JF Antaki, pg 1 of 62

CURRICULUM VITAE James Francis Antaki, PhD Carnegie Mellon University Department of Biomedical Engineering 700 Technology Drive, Suite 4321 Pittsburgh, PA 15213 412/802-6431 Birth date: June 7, 1963 Birthplace: White Plains, NY Personal and Professional Objectives:  To improve the quality of life of citizens suffering from debilitating diseases.  To develop methodologies for optimal design of medical devices.  To develop algorithms for optimal delivery of cardiac care and improve patient engagement.  and much more… Personal Statement The majority of professional career has been devoted to development of blood-wetted medical devices. Equally important as the devices themselves, my research focuses on the methodology by which they are designed, and used clinically. For example, my group was one of the pioneers in physiological feedback control of implanted ventricular assist devices. We also developed one of the first decision support programs for identifying heart failure patients who could potentially recover with the acute mechanical circulatory assistance. Over the past 24 years, I have contributed to the development of several heart-assist devices used clinically, including the Heartmate-II, Novacor, Ventracor, TandemHeart, and Levacor. In 1997, I directed a multidisciplinary team that produced the Streamliner heart-assist device – the world’s first magnetically levitated rotodynamic blood pump to be tested in-vivo. The current emphasis of my research involves five application areas: circulatory support systems for children, decision-support tools for severe heart failure, diagnostic technology for the home and point-of-care to improve patient engagement, multi-scale modeling of thrombosis in artificial circulation, and development of medical devices for global health. A nascent, overarching project aims to accelerate medical innovation by professional networking between physicians, medical product designers, and patients. In summary, although my interest and experience is diverse, they share a common theme of improving healthcare though biomedical engineering. Thank you. ACADEMIC APPOINTMENTS & PROFESSIONAL EXPERIENCE 8/2015 – pres. 2009 – pres. 2007 – pres 2008 - pres 2006 - pres 2003 – 12/2005 2003 - pres 2003 - 2008 2003 - 2008. 11/2003 - 2008 1996 - pres 1997 - 1999 2001-2003 1993 - 1999 1991 - 1999

Adjunct Research Professor, AHN Research Institute (AHNRI) Chief Scientific Advisor, Tropical Health Systems, LLC (dba AccelDX, LLC) VP Biomedical Engineering, Falcongenomics, Inc. Professor (adjunct), Surgery, University of Pittsburgh, PA. Professor, Biomedical Engineering, Carnegie Mellon University. Associate Professor, Biomedical Engineering, Carnegie Mellon University. Associate Professor (courtesy), Computer Science, Carnegie Mellon University. Associate Professor (adjunct), Surgery, University of Pittsburgh, PA. Associate Professor (adjunct), Bioengineering, University of Pittsburgh, PA. Chief Creative Officer, LaunchPoint Technologies, LLC. President, AntakaMatics, Inc., Pittsburgh, PA Assistant Professor of Bioengineering, University of Pittsburgh, PA. Lecturer of Engineering in Medicine, Biomedical Engineering Program, Carnegie Mellon University, PA. Director of Artificial Heart Research & Development, McGowan Center for Artificial Organ Development, University of Pittsburgh, PA.

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1991 - 1999 1991 - 1999 1987 - 1989 1985 - 1991 1985 1984 - 1985 1984 1983 1981 - 1982 1977 - 1982

Assistant Professor, Department of Surgery, School of Medicine, University of Pittsburgh, PA. Adjunct Assistant Professor, Department of Mechanical Engineering, School of Engineering, University of Pittsburgh, PA. Clinical Engineer, Presbyterian University Hospital, Artificial Heart Program, Pittsburgh, PA. Graduate Researcher, Department of Surgery, School of Medicine, University of Pittsburgh, PA. Machine Designer, Mikron-Haesler, SA, Boudry, Switzerland. Mechanical Designer, Factron, division of Fairchild-Schlumberger, Troy, NY. Assistant Mechanical Designer, Center for Manufacturing Productivity, Rensselaer Polytechnic Institute, NY. Surveyor, Port Authority of New York and New Jersey, Risk Management Division, Journal Square, NJ. Assistant Manager, Hawthorne Auto Parts, Hawthorne, NY. Freelance TV and radio repairman. Freelance auto mechanic.

RESEARCH ACTIVITIES Mechanical Circulatory Assistance (1991 - present): This is a unifying theme throughout my research career. It has entailed multifaceted, multi-disciplinary research that has culminated in the development of the world’s first implantable magnetically-levitated ventricular-assist device, named the Streamliner. In many ways, this project was analogous to a moonshot, inasmuch as the underlying physics and physiology were unknown at the time of its inception, but had to be developed. Accordingly, it had spawned research into the interaction of blood with artificial materials under extreme flow conditions, feedback-control algorithms to regulate the hemodynamics of implanted devices, novel cannulation strategies, and other peripheral spinoff programs. A novel aspect of this research is the concept of coupling numerical optimization with computer simulation to achieve superior safety and efficacy without the time-consuming and costly demands of trial-and-error. In 1998, the Streamliner became the first maglev rotary pump to be implanted in animals. In 1999, this research was recognized by IEEE who granted their annual Control Systems Award to Antaki and BE Paden. Since 1999 to present day, this work has evolved into development of next-generation magnetically levitated blood pumps, including the Levacor (WorldHeart, formerly MedQuest), the PediaFlow for infants, and the HemoGlide for young children. The Pediaflow program, a collaboration between UoP, CMU, CHP, WorldHeart, and LaunchPoint is currently entering Y2 of a 4-year NIH contract to begin clinical trials in 2012. Decision Guidance System for Mechanical Circulatory Assistance (2001-present) - to optimize ventricular assist device (VAD) as destination therapy (DT) in treating end-stage heart failure. This project, titled CORA: Cardiac Outcomes Risk Assessment – a Virtual Counsellor for Severe Heart Failure, aims to develop a web-based application that supports key decision points in the course of treatment. The application provides physicians with prognostic assessment based on a fusion of patient-specific data, expert knowledge, and retrospective meta-analysis. The patientfacing portion of this project aims to improve engagement in their decision making through education and alignment of treatment strategies with their core values and personal needs. Breast Palpation Aid for Home and Primary Care (2013-pres.) Based on current incidence rates, one out of every eight women born in the United States today will develop breast cancer at some time during their lives. Despite advances in imaging technologies and clinical practice, breast cancer screening has shown an inconsistent impact in decreasing breast cancer-associated deaths while accumulating nearly $8bn in associated annual costs. This project aims to address shortcomings of breast self-examination and mammographic screening with a cost-effective, sensitive, easyto-use palpation aid, PalpAid™ for the home and point of care. PalpAid™ targets both clinical and home settings: both for initial screening and subsequent monitoring of palpable breast lesions. Successful employment of the PalpAid™ device would help educate and empower patients and reduce over-treatment of breast lesions through costeffective monitoring in the home.

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Multi-scale Model of Thrombosis in Artificial Circulation Blood Rheology, Trauma, and Thrombosis (1991-present): This has been a collaborative effort with Dr. Kameneva (University of Pittsburgh) to develop a multi-scale mathematical model to describe and predict the trafficking of blood cells, primarily in artificial circulation, but also in the cardiovascular system. Micro-scale computer simulations and experiments of individual cells are used to motivate and calibrate meso- and macro-scale simulations that may be used in the design of blood-wetted devices. It is currently supported by a 5-year R01, entering its third year. Devices for the Treatment and Diagnosis and Treatment of Malaria. This research represents an amalgamation of our expertise in microfluidics, blood rheology, and magnetics to develop devices to selectively isolate malaria-infected red blood cells. This involves a novel blood filtration system, mPharesis™ (malaria-apheresis) and a point-of-care diagnostic test, pScreen™. This is currently supported through a supplemental award from NIH through the ARRA program. Identifying and Optimizing Ventricular Function and Recovery (1985-pres): The prospect of developing a “cure” for heart failure is a holy grail for medicine. It is likely that future efforts to “remodel” or restore the diseased heart will entail some form of temporary mechanical circulatory assistance – while adjuvant therapies are provided, or the heart recovers by itself. This research aims to (1) develop diagnostic tests that can identify which patients are likely to benefit from temporary cardiac support, and (2) develop strategies to optimize ventricular “reloading” to provide maximal rehabilitative effect. This project is supported by a 5-year R01 to UoP (lead), CMU, U Maryland and Integris Health Systems, now entering its 4th year. Assessment of Right Ventricular Function in LVAD patients (1985-present): An important risk factor associated with LVAD therapy is right ventricular failure. This research dates back to the very first LVAD clinical trials at UPMC, in which Sonomicrometry crystals were implanted at the time of LVAD insertion allowing RV function to be assessed before and after LVAD support. The present day incarnation of this project involves the study of risk factors that can Capsule Summary of Contributions  1987: Conducted one of first clinical studies of right ventricular function in LVAD patients.  1988: First biomechanical study of capsular contracture.  1990: Invented fiduciary markers for tracking cardiac motion with MRI.  1992: First introduction of shape optimization to design of blood-wetted artificial organs.  1994: First concerted research study of ventricular cannulation. First article published on this topic.  1994: Introduced in-vitro vascular perfusion system based on feedback-controlled regulator.  1995: First patent specifically related to control of rotary blood pumps.  1995: Introduced theory of “accumulated damage” for shear-induced blood trauma.  1996: Introduced shoe-generator design for powering artificial organs.  1996: First use of liquid crystal for measurement of viscous shear.  1998: Streamliner Heart-Assist Pump – first maglev rotary pump to be implanted in animals.  1998: Introduction of concept of multi-objective control of rotary blood pumps.  1990-9: First study of physiology and physics of harmonica playing.  1998: First electric/acoustic harmonica.  2003: Introduction of use of Expert System for decision support of artificial heart patients.  2009: Lead project team to develop world’s smallest maglev blood pump (for infants, children, and adults)  2013: Introduced the first breast palpation aid for use at home. identify patients most likely to benefit from bi-ventricular support. PATENTS PENDING 1.

Blank, M and JF Antaki. Breast palpation device for point of care and home use. Provisional filed 6.1.2014.; Utility patent filed 6/24/2015

2.

Gandini, Alberto, et al. "Devices and Methods for Detection and Quantification of Immunological Proteins, Pathogenic and Microbial Agents and Cells." U.S. Patent Application 14/148,010.

JF Antaki, pg 4 of 62

3.

William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Extracorporeal ambulator assist lung. WO 2014085620, Priority Date: Nov 28, 2012.

4.

Burgess JE, and JF Antaki, “Method and Apparatus for the Containment of a Surgical Site, US 20120330271 A1, filed Feb 1, 2012.

5.

Verkaik, J, JF Antaki, and J Martin. Conformal Cannula Device and Related Methods. US 2012/014341 A1, filed Aug 3, 2011, Published June 7, 2012

6.

Antaki, James F., Bradley E. Paden David B. Paden Michael R. Ricci Shaun T. Snyder Josiah E. Verkaik, Magnetically-levitated blood pump with optimization method enabling miniaturization, EP 2340067 A2, Publication date Jul 6, 2011, Filing date, Sep 24, 2009, Priority date Sep 26, 2008. Also published as US20110237863; CA 2738638 A1

7.

Ricci, Michael, R.; Antaki, James, F.; Verkaik, Josiah, E.; Paden, Bradley, E.; Snyder, Shaun, T.; Paden, David, B. (WO/2010/036815) magnetically-levitated blood pump with optimization method enabling miniaturization, 4.1.2010

PATENTS ISSUED 1.

Antaki, JF. Musical Notation and Method of Teaching Same. Filing date: Aug 11, 2012. US 8664503, Issued Mar 4, 2014

2.

Antaki, JF. Methods and Devices for Muting a Harmonica. Filing date: Apr 19, 2013, US 889 5825, Issued Nov 25, 2014

3.

Antaki JF, Pitch Altering Mechanism For Reeded Instrument, US 8802949, Priority date: Aug 13, 2010, Issued, August 12, 2014.

4.

Antaki JF, Improved Musical Notation And Method Of Teaching Same, US8664503, Priority Date: August 12th, 2010, Issued March 4, 2014

5.

Gandini A, and JF Antaki. Device and method for detection and quantification of immunological proteins, pathogenic and microbial agents and cells. US 8623596, Publication date, Jan 7, 2014, Filing date Apr 15, 2013, Priority date Sep 26, 2011

6.

Gandini, A, and JF Antaki. Device and method for detection and identification of immunological proteins, pathogenic and microbial agents and cells. US 8445192 B2G Publication date May 21, 2013; Filing date: Nov 26, 2012; Priority date: Sep 26, 2011

7.

Gaspard, S, M. Siegal, T Przybycien, J Antaki, D Brienza, M Friedman, Medical Device for Diagnosing Pressure Ulcers. Filed 11/27/2008, issued 02/14/2012, US Patent 8116838

8.

Antaki J., J Ludlow, and S Miles. Low profile inlet for rotary blood pump. US Patent 7,338,521 Filed ca. 6/2002, Issued March 4, 2008. also published as: EP1534358A2, EP1534358A4, EP1534358B1, EP1534358B8, US20030233144, WO2003106840A2, WO2003106840A3,

9.

Capone; CD; RC Dempsey; MS Heilman; SA Kolenik; DR Moore; CM Parisi; EK Prem; RA Sofranko; DC Borzelleca; GW Burgreen; JA Holmes; Z Wu; RS Hebbert, JF Antaki. Touch Down of Blood Pump Impellers. US Patent 6761532, 7/13/04, Filed 3/14/2002 [assigned to Vascor, Inc.]1.

10.

Antaki JF. Enhanced Harmonica. US Patent 6,635,814 Filed 1/28/2002, Issued 10/21/2003.

11.

Johnson GA, JF Antaki, JA Magovern, MR Frushell, TD Will, JA Holmes. Hard or Soft Tissue Closure. US Patent 6,485,504, Filed 6/22/2000 [assigned to Cardiac Assist Technologies, Inc.], Issued 11/26/2003

12.

Antaki JF, BE Paden, GW Burgreen, NJ Groom. Blood pump having a magnetically suspended rotor. US Patent 6,447,266 Filed 4/24/2001, Issued 9/10/2002.

13.

Antaki JF, BE Paden, GW Burgreen, NJ Groom. Magnetically suspended miniature fluid pump and

1 This was a blatant, unabashed copy of an invention by Antaki and Paden by Vascor, Inc.

JF Antaki, pg 5 of 62

method of designing the same. US Patent 6,447,265 Filed 9/20/1999, Issued 9/10/2002. 14.

Bearnson GB, PS Khanwilkar, JW Long, JC Ludlow, BE Paden, C Chen, DB Paden, DB Olsen, JF Antaki, PE Allaire, M Baloh. Pump Having a Magnetically Suspended Rotor with One Active Control Axis. US Patent 6,394,769 Filed 6/23/2000, Issued 5/28/2002 [assigned to MedQuest, Inc.].

15.

Antaki JF. Enhanced Harmonica. US Patent 6,359,204 Filed 2/2/2000, Issued 3/19/2002.

16.

Antaki JF. Harmonica having reed vibration conversion capability and associated retrofitting method. US Patent 6,326,532 Filed 12/2/1999, Issued 12/4/2001.

17.

Antaki JF. Harmonica Enclosure. US Patent 6,291,751 Filed 10/2000, Issued 9/18/2001.

18.

Antaki JF, J Greenberger, P Schauer, JA Holmes. Apparatus and a method for automatically introducing implants into soft tissue with adjustable spacing. US Patent 6,270,472 Filed 12/1998, Issued 8/7/2001.

19.

Antaki JF, BE Paden, GW Burgreen, NJ Groom. Blood Pump Having a Magnetically Suspended Rotor. US Patent 6,244,835 Filed 7/19/1999, Issued 6/12/2001.

20.

Antaki JF, GW Burgreen. Rotary Pump Having a Bearing Which Dissipates Heat. US Patent 6,093,001 Filed 6/1/1997, Issued 7/25/2000.

21.

Antaki JF, JR Boston, S Choi, K Butler, D Thomas, D Amin. Speed Control System for Implanted Blood Pumps. US Patent 6,066,086 Issued 5/23/2000.

22.

Antaki JF, BE Paden, GW Burgreen, NJ Groom. Magnetically Suspended Miniature Fluid Pump and Method of Making the Same. US Patent 6,015,272 Filed 6/26/1996, Issued 1/18/2000.

23.

Antaki JF, JR Boston, S Choi. Speed Control System for Implanted Blood Pumps. US Patent 5,888,242 Filed 9/1996, Issued 3/30/1999.

24.

Antaki JF, HS Borovetz, RF Labadie. Fluid Delivery Apparatus and Associated Method [Computer controlled apparatus for perfusing blood vessels to arbitrary hemodynamic loads]. US Patent 5,537,335 Issued 7/16/1996.

ADDITIONAL INVENTIONS (not patented) 25.

Heilman M, C Capone, C Parisi, R Sofranko, D Moore, E Prem, S Kolnik, J Antaki, B Paden, D Borzelleca. Method and Apparatus for Providing Limited Back-Flow in a Blood Pump During a NonPumping State. US Patent Application Filed ca. 4/3/2002 [assigned to Vascor, Inc.].

26.

Kameneva MV, JF Antaki. Denucleation of blood contact materials and surfaces. US Patent Application Filed 2/25/2000.

27.

Antaki JF, RK Meyer. Liquid Crystal Shear Sensor for Viscous Flows. US Patent Application 60/144,444 Filed 7/1999. Device for self-examination of breast lesions. (2013) Integrated Blood Pump-Oxygenator and Method of Designing Same (Submitted to University of Pittsburgh tech transfer office 8/1997). Improved Means for Detecting Cardiac Rejection (ca. 11/1995). A Bio-Compatible Ferro-fluidic Seal (ca. 11/1995). Gait-powered battery charging system for augmented artificial organ power supply -- uses piezoelectric array within midsole of shoe (Recipient of ASAIO/Medforte Innovation Award, 1995). Ventricular cannula for left ventricular circulatory assist -- prevents myocardial collapse, maximizes patency (included in US Patent pending) (1992). Harness for management of electrical and fluid lines for use with chronic in-vivo experimentation (1992). Microencapsulated myocardial marker --- 3 mm diameter microencapsulated copper sulfate ampule, used for fiduciary landmark in cardiac NMR imaging (1990). Surgical insertion tool for myocardial marker implantation -- vacuum operated tool for accurate placement of myocardial markers (1990). Polar cylindrical dissecting fixture for myocardial dissection -- allows accurate dissection of myocardial

28. 29. 30. 31. 32. 33. 34. 35. 36. 37.

JF Antaki, pg 6 of 62

38. 30. 31. 32. 33. 34. 35. 36. 37. 38.

specimens from ventricular free wall in-vitro (1990). High-performance three-dimensional piezoelectric transducer for sonomicrometry -- allows rapid placement and alignment for obtaining three-dimensional myocardial displacement measurements (1989). Apparatus for palpating silicone implants in rodents -- used to quantify degree of capsular contracture (1988). Improved piezoelectric transducer for sonomicrometry -- incorporates guide suture for rapid placement of one-dimensional transducer (1987). Insertion tool for piezoelectric transducer crystal -- facilitates insertion and placement of one-dimensional sonomicrometry crystal (1987). Automated machine part loading assembly -- for rapidly and accurately loading hydraulic connector blanks from parts hopper into rotating vice turret (1985). Circuit board test fixture -- automates process of loading circuit board to test station (1984). Improved epoxy applicator for automatic filament winding (1983). High torque screwdriver (1982). Locking electrical plug -- prevents accidental disconnection from wall receptacle (ca. 1981). Automotive regenerative braking and suspension system (ca. 1981).

EDUCATION Institution University of Pittsburgh Pittsburgh, PA Rensselaer Polytechnic Institute, Troy, NY

Degree PhD QPA: 3.78/4.0 BS Minor QPA: 3.7/4.0

Year Conferred 1991 1985 1985

Field of Study Mechanical Engineering Mechanical Engineering Electrical Engineering

ADDITIONAL EDUCATION AND TRAINING 1997

Introduction to Process Mapping. University of Pittsburgh Human Re

Sources, Pittsburgh PA. 1995

Magnetic Bearing Design - Short course, Dr. Paul Allaire and Dr. Eric Maslen, Alexandria, VA. Advanced AutoCAD Techniques - Short course, Doug Salah, Pittsburgh PA.

1993

Applied Three Dimensional Analysis of Turbomachinery. Short course, CETI, Norwich, VT. How to be a Better Team Leader. Short course, Padget Thompson. Management Problems for the Technical Person in a Leadership Role. Short course, Pryor.

1992

Seminar: Managing Multiple Projects, Objectives, and Deadlines. Short course, Skillpath.

1990

Pittsburgh Supercomputing Center, Fall Visualization Workshop, 2-day seminar, Pittsburgh, PA. Motion Control Made Easy. 1-day seminar, Dr. J. Tal, Galil Motion Control, Inc., Farmington Hills, MI. How to Be the Best Possible Boss. Pagett Thompson, Pittsburgh, PA.

1989

ASYST 1-day Seminar on Data Acquisition & Control, Data Reduction and Analysis, DataPresentation and Graphics. Managing Multiple Demands. 1-day seminar, Ed Stetser, Pittsburgh, PA.

1988

Cardiac Transplantation Workshop. B. Smith, Clinical Instructor, Presbyterian University Hospital, Pittsburgh, PA. Total Artificial Heart (Jarvik 7-70, 7-100). Surgical ICU Nurse's Workshop, Pittsburgh, PA. Biofluid Mechanics/Cardiovascular Dynamics. 40th Annual Conference in Medicine and Biology, Deter Liepch and Stanley E. Rittgers.

JF Antaki, pg 7 of 62

1987

Symbion Total Artificial Heart Workshop (Jarvik 7-70, 7-100 TAH). Operator's Workshop, S. Langsford, Symbion, Inc., Pittsburgh, PA. Novacor Left Ventricular Assist System (LVAS) Operator's Training. Workshop, Philip Miller, Director, Biomedical Engineering, Novacor Medical Corporation, Pittsburgh, PA.

TEACHING EXPERIENCE F13, F14, F15

BME 42-699 Inventive Problem Solving in Biomedical Engineering

Fall 2009, 2010, S14

BME 42-444 Medical Devices

Fall 2009, 2010

BME 42-401: Foundations of Biomedical design (1st part of capstone course)

Spring 04 – S11

BME 42-402 (was 401): Bioengineering Senior Design (capstone course.)

Spring 2001 - 2003

BIOE-1161: Bioengineering Senior Design - II.

Fall 2000 - 2002

BIOE-1160: Bioengineering Senior Design (“capstone” course in Bioengineering).

Fall 1997

BME: Cardiovascular Organs Replacement (with HS Borovetz).

Fall 1996

BME: Cardiovascular Organs Replacement (with HS Borovetz).

Spring 1996

BME: Quantitative Cardiovascular Physiology.

Fall 1995

BME: Cardiovascular Organs Replacement (with HS Borovetz); Bioprinciples (with WR Wagner).

Fall 1992, 1993, 1994

BME: Introduction to Biomaterials (with WR Wagner).

Spring 1993

BME: Artificial Organs: Artificial Heart (with HS Borovetz).

Fall 1992

BME: Introduction to Biomechanics: Cardiac Mechanics.

Fall 1991

ME2060: Introduction to Biomechanics: Blood Rheology; Cardiac Biomechanics; Artificial Heart.

GRADUATE STUDENTS SUPERVISED Active

1.

NAME; Thesis Title Jennifer A. Hayden*

Department CMU-BME

2.

Andrea “Blue” Martin*

CMU-BME

3.

Molly Blank*

CMU-BME

(Expected) Completion Date 5/2014

Degree PhD

12/2014

PhD

5/2014

PhD

Starting Date (Degree) 1/2012 (MS)

Completion Date 5/2015

Degree PhD

B.S., Refrigeration and Cryogenics

5/2015

PhD

Starting Date (Degree) 9/2011 (MS) 9/2011 (BS) 9/2011 (MS)

STUDENTS ADVISED – Graduated/Completed {reverse chronological} NAME; Thesis Title Natasha Loghmanpour* Decision Support System for End Stage Heart Failure Wei-Tao Wu Theoretical and Computational Studies

Department CMU-BME

CMU-ME

JF Antaki, pg 8 of 62

on Thrombosis Growth and Multiphase Characteristics of Blood Flow

Amanda Daly [PhD] BME (UPitt), Experimental investigation of mechanical blood damage relevant to the operation of circulatory-assist devices Ipek Sariouglu

BME (Pitt) co-advised with M. Kamenva

CMU-BME

Engineering, Xi'an Jiaotong University (2011) M.S., Mechanical Engineering, Carnegie Mellon University (2013) 1/2008

9/2011 (BS) 9/2010 (MS-ME)

4/2015

PhD

(5/2013)

MS

CMU-BME (5/2012) MS Ahbinav Singhal [Magnetic Separation of Malaria Infected Blood] CMU-BME 12/2008 (4/2012) PhD Jeongho Kim* [Computational Optimization of (MS) Blood-Wetted Medical Devices] CMU-BME 12/2008 (12/2011) PhD Yajuan Wang* [Decision Support System for (MS) Ventricular Assistance] CMU-BME 12/2008 (12/2011) PhD Matthew Oberdier* [Biomechanics of aqueous immersion (MS) surgery.] CMU-BME 8/2004 (MS) (4/2011) PhD Sanna Gaspard Development of hydrostatic hemostatic surgical system. CMU-BME 9/2001 9/20/2010 PhD Samuel J Hund* A Computational Model of Platelet (MS) Mediated Thrombosis for the Evaluation and Design of Medical Devices. CMU-BME 8/2005 5/2009 PhD Warren C. Ruder* Predicting in vivo Stem Cell Behavior (MS) using Characterization and Analysis of Stem Cell Intracellular Calcium Response to Mechanical and Chemical Stimulus Pitt-BME 9/04 (4/10) Dorian Arnold Circulatory Simulator for Pediatric (BS) MS Applications CMU-BME 1/08 10/10 PhD Dennis Trumble* Development and Testing of a Muscle(MS) powered Cardiac Assist Device *-doctoral student Pre 2008 Department, [co-Advisor] Starting Date (Degree) – Dissertation Date (Degree) 1. Arielle Drummond, PhD (BME, CMU) Surgical Simulation System for Pediatric Heart-Assist System. 9/2004(BS)-12/2008. Currently employed at Medtronic, Inc., Danvers, MA. 2.

Rui Zhao, PhD (BME, CMU) Experimental and Theoretical Investigation of Blood Flow Dynamics Associated with Blood Contacting Devices 1/2005(MS)-9/2008(PhD)

JF Antaki, pg 9 of 62

3.

Timothy Bachman, MS (BME, Pitt), Development of Ventricular Cannula for Mechanical Circulatory Support, 9/2004 (BS)-9/2008.

4.

Antonio Luiz S. Ferreira, An Anti-Suction Rule-Based Control System for Rotary Blood Pumps. Electrical Engineering (UoP) [co advised with JR Boston], 2005(MS) – 2007 (PhD)

5.

Shao Hui Chen, Baroreflex-Based Physiologic Control of A Lef Ventricular Assist Device, Electrical Engineering (UoP) [co advised with M Simaan], 2005(MS) – 2006 (PhD)

6.

Bronwyn Uber, Decision aid to determine the necessity of right ventricular support for patients receiving a left ventricular assist device, 9/2004, 3/29/2006.

7.

Linda Santelices, Development of Expert System for Optimal Care of Patients with Mechanical Circulatory Support, Bioengineering (UoP) 09/2002 (BS) – 07/2005 (MS).

8.

Samuel J Hund, MS (BME), [Computational Fluid Dynamics Optimization of Blood Flow.] 9/02 – 7/05

9.

Rui Zhao, MS (BME: UoP), [Multiscale Model of Blood Damage], 7/02 – 12/04

10. Erik N Sorensen, PhD (BME) Computational Model of Platelet Mediated Thrombogenesis in Artificial Organs, 1997-10/2002. [Currenltly employed by University of Maryland Medical Center (Baltimore, MD) as coordinator of artificial heart program.] 11. George Yanulis, MS (BME): Development of Bioprosthetic Diaphragm Assist Device, based on Polymetric Artificial Muscle, 2001-4/2002 [professional Masters.] 12. Rebecca Gottleib-Meyer, PhD (BME),: Development of Liquid Crystal Technique for Direct Measurement of Blood Shear Stress. 1995-3/14/2001. [Currently employed by Medtronic-Minimed (Irvine, CA) as Research Manager for the Sensor R&D Division.] 13. Leonardo Baloa, PhD (EE): Certainty-Weighted System for the Detection of Suction in Ventricular Assist Devices (co-advisor: JR Boston, EE Department). 1997-1/19/2001 [Senior Engineer, Respironics, Inc.] 14. Seongjun Choi, PhD (EE) Modeling and control of left ventricular assist system. 1997-12/1998 (coadvisor, JR Boston) [Faculty, University of Seoul] 15. Alison Curtis, MS (BME),: A Multiple Modality Study of The Hemodynamics of Left Ventricular Apical Cannulations. 1997-11/20/1998. [Senior Engineer, Edwards Life Sciences] 16. Yih-Choung Yu, PhD (EEng),: Minimally Invasive Estimation of Cardiovascular Parameters. 1996-5/1998 (co-advisor: JR Boston) [Professor, Lafayette College] 17. Krishna K. Yeleswarapu, PhD (MEng),: Evaluation of Continuum Models of Characterizing the Constitutive Behavior of Blood. 1991-5/1996. [Entrepreneur] 18. Beichang "Bert" He, PhD (CEng), [Carnegie Mellon Univ.]: Shape Optimization of Navier Stokes Flows with Application to Artificial Heart Components (primary advisor: Omar Ghattas). 1992-5/1996. [Senior Engineer, General Electric] 19. Jeffrey L. Williams, MS (BMEng),: Starling-Responsive Mock Circulatory System for Left Ventricular Assist Controller Development. 1992-5/1995. [Attending Physician, Cardiology] 20. Tammy J. Dennis, MS (Meng),: Experimental and Theoretical Approach to Design of Artificial Heart Cannula. 1992-1994. [Attending Physician] 21. Darryl Breitenstein, MS (EEng),: Simulation of the Cardiovascular System for Model-Based Algorithm of Artificial Heart Control (co-advisor: JR Boston). 1992-1993 22. Mark J. Gartner, MS (Meng), [CMU]: Computational Fluid Dynamics (CFD) Investigation of Blood Flow Within The Outflow Region of A Left Ventricular Assist Device. 1991-1992. [Entrepreneur, President, Ension, Inc.]

JF Antaki, pg 10 of 62

POST-DOCTORAL STUDENTS 1. 2. 3. 4. 5. 6. 7. 8. 9.

Wei-Tao Wu, PhD – CFD simulation of thrombosis. 5/2015 - 4/2016 Fang Yang, PhD – Micro fluidic visualization of blood flow in blood wetted devices; 11/2013 – 1/2016 Samuel J. Hund, PhD, Multi-scale modeling of thrombosis in artificial circulation. 1/2011-8/2012 Antonio Ferriera, PhD, U Pittsburgh – Identifying and Optimizing Ventricular Recovery of VAD Patients. 1/2009-10/2012 Stijn Vandenberghe, PhD, U. Ghent, Belgium – Optimization of hemodynamic control of rotary blood pumps. 3/2004-12/2007. Fangjun Shu, PhD, Flow Visualization of PediaFlow and Toddler VAD, 1/2005-12/2008 Chengung Diao, Ph.D., University of Maryland, 2004. Flow visualization of Pediatric VAD. 5/200412/2004. Naik Taikeswar, PhD, University of Minnesota, 2003: Theoretical and experimental evaluation of red blood cell micromechanics. 9/2003-7/2005. Greg W. Burgreen, PhD, [Old Dominion University 1994]: Computational flow optimization of rotary blood pump. 7/1994-7/1995.

ADDITIONAL STUDENTS ADVISED (Outcome) 10. 11. 12. 13. 14. 15. 16. 17.

18.

Soroush Khanlou, Development of modular circulatory simulator, Summer-2009 David Wang, PhD, S2004, [served as mentor for CMU’s Entrepreneurship Program.] Martin Tabaksblatt, BS (EE) 7/03-6/04, Multi-objective Feedback Control of Artificial Hearts, (Accepted to Medical School, Stony Brook; complete professional Master’s – without dissertation.) Sara Doll, BS, (ca 2000-2002) [served as undergraduate mentor, and advisor on research project, Characterization of Stereo Stethoscope.] Kirk Lehmann, MS, “A Starling-Responsive Mock Circulatory Loop for Ventricular Assist Hemodynamic Simulation.” [5/1995-7/1996] (Industrial Position – Cardiac Assist Technologies,) Devin Amin, BS (EE), MD/PhD (EE) Adaptive physiologic control algorithm for rotary blood pumps. [5/1996-4/1998]: (Medical School, University of Pittsburgh.) Ahmed Nadeem, MS (EE); PhD (BME) Multidisciplinary optimization of magnetic bearing. [1/19964/1997]: Kunihisa Kono, MS (ME), [Waseda University, Tokyo Japan]: Development of mathematical hemolysis model by choosing energy dissipation as its main cause and some analysis from the fluid dynamical point of view (advisor: M. Umezu, Waseda Univ.). 5/2/1999 (Returned to Waseda University.) Stijn Vandenberghe, BS(BME), U. Ghent, Belgium – Visiting student. Optimization of hemodynamic control of rotary blood pumps. 12/2002-5/2003. (Completed PhD at U Ghent, then returned for Post Doc at CMU 2004-2007. Subsequently got research faculty position at UoP Dept of Surgery.)

UNDERGRADUATE INTERNS ADVISED 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

Soroush Khanlou, Development of modular circulatory simulator, 2009 (SURG awardee.) Dave Hower, Investigation of novel vascular stent, 2005. Thomas Robey, Thermoelectric Control of Heat Transfer, 1998. Benjamin Ewing, Modified rotary blood pump to minimize thermal blood trauma, 1998. Kirk Lehman, Development of digital controller for mock circulatory blood pump, 1997. Lauren DeRosett, Investigation of blood trauma due to magnetic and electric fields, 1996. Devin Amin, Investigation of physiology of control for pulseless perfusion, 1995. Leslie Sgroi, Further development of ventricular casting methodology, 1994. Amy Thompson, Development of ventricular casting methodology, 1993. Rania Hanna, Hemodynamic analysis of in-vivo evaluation of implantable LVAD, 1992.

SENIOR DESIGN PROJECTS ADVISED 1. 2. 3.

Erica Authier, et al. Design of Automated Medication Delivery System, 2002. Damian Filer, et al. Design of Pulse Duplicating Pump Device, 1995. D. Quan, et al. Design of Energy Recovery System from Knee Flexion, 1994.

JF Antaki, pg 11 of 62

GRADUATE PROJECTS ADVISED 1.

Jay McCormack, Design Shape Grammar for Rotary Blood Pump (advisor: Prof. Jon Cagan) [CMU], 1998.

INTERNATIONAL STUDENTS SPONSORED 1. 2. 3. 4. 5.

Jeongho Kim, Korea, CFD optimization of pediatric blood pump. 1/1/08 – 12/30/08 NahnJu Kim, Seoul Nat Univ,: Effects of surface roughness upon hemolysis. 1/05 - 2/06 SungSik Lee, Seoul Nat Univ, Viscoelastic effects of blood trauma. 7/04- 1/05 Hirofumi Mukuo, Waseda University, Japan, 1995–1996. Kunisha Kono, Waseda University, Japan, 6/1997-8/1998.

THESIS COMMITTEE SERVICE – Carnegie Mellon Student name 1. Joshua Woolley

Deg. PhD

2. 3. 4. 5. 6.

PhD PhD PhD PhD MS

ICES

7. David Schmidt

PhD

CEE

8. Christine Scotti

PhD

BME

9. James Kubichek 10. Jane Valentine

PhD PhD

ME BME

Optimization of Thrombectomy Catheter Biomechanical Analysis of heart valve [CFD Simulation of Abdominal Aortic Anneurysm] [Mechanotransduction] [Biosensor Development]

11. Craig Lehocky

PhD

RI

[Brain Navigation]

Prahlad Menon Chia-Yuan Chen Sanna Gaspard Onur Dur Joshua Chung

Dept. BME (Pitt)

Title Immunological and hemostatic responses to ventricular assist device support

2014

Dates

Advisor WR Wagner

May, 2013 May 2012 May 2011 April 2011 4/24/09

Ender Finol

4/19/09

Michel Sacks

9/2007

Ender Finol

5/2007 June 2005 – July 2013 9/2013-pres

Phillip LeDuc Pryzbycien Riviere

THESIS COMMITTEE SERVICE – U Pittsburgh 1.

Carl Johnson [MD/PhD], (UoP) Development of assays for biocompatibility of pediatric blood pump, Jan 2007-Dec 2010. Advisor: William R. Wagner

2.

Nicholas Gialias [MS], [Towards the development of an artificial hand.] (Yoky Matsuoto), 9.13.04-(left program)

3.

Joie Marhefka [PhD], (UoP) [Drag reducing polymer effect on blood rheology.] Sept 2005-March 2007, Advisor, marina Kameneva.

4.

David G. Galati [PhD], Game Theoretic Target Assignment Strategies in Competitive Multi-Team Systems. (MA Simaan), 11.21.03 – 12.06.04

5.

Trevor Snyder [PhD], Preclinical Biocompatibility Assessment Of Cardiovascular Devices (WR Wagner), 7/2003-3/2006.

6.

Andrew Hunsberger [MS/BME], [Experimental and Theoretical Analysis of Hemodynamics of Patients receiving Pneumatic VAD]. 1/2003 – 10/2004

7.

Hiroatsu Sugimoto, [MS] Effects of leaflet stiffness on the dynamic motion of the aortic heart valve

JF Antaki, pg 12 of 62 (Michael Sacks), 4.20.2003 – 10/2003. 8.

Timothy Nolan, MS (BME), Development of a Dynamic Balloon Volume Sensor (advisor: William Federspiel), 2002 – 11/2003.

9.

Yong Liu, PhD (EE), Nash Based Strategies for Control of Extended Complex Systems (advisor: Marwan Simaan), 9/2002 – 10/2003

10.

Ivan Malcevic, PhD (CE) [Carnegie Mellon University], Simulation of Navier Stokes Flows with Dynamic Boundaries (principal advisor: Omar Ghattas), 5/2001.

11.

Tamara Tolou, PhD (BME), Development of Controller for Intravascular Blood Oxygenator (advisor: WJ Federspiel), 1999.

12.

Jason Bultman, MS (BME, Dept of Bioengineering), Development of Extracorporeal Blood Oxygenator (advisor: WJ Federspiel), 1999.

13.

Nancy Morse, PhD (EE) [UCSB], Analysis of Fundamental Limits of Magnetic Bearing Systems and Controller Design for a Conical Magnetic Bearing System (advisor: Brad Paden, PhD), 12/1999.

14.

George Biros, PhD (CE) [Carnegie Mellon University], Magnetohydrodynamic Optimization of Blood Flow (advisor: Omar Ghattas), 5/1999.

15.

Tim Corcoran, PhD (BME) [Carnegie Mellon], Flow visualization of nebulized drug delivery (advisor: Norman Chigier, PhD), 1998.

16.

James R. Kneller, MS (BME), Department of Cardiology, Presbyterian Hospital, Penetrating Through Atherosclerotic Plaque into Rabbit Arteries with Micro fabricated Probes (advisor: Marc Feldman, MD), 1997.

17.

Kengo Baba, MS (BME), Department of Cardiology, Children’s Hospital, Use of Backscatter Ultrasound Signals to Estimate Flow Rate and Volume Ratios, 1997.

18.

Rebecca Levine, MS (BME), Department of Orthopedics, 1996.

19.

Serena Chan, MS (BME), Department of Orthopedics, 1995.

OTHER ACADEMIC SERVICE ACTIVITIES 2013 2011-2013 2006-2010 2007 11-2006 2006 2005

CIT Manufacturing Committee Promotions and Tenure Committee, CIT

2004 - pres

CIT Faculty Awards Committee

2002-3

Ad Hoc Committee Promotion and Tenure, School of Health and Rehabilitation Science.

2002

AIMBE Academic Council - 10/22/2002.

Faculty Senate, Carnegie Mellon Heinz School – Federal Career Day, Panelist Member, PhD Prelim Exam ad hoc committee – Justin Newberg Chair, PhD Preliminary Exam ad hoc committee: Christine Scotti Member, PhD Prelim Exam ad hoc committee - Shann-Ching Chair, PhD Preliminary Exam ad hoc committee: Sanna Gaspard

Bioengineering Undergraduate Curriculum Retreat - participant. 1997

Facilitator: UPMC MD/PhD Enrichment Program. Review Board Member: CMU Study of Socio-economic impact of transplantation.

1996 - 1999

PhD Preliminary Exam Committee, Bioengineering. PhD Preliminary Exam Committee, Mechanical Engineering.

1992 - pres.

Department of Cardiothoracic Surgery, participated in surgical resident interviews.

JF Antaki, pg 13 of 62

1989 - 1991

Steering Committee for Middle States Accreditation, Graduate Student Representative, as appointed by the Chancellor of the University.

1989 - 1990

University Council on Graduate Study (advisory committee to Provost), Graduate Student Representative.

1988 - 1990

Graduate and Professional Student Association, Vice President.

1987 - 1988

Graduate and Professional Student Association, President.

1987

Educational Policy Committee, School of Engineering, Student Representative. Engineering Graduate Advisory Committee, Student Representative.

1985 - 1986

Engineering Graduate Student Board, Vice President.

1984 - 1985

Rensselaer Sports Car Association, Assistant Manager [RPI].

HONORS AND AWARDS 2009

Steven Fenves Award for Systems Research. ($1500)

2003, August

H. Koyanagi Young Investigator Award: 11th Congress of The International Society for Rotary Blood Pumps

2002, March

Inducted as Fellow of American Institute for Medical and Biological Engineering (AIMBE) “In recognition of outstanding contributions to the field of Medical and Biological Engineering.”

2002, Jan.

Keynote Lecture, NSF Design Contractors Meeting, San Juan, PR.

2001

Keynote Lecture, ASME International Design Engineering Technical Conference, Pittsburgh, PA.

2001, June

IEEE Control System Technology Award (shared with BE Paden, USCB) for development of “Streamliner” heart-assist pump.

1999, April

Voted by Pittsburgh Magazine as one of “40 under 40” leaders for Pittsburgh’s future.

1999

Teaching award: Recognized by undergraduate as “Faculty who have made a positive influence in my life.” One of 12 Faculty awarded in Engineering School.

1998

Proclamation by Mayor Tom Murphy of Pittsburgh, “Dr. Jim Antaki Day,” 10/15/1998.

1996

IEEE/EMBS Early Investigator Award - Finalist (1 out of 2 in country).

1995

ASAIO/Medforte Innovation Award for "A Gait Powered Autologous Battery Charging System for Artificial Organs."

1991

American Heart Association: Fellow.

1985

RPI Alumni Scholar; New York State Regents Scholar; GM Scholar finalist.

1985

“Most Innovative Propulsion System,” Anything-That-Floats Boat Contest, Rensselaer Polytechnic Institute. (JF Antaki and Timothy Murphy).

1981

National Honor Society - Letter of Commendation.

GRANTS ACTIVE (most recent on top) [NIH Format] Project Number (Principal Investigator) Source Title of Project (or Subproject) The major goals of this project are… History

Dates of Approved/Proposed Project Annual Direct Costs

Person Months (Cal/Academic/Summer) Role

JF Antaki, pg 14 of 62

02/1/15 – 01/30/18 $3,613,799 (total) Y1-4: 33% effort (3 calendar) National Institute of Health/NHLBI $2,342,478 (direct) (CMU $ ) CORA: Cardiac Outcomes Risk Assessment: Cardiac Counselor for End Stage Heart Failure Performance Sites: Carnegie Mellon University; West Penn Allegheny Health Network; Duke University; Harvard University Medical Center; U Colorado, Denver. Development and clinical validation of decision support software to facilitate treatment of end-stage heart failure, including palliative care and VAD therapy. R01 (Antaki)

(Antaki) 6/30/2014 – 5/31/2015 0.0 effort Disruptive Health Technology $112,000 Institute (Highmark) Pre-Clinical Readiness Testing of Breast Palpation Aid for Home and Primary Care The major goals of this project are to develop a novel inexpensive device to visualize breast lesions. (Antaki) 9/1/2014 – 8/31/2016 0.0 effort CMU-CIT IIE Program $11,150 Innovation in Engineering Education Program: Incorporating Improvisational Acting & Inventive Problem-Solving in Engineering The major goals of this project are to enhance an existing course that I had developed, “Inventive Problem Solving in Biomedical Engineering’” R21EB017807-01(Trumble) 9/1/2013 – 8/31/2015 0.45 calendar x 2y NIH/NIBIB $401,709 Computational and In Vivo Analysis of Applied Apical Torsion for Cardiac Support The major goals of this project are to explore the possibility of using applied apical torsion as a means to assist the failing heart without contacting the blood. 1R01HL117637-01 (Federspiel) National Institute of Health/NHLBI

1/1/13 – 12/30/15 $ 3,445,439 CMU: $ $258,582 (4 yr only) $168,348 (direct)

Y1-4: 1.0 calendar Y0: 0.0 calendar Consortium PI

Paracorporeal Ambulatory Assist Lung The major goals of this project are Development of a integrated pump-oxygenator for adults with pulmonary dysfunction: SA 1. To optimize the design and operational parameters of the PAAL; SA2: To build PAAL prototypes; SA3: To further improve hemocompatibility of the PAAL; SA4: To perform acute and chronic animal studies. History: Awarded PI: Pantalos (U Louisville) Source: NASA

10/1/2012 – 10/30/2012 $0 (grant provides opportunity to fly aboard microgravity aircraft)

0.0 calendar Co-I

The major goals of this project are to perform microgravity experiments aboard… History: submitted 16. December 2011, Awarded date. 2T32EB003392 (Woo) 9/1/2011 – 8/30/2016 0.0 calendar NIH/NHLBI $449,225 (sub) Consortium PI Training in Biomechanics in Regenerative Medicine (BiRM) The major goals of this project are to provide fellowship opportunities for PhD students pursuing careers in regenerative medicine with special emphasis on biomechanics. History: Awarded 11/27/10: Scored 24 – with Dr. M. Sacks as PI. Changed to S. Woo.

JF Antaki, pg 15 of 62

Source: National Institute of Health/NHLBI (primary) Program: R01 (BRG) Identifier: 1 R01 HL089456-A2 Title: Multiscale Model of Thrombosis in Artificial Circulation. Duration: 2/1/09 - 1/31/14 Total Direct: $1,811,749 Total Costs: $2,604,896 PI: Antaki Role: PI: 16.7% Status: Priority score 134, (2.8%ile) This project aims to develop a mathematical computer simulation to predict the progression of shear-mediated thrombosis. GRANTS PENDING (reverse chronological order – most recent first)

R01 (Benza) 04/1/16 – 03/30/21 Y1-5: 12% effort (1.5 calendar) National Institute of Health/NHLBI $2,757,220 (CMU $ $1,598,107) PHORA: Pulmonary Hypertension Outcomes Risk Assessment Performance Sites: West Penn Allegheny Health Network; Carnegie Mellon University; BlenderHouse, LLC Development of decision support software to facilitate treatment of pulmonary hypertension. NIHT32 (Woo) 9/1/2016 – 8/30/2021 0.0 calendar NIH/NHLBI $449,225 (sub) Consortium PI Training in Biomechanics in Regenerative Medicine (BiRM) - renewal The major goals of this project are to provide fellowship opportunities for PhD students pursuing careers in regenerative medicine with special emphasis on biomechanics. Note all support is for students. Status: submitted 7-5-15, pending review STTR Phase 1 (R41) (Antaki) 04/1/15 – 03/30/16 National Institute of Health/NCI $ 173,661 (CMU $105,211) Palpation Aid for Screening Breast Lesions in Home and Primary Care Performance Site: Carnegie Mellon University; Daedalus Develop low cost device to visualize lesions of the breast. Status: submitted 7-5-14, unscored; will resubmit Dec 2015

Role: P.I. Y1: 10% effort (1.2 calendar)

2R42HL120428-02 (Antaki) 04/1/14 – 03/30/16 Y1: 10% effort (1.2 calendar) National Institute of Health/NHLBI $1,351,372 (CMU $401,597) CHRiSS: Cardiac Health Risk Stratification System Performance Site: Carnegie Mellon University; BlenderHouse, LLC Development of decision support software to facilitate treatment of end-stage heart failure, to optimize the use of VAD therapy, and reduce incidence of readmission. R21HL113770-01 (Trumble) 9/1/2012 – 8/31/2014 0.45 calendar x 2y NIH/NHLBI $405,218 Apical torsion as a means to assist the failing heart. The major goals of this project are to develop a device that attaches to the apex of the heart for acute circulatory assistance. R01HL113467-01A1 (Trumble) 7/1/2013 – 6/30/2018 NIH/NHLBI $1,890,892 Development and Testing of a Muscle-Powered Cardiac Assist Device

1.17 calendar x 5y

JF Antaki, pg 16 of 62

GRANTS COMPLETED (reverse chronological order, most recent on top) 1R41HL120428 (Antaki) 07/1/13 – 06/30/14 Y1: 10% effort (1.2 calendar) National Institute of Health/NHLBI $ 150,000 CHRiSS: Cardiac Health Risk Stratification System Performance Site: Carnegie Mellon University; BlenderHouse, LLC; Allegheny General Hospital Development of decision support software to facilitate treatment of end-stage heart failure, to optimize the use of VAD therapy, and reduce incidence of readmission. 1R43HL110508-01A1 (SBIR Phase-1) (Gandini/Antaki) National Institute of Health/NHLBI

7/1/12 – 9/30/13

Y1: 1.0 calendar Y2: 0.5 calendar

$ 434,843 Consortium PI CMU: $ 73,067 mPharesis: Blood Filtration System for Treatment of Severe Malaria The major goals of this project are Development of dialysis-like device for clearing infected blood from patient with severe malaria – based on magnetic properties of infected blood. History: submitted 12-05-2010, scored 56; resubmitted Dec 5, 2011, scored 24 Source: National Institute of Health Division: NHLBI Identifier: 1R01 HL086918-01A1 Title: Identification and Optimization of Ventricular Recovery of VAD Patients Duration: 7/1/2007-6/30/2012, NCE to 6/30/2014 Total Costs: $3,144,363 CMU Subcontract: $513,093 + 232,506 PI: J Gorcsan, MD Role: Consortium PI Support: 10% Status: scored 121 (1.1 %ile), awarded Performance Site: University of Pittsburgh; Carnegie Mellon Study of cardiac recovery in patients receiving LVADs. Entails computer simulation, in-vitro and in-vivo experimentation. Specific aims include: Specific Aim # 1: Non-Invasive Determination of LV Function. Specific Aim # 2: Accurate Control of Myocardial Load. Specific Aim # 3: Maximize LV Functional Recovery. IIP1035061 (Antaki) 9/1/10 – 8/30/13 1.2 calendar NSF I/UCRC $177,020 National Center for e-Design: Annexation of Carnegie Mellon University The major goals of this project are to establish of a Research Site at CMU as part of the National Center for eDesign. The ultimate objective is development network and software tools to enable e-Design of medical devices, and collaboration between clinical professionals, industry and university. Source: temporarily suspended due to lack of Industry partners. Source: National Institute of Health Program: Pumps for Kids Infants and Neonates (PumpKIN) Contract: HHSN268201000015C Contract No. N01HV00235 Title: PediaFlow Pediatric VAD Duration: 1/1/2010–12/30/2014 Total Costs: $5,900,000+/CMU Subcontract: $732,882 $471,761 (Direct) PI: HS Borovetz, PhD Role: Consortium P.I.; Project Director (Y1&2: 17% 2mo; Y3&4: 1mo) Status: Awarded 1/10/10

JF Antaki, pg 17 of 62 University of Pittsburgh, CMU, Children’s Hospital of Pittsburgh, LaunchPoint, LLC, WorldHeart, Inc. Renewal/Continuation of previous contract: Collaboration between UoP Bioengineering Department, Children’s Hospital of Pittsburgh, Magnetic Moments (Santa Barbara), and MedQuest Industries (Salt Lake City) to develop miniature cardiac support system for chronic care of young patients (from infancy to appx 2 yrs old.) Performance Sites:

Source: National Institute of Health/NIGMS Program: Kirschstein NRSA Individual Fellowship Award: 1F31GM089135-01A1 Title: Project Title: Computational and In-Vitro Modeling of a Surgical Hemostasis Device Duration: 1/1/10 - 12/30/12 Total Direct: Total Costs: Student: Matthew Oberdier Sponsor: Antaki Role: Sponsor: 0% (support entirely for student) Status: awarded This project aims to evaluate the hemodynamic and physiologic response of elevated intracranial pressure. Source: National Institute of Health/NHLBI (primary) Program: ARRA – Administrative Supplement Award: 3R01JL089456 Title: Multiscale Model of Thrombosis in Artificial Circulation. Duration: 7/1/09 - 6/30/11 Total Direct: $236,986 Total Costs: $368,158 PI: Antaki Role: PI: 0% (supplement is entirely for addition of a new FTE) Status: awarded The goal of this supplement is to study the microhemodynamics associated with malaria-infected blood flow. Source: National Science Foundation Program: Control, Networks, and Computational Intelligence (ECS-0300097) Title: Patient Adaptive Feedback Control of Rotary Heart Duration: 5/1/2007-4/30/2010 Total Costs: $270,000 CMU Subcontract: $37,707 PI: M. A. Simaan (UoP) Role: PI of subcontract Support: 8.6% (0.5 months/yr x 3yr) Status: awarded Performance Site: University of Pittsburgh; Carnegie Mellon Theoretical study to develop algorithms for combining multiple sources of patient data to drive artificial heart. Source: Program: Title: Project Period: P.I. Role: Total Direct: CMU Subcontract Effort: Performance Site:

National Institute of Health NIBIB National Research Service Award Institutional Research Training Grants (T32) Training in Biomechanics in Regenerative Medicine (BRM) 4/1/04-3/31/09 Michael Sacks, PhD Consortium P.I. $2,188,313 $485,258 5% University of Pittsburgh

JF Antaki, pg 18 of 62

Source: Program: Title: Project Period: P.I. Role: Total Direct: CMU Subcontract Effort: Performance Site:

National Institute of Health T32 GM08208-15 NIBIB National Research Service Award Institutional Research Training Grants (T32) Medical Scientist Training Program 7/1/02-6/30/07 Sanjeev Shroff Faculty $unknown $0 5% University of Pittsburgh

Source: Carnegie Mellon University Program: GAP – Phase 1 Title: A Blood Purification Device for the Treatment of Malaria Duration: 5/1/09 - 6/30/09 (2 months) Total Direct: $25,782 Total CMU: $12,063 PI: Gandini Role: Consortiuim PI: 5% Status: Awarded This project aims to perform proof of principle experiments on a device to purify malaria by magnetic cell separation. Source: National Institute of Health/NIBIB (primary) Program: R21 Identifier: 1R21EB007651-01A2 Title: Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics Duration: 7/1/07 - 6/31/09 Total Direct: $275,000 Total Costs: $350,804 Role: Co-I, 5% effort Applicant Org: CMU The aim of this project is to validate in vitro numerical models of fluid-structure interaction of abdominal aortic aneurysms and apply the FSI technique to predict the in vivo AAA biomechanics by means of patient-specific blood flow velocity obtained from PC-MRI.

Source: National Institute of Health/NHLBI (primary) Program: SBIR Phase I Title: MEMS Pressure Sensor for a Pediatric VAD Duration: 2/1/07 - 1/31/08 Total Direct: $132,180 Total Costs: $223,082 P.I: Paden Role: Consultant – 10 hours budgeted Status: active (scored 193) Applicant Org: LaunchPoint Technologies, Inc. This project aims to enable end-diastolic pressure control for the PediaFlowTM by developing a miniature pressure sensor to be embedded in the pump inflow wall. Source: Program: Contract: Title:

National Institute of Health BAA NHLBI-HV-04-01 HHSN268200448192C Pediatric Cardiac Support.

JF Antaki, pg 19 of 62

Duration: Total Costs: CMU Subcontract: PI: Role: Status: Performance Sites:

3/30/2004–3/29/2009 $4,490,691 $4,024,419 (Direct) $663,765 $474,935 (Direct) HS Borovetz, PhD P.I. Subcontract; Project Director (67% x 5 yrs) Active University of Pittsburgh, CMU, Children’s Hospital of Pittsburgh, LaunchPoint, LLC, MedQuest Collaboration between UoP Bioengineering Department, Children’s Hospital of Pittsburgh, Magnetic Moments (Santa Barbara), and MedQuest Industries (Salt Lake City) to develop miniature cardiac support system for chronic care of young patients (from infancy to appx 2 yrs old.) Source: National Institute of Health Division: CHHD (Child Health and Human Develoment) Program: MGRS (Minority Graduate Research Supplement Title: Development of Stage 1 Pressure Ulcer Diagnostic Tool Student: Gaspard Role: Advisor/Mentor Effort: 0% Parent Grant: HHSN268200448192C, Pediatric Cardiac Support. PI: Brienza Duration: 6/1/2007-5/30/2008 Total Costs: $62,319 Performance Sites: University of Pittsburgh; Carnegie Mellon Source: Program: Title:

National Science Foundation Industry/University Collaborative Research Center (I/UCRC) Planning Grant: Annexation of Carnegie Mellon as a Research Site “Center for Medical Device Innovation and Optimization” Planning Grant - 3.31.05 Duration: 1/1/06 – 6/30/07 (up to 18 months) – extended to 1230/07() Total Direct: $6,897 Total Costs: $10,000 Role: PI (0%) Status: Active Performance Site: CMU This is a planning award to prepare a full proposal to establish a Research Site at CMU as part of the National Center for e-Design. The ultimate objective is development network and software tools to enable e-Design of medical devices, and collaboration between clinical professionals, industry and university.

Source: National Institute of Health Division: NHLBI Program: MGRS (Minority Graduate Research Supplement Student: Dorian Arnold Role: Advisor/Mentor Effort: 0% Parent Grant: HHSN268200448192C, Pediatric Cardiac Support. PI: Shroff Duration: 7/1/2005-11/30/2010 Total Costs: $127,972 Performance Sites: University of Pittsburgh; Carnegie Mellon Source: Division: Program:

National Institute of Health NHLBI MGRS (Minority Graduate Research Supplement

JF Antaki, pg 20 of 62

Student: Arielle Drummond Role: Advisor/Mentor Effort: 0% Parent Grant: Cardiovascular Bioengineering Training Program [UoP] PI: Shroff Duration: 9/1/2005-8/30/2007 Total Costs: $40,000 Performance Sites: University of Pittsburgh; Carnegie Mellon Source: Program: Student: Role: Duration: Total: status:

National Institute of Health F31 – Kirschstein NRSA Individual (Minority) Fellowship Application Arielle Drummond Mentor/Advisor 9/1/2008-8/30/2011 $32,408 awarded

Source: National Institute of Health/NHLBI Program: STTR Phase I, Heart Lung Institute (1R41HL082251-01) Title: The Quintessential Ventricular Cannula Duration: 7/1/05 – 6/30/06 – extended to 6/30/07 Total Direct: $171,151 Total Costs: $ 237,161 Subcontract: $96,129 $111,451 Role: PI Commitment: 15% (1.8 person-months) Status: Active – Priority score 177 Awarded to: LaunchPoint, Inc.; subcontract to CMU Development of cannula suitable for use adult ventricular assist device. Collaboration between LaunchPoint, CMU, and UoP Source: Program: Title: Project Period: P.I.: Role: Total Direct: CMU Subcontract Effort:

National Institute of Health NHLBI National Research Service Award Institutional Research Training Grants (T32) Cardiovascular Bioengineering Training Program 05/01/2004 – 04/30/2009 Sanjeev G. Shroff, PhD Training Faculty $2,061,058 $0 (all funds support Pitt students) 5%

Source: National Science Foundation Program: ECS-BE: Non-Announcement Research Title: Periodicity and Power Minimization in Maglev Artificial Hearts Duration: 4/01/04 - 3/31/07 Total Costs: $210,000 CMU Subcontract: $61,666 total PI: BE Paden Role: Co-Investigator Support: Year 1: 0% Year 2: 8.3% + 1 graduate student: Year 3: 0% Status: Active Performance Site: UCSB, CMU Theoretical study to develop algorithms for reducing power consumption of maglev blood pumps. Collaboration with Professors Brad Paden, Alberto Isidori, and Lorenzo Marconi in the supervision of the PhD to

JF Antaki, pg 21 of 62

study algorithms for minimizing power consumption through application of principles of repetitive control. Source: National Institute of Health/NHLBI Program: NHLBI STTR Phase I (1-R43-HL077028-01) Title: Development of a Ventricular Assist System for Toddlers & Small Children Duration: 7/15/2004-6/14/2005 (extended to 6/14/2006) Total budget: $200,000 CMU Subcontract: $112,142 Role: PI Commitment 25% (3 person-months) Performance Site: Carnegie Mellon University and LaunchPoint, LLC Collaboration between CMU, LaunchPoint, LLC, and UoP to develop small blood pump for temporary cardiac support of small children. Source: National Institute of Health Program: ECS-BE: Non-Announcement Research Title: Interagency Registry of Mechanical Circulatory Support for End Stage Heart Failure Duration: 1/01/05 - 12/31/11 [Terminated prematurely] Total Costs: $6,338,904 CMU Subcontract: $362,134 ($263,545 direct) PI: James Kirklin, MD (UAB) Role: P.I. Subcontract Commitment: Y1: 17% (2 person-months) Y2: 0 Y3-5: 0% [Was 8% (1 person-months)] Status: Terminated prematurely at Y3 Performance Site: UAB, UPMC, Columbia, CMU Development of interagency Registry of Mechanical Circulatory Support for End Stage Heart Failure. Source: National Science Foundation Program: Control, Networks, and Computational Intelligence (ECS-0300097) Title: Patient Adaptive Controllers for Heart Assist Devices Duration: 5/1/2003-4/30/2006 Total Costs: $360,000 CMU Subcontract: $0 (all funds support Pitt students) PI: M. A. Simaan Role: Co-Investigator Commitment: 4.2% (0.5 person-months) Status: Active Performance Site: University of Pittsburgh Theoretical study to develop algorithms for combining multiple Sources of patient data to drive artificial heart. Source: Program:

National Institute of Health/NHLBI SBIR Phase II, Heart Lung Institute (2R44HL066656-02A2 > 5R44HL066656-03) Title: Physiological Controller for Rotary Blood Pumps Duration: 11/15/2003-10/14/2005 extended to 4/14/2006 Total Direct: $568,038 Total Costs: $749,937 CMU Subcontract: $0 Role: Consultant, 20% (Originally PI, 40%) Status: completed. Performance Site: LaunchPoint, LLC (Originally AntakaMatics, Inc.) Collaboration between LaunchPoint, LLC, and MedQuest Industries (Salt Lake City) to develop intelligent controller for permanent, implanted heart-assist pump.

JF Antaki, pg 22 of 62

Source: National Science Foundation Program: I/UCRC Title: NSF Center for e-Design and Realization of Engineered Products and Systems. Duration: 7/1/2003–8/31/2008 Total Direct: $250,000 JFA Budget Support for 1 Pitt student x 2 yrs (appx.) PI: Bartholomew Nnaji, PhD (Industrial Engineering, UoP) Role: Co-I Effort/Support: 5% Status: completed Performance Sites: UoP, UMass at Amherst, and Carnegie Mellon University. Establishment of a multi-university Industry/University Cooperative Research Center for e-Design: IT Enabled Design and Realization of Engineered Products and Systems at the University of Pittsburgh, the University of Massachusetts at Amherst, and Carnegie Mellon University. Source: National Science Foundation Program: ITR/ACS (ACI-0086093) Title: Simulation of Flows with Dynamic Interfaces on Multi-Teraflop Computers Duration: 9/1/2000–8/31/2004 (extended to 8/31/2005) Total Direct: $2,333,053 Pro-rata: $611,048 (Total Costs: $3,113,304) PI: Omar Ghattas, PhD (CMU) Role: Sub-PI (University of Pittsburgh) Effort/Support: 16.7% Status: Active Performance Site: CMU, University of Pittsburgh Computational and experimental study of cellular flow, aimed at modeling the interaction of red blood cells with one another and with the walls of blood vessels and artificial devices. [Note: approximately 6 awards out of approximately 3000 letters of intent were funded from this program.] Source: National Institute of Health/NHLBI Program: SBIR-Phase-II (2R44HL61069-02A1) Title: Fuel cell power packs for left ventricular assist devices (ICET, Inc.) Duration: 10/1/2001–3/31/2003 (Extended to 12/2005) Total Direct: $750,000 to ICET Subcontract: Year 1: $20,777; Year 2: $46,811 PI: Sarang Sarangapani (ICET, Inc.) Role: Sub-PI Effort/Support: 8.3% Status: Active Performance Site: ICET, Inc.; University of Pittsburgh Subcontract to ICET, Inc. to develop a reliable power system that could support LVAD devices for longer hours without any interruption. University of Pittsburgh component is to investigate power requirements of patients on LVAD, and to evaluate quality of life concerns. Source: Commonwealth of Pennsylvania Title: Development of Artificial Organs and Related Products Duration: 7/1/2002-6/30/2003 Total Costs: $1,000,000 Pro Rata: $65,000 PI: Alan Russell Role: Co-Investigator (20%) Status: Active Performance Site: University of Pittsburgh Development of computer expert system for facilitating rehabilitation of patients receiving ventricular assist therapy.

JF Antaki, pg 23 of 62

Source: University of Pittsburgh Program: Innovation in Education Award Title: A Course in Integrated Bioengineering Design Duration: 5/2002-4/2003 Total Direct: $20,610 Pro-rata: $20,610 PI: JF Antaki Role: Course instructor Effort/Support: 0% (no salary support) Status: Active Performance Site: University of Pittsburgh Project aims to develop innovative curriculum for practical training of undergraduate students in Bioengineering. It involves mentors from industry who work directly with the students to teach practical skills of medical device design. Source: Program: Title: Duration: Total Costs: PI: Role: Effort/Support:

National Institute of Health/NHLBI NIH/NHLBI/1RO1HL65740-01 Development of a Chronic Artificial Lung 7/1/2000-6/30/2005 $3,689,307 Bartley P. Griffith, MD Co-Investigator Year 1 40.4%, Year 2: 30% (Year 3-4: consultant role @ 12,000/yr) Status: Active for two years; PI relocated to University of Maryland, Baltimore Subsequently frozen, pending secondary review. Performance Sites: Years 1-2: University of Pittsburgh Years 2-3: University of Maryland, Ension, Inc., AntakaMatics, Inc. Project aims to develop a compact wearable long-term-use pump-oxygenator for patients suffering from chronic respiratory disease. Antaki role will be to supervise development of feedback control system. Source: National Institute of Health/ National Heart Lung and Blood Institute Program: NIH SBIR Phase I (2R44HL066656-02A2) Title: Design Software for Cardiovascular Devices Duration: 8/15/2001B8/14/2002 Total budget: 96,236 Direct costs: 85,925 Performance Site: AntakaMatics, Inc. Development of software for computational fluid dynamics optimization of blood-wetted devices. Source: Commonwealth of Pennsylvania Title: Development of Artificial Organs and Related Products Duration: 7/1/2002-6/30/2002 Total Costs: $1,000,000 PI: Bartley P. Griffith, MD Role: Co-Investigator (33%) Performance Site: University of Pittsburgh Development of artificial muscle for use as an implantable prosthetic diaphragm. NIH SBIR Phase I, Heart Lung Institute (1R43HL66656-01) Title: Physiological Controller for Rotary Blood Pumps Duration: 7/15/2001-6/14/2002 Total budget: $97,827 Direct costs: $87,345 Role: PI (50%) Performance Site: AntakaMatics, Inc.; University of Pittsburgh Initial feasibility demonstration of flow estimator and control system to be used for implantable ventricular assist device.

JF Antaki, pg 24 of 62

Source: National Science Foundation Title: Patient-Adaptive Controllers and Control Strategies for Artificial Hearts (BES-981012) Duration: 1/1/1999-6/30/2001 Total Costs: $226,073 PI: JR Boston Role: Co-investigator (17%) Performance Site: University of Pittsburgh Theoretical study of multi-objective control for artificial hearts. Collaboration with Department of Electrical Engineering, University of Pittsburgh. Source: Commonwealth of Pennsylvania Title: Development of Artificial Organs Duration: 7/1/2000B6/30/2001 Total Costs: $1,000,000 PI: BP Griffith Role: Co-Investigator (33%) Performance Site: University of Pittsburgh Development of feedback-control algorithms for artificial organs. Source: National Institute of Health Program: N01-HV-58155 Title: Development of an Innovative Ventricular Assist System Duration: 10/1/1995-9/30/2000 Total Costs: $4,091,336 ($2,661,452 University of Pittsburgh) PI: KC Butler (Nimbus, Inc.) Role: Co-investigator (20%) Performance Site: University of Pittsburgh Develop a fully implantable, closed-loop controlled, axial flow blood pump system suitable for chronic support of patients in refractory univentricular and/or biventricular failure. Whitaker Foundation: Graduate Fellowship. Erik Sorensen, PI, Total direct: $96,000, Duration: 9/1/1997-8/31/2000 Role: Faculty Advisor Performance Site: University of Pittsburgh Development of theoretical model of platelet mediated thrombosis. NIH: Development of an Innovative Ventricular Assist System. KC Butler (Nimbus, Inc.) PI, $4,091,336 total ($2,661,452 University of Pittsburgh), co-investigator (50, 50, 50, 25, 20%), 7/1/1995-6/30/2000. WM Keck Foundation: The WM Keck Bioengineering Design and Manufacturing Laboratory. Bopaya Bidanda, Industrial Engineering, PI, $950,000, 7/1/1997-6/30/1999. NASA/Langley Research Center: Space Act Agreement: Development of Magnetic Bearing for Rotary Blood Pump. 4/24/1997-4/24/1999. NIH SBIR Phase 2: Axial Flow Blood Pump with Simplified Bearings. Ken Butler (Nimbus, Inc.), PI, $750,000 total ($361,113 total University of Pittsburgh direct), co-investigator (8% effort), 3/1/1996-2/28/1998. McGowan Charitable Fund: Continued Development of Streamliner Artificial Heart. JF Antaki and BP Griffith, coPI, $450,000, 7/1/1997-6/30/1998. Japanese Government: Engineering Analysis of Flow Behavior of Blood-Biomaterial Interfaces Duration. M Umezu, $4,000 travel award, ca. 12/1997.

JF Antaki, pg 25 of 62

Contract: Cardiac Assist Technologies: Flow Visualization Study of Centrifugal Rotary Blood Pump. $17,600, 10/1997. Contract: Cardiac Assist Technologies: Hemodynamic Characterization of Centrifugal Rotary Blood Pump. $3,056, 10/1997. McGowan Foundation: Development of the Pitt Streamliner Ventricular Assist System. BP Griffith, JF Antaki, coPI, $500,000 total, 7/1/1995-6/30/1997. NASA/Langley Research Center: Space Act Agreement: Development of Magnetic Bearing for Rotary Blood Pump. 4/24/1995-4/24/1997. The McCune Foundation: Cardiopulmonary Organ Development. Bartley P Griffith, MD, PI, James F Antaki, PhD, Co-investigator, $250,000. 10/1/1996-9/30/1997. Whitaker Foundation, Biomedical Engineering Development Award: Clinical Cardiovascular Bioengineering. HS Borovetz, PI, $748,954, collaborating investigator (8%), 1/1/1995-12/31/1997. Ben Franklin Technology Center of Western Pennsylvania: Development of a Novel Blood Rheometer. R Ghude, PI, $80,000, ($7,000 University of Pittsburgh direct), 6% effort, 1995. NIH SBIR Phase 1: Development of a Gait-Powered Battery Charging System for Artificial Organs. Tom Rintoul (Nimbus, Inc.), PI, $100,000 total ($31,700 University of Pittsburgh direct, JF Antaki, PI for the subcontract), (8% effort), 8/1/1996-1/30/1997. Argonaut Medical, Inc., value redemption of technology transfer to Nimbus Innovative Ventricular Assist Device (responsible for 50% share of $400,000), 1/1/1997. NIH SBIR Phase 1: Axial Flow Blood Pump with Simplified Bearings. Ken Butler (Nimbus, Inc.), PI, $100,000 total ($25,000 University of Pittsburgh), co-investigator (5%), 1/1/1994-4/30/1995. NIH SBIR, phase-I: Coronary Bypass Vessel Conditioning Device. KC Butler, PI, $49,998 ($15,645, University of Pittsburgh), 3/1/1993–8/1/1993. NIH, RO1: Investigation of an Implantable Axial Flow Blood Pump. HS Borovetz, PI, $1,579,746 ($890,395, University of Pittsburgh), 20% effort (co-investigator), 12/1/1992-11/1/1995. Veterans Administration: Intra-operative Right Ventricular Response to Left Ventricular Assist. RL Kormos, PI, $223,500, collaborating investigator (5%), 4/1992-3/1995. WL Gore, Inc. Awarded PTFE vascular graft material for in-vivo experiments. JF Antaki, approximately $3,000, 1/1992-12/1993. NIH SBIR, phase-II: Tandem Axial Flow Blood Pumps for Bi-ventricular Assist. BP Griffith, PI, $499,929 ($237,788, University of Pittsburgh), direct costs $309,593, 20% effort, 8/1/1992–7/31/1994. Veteran's Administration Merit Review: Interoperative Right Ventricular Response to Left Ventricular Assist. RL Kormos MD, PI, $223,500 direct costs, 5% effort, 7/1/1992–6/30/1994. American Heart Association: Investigation of the Passive Biomechanical Properties of the Heart. Post Doctoral Fellowship, P.I. $22,000, 7/1991–6/1992. PROFESSIONAL SOCIETY ACTIVITY 2014 2013

Medical & Biological Engineering and Computing– reviewer Cardiovascular Engineering and Technology – reviewer Circulation – reviewer Expert Reviews Hematology – reviewer Intermational Journal of Artificial Organs – reviewer Med Eng Physics – reviewer

JF Antaki, pg 26 of 62 BMMB – reviewer Natl Med Res Counsel (Singapore) – reviewer Binational Science Foundation (Israel) – reviwer Int J Chem E - reviewer 2010-13 Annals Biomedical Engineering – reviewer 2009 BMES Fall Annual Conference – co-Chair, Technical Program 7/2008 International Society of Rotary Blood Pumps - reviewer 12/2008 ASME J Med Devices - reviewer 5-8/2007 IEEE/EMBS, Associate Editor, Cardiovascular and Respiratory Systems Engineering 1/2007 NIH/NHLBI Special Emphasis Panel, BRG Program. 10/2006 NIH/NHLBI Special Emphasis Panel, BRP Program. 4/2006-pres Journal of Thoracic and Cardiovascular Surgery, Reviewer 4/2006 NIH/NHLBI Special Emphasis Panel, BRP Program. 2006* Session co-chair, BMES/IDEA workshop 7/2005 NIH/NHLBI Study Section reviewer, BRP Program 6/2005 NIH/NHLBI Study Section reviewer, SBIR Program 4/2005-pres Board Member: American Society of Artificial Internal Organs. 5/2006-pres Membership Committee Society of Artificial Internal Organs. 2/2005-pres Technology Expert Reviewer, Pittsburgh Life Sciences Greenhouse 12/2003-5/2005 First International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, International Program Committee Member 9/2003-pres Program Planning Committee: American Society of Artificial Internal Organs. 2003 International Advisory Committee: Second International Conference on Cardiovascular Medicine and Science. International Advisory Committee: First International Conference on Medical Implants. 2002* BMES Fall Annual Conference – session chair, [Computational Methods for Artificial Organ Design]* 2002 Department of Defense: Peer Review Medical Research Program – Study Section. 2001 National Institute of Health - Reviewer, SBIR Program 2000 National Institute of Health - Study Section Reviewer, BRP Program 1999 National Institute of Health - Study Section Reviewer, SBIR Program 1997 ASAIO Focus Group 1996 - pres Artificial Organs - Reviewer 1995 - 1998 ASAIO Program Planning Committee 1994 - pres ASAIO Journal - Reviewer 1991 - 1992 ASME Journal Biomechanical Engineering – Reviewer * - not completely certain of date and/or title

JF Antaki, pg 27 of 62

PROFESSIONAL LISTINGS $ $ $ $ $ $ $ $ $ $ $ $

Academic Keys Who's Who in Engineering Education (WWEE) (2004-pres.) Society for the Preservation and Advancement of the Harmonica (2000 – pres.) American Institute for Medical and Biological Engineering (AIMBE), Fellow (3/2002 - present) American Academy of Mechanics (1995 - present) International Society for Rotary Blood Pumps (1994 - present) Cardiovascular System Dynamics Society (1994 - present) International Society for Clinical Haemorheology (1994 - present) American Society for Artificial Internal Organs (1991 - present) American Society of Mechanical Engineers (1985 - present) Institute of Electrical and Electronics Engineers (1986 - present) National Society of Professional Engineers (1985 - 1993) Association for the Advancement for Medical Instrumentation (1986 - 1993)

NON-PROFESSIONAL AFFILIATIONS National Audubon Society (1987 - 2000), Sierra Club (1987 - 2000), Nature Conservancy (1988 - 2000), Cousteau Society (1988 - 1993), Foundation for Christian Living (1986 - 1996), Society for the Preservation and Advancement of the Harmonica (2001 - present). "AVOCATIONS" Antique radio collecting (since age 11). Auto repair and restoration (since age 12). Ragtime guitar and folk blues, bluegrass banjo, blues/gospel harmonica, gospel choir. (since birth of first child: playing with tinker toys, Play doh, and coloring.) FOREIGN LANGUAGES Relatively conversant en Francais (quel fromage!), with some knowledge of Arabic, Italian, German, and Japanese. Once "fluent" in Latin. COMPUTER SKILLS Programming in Fortran, BASIC, and ASYST. Introductory Matlab; FEMLAB. CAD: proficient with SolidWorks and competent in I-DEAS. Expert with EXCEL, MS Project. BOOK CHAPTERS 1.

Antaki, JF, R Wampler, The Future of Mechanical Circulatory Support. In. Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease (RL Kormos & L Miller, eds.), 2012, pp333-335.

2.

Drummond, A and JF Antaki, Virtual fit study of pediatric heart assist system, in Digital Humans, Cai, Y. (ed.) Springer-Verlag, Berlin Heidelberg, 2008.

3.

Kameneva MV and JF Antaki. Mechanical trauma to blood. In: OK Baskurt, MR Hardeman, MW Rampling and HJ Meiselman (Eds), Handbook of Hemorheology and Hemodynamics. IOS Press, Amsterdam, 2007, 206227.

4.

Antaki, JF, V Poirier, and FD Pagani. Engineering concepts in the design of mechanical circulatory support. ISHLT Monograph Series Mechanical Circulatory Support, Frazier, OH and Kirklin JK (eds.) Elsevier, Philadelphia, 2006

5.

Wu, ZJ, JF Antaki, K Litwak, MV Kameneva, HS Borovetz, RL Kormos. Ventricular assist devices: current status and future perspectives. In New Frontiers in Biomedical Engineering. Huang (ed.), Kluwer Academic Publisher, New York, 2003.

6.

Kameneva MV, HS Borovetz, JF Antaki, P Litwak, WJ Federspiel, RL Kormos, BP Griffith. Effect of Perfluorochemical Emulsion on Hemorheology and Shear Induced Blood Trauma: Possible Mechanisms and Future Applications. In: Oxygen Transport to Tissue XVIII, Nemota and LaManna (eds.), Plenum Press, New

JF Antaki, pg 28 of 62

York, pp 383-390, 1997 7.

Yamazaki, K., Kameneva, M., Wagner, W., Antaki, J., Tatka, J., Kerrigan, J., ... & Kormos, R. (1996). Bearing seizure in a rotational blood pump: Mechanism and potential solutions. In Heart Replacement (pp. 371-376). Springer Japan. Chicago

ARCHIVAL PEER-REVIEWED PUBLICATIONS (2004-pres) (NIH format, * indicates notable publication)

In Preparation 1.

Daly, A, SJ Hund, MV Kameneva, et al., Mechanisms of flow induced blood trauma: cell-cell interaction and viscosity.

2.

Kim, J, M Massoudi, [SJ Hund] J Antaki, 3-D two-phase blood flow in an expansion channel, in preparation.

3.

Kim, J, J Wu, J Antaki, Stator optimization of the PediaFlow ventricular assist device, in preparation.

4.

Kim, J, M Massoudi, J Antaki, On Coefficients of the Interaction Forces in Multicomponent Blood Flow, in preparation.

5.

Hund, SJ and JF Antaki, Towards a Rational Model of Shear Induced Blood Trauma Part I: Model Development and Mathematical Integrity. to be submitted Mathematics in Biology.

6.

Hund, SJ and JF Antaki, Comparison of Eulerian and Lagrangian Methods for Optimizing Blood-Wetted Medical Devices for Blood Damage. to be submitted Int J AO.

In Review 7.

Salazar, F.A., et al., Numerical Study of Turbulence Models in the Computation of Blood Flow in Cannulas and Capillary Tubes. Submitted ASME J Turbomachinery.

8.

Salazar, Felix A., Luis R. Rojas-Solórzano, and James F. Antaki. "Numerical Study of Turbulence Models in the Computation of Blood Flow in Cannulas." ASME.

9.

Shu, F, R Tian, S Vandenberghe, and JF Antaki. (2015). Experimental study of micro-scale Taylor vortices within a co-axial mixed-flow blood pump, Cardiovascular Engineering and Technology. In review.

Accepted for Publication Published 2016 10. Kim, J, JF Antaki, and M Massoudi. "Computational study of blood flow in microchannels." Journal of Computational and Applied Mathematics 292 (2016): 174-187. 2015 11. Wu, W. T., Yang, F., Antaki, J. F., Aubry, N., & Massoudi, M. (2015). Study of blood flow in several benchmark micro-channels using a two-fluid approach. International journal of engineering science, 95, 49-59. 12. Yang, F, RL Kormos, and JF Antaki. High-speed visualization of disturbed pathlines in axial flow ventricular assist device under pulsatile conditions. The Journal of Thoracic and Cardiovascular Surgery (Accepted 6.21.2015). 13. Shu, F., Vandenberghe, S., Brackett, J., & Antaki, J. F. (2015). Classification of Unsteady Flow Patterns in a Rotodynamic Blood Pump: Introduction of Non-Dimensional Regime Map. Cardiovascular Engineering and Technology, 6(3), 230-241. 14. Loghmanpour, N. A., Antaki, J. F., & Eckman, P. M. (2015). A Patient-Specific Risk Model for Predicting Major Bleeding, Thromboembolic Events and Mortality After a Continuous Flow Left Ventricular Assist Device (CF-LVAD). The Journal of Heart and Lung Transplantation, 34(4), S232-S233.

JF Antaki, pg 29 of 62

15. Loghmanpour, N. A., Kormos, R. L., Kanwar, M. K., Teuteberg, J. J., Murali, S., & Antaki, J. F. (2015). Modeling the Spectrum of Right Ventricular Failure (RVF) After LVAD Therapy. Journal of Heart and Lung Transplantation, 4(34), S112. 16. Loghmanpour, N. A., Kanwar, M. K., Druzdzel, M. J., Benza, R. L., Murali, S., & Antaki, J. F. (2015). A new Bayesian network-based risk stratification model for prediction of short-term and long-term LVAD mortality. ASAIO Journal, 61(3), 313-323. 17.

Jamiolkowski, MA, Woolley, JR, Kameneva, MV, Antaki, JF, & Wagner, W. R. (2015). Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces. Journal of Biomedical Materials Research Part A, 103(4), 1303-1311.

18.

Montidoro, T. A., Burgess, J. E., & Antaki, J. F. (2015). Characterizing Pressure and Flow Rate for Aqueous Immersion Surgery. Surgical innovation, 1553350615585415, first published on May 12, 2015

2014 19.

Loghmanpour, N. A., Druzdzel, M. J., & Antaki, J. F. (2014). Cardiac Health Risk Stratification System (CHRiSS): A Bayesian-Based Decision Support System for Left Ventricular Assist Device (LVAD) Therapy. PLoS One. 2014 Nov 14;9(11):e111264. PMID: 25397576

20.

Loghmanpour, N. A., Kanwar, M. K., Benza, R. L., Murali, S., & Antaki, J. F. (2014). Development of Predictive Models for Continuous Flow Left Ventricular Assist Device Patients using Bayesian Networks. International Journal of Statistics in Medical Research, 3(4), 423-434.

21.

Jahren, S. E., Ochsner, G., Shu, F., Amacher, R., Antaki, J. F., & Vandenberghe, S. (2014). Analysis of Pressure Head‐Flow Loops of Pulsatile Rotodynamic Blood Pumps. Artificial organs, 38(4), 316-326.

22.

Wu, W. T., Aubry, N., Massoudi, M., Kim, J., & Antaki, J. F. (2014). A numerical study of blood flow using mixture theory. International journal of engineering science, 76, 56-72.

23.

Wang Y, Loghmanpour N, Vandenberghe S, Ferreira A, Keller B, Gorcsan J, Antaki J. Simulation of dilated heart failure with continuous flow circulatory support. PloS one. 2014; 9:e85234; PMID: 24465511 Free PMC Article

2013 24.

Hayden JA, Pantalos GM, Burgess JE, Antaki JF. A hermetically sealed, fluid-filled surgical enclosure for microgravity. Aviat Space Environ Med 2013; 84:1–6.

25.

Amacher, R, H Brinks, A Weber, S Axiak, A Ferreira, J Antaki, T Carrel, L Guzzella1 and S Vandenberghe, Control of ventricular unloading using an ECG-synchronized Thoratec PVAD, Journal of Thoracic and Cardiovascular Surgery, J Thorac Cardiovasc Surg 2013; 146(3):710-717, PMID: 23317942

26.

Menon, P. G., Antaki, JF, Undar, A., & Pekkan, K. (2013). Aortic outflow cannula tip design and orientation impacts cerebral perfusion during pediatric cardiopulmonary bypass procedures. Annals of biomedical engineering, 41(12), 2588-2602.

2012 27.

Massoudi, M, J Kim, JF Antaki, Modeling and numerical simulation of blood flow using the theory of interacting continua. International Journal of Non-Linear Mechanics, 2012 June 1; 47(5): 506–520.

28.

Wu, J., Antaki, J. F., Verkaik, J., Snyder, S., & Ricci, M. (2012). Computational fluid dynamics-based design optimization for an implantable miniature maglev pediatric ventricular assist device. Journal of fluids engineering, 134(4).

29.

Wang, Y., Simon, M. A., Bonde, P., Harris, B. U., Teuteberg, J. J., Kormos, R. L., & Antaki, J. F. (2012). Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device. The Journal of Heart and Lung Transplantation, 31(2), 140-149. NIHMSID: NIHMS344090, PMID:22168963

30.

Ruder, RC, ED Pratt, S Bakhru, M Sitti, S Zappe, JF Antaki, and PR Leduc, Three-Dimensional Microfiber Devices that Mimic Physiological Environments to Probe Cell Mechanics and Signaling. Lab

JF Antaki, pg 30 of 62

on a Chip 2012, 1775-1779 31.

Ferreira, A. L., Yu, Y. C., Arnold, D. K., Vandenberghe, S., Grashow, J., Kitano, T., ... & Antaki, J. F. (2012). In vitro hemodynamic evaluation of ventricular suction conditions of the EVAHEART ventricular assist pump. International journal of artificial organs, 35(4), 263-271.

32.

Kim, J., Massoudi, M., Gandini, A., Antaki, J., Removal of malaria-infected red blood cells using magnetic cell separators: A computational, the Applied Mathematics and Computation, 2011, Volume 218, Issue 12, 15 February 2012, Pages 6841–6850.

33.

Wang, Y, M Simon, P Bonde, B Harris, J Teuteberg, RL Kormos, and JF Antaki, Prognosis of right ventricular failure in patients with left ventricular assisted device based on decision tree with SMOTE, IEEE Transactions on Information Technology in BioMedicine, May 2012, 16 (3): 383-390

2011 34.

*Antaki, JF. The insanity of ventricular assist devices: Doing the same thing and expecting different results. Circulation Heart Failure 4: 680-681, 2011. PMID: 22086829, NIHMSID #343388

35.

Vandenberghe, S, JF Antaki, D Arnold, and F Shu, A simple, economical, and effective portable pediatric mock circulatory system, JEIM, 225 Issue 7 July 2011 pp. 648 – 656

36.

Maul, TM, E Kocyildirim, CA Johnson, AR Daly, SE Olia, JR Woolley, S Snyder, SG Bengston, MV Kameneva and JF Antaki, et al, In Vitro and In Vivo Performance Evaluation of the Second Developmental Version of the PediaFlow Pediatric Ventricular Assist Device, Cardiovascular Engineering and Technology 2(4): 253-262, 2011

37.

Cleveland, J, DC Naftel, RT Brett, M Murray, J Antaki, FD Pagani Francis D. and JK Kirklin, Survival after biventricular assist device implantation: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database, The Journal of heart and lung transplantation 30(8): 862-869, 2011

38.

Gwak, K-W, JF Antaki, BE Paden, and BH Kang, Safety-enhanced optimal control of turbodynamic blood pumps, Artificial Organs, 35:725–732. 2011

39.

Bachman T, JK Bhama, J Verkaik, S Vandenberghe, RL Kormos, JF Antaki, In Vitro Evaluation of Ventricular Cannulation for Rotodynamic Cardiac Assist Devices. Cardiovascular Engineering and Technology 2(3):203-211, 2011.

40.

Johnson C, S Vandenberghe, AR Daly, JR Woolley, ST Snyder, JE Verkaik, S-H Ye, HS Borovetz, JF Antaki, PD Wearden, MV Kameneva1 and WR Wagner, Biocompatibility assessment of the first generation PediaFlow(tm) pediatric ventricular assist device. Artificial Organs 35(1):9-21, 2011. PMID: 20626737

2010 41.

Hund, SJ, JF Antaki, and M Massoudi, On the representation of turbulent stresses for computing blood damage. International Journal of Engineering Science 48 (2010) 1325–1331. (Special Issue in Honor of K.R. Rajagopal)

42.

Zhao R; Marhefka JN; Antaki JF; Kameneva MV, Drag-reducing polymers diminish near-wall concentration of platelets in microchannel blood flow. Biorheology 2010;47(3):193-203. PMID: 21084744

43.

Cleveland, J, TB Reece, DC Naftel, JF Antaki, et al. Decreased Survival after Bi-VAD Implant: Is It the Bi-VAD or the Patient The Journal of Heart and Lung Transplantation, 2010

44.

Gwak KW, BE Paden, JF Antaki, and IS Ahn, Experimental verification of the feasibility of the cardiovascular impedance simulator, IEEE Trans Biomed Eng, vol. 57, pp. 1176-83, May 2010

45.

*Santelices LC, Wang Y, Severyn D, Druzdzel MJ, Kormos RL, Antaki JF. Development of a hybrid decision support model for optimal ventricular assist device weaning. The Annals of thoracic surgery 2010;90(3):713-20. PMID: 20732482

46.

*Antaki, JF, MR Ricci, JE Verkaik, ST Snyder, TM Maul, J Kim, D Paden, BE Paden, and HS Borovetz

JF Antaki, pg 31 of 62 PediaFlow™ Maglev Ventricular Assist Device: A Prescriptive Design Approach. Cardiovascular Engineering Technology 1(1), March, 2010, 104-121. PMID: 20544002, PMC2882700 2009 47.

MA Simaan, A Ferreira, S Chen, JF Antaki, DG Galati, A dynamical state space representation and performance analysis of a feedback-controlled rotary left ventricular assist device. IEEE Transactions On Control Systems Technology, 17(1): 15-28, 2009.

48.

*Wu J, Paden BE, Borovetz HS, Antaki JF. Computational fluid dynamics analysis of blade tip clearances on hemodynamic performance and blood damage in a centrifugal ventricular assist device. Artificial Organs 2009. PMID:19832736

49.

*Hund SJ, Antaki JF. An extended convection diffusion model for red blood cell-enhanced transport of thrombocytes and leukocytes. Physics in medicine and biology 2009;54(20):6415-35.PMID:19809124

50.

*Shu F, Vandenberghe S, Antaki JF. The importance of dQ/dt on the flow field in a turbodynamic pump with pulsatile flow. Artificial organs 2009;33(9):757-62.PMID:19775268

51.

Marhefka JN, Zhao R, Wu ZJ, Velankar SS, Antaki JF, Kameneva MV. Drag reducing polymers improve tissue perfusion via modification of the RBC traffic in microvessels. Biorheology 2009;46(4):281-92. PMID:19721190

52.

*Bhama JK, Bachman TN, Kormos RL, Borovetz H, Antaki JF. Development of an ex vivo ovine ventricular assist device model for intraventricular visualization of the inflow cannula. J Heart Lung Transplant 2009;28(8):860-1.PMID:19632587

53.

Kim NJ, Diao C, Ahn KH, Lee SJ, Kameneva MV, Antaki JF. Parametric study of blade tip clearance, flow rate, and impeller speed on blood damage in rotary blood pump. Artificial organs 2009;33(6):468-74. PMID:19473143

54.

*Shu F, Parks R, Maholtz J et al. Multimodal flow visualization and optimization of pneumatic blood pump for sorbent hemodialysis system. Artif Organs 2009; 33 (4):334-45. PMID:19335410

55.

*Ferreira A, Boston JR, Antaki JF. A control system for rotary blood pumps based on suction detection. IEEE transactions on bio-medical engineering 2009;56(3):656-65.PMID:19272919

56.

Simaan, MA; Ferreira, A; Chen, SH; Antaki, JF; Galati, DG, A Dynamical State Space Representation and Performance Analysis of a Feedback-Controlled Rotary Left Ventricular Assist Device, IEEE Transactions On Control Systems Technology 2009; 17 (1): 15-28.

57.

*Gottlieb RK, F. Shu, MV Kameneva, JF Antaki, Z Wu, GW Burgreen. Liquid crystal shear stress sensor for blood and other opaque viscous fluids, Journal of Flow Visualization and Image Processing. 2009; 16(9): 51-72

58.

*Massoudi, M., and Antaki, J. F., 2008. An Anisotropic Constitutive Equation for the Stress Tensor of Blood Based on Mixture Theory. Mathematical Problems in Engineering 2008, 1-31.

59.

*Antaki JF, Diao CG, Shu FJ et al. Microhaemodynamics within the blade tip clearance of a centrifugal turbodynamic blood pump. Proc Inst Mech Eng H 2008b; 222 (4):573-81. PMID: 18595366

60.

*Zhao R, Marhefka JN, Shu F et al. Micro-flow visualization of red blood cell-enhanced platelet concentration at sudden expansion. Ann Biomed Eng 2008; 36 (7):1130-41. (PMID: 18418710).

61.

Noh MD, Antaki JF, Ricci M, Gardiner J, Paden D, Wu J, Prem E, Borovetz H, Paden BE. Magnetic design for the PediaFlow ventricular assist device. Artif Organs. Feb 2008;32(2):127-135.

62.

Samiappan, C, N Mimateghi, BE Paden, and JF Antaki, Maglev apparatus for power minimization and control of artificial hearts, IEEE Trans System Control Technology, 16(1) 13-18, 2008.

63.

Zhao R, MV Kameneva, and JF Antaki. Investigation of platelet margination phenomena at elevated shear stress. Biorheology. 2007; 44(3):161-177. PMID: 17851165

64.

Choi S, JR Boston, and JF Antaki. Hemodynamic controller for left ventricular assist device based on

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pulsatility ratio. Artificial organs. Feb 2007; 31(2):114-125. 65.

Gardiner JM, Wu J, Noh MD, Antaki JF, Snyder TA, Paden DB, Paden BE. Thermal Analysis of the PediaFlow pediatric ventricular assist device. ASAIO J. Jan-Feb 2007;53(1):65-73.

66.

Lee SS, Antaki JF, Kameneva MV, Ahn KH, Lee SJ. Strain hardening of red blood cells by accumulated cyclical supraphysiological stress. Artificial Organs, 31(1):80-86, 2007.

67.

Zhao R, Antaki JF, Naik T, Bachman TN, Kameneva MV, Wu ZJ. Microscopic investigation of erythrocyte deformation dynamics. Biorheology. 2006;43(6):747-765.

68.

Uber BE, Webber SA, Morell VO, Antaki JF. Hemodynamic guidelines for design and control of a turbodynamic pediatric ventricular assist device. Asaio J. Jul-Aug 2006;52(4):471-478.

69.

Borovetz HS, Badylak S, Boston JR, Johnson C, Kormos R, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner WR, Woolley J, Antaki J, Diao C, Vandenberghe S, Keller B, Morell V, Wearden P, Webber S, Gardiner J, Li CM, Paden D, Paden B, Snyder S, Wu J, Bearnson G, Hawkins JA, Jacobs G, Kirk J, Khanwilkar P, Kouretas PC, Long J, Shaddy RE. Towards the development of a pediatric ventricular assist device. Cell transplantation. 2006;15 Suppl 1:S69-74.

70.

Wearden PD, Morell VO, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos RL, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B, Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, Shaddy RE. The PediaFlow pediatric ventricular assist device. Seminars in thoracic and cardiovascular surgery. 2006:92-98.

71.

Vandenberghe S, Segers P, Steendijk P, Meyns B, Dion RA, Antaki JF, Verdonck P. Modeling ventricular function during cardiac assist: does time-varying elastance work Asaio J. Jan-Feb 2006;52(1):4-8.

72.

Lee SS, NJ Kim, K. Sun, J.G. Dobbe, M.R. Hardeman, J.F. Antaki, K.H. Ahn, S.J. Lee. Association between arterial stiffness and the deformability of red blood cells (RBCs). Clinical Hemorheology and Microcirculation. 34(4): 475 – 481, 2006. PMID: 17209965

73.

Gwak KW, BE Paden and JF Antaki. Fluidic operational amplifier for mock circulatory systems, IEEE Trans. Control Systems Technologies, 14(4):602-612, 2006.

74.

Vandenberghe S, P Segers, J Antaki, R Shihab and P Verdonck. In Vitro Evaluaion of Pulsatile use fo the New Medos Deltastream Pump. ASAIO Journal. 51(2):43A, March/April 2005.

75.

*Wu, J, C Diao, WR Wagner, TA Snyder, HS Borovetz, BE Paden, and JF Antaki. Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by CFD-based design ASAIO J, 51(5):63643, 2005.

76.

Vandenberghe, S, P Segers, JF Antaki, B Meyns, and PR Verdonck, Hemodynamic modes of ventricular assist with a rotary blood pump: Continuous, pulsatile, and failure, ASAIO Journal 2005; 51(6):711–718.

77.

Choi S, Boston JR, Antaki JF. An investigation of the pump operating characteristics as a novel control index for LVAD control. International Journal of Control Automation and Systems. Mar 2005;3(1):100108.

78.

Gwak, KW, M Ricci, S Snyder, BE Paden, JR Boston, MA Simaan, and JF Antaki, In-Vitro evaluation of multi-objective hemodynamic control of heart-assist pump. ASAIO J. 2005 Jul-Aug;51(4):329-35.

79.

Wu, J, JF Antaki, TA Snyder, HS Borovetz, BE Paden, Design optimization of blood shearing instrument by computational fluid dynamics. Artificial Organs 29(6):482-489, 2005.

80.

Kameneva MV, Burgreen GW, Kono K, Repko B, Antaki JF, Umezu M. Effects of turbulent stresses upon mechanical hemolysis: experimental and computational analysis. Asaio J. Sep-Oct 2004;50(5):418-423.

81.

Song X, AL Throckmorton, JF Antaki and DB Olsen. Quantitative evaluation of the blood damage in a centrifugal blood pump by computational fluid dynamics. Transactions of the ASME. Journal of Fluids Engineering, v 126, n 3, May 2004, p 410-18

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82.

Song, X, HG Wood, PE Allaire, JF Antaki, and DB Olsen, Inlet and outlet devices for rotary blood pumps, Artif Organs, vol. 28, pp. 911-5, 2004.

83.

Smith WA, P Allaire, J Antaki, KC Butler, W Kerkhoffs, T Kink, H Loree, and H Reul, Collected nondimensional performance of rotary dynamic blood pumps, ASAIO J, vol. 50,(1): 25-32, 2004.

ARCHIVAL PEER-REVIEWED PUBLICATIONS – Pre 2004 84. Paden BE, NJ Groom, JF Antaki. Design formulae for permanent magnet bearings. ASME J Mechanical Design, 125:734-738, 2003. 85. Antaki, JF, JR Boston, and MA Simaan. Control of heart assist: 42nd IEEE International Conference on Decision and Control (IEEE Cat. No.03CH37475), 2003, pt. 4, p 4084-9 vol.4 86. Song X, AL Throckmorton, HG Wood, JF Antaki and DB Olsen. Computational Fluid Dynamics Prediction of Blood Damage in a Centrifugal Pump. Artificial Organs 27(10):938-941, 2003. 87. Chen C, B Paden, J Antaki, J Ludlow, G Bearnson. Optimal design of permanent magnet bearings with application to the HeartQuest Ventricular Assist Device. JSME International Journal, Series C, Vol 46, No.2, pp 403-408, June 2003. 88. Boston JR, JF Antaki, M Simaan. Hierarchical control for artificial hearts. Robotics and Automation Magazine, March 2003. 89. Baloa LA, JR Boston, MA Simaan, and JF Antaki, Performance of an extended certainty weighted detection model, IEEE Transactions on Systems, Man, and Cybernetics, Part A, 2003, 33(1):12-22, January 2003. 90. Chen C, BE Paden, JF Antaki, J Ludlow, DB Paden, R Crowson, G Bearnson. A magnetic suspension theory and its application to the HeartQuestTM MagLev VAD. Artificial Organs, 26(11): 947-951, 2002. 91. Antaki J, S Banda, B Paden, Ml Piovoso. Award Winning Control Applications IEEE Control Systems Magazine, Michael K. Masten (ed.), Vol. 22:6, December 2002, pp 8-20. 92. Yu Y-C, JR Boston, M Simaan, JF Antaki. Minimally invasive estimation of systemic cardiovascular parameters for artificial heart control. Control Engineering Practice, 10:277-285, 2002. 93. Burgreen GW, JF Antaki, ZJ Wu, AJ Holmes. Computational fluid dynamics as a development tool for rotary blood pumps. Artificial Organs, 25(5):336-40, May 2001. 94. Wu ZJ, RK Gottlieb, GW Burgreen, JA Holmes, DC Borzelleca, MV Kameneva, BP Griffith, JF Antaki. Investigation of fluid dynamics within a miniature mixed flow blood pump. Experiments in Fluids 31(6): 615-629, 2001. 95. Griffith BP, RL Kormos, HS Borovetz, K Litwak, JF Antaki, V Poirier, KC Butler. The Heartmate II left ventricular assist system: From concept to first clinical use. Ann Thoracic Surgery, 71(3): S116-S120, 2001. 96. Yu Y-C, JR Boston, MA Simaan, JF Antaki. Minimally invasive estimation of systemic vascular parameters. Annals of Biomedical Engineering, 29(7):595-606, 2001. 97. Yu Y-C, JR Boston, M Simaan, P Miller, JF Antaki. Pressure-volume relationship of pulsatile blood pump for ventricular assist device development. ASAIO J, 47(3): 293-301, 2001. 98. Baloa LA, JR Boston, JF Antaki. Elastance based control of a mock circulatory system. Ann Biomed Eng, 29(3), 244-251, 2001. 99. Choi S, JF Antaki, JR Boston, D Thomas. A sensorless approach to control of a turbodynamic left ventricular assist system. IEEE Trans on Control Systems Technology, 9(3):473-482, 2001. 100. Akimoto T, K Yamazaki, P Litwak, K Litwak, O Tagusari, T Mori, JF Antaki, M Kameneva, M Watach, M Umezu, J Tomioka, RK Kormos, H Koyanagi, BP Griffith. Relationship of blood pressure and pump flow in an implantable centrifugal blood pump during hypertension. ASAIO J, 46(5): 596-599, 2000. 101. Akimoto T, K Yamazaki, P Litwak, KN Litwak, O Tagusari, T Mori, JF Antaki, MV Kameneva, MJ Watach,

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M Umezu, J Tomioka, RL Kormos, H Koyanagi, BP Griffith. Continuously maintaining positive flow avoids endocardial suction of a rotary blood pump with left ventricular bypass. Artificial Organs, 24(8):606-610, 2000. 102. Antaki JF, GE Blelloch, O Ghattas, I Malcevic, GL Miller, NJ Walkington. A parallel dynamic-mesh Lagrangian method for simulation of flows with dynamic interfaces. Supercomputing Conference 2000, In Proceedings of SC 2000,11, Dallas, Texas, USA, November 4-10, 2000. 103. Kameneva MV, A Undar, JF Antaki, MJ Watach, JH Calhoon, and HS Borovetz. Decrease in red blood cell deformability caused by hypothermia, hemodilution, and mechanical stress: factors related to cardiopulmonary bypass. ASAIO J, 45:307-310, 1999. 104. Kameneva MV, MJ Watach, P Litwak, JF Antaki, KC Butler, D Thomas, LP Taylor, HS Borovetz, RL Kormos, BP Griffith. Chronic animal health assessment during axial ventricular assistance: importance of hemorheological parameters. ASAIO Journal, 45(3):183-188, 1999. 105. Burgreen GW, JF Antaki, J Wu, P LeBlanc, KC Butler. A computational and experimental comparison of two outlet stators for the Nimbus LVAD. ASAIO J, 45:328-333, 1999. 106. Wu Z, JF Antaki, GW Burgreen, KC Butler, DC Thomas, BP Griffith. Fluid dynamic characterization of operating conditions for continuous flow blood pumps. ASAIO J, 45:442-449, 1999. 107. Sorensen EN, GW Burgreen, WR Wagner, JF Antaki. Computational simulation of platelet deposition and activation I: Model equations and properties. Ann Biomed Eng, 27(4):436-448, 1999. 108. Sorensen EN, GW Burgreen, WR Wagner, JF Antaki. Computational simulation of platelet deposition and activation II: Results for Poiseuille flow over collagen. Ann Biomed Eng, 27(4):449-458, 1999. 109. Kameneva MV, MJ Watach, P Litwak, JF Antaki, KC Butler, DC Thomas, LP Taylor, HS Borovetz, RL Kormos, BP Griffith. Chronic animal health assessment during axial ventricular assistance: Importance of hemorheological parameters. ASAIO J, 45(3):183-188, 1999. 110. Yu Y-C, JR Boston, MA Simaan, PJ Miller and JF Antaki. Modeling and simulation of a blood pump for the development of a left ventricular assist system controller. Kybernetica, 35(5):651-664, 1999. 111. Tagusari O, K Yamazaki, P Litwak, A Kojima, EC Klein, JF Antaki, M Watach, LM Gordon, K Kono, T Mori, H Koyanagi, BP Griffith, RL Kormos. Fine trabecularized carbon: Ideal material and texture for percutaneous device system of permanent left ventricular assist device. Artificial Organs, 22(6):481-487, 1998. 112. Yeleswarapu KK, MV Kameneva, KR Rajagopal, JF Antaki. The flow of blood in tubes - theory and experiment. Mechanics Research Communications, 25(3): 257-262, 1998. 113. Bahnson HT, JF Antaki, Q Beery. Acoustic and physical dynamics of the diatonic harmonica. J Acoust. Soc. Am, 103, (4):2134-2144, 1998. 114. Yamazaki K, T Mori, J Tomioka, P Litwak, JF Antaki, O Tagusari, H Koyanagi, BP Griffith, RL Kormos. The cool-seal system: a practical solution to the shaft seal problem and heat related complications with implantable rotary blood pumps. ASAIO J, 43:5:M567-M571, 1998. 115. Yamazaki K, P Litwak, RL Kormos, T Mori, O Tagusari, JF Antaki, M Kameneva, M Watach, L Gordon, M Umezu, J Tomioka, H Koyanagi, BP Griffith. An implantable centrifugal blood pump for long term circulatory support. ASAIO J, 43(5):M686-M691, 1998. 116. Yamazaki K, RL Kormos, P Litwak, O Tagusari, T Mori, JF Antaki, M Kameneva, M Watach, L Gordon, H Mukuo, M Umezu, J Tomioka, E Outa, BP Griffith, H Koyanagi. Long term experiments with an intraventricular axial flow blood pump. ASAIO J, 43(5):M696-M700, 1998. 117. Kameneva, MV, J Antaki, KK Yeleswarapu, MJ Watach, BP Griffith, and HS Borovetz. Plasma protective effect on red blood cells exposed to mechanical stress. ASAIO J 43(5), M571-5 1997. 118. Yamazaki K, P Litwak, O Tagusari, T Mori, K Kono, M Kameneva, M Watach, L Gordon, M Miyagishima, J Tomioka, M Umezu, E Outa, JF Antaki, RL Kormos, H Koyanagi, and BP Griffith. An implantable

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centrifugal blood pump with a recirculating purge system (Cool-seal system). Artificial Organs, 22(6):481487, 1998. 119. Tagusari, O, K Yamazaki, P Litwak, JF Antaki, M Watach, LM Gordon, K Kono, T Mori, H Koyanagi, BP Griffith, and RL Kormos. Effect of pressure-flow relationship of centrifugal pump on in vivo hemodynamics: a consideration for design. Artif. Organs 22(5): 399-404, 1998. 120. Amin DV, JF Antaki, P Litwak, D Thomas, ZJ Wu, M Watach. Induction of ventricular collapse by an axial flow blood pump. ASAIO J, 44(5): M685-M690, 1998. 121. Curtis A, J Wu, RL Kormos, JF Antaki. A novel ventricular apical cannula: In vitro evaluation using transparent, compliant cast. ASAIO J, 44(5): M691-M695, 1998. 122. Yu Y-C, JR Boston, M Simaan, JF Antaki. Estimation of systemic vascular bed parameters for artificial heart control. IEEE Transactions on Automatic Control: Special Issue on Biomedical Applications of Control, 43(6): 765-778, 1998. 123. Butler, K, D Thomas, J Antaki, H Borovetz, B Griffith, M Kameneva, R Kormos, and P Litwak. Development of the Nimbus/Pittsburgh axial flow left ventricular assist system. Artif Organs 21(7): 602-610, 1997. 124. Macha, M, P Litwak, K Yamazaki, M Kameneva, JP Kerrigan, JF Antaki, KC Butler, DC Thomas, LP Taylor, RL Kormos, BP Griffith, and HS Borovetz. Survival for up to six months in calves supported with an implantable axial flow ventricular assist device. ASAIO J 43(4): 311-3115, 1997, 125. Kameneva MV, HS Borovetz, JF Antaki, P Litwak, WJ Federspiel, RL Kormos, BP Griffith. Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma. . Possible mechanisms and future applications. Adv Exp Med Biol, 411:383-390, 1997.. 126. Kameneva, MV, HS Borovetz, JF Antaki, P Litwak, WJ Federspiel, RL Kormos, and BP Griffith. Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma. Possible mechanisms and future applications. Adv Exp Med Biol 411:383-390, 1997. 127. Amin DV, JF Antaki, P Litwak, D Thomas, Z Wu, Y-C Yu, S Choi, JR Boston, and BP Griffith. Controller for an axial-flow blood pump. Biomed Instrument Technol, 31(5):483-487, 1997. 128. Konishi H, MJ Yland, M Brown, K Yamazaki, M Macha, R Konishi, JP Kerrigan, S Zhang, PS Randhawa, JF Antaki, K Fuse, RL Kormos. Effect of pulsatility and hemodynamic power and recovery of renal function. ASAIO J, 42:M720-M723, 1996. 129. Burgreen GW, JF Antaki, BP Griffith. A design improvement strategy for axial blood pumps using computational fluid dynamics. ASAIO Journal, 42(5):M354-M360, 1996. 130. Konishi H, JF Antaki, P Litwak, M Kameneva, K Yamazaki, M Macha, JP Kerrigan, WA Mandarino, KC Butler, HS Borovetz, RL Kormos. Long-term animal survival with an implantable axial flow pump as a left ventricular assist device. Artificial Organs, 20(2):124-127, 1996. 131. Konishi, H, J Antaki, D Amin, JR Boston, JP Kerrigan, WA Mandarino, P Litwak, K Yamazaki, M Macha, KC Butler, HS Borovetz, and RL Kormos. Controller for an axial flow blood pump. Artif Organs 20(6): 618620, 1996. 132. Labadie RF, JF Antaki, JL Williams, S Katyal, J Ligush Jr., SC Watkins, SM Pham, HS Borovetz. Pulsatile perfusion system for ex-vivo investigation of biochemical pathways in intact vascular tissue. Am. J. Physiol 270 (Heart Circ. Physiol. 39), 270(2) Part2: H760-H768, 1996. 133. Kerrigan JP, K Yamazaki, RK Meyer, T Mori, Y Otake, E Outa, M Umezu, HS Borovetz, RL Kormos, BP Griffith, H Koyanagi, JF Antaki. High resolution fluorescent particle tracking flow visualization within an intra-ventricular axial flow left ventricular assist device. Artificial Organs, 20(6):534-540, 1996. 134. Kameneva MV, JF Antaki, HS Borovetz, BP Griffith, KC Butler, KK Yeleswarapu, MJ Watach, RL Kormos. Mechanisms of red blood cell trauma in assisted circulation. Rheologic similarities of red blood cell transformations due to natural aging and mechanical stress. ASAIO J, 41(3):M457-M460, 1995. 135. Antaki JF, GE Bertocci, EC Green, A Nadeem, T Rintoul, RL Kormos, BP Griffith. A gait-powered

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autologous battery charging system for artificial organs. ASAIO J, 41(3):M588-M595, 1995 (Recipient of ASAIO/Medforte Innovation Award). 136. Yamazaki K, M Kameneva, J Antaki, J Kerrigan, P Litwak, H Konishi, M Macha, H Borovetz, T Mori, M Umezu, H Koyanagi, R Kormos, J Tomczak, E Outa.. An intraventricular axial flow blood pump integrated with a bearing purge system. ASAIO J 41(3): M327-M332, 1995. 137. Antaki JF, O Ghattas, GW Burgreen, B He. Computational flow optimization in rotary blood pump components. Artificial Organs, 19(7):608-615, 1995. 138. Yeleswarapu KK, JF Antaki, MV Kameneva, KR Rajagopal. A mathematical model for shear-induced hemolysis. Artificial Organs, 19(7):576-682, 1995. 139. Antaki JF, TJ Dennis, H Konishi, ME Brown, TR Maher, JP Tomczak, JP Kerrigan, RL Kormos,. An improved left ventricular cannula for chronic dynamic blood pump support. Artificial Organs, 19(7):671675, 1995. 140. Konishi H, JF Antaki, JR Boston, JP Kerrigan, WA Mandarino, K Yamazaki, M Oe, P Litwak, HS Borovetz, KC Butler, RL Kormos. Dynamic systemic vascular resistance in a sheep supported with a Nimbus AxiPump. ASAIO J, 40(3):M299-M302, 1994. 141. Kameneva MV, JF Antaki, H Konishi, JH Whalen, JP Kerrigan, MJ Watach, RL Kormos, BP Griffith, HS Borovetz. Effect of perfluorochemical emulsion on blood trauma and hemorheology. ASAIO J, 40:M576M579, 1994. 142. Kameneva MV, JF Antaki, MJ Watach, HS Borovetz, RL Kormos. Heparin effect on red blood cell aggregation. Biorheology, 31(3):297-304, 1994. 143. Antaki JF, KC Butler, RL Kormos, A Kawai, H Konishi, JP Kerrigan, HS Borovetz, TR Maher, MV Kameneva, BP Griffith. In-vivo evaluation of the Nimbus axial flow ventricular assist system: Criteria and Methods. ASAIO J, 39(3):M231-M236, 1993. 144. Kerrigan JP, FD Shaffer, TR Maher, TJ Dennis, HS Borovetz, JF Antaki. Fluorescent image tracking velocimetry (FITV) of the Nimbus AxiPump. ASAIO J, 39(3): M639-M643, 1993. 145. Butler KC, TR Maher, HS Borovetz, RL Kormos, JF Antaki, MV Kameneva, BP Griffith, T Zerbe, FD Schaffer. Development of an axial flow blood pump LVAS. ASAIO J, 38(3) :M296-M300, 1992. 146. Antaki JF. An Experimental and Theoretical Model for the Passive Biomechanical Properties of the Intact Heart (Volumes I and II). PhD Thesis, University of Pittsburgh, Dept. of Mechanical Engineering, 1991. 147. Kormos RL, HS Borovetz, T Gasior, JF Antaki, JM Armitage, JM Pristas, RL Hardesty, BP Griffith. Experience with univentricular support in mortally ill cardiac transplant candidates. Annals of Thoracic Surgery, 49(2):261-271, 1990. 148. Kormos RL, T Gasior, JF Antaki, JM Armitage, Y Miyamoto, HS Borovetz, RL Hardesty, BP Griffith. Evaluation of right ventricular (RV) function during clinical left ventricular assistance. ASAIO Transactions, 35(3):547-550, 1989. 149. Cherup LL, JF Antaki, MD Liang, RS Hamas. Measurement of capsular contracture: The conventional breast implant and the Pittsburgh implant. Plastic and Reconstructive Surgery, 84(6):893-901, 1989. Refereed Conference Proceedings – (2004-pres) 2015 150.

Loghmanpour, N. A., Antaki, J. F., & Eckman, P. M. (2015). A Patient-Specific Risk Model for Predicting Major Bleeding, Thromboembolic Events and Mortality After a Continuous Flow Left Ventricular Assist Device (CF-LVAD). The Journal of Heart and Lung Transplantation, 34(4), S232-S233.

151.

Loghmanpour, N. A., Kormos, R. L., Kanwar, M. K., Teuteberg, J. J., Murali, S., & Antaki, J. F. (2015). Modeling the Spectrum of Right Ventricular Failure (RVF) After LVAD Therapy. Journal of Heart and Lung Transplantation, 4(34), S112.

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2014 152.

Blank, M., & Antaki, J. F. (2014, October). Low-cost quantitative palpation device for breast lesion tracking and telehealth. In Healthcare Innovation Conference (HIC), 2014 IEEE (pp. 280-283). IEEE.

153.

Loghmanpour N, Kanwar M, Bailey S, Benza R, Murali S, Antaki J. Development of a novel predictive model for mortality post continuous flow LVAD implant using Bayesian Networks (BN): the first application to the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database. ISHLT 34th Annual Meeting and Scientific Sessions, April 10-13, 2014 in San Diego. (Podium presentation.) The Journal of Heart and Lung Transplantation, 33(4), S74.

154.

Wu, W-T, A Martin, J Kim, JF Antaki, N Aubry, M Massoudi. Theoretical and numerical study on a magnetic malaria-infected red blood cell separator . The 2014 Midwest regional meeting of the American Society of Biomechanics, March 2014, www.uakron.edu/ASB2014.

155.

Wu, W-T, N Aubry, JF Antaki, M Massoudi, Study of blood flow in micro-channels using mixture theory. Proceedings of the ASME 2014 Fluids Engineering Summer Meeting (2014 FEDSM/ICNMM), Chicago. http://www.asmeconferences.org/FEDSM2014/

156.

Loghmanpour N, Kanwar M, Benza R, Antaki J, Murali S. A predictive model for mortality post continuous flow LVAD implant using Bayesian analysis: the first application to the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) registry database. American Heart Association Fellows Research Day, February 14, 2014.

2013 157.

Kanwar, M., Loghmanpour, N., Wang, Y., Snyder, T., Horstmanshof, D., Long, J., ... & Murali, S. (2013). A novel, risk stratification model using bayesian networks for continuous-flow left ventricular assist device 90-day survival. Journal of the American College of Cardiology, 61(10_S).

158.

Loghmanpour, N. A., Kanwar, M. K., Wang, Y., Snyder, T. A., Horstmanshof, D. A., Long, J. W., ... & Murali, S. (2013). A Novel, Risk Stratification Model Using Bayesian Networks for Continuous Flow Left Ventricular Assist Device 90-Day Survival. The Journal of Heart and Lung Transplantation, 32(4), S232.

2012 2011 159.

Ferriera, AL, et al. Assessment of cardiac function during mechanical circulatory support: the quest for a suitable clinical index, 3rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'11), Boston, MA, USA on August 30 - September 3, 2011.

160.

Wang Y, A Ferreira, BB Keller, M Simon, JF Antaki, Effect of continuous-flow left ventricular assist device on cardiac function: simulation study with a refined computer model, SBC2011-53874, In. Proceedings ASME Summer Bioengineering Conference, Ligonier, June 22-25, 2011.

161.

Ferreira, AL, et al. Assessment of cardiac function during mechanical circulatory support: a simulation study. SBC2011-53735, ibid.

162.

Kim, J., Massoudi, M., Hund, S., Antaki, J., Application of the Theory of Interacting Continua to Blood Flow. SBC2011-53260, ibid.

163.

TM Maul, JF Antaki, Wu, J., Kim, J., MV Kameneva, S OliaE., Wearden, PD, E Kocyildirim, and HS Borovetz. In Silico Design and In Vivo Analysis of the PediaFlowTM Pediatric Ventricular Assist Device. SBC2011-53241, ibid.

2010 164.

Wang, Y…. JF Antaki, Cost-sensitive Decision Tree Model for Optimal Identification of Need for Right Ventricular Support, 10th IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB 2010) Corfu, Greece, 3 –5 November 2010.

165.

Wang, Y., Rosé, C. P., Ferreira, A., McNamara, D. M., Kormos, R. L., & Antaki, J. F. (2010, December).

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A classification approach for risk prognosis of patients on mechanical ventricular assistance. In Machine Learning and Applications (ICMLA), 2010 Ninth International Conference on (pp. 293-298). IEEE. 2009 166.

Ruder, WC, JF Antaki, and PR LeDuc, Engineered Polymer Microenvironments for Probing Ca2+ Mechanotransduction using Dorsal Cell Adhesion.. Engineering Cell Biology III Conference 2009. Poster Presentation.

167.

Simaan, M. A., Ferreira, A., Chen, S., Antaki, J. F., & Galati, D. G. (2009). A dynamical state space representation and performance analysis of a feedback-controlled rotary left ventricular assist device. Control Systems Technology, IEEE Transactions on, 17(1), 15-28.

2008 168.

Ruder, WC, JF Antaki, and PR LeDuc Multimodal Perturbation of Intracellular Calcium using Dorsal Cell Adhesion. Mechanobiology of Cell-Extracellular Matrix Interactions Symposium for the 45th Society of Engineering Science (SES) Annual Technical Meeting 2008. Podium Presentation.

169.

Ruder, WC, Pratt, ED, Cassino, T, Huard, J, Antak, JF, and PR LeDuc Examining Links between Oscillatory Calcium Signal Transduction and Stem Cell Phenotype. BMES Annual Meeting 2008. Podium Presentation.

170.

Ruder, WC, PR LeDuc and JF Antaki, Spatiotemporal Control of Focal Adhesions for Probing Mechanotransduction in Calcium Signaling. BMES Annual Meeting 2008. Poster Presentation.

171.

Ruder, WC, ED Pratt, M Sitti, JF Antaki, and PR LeDuc. Multimodal Perturbation of intracellular Ca2+ using Dorsal Cell Adhesion. Biophysical 52nd Annual Meeting & 16th International Biophysics Congress 2008. Poster Presentation.

172.

R. Zhao, M. Massoudi, S. J. Hund, M. V. Kameneva and J. F. Antaki. Experimental and theoretical investigation of blood microflow dynamics associated with blood contacting devices. S22-4, Abstracts of the 13th International Congress of Biorheology and 6th International Conference on Clinical Hemorheology. Biorheology, Volume 45 (2008), pp. 76-77.

173.

R. Zhao, M. Massoudi, S. J. Hund, and J. F. Antaki. A volume fraction based two-phase constitutive model for blood. Proceedings of the ASME 2008 Summer Bioengineering Conference, SBC2008- 193172, June 25-29, Marriott Resort, Marco Island, Florida, USA.

174.

Felix A. Salazar Luis R. Rojas-Solórzano, JF Antaki, Numerical study of turbulence models in the computation of blood flow in cannulas, Proceedings of FEDSM2008, 2008 ASME Fluids Engineering Conference, August 10-14, 2008, Jacksonville, FL, USA

175.

Ruder, WC, ED Pratt, M Sitti, PR LeDuc and JF Antaki, Investigation Of Calcium Mechanotransduction By Quasi 3-D Microfiber Mechanical Stimulation of Cells. ASME Summer Bioengineering Conference 2008. Podium Presentation.

176.

Scotti, CM, F Shu, S Vandenberghe, J Seong, JF Antaki, BB Lieber (5), and EA Finol, Flow visualization and validation of AAA dynamics: A comparison between CFD, PIV, and FSI, in Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), June 25-29, Marriott Resort, Marco Island, Florida, USA

177.

Drummond, A, Onur Dur, Kerem Pekkan, James Antaki, “ Simulation of Optimal Surgical Anastomosis of Pediatric Aortic Cannula,” ibid.

2007 178.

Ruder, W.C., Pratt, E.D., Brandy, N.Z., LaVan, D.A., JF Antaki and PR LeDuc Probing Intracellular Ca2+ Signaling through Mechanical Stimulation of Focal Adhesion Complexes. BMES Annual Meeting 2007. Podium Presentation.

179.

Ruder, WC, ED Pratt, NZ Brandy, DA. LaVan, PR LeDuc, and JF Antaki. Stretch-activated calcium signal propagation following mechanical stimulation of focal adhesions. Proceedings of the ASME 2007

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Summer Bioengineering Conference (SBC2007), June 20-24, Keystone Resort & Conference Center, Keystone, Colorado, USA 180.

Gwak, K-W and JF Antaki, Hemodynamic optimization of mechanical circulatory assistance using extremum seeking control, American Control Conference (2007 ACC), July 11 to 13, 2007, Times Square, New York, NY.

181.

Ferreira A, Boston JR, Antaki JF. A rule-based controller based on suction detection for rotary blood pumps. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007: 3978-3981.

2006 182.

Antaki, J, D Arnold, T Bachman, G Bearnson, H Borovetz, A Drummond, C Johnson, M Kameneva, B Keller, P Khanwilkar, J Kirk, R Kormos, C-M Li, T Maher, V Morell, B Paden, D Paden, R Shaddy, S Snyder, T Snyder, S Vandenberghe, J Verkaik, W Wagner, P Wearden, J Woolley, J Wu. Development of the PediaFlow ventricular assist device for infants and small children, In Proceedings: Heart Failure in Children, Laguna Beach, CA, Nov 28, 2006

183.

Snyder, T, J Woolley, P Marascalco, J Antaki, William Wagner, Marina Kameneva. Validity of normalized index of hemolysis in pediatric mechanical circulatory assist devices and application to hemolysis testing of five pediatric blood pumps, In Proceedings: Heart Failure in Children, Laguna Beach, CA, Nov 28, 2006

184.

Ferreira, A, M.A. Simaan, J.R. Boston J. F. Antaki "Frequency and time-frequency based indices for suction detection in rotary blood pumps, "

185.

Ferreira, A., M Simaan, JR Boston, and JF Antaki, A discriminant-analysis-based suction detection system for rotary blood pumps. The 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. August 30 - September 3, 2006 New York, New York, USA.

186.

Zhao R, MV Kameneva and JF Antaki, Investigation of device-associated platelet margination using micro flow visualization, ibid.

187.

(Author List) Wu, J and JF Antaki,: Analysis and Optimization of PVAD Impeller, ibid.

188.

Drummond, A, T Bachman, B Keller, and J Antaki, “Three Dimensional Virtual Anatomic Fit Study for an Implantable Pediatric Ventricular Assist Device,” Proceedings for the International Conference on Computational Science. May 2006.

2005 189.

Ferreira, A., M Simaan, JR Boston, and JF Antaki, A Nonlinear State-Space Model of a Combined Cardiovascular System and a Rotary Pump. Joint 44th IEEE Conference on Decision and Control and European Control Conference (CDC-ECC'05) Seville, Spain, on December 12-15, 2005. (peer reviewed)

190.

Noh, D. JF Antaki, E Prem, HS Borovetz, and BE Paden. Magnetic levitation design for the PediaFlow™ ventricular assist device. To appear in: IEEE/ ASME International Conference on Advanced Intelligent Mechatronics (AIM2005); 24-28 July 2005, Monterey, California.

191.

Chen, S, JF Antaki, M A Simaan, JR Boston, Physiological Control of Left Ventricular Assist Devices Based on Gradient of Flow, In Proceedings: 2005 American Control Conference (ACC 2005) June 8 to June 10, 2005, Portland, Oregon. (Archival.)

192.

Samiappan C, N Mirnateghi, BE Paden, JF Antaki. Maglev Apparatus for Power Minimization and Control of Artificial Hearts. Joint 44th IEEE Conference on Decision and Control and European Control Conference (CDC-ECC'05) Seville, Spain, on December 12-15, 2005. (peer reviewed)

193.

Noh, D. JF Antaki, EK Prem, HS Borovetz and BE Paden. Magnetic levitation design for the PediaFlow™ ventricular assist device. To appear in IEEE/ ASME International Conference on Advanced Intelligent Mechatronics (AIM2005), Monterey, California, July 2005. 24-28.

194.

Gwak, KW, MD Noh, BE Paden and JF Antaki. Fluidic Operational Amplifier for Mock Circulatory Systems – Simulation and Experimental Results, Proc. of the 2005 American Control Conference, (IEEE

JF Antaki, pg 40 of 62

Cat. No. 05CH37668), Portland, OR, June 8-10, 2005. 195.

Chen, S, JF Antaki, MA Simaan, and JR Boston, MA Simaan, Physiological Control of Left Ventricular Assist Devices Based on Gradient of Flow, Proc. of the 2005 American Control Conference, Portland, OR, June 8-10, 2005.

2004 196.

Gwak, KW, BE Paden and JF Antaki. Fluidic Operational Amplifier for Mock Circulatory Systems, Proceedings the 43rd IEEE Conference on Decision and Control, Paradise Island, Bahamas, December 1417, 2004.

197.

Gwak, KW, M Ricci, S Snyder, BE Paden, JR Boston, MA Simaan and JF Antaki. In-Vitro Evaluation of Multi-Objective Hemodynamic Control of a Heart-Assist Pump, Proc. of the 43rd IEEE Conference on Decision and Control, Paradise Island, Bahamas, December 14-17, 2004. 1069-1074.

Non-Refereed Presentations and Conference Proceedings (2004-pres) * - invited presentations denoted by asterisk; (presenter underlined) 1. M… Antaki, JF, Debate: LVADs versus Transplantation (Engineering perspective). ASAIO annual conference, Chicago, IL, June 2015. (no published abstract) 2. Wu, W. T., Aubry, N., Massoudi, M., & Antaki, J. (2015). A Computational and Mathematical Model for Device Induced Thrombosis. Bulletin of the American Physical Society, 60. 3. Yang, F, W-T Wu, JF Antaki Simulation of Thrombus Growth in HeartMate II. ASAIO annual conference, Chicago, IL, June 2015. 4. Martin, B and JF Antaki. Magnetic apheresis device for filtration of malaria-infected red blood cells. ASAIO annual conference, Chicago, IL, June 2015. 5. Jamiolkowski, M, [authors] Real-time analysis of flow-induced thrombus formation within a defined crevice. ASAIO annual conference, Chicago, IL, June 2015. 6. Antaki, JF, multi-scale challenges for simulation of thrombosis in blood-wetted devices, BMES/FDA Frontiers in Medical Device Conference: Innovations in Modeling and Simulation. 2014 7. Antaki, JF, and J Zell, Integrating Improvisational Acting and Inventive Problem Solving in Biomedical Engineering, BMES Annual Conference, San Antonio, TX, Oct 23, 2014. 8. Antaki JF, The Long and Strange Trip from Bench to Bedside: Lessons Learned from the Pediaflow Magnetically Levitated Rotodynamic Blood Pump. BMES Annual Conference, San Antonio, TX, Oct 23, 2014 9. Antaki, JF. Trafficking of Platelets and Red Blood Cells: Theoretical and Experimental Models. World Congress of Biomechanics, Boston, MA, July 6-11. 10. Martin, A, A Gandini and JF Antaki, mPharesis: Dialysis-like device for magnetic filtration of ring stage Plasmodium falciparum infected and Methemoglobin carrying red blood cells. Consortium of Universities for Global Health 2014 (http://2014cughconference.org/) May 10-12, 2014 11. Loghmanpour N, Kanwar M, Bailey S, Benza R, Murali S, Antaki J. Development of a novel predictive model for mortality post continuous flow LVAD implant using Bayesian Networks (BN): the first application to the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database. International Society of Heart and Lung Transplantation Meeting, April 9-13, 2014. (Accepted for oral presentation) 12. Wu, W-T, A Martin, J Kim, J F Antaki, N Aubry, M Massoudi, Theoretical and Numerical Study on a Malaria-Infected Red Blood Cell Separator , ASB 2014 (submitted) 2013 13. Loghmanpour N, Kanwar M, Wang Y, Snyder T, Horstmanshof D, Long J, Gorcsan J, Antaki J, Murali S. A novel, risk stratification model using bayesian networks for continuous-flow left ventricular assist device 90-day survival. J Am Coll Cardiol. 2013;61 14. Loghmanpour N, Kanwar M, Wang Y, Snyder T, Horstmanshof D, Long J, Gorcsan J, Antaki J, Murali S. A novel, risk stratification model using bayesian networks for continuous flow left ventricular assist device 90-day survival. The Journal of Heart and Lung Transplantation. 2013;32:S232 (poster) 15. Hayden, JA, GM Pantalos, JE Burgess, JF Antaki Creating a Hermetically Sealed, Fluid-filled Surgical

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16.

17.

2012 18. 19.

20. 21.

22. 23. 24.

25. 26.

27. 28. 29. 2011. 30.

31.

2010 32.

33.

34.

Enclosure to Perform Procedures in Reduced Gravity Environments, Aerospace Medical Association Annual Meeting (12-16 May 2013, Chicago, IL) Hayden, JA, TA Montidoro, JE Burgess, JF Antaki, GM Pantalos Aqueous Immersion Surgical System for Emergency Neurosurgery Military Health System Research Symposium (12-15 August 2013, Ft. Lauderdale, FL) Pantalos, GM JA Hayden, JE Burgess, JF Antaki, MJ Crigger, TL Kennedy Parabolic Flight Evaluation of a Hermetic Surgical System for Reduced Gravity, NASA Human Research Program Investigator Workshop (2013 Galveston, TX) Antaki, JF – “M-Pharesis: Treatment for Severe Malaria. Presented at ASAIO New Venture Forum. (3 rd place winner.) June 2012 * Antaki JF, Kim J, Singhal A, Burgreen G, Shu F. Aeroelastic analysis of a closing reed of the mouth organ (harmonica), American Society of Acoustics, San Diego, CA Oct 2011 J Acoust Soc Am. 2011 Oct;130(4):2342. (invited) * Antaki, JF, Multiscale Modeling of Thrombosis in Artificial Circulation. Systems Biology Seminar, U Penn, Philadelphia, PA, 11/21/2011 TM Maul, Trumble, D., Wearden, PD, Wu, J., J Verkaik, Snyder, S., M Ricci, Woodard, J., JF Antaki, HS Borovetz, and PediaFlow Consortium. The PediaFlowTM Pediatric Ventricular Assist Device: Finalization of Cannula and Rotor Design. in Gordon Research Conference: Assisted Circulation. Waterville Valley, NH., 2011. Olia SE, Daly AR, Maul TM, Wearden PD, Antaki JF, Borovetz HS, Kameneva MV. "Hemorheological Performance of the 3rd Generation PediaFlow VAD". (poster), ibid. Kim, J, M Massoudi, and J Antaki. On the flow of blood in a sudden expansion channel. The 48th Annual Technical Meeting of Society of Engineering Science, 2011. JF Antaki, TM Maul, Trumble, D.R., J Verkaik, Martin, A., Woodard, J., and HS Borovetz. Development of a Novel Inflow Cannula for the PediaFlowTM Continuous Flow VAD. International Society of Rotary Blood Pumps. Louisville, KY., 2011 JF Antaki, Wu, J., TM Maul, HS Borovetz, and PediaFlow Consortium. Computational Design of the Fourth PediaFlowTM Pediatric Ventricular Assist Device. in ASAIO. Washington D.C, 2011. Daly AR, Olia SE, Nevins JE, Antaki JF, Kameneva MV. Red Blood Cell Mechanical Fragility in the Prediction of Blood Trauma in Blood-Contacting Devices. ASAIO 57th Annual Conference. Washington, DC, June 2011, p80 (Slide Presentation). Kim J, M Massoudi, S Hund, and J Antaki. A Continuum Mechanics Modeling of Two-Component Blood Flow (poster), ibid. Kim J and J Antaki. CFD-Based Shape Optimization of the PediaFlow VAD (poster). ibid. Kim J and J Antaki. CFD-Based Approximation of the PediaFlowTM VAD. FDA/NHLBI/NSF Workshop on Computer Methods for Medical Devices, September 7-9, Silver Spring, MD, USA, Wearden, PD, TM Maul, Wu, J., J Verkaik, Snyder, S., M Ricci, Trumble, D., Woodard, J., MV Kameneva, WR Wagner, JF Antaki, HS Borovetz, and PediaFlow Consortium. The PediaFlow™ Pediatric Ventricular Assist Device. in International Heart and Lung Transplantation Society. San Diego, CA., 2011 Daly A, S Olia, JF Antaki JF, and MV Kameneva. Evaluation of Mechanical Blood Damage as a Function of Shear Stress and Exposure Time in Multiple Shearing Systems. McGowan Institute for Regenerative Medicine 2011 Scientific Retreat, Farmington, PA, March 2011. (Poster Presentation) Maul TM, JF Antaki, E Kocyildirim, AR Daly, CA Johnson, S Olia, J WoolleyR., B Paden, D Paden, M Ricci, Snyder, S., J Verkaik, A Ferriera, G Bearnson, J Kirk, P Khanwilkar, MV Kameneva, WR Wagner, Wearden, PD, HS Borovetz, and the PediaFlow Consortium. Pediatric Mechanical Circulatory Support: Design and Development of the PediaFlowTM Ventricular Assist Device, in World Congress on Biomechanics. Singapore, 2010. Antaki JF, TM Maul, M Ricci, Snyder, S., J Verkaik, Wearden, PD, and PediaFlow Consortium. PediaFlow™ Pre-IDE Application: Finalizing the Design and Testing of the PediaFlow Pediatric VAD in Anticipation of Clinical Trial in 2013. in proceedings ISRBP. Berlin, 2010. Maul TM, E Kocyildirim, AR Daly, CA Johnson, S Olia, D Paden, M Ricci, Snyder, S., J Verkaik, A Ferriera, JF Antaki, G Bearnson, J Kirk, MV Kameneva, WR Wagner, Wearden, PD, HS Borovetz, and

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35. 36. 37.

38. 39. 40. 41.

42.

2009 43.

44.

45.

46.

47.

48. 49. 50. 51. 52.

53.

the PediaFlow Consortium. Pre-Clinical Assessment of the 3rd PediaFlowTM Pediatric Ventricular Assist Device Prototype, in proceedings ASAIO, Baltimore, MD, 2010. Olia S, TM Maul, A Ferriera, JF Antaki, HS Borovetz, and MV Kameneva. Development of a 2nd Gen Data Acquisition Platform for the PediaFlowTM VAD, ibid. Kim J, M Massoudi, S Hund, and J Antaki. A Mixture Theory formulation for Blood Flow. The 47th Annual Technical Meeting of Society of Engineering Science, 2010. Kim J and JF Antaki, Simulation-based automatic optimization of the Pediaflow ventricular assist device. (Podium.) Food and Drug Administration, National Heart Lung and Blood Institute, National Science Foundation Workshop on Computer Methods for Cardiovascular Devices, June 9-11,2010, Rockville, MD. Kim, J, A Gandini, and J Antaki, Numerical Study of Magnetic Field Separator to Remove MalariaInfected Red Blood Cells from the Whole Blood (Poster.) Food and Drug Administration. ibid. Hund, S. & JF Antaki, Analyzing curriculum in Biomedical engineering to improve simulation outcomes. (Podium.) ibid. Hund, S. & JF Antaki, Flow Dependent Variables for Analyzing Medical Devices and Arterial Disease (Poster.) ibid. Wearden, PD, TM Maul, E Kocyildirim, AR Daly, CA Johnson, S Olia, J Woolley, B Paden, D Paden, M Ricci, Snyder, S., J Verkaik, A Ferriera, JF Antaki, G Bearnson, J Kirk, P Khanwilkar, MV Kameneva, WR Wagner, HS Borovetz, and Consortium, P., (2010). In Vivo Evaluation of the PediaFlowTM Pediatric Ventricular Assist Device (VAD), in 26th Annual Children's National Medical Center Symposium ECMO & Advanced Therapies for Respiratory Failure Keystone, CO. Maul, TM, E Kocyildirim, AR Daly, CA Johnson, J WoolleyR., B Paden, D Paden, Snyder, S., J VerkaikE., JF Antaki, G BearnsonB., J Kirk, P Khanwilkar, MV Kameneva, WR Wagner, Wearden, PD, and HS Borovetz. Pre-clinical Assessment of the 3rd PediaFlow™ Pediatric Ventricular Assist Device (VAD) Prototype, in Sixth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion. Boston, MA, 2010 Antaki, JF, P Khanwilkar, M Ricci, S Snyder, J Verkaik, D Paden, TM Maul, PD Wearden, and HS Borovetz. Miniaturization of the PediaFlow™ Pediatric Ventricular Assist Device, in International Society of Rotary Blood Pumps. Singapore, 2009 Maul, TM, PD Wearden, E Kocyildirim, AR Daly, CA Johnson, J Woolley, BE Paden, DB Paden, S Snyder, J Verkaik, JF Antaki, et al. Development of the PediaFlowTM, a Fully Implantable Magnetically Levitated Pediatric Ventricular Assist Device (VAD), in 33rd Annual Meeting of the Midwest Pediatric Cardiology Society. Pittsburgh, PA. 2009. Daly, AR, SE Olia, SG Bengston, TM Maul, PD Wearden, HS Borovetz, JF Antaki, and MV Kameneva. In Vivo Hemorheological Assessment of Biocompatibility of PediaflowTM VAD: Comparison with Sham Implants. Biomedical Engineering Society Annual Scientific Meeting. Pittsburgh, PA, October 2009. Kim J, Hund S, Maul T, Daly A, Borovetz H, Kameneva M, Antaki J. Comparison of hemolysis in the PediaFlowTM VAD between Eulerian method and Lagrangian method by computational fluid dynamics. ibid. Maul, TM, PD Wearden, E Kocyildirim, AR Daly, CA Johnson, J Woolley, S Olia, S Snyder, J Verkaik, D Paden, F Shu, JF Antaki, et al. In Vivo Evaluation of the PediaFlowTM Pediatric Ventricular Assist Device (VAD), ibid. Olia, SE, A Ferreira, TM Maul, JF Antaki, and HS Borovetz, H.S., Development of a Data Logging Platform for the PediaFlow Pediatric Ventricular Assist Device, in BMES: Pittsburgh, PA. ibid. Trumble, DR, JF Antaki, R Benza, and S Murali, Design of Four MEC-based Mechanisms for Musclepowered Circulatory Support, ibid. Zhao R, Daly AR, Borovetz HS, Antaki JF, Kameneva MV. Evaluation of red blood cell deformability in different animal species: application to assessment of biocompatibility of heart-assist devices. ibid. Antaki, JF, Identification and Optimization of Ventricular Recovery. Gordon Research Conference on Assisted Circulation, Waterville, NH, September, 2009. [podium presentation. No proceedings.] Maul, TM, S Snyder, J Verkaik, M Ricci, F Shu, AR Daly, CA Johnson, JR Woolley, MV Kameneva, JF Antaki, et al. Miniaturization of the PediaFlowTM Pediatric VAD, in ASAIO. Dallas, TX. 2009. ASAIO Abstracts, 2009. 55(2): p.158. Kim J and Antaki J. Computational Fluid Dynamic Shape Optimization of the PediaFlowTM VAD. ASAIO Abstracts, 2009. 55(2):p.155.

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54. 55. 56. 57. 58. 59. 60. 61.

62.

63. 2008 64.

65.

66. 67. 68. 69.

70.

71. 72. 2007 73.

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Kim J and J Antaki. Simulation-based Design and Optimization of the PediaFlow VAD. (poster). FDA/NHLBI/NSF Workshop on Computer Methods for Medical Devices, 2009. *Hund S and JF Antaki. Title (Keynote Presentation), ibid. Kim J, S Hund, A Daly, M Kameneva, and J Antaki. Eulerian Method for Numerical Prediction of Hemolysis in PediaFlow VAD. 5th IFAO Proceedings, 2009. 5:p.59. Shu F, J Verkaik, S Snyder, D Paden, J Kim, and J Antaki. Ventricular Assist Device for Toddlers with Hybrid Magnetic-Mechanical Bearings. (poster). ASAIO Abstracts, 2009. 55(2):p.147. Zhao ASAIO Abstracts, 2009 Wang ASAIO Abstracts, 2009 Ferriera ASAIO Abstracts, 2009 Kim, J, SJ Hund, A Daly, MV Kamenva and JF Antaki, Eulerian Method for Numerical Prediction of Hemolysis in PediaFlow VAD, Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, Dallas, TX, May, 2009. Wearden, PD, TM Maul, E Kocyildirim, AR Daly, CA Johnson, J Woolley, B Paden, D Paden, S Snyder, J Verkaik, JF Antaki, F Shu, G Bearnson, J Kirk, P Khanwilkar, M Kameneva, WR Wagner, HS Borovetz, In vivo Evaluation of the PediaFlow™ Pediatric Ventricular Assist Device. ibid. Finol, E, …. Antaki JF…, validation of abdominal aortic aneurysm dynamics: a comparative analysis of piv, cfd, and fsi, 2009 Summer Bioengineering Conference, June 17-21, Lake Tahoe, CA. Hund SJ, MV Kameneva MV, JF Antaki JF. A new approach to modeling blood viscosity. The 13th International Congress of Biorheology and 6th International Conference on Clinical Hemorheology, Pennsylvania State University, State College, July 9-13, 2008. Abstract published in Biorheology 45 (12):83-83, 2008. J.N. Marhefka, S.S. Velankar, R. Zhao, Z. Wu, J.F. Antaki and M.V. Kameneva Effects of blood-soluble drag-reducing polymers on macro- and microhemodynamics: Potential clinical applications International Conference on Clinical Hemorheology. ibid. *J.F. Antaki. Computational indices for prediction of flow-induced blood trauma. ibid. Zhao R, M Massoudi, SJ Hund, M.V. Kameneva and J.F. Antaki Experimental and theoretical investigation of blood microflow dynamics associated with blood contacting devices. ibid Simaan, M. and JF Antaki, Progress with extremum-seeking feedback controller for a rotary blood pump, (Moderated Poster Session), 54th ASAIO Annual Conference, San Francisco, CA, June 2008. Wearden, P.D., Johnson, C.A., Woolley, J.R., Antaki, J.F., Arnold, D., Bachman, T.N., Bearnson, G.B., Daly, A.R., Drummond, A., Kameneva, M.V., Keller, B.B., Khanwilkar, P., Kirk, J., Kormos, R.L., Kouretas, P.C., Maul, T.M., Morell, V.O., Paden, B.E., Paden, D.B., Ricci, M., Shu, F., Snyder, S., Vandenberghe, S., Verkaik, J., Wagner, W.R., Webber, S.A., Wu, J., Ye, S.H., and Borovetz, H.S. (2008). In Vitro and In Vivo Testing of the PediaFlow™ Pediatric Ventricular Assist Device, ibid. Zhao R, J Marhefka, E Skicki, JF Antaki, and MV Kameneva. Drag Reducing Polymer Eliminates Platelet Margination in Microchannel. The 54th Annual Conference of American Society for Artificial Internal Organs, San Francisco, CA, June 2008. Abstract published in ASAIO Journal. 54(2):23A, 2008. Arielle D, Bradley Keller, James Antaki and Harvey Borovetz, “Anatomic Database for Insertion of VADs in Infants and Young Children,” (poster), ibid. Arielle D, Josiah Verkaik, Stijn Vandenberghe, Timothy Maul, Pietro Bajona, Peter Wearden and James Antaki , “ In-Vivo Evaluation of Conformal Pediatric Ventricular Cannula,” (Poster), ibid. Bhama, JK, T Bachman, HS Borovetz, RL Kormos, and JF Antaki, Visualization of ventricular “suck down” during mechanical circulatory support, Annals of thoracic surgery images in cardiothoracic surgery, 2007. Wooley, J, J Antaki, D Arnold, T Bachman, G Bearnson, A Drummond, J Gardiner, M Kameneva, B Keller, P Khanwilkar, J Kirk, P Kouretas, C Johnson, M Oberdier, B Paden, D Paden, M Ricci, F Shu, S Snyder, S Vandenberghe, J Verkaik, W Wagner, P Wearden, S Webber, J Wu, S-H Ye and H Borovetz, Development and initial in vivo evaluation of the pediaflow™ventricular assist device. Gordon Research Conference on Assisted Circulation, Big Sky, MT, August 26, 2007. [poster presented. No proceedings.] Vandenberghe S, J Antaki, R Kormos, and J Gorcsan, Identifying and facilitating ventricular recovery on mechanical assist. Gordon Research Conference on Assisted Circulation, Big Sky, MT, August 26, 2007. [poster presented. No proceedings.]

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2006 86.

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Zhao, R, J Marhefka, M Kameneva, and J Antaki, The effect of red cell dynamics on platelet spatial distribution in sudden expansion. ASME 2007 Summer Bioengineering Conference (SBC2007), June 2024, Keystone Resort & Conference Center, Keystone, Colorado, 2007. Wu, J, JF Antaki, F Shu, S Vandenberghe, D Paden, BE Paden, and HS Borovetz. Computational study of hemodynamic characteristics of magnetically levitated Pediaflow™ VAD, In Proceedings ASAIO 53rd Annual Conference, Chicago, IL, June 7-9, ASAIO Journal., March/April 2007. Hund, SJ and JF Antaki, An extended shear activation model for platelet-mediated thrombosis. In Proceedings ASAIO 53rd Annual Conference, Chicago, IL, June 7-9, ASAIO Journal., March/April 2007. Hund, SJ and JF Antaki, A multi-activation state model for chemical induced platelet aggregation. In Proceedings ASAIO 53rd Annual Conference, Chicago, IL, June 7-9, ASAIO Journal., March/April 2007. PD Wearden, JF Antaki, DK Arnold, T Bachman, SF Badylak, G Bearnson, JR Boston, A Drummond, J Gardiner, CA Johnson, MV Kameneva, BB Keller, P Khanwilkar, J Kirk, RL Kormos, C-M Li, JW Long, T Maher, P Miller, VO Morell, D Paden, B Paden, M Ricci, F Shu, M Simaan, S Snyder, TA Snyder, J Verkaik, WR Wagner, SA Webber, JR Woolley, J Wu, and HS Borovetz. Development of the Pediaflow VAD for infants and small children. In Proceedings ASAIO 53rd Annual Conference, Chicago, IL, June 79, ASAIO Journal, March/April 2007. Bachman, T, J Bhama, J Verkaik, H Borovetz, R Kormos, and J Antaki. In-situ visualization of ventricular suction: effect of cannula design and placement. ibid. Snyder T, Woolley J, Marascalco P, Antaki J, Wagner W, Kameneva M. Validity of Normalized Index of Hemolysis in Pediatric Mechanical Circulatory Assist Devices and Application to Hemolysis Testing of Five Pediatric Blood Pumps. ibid. Antaki, JF, et al. Development of the PediaFlow™ Ventricular Assist device for Infants and Small Children, Third International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, Hershey, PA – May 19-21, 2007 (slide.) Antaki, JF and F Shu, PulsarTM blood pump optimized configuration for enhanced performance, 27 th Annual Conference on Dialysis, February 18-20, Denver, CO, 2007 Drummond, A, T Bachman, B Newman, B Keller, and J Antaki, “Non-Invasive Anatomical Compatibility Study for a Pediatric Ventricular Assist Device,” Paper presented at Medicine Meets Virtual Reality Conference. February 2007. Drummond, A, T Bachman, B Keller, and J Antaki, “Three Dimensional Virtual Anatomic Fit Study for an Implantable Pediatric Ventricular Assist Device,” Paper presented at International Conference on Computational Science. May 2006. Witherell, P., S. Krishnamurty, I. Grosse and J. Antaki, Analysis and Optimization of PVAD Impeller. 2006 Summer Bioengineering Conference, 2006. Ricci, M, S Snyder, G Bearnson, Y-C Yu, and JF Antaki. Sensorless multiobjective physiologic control and suction avoidance for a rotary VAD. ASAIO Cardiac Abstracts, ASAIO Journal. 52(2):47A, March/April 2006. Antaki, JF, et al. Development of the PediaFlow™ Ventricular Assist device for Infants and Small Children, ASAIO Cardiac Abstracts, ASAIO Journal. 52(2), March/April 2006. Wu, J, JF Antaki, J Gardiner, D Paden, BE Paden, and H Borovetz, CFD-based optimization of magnetically levitated pediaflow ventricular assist device. ASAIO Cardiac Abstracts, ASAIO Journal. 52(2):43A, March/April 2006. Kameneva MV, P Marascalco, T Snyder, and JF Antaki. Validity of normalized index of hemolysis in pediatric mechanical circulatory assist devices. The 52nd Annual Conference of American Society for Artificial Internal Organs, Chicago, IL, June 2006 (ASAIO Journal. 52(2):41A, 2006). Antaki J, Arnold D, Bachman T, Bearnson G5, Borovetz H, Gardiner J, Donachy Jr. J, Drummond A, Johnson C, Kameneva M, Keller B, Kirk J, Kormos R, Maher T, Morell V, Paden B, Paden D, Ricci M, Shu F, Snyder T, Snyder S, Vandenberghe S, Wagner W, Verkaik J, Wearden P, Weber S, Woolley J, WU J, Pathway to the First Generation PediaflowTM VAD, In Proceedings, International Society of Rotary Blood Pumps, Leuven, Belgium, August 30, 2006. *Antaki, JF, The Biomedical Engineer-Entrepreneur of the Future. Clarkson University, Jan 30, 2006 (Engineering Seminar) Kim, N-J, SS Lee, JA Lee, K Sun, JF Antaki, KH Ahn and SJ Lee, Effect of arterial stiffness on red blood

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cell deformability, 2005 BMES Annual Fall Meeting, October 2005. (Poster.) *Antaki, JF, Hemodynamic Feedback Control of (Turbodynamic) Circulatory Support, Gordon Research Conference on Circulatory Support, Big Sky, MT, Sept 2005. Lee, SS, NJ Kim, JF Antaki, KH Ahn, SJ Lee. Red blood cell relaxation time measured by shape recovery after cessation of flow. to appear in: The 12th International Congress of Biorheology (12thICB) and 5th International Conference on Clinical Hemorheology (5thICC), February 2005. Lee, SS, KH Ahn, SJ Lee, K Sun, JF Antaki, MV Kameneva, I Dobbe, and MR Hardeman, The effect of magnitude and duration of shear exposure on the characteristics of red blood cells. to appear in Proceedings, Society of Rheology Conference, 2005, Session: Biological systems *Antaki JF, Advances in Quantitative Biomedical Models. American Society of Artificial Internal Organs, Washington DC, June 10, 2005. Uber, B, J. Teuteberg, R. Kormos, J. Antaki, H. Tsukui, M. Simon, S. Winowich, E. Stanford, S. Weaver, Y. Toyoda. Decision aid for evaluation of risk/benefit of RVAD for patients receiving LVAD. The Journal of Heart and Lung Transplantation, Volume 25, Issue 2, Pages 96-96, 2005. Antaki, JF, J Wu, TA Snyder, WR Wagner, HS Borovetz, BE Paden, and C Diao, CFD analysis of blade tip clearances on hemodynamic performance and blood damage in a miniature pediatric blood pump. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2): 44A. *Antaki, JF, C Diao, J Wu, HS Borovetz, W Wagner and TA Snyder, Microscopic flow visualization of red blood cell trajectory in the blade tip and back clearance of a mini blood pump. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2): 6A. [Special Abstract Presentation session: Elected one of five “Top Ranked Abstract Overall.”] Wu, J, JF Antaki, HS Borovetz, GB Bearnson, J R Boston, C Diao, J A Hawkins, J Gardiner,G Jacobs, MV Kameneva, BB Keller, PK Khanwilkar, J Kirk, RL Kormos, V Morell, JW Long, CM Li, S Miles, E Prem, BE Paden, D Paden, T Snyder, H Tsukui, S Vandeberghe, WR Wagner, SA Webber, RE Shaddy and MA Simaan, Progress with pediaflow maglev pump for infants and small children: Form to function. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2). Santelices, L, Druzdzel, R Schaub, B Uber, RL Kormos, and JFAntaki, Clinical decision support system for optimal VAD weaning. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2) Wu, J, JF Antaki, TA Snyder, WR Wagner, HS Borovetz, BE Paden, and C Diao. Elimination of reversal flow in back clearance gaps of a miniature pediatric centrifugal blood pump by CFD, Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2) Vandenberghe, S,, P Segers, J Antaki, R Shihab, and P Verdonck, In vitro evaluation of pulsatile use of the new Medos DeltaStream pump, Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2) Antaki, JF, J Wu, TA Snyder, WR Wagner, HS Borovetz, BE Paden and C Diao. CFD analysis of blade tip clearances on hemodynamic performance and blood damage in a miniature pediatric blood pump. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2): 44A. Wu, J, JF Antaki, HS Borovetz, GB Bearnson, JR Boston, C Diao, JA Hawkins, J Gardiner, G Jacobs, MV Kameneva, BB Keller, PK Khanwilkar, J Kirk, RL Kormos, V Morell, JW Long, CM Li, S Miles, EK Prem, BE Paden, DB Paden, T Snyder, H Tsukui, S Vandeberghe, WR Wagner, SA Webber, RE Shaddy and MA Simaan. Progress with PediaFlowTM maglev pump for infants and small children: Form to function. Proceedings of American Society of Artificial Internal Organs, Washington DC, June 2005: ASAIO J 51(2). Ferreira, A, DG Galati, MA Simaan, JF Antaki, and JR Boston, "A Dynamical State Space Representation of the Left Ventricle of the Heart Coupled with an Assist Rotary Pump" ASME Conference 2005. Snyder, S., B Paden, J Antaki, and HS Borovetz, Thermodynamic Analysis of PediaFlow Pediatric Ventricular Assist Device, First International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, Hershey, PA – May 19-21, 2005 Lee, S. S., Kim, N. J., Sun, K., Dobbe, J.G., Hardeman, M. R, Antaki, J. F., Ahn, K. H., and Lee, S. J., 2005, “Arterial stiffness effect on the deformability of red blood cells,” Proceedings, 2005 ASME Summer Bioengineering Conference, Vail Cascade Resort & Spa, Vail, CO, June 22-26.

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Hund, S, and J Antaki, Improved methodologies for the e-design of medical devices . 2005 International Conference on e-Design, May 14, 2005, Omni Hotel at CNN Center, Atlanta, GA

CONFERENCE PROCEEDINGS AND PRESENTATIONS (pre-2004, unsorted) (Invited presentations indicated by asterisk *.) 112. Chen, S, M Simaan, JR Boston, JF Antaki, A physiological control of left ventricular assist devices based on gradient of pump flow. Proceedings The 43rd IEEE Conference on Decision and Control December 1417, 2004 Atlantis, Paradise Island, Bahama. 113. Gwak, KW, BE Paden, and JF Antaki, Fluidic Operational Amplifier for Mock Circulatory Systems, Proceedings The 43rd IEEE Conference on Decision and Control December 14-17, 2004 Atlantis, Paradise Island, Bahama. 114. Gwak, K-W, M. Ricci, S. Snyder, B. E. Paden, J. R. Boston, M. A. Simaan, and J.F. Antaki, In-Vitro Evaluation of Multi-Objective Hemodynamic Control of a Heart-Assist Pump, Proc. of the 43rd IEEE Conference on Decision and Control, Paradise Island, Bahamas, Dec. 14-17, 2004, pp. 1069-1074. 115. Antaki, JF. “Design of Pediatric Heart-Assist Devices: Hemorheological Challenges & Opportunities,” Drexel University, Department of Biomedical Engineering, Philadelphia, PA. May 20, 2005. 116. Antaki J, KW Gwak, S Chen, M Ricci, C Chen, F Colacino, S Snyder, A Feriera, Y-C Yu, JR Boston, BE Paden, M Simaan, and G Bearnson. Optimal feedback control of turbodynamic VAD: Efficacy of multiobjective tracking algorithms. Proceedings International Society of Rotary Blood Pumps, Cleveland, OH, October 2004. 117. Diao C, L Zhu and JF Antaki. An experimental study on temperature and blood flow response in rat brain during SBC and rewarming. Proceedings BMES Annual Meeting, October 2004. 118. Zhao R, JF Antaki, Z Wu, C Diao, and MV Kameneva. Red Blood Cell Response to Supra-physiologic Shear Stress in Micro-Channels. To appear in Proceedings BMES Annual Meeting, October 2004. 119. Borovetz, HS, JF Antaki, G Bearnson, R Boston1, C Chen, S Gandhi, J Hawkins, G Jacobs, MV Kameneva, B Keller, P Khanwilkar, R Kormos, CM Li, J Long, S Miles, BEB Paden, D Paden, R Shaddy, M Simaan, T Snyder, WR Wagner, S Webber, J Wells, J Wu, L Yount. Development of a Ventricular Assist Device for Infants and Small Children. Gordon Research Conference on Assisted Circulation, Big Sky, MT, September 14-19, 2004. [poster presented. No proceedings.] 120. Snyder TA, JF Antaki, G Bearnson, R Boston, C Chen, S Gandhi, J Hawkins, G Jacobs, MV Kameneva, B Keller, P Khanwilkar, RL Kormos, CM Li, J Long, S Miles, BE Paden, DB Paden, R Shaddy, M Simaan, WR Wagner, S Webber, J Wells, J Wu and L Yount. Development of ventricular assist devices for infants and small children. American Society of Artificial Internal Organs, Washington DC, June 2004. 121. Khanwilkar PS, JW Long, JF Antaki, BE Paden, S Miles, GB Jacobs, C King, C Chen and GB Bearnson. Evolution of implantable, magnetically levitated HeartQuest™ VAD for destination therapy. To appear in American Society of Artificial Internal Organs, Washington DC, June 2004. 122. Gwak, K, M Ricci, JF Antaki and BE Paden. Responsiveness of hemodynamic controller based on venous return index and harmonic index to time-varying metabolic demand on mock circulatory loop. To appear in American Society of Artificial Internal Organs, Washington DC, June 2004. 123. Gwak, K-W, MD Noh, BE Paden, and JF Antaki, Fluidic Operational Amplifier for Mock Circulatory Systems – Simulation and Experimental Results, Proc. of the 2005 American Control Conference, (IEEE Cat. No. 05CH37668), Portland, OR, June 8-10, 2005. 124. *Antaki, J. Rational Prescriptive Design of Pediatric VADs. (Invited.), First International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, Hershey, PA – May 19-21, 2005 125. *Antaki, JF, “Pediatric Blood Pumps of Pittsburgh.” International Society of Rotary Blood Pumps, Cleveland, OH, October 2004. [Invited] 126. Antaki, J, K-W Gwak, S Chen, M Ricci, C Chen, F Colacino, S Snyder, A Feriera, Y-C Yu, JR Boston, B Paden, M Simaan, and G Bearnson, Optimal feedback control of turbodynamic VAD: Efficacy of multiobjective tracking algorithms. Proceedings International Society of Rotary Blood Pumps, Cleveland, OH, October 2004. 127. Bullister, Edward, H Reul, T Kink, and JF Antaki, CFD modeling of blood damage in rotary pumps. Proceedings International Society of Rotary Blood Pumps, Cleveland, OH, October 2004. 128. *Antaki, JF, G, Blelloch, O Ghattas, S Green, M Kameneva, I Malcevic, G Miller, G Turkiyya, N

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Walkington, Z Wu, Optimal Design of Blood Flow within Artificial Hearts Devices on Terascale Supercomputers, 41st Annual SES Technical Meeting, Lincoln, Nebraska Oct 10, 2004. [Invited] Diao C, L Zhu and JF Antaki, An experimental study on temperature and blood flow response in rat brain during SBC and rewarming. To appear in; Proceedings BMES Annual Meeting, Oct. 2004. Zhao, R, JF Antaki, Z Wu, C Diao, and MV Kameneva, Red Blood Cell Response to Supra-physiologic Shear Stress in Micro-Channels, To appear in; Proceedings BMES Annual Meeting, Oct. 2004. Hund, SJ, JF Antaki, O Ghattas, et al… Hemodynamic Optimization of a Ventricular Cannula: Evaluation of Objective Functions, In; Proceedings BMES Annual Meeting, Oct. 2004. Naik T and JF Antaki, Fluid-structure interactions of ventricular cannulation. To appear in; Proceedings BMES Annual Meeting, Oct. 2004. Antaki JF, Future Opportunities for Innovation of Artificial Organs, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Snyder TA, JF Antaki, G Bearnson, R Boston, C Chen, S Gandhi, J Hawkins, G Jacobs, MV Kameneva, B Keller, P Khanwilkar, RL Kormos, CM Li, J Long, S Miles, B Paden, D Paden, R Shaddy, M Simaan, W Wagner, S Webber, J Wells, J Wu, and L Yount, Development of ventricular assist devices for infants and small children, American Society of Artificial Internal Organs, Washington DC, June 2004. Pagani I, A Quist, H Lin, S Green, GM Turkiyyah, J Antaki, and R Lal, Precision mapping of erythrocyte trauma by atomic force microscopy, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Khanwilkar PS, JW Long, JF Antaki, B Paden, S Miles, GB Jacobs, C King, C Chen and GB Bearnson, Evolution of implantable, magnetically levitated heartquest™ vad for destination therapy, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Hund, S, JF Antaki, O Ghattas, Optimal flow path design of ventricular cannula. Optimal Flow Path Design of a Ventricular Cannula, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Naik, T and JF Antaki, Numerical simulation of ventricular cannulation, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. [Zhao, R, Z Wu, M Kameneva, and JF Antaki.] Investigation of micro-scale blood flow behavior and shear-induced blood damage by cell tracking Velocimetry. To appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Gwak, K, M Ricci, JF Antaki, and B Paden. Responsiveness of hemodynamic controller based on venous return index and harmonic index to time-varying metabolic demand on mock circulatory loop, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Tabaksblat, M, AZ Hunsberger, M Simaan, R Kormos, J Gorcsan, S Shroff, and JF Antaki, Development of computer simulator for left ventricular recovery, to appear in: American Society of Artificial Internal Organs, Washington DC, June 2004. Santelices LC, JF Antaki, MA Dew, MB Holm, RL Kormos, MA Mathier, and MA Simaan, Mobile decision support system for treatment of LVAD patients, In Proceedings: American Society of Artificial Internal Organs, Washington DC, June 2004.. Borovetz, H, J Antaki, G Bearnson, R Boston1, C Chen, S Gandhi, J Hawkins, G Jacobs, M Kameneva1, B Keller, P Khanwilkar, R Kormos, C-M Li, J Long, S Miles, B Paden, D Paden, R Shaddy, M Simaan, T Snyder, W Wagner, S Webber, J Wells, J Wu, L Yount, Development of a Ventricular Assist Device for Infants and Small Children. Gordon Research Conference on Assisted Circulation, Big Sky, MT, 9/1419/2004 [poster presented. No proceedings.] Antaki JF, GB Bearnson, HS Borovetz, JR Boston, C Chen, SK Gandhi, JA Hawkins, G Jacobs, MV Kameneva, BB Keller, P Khanwilkar, RL Kormos, C-M Li, KN Litwak, JW Long, S Miles, BE Paden, D Paden, RE Shaddy, MA Simaan, TA Snyder, WR Wagner, SA Webber, EJ Wells, J Wu, Z Wu, LJ Yount, Miniature maglev centrifugal pump for infants and small children: initial progress. In Proceedings International Society Rotary Blood Pumps, Aachen, Germany, August 2003. *Antaki JF, Microstructural modeling of hemorheology and hemolysis, Response of Blood to Mechanical Circulatory Support, First International Conference on Medical Implants, Bethesda, MD, July 25, 2003. =Invited= Bearnson, G, G Jacobs, J Antaki, and J Long, Flow Estimation and Antisuction Control in HeartQuest™ LVAD In: Proceedings ASAIO, Washington, DC, June 2003, pp 223. Miles, S, et al. HeartQuest™ LVAD optimized clinical design. In: Proceedings ASAIO, Washington, DC,

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June 2003, pp 186. *Antaki JF, “Challenges of Control of Rotary Blood Pumps” In: Proceedings ASAIO, Washington, DC, June 2003 = Invited = Antaki JF, JC Ludlow, GW Burgreen, J Wu, Z Wu and SD Miles, Low profile inlet for centrifugal blood pump. In: Proceedings ASAIO, Washington, DC, June 2003, p 154. Paden B , J Antaki , and N Groom Mechatronic Design and Optimization of an Artificial Heart, 2nd IFAC Conference on Mechatronic Systems, December 9-11, 2002, Berkeley, California, USA Miles S, G Jacobs, J Ludlow, T Nieman, B Vance, G Bearnson, J Long, B Paden C Chen, J Antaki. HeartQuest VAD clinical design performance. In Proceedings, International Society of Rotary Blood Pumps, Osaka, Japan, 8/2002. Bearnson, G, G Jacobs, J Antaki, J Long, Flow estimation and antisuction Control in HeartQuest LVAD, In Proceedings, International Society of Rotary Blood Pumps, Osaka, Japan, 8/2002. Antaki JF, JR Boston, M Simaan, Z Wu. Current control strategies for turbodynamic blood pumps. Proceedings: Second Joint EMBS-BMES Conference, Houston, TX, 10/23-26/2002. Sorensen EN, GW Burgreen, WR Wagner, JF Antaki. Simulation of platelet deposition in disturbed flow. Proceedings: Second Joint EMBS-BMES Conference, Houston, TX, 10/23-26/2002. Chen C, B Paden, J Antaki, J Ludlow, G Bearnson. Optimal design of permanent magnet bearings with application to the HeartQuest ventricular assist device design. Trans. ISMB, 6/2002. Chen C, B Paden, J Antaki, J Ludlow, G Bearnson. Optimal design of permanent magnet bearings with application to the HeartQuest ventricular assist device. Proceedings: International symposium on magnetic bearings, Japan, 8/26-28/2002. Antaki JF, HT Bahnson, GW Burgreen. Acoustic Coupling between Oral Tract and Diatonic Harmonica: Recent Observations. Proceedings: American Society of Acoustics, Pittsburgh, PA, 6/2002. Chen C, B Paden, J Antaki, J Ludlow, G Bearnson. Optimal design of the HeartQuest magnetic suspension. Proceedings: ASAIO, 6/2002. Antaki JF, Z Wu, D Liu, M Simaan, JR Boston. A multi-objective control algorithm for turbodynamic blood pumps. Proceedings: 9th Congress of the International Society for Rotary Blood Pumps, Seattle, WA, A6, 8/17-20/2001. Chen C, B Paden, J Antaki, J Ludlow, D Paden, R Crowson, P Diegel, G Bearnson, and D Olsen. A magnetic suspension theory and its application to the HeartQuest maglev VAD. Proceedings: 9th Congress of the International Society for Rotary Blood Pumps, Seattle, WA, 8/17-20/ 2001 Antaki JF, Y Liu, Z Wu, P Diegel, J Long. Cannula design can reduce regurgitant flow during VAD stoppage: When a check valve is not a check valve. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Gottlieb R, J Antaki, Z Wu. Visualization of wall shear stress in blood wetted artificial organs using liquid crystal shear sensor. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Snyder TA, J Wu, JF Antaki, GW Burgreen, WR Wagner. In-vitro investigation of shear-induced platelet activation in axial flow VADs. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Long JW, PD Diegel, JF Antaki, GB Bearnson, D Paden, PE Allaire, DB Olsen. Preliminary in-vivo experience with the new HeartQuest MagLev LVAD. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Chen C, JF Antaki, J Ludlow, B Paden, J Long. Design optimization of the HeartQuest MagLev LVAD. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Lemmire P, S Day, N Landrot, JC McDaniel, HG Wood, P Allaire, J Antaki. A quantitative oil streak method for measuring the flow patterns and the wall shear stresses in a blood pump. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. Landrot N, H Wood, J Antaki, P Allaire, JC McDaniel. CFD Analysis of the HeartQuest LVAD. Proceedings: ASAIO 2001, New York, NY, 6/7-9/2001. *Yu Y-C, JR Boston, M Simaan, JF Antaki. Minimally invasive identification of ventricular recovery index for weaning patient from artificial heart support. In Proceedings: Control and Decision Conf., Sydney, Australia, 1799-1803, 12/12-15/2000. =Invited= D Liu, JR Boston, M Simaan, and JF Antaki. Multi-objective optimization for ventricular assist devices. In Proceedings: Control and Decision Conf., Sydney, Australia, 1799-1803, 12/12-15/2000. Antaki JF, GE Blelloch, O Ghattas, I Malcevic, GL Miller, NJ Walkington. A Parallel Dynamic-Mesh Lagrangian Method for Simulation of Flows with Dynamic Interfaces. Proceedings: SC 2000, Dallas, TX,

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11/4-10/2000. Burgreen, GW, JF Antaki, J Wu, and JA Holmes. CFD-based design optimization of the UoP streamliner rotary blood pump. In Proceedings: 2000 Annual Fall Meeting of the Biomedical Engineering Society, Oct 12-14, Washington, WA. Annals of Biomedical Engineering 28(SUPPL. 1) S-1, 2000. *Antaki JF, GW Burgreen, ZJ Wu, D Borzelleca, MV Kameneva, JA Holmes, P Litwak, K Litwak, M Watach, BE Paden, T Dragnes, NJ Groom, BP Griffith. Development progress of the University of Pittsburgh Streamliner: A mixed flow blood pump with magnetic bearings. In Proceedings: ASAIO 2000, New York, NY, June 7-9, ASAIO Journal, 46(2): 194, 2000. =Invited= Butler K, D Thomas, L Taylor, T Petersen, V Poirier, F Parsaie, RL Kormos, HS Borovetz, P Litwak, K Litwak, M Kameneva, J Wu, J Antaki, M Watach. The Heartmate-II axial flow LVAS: journey toward clinical trial. In Proceedings: ASAIO 2000, New York, NY, June 7-9, ASAIO Journal, 46(2): 195, 2000. Kameneva, MV, J Antaki, RD Schaub, MJ Watach, WR Wagner, P Litwalk, HS Borovetz, and BP Griffith. Development and evaluation of a new method of vascular graft denucleation. In Proceedings: ASAIO 2000, New York, NY, June 7-9, ASAIO Journal, 46(2): 180, 2000. Boston JR, JF Antaki, MA Simaan. Hierarchical control for artificial hearts. Proceedings: IEEE International Symposium on Bio-Informatics and Biomedical Engineering, 376-383, Washington, DC, 11/5-8/2000. Baloa L, JF Antaki. Suction detection in rotary ventricular assist devices. Proceedings: Chicago 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, IL, 7/23-28/2000. Liu D, JR Boston, M Simaan, and JF Antaki. Multi-objective optimization for ventricular assist devices. Proceedings: Chicago 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, IL, 7/23-28/2000. Baloa L, L Dehou, JR Boston, MA Simaan and JF Antaki. Control of rotary heart assist devices. In Proceedings: 2000 American Control Conference, Chicago, IL, June 28-30, vol. 5, pp. 2982-2986, 2000. Paden, B, J Ghosh, and J Antaki. Control system architecture for mechanical cardiac assist devices. In Proceedings: 2000 American Control Conference, Chicago, IL, June 28-30. vol. 5, pp. 3478-3482, 2000. Boston, JR, M Simaan, JF Antaki, and Y-C Yu. Control issues in rotary heart assist devices. In Proceedings: 2000 American Control Conference, Chicago, IL, June 28-30. vol. 5, pp. 3473-3477, 2000. Boston, JR, L Baloa, D Liu, M Simaan, S Choi, and J Antaki. Combination of data approaches to heuristic control and fault detection. In Proceedings: The 2000 IEEE International Conference on Control Applications, Anchorage, vol. 1, pp. 98-103, 2000. Thibeault, NM; R Smith, B Paden, and J Antaki. Achievable Robustness Comparison of Position Sensed and Self-Sensing Magnetic Bearing Systems. In: 5th International symposium Magnetic suspension technology, December 1999, Santa Barbara, CA. Groom, NJ and CP Britcher (eds.) NASA CONFERENCE PUBLICATION NO 210291, pp 563-574. Paden, B, J Antaki and N Groom, N. Animal Trials of a Magnetically Levitated Left-Ventricular Assist Device In: 5th International symposium Magnetic suspension technology, December 1999, Santa Barbara, CA. Groom, NJ and Britcher, CP (eds.) NASA CONFERENCE PUBLICATION NO 210291, pp 251-258. Antaki JF, HT Bahnson and QC Beery. Physics, phonetics, and physiology of the diatonic harmonica. 138th Meeting of the Acoustical Society of America, 1-5 Nov 1999 Columbus, OH, 1999. Liu D, JR Boston, H-H Lin, JF Antaki, MA Simaan, J Wu. Monitoring development of suction in an LVAD. Proceedings: BMES-EMBS 1st Joint Conference, Atlanta, GA, 10/13-16/1999. Baloa LA, JR Boston, JF Antaki. Response of elastance-based control due to changes in afterload and contractility. Proceedings: BMES-EMBS 1st Joint Conf., p. 241, Atlanta, GA, 10/13-16/1999. Kameneva MV, GW Burgreen, K Kono, JF Antaki, B Repko, M Umezu. On the mechanical blood trauma: Effect of turbulence. Proceedings: IEEE 1999 Joint BMES/EMBS Conference, Atlanta, GA, 10/1316/1999. Thomas D, JF Antaki, J Wu, JR Boston, L Baloa, S Choi, K Litwak, P Litwak, M Watach, L Gordon, KC Butler. Sensorless closed loop speed control for rotary blood pumps. Proceedings: International Rotary Blood Pump Conference, Tokyo, Japan, 1999. Tomioka J, H Hiramatsu, A Ohshima, T Mori, K Yamazaki, JF Antaki, MV Kameneva, T Akimoto, H Koyanagi. Integrity of a mechanical seal having a recirculating cooling water system for an implantable centrifugal blood pump. Artificial Organs, 23:681, 1999. Yu Y-C, JR Boston, MA Simaan, JF Antaki. Minimally Invasive Estimation of Systemic Vascular Parameters. 14th World Congress of the International Federation of Automatic Control (IFAC), vol. I:85-

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90, 1999. Antaki JF, J Wu, JR Boston, L Baloa, S Choi, K Litwak, P Litwak, M Watach, L McCue, D Thomas, KC Butler. In continued search of... control for turbodynamic blood pumps. Proceedings: 45 th Annual Conference ASAIO, San Diego, CA, 6/3-5/1999. Thomas D, K Butler, L Taylor, P LeBlanc, T Rintoul, T Petersen, B Griffith, R Kormos, H Borovetz, P Litwak, K Litwak, M Kameneva, S Choi, G Burgreen, J Wu, J Antaki. The Nimbus-University of Pittsburgh Axial Flow Left Ventricular Assist System. Proceedings: 45 th Annual Conference ASAIO, San Diego, CA, 6/3-5/1999. Akimoto T, K Yamazaki, P Litwak, O Tagusari, T Mori, JF Antaki, M Kameneva, M Watach, M Umezu, J Tomioka, RL Kormos, H Koyanagi, BP Griffith. The centrifugal blood pump works at the lower pump differential pressure even under hypertension. Proceedings: 45 th Annual Conference ASAIO, San Diego, CA, 6/3-5/1999. Akimoto T, K Yamazaki, P Litwak, KN Litwak, O Tagusari, T Mori, JF Antaki, MV Kameneva, MJ Watach, M Umezu, J Tomioka, RL Kormos, K Hitoshi, BP Griffith. Rotary blood pump flow spontaneously increases during exercise under constant pump speed: Results of a chronic study. Artificial Organs, 23:797-801, 1999. Yu Y-C, JR Boston, MA Simaan, JF Antaki. Sensitivity analysis of cardiovascular models for minimally invasive estimation of systemic vascular parameters. Proceedings: American Control Conference, 33923396, San Diego, CA, 6/2-4/1999. Sorensen EN, GW Burgreen, WR Wagner, JF Antaki. Computational analysis of platelet deposition and thrombus grown on biomaterials. Proceedings: ASME 1999 Summer Bioengineering Conference, Big Sky, MT, 6/16-20/1999. Sorensen EN, GW Burgreen, WR Wagner, JF Antaki. Computational simulation of platelet-mediated thrombogenesis on biomaterials. Proceedings: Society for Biomaterials 1999 Annual Meeting, Providence, RI, 4/28-5/2/1999. *Antaki JF, BE Paden, GW Burgreen, JA Holmes, Z Wu, DC Borzelleca, BP Griffith. The “Streamliner” a magnetically levitated mixed flow blood pump with computer optimized fluid dynamics. Proceedings: 27 h Congress of the Japanese Society for Artificial Hearts and Assisted Circulation, Hakone, Japan, 2/2627/1999. =Invited presentation= Antaki J, G Blelloch, G Burgreen, O Ghattas, I Malcevic, G Miller, G Turkiyyah, N Walkington. Towards microstructural blood flow modeling on petaflops computers. 2nd Conference on Enabling Technologies for Peta(fl)ops Computing. Santa Barbara, CA, Sponsors: DARPA, NASA, NSF, DOE, NSA.1, 2/15– 19/1999. *Antaki JF, O Ghattas, et al. Teraflops computer simulation of blood flow for artificial organ design. Biomedical Engineering Society, L Golding, chairman, 10/1998. =Invited Presentation= *Antaki JF, ZJ Wu, GW Burgreen, EN Sorensen, JA Holmes, BP Griffith. Fluid dynamic phenomena within a magnetically levitated mixed flow blood pump. Proceedings: Third World Congress Bioengineering, Sapporo, Japan, 8/2-8/1998. =Invited Presentation (but unable to make trip.)= Sorensen E, G Burgreen, J Antaki. Simulation of platelet-mediated thrombogenesis. Proceedings: Biomedical Engineering Society Annual Fall Meeting, 10/10-12/1998. Morse, N, R Smith, B Paden and J Antaki. Position sensed and self-sensing magnetic bearing configurations and associated robustness limitations. In: Proceedings of the 37th IEEE Conference on Decision and Control, 16-18 Dec. 1998. (Cat. No.98CH36171), pp 2599-2604, Burgreen, GW and JF Antaki. CFD-based design optimization of a three-dimensional turbo blood pump. In Proceedings: The 1998 ASME International Mechanical Engineering Congress and Exposition, , Nov 15-20, Anaheim, CA, vol. 39, pp. 87-88. He B, O Ghattas, JF Antaki. Continuous shape sensitivity of incompressible Navier-Stokes flows. Proceedings: 7th Multidisciplinary analysis and optimization, AIAA ISSUE 4701/4796; NUMBER 1 pp. 430-440, 1998. Burgreen G, J Antaki, and K Butler. CFD-Based Design Optimization of the Outlet Stator of a Rotodynamic Cardiac Assist Device. Proceedings: 7th Multidisciplinary analysis and optimization, AIAA ISSUE 4701/4796; NUMBER 1 pp. 430-440, 1998. Wu ZJ, GW Burgreen, D Thomas, KC Butler, BP Griffith, JF Antaki. Visualization of flow features in a miniature axial flow blood pump using laser-based fluorescent particle imaging technique. Proceedings: 8 th International Symposium on Flow Visualization, Sorrento, Italy, 9/1-4/1998.

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Gottlieb RK, ZJ Wu, HS Borovetz, JF Antaki. Calibration of a liquid crystal shear stress sensor for viscous flow. Proceedings: 8th International Symposium on Flow Visualization, Sorrento, Italy, 9/1998. *Antaki JF. Computer optimization and magnetic bearing: Future of the Mechanical Heart. ASAIO 44 th Annual Conference, New York, NY, 4/25/1998. =Invited Panelist= Amin D, JF Antaki, P Litwak, D Thomas, J Wu, M Watach. Induction of ventricular collapse by axial flow blood pump. ASAIO J, 44:M685-M690, Proceedings: 44th Annual Conference, New York, NY, 4/1998. Burgreen GW, JF Antaki, J Wu, P LeBlanc, KC Butler, RL Kormos. A computational and experimental comparison of two outlet stators for the Nimbus LVAD. ASAIO J, 44:2, Proceedings: 44 th Annual Conference, New York, NY, 4/1998. Wu J, JF Antaki, GW Burgreen, K Butler, D Thomas, BP Griffith. Fluid dynamic characterization of operating conditions for continuous flow blood pumps. ASAIO J, 44:2, Proceedings: 44th Annual Conference, New York, NY, 4/1998. Watach MJ, MV Kameneva, P Litwak, JF Antaki, KC Butler, D Thomas, LP Taylor, HS Borovetz, RL Kormos, BP Griffith. Chronic animal health assessment during axial ventricular assistance: importance of hemorheological parameters. Proceedings: 44th Annual ASAIO Conference, New York, NY. ASAIO J, 44:2, 1998. Thomas D, K Butler, L Taylor, P LeBlanc, B Griffith, R Kormos, H Borovetz, P Litwak, M Kameneva, S Choi, G Burgreen, J Wu, J Antaki. Progress on Development of the Nimbus - University of Pittsburgh Axial Flow Left Ventricular Assist System. Proceedings: 44 th Annual ASAIO Conference, New York, NY, ASAIO J, 44(5): M521-M524, 1998 Yu Y-C, M Simaan, JR Boston, PJ Miller, JF Antaki. Estimation of blood pump parameters for cardiovascular system identification. International Conference on Acoustics, Speech, and Signal Processing, 2381-2384, Seattle WA, 5/12-15/1998. Boston JR, MA Simaan, JF Antaki, Y-C Yu, S Choi. Intelligent control design for heart assist devices. Proceedings: 1998 ISIC/CIRA/ISAS Joint Conference, 497-502, Gaithersburg, MD, 9/14-17/1998. Curtis A, ZJ Wu, JF Antaki. Application of bioluminescent plankton for shear stress measurement within circulatory assist components. International Conference on Mechanics in Medicine and Biology, Honolulu, HI, 3/2-5/1998. Yamazaki, K, T Mori, J Tomioka and JF Antaki. The "Cool Seal" Concept: A Low-Temperature Mechanical Seal with Recirculating Purge System for Rotary Blood Pumps. In: Artificial Heart (6th International symposium, Artificial heart and assist devices, July 1996, Tokyo, Japan) Akutsu, T.; Koyanagi, H. (eds.), Springer-Verlag, Tokyo, pp 337-343, 1998 Konishi, H, Y Misawa, JF Antaki, and RL Kormos. A New Index for Characterizing Pulsatility: Recovery of Renal Function. In: Artificial Heart (6th International symposium, Artificial heart and assist devices, July 1996, Tokyo, Japan) Akutsu, T.; Koyanagi, H. (eds.), Springer-Verlag, Tokyo, pp 337-343, 1998. Antaki JF and JR Boston. Control issues in artificial organs. 13th World Congress of the International Federation of Automatic Control (IFAC), San Francisco, CA, June 1996, p 113. Pergamon, 1997. Antaki JF, GW Burgreen KK Yeleswarapu, MV Kameneva. Towards a unified model for shear-induced blood cell damage. Ann Biomed Eng, special issue: 1997 Annual Fall Meeting of the Biomedical Engineering Society, 137, San Diego, CA, 10/2-7/1997. Curtis AS, J Wu, J Antaki. Transparent left ventricle for flow visualization of apical cannula. Annual Biomed Eng, special issue: 1997 Annual Fall Meeting of the Biomedical Engineering Society, 168, San Diego, CA, 10/2-7/1997. Sorensen E, G Burgreen, J Antaki. Modeling of platelet-mediated thrombogenesis. Annual Biomed Eng, special issue: 1997 Annual Fall Meeting of the Biomedical Engineering Society, 305, San Diego, CA, 10/27/1997. Choi S, JR Boston, D Thomas, JF Antaki. Modeling and identification of an axial flow pump. Proceedings: American Control Conf., vol. 6, 3714-3715, Albuquerque, NM, 6/4-6/1997. Antaki JF, BE Paden, GW Burgreen, NJ Groom, MV Kameneva, Z Wu, JA Holmes, BP Griffith. The “Streamliner:” A new mixed flow blood pump with magnetic bearings. 5 th Congress of the International Society for Rotary Blood Pumps, Marseille, France, 9/10-12/1997. Antaki JF, S Choi, D Thomas, D Amin, P Litwak, Z Wu, JR Boston. In search of... Chronic speed control for rotary blood pumps - 2: Architecture, algorithms, and setpoints (poster presentation). 5 th Congress of the International Society for Rotary Blood Pumps, Marseille, France, 9/10-12/1997.

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Yamazaki K, P Litwak, O Tagusari, JF Antaki, M Kameneva, M Watach, L Gordon, T Mori, J Tomioka, M Umezu, E Outa, H Koyanagi, RL Kormos, BP Griffith. A totally implantable centrifugal blood pump for long-term circulatory support. 5th Congress of the International Society for Rotary Blood Pumps, Marseille, France, 9/10-12/1997. Antaki J. Alternative Power Supplies for Artificial Organs - Panel Presentation. D. Farrar, Chair, ASAIO, Atlanta, GA, 1997. Kameneva MV, H Borovetz, J Antaki, M Watach, R Kormos, B Griffith. Partial plasma replacement with perfluorocarbon emulsion significantly reduced mechanical trauma to blood in-vitro. International Society for Artificial Organs, Providence, RI, 6/29 – 7/1/1997. Kameneva MV, A Ündar, J Antaki, M Watach, J Calhoun, H Borovetz. Red blood cell impairment due to the combined effect of mechanical stress, hypothermia and hemodilution: Factors related to cardiopulmonary bypass (CPB). International Society for Artificial Organs, Providence, RI, 6/29 – 7/1/1997. Antaki JF, GW Burgreen, BE Paden, O Ghattas, B He, MV Kameneva, KK Yeleswarapu, BP Griffith. Computer optimization strategies for magnetically levitated rotary blood pump. Proceedings: First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mathematics, 6/6-9/1997. He B, O Ghattas, JF Antaki. Computational Strategies for Shape Optimization of Time-Dependent Navier-Stokes Flows. Technical Report CMU-CML-97-102, Computational Mechanics Lab, Department of Civil and Environmental Engineering, Carnegie Mellon University, 6/1997. Yeleswarapu KK, JF Antaki et al. Proceedings: First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mathematics, June 6-9, 1997. Kameneva MV, JF Antaki, HS Borovetz, MJ Watach, BP Griffith. Small particles of perfluorocarbon emulsion may protect blood cells from mechanical damage in high shear flow. Proceedings: First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mathematics, 6/6-9/1997. Yu Y-C, JF Antaki, JR Boston, M Simaan, PJ Miller. Mathematical model of pulsatile blood pump for LVAS control. Proceedings: 16th American Control Conference, vol. 6:3709-3713, Albuquerque, NM, June 4-6, 1997. Tagusari O, K Yamazaki, P Litwak, A Kojima, JF Antaki, M Watach, A Holmes, T Mori, H Koyanagi, BP Griffith, RL Kormos. Fine Rahmen structure of carbon (fine trabecularized carbon): new process of carbon for soft-tissue-anchored percutaneous device system. ASAIO J, 43:2, Proceedings: 43 rd Annual Conference, 3, Atlanta, GA, 5/1-3/1997. Kameneva MV, A Undar, JF Antaki, MJ Watach, JH Calhoun, HS Borovetz. Impaired RBC deformability may contribute to the brain damage which occurs in hypothermic cardiopulmonary bypass in infants. ASAIO J, 43:2, Proceedings: 43rd Annual Conf., 33, Atlanta, GA, 5/1-3/1997. Burgreen GW, JF Antaki, BP Griffith. Computational fluid dynamics based design optimization of an axial flow blood pump. ASAIO J, 43:2, Proceedings: 43rd Annual Conference, Atlanta, GA, 5/1-3/1997. Yamazaki K, P Litwak, RL Kormos, O Tagusari, JF Antaki, M Kameneva, M Watach, L Gordon, T Mori, M Umezu, J Tomioka, H Koyanagi, BP Griffith. A Totally implantable centrifugal blood pump for longterm circulatory support. ASAIO J, 43:2, Proceedings: 43 rd Annual Conference, 51, Atlanta, GA, 5/13/1997. Kameneva MV, JF Antaki, KK Yeleswarapu, MJ Watach, HS Borovetz. Plasma protective effect on red blood cells exposed to mechanical stress. In Proceedings: 43rd Annual Conference, 51, Atlanta, GA, 5/13/1997. ASAIO J, 43:2, 1997. Yamazaki K, O Tagusari, P Litwak, BP Griffith, T Mori, J Tomioka, JF Antaki, H Koyanaki, RL Kormos. The “cool-seal” system: a low temperature mechanical seal with recirculated purge system for rotary blood pumps. In Proceedings: 43rd Annual Conference, 51, Atlanta, GA, 5/1-3/1997, ASAIO J, 43:2, 1997. Yamazaki K, RL Kormos, P Litwak, O Tagusari, JF Antaki, M Kameneva, M Watach, L Gordon, T Mori, M Umezu, J Tomioka, BP Griffith, H Koyanagi. In-vivo evaluation of an intraventricular axial flow blood pump (IVAP). In Proceedings: 43 rd Annual Conference, 51, Atlanta, GA, 5/1-3/1997, ASAIO J, 43:2, 1997. Thomas D, K Butler, L Taylor, P LeBlanc, B Griffith, R Kormos, H Borovetz, P Litwak, M Kameneva, S Choi, J Wu, J Antaki. Continued development of the Nimbus-Pittsburgh (University of Pittsburgh) axial flow left ventricular assist system. In Proceedings: 43 rd Annual Conference, 52, Atlanta, GA, May 1-3,

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1997. ASAIO J, 43(5): M564-566, 1997. *Antaki JF, GW Burgreen, O Ghattas, BE Paden, NJ Groom, B He, MV Kameneva, KK Yeleswarapu, JP Kerrigan, HS Borovetz, RL Kormos, BP Griffith. Holistic design paradigm for an axial flow ventricular assist blood pump. Annual Biomed Eng, 24, supp. 1, Proceedings: Biomedical Engineering Society, S-5, Penn State, PA, 10/1996. =Invited Presentation= Kameneva MV, GW Burgreen, JF Antaki, MJ Watach, HS Borovetz. Red blood cell trauma in assisted circulation: effects of heat, species, plasma components and osmotic pressure. Annual Biomed Eng, 24, supp. 1, Proceedings: Biomedical Eng Society, S-40, Penn State, PA, 10/1996. Yeleswarapu KK, JF Antaki, MV Kameneva, KR Rajagopal. Effect of shear thinning on pulsatile blood flow. Annual Biomed Eng, 24, supp. 1, Proceedings: Biomedical Engineering Society, S-44, Penn State, PA, 10/1996. Yamazaki K, T Mori, J Tomioka, T Kitano, JF Antaki, H Koyanagi, RL Kormos. The "cool seal" concept: A low temperature mechanical seal with recirculated purge system for rotary blood pumps. Proceedings: 6th International Symposium on Artificial Heart & Assist Devices, Tokyo, 7/30-31/1996. Yamazaki K, RL Kormos, JF Antaki, T Mori, O Tagusari, H Jukuo, M Kameneva, P Litwak, J Kerrigan, M Watach, M Umezu, J Tomioka, H Koyanagi. In-vivo evaluation of an intraventricular axial flow blood pump (IVAP), ibid. *Antaki JF, S Choi, D Amin, JR Boston, Y-C Yu, JP Kerrigan, H Konishi, P Litwak, HS Borovetz, D Thomas, BP Griffith. In search of... Chronic speed control for rotary blood pumps. Proceedings: Waseda International Congress of Modeling and Simulation Technology for Artificial Organs, 6-7, Tokyo, Japan, 8/1-3/1996. =Invited Presentation= Lehman KA, JF Antaki, JC Woodard, JR Boston. A Starling-responsive mock circulatory loop for ventricular assist hemodynamic simulation. Proceedings: Waseda International Congress of Modeling and Simulation Technology for Artificial Organs, Tokyo, Japan, 8/1-3/1996. Mukuo H, K Yamazaki, M Umezu, JF Antaki, T Mori, O Tagusari, M Kameneva, RL Kormos, JP Kerrigan. Hemocompatibility improvement of axial flow blood pump. Proceedings: Waseda International Congress of Modeling and Simulation Technology for Artificial Organs, Tokyo, Japan, 8/1-3/1996. Meyer RK, HS Borovetz, KK Yeleswarapu, JF Antaki. Liquid crystal technique for measurement of fluid shear stress at blood-wall boundary. Proceedings: 1st Pacific Symposium of Flow Visualization and Image Processing, Honolulu, HI, 11/1996. Kameneva MV, GW Burgreen, JF Antaki, MJ Watach, HS Borovetz. Red blood cell trauma in assisted circulation - effects of heat, species, plasma components and osmotic pressure. Proceedings: BMES, 10/1996. Burgreen GW and JF Antaki. CFD-Based design optimization of a three-dimensional rotary blood pump. A Collection of Technical Papers: 6th AIAA/NASA/USAF/ISSMO Symposium on Multidisciplinary Analysis and Optimization, Bellevue, WA, September 1996, pp 1773-1778. 1996. [Voted one of best 10 papers at the Symposium] Yu Y-C, JR Boston, M Simaan, and JF Antaki. An identification scheme for the estimation of the parameters of a model of the cardiovascular system. Proceedings: 13th World Congress, International Federation of Automatic Control., San Francisco, CA, June 30, 1996. Butler K, L Taylor, D Thomas, J Antaki, H Borovetz and P Litwak. SBIR supported rotary blood pump technology at Nimbus Annual Meeting of the Association for the Advancement of Medical Instrumentation, 1-5 Jun 1996, Philadelphia, PA. Butler K, L Taylor, D Thomas, P Litwak, J Antaki, M Kameneva, M Macha, H Borovetz, R Kormos, B Griffith. An axial flow pump-based LVAS for bridge to cardiac transplantation. Proceedings: ASAIO, 5/1996. Thomas D, K Butler, P LeBlanc, P Litwak, J Antaki, H Borovetz, J Kerrigan, M Kameneva, M Macha, R Kormos, B Griffith. Innovative ventricular assist system. Proceedings: ASAIO, 5/1996. Yamazaki K, RL Kormos, JF Antaki, T Mori, H Mukuo, M Kameneva, J Kerrigan, P Litwak, M Macha, M Watach, M Umezu, J Tomioka, BP Griffith, H Koyanagi. In-vivo evaluation of an intraventricular axial flow blood pump (IVAP). Proceedings: ASAIO, 42(2) 47, 1996. Kameneva MV, GW Burgreen, HS Borovetz, P Litwak, MJ Watach, RL Kormos, JF Antaki. On mechanisms of red blood cell trauma in assisted circulation II: Thermo-damage. Proceedings: ASAIO, 42(2) 38, 1996. Macha M, P Litwak, K Yamazaki, M Kameneva, J Kerrigan, JF Antaki, H Borovetz, K Butler, D Thomas,

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L Taylor, R Kormos, B Griffith. In vivo evaluation of an extracorporeal pediatric centrifugal blood pump. Proceedings: ASAIO, 42(2) 40, 1996. Macha M, P Litwak, K Yamazaki, M Kameneva, J Kerrigan, JF Antaki, H Borovetz, K Butler, D Thomas, L Taylor, R Kormos, B Griffith. Six month survival in a calf supported with an implantable axial flow ventricular assist device. In Proceedings: ASAIO, 42(2) 40, 1996. Burgreen GW, JF Antaki, BP Griffith. A design improvement strategy for axial blood pumps by computational fluid dynamics. In Proceedings: ASAIO, 42(2) 47, 1996. Borovetz, H, J Antaki, W Wagner, M Kameneva, J Pristas, S Winowich, W Mandarino, P Litwak, R; Kormos, and B Griffith. Biomechanics and testing of mechanical circulatory support devices. In Proceedings: The 1996 11th Conference on Engineering Mechanics. Part 1 (of 2), 05/19-22/96, Fort Lauderdale, FL, 1:35, 1996. Ghattas O, B He, GW Burgreen, JF Antaki. Shape optimization of viscous incompressible flows. Proceedings: SIAM, 1996. Yamazaki, R Kormos, M Kameneva and J Antaki. Low Hemolytic Intraventricular Axial Flow Blood Pump Integrated with Totally Implantable Bearing Purge System. In: Artificial Heart (5th International symposium, Artificial heart and assist devices, July 1995, Tokyo, Japan) Akutsu, T.; Koyanagi, H. (eds.), Springer-Verlag, Tokyo, pp 69-76, 1996. Yamazaki, K, M Kameneva, W Wagner, and J Antaki. Bearing Seizure in a Rotational Blood Pump: Mechanism and Potential Solutions. In: Artificial Heart (5th International symposium, Artificial heart and assist devices, July 1995, Tokyo, Japan) Akutsu, T.; Koyanagi, H. (eds.), Springer-Verlag, Tokyo, pp 371376, 1996. Antaki JF, O Ghattas, GW Burgreen, B He, J Cagan, HS Borovetz. Computerized multidisciplinary design optimization of circulatory support systems. Annals of Biomedical Engineering: Abstract Supplement for the Biomedical Engineering Society, S-25, Boston, MA, 10/6-8/1995. Butler K, D Thomas, T Rintoul, H Harty, L Taylor, H Borovetz, J Antaki, R Kormos, B Griffith, P Litwak. Rotary blood pump development at Nimbus. Annals of Biomedical Engineering: Abstract Supplement for the Biomedical Engineering Society, S-25, Boston, MA, 10/6-8/1995. Kameneva MV, HS Borovetz, JF Antaki. Effect of perfluorochemical emulsion on blood mechanical trauma. Annals of Biomedical Engineering: Abstract Supplement for the Biomedical Engineering Society, S-25, Boston, MA, 10/6-8/1995. Kameneva MV, HS Borovetz, JF Antaki, P Litwak, W Federspiel, RL Kormos, BP Griffith. Effect of perfluorochemical emulsion on hemorheology and shear induced blood trauma: Possible mechanisms and future applications. Proceedings: International Society on Oxygen Transport to Tissue, Pittsburgh, PA, 1995. Yu Y-C, JR Boston, J Antaki, M Simaan, DS Breitenstein. Estimation of cardiovascular bed parameters. Annals of Biomedical Engineering: Abstract Supplement for the Biomedical Engineering Society, Boston, MA, S-44, 10/6-8/1995. Yeleswarapu KK, JF Antaki, MV Kameneva, KR Rajagopal. Pulsatile flow of a generalized Oldroyd-B model for blood. Annals of Biomedical Engineering: Abstract Supplement for the Biomedical Engineering Society, Boston, MA, 44, 10/6-8/1995. Yamazaki K, R Kormos, M Kameneva, J Antaki, P Litwak, J Kerrigan, J Tomczak, H Konishi, M Macha, H Borovetz, T Mori, E Outa, M Umezu, B Griffith, H Koyanagi. Intraventricular axial flow blood pump integrated with a purged-seal system. Proceedings: 3rd International Society of Rotary Blood Pumps, 1995. Konishi H, J Antaki, J Kerrigan, D Amin, et al. Controller for an axial flow blood pump. Proceedings: 3 rd International Society of Rotary Blood Pumps, 1995. Kerrigan J, K Yamazaki, R Meyer, T Mori, Y Otake, E Outa, M Umezu, H Borovetz, R Kormos, B Griffith, H Koyanagi, J Antaki. Particle tracking flow visualization within an intra-ventricular axial flow assist device. Proceedings: 3rd International Society of Rotary Blood Pumps, 1995. Yu Y-C, JR Boston, JF Antaki, M Simaan, DS Breitenstein. Parameter estimation in cardiovascular models. Proceedings: 17th Annual International conference IEEE/EMBS, Montreal, 9/20-23/1995. *Antaki JF. Autonomous control of rotary blood pumps. "Feedback Artificial Organ Systems," ASAIO 41st Annual Conference, Chicago, IL, 5/1995. =Invited Panelist= Konishi H, JF Antaki, WA Mandarino, S Winowich, JP Kerrigan, HS Borovetz, RL Kormos, BP Griffith. Clinical flow criteria for rotary blood pump LVAD. Proceedings: ASAIO, 1995. Williams JL, JF Antaki, JR Boston, SL Williams, JC Woodard, PJ Miller, RL Kormos. Load-sensitive

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mock circulatory system for left ventricular assist device controller evaluation and development. Proceedings: ASAIO, 1995. Yamazaki K, M Kameneva, W Wagner, J Antaki, J Tatka, J Kerrigan, P Litwak, H Konishi, M Macha, J Tomczak, Z Yang, H Borovetz, R Kormos. Bearing seizure in a rotational blood pump: mechanism and potential solutions. Proceedings: ASAIO, 1995. Kameneva MV, JF Antaki, H Konishi, JP Kerrigan, MJ Watach, HS Borovetz, RL Kormos, BP Griffith. Effect of perfluorochemical emulsion (FLUOSOL) on shear induced blood trauma. Proceedings: XI Congress of the International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Boston, MA, 1995. Kameneva, MV, Borovetz, HS, and Antaki, JF. On mechanisms of the effect of perfluorochemical emulsion on blood trauma and hemorheology. In. Proceedings 9th International Congress of Biorheology and the 2nd International Conference on Clinical Hemorheology. July 23-28, Big Sky, Montana. Biorheology 32 (2-3) 1995, 327, 1995. Yeleswarapu, KK, Antaki JF, Kameneva, MV, and Rajagopal, KR. A 3-D constitutive equation that describes the shear thinning and the viscoelastic behavior of blood. In. Proceedings 9th International Congress of Biorheology and the 2nd International Conference on Clinical Hemorheology. July 23-28, Big Sky, Montana. Biorheology 32 (2-3) 1995, 313, 1995. Kerrigan JP, JF Antaki, TR Maher and FD Shaffer. Quantitative measurement of steady flow patterns in a miniature axial flow blood pump using fluorescent image tracking velocimetry. Proceedings: ASME Fluids Engineering Division Summer Meeting, Lake Tahoe, NV, June 19-23, pp 155-160, 1994. Butler KC, T Maher, DC Thomas, HS Borovetz, JF Antaki, and P Litwak. Design and development of miniature axial flow blood pumps. In : Proceedings of the 1994 International Mechanical Engineering Congress and Exposition, Chicago, IL, USA. Advances in Bioengineering American Society of Mechanical Engineers, Bioengineering Division ASME Publication BED 28:29-30, 1994. Williams JL, JF Antaki, JR Boston, SL Williams, JC Woodard, PJ Miller and RL Kormos. A load sensitive mock circulatory system for left ventricular assist device controller evaluation and development. Proceedings: IEEE/EMBS 16th Annual International Conference, November 1994, Baltimore, MD, pp 8990, 1994. Yeleswarapu KK, JF Antaki, MV Kameneva and KR Rajagopal. A generalized Oldroyd-B model as a constitutive equation for blood. Proceedings: 1994 Annual Fall Meeting of the Biomedical Engineering Society, Tempe, AZ, 10/14-16/1994. Kameneva, MV, JF Antaki, H Konishi, HS Borovetz, RL Kormos, and BP Griffith. Effect of perfluorochemical emulsion (FLUOSOL) on shear induced blood trauma. In Proceedings: The 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI), Boston, MA, 07/24-27/94, 22(5): A108, 1994. Ghattas O, JF Antaki, TJ Dennis and B He. Towards optimal design of an artificial heart. Workshop on Optimal Design and Control, Blacksburgh, VA, 4/8-9/1994. Antaki JF, TJ Dennis, O Ghattas, and B He. Shape optimization of Navier-Stokes flows with application to optimal design of artificial heart components. A Collection of Technical Papers: 5 th AIAA/NASA/USAF/ISSMO Symposium on Multidisciplinary Analysis and Optimization, 1202-1212, Panama City, FL, 9/7-9/1994. Konishi H, JF Antaki, JR Boston, JP Kerrigan, WA Mandarino, KC Butler, RL Kormos. Controller for an axial flow blood pump LVAD. Proceedings: ASAIO, 1994. Kameneva MV, JF Antaki, et al. Sheep model in the study of hemorheology with assisted circulation: Effect of axial flow blood pump. Proceedings: ASAIO, 1994. Butler KC, TR Maher, RL Kormos, BP Griffith, P Litwak, H Konishi, K Yamazaki, JF Antaki. Development of an implantable axial flow blood pump. Proceedings: Cardiovascular Science and Technology Conference, 12/10-12/1993. Butler K, T Maher, H Borovetz, J Antaki. Implanted rotary blood pumps - Development challenges. Ann Biomed Eng (abstracts), 18, 1993 Annual Fall Meeting of BMES, 10/21-24/1993. Gartner MJ, SC Kowalski, M Chakrabarti, JF Antaki. Optimal design of an impeller blood pump. Proceedings: 10th Annual Fluent Inc. Users Group Meeting, 1993. Kameneva MV, JF Antaki, MJ Watach, HS Borovetz, RL Kormos. Heparin effect on red blood cell aggregation. Clinical Hemorheology (Abstracts). 13(3):284, 1993. Antaki JF, SS Tong, MJ Gartner, TJ Dennis, HS Borovetz, RL Kormos, BP Griffith. Optimal design of

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impeller blood pump based on computational fluid dynamics and genetic algorithms. Proceedings of the American Society for Artificial Internal Organs 39 th Annual Meeting, 37, 1993. Dennis TJ, A Kawai, RL Kormos, JP Kerrigan, M Cahn, BP Griffith, JF Antaki. In-vitro and in-vivo evaluation of ventricular cannula tip for a rotary blood pump. Proceedings of the American Society for Artificial Internal Organs 39th Annual Meeting, 37, 1993. Gartner MJ, JF Antaki, M Shakrabarti, CH Amon, HS Borovetz. A computational fluid dynamics analysis within the outflow valve housing of a circulatory assist device. Proceedings of the American Society for Artificial Internal Organs 39th Annual Meeting, 38, 1993. Konishi H, JF Antaki, JR Boston, HS Borovetz, JP Kerrigan, WA Mandarino, KC Butler, RL Kormos. Left atrial pressure (LAP) controller for an axial flow blood pump. Proceedings of the American Society for Artificial Internal Organs 39th Annual Meeting, 36, 1993. *Antaki JF, KR Rajagopal, HS Borovetz. Material identification of myocardium in the intact heart: Experimental and Theoretical Considerations. Proceeding of the Society of Engineering Science, 1992. =Invited Paper= Gartner MJ, JF Antaki. Modeling the outflow region of a typical circulatory assist device using NEKTON: A feasibility study. Proceedings: Fluent, Inc. User's Group Meeting, 260-271, Burlington, VT, 1992. Butler KC, TR Maher, RL Kormos, BP Griffith, HS Borovetz, JF Antaki. Development of an implanted axial flow LVAS. Proceedings: Cardiovascular Science and Technology Conference, 173, 12/12-14/1992. Labadie RF, JF Antaki, S Datayal, J Ligush, HS Borovetz. Bioengineering-biological study of arterial disease. Proceedings: Cardiovascular Science and Technology Conference, 97, 12/12-14/1992. Labadie RF, S Follonier, HS Borovetz, J Ligush Jr., JF Antaki. An in-vitro hemodynamic replication system to be used for exposing vascular tissue to precisely controlled hemodynamics. Advances in Bioengineering (Recipient of 1992 Student Paper Competition), ASME Pub BED-Vol. 22:497-500, 1992. Shaffer F, M Mathur, J Woodard, H Borovetz, R Schaub, J Antaki, R Kormos, B Griffith, R Srinivasan, R Singh, C McCreary. Fluorescent image tracking velocimetry applied to the Novacor left ventricular assist device. Proceedings: ASME Fluids Engineering Conference, Los Angeles, CA, 7, 1992. Kormos RL, HS Borovetz, JM Armitage, RL Hardesty, GC Marrone, BP Griffith. Evolving experience with mechanical circulatory support. Annual Surg (Acknowledgment to JF Antaki), 214(4):471-477, 1991. Antaki JF, MS Rosenthal, HS Borovetz. Use of gated MR imaging with implanted markers for cardiac biomechanical modeling. Proceedings: Cardiovascular Science and Technology Conference, AAMI, 32, 12/2-4/1991. Woodard J, F Shaffer, R Schaub, L Lund, J Antaki, HS Borovetz. Flow visualization of the Novacor left ventricular assist system (LVAS). Proceedings: Cardiovascular Science and Technology Conference, AAMI, 122, 12/2-4/1991. Butler KC, RK Wampler, TR Maher, BP Griffith, RL Kormos, JF Antaki, HS Borovetz. Demonstration and evaluation of an implantable axial flow blood pump. Proceedings: Cardiovascular Science and Technology Conference, AAMI, 122, 12/2-4/1991. Butler KC, RK Wampler, BP Griffith, JF Antaki, RL Kormos, HS Borovetz. Development of an implantable axial flow LVAS. Intl. Symposium on Rotary Blood Pumps, 148-153, Vienna, 1991. Vorp DA, PA Smolinski, KR Rajagopal, HS Borovetz, JF Antaki. Development and validation of a finite element program to model vascular tissue. Proceedings: 1 st US Congress on Computational Mechanics, Chicago, IL, 7/1991. Antaki JF, KR Rajagopal, MS Rosenthal, DA Vorp, MJ Gartner, HS Borovetz. An experimental and theoretical model for the passive biomechanical properties of the intact heart. Proceedings: 13 th Annual International Conference, IEEE/EMBS, 10/1991. Antaki JF, RL Kormos, MJ Gartner, BP Griffith, HS Borovetz. Right ventricular pressure-segment relations following left ventricular assist in man: A case study. ASME publication AMD-Vol. 98:269-272, 1989. Antaki JF, JM Pristas. An improved transducer insertion tool for sonomicrometry. Proceedings: AAMI 23rd Annual Meeting and Exposition, 12, 1988. Antaki JF, JM Pristas. Construction of segment length crystals for sonomicrometry. Internal Report, University of Pittsburgh Department of Surgery, 1988.

SUMMARY OF INVITED PRESENTATIONS & SEMINARS (overlap with lists above)

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note to self: re-organize according to CMU format: Proceedings; Seminars; Conf Presentations 2015 1.

Antaki, JF, Debate: LVADs versus Transplantation (Engineering perspective). ASAIO annual conference, Chicago, IL, June 2015. (no published abstract)

2.

Antaki, JF, Multi-scale Challenges for Simulation of Thrombosis in Blood-Wetted Devices, BMES/FDA Frontiers in Medical Device Conference: Innovations in Modeling and Simulation.

3.

Antaki, JF and J Zell, …. Venturewell, Washington DC 2015

2014 4.

Antaki, JF, A Daly, M Jamiolkowski, M Kameneva, A Martin, P Menon, W Wagner, W Wu. Trafficking of Platelets and Red Blood Cells: Theoretical and Experimental Models; World congress of biomedical engineering, San Antonio, TX, July 2014

2013 5.

Loghmanpour, N, J Antaki, M Kanwar, Y Wang, T Snyder, D Horstmanshof, J Long, J Gorcsan, S Murali. Designing a Clinical Decision Support System Using Bayesian Networks: A Predictive Tool and UserFriendly Interface, A GRC and GRS Assisted Circulation “Reducing Adverse Events and Improving Quality of Life through Design, Control and Management of Rotary Blood Pumps: Clinical and Engineering Approaches” (Poster Presentation), June XX, Italy, 2013

2012 2011 2010 2009 6.

Antaki, J. Optimal feedback control for ventricular recovery and right ventricular function. Gordon Research Conference on Assisted Circulation, Waterville, NH, Sept 6-11, 2009.

7.

Hund, S and JF Antaki, “Multiscale modeling of thrombosis in assisted circulation." Second Annual NIH/NSF/FDA Symposium on Computer Simulation for Design of Medical Devices, Washington DC, June 2009.

2008 2007 2006 8.

Antaki, JF, The Biomedical Engineer-Entrepreneur of the Future. Clarkson University, Jan 30, 2006 (seminar)

2005 9.

“Control Systems for Assisted Circulation: Emerging Trends,” Gordon Research Conference, Assisted Circulation, August 21-August 26, 2005, Big Sky, Montana.

10.

“Advances in Quantitative Biomedical Models.” American Society of Artificial Internal Organs, Washington DC, June 10, 2005.

11.

“Design of Pediatric Heart-Assist Devices: Hemorheological Challenges & Opportunities,” Drexel University, Department of Biomedical Engineering, Philadelphia, PA. May 20, 2005.

12.

“Prescriptive Design of Pediatric VADs.” First International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, Hershey, PA – May 19-21, 2005

2004 13.

“Design of Pediatric Heart-Assist Devices: Modeling Challenges & Opportunities” Civil Engineering

JF Antaki, pg 58 of 62

Department, Carnegie Mellon, November 17, 2004. 14.

Optimal Design of Blood Flow within Artificial Hearts Devices on Terascale Supercomputers, 41st Annual SES Technical Meeting, Lincoln, Nebraska Oct 10, 2004.

15.

“Pediatric Blood Pumps of Pittsburgh.” International Society of Rotary Blood Pumps, Cleveland, OH, October 2004.

16.

“Future Opportunities for Innovation of Artificial Organs,” American Society of Artificial Internal Organs, Washington, DC, June 2004.

17.

“Medical Device Innovation and Optimization at CMU,” MIRM Scientific Retreat, Ligonier, PA, 2/23/2004

18.

“Laboratory for Optimization of Innovative Medical Devices” MERITS Industry Day, Pittsburgh 1/2004.

19.

“The Hitchhikers’s Guide to Technical Presentations” CMU Biomedical Engineering Seminar Series, 1/2004.

2003 20.

Antaki JF, Microstructural modeling of hemorheology and hemolysis, Response of Blood to Mechanical Circulatory Support, First International Conference on Medical Implants, Bethesda, MD, July 25, 2003. =Invited=

21.

“Challenges of Control of Rotary Blood Pumps,” American Society of Artificial Internal Organs, Washington, DC, June 2003

2002 22.

Design of Replacements for Human Organs. Stanford Research International, Menlo Park, CA, 5/10/2002. =Invited Lecture=

23.

Mechanical Substitutes for Human Organs. American Society of American Engineers regional meeting, Pittsburgh, PA, 2/19/2002. =Invited Lecture=

24.

Designing Mechanical Replacements for the Human Heart. National Science Foundation Design, Service and Manufacturing Grantees and Research Conference, San Juan, PR, 1/7-10/2002. =Keynote Lecture=

2001 25.

Mechanical Substitutes for Human Organs. American Society of Mechanical Engineers, International Design Engineering Technical Conference, Pittsburgh, PA, 9/9-12/2001 =Keynote Lecture=

26.

Computer Simulation and Optimization of Blood Flow in Streamliner Artificial Heart. Texas A&M University, 4/11/2001.

200 27.

Phonetics and Physiology of Harmonica Playing. Second Global Harmonica Summit, Minneapolis, MN, 7/2000.

28.

Development of Pittsburgh’s Artificial Heart: What a Long Strange Trip it’s Been. Carnegie Mellon University, Mechanical Engineering, Seminar Lecture Series, 2/18/2000.

29.

Innovation in Artificial Organ Technology: Crossroads of Biomedicine and Attention Deficit Disorder. University of Pittsburgh Department of Surgery, Grand Rounds Hospital, 12/1998.

30.

Current and future challenges in artificial heart technology. Carnegie Mellon Computational Mechanics Seminar Series, University of Pittsburgh, 4/4/1997. =Invited=

31.

A Hitchhiker’s Guide to Technical Presentations. Department of Bioengineering Seminar, University of Pittsburgh, 3/14/1997.

32.

Current and Future Trends in Artificial Heart Research. Transplantation Grand Rounds, 5/1995.

JF Antaki, pg 59 of 62

33.

CFD Optimization for Rotary Artificial Heart Components. ICASE/LaRC (Institute for Computer Applications in Science and Engineering/NASA Langley Research Center), Industry Roundtable, Williamsburg, VA, 10/3-4/1994.

34.

Careers in Bioengineering: Academia vs. Industry. Carnegie Mellon University, Society of Women's Engineers, 3/1993.

35.

Hemorheology and Total Viscosity Breakdown. University of Pittsburgh Vascular Conference, 6/29/1992.

36.

Blood Rheology in Device Patients. University of Pittsburgh Transplantation Conf., 3/5/1992.

37.

Use of MRI to Assess Cardiac Mechanics. Univ. of Pittsburgh Transplantation Conf., 9/19/1991.

WORKSHOP AND CONFERENCE ORGANIZATION 2011

Gordon Research Conference on Mechanical Circulatory Support “The Science of Patient-Centered Decision Making.” Session co-organizer, with Lynn Warner-Stevenson, MD.

2009

Biomedical Engineering Society, Annual Meeting, Pittsburgh, PA, October 2009. Conference co-organizer.

2005

First International Conference on Micro BioRheology (ICMBR), Pittsburgh, PA. (co- organized with Tikeswar Naik.)

SCIENTIFIC SESSIONS CHAIRED AND INVITED PANELS 1.

Cardiovascular Devices: Intelligent Design Using Computations and Experiments. (co-Chair with Keefe Manning.) BMES Annual Conference, San Antonio, TX, Oct 23, 2014

2.

Missing data: 2008 – 2014

3.

International Conference on Clinical Hemorheology, The Pennsylvania State University, July 9 -13, 2008. Symposium: Hemorheological aspects of mechanical blood trauma. Co-Chairs: J. Antaki and M.V. Kameneva

4.

First International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, International Program Committee Member, Hershey, PA – May 19-21, 2005

5.

First International Conference on Micro BioRheology. Carnegie Mellon University, Pittsburgh, PA, 2005, co-Organizer (with T. Naik.)

6.

Principles: Engineering Of Artificial Organs, American Society of Artificial Internal Organs, Washington, DC, June 16-19, 2004 (Session Organizer.)

7.

Rotary Blood Pumps, American Society of Artificial Internal Organs, Washington, DC, June 16-19, 2004 (co-Chair with D Olsen)

8.

Computational Fluid Dynamics of Rotary Blood Pumps, International Society of Rotary Blood Pump, August 29, 2003, Bad Oeyenhausen. (co-Chair with Affeld)

9.

Drag-Reducing Polymers in Blood Circulation, Conference on Cardiovascular Medicine & Science, Bethesda, MD, July 24, 2003 (co-chair with MV Kameneva.)

10.

Response of Blood to Mechanical Circulatory Support, First International Conference on Medical Implants, Bethesda, MD, July 25, 2003 (co-chair with MV Kameneva.)

11.

Artificial Heart Control. Second Joint EMBS-BMES Conference, 10/23-26/2002, Houston, TX.

12.

Musical Acoustics: Free Reeds Instruments: Concert Performance Featuring Henry Doktorski, Accordion and Howard Levy, Harmonica. Session co-chair, 6/4/2002, Pittsburgh, PA.

13.

Artificial Organs and Prosthetics. BioMedical Engineering Society (BMES) Annual Fall Meeting, program co-chair, 10/2001.

14.

Engineering Concepts of Rotary Blood Pumps. 9 th Congress of the International Society for Rotary Blood

JF Antaki, pg 60 of 62

Pumps, session co-chair, Seattle, WA, 8/2001. 15.

Computer Optimization and Magnetic Bearing: Future of the Heart. ASAIO 44 th Annual Conference (one of four panelists including, Robert Kung, pres. Abiomed, Peer Portner, Pres. Baxter/Novacor, and Robert Jarvik), New York, NY, 4/25/1998.

16.

Artificial Organs. International Conference on Mechanics in Medicine and Biology, session co-chair, Honolulu, HI, 3/2-5/1998.

17.

SPIE/IS&T (Society for Image Science and Technology) Symposium on Electronic Imaging (Program Committee: “Clinical-Assist Systems”), 1/1998.

18.

Interdisciplinary Project Course on Organ Transplant System. Carnegie Mellon University, Department of Engineering and Public Policy, review panelist, September – December, 1997.

19.

New Ideas in Artificial Organs. Biomedical Engineering Society 1997 Annual Fall Meeting, San Diego, CA, 10/2-5/1997.

20.

Flow Visualization Technology. Waseda International Congress of Modeling and Simulation Technology for Artificial Organs, 8/1-3/1996, Tokyo, Japan.

21.

Artificial Heart Control. International Federation of Automatic Control, session organizer, 6/30 – 7/5/1996.

22.

Distributed Control Systems. International Federation of Automatic Control 6/30 – 7/5/1996.

23.

Artificial Hearts - A Challenge to Control Engineers. Panel Discussion, International Federation of Automatic Control (the "Olympics" of the control community), San Francisco, CA, 6/30–7/5/1996.

24.

Skeletal Muscle Power. ASAIO 42nd Annual Conference, Washington, DC, 5/1996.

25.

Feedback Artificial Organ Systems. ASAIO 41st Annual Conference, , Chicago, IL, 5/1995.

26.

Artificial Heart Design. American Society of Mechanical Engineers, Winter Annual Meeting, Chicago, IL, 11/1994.

27.

Magnetic Levitation. 2nd Congress of the International Society for Rotary Blood Pumps, Vienna Austria, 9/1994.

DISSCUSSIONS OR REVIEWS (PRESS COVERAGE) 1.

Appeal of academic research becoming lost on students, educators alike. MAR 21, 2014, PITTSBURGH BUSINESS TIMES 2. Pitt professor lands $3.4M NIH grant for wearable artificial lung cardiothoracic transplant division EDTSTEEL CITY INNOVATION,PITTSBURGH BUSINESS TIMES, MAR 19, 2013 3. CMU professor turns to Steel City Improv to make point about ideas. Tribune Review, Thursday, Dec. 26, 2013. http://triblive.com/news/allegheny/5224248-74/improv-students-engineering#ixzz2pdDgCtu0 4. Carnegie Mellon project could make surgery in space possible. Tribune Review, Sep 2, 2012. http://triblive.com/news/2487523-74/space-carnegie-gravity-hayden-mellon-astronauts-mars-possibleresearch-surgery#axzz2pdBdXoeF. 5. Pittsburgh Post Gazette, “Heart pump made here brings hope to cardiac patients.” Friday, July 16, 2010 By Mackenzie Carpenter. Read more: http://www.post-gazette.com/pg/10197/1073046114.stm#ixzz0uS8uvF7v 6. Pittsburgh Business Times, “Team races against the clock.” Front Page Business section. July 6-12, 2007. 7. KDKA Sunday Business Page. (Hosted by KDKA-TV's Money & Politics Editor Jon Delano.) Interviewed with senior student design team, regarding BME Design project (The Hug Machine). May, 2007. 8. Voice of America, radio interview. Topic: Artificial Heart Research, October, 2006. 9. KDKA Sunday Business Page. (Hosted by KDKA-TV's Money & Politics Editor Jon Delano.) Interviewed with senior student design team, regarding BME Design project (The Wright Stuff). May, 2006. 10. "Science and Society ", Science and Society, Radio Interview and Podcast: “You've got to have heart". David Lemberg Executive Producer; Jan 25, 2006. 11. KDKA Sunday Business Page. (Hosted by KDKA-TV's Money & Politics Editor Jon Delano.) Interviewed with Tim Corcoran and Stuart Weiler (student) regarding BME Design class. May 15, 2005.

JF Antaki, pg 61 of 62

12. WPGH news: BME Design Class, May 9, 2005. 13. Work Zone: Inventor, engineer and CMU professor draws inspiration from his surroundings, Pittsburgh Post Gazette. Monday, May 02, 2005 . 14. “University of Pittsburgh Medical Center Surgeons Implant HeartMate II Heart Assist Device as Part of U.S. Trial, Wednesday April 14, (Acknowledgement to Antaki contribution, particularly feedbackcontroller.) 15. Thoratec begins Phase I trial of axial-flow HeartMate II, By Don Long, Medical Device Daily, November 24, 2003 (Acknowledgement to Antaki contribution, particularly feedback-controller.) 16. University of Pittsburgh Teaching Times, “A course in integrated bioengineering design.” October, 2002 17. IEEE Control Systems Magazine, Award Winning Control Applications: James Antaki, Siva Banda, Brad Paden, Michael Piovoso (edited by Michael K. Masten), 2002. 18. PittMed Magazine, 1/2001. Ka-Pow: Supercomputing Supercharges Bio-Discovery. 19. Design News, 12/18/2000. Cool Jobs in Engineering: Bioengineer James F. Antaki. 20. Pittsburgh Business Times, 11/27/2000. Pitt heart goes to Market. 21. Scientific American, Summer 2000, Volume 11, Number 2. Spare Parts for Vital Organs. 22. Design News, 6/5/2000, pp98-103. MagLev Pumps Sustain the Wounded Heart. (John Lewis, Bruce Weibusch, eds.) 23. Pittsburgh Magazine, 4/1999. 40 under 40: Meet the new wave of Pittsburgh’s leaders. 24. Pittsburgh Tribune-Review, Business Extra, 3/30/1999. Artificial organ development: Imagineering process leads to innovations. 25. Pittsburgh Post Gazette, 2/15/1999, pA8-A9. How the harmonica master hits his notes. 26. Wall Street Journal, 1/1999, page 1. Artificial Hearts and Artificial Harps. 27. Pittsburgh Magazine, 9/1998, p76-82. Just a Heartbeat Away. 28. Mechanical Engineering, 5/1998. The Mechanics of Anatomy (Greg Paula, assoc ed.). 29. In Pittsburgh, Vital Organs, 6/24/1998. 30. Pittsburgh Tribune, Review, 3/2/1998, page 1. UPMC pumps up heart research. 31. Business Week, 9/22/1997, p 110. Can we end heart disease: Turbo ticker. 32. Impulse Magazine, 9/5/1997. Are you still human (Steve Segal, ed.) 33. WTAE News, 6/1997. The Streamliner. 34. Good Morning America, 6/1997. The Streamliner. 35. Pitt Medicine, Spring 1995. The Streamliner. 36. NASA Spinoff, 1992. Heart Research (Related to myocardial marker design for NMR imaging). 37. Pittsburgh Post Gazette, 4/6/1992. Thigh Muscle may Power Heart Pump. OTHER   

Expert Witness, US Patent: Voice-Controlled Surgical Microscope, c.1987. Participated in design of Inogen Oxygen Concentrator (http://www.inogen.net/) winner of Frost & Sullivan Product of the Year Award 2005, and Medical Design Excellence Award, 2006. May have already won Publisher’s Clearing House sweepstakes.

JF Antaki, pg 62 of 62

Contents ACADEMIC APPOINTMENTS & PROFESSIONAL EXPERIENCE .......................................................................1 RESEARCH ACTIVITIES ...........................................................................................................................................2 PATENTS PENDING ...................................................................................................................................................3 PATENTS ISSUED .......................................................................................................................................................4 ADDITIONAL INVENTIONS (not patented) ..............................................................................................................5 EDUCATION ................................................................................................................................................................6 ADDITIONAL EDUCATION AND TRAINING ........................................................................................................6 TEACHING EXPERIENCE .........................................................................................................................................7 GRADUATE STUDENTS SUPERVISED ...................................................................................................................7 STUDENTS ADVISED – Graduated/Completed {reverse chronological} ..................................................................7 POST-DOCTORAL STUDENTS ............................................................................................................................... 10 ADDITIONAL STUDENTS ADVISED (Outcome) .................................................................................................. 10 UNDERGRADUATE INTERNS ADVISED ............................................................................................................. 10 SENIOR DESIGN PROJECTS ADVISED ................................................................................................................. 10 GRADUATE PROJECTS ADVISED ......................................................................................................................... 11 INTERNATIONAL STUDENTS SPONSORED ....................................................................................................... 11 THESIS COMMITTEE SERVICE – Carnegie Mellon ............................................................................................... 11 THESIS COMMITTEE SERVICE – U Pittsburgh ..................................................................................................... 11 OTHER ACADEMIC SERVICE ACTIVITIES ......................................................................................................... 12 HONORS AND AWARDS ......................................................................................................................................... 13 GRANTS ACTIVE (most recent on top) [NIH Format] ............................................................................................. 13 GRANTS PENDING ................................................................................................................................................... 15 GRANTS COMPLETED ............................................................................................................................................ 16 PROFESSIONAL SOCIETY ACTIVITY .................................................................................................................. 25 PROFESSIONAL LISTINGS ..................................................................................................................................... 27 NON-PROFESSIONAL AFFILIATIONS .................................................................................................................. 27 "AVOCATIONS" ........................................................................................................................................................ 27 FOREIGN LANGUAGES........................................................................................................................................... 27 COMPUTER SKILLS ................................................................................................................................................. 27 BOOK CHAPTERS .................................................................................................................................................... 27 ARCHIVAL PEER-REVIEWED PUBLICATIONS (2004-pres)............................................................................... 28 ARCHIVAL PEER-REVIEWED PUBLICATIONS – Pre 2004 ................................................................................ 33 Refereed Conference Proceedings – (2004-pres) ........................................................................................................ 36 Non-Refereed Presentations and Conference Proceedings (2004-pres) ...................................................................... 40 CONFERENCE PROCEEDINGS AND PRESENTATIONS (pre-2004, unsorted) ................................................... 46 SUMMARY OF INVITED PRESENTATIONS & SEMINARS (overlap with lists above) ...................................... 56 WORKSHOP AND CONFERENCE ORGANIZATION ........................................................................................... 59 SCIENTIFIC SESSIONS CHAIRED AND INVITED PANELS ............................................................................... 59 DISSCUSSIONS OR REVIEWS (PRESS COVERAGE) .......................................................................................... 60 OTHER 61