Advisa MRI

™

ENGINEERED WITH SURESCAN MRI TECHNOLOGY

I N N O V A T I O N

Advisa MRI™ Leading edge innovation for managing various patient conditions and co-morbidities What should you expect in today’s leading-edge pacing system? A system that SureScan can benefit patients tomorrow as well. The Advisa MRI™ pacing system is designed for safe access to MRI diagnostic imaging with SureScan™ and unparalleled disease insight and management for your patients today. Plus it has the tools to diagnose and manage the co-morbidities they may develop tomorrow. Our most advanced Advisa MRI pacing system provides your patients unsurpassed capabilities. Innovative features like MVP®, OptiVol®, digital diagnostics and a complete suite of atrial therapies.

Innovation, Sophistication, Simplicity. With no compromise.

NO COMPROMISE

No compromise for co-morbidity management today or in the future

SureScan™ is designed for safe access to MRI, an unparalleled diagnostic imaging • F or millions of patients with cardiac devices, MRI scans are unsafe and contraindicated • 5 0%-75% of patients with an implantable cardiac device will need an MRI scan over the lifetime of their device1 • SureScan pacing systems are the first pacing systems – consisting of the pacemaker and leads – that are designed, tested, and CE Mark-approved for use with MRI when used according to labeling.

Managed Ventricular Pacing (MVP®) Intrinsic conduction when you have it, the safety of pacing when you need it. •U  nnecessary right ventricular (RV) pacing increases the risk of Atrial Fibrillation (AF), Heart Failure hospitalisation, and mortality2-4 • The ESC Guidelines state that in the selection of pacing mode and device, “the trend is towards dual chamber pacing with minimisation of right ventricular stimulation” 5 and the ACC/AHA/HRS guidelines also recognised the importance of minimising unnecessary RV pacing • Managed Ventricular Pacing (MVP®) is proven to reduce unnecessary RV pacing by 99%*6,7 •A  strategy of minimising ventricular pacing led to a 40% reduction in the relative risk of developing persistent AF compared to conventional dual chamber pacing4

1.0

Freedom from persistent AF

A pacemaker should not lead to unnecessary right ventricular pacing which has been linked to increased risk of Atrial Fibrillation and Heart Failure, nor should it prevent your patient from undergoing an essential MRI. The Advisa MRI™ pacing system offers technological advances that will not compromise the future care of your patients.

0.9

0.8 Dual chamber minimal ventricular pacing Conventional dual chamber pacing

0.7 0.0

p = 0.009

0.0 1,065

0.5 840

1.0 728

1.5 587

2.0 424

2.5 249

Years from Implant/Patients Remaining

SAVE PACe TRIAL4

3.0 115

s o p h i s t i c at i o n

How many of your pacemaker patients might develop Atrial Fibrillation or Heart Failure throughout their lives?

Jan 2009

P = Program I = Interrogate _ = Remote AT/AF total hours/day

V. rate during AT/AF (bpm) max/day avg/day

Precise and advanced diagnostics in the Advisa MRI™ pacing system provide you a

OptiVol® Fluid Status Monitoring,

clear picture of your patient’s condition, now and as it evolves.

together with the Heart Failure Management Report,8–12† track and monitor fluid changes using intrathoracic impedance measurements.

Mar 2009

P P

May 2009

Jul 2009

P

Sep 2009

P

Nov 2009

P

Jan 2010

I

24 20 16 12 8 4 0

Avg V. rate (bpm) Day Night

Patient activity hours/day

Heart rate variability (ms)

>200

•O  ptiVol can be used to risk stratify your HF patients for more frequent monitoring13,14

100

100 75 50 25 0 >120 100 80 60 200 160 120 80 200 160

• Direct insight into onset, morphology, and termination of arrhythmias

120 80

• CareLink Network allows remote device follow-up by transmitting comprehensive arrhythmia and diagnostic data right to your clinic • Detailed EGM™ Viewer, patient activated EGM storage, displays symptomatic episodes Episode ID#19 Can to RVring (1mV) Date 16-Jul-2009

Patient Mark (Symptom)

A-A (ms)

V-V (ms)

0 >100

Thoracic impedance (ohms) Daily Reference

Time 10:07 7 6 0

Interval Markers

40

Fluid

•A  vailable on Medtronic CareLink® Network, enabling a fluid status check from a patient’s home

•D  aily AF burden helps assess rhythm control

150

OptiVol fluid index is an accumulation of the difference between the daily and reference impedance. OptiVol fluid index OptiVol threshold

•O  ptiVol automatically monitors fluid status to predict worsening Heart Failure13,14

information for detecting atrial arrhythmias and for rapid decision making. • 1 4 months of trended data helps monitor results of device and drug therapy changes