ANEMIA DETECTION in Health Services
path
Guidelines for Program Managers
December 1996
Second edition, December 1996 (First edition, April 1996)
Program for Appropriate Technology in Health 4 Nickerson Street Seattle, Washington 98109-1699 USA Tel: (206) 285-3500 Fax: (206) 285-6619 Internet:
[email protected] WWW: http://www.path.org
U.S. Agency for International Development
This publication was made possible partially through support provided by the Office of Health and Nutrition, Bureau for Global Programs, Field Support and Research, U.S. Agency for International Development (USAID), to the HealthTech: Technologies for Child Health agreement No. DPE-5968-A-00-0025. Second edition reprints in English, French, and Spanish were made possible through the Opportunities for Micronutrient Interventions (OMNI) project, funded by the Office of Health and Nutrition. The opinions expressed herein are those of the author(s) and do not necessarily reflect the views of USAID. Cover Photo: MotherCare Project
Cover Design: Drew Banks
Copyright © 1996, Program for Appropriate Technology in Health (PATH). All rights reserved. The material in this document may be freely used for educational or noncommercial purposes, provided that the material is accompanied by an acknowledgement line.
!!! " We would like to thank the Office of Health/USAID and the World Health Organization for their support of the research, and the drawings provided for this document. In particular, we would like to thank Dr. Ray Yip and Dr. Onno VanAssendelft (CDC, Atlanta, USA); Dr. Richard Guidotti and laboratory personnel (WHO, Geneva, Switzerland); Ms. Rae Galloway (MotherCare, Arlington, USA); Dr. S.M. Lewis (Royal Postgraduate Medical School, London, England) and Dr. Penelope Nestel (OMNI, Arlington, USA) for their assistance. Appreciation is also given for our many colleagues at PATH who provided input on content and presentation of the document. Any errors in the text remain the responsibility of the authors.
Donna Robinett Heather Taylor Cheryl Stephens
Iron deficiency is the most common micronutrient deficiency in the world1 and has far-reaching and serious adverse affects on health. Anemia detection is often used as a screening test for iron deficiency. Because the condition is so widespread, anemia control activities should be an integral part of health care services. These guidelines are intended to help program managers establish anemia detection services or enhance existing services. They include a general overview of the programmatic issues of anemia screening to provide a context for method choice. Existing commonly available anemia detection methods are presented in a standardized format to help managers make appropriate decisions regarding technology selection. Although some technical information is provided about each of the methods, this is only to give the manager an idea about the complexity of tests in relation to personnel training and equipment maintenance needs. For more detailed information about individual technologies, the reader should consult a standard laboratory text. It is also beyond the scope of these guidelines to include the clinical management of anemia, which is well covered in other publications. ! ! Anemia occurs when the total volume of red blood cells (and/or the amount of hemoglobin in these cells) is reduced below normal values, as defined by healthy populations (see charts on pages 2 and 3). Anemia results from one or more of the following processes: defective red cell production, increased red cell destruction, or blood loss.2 There are often multiple causes for anemia. People suffer from both nutritional anemia (impaired red-cell production) and from parasitic diseases such as malaria (red blood cell destruction) and intestinal worms (blood loss).3 Although iron deficiency is the most common cause of anemia, especially among younger children and women of child-bearing age, other nutrient deficiencies, such as folate and vitamin B12, can also contribute to anemia.4 ! ! " Iron is necessary for the synthesis of hemoglobin, which carries oxygen to the body's cells and transports carbon dioxide from the tissues to the lungs. Anemia is a late sign of deficient iron stores.5 Nearly twice as many people have deficient iron stores as have overt anemia.6 Iron-deficiency anemia results in impaired cognitive and motor development in children and decreased work capacity in adults.7 The effects are
particularly severe in infancy and early childhood and probably cannot be reversed by subsequent therapy. In pregnancy, iron-deficiency anemia can lead to perinatal loss, prematurity, and low birthweight.8 Iron-deficiency anemia also adversely affects the body's immune response.9 # ! !$
Nearly one fourth of the world's population is currently anemic.10
All ages and both sexes are affected, but the prevalence of anemia varies by group.
Vulnerable groups include women of reproductive age (because of menstruation), pregnant and breastfeeding women, and children from 6 months to 2 years of age (because of weaning from breastfeeding).
Half the pregnant women in the world are anemic (in developing countries between 55% to 60% of pregnant women are affected vs. 18% in developed countries).11
The prevalence of anemia is the most severe in Southeast Asia where 75% of pregnant woman are affected.12
Anemia is the sole or major contributory cause in 20% to 40% of the half million maternal deaths yearly.13
Approximately 43% of young children are presently anemic.14
Anemia is most commonly detected by measuring hemoglobin (the iron-carrying part of red blood cells) or by determining the hematocrit (the volume of red blood cells in a specified amount of blood). The World Health Organization (WHO) proposes the following cut-off hemoglobin values for anemia:15 Children under 5 years of age
Hb less than (
