ROSETTA-CABG registry. Heart Asia 2010; 2:48-51. --Corris PA, Langleben D. The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. (letter). Eur Respir J 2010;35:460-461. --Do Changes in Echocardiographic Parameters Predict Sur val in Patients with Heart Failure?: Karima Addetia, Caroline Michel, Christina Holcroft, Richard Sheppard, Lawrence Rudski, McGill Univ, Montreal, QC, Canada – to be presented at the AHA, Nov, 2011 --Do DH, Therrien J, Marelli A, Martucci J, Afilalo J., Sebag IA. Right atrial size relates to right ventricular end-diastolic pressure in an adult population with congeni l heart disease. Echocardiography 2011; 28:109-16. ---Ehrmann Feldman D, Ducharme A, Giannetti N, Frenette M, Michel C,Grondin F, Sheppard R, Des Lauriers J, Behlouli H, Pilote L. Outcomes for women and men who atttend a heart failure clinic: Results of a 12-month longitudinal study. J Cardiac Fail 2011; 17: 540-546. --Ehrmann Feldman D, Ducharme A, Giannetti N, Frenette M, Michel C, Grondin F, Sheppard R, Des Lauriers J, Behlouli H, Pilote L. Outcomes for women and men who attend a heart failure clinic: Results of a 12-month longitudinal study. J Cardiac Fail 2011; 17: 540-546. --Eisenberg MJ, *Afilalo J, *Lawler PR, Abramovitch M, Richard H, Pi L. Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients following acute myocardial infarction. CMAJ 2011; 183:430-6. Epub. --Eisenberg MJ. The Physician Scientist’s Career Guide. Springer 2010. This book is based on both first-hand experiences and scientific research into the physician-scientist career path. Filled with practical advice, this comprehensive guide helps trainees at all stages of medical and research training succeed in their careers. --Eisenberg MJ, Blum LM, Filion KB, Rinfret S, Pilote L, Paradis G, Joseph L, Gervais A, O’Loughlin J. The efficacy of smoking cessation the ies in cardiac patients: A metaanalysis of randomized controlled trials. Can J Cardiol 2010; 26:73-9. --Eisenberg MJ, *Grandi S, Gervais A, Joseph L, O'Loughlin J, Paradi Rinfret S, Sarrafzadegan N, Sharma S, Lauzon C, Gamra H, Wightman utchmedial S, Picard J, Giannoccaro P, Huynh T, Diodati JG, Grondin F, Klinke P, Wielgosz A, Abramson B, Schwarz N, Pilote L. Bupropion for smoking cessation following acute coronary syndrome. Can J Cardiol 2010; 26:S110D. 13

--El-Rayes M, Schampaert E, Tardif JC, Eisenberg MJ, Afilalo M, Kouz S, Lauzon C, Harvey R, Nguyen M, Kouz R, Dery JP, Mansour S, Van Ki u AM, Rinfret S, Huynh T. Safety and effectiveness of enoxaparin following fibri lytic therapy: Results of the Acute Myocardial Infarction (AMI)-QUEBEC registry. Can J Cardiol 2010; 26:431-6. –Manuscript submitted for publication: Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression and DNA methylation analyses in adult mice. (I.A. Sebag: first author; L. Chalifour: senior author) --Feldman DE, Ducharme A, Giannetti N, Frenette M, Michel C, Grondin F, Sheppard R, Lauriers JD, Behlouli H, Pilote L. Can J Cardiol. Severity at entry to specialized heart failure clinics: discrepancies between health-related quality of life and function in men and women