2014

Annual Meeting and Exhibits

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Scientific program

leading since 1999

ISBER 2014 Annual Meeting & Exhibits ‘Fact not Fantasy: Evidence-Based Biobanking’ May 20-24, 2014 • Orlando, FL, USA

ISBER Vision ISBER will be the leading global forum for promoting harmonized high quality standards, ethical principles, and innovation in the science and management of biorepositories.

ISBER Mission ISBER is a global organization which creates opportunities for sharing ideas and innovations in biobanking and harmonizes approaches to evolving challenges for biological and environmental repositories.

International Society for Biological and Environmental Repositories Head Office: 570 West 7th Avenue, Suite 400, Vancouver, BC, V5Z 1B3, Canada T: 1-604-484-5693 • F: 1-604-874-4378 • E:[email protected]

www.isber.org

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

ISBER 2014 Corporate Partners ISBER gratefully acknowledges the generous support of our Corporate Partners:

Platinum Corporate Partners

Gold Corporate Partners

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Table of Contents Message From Scientific Program Committee & President

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ISBER 2013 – 2014 Board of Directors

9

ISBER Committees & Working Groups

10

ISBER 2014 Award Winners

11

General Information

12

Venue Map

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Exhibition Plan & List Of Exhibitors

14

Exhibition Passport

20

Pre-Conference Workshops

22

Scientific Program

24

Invited Speaker Summaries

33

ISBER Education & Training Workshops

36

Posters

44

2014 Annual Meeting Sponsors

50

Speakers & Chair Index

62

Poster Index

62

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International Society for Biological and Environmental Repositories

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Message from the Scientific Program Committee and President Dear Colleagues and Friends, Welcome to the 2014 Annual Meeting & Exhibits of the International Society for Biological and Environmental Repositories (ISBER). The ISBER Annual Meeting & Exhibits provides a global forum for discussion of a broad range of issues related to the establishment and operation of a wide variety of biorepositories including human, animal, seed, museum and environmental collections. Meeting Highlights: We are happy to explore a new locale for the ISBER meeting, in sunny Orlando, Florida, USA, the theme park capital of the world. Our meeting is being held in the Walt Disney World Swan and Dolphin Hotels, near Walt Disney World, Universal Studios and SeaWorld. ISBER is the only global forum serving all members of the biobanking community and the ISBER Annual Meeting & Exhibits continues to be the key meeting for biorepository operators, scientists, consultants and vendors. The 2014 Scientific Program Committee has worked extremely hard this past year on our theme of “Fact not Fantasy: Evidence-Based Biobanking.”  With the meeting held in an environment surrounded by fantasy, the main focus will be on evidence-based biobanking from collection to use. The meeting will highlight unique and interdisciplinary best practices of both human and environmental repositories with regard to sample integrity, availability, interrogation and reliability of results. These explorations will accelerate the biobanking community toward improved repository management, leading to better scientific decisions and enhanced global and environmental health. Plenary Symposia: We have invited world leaders in the field of biobanking and beyond who will emphasize the rapidly evolving research environment and the importance of having repositories practices adhering to processes that have been shown to be most effective in maintaining the specimens as true to their in vivo state as possible. The speakers in Symposium 1 (Wednesday morning) will report their experiences that highlight “Advancing Science through Evidence-based Biobanking.” In the Keynote presentation, Dr. Rex Chisholm presents “Integration of Biobanks into Clinical Health Care through Linkage to Medical Records—The eMERGE experience.” This is followed by “The Australian Plant Bank – Safeguarding Plants for the Future” (Dr. John Siemon), “Geisinger’s MyCode Project: Leveraging Genomics and EMR Data to Improve Patient Outcomes” (Dr. David Ledbetter), and finally “Cell Processing and Preservation for Biobanking: New Horizons” (Dr. Erik Woods). This session sets the theme of our meeting. On Wednesday afternoon, Symposium 2 is entitled “Translational Science through Biobanking: Applications and Opportunities.” Wednesday will end with the Opening Reception to visit posters, exhibits and to connect with friends and colleagues. Thursday morning features two concurrent symposia that both will feature talks and an interactive discussion. Symposium 3A highlights issues of “Financial Sustainability of Biobanks” and Symposium 3B focuses on “Model Organisms and Biodiverse Biorepositories: Interdisciplinary Perspectives in Biobanking.” On

Friday morning, Symposium 4 will focus on “Biospecimen Science” and our final plenary in the ISBER program is on Saturday, “Biospecimen Identifiability, Privacy and Broad Data Sharing.” Special Topic Sessions: Wednesday’s activities will open with a “Getting to Know ISBER” Breakfast Session for any new or potential members. This is a valuable chance to meet and ask questions of several ISBER members that have been highly involved in the Society. You will hear some of the history of ISBER and meet several of the Council members. On Thursday mid-morning, ISBER will host a session highlighting Innovative Technologies. The focus of this session will be on the science and validation behind new products and technologies that have the potential to impact biorepository operations and specimen management/ workflow. Presentations were selected from the abstracts submitted to the “Innovative Technologies” category. On Friday afternoon, a special topic session on “Important Biobanking Developments in Europe” will run concurrently with our annual Interactive Discussions. The interactive discussions are focused on late breaking and special interest topics that are submitted by the ISBER membership. Please sign up for the Interactive Discussions at the ISBER Registration desk to assure a seat at one of the tables. Working Group Meetings and Contributed Papers: You will note that each day, meetings are scheduled for the ISBER Working Groups and Special Interest Groups. Please feel free to join any of the open sessions, the schedule is listed in the program. It is very encouraging that we have received our largest number of submitted abstracts 209 yet – to our ISBER Annual Meeting & Exhibits and all of the accepted abstracts are in the online abstracts that are published online in the April issue of Biopreservation and Biobanking (BIO). From the submitted abstracts, we have selected 33 oral presentations to be presented on Thursday and Friday afternoon. In the exhibit hall, there will be 159 posters displaying the richness and diversity of the interests of ISBER members, providing you with a great opportunity to learn and interact with presenters on a wide variety of biobanking topics. Authors were required to submit their posters early to be eligible to be judged for the ISBER Outstanding Poster Awards. High Variety of ISBER Activities: Educational and corporate workshops, contributed oral and poster presentations, exhibits, and two receptions are planned to complete your experience. We encourage you to spend time in our largest vendor exhibition to date. There are nine Education and Training Pre-Conference Workshops scheduled for the Tuesday morning, May 20, preceding the meeting (three concurrent tracks). These cover a range of topics including: “Fit for Purpose” Protocol Planning: A Tutorial to Facilitate Evidence Focused Biobanking Practice – in Real Time”, “Surveys, Migration, and Changes – Informatic Considerations for Biobanks”, “Are You Prepared? Case

5 www.isber.org

Studies in Balancing Biospecimen-related Patient and Investigator Requests with Risk Management and Human Subjects Protections in the Age of Genomic Medicine,” “Implementing Robust Quality Management Systems for Repositories”, “Biospecimen Science: Learning from Cryobiology to Improve Preservation Outcome”, “Keep Your Samples Safe: Choose the Appropriate Storage Container”, “Limitations in the Use of Human and Animal Tissues in Research: What Biorepositories and Investigators Need to Know”, and “Issues to Consider in Designing a Repository / The Nuts and Bolts of Operating a Repository”. Two of the Pre-Conference Workshops are part of the ISBER Certified Repository Technician Program and are entitled, “Essential Concepts for Effective Specimen Receipt” and “Creating Successful Training Programs for Repository Staff.” There are also special workshop sessions on “Come Hell or High Water: Disaster Preparedness for Biospecimen Collections” by Nigel Brockton, Charlene Karvonen, “Informed Consent for Genomics: Policies, Problems and Practical Approaches” by Marianna J. Bledsoe, Amelia Warner,  Anita Nelsen, “Weathering the Storm: Assessing Business Continuity Measures in Biorepository Operations” with Kristina Robson and Andrew Brooks and “ELSI Challenges in Biobanking & Genomics Research” with   Pedro Rondot Radío,  Rosario Isasi,  Anne Marie Tassé within the main program on Saturday morning. ISBER Awards Presentation and Business Meeting: The ISBER Awards Presentation and Business Meeting will include an overview by ISBER President, Fay Betsou, of the accomplishments of our society over the past year, ISBER’s finances, and major changes in ISBER’s strategic vision for the membership and attendees. We encourage all meeting participants to attend the business meeting. Special Service Awards and the ISBER Distinguished Leadership and Service Award will be presented. ISBER is excited to have Taylor-Wharton as the sponsor of the 5th ISBER Award for Outstanding Achievement in Biobanking, which will be presented during the meeting. We will also announce the results of the recent ISBER elections. Please attend to meet your new PresidentElect and ISBER Directors-at-large. We will also hold the draw for the exhibitor passport prize – you must be present to win! The poster awards will also be announced and presented during the Business Meeting. To be eligible to be judged for these awards, the poster submissions must have been sent in early to the ISBER Head Office. Thank you for active participation in these programs. The ISBER Poster Awards recognize excellence in poster presentations at the annual meeting. This year the awards will be limited to investigators who are new in biobanking.  The goal of the ISBER Poster Award is to encourage ISBER members and all attendees of the annual meeting who are new investigators in biobanking to ask important original questions about biobanking and biospecimen science, to design sound, controlled experiments with a clear rationale, and to present the results clearly in a poster format. Award winning posters will be selected by an Awards Subcommittee of the ISBER Puvblications Committee. The award, which includes a stipend and award certificate, will be presented to the new investigator at the ISBER Business Meeting.

5K Fun Run/Walk: The Membership and Marketing Advisory Committee has planned the 3rd Annual ISBER 5K Fun Run/1M Walk/Sleep Walk on Thursday morning. We thank Taylor-Wharton for its generous support. Special thanks to Jay Yakabowich for leading the Fun Run subcommitee efforts! All proceeds raised from the Fun Run will benefit the ISBER Global Expansion Fund which supports the Society’s efforts to increase involvement and membership of researchers worldwide. The fund provides travel support for individuals from emerging countries to attend the ISBER Annual Meeting & Exhibits. We have two biobankers from Nigeria and Uganda in attendance at ISBER 2014 due to the generous support provided by the proceeds of previous ISBER 5K Fun Run/Sleep Walk. Online and onsite registration for the 2014 ISBER 5K Fun Run/Sleep Walk is available at the registration desk. Sign up today! Special Acknowledgements: We gratefully acknowledge all who provided so much input and effort into the planning and implementation of the meeting. A special thank you to Dr. Bas de Jong for his contribution to the 2014 Scientific Program. Many thanks to the members of the ISBER 2014 Scientific Program Committee, and the Organizing Advisory Committees, to the Chairs and members of the ISBER Education and Training Advisory Committee, the ISBER Membership and Marketing Advisory Committee, the ISBER Publications Advisory Committee, the ISBER Board of Directors and to the ISBER Head Office staff. We also thank our invited speakers and workshop presenters for their contributions to the program. Finally, we sincerely appreciate the support from our vendors, sponsors and corporate partners, without whom the meeting would not be possible! We hope that the scientific program organized by the Program Committee will meet your highest expectations. To guarantee future successful meetings we will need your help, either by joining the different committees and workshops, or by filling out the online meeting survey that is sent to all participants at the end of the meeting. We look forward to your participation and we are looking forward to a successful Annual Meeting & Exhibits. We welcome both our established and new colleagues to this event! We hope that our new colleagues will consider joining our Society as members to take advantage of the yearround interactions that our members enjoy. Our Society continues to grow globally stronger, as we represent more sectors of our biorepository community, and we welcome your participation. Enjoy reconnecting with current friends and making new ones. The biorepository field is exciting and undergoing rapid change and ISBER will help chart the future course with your participation! Thank you for your participation and enjoy the meeting. With kind regards, Jodi Black, PhD, MMSc • Marianne K. Henderson, MS Co-Chairs of the ISBER 2014 Scientific Program Advisory Committee Fay Betsou, DrSc HDR ISBER President, 2013-2014

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International Society for Biological and Environmental Repositories

Open Workshop & Networking Event

Enter our tube game to win a kindle Fire at booth #207/306

Attend TTP Labtech and CryoXtract’s joint workshop:

Managing the past for the future May 20th, 5.15pm – 6.15pm (post workshop refreshments will be available)

Learn about innovative workflow solutions for maintaining sample integrity at

discover.ttplabtech.com/ISBER2014

ISBER 2014 Scientific Program

ISBER 2013-2014 Board of Directors BOARD OF DIRECTORS President May 2013 – 2014

Treasurer May 2013 – 2014

Secretary-Elect May 2013 – 2014

Director-at-Large May 2012 – 2015

Fay Betsou, DrSc HDR Luxembourg

Cheryl Michels Mountlake Terrace, WA, United States

Katherine Sexton, MBA Birmingham, AL, United States

Paul Bartels, PhD, BVSc Pretoria, South Africa

Secretary May 2013 – 2014 Treasurer-Elect May 2014 – 2017

Director-at-Large May 2011 – 2014

Director-at-Large May 2012 – 2015

Lori Campbell, PhD Manassas, VA, United States

Rebecca Pugh, MS Charleston, SC, United States

Director-at-Large May 2011 – 2014

Director-at-Large May 2013 – 2016

Jane Carpenter MAppSci, FIBMS Westmead, NSW, Australia

Brent Schacter, MD FRCPC Winnipeg, MB, Canada

Science Policy Advisory Committee Co-Chairs

2014 Scientific Program Advisory Committee Co-Chairs

Organizing Advisory Committee Chair

Nicole Sieffert, CCRC Houston, TX, United States

Jodi Black, PhD, MMSc Bethesda, MD, United States

Marianne Henderson, MS Bethesda, MD, United States

Tyron C. Hoover, MD, JD FCLM FCAP Houston, TX, United States

Marianne Henderson, MS Bethesda, MD, United States

Executive Director

President-Elect May 2013 – 2014 Andy Zaayenga Martinsville, NJ, United States Past President May 2013 – 2014 Katheryn E. Shea Frederick, MD, United States

Education and Training Advisory Committee Co-Chairs Nicole Sieffert, CCRC Houston, TX, United States Alexandra F. Lerch-Gaggl, MSc, PhD Milwaukee, WI, USA Publications Advisory Committee Chair Marianna Bledsoe, MA Washington, DC, United States

Heather Siefers, MS Rockville, MD, United States

Nikolajs Zeps, PhD Perth, WA, Australia

Sarah McCarthy, MSc, MBA Vancouver, BC, Canada

Membership and Marketing Advisory Committee Chair David Lewandowski Poway, CA, United States

9 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Isber Commitees 2013-2014 Executive Committee President: Fay Betsou President-Elect: Andy Zaayenga Past President: Katheryn Shea Secretary and Treasurer-Elect: Heather Siefers Treasurer: Cheryl Michels Transition Liaison: Marianne Henderson

Audit and Finance Committee

Governance Committee Chair Heather Siefers Members Cheryl Michels Katherine Sexton Katheryn Shea Nicole Sieffert

Scientific Program Advisory Committee

Chair Cheryl Michels

Co-Chairs

Members

Jodi Black Marianne Henderson

Fay Betsou Scott Jewell David Lewandowski Katheryn Shea Heather Siefers Andy Zaayenga

Members

Nominating Committee Chair Katheryn Shea Members Elaine Gunter Marianne Henderson Helen Morrin Alison Parry-Jones Peter H. J. Riegman Amelia W. Warner Fay Betsou

Jason Acker Kyung-Sook Ahn Paul Bartels Anna Beskow Marianna Bledsoe Koh Furuta Galen Hostetter Olga Kofanova Zisis Kozlakidis David Lewandowski Maimuna Mendy Piper Mullins Rebekah Rasooly Melissa Rawley Payne Kristen Rosati Katheryn Shea Sylvia Silver

Advisors Antonio Hugo Campos Karen Suzanne Meir Alison Parry-Jones Christina Schroeder Laura Weaver Andy Zaayenga Nik Zeps Ex Officio Fay Betsou Jane Carpenter Cheryl Michels Brent Schacter

Organizing Advisory Committee Chair Marianne Henderson

Education and Training Advisory Committee Co-Chairs Alexandra Lerch-Gaggl Nicole Sieffert Members Erica Benson Fay Betsou Jane Carpenter Debbie Garcia Judith Giri Kristina Hill Lise Matzke Lisa Miranda Sheila O’Donoghue Advisors Marianna Bledsoe Karen Pitt Katherine Sexton

Members Jodi Black Sheila O’Donohue Andy Pazahanick Brent Schacter Daniel Simeon-Dubach Menhong Sun Fay Betsou Cheryl Michels Heather Siefers Andy Zaayenga

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International Society for Biological and Environmental Repositories

Science Policy Advisory Committee Co-Chairs Tyron Hoover Nicole Sieffert Nikolajs Zeps Members Marianna Bledsoe Lisa Gilbert William Grizzle Paula Kim Yeonhee Lee Helen Moore Helen Morrin Amelia Warner Wendy Wolf

ISBER 2014 Scientific Program

Membership and Marketing Advisory Committee

Publications Advisory Committee Chair

Chair

Marianna Bledsoe

David Lewandowski

Members

Vice-Chair

Roger Aamodt Lori Campbell William E. Grizzle Elaine Gunter Scott Jewell Peter Riegman Brent Schacter Daniel Simeon-Dubach Peter Watson

Elaine Gunter Members Phil Baird Luke Bradshaw David Carpentieri Debra Garcia Marianne Henderson Rick Michels Alison Parry-Jones Heather Siefers Daniel Simeon-Dubach Jay Yakabowich Andy Zaayenga

Newsletter Editor-in-Chief Rick Michels

ISBER Working Groups • • • • • • • • • •

Biospecimen Science Environmental Biospecimens Hospital-Integrated Biorepositories Informatics Regulatory and Ethics Working Group (Formerly the Informed Consent Procedures for the Collection of Biospecimens) Integrated Biobanking Workflows International Repository Locator Rare Diseases Rights to and Control of Human Tissue Samples Trans-Omics

ISBER Special Interest Groups • •

Automated Repositories Management of Investigator-Returned Research Results

Vice-Chair and BIO Editor in Chief Jim Vaught

ISBER 2014 Award Winners ISBER Distinguished Leadership & Service Award

ISBER Special Service Award

This award is designed to honor ISBER members who have demonstrated exceptional leadership to further the mission and goals of the society and/or significant, long-standing contributions to the society.

The ISBER Special Service Awards recognize individuals who have made exceptional contributions towards the goals of the Society through the performance of a special service or act on behalf of the organization.

Rita Lawlor (Italy)

Peter Watson, MB, BChir FRCPC (Canada) Brent Schacter, MD, FRCPC (Canada)

ISBER Award for Outstanding Achievement in Biobanking

ISBER Travel Award

The ISBER Award for Outstanding Achievement in Biobanking, sponsored by Taylor-Wharton, is designed to recognize individuals who have made outstanding contributions to the field of biobanking.

The ISBER Global Expansion Fund supports efforts to increase ISBER’s membership and presence world-wide. The ISBER Travel Award provides travel support for individuals from emerging countries who are planning, or are currently managing, a repository to attend the ISBER Annual Meeting.

Yeonhee Lee, PhD (South Korea)

Sureyah Nassimbwa (Uganda)

11 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

General Information Venue

5K Fun Run/1M Walk/Sleep Walk

Walt Disney Dolphin Hotel 1500 Epcot Resorts Blvd, Lake Buena Vista, Florida 32830, United States Meeting Dates: May 20-24, 2014

• •

Registration

Pre-Conference Workshops (separate registration required):

Opening Hours: Tuesday, May 20 Wednesday, May 21 Thursday, May 22 Friday, May 23 Saturday, May 24

See page 36 for details.

06:45 – 17:30 07:00 – 18:00 07:00 – 18:00 07:00 – 18:00 07:00 – 13:00

Exhibit Hours: Wednesday, May 21 Thursday, May 22 Friday, May 23

10:30 – 18:30 09:30 – 18:00 09:30 – 16:00

Workshop Workshop 1A Workshop 1B Workshop 1C Workshop 2A Workshop 2B Workshop 2C Workshop 3A Workshop 3B Workshop 3C

Speaker Services (Pacific C): Tuesday, May 20 06:45 – 14:45 Wednesday, May 21 07:30 – 15:30 Thursday, May 22 08:00 – 16:00 Friday, May 23 08:00 – 16:00 Saturday, May 24 08:00 – 13:00

On-Site Rate

$72 $72 $72 $72 $72 $72 $125 $100 $100

ODD Numbered Posters

EVEN Numbered Posters

Poster Set up: Wednesday May 21 12:00 – 12:30

Poster Set up: Thursday May 22 15:30 – 16:00

Member

$925

$1,050

(onsite poster boards will provide the abstract number)

Non-Member

$1,225

$1,350

Technician

$675

$695

One Day Pass

$495

$495

Presentation: Thursday May 22 12:30 – 13:30

Full Conference Registration: •

Registration Fee (USD)

Poster Presentation Instructions

Annual Meeting Registration (Prices in USD)

Regular Rate

$30 USD Pre-Registration $40 USD On-Site Registration

Includes participation in all scientific sessions, delegate bag, refreshments during breaks, and Opening and Closing Ceremonies.

Presentation: Friday May 23 11:30 – 12:30

(all presenters must be by their posters during this time frame)

Posters Take Down: Thursday May 22 14:00 – 14:30

Posters Take Down: Friday May 23 18:00 – 18:30

(Posters that are not removed will be taken down)

Exhibit-only attendees: •

Access to the Exhibit Hall, conference meals served in the Exhibit Hall, and access to the Abstract Poster Networking Event.

Certificates of Attendance: •

Scan this code and download the Final Program directly to your phone or tablet.

All attendees will receive a certificate of attendance by email after the meeting.

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

Venue Map Meeting room

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escalators Main Meeting rooms & exhibit

Level -1 East Sidewalk Drive-Up Access

poster area Pacific Terrace

Pacific A Plenary

Pacific Hall B Exhibit Hall

Pacific C Concurrent

Atlantic Hall A

B

C

Escalators to Meeting Rooms

speaker services Pacific Hall Foyer Convention Entrance/Departure

Registration Atlantic Hall Foyer Desk

Atlantic Hall Foyer

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enter

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Exhibition Floor Plan

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program Exhibitors Exhibitor Company Airgas Artificial Intelligence in Medicine Inc. ASKION GmbH AstridBio Technologies Inc. AutoGen Inc. Autoscribe Limited Bahnson Environmental Specialties, LLC BASF / Metanomics Health BioCision BioFortis Biolife Solutions Biologix Group Limited BioMicroLab Biosero, LLC BioStorage Technologies Brady Corporation Brooks Life Science Systems BSI Systems / Information Management Services caTissue Plus chemagen from PerkinElmer, Inc. CloudLIMS Coldstash College of American Pathologists Computype Coriell Institute for Medical Research Cryoxtract Instruments Custom Biogenic Systems Denator AB DNA Genotek ELPRO Services Fisher BioServices Fluidigm Corporation Fluidx Ltd. Freezerworks Gas Cryo Systems Greiner Bio-One

Platinum Partners

Booth Number(s) 220 404 101 314 105 120a 303 112 113 213 215a 108 114 203 216 304 211, 310 307 419 317, 416 302 402 110 409a 411 107, 206 111 116 315a 200 405, 407 115a, 214a 410 202 118 205

Exhibitor Company Hamilton Storage Technologies HighRes Biosolutions IMV Technologies / Cryo Bio Systems ISENET-USA LLC Kairos GmbH KAYE LabVantage Solutions, Inc. Liconic Mayo Clinic Bioservices Mesa Labs Micronic MVE Chart NHLBI – BioLINCC. Pacific Bio-Material Management, Inc./ Novare Bio-Logistics Panasonic Praxair Precision Bioservices Promega Rees Scientific RUCDR Infinite Biologics Ruro, Inc. Scinomix Inc. Sequenom So-Low Environmental Equipment Co., Inc. Starlims Stirling Ultracold Taylor-Wharton Tecan Thermo Scientific Titian Software TTP Labtech TWD TradeWinds, Inc.

Vaisala, Inc Wheaton

Booth Number(s) 212 222 403 412 414 305 102 313 315 116a 104 201, 300 413 204 314a, 316 406 120 215 121 117 312 417 118a 106 103 415 301, 400 217 409 214 207, 306 115

414a 415a

Gold Partners 15 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Sign up for the 5K Fun Run/1M Walk/Sleep Walk Take part in the ISBER 5K Fun Run-walk or run at your own pace and help the ISBER Global Expansion Fund raise money for the ISBER Travel Award. Sign up online or at the registration desk on site. Thursday May 22, 06:30 – 07:30 Meeting Point: Dolphin Hotel Lobby, 06:00

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Interactive Discussions B

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The Interactive Discussions are composed of several focused roundtable discussions on topics submitted and coordinated by ISBER members. Sign up to participate in the discussion of your choice at the Registration Desk. Friday, May 22, 15:30 – 16:30 in Room Pacific C.

2014 Topics The Future of Sample Tracking Facilitator: Martin Frey

Building Collaborations Between Biorepositories and Digital Repositories: Research Challenges and Research Benefits Facilitator: James W. McNally

LMIC Discussion Group-ISBER 2014 Facilitator: Maimuna Mendy

Best Practices in Bioprocessing and Biobanking to Support Biomarker Development Facilitator: Kristina Robson

Secondary Use of Human FFPE Samples. Do’s & Don’t’s Facilitator: Chantal Steegers

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International Society for Biological and Environmental Repositories

Genomic solutions for biobanks. Start adding value today. Increase the return on your biobank specimen investment. Illumina has the tools, the experience, the support, the resources, and the collaborative spirit you need to do more, and do it more efficiently.

See how we can work together by meeting with Illumina during ISBER. Contact Alem Taye at +1.301.828.5500. Join our workshop: Illumina Biobank Solutions Tuesday, May 20 at 16:00

Taylor-Wharton Partners for Life

™

Submit this form at the link shown below with details on how you work to find a cure for Autism, and how this freezer could benefit the search for a cure.

http://partnersforlife.taylorwharton.com

ISBER 2014 Scientific Program

19 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

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International Society for Biological and Environmental Repositories

Fill it in and win! Win a Two-Night Stay at the Walt Disney Swan & Dolphin Resort

How to enter: Keep the Exhibitor’s Passport with you when you visit the Exhibit. Make sure that the Exhibitors stamp your passport as you visit their booths. Once you have completed the form, return it to the Registration Desk (You must have 55 stamps to be eligible). The draw will take place at the Business Meeting on Friday, May 23, 16:45 – 18:00.

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Pre-Conference Workshops Tuesday, May 20, 2014 06:45 – 17:30

Registration (Atlantic Hall Foyer)

07:00 – 13:00

Pre-Conference Workshops (separate registration required)

07:00 – 08:00

Coffee & Pastries (Europe Hall Foyer)

Time

07:00 – 08:30

Europe 9

Europe 10

Workshop 1A: “Fit for Purpose” Protocol Planning: A Tutorial to Facilitate Evidence Focused Biobanking Practice - in Real Time

Workshop 2A: Implementing Robust Quality Management Systems for Repositories

Facilitators: Lisa B. Miranda, Melissa Rawley-Payne, Helena Judge Ellis, Mark Bouzyk

08:30 – 08.45

08:45 – 10:45

Facilitators: Judith Giri, Elaine Gunter, Barbara Glazer, Phil Baird

Time

Europe 11 Workshop 3A: Part 1: Issues to Consider in Designing a Repository

07:00 – 09:30

Part 2: The Nuts and Bolts of Operating a Repository Facilitators: Katherine Sexton, William E. Grizzle

Coffee Break (Europe Hall Foyer) Workshop 1B: Surveys, Migration, and Changes – Informatic Considerations for Biobanks

Workshop 2B: Part 1: Biospecimen Science: Learning from Cryobiology to Improve Preservation Outcome

Facilitators: Kevin Meagher, Piper Mullins, Ashok Patel, Mark Cada

Facilitators: Rebecca Spindler, Mark Cosentino, Erik Woods

Part 2: Keep Your Samples Safe: Choose the Appropriate Storage Container

09:30 – 09:45

Coffee Break (Europe Hall Foyer) Workshop 3B: Essential Concepts for Effective Specimen Receipt Facilitators: Karen Pitt, Rebecca Pugh

09:45 – 11:15

(Part of the educational requirements of the ISBER Certified Repository Technician program)

11:15 – 11:30

Coffee Break (Europe Hall Foyer)

Facilitator: Alexandra Lerch-Gaggl

10:45 – 11:00

11:00 – 12:30

Coffee Break (Europe Hall Foyer) Workshop 1C: Are You Prepared? Case Studies in Balancing Biospecimen-related Patient and Investigator Requests with Risk Management and Human Subjects Protections in the Age of Genomic Medicine

Workshop 2C: Limitations in the Use of Human and Animal Tissues in Research: What Biorepositories and Investigators Need to Know Facilitators: William E. Grizzle

Workshop 3C: Creating Successful Training Programs for Repository Staff 11:30 – 13:00

Facilitators: Marianna Bledsoe, Mary E. Edgerton, Ty Hoover, Nicole Sieffert

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International Society for Biological and Environmental Repositories

Facilitators: Karen Pitt, Alexandra Lerch-Gaggl (Part of the educational requirements of the ISBER Certified Repository Technician program)

ISBER 2014 Scientific Program

13:30 – 18:15 Time

13:30 – 14:30

Corporate Workshops Europe 9

Europe 10

Europe 11

Workshop 1A Bytes and Biospecimens: Transforming your Biobank into a Knowledge-Base for Personalized Medicine

Workshop 2A Successful Implementation of Automation in Biobanks

Workshop 3A Towards Successful Collaborative Translational Research through Biobanking: Considerations for Managing Sample Temperature and Pre-analytical Variability

Tecan US, Inc.

Biofortis

Fisher BioServices

14:30 – 14:45

Coffee Break (Europe Hall Foyer) Workshop 3B Heat Stabilization Maintains Sample Integrity in Collection and Processing for Biobanking Denator AB

14:45 – 15:45

15:45 – 16:00

Coffee Break (Europe Hall Foyer) Workshop 1C Using Automated Storage to Meet Repository Objectives

16:00 – 17:00

17:00 – 17:15

Workshop 2C Biobank Solutions Illumina

Brooks Automation

Workshop 3C Protecting Your Biological Assets and Your Budget: Novel Strategies for Sample Archival and Quality Assurance Biomatrica

Coffee Break (Europe Hall Foyer) Workshop 1D Managing the Past for the Future

Workshop 2D Panasonic

TTP Labtech & CryoXtract

Workshop 3D ISBER Best Practices & Storage Options Taylor-Wharton

17:15 – 18:15

17:30 – 19:00

Biopreservation and Biobanking Editorial Board Meeting (Invitation Only) Oceanic 4

19:00 – 21:00

Reception for Chinese Delegates (Open to all delegates from China) Sponsored by Taylor-Wharton Australia 2

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Scientific Program Wednesday, May 21, 2014 07:00 – 18:00

Registration (Atlantic Hall Foyer)

07:00 – 08:00

Coffee & Pastries (Pacific A)

07:00 – 08:00

Working Group Meetings

Time 07:00 – 08:00

08:00 – 09:00

Europe 9

Europe 10

Europe 11

Biospecimen Science Working Group (Invitation Only)

Environmental Biospecimens Working Group (Open to all Participants)

Hospital-Integrated Biorepositories Working Group (Open to all Participants)

Getting to Know ISBER Meet and Greet for new and prospective ISBER members. All meeting participants welcome and encouraged to attend. Chairpersons: Kathi Shea (USA), Elaine Gunter (USA)

Pacific A Symposium 1 • Advancing Science Through Evidence-Based Biobanking Chairpersons: Jodi Black (USA), Marianne Henderson (USA)

This symposium will focus on how high-quality samples, data and research support evidence-based discoveries in both global and environmental health, and inform evidence based best practices in biobanking. Pacific A 09:30 – 12:30

09:30 – 09:45

Welcome and Opening Remarks • Fay Betsou (Luxembourg) ISBER President, 2013-2014

09:45 – 10:30

Keynote Speaker: Integration of Biobanks into Clinical Health Care through Linkage to Medical Records—The eMERGE Experience • Rex Chisholm (USA)

10:30 – 11:00

The Australian Plant Bank – Safeguarding Plants for the Future • John Siemon (Australia)

11:00 – 11:30

Coffee Break in Exhibit Hall

11:30 – 12:00

Geisinger’s MyCode Project: Leveraging Genomics and EMR Data to Improve Patient Outcomes • David Ledbetter (USA)

12:00 – 12:30

Cell Processing and Preservation for Biobanking: New Horizons • Erik Woods (USA)

12:30 – 14:00

General Lunch with Exhibits

12:30 – 13:30

Working Group / Advisory Committee Meetings

Time 12:30 – 13:30

Europe 9

Europe 10

Europe 11

Science Policy Committee (Invitation Only)

Rare Diseases Working Group (Open to all Participants)

Membership & Marketing Committee (Invitation Only)

Symposium 2 • Translational Science through Biobanking: Applications and Opportunities Chairpersons: Zisis Kozlakidis (UK), Brent Schacter (Canada)

Translational research is necessary to find practical, research-based answers to important questions. It creates both new opportunities for further research and provides innovative feedback on relevant and critical issues in order to improve biobanking practices. This symposium will focus on practical solutions utilizing translational research approaches in many diverse fields in biobanking. 14:00 – 16:30

Pacific A 14:00 – 14:30

Clonal Evolution and Breast Cancer Subtypes • Sam Aparicio (Canada)

14:30 – 15:00

Enabling Personalized Discovery and Translation • Hakim Djaballah (USA)

15:00 – 15:30

Translational Applications of Biobanking: The Fibroblast Growth Factor 23 Story • Myles Wolf (USA)

15:30 – 16:00

China National GeneBank, Making the Resource Valuable to Everyone • Yong Zhang (China)

16:00 – 16:30

China Biobanking Strategy for Integrated Translational Research • Rongxing Gan (China)

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program 16:30 – 18:30

Welcome Reception Join us for an opportunity to network with attendees and exhibitors! Odd numbered posters will be on display. Exhibit Hall

18:30 – 19:30 Time 18:30 – 19:30

Working Group / Advisory Committee Meetings Europe 9

Europe 10

Europe 11

Oceanic 4

Publications Committee (Invitation Only)

Education & Training Committee (Invitation Only)

Rights to and Control of Human Tissue Samples Working Group (Open to all Participants)

Integrated Biobanking Workflows Working Group (Open to all Participants)

Thursday, May 22, 2014 07:00 – 18:00

Registration (Atlantic Hall Foyer)

06:30 – 07:30

ISBER 5K Fun Run/1M Walk/Sleep Walk (Separate Registration Required) Meeting point: Dolphin Lobby 06:00 Walk or run at your own pace and help the ISBER Global Expansion Fund raise money for the 2015 ISBER Travel Award.

07:30 – 08:30

Coffee & Pastries (Pacific A) Symposium 3A (Concurrent Session) Financial Sustainability of Biobanks Chairpersons: Marianne Henderson (USA), Daniel Simeon-Dubach (Switzerland)

Financial sustainability in biobanking: moving past models to real world experiences in biobanks ranging from country-wide and regional networks, to large medical centers, to non-profit, to government. This session will be an INTERACTIVE AUDIENCE SESSION. Be early to get a keypad to register your views during this informative discussion. Support for the use of the audience participation toolset was generously sponsored by Dataworks Development. Biobanking is a key component of personalized medicine. The complexity of biobanking is increasing with the demands to improve specimen and data quality, scientific methodology, safety, operations, ethical and legal infrastructure. These improvements escalate the cost of the biobanking business across the continuum. Long term financial sustainability must be maintained to maximize the benefit of biobanking to global health. The need to sustain biobanking to support global health is a challenge of buy-in of all stakeholders; financial support from many different sources; and risk management. This interactive session will provide views from several biobanking experts and their in-process approach to sustainable operations. Pacific A 08:30 – 11:30

08:30 – 08:40

Overview Marianne Henderson (USA), Daniel Simeon-Dubach (Switzerland)

08:40 – 08:55

Peter Watson (Canada)

08:55 – 09:10

Brent Schacter (Canada)

09:10 – 09:25

Rusty Bromley (USA)

09:25 – 09:40

Brian Thomson (UK)

09:40 – 09:55

Peter Riegman (Netherlands)

09:55 – 10:30

Coffee Break in Exhibit Hall

10:30 – 10:45

Jan-Eric Litton (Sweden)

Panel Discussion with Audience Participation 10:45 – 11:30

Panel: Peter Watson (Canada), Brent Schacter (Canada), Rusty Bromley (Canada), Brian Thomson (UK), Peter Riegman (Netherlands), Jan-Eric Litton (Austria), Jim Vaught (USA), Balwir Matharoo-Ball (UK)

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Symposium 3B (Concurrent Session) Model Organisms and Biodiverse Biorepositories: Interdisciplinary Perspectives in Biobanking (Joint Session with the Society for Cryobiology) Chairpersons: Piper Mullins (USA), Paul Bartels (South Africa)

Research on model organisms and diverse species enhances knowledge of fundamental biological properties for biodiversity conservation, biotechnology development and human health. This symposium will focus on environmental and biological biobanks and how their operations contribute to interdisciplinary applications across biobanks. Pacific C 08:30 – 09:00

From Concept to Application: Developing a Functional DNA and Germplasm Repository for Animal Genetic Resources Harvey Blackburn (USA)

08:30 – 11:30 09:00 – 09:30

The Ins and Outs of a Living Bank: Prioritisation, Viable Populations and Continual Access Rebecca Spindler (Australia)

09:30 – 10:00

Keeping Clear of the Lions Mouth – Establishing & Scaling-up a Biodiversity Biobank for Southern Africa Paul Bartels (South Africa)

10:00 – 10:30

Coffee Break in Exhibit Hall

10:30 – 11:00 11:00 – 11:30

The International Environmental Specimen Bank (IESB) Group Paul Becker (USA)

The Endangered Species Challenge: Making Use of Opportunistic Sampling Erin Ehmke (USA)

Innovative Technologies Chairs: Andy Zaayenga (USA), David Lewandowski (USA)

The Innovative Technologies session is a unique opportunity for companies to highlight the science and validation behind new products and technologies that have the potential to impact biorepository operations and specimen management/workflow. Pacific A 11:30 – 11:35 11:35 – 11:45

Welcome Tissue Microarray Technology: New Opportunity for Tissue Banks to Contribute to Cancer Research and Diagnostics Pasquale De Blasio (USA)

11:30 – 12:30

11:45 – 11:55

New Metabolic Assay for Pre-Analytical Quality Control of Human Plasma Samples Beate Kamlage (Germany)

11:55 – 12:05

The Fluidigm® SNPtrace™ Panel and the BioMark™ System Enable Fast, Efficient, and Cost-Effective Sample Assessment with Minimal Hands-On Time Marie Lee (USA)

12:00 – 12:15

Technologies to Fully Automate Biological Vapor-Phase Nitrogen Repositories Below -100°C Lutz Doms (Germany)

12:15 – 12:25

Rapid Heat Stabilization of Enzymes is Essential for Accurate Measurement of Tissue Sample Analytes without Interference from Post-Mortem Events Charlotta Göransson (Sweden)

12:25 – 12:30 12:30 – 14:00

Closing Remarks

General Lunch with Exhibits and Posters • Odd Numbered posters will be on display. Working Groups Meetings / Advisory Committee Meetings

12:30 – 13:30

Europe 9

Europe 10

Europe 11

Biospecimen Science Working Group (Open to all Participants)

Proficiency Testing Advisory Group (Invitation Only)

Management of Investigator-Returned Research Results Special Interest Group (Open to all Participants)

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

Contributed Paper Session 1 (Concurrent Sessions) Specimen Quality: Do you Know What you are Really Working With? Chairs: Jane Carpenter (Australia), Galen Hostetter (USA)

Pacific A 14:00 – 14:15

14:15 – 14:30

The Effect of Blood Shipping on the Survival and Functionality of PBMCs

Contributed Paper Session 2 (Concurrent Sessions) ELSI for Biobanking – Is the Tail Wagging the Dog? Chairpersons: Sylvia Silver (USA), Rebekah Rasooly (USA)

Pacific C 14:00 – 14:15

Anita Posevitz-Fejfár (Germany)

Maui Hudson (New Zealand)

Developing Mouse Hospital with Human Patient Derived Xenograft Cancer Models – A Live Tumor Banking Approach

Future Use Considerations for Global Collections of Human Biospecimens: Annotation to Ensure Compliance in an Evolving Global Regulatory Environment

14:15 – 14:30

Vinagolu Rajasekhar (USA)

14:30 – 14:45

Katheryn Shea (USA)

Biobanking of Human Kidney Cancer Tissue: Impact of Ex-Vivo Ischemia Time and Storage Time on RNA Quality

14:30 – 14:45

Xianling Cong (China)

14:00 –16:00 14:45 – 15:00

Next Generation BioSpecimen Sciences at University Health Network – Canada’s Largest Hospital-Based Research Program

14:45 – 15:00

Tissue Modeling of RNA Degradation: MultiModality Measures and Biological Pathway Correlates

15:30 – 15:45

Gene Expression Assay to Assess the Pre-Centrifugation Delay of PBMCs

15:00 – 15:15

16:00 – 18:00

Genetic Knowledge and Return of Results Preferences in the Mayo Clinic Biobank Janet Olson (USA)

15:15 – 15:30

Omics-Ready Bio/Data Repository For Childhood Cancers in Egypt

Olga Kofanova (Luxembourg)

Rania Labib (Egypt)

Storage Stability of Metabolic Diseases Biomarkers in Urine

Role of the Genetic Counselor in a NonDisease Focused Biobank: Experience of the Mayo Clinic Biobank

15:30 – 15:45

Yinan Zhang (China)

15:45 – 16:00

EU Data Protection Regulation and Transatlantic Datasharing Evert-Ben van Veen (The Netherlands)

Galen Hostetter (USA)

15:15 – 15:30

Senior Biobank Staff and Genetic Researchers’ Opinions about Human Subjects Practices in Genomic Research Rachel Dvoskin (USA)

Michael Roehrl (Canada)

15:00 – 15:15

Developing Best Practice Biobanking with Indigenous Peoples

Erin Winkler (USA)

Discussion

15:45 – 16:00

Discussion

Exhibitor and Poster Networking Evening Join us for a networking event to visit the exhibits and posters! Even numbered Posters will be on display.

Friday, May 23, 2014 07:00 – 18:00 07:00 – 07:30

Registration (Atlantic Hall Foyer) Vendor Meeting (All exhibitors are encouraged to particpate) Facilitator: David Lewandowski

Australia 3 07:30 – 08:30

Coffee & Pastries (Pacific A) Working Group Meetings

07:30 – 08:30

Europe 9

Europe 10

Europe 11

Informatics Working Group (Open to all Participants)

Regulatory and Ethics Working Group (Open to all Participants)

International Repository Locator Working Group (Open to all Participants)

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Symposium 4 • Biospecimen Science (Joint Session with the Society for Cryobiology) Chairpersons: Olga Kofanova (Luxembourg), Jason Acker (Canada) This symposium will introduce new discoveries and challenges of biospecimen science and raise awareness of issues influencing sample integrity related to different biopreservation steps, including freezing and storage. The goal of this symposium will be to cover pre-analytical aspects in handling and analysis of specimens, and the application of cryobiological principles to the successful preservation of biospecimens and biological resources. Pacific A 08:30 – 11:30

11:30 – 13:00

08:30 –09:00

Controlled Analysis of Pre-Analytical Variables in CSF 2 Blood Sample Collection, Processing & Storage: Implications for Best Practices in Clinical Research • Mimi Roy (USA)

09:00 – 09:30

Scientific Basis for Selection of a Storage Temperature • Alison Hubel (USA)

09:30 – 10:00

Markers of Biobank Sample Quality • Rainer Lehman (Germany)

10:00 – 10:30

Coffee Break in Exhibit Hall

10:30 – 11:00

The Science of Freezing Blood Cells • Jason Acker (Canada)

11:00 – 11:30

Understanding Biospecimen Sample Integrity Using Molecular and Proteomic Biomarkers • Lokesh Agrawal (USA)

General Lunch with Exhibits and Posters • Even numbered Posters will be on display. Contributed Paper Session 3 (Concurrent Sessions) It’s a Small World: Are We Preserving It?

Contributed Paper Session 4 (Concurrent Sessions) Through the Looking Glass: Hot Topics in Biobanking

Chairs: Koh Furuta (Japan), Heather Siefers (USA)

Chairs: Zisis Kozlakidis (UK), Maimuna Mendy (France)

Pacific A

Pacific C

13:00 – 13:15

13:15 – 13:30

Organization of the Seed Bank in the Permafrost Soils of the Yakutia

13:00 – 13:15

Efim Khlebnyy (Russia)

Karine Sargsyan (Austria)

Influence of Permafrost on Allium Fistulosum Seeds Preservation

Using the Biomaterial of the Radiobiological Human Tissue Repository for Solving the Problems of Radiobiology

13:15 – 13:30

Ilya Prokopiev (Russia)

13:30 – 13:45

13:00 – 15:00

13:45 – 14:00

Biobank Graz: Accumulative Hub of Biobanking Networks in Europe

Biobank Construction after Earthquake and Tsunami Disaster in Japan

Evgeniya Kirillova (Russia)

13:30 – 13:45

The Value of Large Scale Biobanking in Clinical Healthcare

Naoko Minegishi (Japan)

Gyorgy Marko-Varga (Sweden)

China National GeneBank (CNGB) Status Quo as of the End of 2013

The Great Lakes Biorepository Research Network (GLBRN) – An Inter-Institutional Collaborative Effort to Improve the Management of Biospecimen Collections and Subsequent Translational Research

13:45 – 14:00

Tina Yeung (China)

Jan Akervall (USA)

14:00 – 14:15

Towards the Use of Mobile Lab Technologies for the Collection of Human Samples of the German Environmental Specimen Bank

The Dutch National Tissuebank Portal. One Portal to All Pathology Archives 14:00 – 14:15

Chantal Steegers (The Netherlands)

Dominik Lermen (Germany)

14:15 – 14:30

Marine Environmental Specimen Bank Barcode Implementation System

14:15 – 14:30

Amanda Moors (USA)

Dynamic Map-Based Visualization Tools for Complex Inventory/Freezer Management: Open Source Informatics Developed by NHLBI BioLINCC Elizabeth Wagner (USA)

14:30 – 14:45

Discussion

14:30 – 14:45

Financial Sustainability in Biobanking is a Myth Monique Albert (Canada)

14:45 – 15:00 15:00 – 15:30

Coffee Break in Exhibit Hall

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International Society for Biological and Environmental Repositories

Discussion

ISBER 2014 Scientific Program

Special Topic Session (Concurrent Sessions) Important Biobanking Developments in Europe Chairpersons: Fay Betsou (Luxembourg), Rita Lawlor (Italy)

Interactive Discussions All the discussions take place concurrently. Pacific C

Pacific A 15:30 – 15:40 15:40 – 16:10 15:30 – 16:30

Introduction

The Future of Sample Tracking

Fay Betsou (Luxembourg) & Rita Lawlor (Italy)

Facilitator: Martin Frey (USA)

BBMRI-ERIC, a New Governance Tool for Biobanking

Building Collaborations Between Biorepositories and Digital Repositories: Research Challenges and Research Benefits

Jan-Eric Litton (Sweden)

16:10 – 16:30

Facilitator: James W. McNally (USA)

The Finnish Law on Biobanks and the EU General Data Protection Regulation Proposal: How to Compose Different Approaches within the European Ethical Landscape?

LMIC Discussion Group-ISBER 14

Elena Salvaterra (Italy)

Best Practices in Bioprocessing and Biobanking to Support Biomarker Development

Facilitator: Maimuna Mendy (France)

Secondary Use of Human FFPE Samples. Do’s & Don’t’s Facilitator: Chantal Steegers (The Netherlands)

Facilitator: Kristina Robson (USA)

16:45 – 18:00

ISBER Business Meeting and Awards Presentation Join us to learn more about ISBER’s activities, financials, strategic plan and leadership Pacific A

18:30 – 19:30 Time 18:30 – 19:30

Working Group / Advisory Committee Meetings Europe 9

Europe 10

Europe 11

Trans-Omics Working Group (Open to all Participants)

Automated Repositories Working Group (Open to all Participants)

Governance Committee (Invitation Only)

Saturday, May 24, 2014 07:00 – 13:00

Registration (Atlantic Hall Foyer)

07:30 – 08:30

Coffee & Pastries (Pacific A & B) 2014 Education & Training Workshops

08:30 – 09:30

Hell or High Water: The Alberta Cancer Research Biorepository Disaster Readiness, Response and Recovery (Workshop 1A) Facilitators: Nigel Brockton (Canada), Charlene Karvonen (Canada)

Pacific A Informed Consent for Genomics: Policies, Problems and Practical Approaches (Workshop 1B) 08:30 – 09:30

Facilitators: Marianna Bledsoe (USA), Amelia Warner (USA), Anita Nelsen (USA)

Pacific C 09:30 – 09:45

Coffee Break Weathering the Storm: Assessing Business Continuity Measures in Biorepository Operations (Workshop 2A)

09:45 – 10:45

Facilitators: Kristina Robson (USA), Andrew Brooks (USA)

Pacific A ELSI Challenges in Biobanking & Genomics Research (Workshop 2B) 09:45 – 10:45

Facilitators: Pedro Rondot Radío (Argentina), Rosario Isasi (Canada), Anne-Marie Tassé (Canada)

Pacific C 10:45 – 11:00

Coffee Break (Pacific A)

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Symposium 5 • Biospecimen Identifiability, Privacy and Broad Data Sharing Chairpersons: Marianna Bledsoe (USA) and Kristen B. Rosati (USA)

A number of recent studies have raised questions about the identifiability of “de-identified” genomic data and specimens and about how best to protect the privacy of participants and the confidentiality of their data. At the same time, broad sharing of genomic information and individuallevel data is not only being encouraged but, in some cases, required. The tension between the need to protect privacy and the need to share data broadly to facilitate scientific and medical advances raises a number of policy challenges. This symposium will explore these issues and ways they might best be addressed through policy and law. Pacific A 11:00 – 13:00

11:00 – 11:20

Assessing and Mitigating Risk of Identifiability Brad Malin (USA)

11:20 – 11:40

Recent EMA Regulations Mandating Clinical Trials Data Sharing Mark Barnes (USA)

11:40 – 12:00

Building an International Code of Conduct for Genomic and Health-Related Data Sharing Anne-Marie Tassé (Canada)

12:00 – 13:00

Panel Discussion Panel: Tim Shi (China), Tohru Masui (Japan), Brad Malin (USA), Mark Barnes (USA), Anne-Marie Tassé (Canada), Evert-Ben van Veen (The Netherlands), Helen Morrin (New Zealand), Amelia Warner (USA)

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program Speaker Summaries The Science of Freezing Blood Cells Jason Acker MBA, PhD, Canadian Blood Services, Edmonton, Canada

Cryopreservation of cells is an integral function of cell processing laboratories and biorepositories. Yet many who routinely perform cell cryopreservation have limited knowledge about cryobiology, the mechanism of action of cryoprotective agents, the impact of cryoinjury on post-thaw cell quality measures, and the impact that damaged and dead cells can have on patients upon infusion. This presentation will be focused on the cryopreservation fundamentals and their influence on common practices as well as quality control aspects of the freezing process and the biophysics of transient warming events. The cryopreservation of human blood cells will be used to illustrate the multiple factors that need to be considered when developing cryopreservation protocols for cellular therapeutics or archived cellular materials.

Understanding Biospecimen Sample Integrity Using Molecular and Proteomic Biomarkers Lokesh Agrawal, PhD, Biorepositories and Biospecimen Research Branch, DCTD, National Cancer Institute, Rockville, USA

The talk will summarize research projects sponsored by the NCI Biospecimen Research Network (BRN) to develop assays and identify biomarkers that may be used as sentinel markers of plasma and tissue stability in biobanks using mass-spectroscopy proteomics, analysis of circulating miRNA, and development of intrinsic controls for FFPE tissues. Protein biomarkers for assessing sample integrity in plasma will be discussed followed by a second project looking at the effects of pre-analytical variables on circulating miRNA for identification and validation of new housekeeping. Another study will describe a series of biomarkers identified and validated using construction of tissue microarray (TMA) and tissue quality index (TQI). New projects that involve comparison of proteome in plasma and PBMCs taken from patients before and after administration of general anesthetic, and stability of phosphoproteins in colon tumor and normal adjacent tissues with respect to processing and surgical manipulation will also be discussed. Overall this presentation will outline the progressive efforts taken by BRN-sponsored projects to define the impact of key pre-analytical variables in human biospecimens and to develop innovative approaches for assessment of biospecimen quality.

Clonal Evolution and Breast Cancer Subtypes Sam Aparicio BM, BCh, PhD, FRCPath, BC Cancer Agency, Vancouver, Canada

The notion that most cancers are ecosystems of evolving clones has implications for biological understanding and clinical application. The evolution of clonal composition has particular significance when evidence of positive or negative selection can be associated with the clonal genotype or epigenotype. I will discuss the implications of clonal evolution for cancer medicine, with reference to breast cancer subtypes. We have developed informatics approaches to population-level clonal analysis and extended these to single cell genotypes. Our more recent data on clonal evolution of patient-derived tumour xenografts illustrates the impact of clonal evolution on biological studies of cancer.

Recent EMA Regulations Mandating Clinical Trials Data Sharing Mark Barnes, J.D., Ropes & Grey, Boston, USA

EMA has recently begun to require that patient-level data collected in the course of clinical trials and that support any successful marketing application submitted to EMA must be made available in an anonymized form to independent researchers. Meanwhile, the EU has also tightened its various privacy regulations, which seems, in spirit if not in law, to be inconsistent with EMA’s push for data transparency. This session will explore EMA’s regulations and the latest developments in EU privacy law, to understand these requirements, and how they relate to clinical trials in North America and around the world.

The International Environmental Specimen Bank (IESB) Group Paul Becker, Chemical Sciences Division, National Institute of Standards & Technology, Charleston, United States

Environmental specimen banking has been recognized worldwide as an important component to real time environmental monitoring, such as environmental contaminants. Since the 1960’s scientists have been collecting and archiving environmental specimens (i.e. biological tissue, sediment, seeds, ice cores, etc.) for these types of analytical analyses. The International Environmental Specimen Bank (IESB) Group has been exchanging data, protocols, and strategies of environmental specimen banking for over 30 years. The IESB Group will be described in more detail, including approaches being considered for enhancing international cooperation and the potential relationship between it and ISBER.

From Concept to Application: Developing a Functional DNA and Germplasm Repository for Animal Genetic Resources Harvey Blackburn, PhD, USDA/ ARS/ National Animal Germplasm Program, Fort Collins, USA

In 1999 USDA’s Agricultural Research Service initiated the development of the National Animal Germplasm Program for the protection and increased utilization of livestock genetic resources. The primary mechanism to accomplish this goal has been the development of cryopreserved collections of germplasm and tissue from all major livestock and aquatic species. Since its inception this program has released over 15,000 samples to the public and private sector for animal regeneration or genomic studies. The current status and future development of this collection will be the subject of the presentation.

Integration of Biobanks into Clinical Health Care through Linkage to Medical Records—The eMERGE Experience Rex Chisholm, PhD, Northwestern University, Chicago, USA

The NUgene biobank links consented participants DNA samples with the totality of clinical information collected from their electronic health records sources obtained during routine clinical care. This resource is being used in discovery projects to identify novel gene/variant associations with disease susceptibility and the outcomes of therapies. This presentation will describe the experience of NUgene and the eMERGE consortium in both discovery and

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2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

in the implementation of genomic medicine through association of genetic variation with the clinical record, development of clinical decision support and assessment of the outcomes.

Enabling Personalized Discovery and Translation Hakim Djaballah, PhD, Director, Memorial Sloan-Kettering Cancer Center, New York, USA

One of the biggest challenges in treating cancer patients today is, and will be, the choice of drug regimen to administer and its consequences on disease remission and/or relapse. Advances in screening technologies combined with rapid purification and characterization of primary patient cancer cells, though very amenable to hematopoietic malignancies, would permit drug assessment prior to treatment in a precision strategy lineup of regimens. I will present and discuss the strategy and its use in the clinic.

The Endangered Species Challenge: Making Use of Opportunistic Sampling Erin Ehmke, PhD, Duke Lemur Center, USA

How can endangered species be utilized by the research community and, in particular, the biomedical field? The Duke Lemur Center (DLC) present a case study demonstrating the utility of the opportunistically banked samples inventory and associated database information, highlighting the solid foundation on which a wide variety of future biological studies can be built.

medicine led to creation of the MyCode biobank in 2006 to enable longitudinal, genomic medicine translational research. Strengths of MyCode include a stable population, multi-generational families, a single, dominant healthcare provider system, searchable medical data from ~20 years of EHR, and a participant consent rate of >90%. Recent enhancements to the MyCode consent and protocol to enable whole exome sequencing of 100,000 participants and the return of clinically actionable findings to participants will be discussed.

Markers of Biobank Sample Quality Rainer Lehmann PhD, University of Tübingen, Tübingen, Germany

The number of biobanks storing human body fluids is rapidly increasing world wide. This offers promising perspectives for large-scale epidemiological studies of common diseases to develop novel prevention and/or treatment strategies. Great efforts are undertaken to generate high quality samples. But accidental as well as systematic pre-analytical errors in the sample processing can not be excluded, even under very strictly controlled conditions. However, up to the present there is no way to assess the quality of blood samples stored in a biobank. In this talk, robust biomarkers of biobank blood sample quality, identified by a pseudotargeted metabolomics approach, are presented. The changes of the plasma concentration of these biomarkers in extreme (patho)physiological situations, like reanimation, hepatic failure, exhaustive exercise are also demonstrated. In addition, common pre-analytical pitfalls potentially affecting the outcome of large-scale epidemiological studies, and how to avoid these, will be discussed.

China Biobanking Strategy for Integrated Translational Research

BBMRI-ERIC, a New Governance Tool for Biobanking

Rongxing Gan, MD, Shanghai Clinical Research Center, Shanghai, China

Jan-Eric Litton, MD, Director General, BBMRI-ERIC, Stockholm, Sweden

As precious resource for both basic and clinical research, biobanks are the basis of translational research. High quality biosamples and data are crucial for biobanking. With the rapid development of biobanking in the past years, it has been the priority for health research in China. China National Biobank initiative has been planned for developing a nation-wide network of biobanks with unified standards and an information sharing system for the clinical resource database with focus on high quality biosamples and data, which will better serve new drug development and translational research in the future. The China Biobanking Strategy has drawn up the roadmap and provides suggestions for the development of biobanking in China.

On December 3rd, 2013, BBMRI was officially awarded the Community legal framework for a European Research Infrastructure Consortium (ERIC). This specific legal form is designed to facilitate the joint establishment and operation of research infrastructures of European interest. The ERIC status allows pulling together biobanks and biomolecular resources into a pan-European facility. BBMRI-ERIC will provide access to the collections of partner biobanks and biomolecular resources, their expertise and services on a non-economic basis.

Scientific Basis for Selection of a Storage Temperature Allison Hubel, PhD, University of Minnesota, Minneapolis, USA

The stability of a biospecimen is strongly influenced by storage conditions. This talk will describe the manner by which freezing conditions, solution composition and deactivation of degradative molecules influence selection of storage temperature. In addition, the scientific literature relevant to biospecimen storage will also be reviewed.

Geisinger’s MyCode Project: Leveraging Genomics and EMR Data to Improve Patient Outcomes David Ledbetter, PhD, Geisinger Health System, Danville, USA

Geisinger is a “Learning Healthcare Laboratory” dedicated to improving patient outcomes while reducing total cost of care. A commitment to personalized

Within the platform, research groups can develop functional standards for technical, legal and ethical purposes, set up criteria for biobanks, and so on. The ERIC also creates a platform for the involved researchers to communicate with policymakers in the EU and the Member States. BBMRI-ERIC will be a distributed infrastructure. Austria, Belgium, Czech Republic, Estonia, France, Germany, Finland, Greece, Italy, Malta, the Netherlands and Sweden are members of BBMRI-ERIC. Observers are Switzerland, Norway, Poland, Turkey and IARC (International Agency for Research on Cancer). The Office will be based in Graz, Austria with Prof. Jan-Eric Litton as the Director General.

Assessing and Mitigating Risk of Identifiability Brad Malin, PhD, Vanderbilt University, Nashville, USA

This presentation will review how biospecimens, and the data associated with them, can be compromised to ascertain the identity of the individuals to which they correspond. It will then review the difference between what is possible versus what is probable and how risk of identification can be formally assessed.

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This presentation will conclude with a discussion on how such risk can be mitigated using a combination of social and technical controls, with examples drawn upon several biorepositories the speaker has been involved with.

Controlled Analysis of Pre-Analytical Variables in CSF 2 Blood Sample Collection, Processing & Storage: Implications for Best Practices in Clinical Research Mimi Roy, PhD, Caprion Proteomics, Menlo Park, USA

Biological sample collection, processing and storage protocols are based on accepted practices rather than careful testing. We set out to examine variables intrinsic to each step in obtaining and storing clinical samples, beginning with collection in controlled studies. Blood and plasma/serum samples were compared before and after centrifugation. Various blood collection tubes, times on bench, incubation temperatures, freeze-thaw cycles and freezer storage effects over 18 months were compared. Independent studies have verified that these proteins indeed are markers of sample integrity. The results provide extensive information on pre-analytical variables and clear guidelines for sample handling for proteomic analysis.

The Finnish Law on Biobanks and the EU General Data Protection Regulation Proposal: How to Compose Different Approaches within the European Ethical Landscape? Elena Salvaterra J.D., PhD, Unit of Bioethics, Scientific Institute E. Medea, Italy

This talk aims to summarize interesting aspects of the European ethical landscape governing human biobanks. By focusing on relevant elements of the new Finnish Law on biobanks and the proposal of a European Regulation on General Data Protection, it seeks to give a picture of the variable regulatory realm characterizing the Europe at present. Whereas the Finnish Law on biobanks supports an ethically “open” approach to the research using human biological materials, by authorizing an “opt-out” consent model, the proposal of a harmonized European regulation on General Data Protection tends to sustain restrictive measures to protect the privacy of data subjects in several fields of life, including the scientific research environment. How to interpret this “fluidity” and compose this variable regulatory landscape in and out of Europe is the basic question of this presentation open to all the stakeholders involved in biobank based research.

The Australian Plant Bank – Safeguarding Plants for the Future John Siemon, BSc, The Royal Botanic Gardens & Domain Trust, Mount Annon, Australia

Australia is home to 25,000 known species of plants, 80% endemic, but sadly 1,700 plant species and communities are threatened and at the brink of extinction. The Royal Botanic Gardens Sydney is applying transdisciplinary conservation solutions to conserve species through the Australian PlantBank. PlantBank currently stores 25 percent of Australia’s flora in seed form as well as living collections such as tissue cultures and orchid mycorrhizal fungi. In the future, PlantBank will also house collections of fern spores and other potential regenerative entities. As a national repository PlantBank will one day research and store Australia’s entire native flora with capacity for collections from the Asia-Pacific region.

The Ins and Outs of a Living Bank: Prioritisation, Viable Populations and Continual Access Rebecca Spindler, PhD, Research and Conservation, Taronga Conservation Society, Sydney, Australia

The traditional concept of a static biobank that stores genetic material as insurance against a catastrophe is out-dated and must be reviewed. We are in the 6th global major extinction event, we are losing species at unprecedented rates and few catastrophes were recognised. Our skills, research focus and resources must now be targeted to capture viable genetic material from priority species, incorporating minimum population sizes, availability of material for research and novel techniques such as accelerated evolution. The potential outcomes of strategic genome resource banks include: 1) preservation of gene diversity; 2) avoiding natural loss of heterozygosity due to genetic drift in shrinking populations; 3) identify and propagate resilient individuals and genes throughout the population without losing overall genetic diversity; and 4) incorporate the study and use of reproduction, adaptation and resilience to prevent species extinctions.

Building an International Code of Conduct for Genomic and Health-Related Data Sharing Anne-Marie Tassé, Public Population Project in Genomics and Society (P3G)

Both an aspirational and practical instrument, the International Code of Conduct for Genomic and Health-Related Data Sharing has been developed in collaboration with many international organizations such as the GA4GH, P3G, BioSHaRE-EU, H3A, ICGC, INSERM, and IRDiRC. Founded on a human rights framework (namely right to the benefits of science; right of attribution; and right of scientific freedom) and based on the premise that such data sharing has been approved and consented to, the Code considers international data sharing to be both a scientific and social benefit, and responds to the new challenges raised by international, collaborative research.

Translational Applications of Biobanking: The Fibroblast Growth Factor 23 Story Myles Wolf MD, MMSc , Northwestern University, Chicago, USA

Abnormal regulation of fibroblast growth factor 23 (FGF23) was originally discovered as the cause of rare hereditary forms of hypophosphatemic rickets. This presentation will review how biobanked specimens from several large cohorts were used to transition FGF23 from molecular mechanism of rare Mendelian diseases to emerging, mainstream risk factor for cardiovascular disease, kidney disease progression and death.

Cell Processing and Preservation for Biobanking: New Horizons Erik Woods PhD, Cook General BioTechnology, Indiannapolis, USA

As preservation of living cells becomes a critical need of biorepositories, a look back at methods for processing, transporting and storage becomes paramount. Lessons learned from cryobiology can become valuable tools new horizons in biobanking.

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

China National GeneBank, Making the Resource Valuable to Everyone Yong Zhang, PhD, China National GeneBank, Shenzhen, China

China National GeneBank is aiming to store 30 million samples and 500PB data. It will contain human and non-human resource. With the coming sequencing technologies, we have series solutions (very low cost) where we could collaborate with all the other biobank for a new biobank era: digitalization of biobanks and AppStore of biobanks. The Alliance will also help people both in scientific world and industrial world. As one of ISBER working group, we are putting lots of effort to education, training, etc. We believe that we should together provide a universal platform and let all biobanks, researchers, and industrial people working together.

Financial Sustainability in Biobanking: Moving Past Models to Real World Experiences in Biobanks Ranging from Country-Wide and Regional Networks, to Large Medical Centers, to Non-Profit, to Government Biobanking is a key component of personalized medicine. The complexity of biobanking is increasing with the demands to improve specimen and data quality, scientific methodology, safety, operations, ethical and legal infrastructure. These improvements escalate the cost of the biobanking business across the continuum. Long term financial sustainability must be

maintained to maximize the benefit of biobanking to global health. The need to sustain biobanking to support global health is a challenge of buyin of all stakeholders; financial support from many different sources; and risk management. This interactive session will provide views from several biobanking experts and their in-process approach to sustainable operations. This session encourages audience participation through interaction with the moderators who will pose questions to the audience through handheld polling tool and a panel discussion. Please come and participate! Moderators: Dr. Peter Watson, Director of the Tumour Tissue Repository at the British Columbia, Cancer Agency, Canada, Dr. Brent Schacter, Professor in the Department of Internal Medicine of the University of Manitoba and member of the Department of Medical Oncology and Hematology at CancerCare Manitoba, Canada, Mr. Rusty Bromley, Chairman of the Board, Vascular Cures, A non-profit foundation dedicated to developing new treatments and cures for vascular disease. Redwood City, California, USA, Dr. Brian Thomson, Associate Professor and Honorary Consultant, Nottingham University, United Kingdom, Dr. Peter Riegman, Head of the Erasmus MC Tissue Research Support Unit which includes the Erasmus MC Tissue Bank. Rotterdam, The Netherlands, Dr. Jan-Eric Litton, Director General of BBMRI-ERIC, Graz, Austria and Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Dr. Jim Vaught, Independent consultant and Editor-inChief at Biopreservation & Biobanking, a Mary Ann Liebert, Inc. publication and the official journal of ISBER, Kensington, MD, USA, Dr. Balwir Matharoo-Ball, Operations Manager for Translational Research and Nottingham Health Science Biobank, David Evans Medical Research Centre, Nottingham, UK

ISBER Education and Training Workshop Summaries (separate registration required) Tuesday May 20, 2014

Workshop 1A • 07:00 – 08:30 “Fit for Purpose” Protocol Planning: A Tutorial to Facilitate Evidence Focused Biobanking Practice – in Real Time Facilitators: Lisa B. Miranda, Melissa Rawley-Payne, MA, Helena Judge Ellis, Mark Bouzyk, PhD

This workshop will increase the attendees’ knowledge base regarding evidencebased biobanking, specifically related to development of “fit for purpose” sample management protocols. Attendees will actively participate in a presentation of a “fit for purpose” protocol planning exercise. Guidance will be offered in tandem with substantive audience discussion around relevant use cases. The workshop will enable attendees to obtain and share feedback with peers aimed at increasing understanding and consensus of opinion regarding factors for selection of quality control parameters, crucial considerations for evidence based sample management practices and technical requirements to enable “fit for purpose” readiness of their current biobanking operations.

Objectives: • Increased understanding of the following concepts and related requirements »» Evidence based biobanking and fit for purpose;

»» Biospecimen lifecycle and process chain quality requirements »» Overview of indirect and direct QC measures »» Biobanking related outcome measures • Obtain real time guidance on FFP and EBBP Protocol development/ Audit readiness • Acquire peer and biobank community feedback on relevant additions to the fit for purpose protocol development framework

Workshop 1B • 08:45 – 10:45 Surveys, Migration, and Changes – Informatic Considerations for Biobanks Facilitators: Kevin Meagher, Piper Mullins, MSc, Ashok Patel, MD, Mark Cada

This workshop will provide an overview of essential topics when choosing a new or migrating to a different inventory management system (i.e. specimen database). Repositories use an inventory management system to track specimen locations, acquisitions, history, usage, and loans; provide metadata related to the sampled subject; and share data with other research communities. Choosing and implementing an information management system is essential to successful repository workflow. Without accurate information about the specimens in the repository and their associated data, the effort to find, retrieve, and maintain

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the collection can become an overwhelming task requiring significantly greater manpower resources. Presenters will discuss best practices for managing change in the biobank’s informatics infrastructure, migrating legacy data to new systems, and linking specimen data to other data sources such as EMR’s or organizational catalogs. This workshop will also highlight data sharing considerations for information management systems, and will discuss open access catalogs and minimum required metadata / database fields. Significant ISBER research is publicly funded with requirements to make the specimen information publicly available, and this session will educate participants on setting up their databases to meet those requirements. The workshop will also review ISBER IT Best Practices as well as results of the 2013 IWG survey.

Objectives: This workshop is offered by the Informatics Working Group in an effort to share our experiences and best practices with information management systems and repository databases. We will provide a “hands-on” session to explain in lay terms the importance of implementing well-designed databases with specific metadata. Participants from non-informatics background will gain understanding of 1) best practices for implementing or migrating information systems for choosing new inventory software systems, especially during the repository design phase, 2) considerations for pushing data to public catalogs, and 3) an increased awareness about the importance of Informatics in biobank operations.

Workshop 1C • 11:00 – 12:30 Are You Prepared? Case Studies in Balancing Biospecimen-related Patient and Investigator Requests with Risk Management and Human Subjects Protections in the Age of Genomic Medicine Facilitators: Marianna Bledsoe, MA, Mary E. Edgerton, MD, PhD, Ty Hoover, MD, JD, Nicole Sieffert

Case studies of increasingly complex recurring events that years ago were unheard of, but are becoming increasingly frequent at institutions of various sizes, will be presented and discussed including, but not limited to: • Patient requests for tissue procurement and distribution services »» With little or no notice »» To questionable recipients »» Without specific instructions, supplies, appropriate authorization • Departing investigator desire for specimen transfer • Donor desire to direct biospecimen distribution at will • How data plays into these scenarios – What should be recorded? How? When should it be shared? With whom? • Concerns include but are not limited to: »» Patient, Investigator and Institutional protection »» Ethical concerns regarding denial of patient requests vs. patient protection »» The increasingly blurry line between clinical and research activity »» Increasingly difficult data management and biospecimen tracking

Workshop 2A • 07:00 – 08:30 Implementing Robust Quality Management Systems for Repositories Facilitators: Judith Giri, PhD, Elaine Gunter, MT (ASCP), Barbara Glazer, MT (ASCP), Phil Baird, MS

A comprehensive quality management (QMS) is needed to ensure the consistent, optimal operations of a repository, in order to preserve the integrity and future value of specimens. The workshop will address the essential elements of a QMS, resources needed and ensuring that written protocols are consistently practiced and monitored. The workshop will address practical topics including among others: development of written standard operating procedures, preparing for inspections, ensuring the integrity of inventory data, facility management and training of repository staff, and promoting continued quality improvements. The information presented will complement ISBER Best Practice Guidelines, with specific details and QMS models.

Objectives • Gain a greater appreciation of the need for strong quality management systems (QMS) for repositories • Provide practical guidance for developing and implementing the main components of a QMS, to complement ISBER Best Practice Guidelines

Workshop 2B • 08:45 – 10:45 Part 1: Biospecimen Science: Learning from Cryobiology to Improve Preservation Outcome Facilitators: Rebecca Spindler, PhD, Mark Cosentino, PhD, Erik Woods, PhD

This workshop is jointly sponsored by ISBER and Society for Cryobiology (SFC). The workshop is intended to cover fundamentals of preservation including steps that are critical to favorable outcome. In addition, a discussion of practical hints and tips for individuals involved in preservation or supervising those involved in preservation. Finally, factors that influence stability of biospecimens in longterm storage will be discussed.

Part 2: Keep Your Samples Safe: Choose the Appropriate Storage Container Facilitator: Alexandra Lerch-Gaggl, PhD

The choice of the optimal storage container for a biological sample seems minimal compared to the multitude of steps, which are involved in preparing samples for long-term storage, but it is a crucial one. Different sample types might need different container vessels in order to keep specimens safe and intact.

Objectives • Identify variables, which influence the quality of their specimens • Describe pros & cons of various storage containers • Describe factors, which help guarantee reproducible sample identification

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Workshop 2C • 11:00 – 12:30 Limitations in the Use of Human and Animal Tissues in Research: What Biorepositories and Investigators Need to Know Facilitator: William E. Grizzle, MD, PhD

Biorepositories collect, process, store and distribute tissues to support a wide range of research. This presentation will discuss the limitations in supporting biomedical research due to specific variables affecting tissues. Topics include the effects on research of 1) of heterogeneity of solid tissues, 2) fixation, alternate forms of fixation, and processing of tissues to paraffin, 3) storage conditions of frozen tissue, paraffin slides, and paraffin blocks, 4) surgical variables (e.g., warm ischemia, cautery artifacts, and cold ischemia), 5) sources of bias, and 6) use of a quality management system (QMS) to improve the usefulness of tissues for research.

Objectives: To introduce the concept of differences in pre-analytical variables and potential effects on research. • To present how bias arises due to differences in the collection, processing, storing and distribution of tissues. • To describe how QMS improves the quality of tissue and reduces bias.

Workshop 3A • 07:00 – 09:30 Part 1: Issues to Consider in Designing a Repository Part 2: The Nuts and Bolts of Operating a Repository Facilitators: Katherine C. Sexton MBA, William E. Grizzle MD, PhD

This workshop seeks to educate the audience on the various issues that need to be recognized and dealt with in designing and managing a biorepository. The workshop will be useful to anyone thinking about or planning to establish a biorepository, as well as others who may have already started one, but would be interested in finding out how to further develop and expand their biorepository services. Part 1 of this workshop leads the audience through questions that should be asked and answered when considering the establishment of a human tissue biorepository. The answers to the questions will help them design the biorepository that is right for their needs. Part 2 delves more deeply into the details and issues of running and maintaining a biorepository.

Objectives: • Gain insight about the various repository models available • Learn what issues should be considered when designing and operating a repository • Discuss the various types of services your repository might want to provide (without performing the investigator’s research for them!) • Understand the importance of quality control and safety in the repository

• Gain a better understanding about the legal, ethical, and regulatory issues that may affect the repository • Understand the “nuts and bolts” of operating a repository • Identify space and resources needed to begin a repository

Workshop 3B • 09:45 – 11:15 Essential concepts for effective specimen receipt Facilitators: Karen Pitt, PhD, Rebecca Pugh, MS

This workshop will teach participants to describe and establish effective processes for receiving a broad range of specimen types (e.g., human, nonhuman, museum, etc.) into a biorepository. The topics covered will range from communications with the entity sending the specimens, ensuring the proper storage environments are available within the repository, evaluating the condition of the specimens upon receipt, addressing discrepancies, and tracking the specimens from the time of delivery until they are transferred to their temporary and more extended storage locations.

Objectives: • Describe the process by which specimens are received at the repository, inspected and prepared for interim or long term storage. • Describe how information about compromised specimens is entered into the inventory system and how it is communicated to the shipper or clients. • Describe how the location for newly arrived shipments is tracked in the repository after receipt and what immediate process/handling steps must take place, as needed.

Workshop 3C • 11:30 – 13:00 Creating Successful Training Programs for Repository Staff Facilitators: Karen Pitt, PhD, Alexandra Lerch-Gaggl, PhD

This course will teach participants the important components of successful training programs for repository staff. Areas covered will include the identification of training needs in repositories, development of effective training tools, an understanding of the skills needed for the trainer and trainee, and a process for implementing the training that includes the creation of training records. This information will be applicable to a broad range of specimen types (e.g., human, non-human, museum, etc.).

Objectives: • Evaluate the role of training in effective repository operations and the preparation of high quality specimens for research. • Discuss factors that contribute to effective training programs. • Describe the qualities of those best suited to administer training.

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ISBER Education and Training Workshop Summaries (separate registration not required) Saturday May 24, 2014

Workshop 1A • 08:30 – 09:30

Workshop 2A • 09:45 – 10:45

HELL OR HIGH WATER: THE ALBERTA CANCER RESEARCH BIOREPOSITORY DISASTER READINESS, RESPONSE AND RECOVERY

WEATHERING THE STORM: ASSESSING BUSINESS CONTINUITY MEASURES IN BIOREPOSITORY OPERATIONS

Facilitators: Nigel Brockton, PhD, Charlene Karvonen

Natural disasters like hurricanes and earthquakes and other events like equipment failure and chain-of-custody issues can threaten the existence of established biorepository operations. To mitigate these risks, organizations should establish strategic plans outlining procedures and protocols that alleviate the effects a disaster might have on sample inventories and research operations. As drug discovery and development become increasingly reliant on properly preserved samples, protecting these materials has become an even greater priority.

In June of 2013, Calgary, Alberta, experienced unprecedented flooding. The Alberta Cancer Research Biorepository (ACRB) biostorage facility was located in a site that was threatened, and ultimately engulfed, by the rising waters. During this workshop attendees will work through simulated disaster scenarios to help them anticipate and prepare for multiple emergency situations. Participants will be provided with and develop a template for their own Disaster Readiness, Response and Recovery Plan by responding to a MOCK Disaster. This will help develop their emergency response plan, organize an approach for disaster recovery plan and propose the minimum criteria for business resumption.

Facilitators: Kristina Robson, Andrew Brooks, PhD

This workshop will review a real-world case study in which hundreds of thousands of research samples were rescued from New York University medical centers in days after Hurricane Sandy.

Objectives:

Objectives:

• Learn how to prepare a plan for various potential disasters/threats. • Learn how to organize your business resources to assist an effective response to a disaster • Learn how to implement systems and processes to keep your Emergency Response Plan up to date.

• Best practicing for selecting business continuity partners to support the protection of sample inventories. • How best to establish cost-effective redundancies and action steps that your company can employ with research partners. • Learn best practices in the development of a business continuity and disaster recovery plan to protect research samples.

Workshop 1B • 08:30 – 09:30 INFORMED CONSENT FOR GENOMICS: POLICIES, PROBLEMS AND PRACTICAL APPROACHES

Workshop 2B • 09:45 – 10:45 ELSI CHALLENGES IN BIOBANKING & GENOMICS RESEARCH

Facilitators: Marianna J. Bledsoe, Amelia Warner, Anita Nelsen

Facilitators: Pedro Rondot Radío, Rosario Isasi, Anne Marie Tassé

This workshop will explore current policy developments and requirements regarding genomic sequencing and genomic data sharing and informed consent practices when human specimens are used for genomics research. It will address these issues from both a US and international perspective and emphasize practical approaches to overcome challenges in this area. Practical approaches and real world examples of regulations and policies for genomics studies based on experiences from multinational clinical trials and other multinational studies will be presented and discussed.

Biobanking activities are of major scientific importance since they allow for the creation of very large datasets - as needed to study complex disease aetiology -, optimize the use of already collected research material and avoid the limitations of research conducted among smaller numbers of participants. While the literature on biobanking has traditionally focused on issues such as informed consent, privacy, access and return of research results, emergence of biobanking activities in new research domains, such as stem cell research, has raised unexpected socio-ethical and legal issues (ELSI). Moreover, internationalization of research activities and development of international research consortia has clearly shown the limitations of nationally based legal and ethical frameworks. This workshop aims to provide the audience with the “building blocks” of ELSI in biobanking and genomics medicine. It has two distinct but complementary goals. First, the workshop aims to provide an overview of the most pressing ethical and legal issues in biobanking, and illustrate answers provided by the traditional normative approach to biobanking. Second, it aims to demonstrate the emerging issues raised by biobanking activities in novel research settings. Biobanking for stem cell research and international research consortia will be used as case studies to illustrate these new issues, as well as the latest ethical and normative responses.

Objectives: • Provide an overview of current policies and issues related to informed consent for genomics research. • Discuss current approaches and practices on a global level that can facilitate the collection and use of human specimens for genomic research.

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

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Tuesday, May 20th at 5:15 pm Join us for “Managing the Past for the Future,” an exciting ISBER workshop featuring Joël Doré, Ph.D, 41 MICALIS Institute, MetaGenoPolis, and INRA, France. Dr. Doré will describe the leading edge scientific research in the Human Gut Microbiome and use of CryoXtract’s frozen aliquotting technology as an www.isber.org integral part of INRA’s sample preparation workflow. Cocktail reception to follow.

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

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Connect globally to leading professionals in BIOREPOSITORIES. Join ISBER today! Organizational Membership: Includes 2, 4, or 6 Individual Delegates Access to ISBER Best Practices for Biorepositories and Self-Assessment Tool (SAT) Product/service posting on ISBER MarketPlace Online subscription to Biopreservation and Biobanking – ISBER’s official journal Discounted exhibit space and registration rates for the ISBER Annual Meeting & Exhibits Advertising opportunities at a discounted rate Online jobs board at: www.biobankingjobs.com

Individual Membership: Access to ISBER Best Practices for Biorepositories and Self-Assessment Tool (SAT) Reduced registration rates for the ISBER Annual Meeting & Exhibits Online subscription to Biopreservation and Biobanking – ISBER’s official journal Online subscription to the ISBER Newsletter – the quarterly member e-newsletter Connect to a global group of professionals in biospecimen banking through the ISBER Members-only Forums Online jobs board at: www.biobankingjobs.com

International Society for Biological and Environmental Repositories Head Office: 570 West 7th Avenue, Suite 400, Vancouver, BC, V5Z 1B3, Canada T: 1-604-484-5693 • F: 1-604-874-4378 • E:[email protected]

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Posters ABSTRACT ID

TITLE

Presenter*

Country

BRS 01

SERUM ALBUMIN CONCENTRATIONS IN HIV PATIENTS BEFORE AND AFTER HIGHLY ACTIVE ANTIRETROVIRAL THERAPY: A RETROSPECTIVE AND MULTI-ETHNIC COHORT IN LONDON, UK, USING BANKED DATA AND SAMPLES

Z. Kozlakidis

United Kingdom

BRS 02

MULTILAYERED MOLECULAR PROFILING SUPPORTED THE MONOCLONAL ORIGIN OF METASTATIC RENAL CELL CARCINOMA

S. Wu

China

BRS 03

WHOLE GENOME DEEP SEQUENCING DECOMPOSES THE GENOME EVOLUTION OF RENAL CELL CARCINOMAS

S. Wu

China

BRS 04

CHINESE VIRUS RESOURCE AND BIO-INFORMATION CENTER

T. Li

China

BRS 05

METHOD VALIDATION FOR STOOL DNA EXTRACTION

G. Hamot

Luxembourg

BRS 06

APPLICATION OF THE CMA TECHNOLOGY IN STEM CELLS RESEARCH

P. De Blasio

United States

BRS 07

BUILDING AND APPLYING A CHRONIC DISEASE BIOBANK BASED ON THE INFORMATIONIZATION OF COMMUNITY HEALTHCARE IN SHANGHAI

M. Yuan

China

BRS 10

UTILITY OF CLINICAL CHEMISTRY ITEMS AS THE QUALITY ASSESSMENT MARKERS FOR DELAYED BLOOD SEPARATION IN BIOBANKING

H. Shin

Korea, Republic of

BRS 12

THE BIOSPECIMEN METHODOLOGICAL STUDY (BMS): EVIDENCE TO GUIDE BEST PRACTICES FOR POSTMORTEM TISSUE PRESERVATION

A. Rao

United States

BRS 13

EVALUATION OF PROGRP AS A QUALITY CONTROL MARKER FOR PROPER STORAGE OF FROZEN PLASMA SAMPLES IN A BIOBANK

S. Shin

Republic of Korea

BRS 14

PRE-ANALYTIC VARIATION IN ANTIBODIES TO INFECTION FROM PERIPHERAL BLOOD

V. Hodgkinson

Australia

BRS 15

CANDIDATE CYTOKINE MARKERS FOR QUALITY CONTROL OF DELAYED BLOOD SEPARATION IN BIOBANKING J. Lee

Republic of Korea

BRS 16

OPTIMIZATION OF PRESERVATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN BIOBANK

M. Sun

China

BRS 17

BIOBANKING AS A BASIS FOR PERSONALIZED MEDICINE PROGRAM (PMP) AT SHEBA MEDICAL CENTER

Y. Cohen

Israel

BRS 18

DNA EXTRACTION FROM CLOTTED BLOOD USING A SEMI-AUTOMATED METHOD

S. Kollis

United States

BRS 19

PRECISION LABORATORY NETWORK RNA PROCESSING SUITABILITY STUDY

F. Bahunde

United States

BRS 21

NEW CONTAINERS FOR FROZEN TISSUE CONSERVATION STANDARDIZE THE CRYOSTAT SECTIONING PROCESS

R. Lawlor

Italy

BRS 22

DNA FROM BUFFY COAT STORED IN A NOVEL BIOSTABILIZER AT ROOM TEMPERATURE PERFORMS EQUIVALENTLY TO DNA FROM FROZEN BUFFY COAT IN ILLUMINA INFINIUM GENOTYPING

M. Donaldson

Canada

BRS 23

SIMPLE ASSAYS FOR MONITORING CELL HEALTH

S. Withers

United States

BRS 24

REDUCING COST, ENERGY, AND SPACE CONSUMPTION FOR BIOLOGIGICAL SAMPLE STORAGE

R. Heaton

United States

BRS 26

AN EMERGING ROLE OF BIOREPOSITORIES IN PERSONALIZED MEDICINE: ISOLATION AND PROCESSING OF PRIMARY TUMOR CELLS FOR THE ESTABLISHMENT OF 3D TUMOR CULTURES FROM SOLID TUMOR SPECIMENS

K. Valyi-Nagy

United States

BRS 28

POTENTIALS AND PITFALLS IN BIOBANKING FOR BIOSPECIMENS OF NEUROLOGICAL RARE DISEASES(NRD’S)

R. Ravid

The Netherlands

BRS 29

MEMBRANE STABILIZING EFFECT OF LIPOSOMES ON RAT RED BLOOD CELLS

J. Acker

Canada

BRS 30

THE IMPACT OF STORAGE CONDITIONS ON DNA-DERIVED FROM BUCCAL SWABS

C. White

United States

BRS 31

HCV STATUS AND OTHER PRE-ANALYTICAL VARIABLES INFLUENCE DNA YIELD FROM WHOLE BLOOD

J. Hoskins

United States

BRS 32

TRACKING SAMPLE TEMPERATURE OVER TIME TO DETERMINE SAMPLE STABILITY IN BIOREPOSITORIES

L. Clark

United States

BRS 34

BIOBANKING FOR MATERNAL AND CHILDREN’S HEALTH: A UNIQUE RESOURCE FOR LONGITUDINAL COHORT STUDY OF PREGNANT OUTCOMES

J. Pang

China

BRS 36

INTERACTION BETWEEN GENETIC POLYMORPHISMS AND RISK OF ORAL CANCER

G. Wong

Malaysia

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International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

ABSTRACT ID

TITLE

Presenter*

Country

BRS 37

A MODEL FOR ACCELERATING RARE RESEARCH THROUGH LINKING PATIENT CLINICAL DATA TO BIOSPECIMENS

Y. R. Rubinstein

United States

ELSI 02

REQUESTING AND SHARING REAGENTS, BIOSPECIMENS AND DATA THROUGH THE NEW TECHNOLOGY AGREEMENT DASHBOARD AT THE US NATIONAL INSTITUTES OF HEALTH. IT’S EASY!

M. Henderson

United States

ELSI 04

COVERING THE CONSENT FORM AND PROCESS: THE LIVER DISEASE BIOBANK EXPERIENCE

A. Salman

Canada

ELSI 05

ETHICAL ISSUES SURROUNDING INFORMED CONSENT AS ENCOUNTERED BY THE NHLS STELLENBOSCH BIOBANK – H3AFRICA

B. Van Rooyen

South Africa

ELSI 09

THE SUSTAINABILITY OF BIOREPOSITORIES: THE ETHICAL DILEMMAS OF INFORMED CONSENT IN THE FACE OF COMMERCIALIZATION

K. D’Angelo

United States

ELSI 10

PARTICIPANT AUTONOMY AND UNDERSTANDING IN OPEN ACCESS DATA SHARING

S. Pereira

United States

EPSR 04

The International Environmental Specimen Bank (IESB) Group

R. Pugh

United States

EPSR 05

PLANT VIRUS GENBANK

J. An

Republic of Korea

HSR 01

PATHOLOGISTS’ ASSISTANT ROLE IN A BIOBANK

M. Rau

United States

HSR 02

A CALL TO STANDARDIZE PREANALYTIC DATA ELEMENTS FOR BIOSPECIMENS

J. Robb

United States

HSR 04

STORAGE OF URINE ON MEMBRANE MAKES THE COMPREHENSIVE BIOBANKING OF CLINICAL SAMPLES POSSIBLE

Y. Gao

China

HSR 05

KOREA GYNECOLOGIC CANCER BANK

H. Kwon

Republic of Korea

HSR 06

STREAMLINE BIOSPECIMEN AVAILABILITY AND MAXIMIZE QUALITY TO ADVANCE PERSONALIZED MEDICINE

A. Liu

United States

HSR 07

DEVELOPMENT OF A SEER VIRTUAL TISSUE REPOSITORY

G. Rosenfeld

United States

HSR 08

THE CENTER FOR REGENERATIVE MEDICINE (CRM) BIOTRUST: A BIOBANK FACILITATING THE TRANSLATION OF REGENERATIVE THERAPIES AT MAYO CLINIC

Z. Resch

United States

HSR 09

ESTABLISHMENT OF MINHANG BIOBANK BASED ON ELECTRONIC HEALTH RECORD SYSTEM IN SHANGHAI, CHINA

Y. Zhao

China

HSR 11

A BIOBANK-BASED SOLUTION FOR A MULTI-INSTITUTIONAL WORKING GROUP FOR THE STUDY OF PENILE A. Campos CARCINOMA IN BRAZIL

Brazil

HSR 12

ESTABLISHMENT AND MAINTENANCE OF A STANDARDIZED GLIOMA TISSUE BANK: HUASHAN EXPERIENCE

A. Aibaidula

China

HSR 13

ONE SMALL STEP FOR BIOBANKING: WORKING TOWARDS IMPROVED NETWORKING OF CANCER BIOBANKS

A. Rush

Australia

HSR 14

THE NIDDK CENTRAL REPOSITORIES: AN NIH RESOURCE FOR RESEARCH ON TYPE 1 DIABETES

R. Rasooly

United States

HSR 15

DESIGN AND IMPLEMENTATION OF A NATIONWIDE, IN-HOME, BLOOD COLLECTION IN THE WOMEN’S HEALTH INITIATIVE

S. Mann

United States

HSR 16

AUSTRALIA’S NEXT TOP MODEL: EXPEDITING AND SIMPLIFYING INFORMED CONSENT FOR SAMPLE DONATION AT DIAGNOSIS OF ACUTE HEMATOLOGICAL MALIGNANCIES

N. Sprigg

Australia

HSR 17

BUSINESS PLANNING FOR ASSESSING AND DEVELOPING A PEDIATRIC AND WOMEN’S ORIENTED BIOBANK

T. Tarling

Canada

HSR 18

DEVELOPING TUMOR TISSUE BANK TO ACCELERATE CANCER TRANSLATIONAL RESEARCH

H. Li

China

HSR 19

FACTORS INFLUENCING SPECIMEN ACCRUAL IN A BIOBANK WITH AN ATTEMPT TO UNDERSTAND THE GENERAL MINDSET OF THE POPULATION: A COMMUNITY HOSPITAL PERSPECTIVE

S. Tolay

United States

HSR 20

THE VENTYX WESLEY RESEARCH INSTITUTE TISSUE BANK

E. Raymond

Australia

45 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

ABSTRACT ID

TITLE

Presenter*

Country

HSR 21

NATIONAL CHILDREN BIOBANK IN CHINA: THE FOUNDATION OF TRANSLATIONAL MEDICINE RESEARCH IN PEDIATRIC FIELDS

P. Chu

China

HSR 22

A NOSOCOMIAL CLINICAL SPECIMEN BANK IN LARGE COMPREHENSIVE HOSPITAL

L. Yin

China

HSR 23

BIOBANK BRANCH, CHINA MEDICINAL BIOTECH ASSOCIATION

H. Zhou

China

HSR 25

BIOBANK OF NATIONAL ENGINEERING CENTER FOR BIOCHIP AT SHANGHAI

H. Zhou

China

HSR 26

BIOBANKS SHIFT TO PRECISION MEDICINE

P. De Blasio

United States

HSR 27

CREATION AND INITIAL IMPLEMENTATION OF A FEDERATED TISSUE REPOSITORY SYSTEM AT AN ACEDEMIC MEDICAL CENTER WITH MULTIPLE PRE-EXISITING BIOREPOSITORIES

J. Galbraith

United States

HSR 28

THE GENOTYPE-TISSUE EXPRESSION PROJECT

L. Carithers

United States

HSR 29

SPECIAL CONSIDERATIONS FOR BIOBANKING OF INFECTIOUS DISEASES IN CHINA

L. Liu

China

HSR 31

THE NATIONAL CANCER INSTITIUTE SPECIMEN RESOURCE LOCATOR A SEARCHABLE DATABASE TO LOCATE HUMAN SPECIMENS

J. Demchok

United States

HSR 32

THE UK BREAST CANCER CAMPAIGN TISSUE BANK (BCCTB)

B. Matharoo-Ball

United Kingdom

HSR 33

LIVER DISEASE BIOBANK: A MOVING TARGET FOR RESEARCH AND CLINICAL STUDY INTEGRATION

A. Lazaris

Canada

HSR 34

DATA ON THE DEVELOPMENT OF RESOURCES FROM A 2-YEAR-OLD TUMOR BIOBANK IN NEW ZEALAND

D. Mason

New Zealand

HSR 36

BIOLOGICAL SPECIMEN RESOURCES AND ITS EPIDEMIOLOGICAL DATABASE FOR ADVERSE PREGNANCY OUTCOMES: FROM A COHORT STUDY

C. Huang

China

HSR 37

CONSTRUCTION OF CHRONIC KIDNEY DISEASE BIOBANK IN BEIJING

X. Zhang

China

HSR 38

NANJING BIO-BANK, A HEALTH DEPARTMENT DOMINATED AND HOSPITAL SUPPORTED MULTI-CENTER BIO-BANK IN CHINA

Q. Ye

China

HSR 39

BUILDING A QUALITY DRIVEN GLOBAL LABORATORY NETWORK FOR PRE-ANALYTICAL PROCESSES

K. Shea

United States

HSR 40

STREAMLINING TRANSLATIONAL RESEARCH THROUGH INTEGRATED BIOBANKING AND CORE FACILITIES

B. Pruetz

United States

HSR 42

AN INFORMATIONAL CHILDREN’S BIOBANK

S. Liu

United States

HSR 43

ROOM TEMPERATURE BIOSPECIMEN TRANSPORTATION THROUGHOUT AFRICA AS AN ALTERNATIVE COST C. Swanepoel EFFECTIVE SOLUTION TO COLD CHAIN LOGISTICS: THE NSB-H3A EXPERIENCE

South Africa

HSR 45

DEVELOPING RECOMMENDED BEST PRACTICES FOR BIOBANKING OPERATIONS AND GOVERNANCE FOR THE UNIVERSITY OF CALIFORNIA SYSTEM

S. Dry

United States

HSR 46

EXPANSION OF A MULTIDISCIPLINARY BIOBANK TO A SISTER SATELLITE

D. Larson

United States

HSR 47

BIOSPECIMEN PREPARATION AND BIOPROCESSING TECHNIQUES THAT OPTIMIZE SAMPLE COLLECTIONS FOR FUTURE RESEARCH

K. Robson

United States

HSR 48

DIAGNOSTIC PATHOLOGY – KEY TO BIOBANKING SUSTAINABILITY

Z. Prodanovic

Australia

HSR 49

ESTABLISHMENT OF FUDAN UNIVERSITY BIOBANK NETWORKING

M. Sun

China

HSR 50

THE DUKE HUMAN HEART REPOSITORY (DHHR)

D. Bowles

United States

HSR 51

ESTABLISHING A JOINT BREAST CANCER BIOBANK WITH A SHAREABLE SPECIMEN AND DATA COLLECTION AND TRACKING SYSTEM

A. Margossian

United States

HSR 52

POSSIBLE LINK BETWEEN PLUTONIUM EXPOSURE AND RARE LIVER CANCERS REVEALED BY THE RUSSIAN C. Loffredo RADIOBIOLOGICAL HUMAN TISSUE REPOSITORY (RHTR)

United States

HSR 53

METABOLIC DISEASES BIOBANK AT SHANGHAI JIAO TONG UNIVERSITY AFFILIATED 6TH PEOPLE’S HOSPITAL, SHANGHAI, CHINA

China

46

International Society for Biological and Environmental Repositories

C. Wang

ISBER 2014 Scientific Program

ABSTRACT ID

TITLE

Presenter*

Country

HSR 54

BIOBANKING OF CIRCULATORY TUMOR CELLS (CTCs) AND THEIR RELATED MATERIALS AT CLINICAL LABORATORIES

K. Furuta

Japan

HSR 56

THE APPLICATION OF “DISEASE-SPECIFIC INFORMATION CARD” IN THE MANAGEMENT OF MULTIPLE DISEASES BIOBANK

J. Zhou

China

HSR 57

ESTABLISHING A HIGH QUALITY BIOBANK TO PROMOTE PEDIATRIC TRANSLATIONAL RESEARCH

J. Zhou

China

HSR 58

BUILDING A STATE OF ART BIOREPOSITORY BY HYBRIDIZING ELECTRONIC DATA CAPTURE SYSTEMS IN A LIMITED RESOURCE COUNTRY

S. Ezzat

Egypt

HSR 60

ESTABLISHMENT OF THE QUEBEC PANCREATIC CANCER STUDY (QPCS)

A. Hall

Canada

HSR 61

THE NINDS REPOSITORY: A PUBLIC COLLECTION OF BIOMATERIALS FOR GENE AND BIOMARKERS DISCOVERY IN NEUROLOGICAL RESEARCH

C. Tarn

United States

HSR 62

THE VAN ANDEL RESEARCH INSTITUTE’S PROGRAM FOR BIOSPECIMEN SCIENCE: BIOREPOSITORY MANAGEMENT FOR THE MULTIPLE MYELOMA RESEARCH FOUNDATION’S COMMPASS CLINICAL TRIAL

S. Jewell

United States

HSR 64

CONDUCTING A BIOSPECIMEN COLLECTION BY MAIL: APPROACHES, SUCCESSES AND LESSONS LEARNED S. Sawyer

United States

HT 01

HELL OR HIGH WATER: THE ALBERTA CANCER RESEARCH BIOREPOSITORY DISASTER READINESS, RESPONSE AND RECOVERY

C. Karvonen

Canada

HT 02

MAXIMIZING RESEARCH IMPACT ACROSS BIOREPOSITORIES: TOOLS FOR CREATING ACCESSIBLE, OPEN SOURCE METADATA RECORDS TO IDENTIFY BIOSPECIMEN AVAILABILITY, USE AND ANALYSIS ACROSS REPOSITORIES

J. Mcnally

United States

HT 03

HAVE BIOSPECIMENS WILL TRAVEL ...MAYBE! (LESSONS LEARNED IN POLICY DEVELOPMENT REGARDING BIOSPECIMEN TRANSFER FOLLOWING PI DEPARTURE)

N. Sieffert

United States

HT 04

CLINICAL BIOSPECIMENS CERTIFIED FOR NOMINAL PROPERTIES

F. Betsou

Luxembourg

RAT 01

AN AUTOMATED LABORATORY WORKFLOW FOR BLOOD FRACTIONATION AND DNA EXTRACTION

J. Gorman

United States

RAT 02

EFFECTIVE FECES ALIQUOTTING WORKFLOW SUPPORTS INCREASED MICROBIOME RESEARCH

J. Dore

France

RAT 03

ELIMINATING FREEZE-THAW CYCLING OF FROZEN BLOOD SAMPLES USING FROZEN ALIQUOTTING TECHNOLOGY

M. Barnes

United States

RAT 04

COMBINATION OF ELECTRONIC INFORMATION SYSTEM AND PRINTED RECORDING PROMOTE MANAGEMENT EFFICIENCY IN NON-AUTOMATED BIOBANK

Z. Gao

China

RAT 05

TELEPATHOLOGY TO IMPROVE COLLABORATION AND QUALITY OF SAMPLES ANNOTATION IN BIOREPOSITORY

R. Labib

Egypt

RAT 06

BIOBANK GRAZ: UNIQUE AUTOMATED PIPETTING WITH DIRECT FREEZING OF ALIQUOTS

K. Sargsyan

Austria

RM 01

THE CREATION OF A STANDARD TERMINOLOGY FOR BIOBANKING

H. Ellis

United States

RM 02

EFFECTIVE CLINICAL ANNOTATION OF TISSUE BANK PARTICIPANTS: THE CBCF TUMOR BANK EXPERIENCE

A. Driga

Canada

RM 03

PURCHASING DATABASE SOFTWARE FOR IMPLEMENTATION INTO A BIOBANK

E. Raymond

Australia

RM 04

ANALYSIS OF INDUSTRY REQUESTS FOR BIOSPECIMENS

D. SimeonDubach

Switzerland

RM 05

BIOSTOR: A CUSTOMER-CENTERED INFORMATICS PORTAL FOR THE BOSTON CHILDREN’S HOSPITAL BIOBANK

R. Chakrabarty

United States

RM 06

THE FUTURE OF DATA PRESENTATION OR HOW MEDICAL UNIVERSITY OF SOUTH CAROLINA BUILT AN INTEGRATED DATA MANAGEMENT SYSTEM THAT ALLOWS DIFFERENT DATA SOURCES TO RELATE TO COMMON W. Morgenweck ELEMENTS ACROSS THE ENTIRE MEDICAL UNIVERSITY ENVIRONMENT THAT IS EASY TO UNDERSTAND

United States

RM 07

INCREASING SPECIMEN VISIBILITY AND ACCESSIBILITY THROUGH BIOBANK INFORMATICS

H. Dowst

United States

RM 08

APPLYING END-TO-END REAL WORLD PROCESS INFRASTRUCTURE TO BIOBANKING IN THE ACADEMIC SETTING

K. Wiles

United States

47 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

ABSTRACT ID

TITLE

Presenter*

Country

RM 09

SUSTAINING AND MAXIMIZING THE SCIENTIFIC VALUE OF HISTORICAL COLLECTIONS: THE NHLBI BIOREPOSITORY BUSINESS PLAN

E. Wagner

United States

RM 10

BIOBANK IN SUDAN: CURRENT STATUS AND PROSPECTS

I. Abdelhalim

Sudan

RM 11

ARE BIOBANKS USING THE BIOSPECIMENS THEY ARE COLLECTING?

D. SimeonDubach

Switzerland

RM 12

THE ROLE OF BIOBANKS IN RESEARCH, INNOVATION & FORENSICS: SOUTH AFRICAN PERSPECTIVE

B. Duma

South Africa

RM 13

CDR – NCI’S COMPREHENSIVE IT PLATFORM MANAGING BIOREPOSITORY OPERATIONS

P. Guan

United States

RM 14

DESIGNING BIOBANK INFORMATIC PLATFORM FOR TRANSLATIONAL MEDICINE

L. Liu

China

RM 15

A PRACTICAL TOOL FOR MODELING BIOSPECIMEN USER FEES

L. Matzke

Canada

RM 16

BIOBANK CATALOGUE 2.0 AND BEYOND

L. Mook

The Netherlands

RM 17

SUSTAINABILITY IN BIOBANKING – NOTTINGHAM HEALTH SCIENCE BIOBANK

B. Thomson

United Kingdom

RM 19

INTEGRATING SPECIMEN STORAGE, RESEARCH MANAGEMENT, AND CLINICAL RESULTS: DEVELOPING A RESEARCH INFORMATICS SYSTEM FOR A HOSPITAL-INTEGRATED HUMAN TISSUE BIOREPOSITORY

A. Mews

Australia

RM 20

NWBIOTRUST: A CROSS-INSTITUTIONAL INFORMATICS INFRASTRUCTURE FOR REQUESTING AND MANAGING ANNOTATED HUMAN BIOSPECIMENS

S. Ponko

United States

RM 21

NEW GENERATION -80°C FREEZERS FOR BIOREPOSITORY STORAGE

K. Kruckeberg

United States

RM 22

EXPLORING THE POTENTIAL FOR INTEGRATION OF BIOBANKS INTO DIAGNOSTIC LABORATORIES IN NEW ZEALAND TO IMPROVE BIOBANK SUSTAINABILITY

D. Mason

New Zealand

RM 23

ARE WE READY FOR SUSTAINABLE BIOBANKING? A CALL TO ACTION

E. Steinfelder

The Netherlands

RM 24

TRANSFORMING BUSINESS OPERATIONS OF AN ACADEMIC BIOREPOSITORY THROUGH THE UTILIZATION OF MEASURABLE KEY PERFORMANCE INDICATORS

K. Wease

United States

RM 26

CENTRALIZING REQUEST AND SAMPLE INTAKE

S. Hogen

United States

RM 27

THE NEED FOR BUSINESS CONTINUITY AND DISASTER RECOVERY PLANNING FOR RESEARCH SAMPLES

L. Ball

United States

RM 28

A CASE COMPARISON IN COSTS BETWEEN ESTABLISHING LOCAL, INDEPENDENT, RESEARCH COLLECTIONS TO THE UTILIZATION OF AN ESTABLISHED BIOREPOSITORY TO FULFILL RESEARCH NEEDS IN A LONGITUDINAL STUDY

A. Tran

United States

RM 29

BUILDING A REDACTION SYSTEM (REDS) WITH SCIENTIFIC DICTIONARIES AND REGULAR EXPRESSION MATCHING ALGORITHMS (REMA): TO DELETE OR NOT DELETE

Z. Vonmenchhofen

United States

RM 30

DEVELOPING A COST-RECOVERY MODELING TOOL FOR LONG-TERM SUSTAINABILITY OF BIOBANKS

H. Odeh

United States

RM 31

MAXIMIZE INTEROPERABILITY IN COLLABORATIVE BIOBANKS FOR SHANGHAI BIRTH COHORT

W. Wang

China

RM 32

MANAGEMENT OF RESEARCH PROJECTS BY THE AUSTRALIAN BREAST CANCER TISSUE BANK

J. Carpenter

Australia

RM 33

BIOREPOSITORY MANAGEMENT AS THE COMPREHENSIVE BIOSPECIMEN RESOURCE (CBR) FOR THE NATIONAL CANCER INSTITUTE’S (NCI) CANCER HUMAN BIOBANK (caHUB)

D. Rohrer

United States

RM 34

BIOBANK NETWORK: ACCESSIBILITY OF RESOURCES ACROSS REGIONAL BIOBANKS

Y. Wang

China

RM 35

EFFECTS OF ONE-INCH CONCEPTS COMBINES WITH 10 X 10 CONFIGURATION IN CRYOGENIC STORAGE ON THE BIOSPECIMEN SAFETY AND BIOBANK ECONOMY

X. Li

China

RM 36

MANAGEMENT OF PROSPECTIVE PROCUREMENT OF RESEARCH BIOSPECIMENS: APPLICATION OF A WEBR. Mandt BASED INFORMATION SYSTEM

United States

RM 38

TISSUE MORPHOMETRICS USING DEFINIENS TISSUE STUDIO 3.5 FACILITATES TISSUE BASED DATA COLLECTION AND MANAGEMENT

United States

48

International Society for Biological and Environmental Repositories

R. Mandt

ISBER 2014 Scientific Program

ABSTRACT ID

TITLE

Presenter*

Country

RM 39

ENSURING THE FUTURE SUSTAINABILITY OF A DISEASE SPECIFIC BIOBANK

T. Yeadon

Australia

RM 40

PREDICTIVE ANALYTICS FOR BIOSPECIMEN AND BIOREPOSITORY MANAGEMENT OPTIMIZATION

L. Monovich

United States

RM 41

WHICH BUSINESS MODEL FOR BIOBANKS?

R. Warth

Switzerland

RS 01

HOW TO GUIDE FOR GENERATING BIOSPECIMEN IDENTIFIER

S. Nussbeck

Germany

RS 02

QUALITY ASSESSMENT OF PROSTATE TISSUES FROM BENIGN PROSTATIC HYPERPLASIA PATIENTS OPERATED WITH TURP PROCEDURES AND RADICAL PROSTATECTOMY

A. Lin

China

RS 03

DEVELOPMENT OF AN AUTOMATED DNA CLEAN-UP PROCEDURE TO IMPROVE DNA SPECIMEN QUALITY FOR USE IN GENOMIC TECHNOLOGIES

S. Hall

United States

RS 04

A COMPREHENSIVE MULTIDISCIPLINARY BIOREPOSITORY AND CORE MOLECULAR LABORATORY QUALITY PROGRAM

T. Geddes

United States

RS 06

QUALIFICATION OF DIGITAL PATHOLOGY SYSTEMS FOR A BIOSPECIMEN REPOSITORY

T. Barr

United States

RS 07

DEVELOPING A GOLD STANDARD FOR NUCLEIC ACID QUALITY CONTROL: THE IMPORTANCE OF SAMPLE QUALITY AND IDENTITY IN A BIOREPOSITORY SETTING

A. Brooks

United States

RS 08

BEST TOOLS FOR QUALITY SAMPLE MANAGEMENT TRACKING

N. Verna

United States

RS 09

HUMAN PERIPHERAL BLOOD LEUCOCYTE COLLECTION AND QUALITY CONTROL

H. Jin

China

RS 10

DNA FINGERPRINTING: SHERLOCK HOLMES IN THE BIOBANK. A CASE STUDY

O. Kofanova

Luxembourg

RS 11

AN EVIDENCE BASED FRAMEWORK FOR DEVELOPMENT OF “FIT FOR PURPOSE” BIOBANKING SAMPLE MANAGEMENT PROTOCOLS

L. Miranda

United States

RS 12

THE INFLUENCE OF FROZEN THAWING ON RNA QUALITY OF CANCER-TISSUES WITH DIFFERENT PRESERVING METHODS

Y. Wang

China

RS 13

AUTOMATED PBMC EXTRACTION FROM WHOLE BLOOD

W. Ammerlaan

Luxembourg

RS 14

COMPARATIVE EVALUATION OF RNA EXTRACTION FROM HEALTHY AND FAILING HUMAN MYOCARDIUM

L. Martin

United States

RS 15

DEVELOPMENT OF STATISTICAL PROCESS CONTROL PARAMETERS FOR TISSUE QUALITY IN A PREGNANCY RELATED BIOREPOSITORY

D. Chaffin

United States

RS 16

A STREAMLINED PROCESS FOR RECOVERY AND QUALITY ANALYSIS OF DONOR-VERIFIED, HIGH-QUALITY TOTAL RNA INCLUDING miRNAS FROM PAXGENE RNA BLOOD TUBES

V. Kelly

United States

RS 17

RETROSPECTIVE ANALYSIS OF REPORTED ERRORS FOR DEVELOPMENT OF KEY PERFORMANCE INDICATORS

K. Wiles

United States

RS 18

THE ROLE OF CLINICAL COMMISSIONER IN BIO-BANK CONSTRUCTION

D. Cui

China

RS 19

INNOVATIVE TEACHING AND LEARNING APPROACHES FOR CONTINUING PROFESSIONAL DEVELOPMENT EDUCATION IN THE CLINICAL, BIOLOGICAL AND ENVIRONMENTAL BIOBANKING SECTORS A TRANSDISCIPLINARY UNIVERSITY CERTIFICATE IN THE PRINCIPLES OF BIOBANKING

F. Betsou

Luxembourg

RS 20

MONITORING ADEQUACY OF SPECIMENS RECEIVED BY THE BIOPATHOLOGY CENTER (BPC) AT NATIONWIDE CHILDREN’S HOSPITAL

L. Noyes

United States

RS 21

THE IMPACT OF A COMPREHENSIVE QUALITY MANAGEMENT PROGRAM

D. Valley

United States

RS 22

DEVELOPING A CONTINUING EDUCATION PROGRAM FOR A BIOREPOSITORY

E. Pumplun

United States

RS 23

TARGETED COLLECTION PROTOCOL FROM INTACT PROSTATECTOMY SPECIMENS

A. Sharp

United States

* All abstracts are listed by the presenting author (listed at the time of submission)

49 www.isber.org

Custom

BioGenic Systems

50

International Society for Biological and Environmental Repositories

ISBER 2014 Scientific Program

Sponsors Airgas (Booth 220) Airgas provides the right solutions for repository and specimen management. From cryogenic storage systems and liquid nitrogen to vacuum-insulated piping and redundant monitoring and alarm systems, Airgas is the one source for advice and support for protecting irreplaceable biological and clinical samples. We provide state-of-the-art onsite or Airgas-managed offsite cryorepository facilities specifically tailored to your current and future storage requirements. For peace of mind maintaining regulatory compliance, reducing specimen risk, simplifying the management of your systems, and being proactive when it comes to preventive maintenance, you’ll find it with Airgas. Visit us at exhibit number 220.

Artificial Intelligence in Medicine Inc. (Booth 404)

data management experience to their users. Whether you are an independent researcher or a member of a large research institution, SmartBiobank is designed to meet all your data management needs.

AutoGen Inc (Booth 105) AutoGen is now the sole supplier of consumables to the worldwide QIAGEN Autopure LS installed base. Our newly released system, the AutoGen FLEX STAR, automates the isolation of pure genomic DNA from large volumes of whole blood, up to 30 per run, 90 per day. It features positive sample tracking with internal bar code scanning, and the option for integration with the Perkin Elmer Janus liquid handler to automate sample input and DNA transfer steps. It uses Qiagen’s FlexiGene reagents to produce high quality, high molecular weight DNA ready for long term storage, Next-Gen Sequencing, MDx Assays and more. Visit us at booth 105. AutoGen, Inc., 84 October Hill Road, Holliston, MA 01746, Tel: 774-2333003, E-mail: [email protected], Web: www.autogen.com

FROM DISCOVERY TO DIAGNOSIS: AIM’s TissueMetrix information management system is designed for research-orientated biospecimen repositories. It allows organizations to build and maintain a richly annotated catalog of biomaterials for current and future research. This information system is highly scalable, too. Whether it’s a single collection with a small group of users or a multi-collection/ multi-institution environment with a large number of users, TissueMetrix will achieve your biobanking needs. All of this for as little as $90 per month per user! Find out more at www.aim.ca, Email us at [email protected] or call us at 1.866.645.2224 to arrange a software demo Artificial Intelligence In Medicine Inc., 2 Berkeley Street, Suite 403, Toronto, ON M5A 2W3, Canada

Autoscribe Limited (Booth 120a)

ASKION GmbH (Booth 101)

Bahnson Environmental Specialties, LLC (Booth 303)

ASKION GmbH is your partner for modular bio bank system solutions up to completely automated sample handling and storage of biological material at highest quality standards in different sample formats at temperatures < -150 °C.

The ASKION C-line system features ice free storage, an uninterruptable cooling chain for your samples and a complete tracking of all data of the samples, down to each single sample. Open interfaces enable the easy connection to labor / hospital information systems as well as other external devices to the system.

Bahnson Environmental Specialties (BES), an EMCOR Company, located in Raleigh, NC is a leading Controlled Environmental Chamber Manufacturer that provides design, installation, service, & validation of standard or custombuilt Walk-In Controlled Environmental Chambers for close tolerance temp/RH mainly to the pharmaceutical/biotech & research markets. Applications include: High capacity -75°C Cascade low temperature storage and Biorepository chambers, Walk-in Stability, HEPA Filtered Cold & Warm Rooms, Laboratory/ Bulk storage, Vaccine chambers, & in addition to standard incubators, warm rooms, cold rooms & freezers. BES also has a complete line of ES2000 Reach-In Environmental and Photostability Chambers. www.ESchambers.com

AstridBio Technologies Inc. (Booth 314)

BASF/Metanomics Health (Booth 112)

SmartBiobank is a free, online data management application designed to meet research needs by incorporating new technologies like cloud-based data storage and secured data access. The aim of this system is to be able to integrate different types of research data into one single system that is easily accessible. The SmartBiobank team was developed by a combination of experienced IT developers and scientific personnel who aim at providing a highly satisfying

Metanomics Health GmbH – a BASF Group company – applies comprehensive Metabolite Profiling (metabolomics) with biomedical data interpretation. Metabolite Profiling is defined as the parallel analysis of multiple endogenous metabolites in biological systems. The core expertise of Metanomics Health resides in discovery and validation of biomarkers.

The ASKION C-line system offers a bio bank solution, which gives you a maximum of flexibility regarding sample formats as well as storage configuration.

Autoscribe’s solution is a configurable sample tracking system that is applicable to bio-banking and bio-repository management. Our software enables you to manage an ever increasing number of bio-samples (blood, tissue, DNA etc.) and to comply with rigorous regulatory requirements, such as HTA, GCLP, MHRA and national regulations. Samples need to be tracked at all times and it is essential to be able to record the complete genealogy for all samples and track the aliquots, pooled samples and derivatives of each sample. Autoscribe Matrix Gemini is capable of all these things and more.

51 www.isber.org

2014

Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

MxP™ Quality Control Plasma is the first validated assay for holistic human plasma quality control. Its results provide information about the presence of pre-analytical deviations and where they occur in the process. MxP™ Quality Control Plasma identifies samples with insufficient quality and thereby helps maximizing success for clinical biomarker research.

Cryoboxes mean always 10 x 10 to store 23% more samples compared with 9 x 9 boxes, our CryoKING line brings One Inch Revolution which can double your sample storage with half the space and cost.

BioCision (Booth 113)

Corporate Workshop, Tuesday May 21, 16:00 - 17:00

BioCision is the innovation leader in products that improve standardization and eliminate temperature variability in sample handling, storage and transport. BioCision products feature advanced thermal management technology and smart ergonomic design to address and support the workflow needs of bench top processes, bioprocessing and other cold chain logistics. The CoolCell® family of products standardizes cell cryopreservation and are widely used in cell therapy applications. The CoolBox™, CoolRack® and CoolSink® portfolios eliminate variability in sample cooling, (snap)freezing, thawing and short transport. BioCision is committed to setting new standards in precision, consistency, reliability and reproducibility.

BioFortis (Booth 213) At BioFortis we focus on cutting-edge software to empower researchers in biobanking, biomarker discovery, clinical and translational research to make data useful by making data smarter. Our award-winning Labmatrix software offers a holistic, secure and compliant platform for next generation sample and sample data management to meet the demands of biomarker-based trials and translational studies that are the foundation of personalized medicine. Today, Labmatrix is powering these next generation biobanks at pharmaceutical, biotechnology, government, research hospital and academic organizations.

Biolife Solutions (Booth 215a) BioLife Solutions develops, manufactures and markets biopreservation media and high performance thermal packaging products for cells, tissues, and organs. The Company’s proprietary HypoThermosol® and CryoStor® platform of solutions are highly valued in the biobanking, drug discovery, and regenerative medicine markets. BioLife’s products are serum-free and protein-free, fully defined, and are formulated to reduce preservation-induced cell damage and death. BioLife’s enabling technology provides academic and clinical researchers significant improvement in shelf life and post-preservation viability and function of cells, tissues, and organs. For more information please visit www. biolifesolutions.com.

Biologix Group Limited (Booth 108) CryoKING- the leader and complete solution provider in the Biorepository Kingdom. As an ISO, FDA and CE certified manufacturer, Biologix will fit all of your BioBanking needs. Our CryoKING® Cryogenic Line includes Cryogenic Vials, Cryogenic Combo, Cryogenic Boxes, Freezer Racks, Scanner & Software. Biologix CryoKING 2D barcoded cryovials mean the ultimate identification, our CryoKING

Biomatrica Biomatrica provides ambient temperature preservation technologies for DNA, RNA, proteins, cells and entire assays. Our customers include biobanks, laboratories and manufacturers seeking to stabilize patient samples and purified analytes. Biomatrica saves customer’s money by eliminating expensive cold chain storage and shipment of sensitive biological molecules, while protecting sample and assay integrity.

BioMicroLab (Booth 114) BioMicroLab is an innovator of benchtop sample automation instruments which provide drug discovery productivity tools for life science researchers. Our instrument offering helps improve laboratory efficiency by automating tasks associated with sample handling and by integrating multiple laboratory applications onto a single automation platform. BioMicroLab offers researchers three types of sample management productivity systems, these include: (1) volume inspection systems, (2) tube and vial based sorting, weighing, and liquid handling systems, and (3) 2D barcode decoding systems. All of BioMicroLab’s robotic platforms are compatible with SBS standards to ensure integration with other automation oriented robotics and labware.

Biosero, LLC (Booth 203) In addition to developing our own products, we bring together a consortium of companies which provide scientists with products and services for complete laboratory automation solutions. Products include liquid handling, capping and decapping, microplate sealing, hoods and enclosures, integration and scheduling software, robotic automation, and barcode scanning. All are uniquely designed with the highest level of engineering and performance in mind. Our company and our partners have developed proven products based on communication with our customers in the Life Sciences industry including such areas as drug discovery, high throughput screening, proteomics and genomics.

BioStorage Technologies (Booth 216) BioStorage Technologies, Inc. is the leading global provider of comprehensive sample management solutions for the bioscience industry. The company’s unique value is delivered by an expert team of global sample consultants, industry leading temperature-controlled storage facilities, and state-of-the-art virtual sample management and bioprocessing solutions. BioStorage manages the complete lifecycle of outsourced, onsite or hybrid sample management solutions. With an emphasis on quality, compliance and technology, we help companies maximize their research opportunities, minimize risk and reduce costs.

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Brady Corporation (Booth 304) Brady Corporation is an international manufacturer and marketer of highperformance labels, printing systems, software and safety products for a variety of industries around the globe. Brady has been developing durable labeling solutions for the lab market for over 12 years, focusing on specimen identification, tracking & storage applications as well as general labeling and safety applications within the Life Sciences and Industrial laboratory setting. Brady is headquartered in Milwaukee and employs 6,900 people at operations in the Americas, Europe and Asia/Pacific. Brady’s fiscal 2013 sales were approximately $1.15 billion. More information about Brady Corporation is available at www.bradycorp.com.

Brooks Life Science Systems (Booth 211, 310) Brooks provides unparalleled experience in the provision of automated biostorage and sample processing solutions for biorepositories. Suppliers of the first automated DNA and also -80°C stores, Brooks understands the importance of sample integrity and provides a comprehensive range of biostorage solutions from ambient to -80°C. With the largest installed base and support network for automated sample management, Brooks has supplied over 200 stores worldwide. Complementary QC products for volume & precipitate detection, tube & vial handling, REMP, Matri & Aurora consumables are also available. From standardized benchtop systems, to the world’s largest custom installations, Brooks is the name scientists rely on.

caTissue Plus (Booth 419) caTissue Plus is a Free & Open Source Biospecimen Management Software. The core of caTissue is that “biospecimens without high quality data is of no value”. caTissue is used across the globe in some of the most respected biobanks of various sizes and diseases. caTissue streamlines management of biospecimens across collection, consent, QC, request and distribution. Finally, caTissue Plus is highly configurable and customizable. E.g., adding a custom field or form can be done in minutes by a non-IT person. Krishagni actively develops newer versions of caTissue as well provides professional support. Support includes phone/email, data migration, customizations, integrations, training, and so forth.

chemagen from PerkinElmer, Inc. (Booth 317, 416) chemagen a leading supplier of automation and reagents for fast and reliable magnetic bead based DNA and RNA extraction for sample volumes from 10 ul to 10 ml for blood, tissues, saliva, bacteria, food, PCR products. All functions can be performed on the one instrument. Advantages of this unique system are fast processing, unmatched sample volume range and robust chemistry. Visit us at booth # 317/416 for more information about the new chemagic 360

CloudLIMS (Booth 302) CloudLIMS.com is a cloud based laboratory informatics company with a strong focus on data security and compliance. Our flagship products for biobanking

and sample management, use a robust cloud technology platform to give you access anytime, anywhere at virtually zero capex. The cloud based products are offered as Software-as-a-Service (SaaS). Our pay-as-you-go model enables even small and medium laboratories to automate workflows and increase productivity. We offer a complete solution, meeting GLP, HIPAA &FDA guidelines, including 21 CFR part 11 requirements for biobanks, molecular diagnostic labs and pharmaceutical companies.Please visit www.cloudlims.com for a free trial.

Coldstash (Booth 402) Custody of your cryogenically stored specimen is your primary concern. 
Being more efficient in doing that is our concern. Coldstash’s driving force is to create innovative new cryogenic storage, retrieval and delivery solutions that maximize freezer or dewar capacities for greater efficiencies as well as improved workplace performance. Each component in our extensive cryogenic storage product offerings gives you a unique advantage by having the ability to store as much as 35% more samples in the same space. This allows you to maximize valued freezer space for additional cryogenic storage, reduce liquid nitrogen consumption, and lower your energy costs.

College of American Pathologists (Booth 110) As the leading organization for board-certified pathologists, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. With more than 18,000 physician members, the CAP has led laboratory accreditation for more than 50 years with more than 7,500 CAPaccredited laboratories in 50 countries.

Computype (Booth 409a) For over 40 years, Computype has been the primary barcode and tracking solutions resource dedicated to reliable sample & container identification. With our full suite of laboratory offerings such as: Pre-labeled lab ware, tare weighing services, automation of all stages, and barcode labels that survive almost any chemical testing or environment, Computype is your trusty toolkit for improving lab efficiency. Address: Computype, 2285 West County Rd C, St. Paul, MN 55113, 800-328-0852, Email: [email protected], Website: www. computype.com/lifesciences, Twitter: @Computype

Coriell Institute for Medical Research (Booth 411) The Coriell Institute for Medical Research is an independent, non-profit biomedical research center based in Camden, New Jersey. Founded in 1953, the Institute is dedicated to unlocking the genetic code of human disease. The Coriell Biobank is regarded as the most diverse collection of highly-characterized cell lines and highquality DNA, annotated with rich phenotypic data and available to the international research community. Additionally, Coriell is a pioneer in personalized medicine and is exploring the promise of induced pluripotent stem cells – stem cells created from skin or blood – and their role in disease research and drug discovery.

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Cryoxtract Instruments Booth (107, 206) CryoXtract delivers a unique set of instrument solutions to the scientific community to protect biosample integrity, increase the utilization of critical collections, and optimize scientific outcomes. CryoXtract’s proprietary technology allows for the coring of multiple frozen aliquots from a single sample without exposing the parent to multiple freeze/ thaw cycles. CryoXtract will exhibit both the CXT750 automated sample aliquotter and the CXT350 benchtop sample aliquotter systems. Both instruments enable targeted and repeated access to a broad range of tissue and biofluid samples while maintaining their frozen -80oC state. The company will display successful applications in genomics, proteomics, and human gut microbiome.

Custom Biogenic Systems (Booth 111) Custom Biogenic Systems will display a complete range of equipment and accessories for cryogenic freezing and long term cryogenic storage. The -190C ISOTHERMAL DRY STORAGE FREEZER, STANDARD OR CAROUSEL MODEL, controlled rate freezing systems, and Ln2 dry shipping containers. Also displayed will be the NEW VERSALERT ALARM / MONITOR SYSTEM, plus freezer inventory systems for storing any type of sample.

Denator AB (Booth 116) Denator produces instruments and consumables, based on the company’s proprietary sample preservation technology, within the life science and clinical research markets. The Stabilizor™ T1 enables scientists to ensure the quality and in vivo profile of biological samples, by immediate and complete inactivation of enzymatic activity otherwise causing sample change and degradation. Its additive free, and enables reliable analysis and quantification of proteins, peptides and their modifications. It can be used for all tissue types, fresh or frozen, allowing secure analysis also of stored samples. Stabilized samples have improved signal-to-noise ratio, enabling detection of low abundant molecules such as potential biomarkers.

DNA Genotek (Booth 315a) DNA Genotek provides high-quality biological sample collection, stabilization and preparation products for human genetics, microbiology and animal genetics. The company’s products protect and stabilize multiple sample types for long-term storage at ambient temperature to ensure the highest quality results for genetic analysis and testing. The products’ reliability and ease-ofuse have resulted in rapid adoption by thousands of academic, biotechnology, diagnostic, agriculture, and other leading institutions around the globe.

ELPRO Services (Booth 200) ELPRO manufactures dataloggers for biobank facility and in-transit monitoring. Incorporate ELPRO’s fully scalable, redundant wired or wireless system

to monitor equipment such as LN2 tanks and ULT freezers. In addition to temperature, we monitor humidity, O2, CO2, or essentially any parameter. Our Web Access solution allows you to see the status of your system from anywhere without additional software, including your smart phone, tablet, or home PC. For shipment monitoring, the LIBERO PDF in-transit datalogger requires no software or hardware at the destination, and can be easily integrated to your existing dry shippers.

Fisher BioServices (Booth 405, 407) Fisher BioServices, part of Thermo Fisher Scientific, is a professional stem cell and cell therapy services provider. With locations around the world, Fisher BioServices is committed to providing biorepository storage, logistics infrastructure and clinical trial services to the cell therapy industry. Our facilities and capabilities enable us to provide integrated solutions from collection site or CMO to repository or clinical site. Services include biobanking and biorepository, laboratory processing, cold chain logistics, kit production, qualification and validation, and biologic-API management.

Fluidigm Corporation (Booth 115a, 214a) Avoid the embarrassment that comes from having misidentified samples in your biorepository. Fluidigm provides a rapid, simple, and high-throughput SNP genotyping panel that biobanks and biorepositories can use to identify DNA samples and ensure traceability throughout the banking and downstream analytical processes. SNPtrace™Panel is an expertly designed panel using Fluidigm’s SNPtype™ Assays. The BioMark HD™ System and the 96.96 Genotyping IFC, combined with the SNPtrace™ Panel, delivers a cost-effective, easy to deploy, and easy to use workflow to determine or verify uniqueness, gender, and quality of a DNA sample prior to storage or for use in downstream genomic analysis. For more information, visit www.fluidigm.com

Fluidx Ltd (Booth 410) FluidX Ltd. provides innovative solutions for sample storage, tracking and management. Our continuing growth is a result of an ongoing commitment to creative product development, while exceeding customers’ expectations and requirements for the high quality consumables, instrumentation and automation tools needed to help our customers’ succeed in their research.

Freezerworks (Booth 202) Providing configurable sample data management and biobanking software solutions since 1985. Track samples testing, reporting, billing and shipping across multiple freezers and sites while managing biobank workflow. Safeguard data with comprehensive security features, 21 CFR part 11 compliance, and cryogenic-safe bar code and RFID labeling. Web service features assist integration with existing laboratory software and instruments as well as offer a secure option for specimen availability over the web. The Freezerworks configurable LIMS model puts the laboratory in charge, offering adaptability at

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a fraction of the cost. Freezerworks is written and tested according to the FDA General Principles of Software Validation.

Gas Cryo Systems (Booth 118) Store your frozen samples extra safe below -90°c, and give yourself peace of mind with our daihan freezers. We offer a “state-of-the-art“ ult freezer line with 2 totally separated freezing systems and redundancy at -80°c. Our warehouse is located in Clearwater, Florida.

Greiner Bio-One (Booth 205) A world-renowned partner for OEM, drug discovery, and diagnostics, Greiner Bio-One integrates injection-molding expertise with scientific innovation. Precision engineering, premium materials and advanced surface technologies are employed to manufacture an extensive platform range for state-of-the-art methodologies in High-Throughput & High-Content Screening, Cell Culture, Immunology, Biochips & Biobanking. Visit gbo.com.

Hamilton Storage Technologies (Booth 212) Hamilton Storage Technologies provides ultra-low temperature automated sample management solutions for the life science industries. Products include -80°C biobanking and -20°C high-throughput tube and plate management systems. Our systems integrate with Hamilton Robotics’ automated liquid handling workstations for complete biobanking solutions. Our new LabElite™ line of benchtop devices includes an automated decapper, automated 2-D barcode reader and a combination of the two devices to provide flexible solutions for sample processing, tracking and security. Visit us in Booth 212 to learn more! www.hamilton-storage.com

HighRes Biosolutions (Booth 222) We love automation. We design and build innovative robotic systems and laboratory devices used by pharmaceutical and biotech companies and academic research laboratories. HighRes helps scientists accelerate such areas as drug discovery, high-throughput genotyping, siRNA screening, next-generation sequencing sample prep, biorepository science, molecular diagnostics, and more. We offer highly flexible, expandable and modular integrated systems and bench-top devices that are easily configured (and reconfigured) for fast-paced, dynamic laboratories.

Illumina Illumina is a leading developer, manufacturer, and marketer of life science tools and integrated systems for large-scale analysis of genetic variation and function. These systems are enabling studies that were not even imaginable just a few years ago, and moving us closer to the realization of personalized medicine. With rapid advances in technology taking place, it is mission-critical to offer solutions that are not only innovative, but flexible and scalable, with industry-

leading support and service. We strive to meet this challenge by placing a high value on collaborative interactions, rapid delivery of solutions, and meeting the needs of our customers.

BSI Systems /Information Management Services (Booth 307) BSI is a powerful web-based system for biobank specimen management. BSI provides support for tracking all aspects of the specimen life cycle including subjects, consent, specimen acquisition, specimen storage, specimen request processing, and test results data collection in a secure, validated system. Configurable, customizable, and cloud-hosted, BSI provides a feature-rich environment that meet the needs of both large and small biobanks.

IMV Technologies/Cryo Bio Systems (Booth 403) Cryo Bio System is the manufacturer of the .3ml and.5ml CBS High Security Straws and automation. Our range of high security products and automation options can be utilized in a wide range of biorepository, epidemiological and human ART applications. An international presence through subsidiaries in Italy, in the Netherlands, in the United States, in China and in India, and distributors in over 60 countries, offer customers both high quality products and expert technical support. Founded in 1987, Cryo Bio System is a division of IMV Technologies. www.Cryobiosystem-imv.com

ISENET-USA LLC (Booth 412) ISENET-USA LLC (www.isenet-usa.com) is one of the World Leaders in Tissue Microarray Technology. Its Galileo CKxxx Tissue Arrayers are covered by the NIH Licence (US 6,699,710 & EP 2,318,984) and distributed exclusively in the USA by Transgenomic Inc. (www.transgenomics.com). The Galileo TMA are engineered by ISENET Italy (www.isenet.it) and assembled (and soon manufactured) by ISENET-USA LLC in the USA. The Galileo Tissue Microarrayers are available in 4 different models: SemiAutomatic (CK2500 - designed to substitute the manual arrayers); CK3500 and CK4500 (Computer assisted) which can interface with any commercial Digital Scanner (Aperio, Hammatsu, TissueGnostics, etc.).

Kairos GmbH (Booth 414) ‘Kairos’ is headquartered in Bochum, Germany. Its strategic product is the biobanking and trial management system ‘CentraXX’, which allows for the contextualization of sample data within the donor’s clinical history data. These data are collected and compounded from multiple primary IT-sources via interfaces, and made searchable and analyzable, thus significantly raising the value of a biobank’s stock. Using a fully integrated workflow engine, ‘CentraXX’ orchestrates all relevant biobanking work processes in runtime and tailored to the individual actors. A trial management module with automatisms

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for the recruitment of suitable test persons, as well as trial registry and trial documentation functions, is also part of ‘CentraXX’.

KAYE (Booth 305) Kaye trusted products & services help meet all your thermal validation and monitoring needs. Visit the Kaye booth # 305 to find out more about wired and wireless thermal validation systems; wireless process validation and, centralized facility monitoring, alarming and reporting systems. Kaye LabWatch LT is a reliable, cost effective self-configurable solution to automate your continuous monitoring needs. Easy to install and simple to configure, this intuitive system provides continuous real-time monitoring of your critical environment conditions wirelessly and reliably .LabWatch LT is utilizing RF ValProbe wireless sensor technology with SmartMesh network and data redundancy for superior RF performance.

clinic-based control collection (N>35,000 patients), includes deep phenotypic information from the electronic medical record that can be leveraged to meet the needs of a large number of study types and designs.

Mesa Labs (Booth 116a) The ViewPoint centralized monitoring system (CMS) from Mesa Monitoring is the most reliable way to protect valuable product, archive valuable data and receive real-time alerts based on your acceptance criteria. ViewPoint is a networked system that monitors humidity, temperature/humidity, differential pressure, O2, CO2, water detection, air velocity and much more. Saving time and money, eliminating errors, and protecting your facility from costly product loss, ViewPoint helps to keep your facility compliant with FDA, AABB, CAP, DHS, and other regulatory agencies. Contact Mesa Monitoring today to learn more about our ViewPoint real-time monitoring solution.

LabVantage Solutions, Inc. (Booth 102)

Micronic (Booth 104)

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ with offices around the world. We offer a comprehensive portfolio of products and services for the laboratory, including LIMS (Laboratory Information Management System), quality electronic laboratory notebook (ELN), and business intelligence. Our industryleading solutions and world-class services are the result of 30+ years of experience in laboratory informatics. We leverage that know-how with state of the art technology to help organizations redefine and optimize the way their laboratories conduct business. We have a proven track record of delivering return on investment to laboratories of all sizes and time zones. Our capabilities extend to legacy system migration, global laboratory harmonization, and laboratory business intelligence derived from disparate sites and systems. LABVANTAGE delivers the best technical and domain expertise available to help you drive the success of your business. To find out more, visit http://www.labvantage.com.

Micronic is a global manufacturing company headquartered in Lelystad, Netherlands, and with US Sales and Production facility located outside of Philadelphia. Micronic products are manufactured and assembled in Class 7 clean rooms where all products are certified as RNase, DNase and Endotoxin (pyrogen) free. Micronic produces an innovative line of products for traceable sample storage solutions. Micronic’s product line features 2D coded tubes in volumes from 0.5ml to 7.5ml, automation friendly racks, capping options to fit all applications; including TPE capclusters, screw caps, low profile screw caps, code scanners, sample management software and equipment for capping and decapping tubes/racks.

Liconic (Booth 313) Liconic specializes in the design and manufacture of automated plate- and tube stores for storage solutions in laboratories and applications with special climate requirements. Our 20 years of leadership in this field has led to an installation base of several thousands of systems in operation worldwide. By closely working with customers Liconic continually expands its product portfolio ensuring leading edge technology for today and tomorrow

Mayo Clinic Bioservices (Booth 315) Mayo Clinic Biorepositories provides customers with end-to-end services related to collection, accessioning, sample processing, storage, management and distribution. The Biospecimens Accessioning and Processing (BAP) and Pathology Research Cores (PRC), located in a new state-of-the-art 35,000 square foot facility offers a variety of processing services including DNA/RNA extraction, automated fractionation and aliquoting, pathology services, kit building, robotic and standard storage capabilities. The Mayo Clinic Biobank, a

MVE Chart (Booth 201, 300) MVE Chart introduces the HEco™ and MVE Vario™ Series into our line of liquid and vapor stainless steel freezers. We offer a complete range of stainless steel freezers with vial capacities ranging from 3.200 to 94.000. Our vapor units maintain -190˚C at the top storage box and still achieve the longest holding time and lowest LN2 consumption of any comparable freezer on the market. MVE Chart also features a complete line of aluminum storage units including vapor shippers and nitrogen handling equipment.

NHLBI – BioLINCC. Sharing Biospecimens and Data (Booth 413) The National Heart, Lung, and Blood Institute has supported data and biospecimen collection for more than 130 studies. BioLINCC serves to coordinate searches across these collections, and the BioLINCC website provides a mechanism to request data and biospecimens for use by qualified researchers. The website can also be used to submit biospecimen collections to the NHLBI.

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Pacific Bio-Material Management, Inc. Novare Bio-Logistics (Booth 204) Divisions of Pacific Bio-Material Management Inc., Pacific BioStorage and Pacific Scientific Transport are leading providers of cGMP compliant storage, transport and cold chain management of biological materials at any temperature. At Pacific BioStorage, we provide storage solutions and manage valuable biological collections in a secure, cGMP compliant biorepository and provide worldwide logistical support, ensuring the integrity of our client’s material, allowing them to focus on their core competency. Our transportation division, Pacific Scientific Transport (PST), is a leading cold chain logistic service provider, licensed and trained in the legal packaging and transport of regulated chemicals, biological material and hazardous substances. www.pbmmi.com

Panasonic (Booth 314a, 316) Known throughout the world as a leader in consumer electronics and appliances, Panasonic addresses global needs such as energy, food, housing, health and information technology. Here at Panasonic Healthcare, we combine ideas and innovations from our worldwide network of industrial and consumer products into a complete line of biomedical laboratory products. For over forty years, we have established a reputation as a premier manufacturer of precision biomedical and laboratory equipment. Through this effort, we offer the industry’s most sophisticated refrigeration compressor design and state-of-the-art electronics to ultra-low and cryogenic freezers, refrigerators, incubators and environmental chambers.

Praxair (Booth 406) The largest industrial, medical, and specialty gases supplier in North America, Praxair offers a broad portfolio of gas products with the purity, compliance, and certification needed for your cryopreservation, laboratory or research application. We work with users to implement the appropriate supply mode from a complete range of cylinder, dewar, microbulk, and bulk options and help them protect the integrity of their high quality gases with Praxair’s full line of ProStar™ Platinum regulators, manifolds and delivery systems. Praxair’s products and services are making our planet more productive.

Precision Bioservices (Booth 120) Better science begins with better samples. Precision Bioservices will streamline your testing through preparation and pre-qualification of your biological samples. Our quality management system and procedural consistency ensure reliable and meaningful results. Accelerate your research through our custom offerings: • Collection kit design and production • Biological sample processing

• • • • •

Cell Isolations from Peripheral Blood, Cord Blood or Bone Marrow Generation of master and working cell stocks DNA/RNA extractions Highly annotated specimen procurement Sample characterization and integrity assessment using a variety of of immunological techniques

Promega (Booth 215) Promega Corporation is a world leader in applying molecular biology and biochemistry to the development of innovative, high value products for the life sciences. Stop by our booth to learn about our solutions for Biobanking including automated nucleic acid purification from blood and other sample types, nucleic acid quantitation, and sample pre-qualification.

Rees Scientific (Booth 121) For 30 years, Rees Scientific has been the industry standard for automated temperature monitoring. We specialize in monitoring your critical equipment and protecting your valuable assets. Our Presidio Centron Monitoring System is a complete solution to all of your environmental monitoring needs. We monitor critical equipment in repositories and help meet standards for GxP, GMP, FDA, AABB, Joint Commission, 21CFR11, and much more. Rees Scientific will continue to build products and services that help provide resolutions for our customers. Our goal is to be a quality provider of systems, services and solutions for our clients.

RUCDR Infinite Biologics (Booth 117) RUCDR Infinite Biologics is the world’s largest university-based biorepository specializing in custom genomic solutions. RUCDR provides comprehensive services in bioprocessing, genomics, sample analytics and biostorage to government agencies, academic institutions, foundations, and biotechnology and pharmaceutical companies within the global scientific community. By utilizing a state-of-the-art infrastructure and the highest quality biomaterials, RUCDR scientists convert precious biosamples into renewable resources thereby extending research capabilities. RUCDR maximizes the discovery process and protects precious biomaterial resources for future analyses allowing stakeholders to optimize the value of biological assets. Innovative workflows, cutting edge analytical approaches, and robust biomaterial storage processes enhance every collection.

Ruro, Inc. (Booth 312) Headquartered in the heart of Maryland’s Bio Corridor, RURO develops and provides the most modern information management software solutions to more than a thousand laboratories worldwide. RURO systems can decrease staff time requirements for data entry, compilation and reporting by more than a third, and reduce user input errors by up to 97%. RURO is Laboratory Information Bliss™. For more information please visit RURO online at www.RURO.com

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Walt Disney World Swan and Dolphin Resort Orlando, Florida, USA • May 20 – 24, 2014

Scinomix Inc. (Booth 417) Scinomix is a leading provider of laboratory automation systems to customers in the Life Science industry. Our standard line of automated tube and plate labelers will give you significant walk-away time and increase productivity and efficiency in the lab. In addition to offering our own fully automated systems, we also integrate many of our products with other manufacturers’ instrumentation to provide complete solutions for our customers.

Sequenom Bioscience (Booth 118a) Sequenom Bioscience offers the MassARRAY® System, a highly sensitive, quantitative method for nucleic acid detection via MALDI-TOF mass spectrometry. The MassARRAY® System enables rapid assay development for interrogating anywhere from tens to hundreds of biomarkers at a low cost point per sample. Take advantage of Sequenom Bioscience’s family of research use only somatic mutation panels to accelerate translational and clinical research. Select tumor-specific lung cancer and melanoma research panels or the new OncoFOCUS™ Panel for targeted hot spot profiling in EGFR, KRAS, BRAF, and NRAS. Visit booth #118a.

So-Low Environmental Equipment Co., Inc. (Booth 106) Since 1959, So-Low has manufactured Ultra-Low Temperature Freezers for research, storage, and industrial needs. We also supply laboratory freezers, refrigerators, undercounter freezers, and undercounter refrigerators for many different applications. Professionals in 122 countries, all over the world, have recognized the dependability and efficiency of So-Low Ultra-Low Temperature Freezers and Refrigerators. Our goal is to provide a level of quality construction, reliability and value unequaled anywhere in the world for our customers.

Starlims (Booth 103) STARLIMS an Abbott Company, with over 25 years of experience, offers a highly flexible and configurable genetics module, completely integrated with our unified LIMS platform to automate and harmonize your laboratory processes. STARLIMS can process large volumes of data, facilitate regulatory compliance and streamline the sharing of your laboratory data. STARLIMS is a comprehensive solution designed to increase operational efficiency while improving the quality of your specimens and sample data by offering the Automated Tools, Electronic Tracking and Full Scalability. Customers depend on the ability to manage and distribute high-quality specimens.

Stirling Ultracold (Booth 415) Stirling Ultracold manufactures and sells the world’s highest performing ultra low temperature freezers. These units are cooled with an environmentally friendly energy efficient Stirling engine instead of cascade compressors.

They use less than half the energy of any competing unit, have unmatched temperature stability, can be plugged into any electrical outlet worldwide and are manufactured in the USA. At ISBER Stirling Ultracold will exhibit the award winning 27 cu. ft. SU780U freezer.

Taylor-Wharton (Booth 301, 400) Based in Minnetonka, MN, Taylor-Wharton Cryogenics LLC manufactures stateof-the-art CryoScience by Taylor-Whartontm equipment ranging from 1.5 liters to the largest LABS freezer that holds up to 94,200 vials. A complete line of CryoScience laboratory inventory control systems and accessories are available. With worldwide operations and manufacturing facilities, Taylor-Wharton also produces a complete line of liquid cylinders, Microbulk and bulk tank storage systems up to 110,000 gallons. For more information on the complete line of Taylor-Wharton products, call U.S. customer service at 1-251-443-8680 or visit www.taylorwharton.com.

Tecan (Booth 217) Tecan is a leading global provider of laboratory instruments and solutions in biopharmaceuticals, forensics, and clinical diagnostics. The company specializes in the development, production and distribution of instruments and automated workflow solutions for laboratories in the life sciences sector. Tecan offers fully automated solutions for pre-analytical sample handling based on a compact and versatile platform. The Freedom EVO®-based workstation is a modular, front-end automation system with the flexibility to fit into your existing laboratory workflow, taking care of the most labor-intensive and error-prone procedures, including sample sorting, sample volume inspection, centrifugation, decapping and sample aliquoting into plates.

Thermo Scientific (Booth 409) Thermo Scientific is the premier partner in ensuring the sample quality, reliability, and traceability required by biobanks and biorepositories. We deliver the software, equipment, consumables, reagents, and services to provide the end-to-end solution required for today’s rapidly changing organizations. Our integrated turnkey biobanking portfolio encompasses sample preparation and storage to liquid handling equipment, cold storage devices, to Laboratory Information Systems (LIMS). www.thermoscientific.com/biobankingresources

Titian Software (Booth 214) Founded in 1999, Titian Software specializes in sample management, offering software products and consultancy services for improving the efficiency, throughput and data integrity of one’s sample libraries. Its industry-renowned Mosaic™ software optimizes the storage, processing, tracking, and ordering of small and large molecule sample collections. The Mosaic product suite can be a solution for single or multi-site organizations and is currently used by 13 of

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the Top 20 bio-pharma companies. With increasing worldwide demand, Titian Software has presence in Europe, the United States and the Far East to provide its customers with local expertise and support.

TTP Labtech (Booth 207, 306) TTP Labtech, a UK life science company provides high quality, robust and innovative automated laboratory equipment instrumentation to the life scientist to create process efficiencies. It offers products that minimise assay volumes, reduce handling costs in its three product areas; sample management, liquid handling and cell imaging. Biobanking is an integral part of sample management. TTP Labtech provides a high-density biostore (arktic®) for compact and automated -80°C storage of up to 95,000 samples with full sample tracking and rapid retrieval which can fit neatly into a bench-sized space.

TWD TradeWinds, Inc. (Booth 115) TWD is the industry leader in permanent barcode technologies. With manufacturing facilities centrally located in the United States, TWD provides a wide variety of permanently barcoded glass and plastic sample vials, serving the pharmaceutical and life science research community, particularly in compound

management and biobanking. TWD prides itself with superior customer services and highest quality of products.

Vaisala, Inc. (Booth 414a) Vaisala provides high-performance monitoring, measurement and validation systems for regulated and GxP environments. With fail-safe monitoring and alarming of humidity, temperature, CO2, differential pressure and more, Vaisala provides the most reliable solutions and support worldwide. Vaisala’s Continuous Monitoring Systems deliver gap-free data and industry-best accuracy, while the Vaisala Cold Chain solutions reduce the risk of ruined or adulterated vaccines, pharmaceuticals, biologics and other perishable products during distribution. Website: www.vaisala.com

Wheaton (Booth 415a) Throughout its 125 year history, WHEATON® has been dedicated to supporting scientific advances and discovery by providing innovative solutions for the laboratory research, diagnostic and specialty pharmaceutical industries. The company’s expertise in plastic and glass containers coupled with a wide selection of closure systems and custom solutions ensures the secure storage and delivery of science’s most sensitive materials and precious specimens.

59 www.isber.org

Perfectly Preserved. Hamilton guarantees it. Hamilton’s ultra-low temperature automated sample storage solutions maintain the value of your samples. Our products are used for storage of biological samples and compounds for biobanking, forensic, and drug discovery applications.

Visit us at

Booth #212

Visit www.hamiltonsamplecare.com or call 1 (800) 310-5866 to learn more. © 2014 Hamilton Storage Technologies. All rights reserved.

Speakers & Chair Index Acker J............................................. 28 Agrawal L........................................ 28 Akervall J......................................... 28 Albert M.......................................... 28 Aparicio S.........................................24 Barnes M......................................... 30 Bartels P.....................................26, 28 Becker P............................................26 Betsou F.....................................24, 29 Black J.............................................24 Blackburn H......................................26 Bledsoe M................................. 29, 30 Brockton N...................................... 29 Bromley R........................................ 25 Brooks A.......................................... 29 Carpenter J.......................................27 Chisholm R.......................................24 Cong X.............................................27 De Blasio P........................................26 Djaballah H.......................................24 Doms L.............................................26 Dvoskin R.........................................27 Ehmke E............................................26 Frey M............................................. 29

Furuta K.......................................... 28 Gan R...............................................24 Göransson C.....................................26 Gunter E...........................................24 Henderson M..............................24, 25 Hostetter G.......................................27 Hubel A........................................... 28 Hudson M.........................................27 Isasi R.............................................. 29 Kamlage B........................................26 Karvonen C...................................... 29 Khlebnyy E....................................... 28 Kirillova E........................................ 28 Kofanova O.................................27, 28 Kozlakidis Z.................................24, 28 Labib R.............................................27 Lawlor R.......................................... 29 Ledbetter D.......................................24 Lee M...............................................26 Lehman R........................................ 28 Lermen D......................................... 28 Lewandowski D................................26 Litton J.E.....................................25, 29 Lunshof J......................................... 30

Malin B............................................ 30 Marko-Varga G................................ 28 Masui T............................................ 30 McNally J......................................... 29 Mendy M................................... 28, 29 Minegishi N..................................... 28 Moors A.......................................... 28 Morrin H.......................................... 30 Mullins P...........................................26 Nelsen A.......................................... 29 Olson J..............................................27 Posevitz-Fejfár A...............................27 Prokopiev I...................................... 28 Rajasekhar V.....................................27 Rasooly R.........................................27 Riegman P....................................... 25 Robson K......................................... 29 Roehrl M..........................................27 Rondot Radío P................................ 29 Rosati K........................................... 30 Roy M.............................................. 28 Salvaterra E..................................... 29 Sargsyan K....................................... 28 Schacter B..................................24, 25

Shea K........................................24, 27 Shi T................................................ 30 Siefers H.......................................... 28 Siemon J...........................................24 Silver S..............................................27 Simeon-Dubach D............................ 25 Spindler R.........................................26 Steegers C................................. 28, 29 Tassé A...................................... 29, 30 Thomson B...................................... 25 Van Veen E.................................27, 30 Vaught J.......................................... 25 Wagner E......................................... 28 Warner A................................... 29, 30 Watson P......................................... 25 Winkler E..........................................27 Wolf M.............................................24 Woods E...........................................24 Yeung T............................................ 28 Zaayenga A......................................26 Zhang Y......................................24, 27

Gorman J..................................RAT 01 Guan P...................................... RM 13 Hall A...................................... HSR 60 Hall S..........................................RS 03 Hamot G...................................BRS 05 Heaton R..................................BRS 24 Henderson M........................... ELSI 02 Hodgkinson V............................BRS 14 Hogen S.................................... RM 26 Hoskins J...................................BRS 31 Huang C.................................. HSR 36 Jewell S.................................... HSR 62 Jin H...........................................RS 09 Karvonen C................................ HT 01 Kelly V.........................................RS 16 Kofanova O.................................RS 10 Kollis S......................................BRS 18 Kozlakidis Z...............................BRS 01 Kruckeberg K............................ RM 21 Kwon H.................................... HSR 05 Labib R.....................................RAT 05 Larson D.................................. HSR 46 Lawlor R...................................BRS 21 Lazaris A.................................. HSR 33 Lee J.........................................BRS 15 Li H.......................................... HSR 18 Li T............................................BRS 04 Li X........................................... RM 35 Lin A...........................................RS 02 Liu A. . .................................... HSR 06 Liu L............................ HSR 29, RM 14 Liu S........................................ HSR 42 Loffredo C................................ HSR 52 Mandt R....................... RM 36, RM 38 Mann S.................................... HSR 15 Margossian A........................... HSR 51 Martin L......................................RS 14

Mason D...................... HSR 34, RM 22 Matharoo-Ball B....................... HSR 32 Matzke L................................... RM 15 McNally J................................... HT 02 Mews A.................................... RM 19 Miranda L...................................RS 11 Monovich L............................... RM 40 Mook L..................................... RM 16 Morgenweck W......................... RM 06 Noyes L.......................................RS 20 Nussbeck S.................................RS 01 Odeh H..................................... RM 30 Pang J.......................................BRS 34 Pereira S.................................. ELSI 10 Ponko S.................................... RM 20 Prodanovic Z............................ HSR 48 Pruetz B................................... HSR 40 Pugh R....................................EPSR 04 Pumplun E..................................RS 22 Rao A.......................................BRS 12 Rasooly R................................. HSR 14 Rau M...................................... HSR 01 Ravid R.....................................BRS 28 Raymond E.................. HSR 20, RM 03 Resch Z.................................... HSR 08 Robb J...................................... HSR 02 Robson K................................ HSR 47 Rohrer D................................... RM 33 Rosenfeld G............................. HSR 07 Rubinstein Y.R............................BRS37 Rush A..................................... HSR 13 Salman A................................. ELSI 04 Sargsyan K................................RAT 06 Sawyer S.................................. HSR 64 Sharp A.......................................RS 23 Shea K..................................... HSR 39 Shin H.......................................BRS 10

Shin S.......................................BRS 13 Sieffert N................................... HT 03 Simeon-Dubach D......... RM 04, RM 11 Sprigg N.................................. HSR 16 Steinfelder E.............................. RM 23 Sun M......................... BRS 16, HSR 49 Swanepoel C............................ HSR 43 Tarling T................................... HSR 17 Tarn C...................................... HSR 61 Thomson B................................ RM 17 Tolay S..................................... HSR 19 Tran A....................................... RM 28 Valley D......................................RS 21 Valyi-Nagy K.............................BRS 26 Van Rooyen B........................... ELSI 05 Verna N......................................RS 08 VonMenchhofen Z..................... RM 29 Wagner E.................................. RM 09 Wang C.................................... HSR 53 Wang W.................................... RM 31 Wang Y.......................... RM 34, RS 12 Warth R.................................... RM 41 Wease K................................... RM 24 White C.....................................BRS 30 Wiles K.......................... RM 08, RS 17 Withers S..................................BRS 23 Wong G....................................BRS 36 Wu S............................BRS 02, BRS 03 Ye Q......................................... HSR 38 Yeadon T................................... RM 39 Yin L........................................ HSR 22 Yuan M.....................................BRS 07 Zhang X................................... HSR 37 Zhao Y...................................... HSR 09 Zhou H........................ HSR 23, HSR 25 Zhou J......................... HSR 56, HSR 57

Poster Index Abdelhalim I............................. RM 10 Acker J......................................BRS 29 Aibaidula A.............................. HSR 12 Ammerlaan W.............................RS 13 An J........................................EPSR 05 Bahunde F.................................BRS 19 Ball L....................................... RM 27 Barnes M..................................RAT 03 Barr T..........................................RS 06 Betsou F...........................HT 04, RS 19 Bowles D................................. HSR 50 Brooks A.....................................RS 07 Campos A................................ HSR 11 Carithers L............................... HSR 28 Carpenter J................................ RM 32 Chaffin D....................................RS 15 Chakrabarty R........................... RM 05 Chu P....................................... HSR 21 Clark L......................................BRS 32 Cohen Y.....................................BRS 17 Cui D..........................................RS 18 D’Angelo K.............................. ELSI 09 De Blasio P.................. BRS 06, HSR 26 Demchok J............................... HSR 31 Donaldson M............................BRS 22 Dore J.......................................RAT 02 Dowst H.................................... RM 07 Driga A..................................... RM 02 Dry S........................................ HSR 45 Duma B.................................... RM 12 Ellis H....................................... RM 01 Ezzat S..................................... HSR 58 Furuta K................................... HSR 54 Galbraith J................................ HSR 27 Gao Y....................................... HSR 04 Gao Z........................................RAT 04 Geddes T.....................................RS 04

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International Society for Biological and Environmental Repositories