Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME

POSITION TITLE

Matthew O'Donnell

Frank & Julie Jungers Dean of Engineering

eRA COMMONS USER NAME

odonnel EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE (if applicable)

INSTITUTION AND LOCATION

University of Notre Dame, Notre Dame, IN University of Notre Dame, Notre Dame, IN

B.S. Ph.D.

YEAR(s)

1972 1976

FIELD OF STUDY

Physics Physics

A. Positions and Honors Professional Experience: 1972-1976 Graduate Research & Teaching Fellow in Physics, University of Notre Dame, Notre Dame, IN 1976-1978 Postdoctoral Fellow in Physics, Washington University, St. Louis, MO 1978-1980 Senior Research Associate in Physics and Research Instructor in Medicine, Washington University, St. Louis, MO 1984-1985 Research Fellow in Electrical Engineering, Yale University, New Haven, CT 1980-1990 Physicist, Corporate Research and Development Center, General Electric Company, Schenectady, NY 1990-2006 Professor, Electrical Engineering and Computer Science Dept., University of Michigan, Ann Arbor, MI 1998-2006 Professor and Chair, Biomedical Engineering Dept., University of Michigan, Ann Arbor, MI 1998-2006 Jerry W. and Carol L. Levin Professor of Engineering, University of Michigan, Ann Arbor, MI 2006-present Frank & Julie Jungers Dean of Engineering, University of Washington, Seattle, WA 2006-present Professor, Bioengineering Department, University of Washington, Seattle, WA Honors and Awards: B.S. with Honors, Notre Dame, 1972; Best Paper Award, Medical Physics, 1984; Best Paper Award, Medical Physics, 1985; Whitney Award 1990, Internal GE Research Award; Whitney Award 1991; Teaching Awards: EECS Dept. - 1995, College of Engineering – 1996, Univ. of Mich.; Research Award, BME Dept., Univ. of Mich., 1997; Achievement Award, IEEE Ultrasonics, Ferroelectric, and Frequency Control Society, 2007; Distinguished Alumni Award, University of Notre Dame, 2009; IEEE, Fellow; AIMBE, Fellow; National Academy of Engineering, Member B. Selected Peer-Review Publications Most Recent Archival Publications (2009): D.N. Stephens, M. O’Donnell, K.E. Thomenius, A. Dentinger, D. Wildes, P. Chen, K.K. Shung, J. Cannata, P.T. Khuri-Yakub, O. Oralkan, A. Mahajan, K. Shivkumar, and D. J. Sahn, “Experimental Studies with a Nine French Forward-Looking Intracardiac Imaging and Ablation Catheter,” Journal of Ultrasound in Medicine 28, pp. 207-215 (2009). R. Olafsson, R.S. Witte, C. Jia, S.W. Huang, K. Kim, and M. O’Donnell, “Cardiac Activation Mapping using Ultrasound Current Source Density Imaging (UCSDI),” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 3, pp. 565-574 (2009). S. Ashkenazi, Y. Hou, S-W Huang, T. Buma, and M. O’Donnell, “High Frequency Optoacoustic Transducers for Ultrasonic and Photoacoustic Imaging,” Photoacoustic Imaging and Spectroscopy, Optical Science and Engineering 143 (Chapter 18), CRC Press, ISBN 978-1-4200-5991-5, pp. 223-238 (2009). S.Y. Emelianov, Pai-Chi Li, and M. O’Donnell, “Photoacoustics for Molecular Imaging and Therapy,” Physics Today 62, no. 5, pp. 34-39 (2009).

PHS 398/2590 (Rev. 09/04)

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Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

Y. Petrank, L. Huang, and M. O’Donnell, “Reduced Peak Hopping Artifacts in Ultrasonic Strain Estimation Using the Viterbi Algorithm,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 7, pp. 1359-1367 (2009). L. Huang, Y. Petrank, S.W. Huang, C. Jia, and M. O'Donnell, “Phase Rotation Methods In Filtering Correlation Coefficients For Ultrasound Speckle Tracking,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 7, pp. 1368-1382 (2009). S. W. Huang, J.F. Eary, C. Jia, L. Huang, S. Ashkenazi, and M. O’Donnell, “Differential-Absorption Photoacoustic Imaging for Contrast Enhancement,” Optics Letters 34, no. 16, pp. 2393-2395 (2009). Other Publications(selected from over 325): M. O'Donnell, J.T. Wang, and H.A. Blackstead, "Magnetoelastic excitations in single crystal gadolinium", Phys. Rev. Letters 36, pp. 606 (1976). M. O'Donnell, E.T. Jaynes and J.G. Miller, "General relationships between ultrasonic attenuation and dispersion", J. Acoust. Soc. Am. 63, pp. 1935 (1978). M. O'Donnell, "NMR Blood Flow Imaging Using Multi-Echo, Phase Contrast Sequences", Med. Phys. 12 59-64 (1985). S.W. Flax and M. O'Donnell, "Phase Aberration Correction in Medical Ultrasound: Basic Principles", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control UFFC-35, pp. 758-767 (1988). M. O'Donnell, A.R. Skovoroda, B.M. Shapo and S.Y. Emelianov, "Internal displacement and strain imaging using ultrasonic speckle tracking," IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control UFFC-41, pp. 314-325 (1994). M. Karaman and M. O’Donnell, “Subaperture Processing for Ultrasonic Imaging”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control UFFC-45, pp. 126-135 (1998). K.W. Hollman, S.Y. Emelianov, J.H. Neiss, G. Joytan, G.J.R. Spooner, T. Juhasz, R.M. Kurtz, and M. O’Donnell, “Strain Imaging of Corneal Tissue with an Ultrasound Elasticity Microscope”, Cornea 21, pp. 6873 (2002). W.F. Weitzel, K. Kim, J.M. Rubin, R.C. Wiggins, H. Xie, X. Chen, S.Y. Emelianov, M. O’Donnell “Feasibility of Applying Ultrasound Strain Imaging to Detect Renal Transplant Chronic Allograft Nephropathy”, Kidney International 65, pp. 733-736 (2004). K. Kim, A. Agarwal, S-W Huang, M.F. Denny, M.J. Kaplan, S. Ashkenazi, M. O’Donnell, and N.A. Kotov, “Photoacoustic Imaging of Early Inflammatory Response Using Gold Nanorods,” Applied Physics Letters 90, Article # 223901 – 3 pages (2007). S.-W. Huang, S.-L. Chen, T. Ling, A. Maxwell, M. O’Donnell, L.J. Guo, and S. Ashkenazi, “Low-noise Wideband Ultrasound Detection Using Polymer Microring Resonators,” Applied Physics Letters 92, Article # 193509 – 3 pages (2008). R. Olafsson, R.S. Witte, S-W Huang and M. O’Donnell, “Ultrasound Current Source Density Imaging,” IEEE Transactions on Biomedical Engineering 55, pp. 1840-1848 (2008). D.N. Stephens, J. Cannata, R. Liu, J. Zhao, K. K. Shung, H. Nguyen, R. Chia, A. Dentinger, D. Wildes, K.E. Thomenius, A. Mahajan, K. Shivkumar, K. Kim, M. O’Donnell, A. Nikoozadeh, O. Oralkan, P.T. KhuriYakub, and D. J. Sahn, “Multifunctional Catheters Combining Intracardiac Ultrasound Imaging and Electrophysiologiy Sensing,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 55, no. 7, pp. 1570-1581 (2008). Y. Hou, J.-S. Kim, S. W. Huang, S. Ashkenazi, L.J. Guo, and M. O’Donnell, “Characterization of a Broadband All-Optical Ultrasound Transducer – from Optical and Acoustical Properties to Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 55, no. 8, pp. 1867-1877 (2008). R.S. Witte, T. Hall, R. Olafsson, S-W Huang, and M. O’Donnell, “Inexpensive Acoustoelectric Hydrophone for Mapping High Intensity Ultrasonic Fields,” Journal of Applied Phyiscs 104, Article # 054701 – 3 pages (2008). S. W. Huang, Y. Hou, S. Ashkenazi, and M. O’Donnell, “High Resolution Ultrasonic Imaging Using an Etalon Detector Array,” Applied Physics Letters 93, Article # 113501 – 3 pages (2008). Patents (selected from 58): M. O’Donnell, "Coded Excitation for Transmission Dynamic Focusing of Vibratory Energy Beam", U.S. Patent # 5,014,712, issued 5/14/91. M. O’Donnell, “Method and System to Create and Acoustically Manipulate a Microbubble”, U.S. Patent # 7,549,985, issued 06/23/09. PHS 398/2590 (Rev. 09/04)

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Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

C. Research Support Ongoing Research Support RO1 HL082640 (Subcontract to Yale: P.I. James Duncan) NIH LV Strain Quantification for 4D Echocardiography Role: PI of subcontract

6/1/06-5/31/11

This is a Bioengineering Research Partnership (BRP) to explore new data acquisition and signal processing methods for real-time elasticity imaging of the heart using 4D echocardiographic RF data. RO1 HL067647 (Subcontract to OHSU: P.I. David Sahn) NIH High Frequency Ultrasound Arrays for Cardiac Imaging Role: PI of subcontract

9/1/08-8/31/13

This is a Bioengineering Research Partnership (BRP) to explore intracardiac catheters integrating ultrasound imaging and electrophyiological mapping and therapy.

Completed Research Support RO1 EB003455 (Matthew O’Donnell, PI) NIH Optoacoustic Transduction for High-Frequency Ultrasound Role: PI

7/1/05-6/30/09 – transferred 9/1/06

Explore integrated optoacoustic device for a guidewire imaging array. R21 EB003449 (Matthew O’Donnell, PI) NIH Ultrasonic Imaging of LIOB in Dendrimer Nanocomposites Role: PI

4/1/05-3/31/07 – transferred 9/1/06

Explore molecular imaging using dendrimer nanocomposites. R21 EB003451 (Matthew O’Donnell, PI) NIH Microwave Induced Thermal Imaging Role: PI

8/1/05-7/31/07 – transferred 9/1/06

Explore thermal strain imaging to differentiate water-bearing from lipid-bearing tissue. RO1 CA91713 (Subcontract, P.I. Paul Carson) NIH Combined Digital X-Ray and Ultrasound Breast Imaging Role: PI of subcontract

9/27/02-8/31/07 – transferred 9/1/06

This is a Bioengineering Research Partnership (BRP) to explore an integrated mammography and ultrasound system providing tissue elasticity information. T32 DE07057-26 (Paul Krebsbach, PI) NIH Tissue Engineering and Regeneration Role: Co-investigator

7/1/02-6/30/07 – transferred 9/1/06

Training grant in tissue engineering and regenerative medicine. PHS 398/2590 (Rev. 09/04)

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Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

1 R21 EB004933-01 (L. Jay Guo, PI) NIH Ultrasound Imaging Using Photonic Microring Resonators Role: Co-investigator

4/1/05-3/31/07– transferred 9/1/06

Explore novel integrated optical device for high frequency ultrasound imaging. 1 R21 EY015876-01 (Kyle Hollman, PI) NIH Bubble Based Acoustic Force Elasticity for Presbyopia Role: Co-investigator

4/1/05-3/31/07– transferred 9/1/06

Explore new technology to measure tissue elasticity by deforming tissue with acoustic radiation force applied to femtosecond laser produced microbubbles.

PHS 398/2590 (Rev. 09/04)

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SUZIE HWANG PUN Curriculum Vitae

University of Washington Foege Building, N530P Bioengineering, Box 355061 Seattle, WA 98195

Phone: 206-685-3488 Fax: 206-616-3928 Email: [email protected]

EDUCATIONAL HISTORY California Institute of Technology, Pasadena, California Ph.D. in Chemical Engineering with minor in Biology, December 2000 M.S. in Chemical Engineering, 1998 Advisor: Mark E. Davis “Rational Design of a New Class of Cyclodextrin-Containing Polymers for Gene Delivery” Stanford University, Stanford, California B.S. in Chemical Engineering, June 1996

EMPLOYMENT HISTORY University of Washington Seattle, Washington, USA Robert J. Rushmer Associate Prof. of Bioengineering and Associate Prof. of Chemical Eng., 2009-present Assistant Professor of Bioengineering and Adjunct Asst. Professor of Chemical Engineering, 2003-2009 Insert Therapeutics Pasadena, California, USA Senior Scientist, 2000-2003

AWARDS AND HONORS Robert F. Rushmer Term Professorship Undergraduate Mentor Award, University of Washington Junior Faculty Innovator Award, UW College of Engineering Outstanding Teacher/Mentor Award, UW Bioengineering Presidential Early Career Award for Scientists and Engineers (PECASE) Invited Chair, National Academies of Science Symposium on ChineseAmerican Frontiers of Science National Science Foundation CAREER Award Alliance for Cancer Gene Therapy Young Investigator Award National Hemophilia Foundation Career Development Award Invited Participant of National Academies/Keck Futures Conference Marian E. Smith Jr. Faculty Research Award, University of Washington MIT Technology Review’s TR100 Award: “top 100 young innovators” Everhart Lectureship Prize,California Institute of Technology Constantin G. Economou Memorial Lectureship Prize, Caltech Whitaker Foundation Doctoral Fellow President’s Award, Stanford University

2009 2008 2008 2007 2006 2006 2005 2005 2004 2004 2004 2002 2000 1998 1996-2000 1993

Dr. Suzie H. Pun Curriculum Vitae 01/20/2010

RECENT REFEREED PUBLICATIONS (2008-2010) 1. Rodriguez, V.,* Henry, S.,* Hoffman, A.S., Stayton, P.S., Li, X., and Pun, S.H. (2008) Polymeric micelle encapsulation of indocyanine green. Journal of Biomedical Optics, 13(1), Article 014025. 2. Bergen, J.M., Park, I.K., Horner, P.J., and Pun, S.H. (2008) Nonviral approaches for neuronal delivery of nucleic acids. Pharmaceutical Research, 25(5):983-998. 3. Saul, J.M.,* Wang, C.K.,* Ng, C.P., and Pun, S.H. (2008) Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery Advanced Materials, 20(1):19-25. 4. Bergen, J.M. and Pun, S.H. (2008) Analysis of intracellular barriers encountered by non-viral gene carriers in a model of spatially-controlled delivery to neurons. Journal of Gene Medicine 10(2):187-197. 5. Bergen, J.M., Kwon, E.J., Shen, T.W., and Pun, S.H. (2008) Application of an environmentallysensitive fluorophore for rapid analysis of the binding and internalization of gene carriers. Bioconjugate Chemistry 19(1):377-384. 6. Ng, C.P. and Pun, S.H. (2008) A versatile 3-D soft tissue perfusion chamber for mimicking tissue microenvironments. Biotechnology and Bioengineering 99(6):1490-1501. 7. Park, I.K., Ng, C.P., Wang, J., Chu, B.C., Wang, C., Zhang, S.R., and Pun, S.H. (2008) Determination of nanoparticle vehicle unpackaging by MR imaging of a T2 magnetic relaxation switch. Biomaterials 29(6): 724-732. 8. Burke, R.S. and Pun, S.H. (2008) Extracellular barriers to in vivo PEI and PEGylated PEI polyplexmediated gene delivery to liver. Bioconjugate Chemistry 19(3):693-704. 9. Kwon, E.J., Bergen, J.M. and Pun, S.H. (2008) Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconjugate Chemistry, 19(4):920-927. 10. Goodman, T.T., Chen, J., Matveev, K., and Pun, S.H. (2008) Spatio-temporal modeling of nanoparticle delivery to multicellular spheroids. Biotechnology and Bioengineering, 101(2):388-399. 11. Kwon, E.J., Bergen, J.M., Park, I.K., and Pun, S.H. (2008) Peptide-modified vectors for nucleic acid delivery to neurons. J Controlled Rel,132:230-235. 12. Goodman, T.T., Ng, C.P., and Pun, S.H. (2008) 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconj Chem, 19:1951-1959. (Invited review and cover article) 13. Miao, X. Wilson, B.K., Pun, S.H. and Lin, L.Y. (2008) Optical manipulation of micro/nano particles and biomolecules through plasmonics. Optics Express 16(18):13517-13525. 14. Ng, C.P., Goodman, T.T., Park, I.K. and Pun, S.H. (2009) Bio-mimetic surface engineering of plasmid-loaded nanoparticles for active intracellular trafficking by actin “comet tail” motility. Biomaterials, 30:951-958. 15. Miao, X., Wilson, B.K., Cao, G., Pun, S.H., and Lin, L.Y. (2009) Long-range trapping and rotation of nanowires and nanotubes by plasmonic tweezers. IEEE Journal of Selected Topics in Quantum Electronics, 15(5):1515-1520. 16. Kwon, JS., Park, IK., Cho, AS., Shin, SM., Hong, MH., Jeong, SY, Kim, YS., Min, JJ., Kim, WJ., Jo, SB., Pun, SH., Cho, JG., Park, JC., Kang, JC., and Ahn, YK. (2009) Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model. J Controlled Release, 138:168-176. 17. Burke, R.S. and Pun, S.H. (2010) Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery. Bioconjugate Chemistry, 21:140-150. 18. Kwon, E.J., Lasiene, J., Jacobson, B., Park, I.K., Horner, P.J., and Pun, S.H. (2010) Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials, 31:24172424. 19. Kim, T.H., Mount, C., Chen, Y., Gombotz, W., Pun, S.H., and Li, X. Evaluation of temperaturesensitive, indocyanine green-encapsulating micelles for near-infrared imaging. Submitted.

2

CURRICULUM VITAE Paul J. Campagnola Department of Cell Biology and Center for Cell Analysis and Modeling University of Connecticut Health Center Farmington, CT 06030 USA Tel:1-860-679-4354 FAX:1-860-679-10340 email:[email protected] 1. Personal Information Birth: Auburn, NY, UYSA 1964 2. Education and Training (in chronological order) 1992. Physical Chemistry, Yale University, PhD 1986 Chemistry, Colgate University, BA 3. Professional Experience 2010.7~ Biomedical Engineering Department, University of Wisconsin, Madison, Associate Professor 2010.7~ Medical Physics Department, University of Wisconsin, Madison, Associate Professor 2009.7~ Biomedical Engineering Department, University of Wisconsin, Madison, Visiting Associate Professor 2003.7~ Cell Biology Department, University of Connecticut Health Center, Assistant Professor (tenure track) 1998.7~ Cell Biology Department, University of Connecticut Health Center, Assistant Professor (in residence) 1995.9 Cell Biology Department, University of Connecticut Health Center, Instructor 1992.2 JILA, University of Colorado, Postdoctoral Associate 4. Fields of Specialty - Nonlinear optical biological microscopy - Nano/microfabrication for biological applications 5. List of selected recent publications (*corresponding author) S. Plotnikov, V. Juneja, A. Isaacson, W.A. Mohler, and P. J. Campagnola, Optical Clearing for Improved Contrast in Second Harmonic Generation Imaging of Skeletal Muscle, Biophys. J.,90, 328-339 (2006) S. Plotnikov, A.C. Millard, P.J. Campagnola, and W.A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres.” Biophys J., 90, 693-703, (2006). L.P. Cunningham, M.P. Veilleux, and P.J. Campagnola, “Freeform multiphoton excited microfabrication for biological applications using a rapid prototyping CAD-based approach”, Optics Express, 14, 86138621 (2006). R. LaComb, O. Nadiarnykh, S. Townsend, and P.J. Campagnola, “Phase Matching considerations in Second Harmonic Generation from tissues: Effects on emission directionality, conversion efficiency and observed morphology, Optics Comm, 281, 1823-1832 (2008). R. LaComb, O. Nadiarnykh, and P.J. Campagnola, “Second Harmonic Generation imaging of osteogenesis imperfecta: experiment and simulation”, Biophys. J., 94, 4504-4514 (2008). R. LaComb, O. Nadiarnykh, S. Carey and P.J. Campagnola, “Quantitative SHG imaging and modeling of the optical clearing mechanism in striated muscle and tendon” J. Biomed Opt. 13, 021108 (2008). X. Chen, M.A. Brewer,C. Zou and P.J. Campagnola, Migration and adhesion of ovarian cancer cells on crosslinked laminin fibers nanofabricated by multiphoton excited photochemistry, Integrative Biology, 1, 469 – 476 (2009). O. Nadiarnykh and P. J. Campagnola, Retention of polarization signatures in SHG microscopy of scattering tissues through optical clearing, Optics Express, 17, 5794-5806 (2009)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME

POSITION TITLE

Xiaohu Gao

Assistant professor

eRA COMMONS USER NAME (credential, e.g., agency login) EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

Georgia Institute of Technology and Emory University, Atlanta, GA

Postdoc fellow

2004-2005

Biomedical Engineering

Indiana University, Bloomington, IN

Ph.D.

1999-2004

Bioanalytical chemistry

A. Bio Prof. Xiaohu Gao received his Ph.D. degree in chemistry from Indiana University, Bloomington in 2004, and his postdoctoral training from the Department of Biomedical Engineering at Georgia Tech and Emory University. He became a faculty member in the Department of Bioengineering and the Center for Nanotechnology at the University of Washington, Seattle in 2005. His research is focused on biomedical nanotechnology, molecular engineering and molecular imaging. He has authored or co-authored over 40 papers and book chapters; and he is also a recipient of the NSF CAREER Award. He has been a member of the American Chemical Society (ACS) and Biomedical Engineering Society (BMES) since 2003. B. Positions and Honors Employment and Professional Experiences: 2010Editorial board member, new journal Probes, Landes Bioscience 2008Affiliated faculty of the Center for Ecogenetics and Environmental Health at UW 2006Assistant Editor of Nanoscale Research Letters, Springer 2005Assistant professor, Department of Bioengineering at UW 2005Faculty of the Center for Nanotechnology at UW, Seattle 2004-2005 Postdoctoral fellow, Department of Biomedical Engineering at Georgia Tech. and the Winship Cancer Institute at Emory University Honors: 2008 2007 2006 2006 2002-2003

National Academy of Engineering Frontiers of Engineering symposia invited speaker NSF Faculty Early Career Development (CAREER) award New investigator award in prostate cancer research, DOD-CDMRP Program Wallace H Coulter Translational Research award Bioplex postdoctoral fellow, Emory University

C. Representative Publications 1.

M.Y. Han, X Gao, J. Su, S. Nie, Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules, Nature Biotechnol. 2001, 19, 631-635.

2.

X. Gao, Y.Y. Cui, R.M. Levenson, L.W.K. Chung, S. Nie, In vivo cancer targeting and imaging with semiconductor quantum dots, Nature Biotechnol. 2004, 22, 969-976.

3.

Y. Jin and X. Gao, Plasmonic fluorescent quantum dots, Nature Nanotech. 2009, 4, 571-6.

CURRICULUM VITAE Dar-Bin Shieh (謝達斌) Institute of Oral Medicine, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6- 2353535 ext. 5410; Fax: +886-6- 2766626; E-mail: [email protected]

1. Educations 1997 1997 1988

Doctor of Medical Sciences (D.M.Sc) in Oral Biology, Harvard University, USA Certificate in Oral Diagnosis and Oral Pathology, Harvard School of Dental Medicine, USA. Doctor of Dental Surgery (D.D.S.), National Yang-Ming University, Taiwan.

2. Professional Experiences 2008.8~ 2007.2~ 2000.8~ 2005.10~2007.1 2005.8~2005.7 1997.7~1999.1

Institute of Oral Medicine, National Cheng Kung University, Professor Office of Research and Development, NCKU, Director of University Development NCKU Medical Center, Session Chair of Oral Diagnosis and General Dentistry Center for Micro-Nano Science and Technology, NCKU, Director of Research and Education Institute of Oral Medicine, National Cheng Kung University, Assistant Professor Dept. Experimental Medicine, Harvard Medical School, Research Fellow

3. Major awards and honors - Best Basic Science Award in 10th International Congress on Oral Cancer, Island of Crete, Greece, 2005 Apr. (WHO, ICOOC, HATMC, and HCS cosponsor) - Fellow, the International Academy of Oral Oncology (Since 2005) - Editorial Board, Journal of Taiwan Nanotechnology Industry Development Association (Since 2005) - Member of IEEE Technical Committee on Nano-Biomedicine (Since 2006) - Outstanding Teaching Award of National Cheng Kung University (2006) - Who’s Who in the World 2007, Marquis Who’s Who, USA - Member of Advisory Board, 2007 International Conference on Bionano Sciences, Taiwan (2007 ICONBS, Taiwan) - Schering Scholar Award from the American Beraue for Medical Advancement in China (ABMAC, 1985)

4. List of Recent Selected Publications (* corresponding author) - Chang HJ, Wu CM, Chang YC, Fanchiang JC, Shieh DB*, Wong TY. Collagen enhances biocompatibility and strength of glassionomer. Accepted by Journal of Dental Research. - Hwu JR, Lin YS, Josephrajan T, Hsu MH, Cheng FY, Yeh CS, Su WC, Shieh DB. Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles. Journal of the American Chemical Society, 131(1), 66-68, 2009 Jan. - Wu PC, Su CH, Cheng FY, Weng JC, Tsai TL,Yeh CS, Chen JH, Hwu JR, Tzeng Y, Su WC, Shieh DB*. Modularly Assembled Magnetite Nanoparticles Enhance in vivo Targeting for Magnetic Resonance Cancer Imaging. Bioconjugate Chemistry, 19 (10): 1972-1979, 2008 Oct. - Jeng YR, Lin TT, Wong TY, Chang HJ, Shieh DB*. Nano-mechanical properties of fluoride treated enamel surface. Journal of Dental Research, 87(4):381-385, 2008 Apr. - Li PC, Wang CRC, Shieh DB, Wei CW, Liao CK, Poe C, Jhan S, Ding AA, Wu YN. In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods. Optics Express, 16(23): 18605-18615, 2008 Nov. - Yang CY, Wei CW, Lin YP, Tseng HC, Wu YN, Chen CC, Shieh DB*, Li PC. Applications of Carbohydrate-Gold Nanoparticles for Volumetric Flow Measurements Using an Opto-Acoustic Technique. Journal of the Chinese Chemical Society, 55(1):103-108,2008 Feb. - Wu PC, Wang WS, Huang YT, Shen HS, Lo YW, Tsai TL, Shieh DB*, Yeh CS. Porous Iron Oxide-Based Nanorods Developed as Delivery Nanocapsules. Chemistry-A European Journal, 13(14): 3878-3885, 2007 May. - Shieh DB, Chen CC, Shih TS, Tai HM, Wei YH, Chang HY. Mitochondrial DNA alterations in blood of the humans exposed to N, N-Dimethylformamide. Chemico-Biological Interactions, 165(3): 211-219, 2007 Feb. - Tai SP, Wu YN, Shieh DB, Chen LJ, Lin KJ, Yu CH, Chu SW, Chang CH, Shi XY, Wen YC, Lin KH, Liu TM, Sun CK. Molecular Imaging of Cancer Cells Using Plasmon-Resonant-Enhanced Third-Harmonic-Generation in Silver Nanoparticles. Advanced Materials, 19(24): 4520-4523, 2007 Dec. - Lin MC, Chu CJ, Tsai LC, Lin HY, Wu CS, Wu YP, Wu YN, Shieh DB, Su YW, Chen CD. Control and detection of organosilane polarization on nanowire field-effect-transistors. Nano Letters, 7(12): 3656- 3661, 2007 Dec. - Su CH, Sheu HS, Lin CY, Huang CC, Lo YW, Pu YC, Weng JC, Shieh DB, Chen JH, Yeh CS. Nanoshell Magnetic Resonance Imaging Contrast Agents. Journal of the American Chemical Society, 129(7): 2139-2146, 2007 Feb. - Hsu MH, Josephrajan T, Yeh CS, Shieh DB, Su WC, Hwu JR. Novel arylhydrazone-conjugated gold nanoparticles with DNA-Cleaving ability: The first DNA-Nicking nanomaterial. Bioconjugate Chemistry, 18 (6): 1709-1712, 2007 Nov-Dec. - Li PC, Wei CW, Liao CK, Chen CD, Pao KC, Wang CRC, Wu YN, Shieh DB. Photoacoustic imaging of multiple targets using gold nanorods. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, 54 (8): 1642-1647, 2007 Aug. - Shieh DB*, Su CH, Chang FY, Wu YN, Su WC, Hwu JR, Chen JH, Yeh CS. Aqueous nickel- nitrilotriacetate modified Fe3O4–NH3+ nanoparticles for protein purification and cell targeting. Nanotechnology, 17(16): 4174-4182, 2006 Aug.

- Shieh DB, Chen IW, Shiao CY, Wei CY, Chung CH, Chang HJ, Jin YT, Wong TY. Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications. Oral Oncology, 42(6):599-606, 2006 Jul. - Hsiao MT, Chen SF, Shieh DB*, Yeh CS. One-Pot Synthesis of Hollow Au3Cu1 Spherical-Like and Biomineral Botallackite Cu2(OH)3Cl Flower- Like Architectures Exhibiting Anti-microbial Activity. Journal of Physical Chemistry B, 110(1): 205-210, 2006 Jan. - Yang WH, Lee CF, Tang HY, Shieh DB, Yeh CS. Iron Oxide Nanopropellers Prepared by a Low-Temperature Solution Approach. J. of Physical Chemistry B, 110(29): 14087-14091, 2006 Jul. - Tai SP, Lee WJ, Shieh DB, Wu PC, Huang HY, Yu CH, Sun CK. In vivo optical biopsy of hamster oral cavity with epi-third-harmonic-generation microscopy, Optics Express, 14(13): 6178-6187, 2006 Jun. (Impact Factor: 3.709; ranking: 2/64) - Shieh DB, Yang SR, Shi XY, Wu YN, Wu SN. Properties of BKca Channels in Oral Keratinocytes. Journal of Dental Research, 84(5):468-473, 2005 May. - Shieh DB*, Chang FY, Su CH, Yeh CS, Wu MT, Tsai CY, Wu CL, Chen DH, Chou CH. Aqueous Dispersions of Magnetite Nanoparticles with NH3+-surfaces for magnetic manipulations of biomocules and MRI contrast agents. Biomaterials, 26(34): 7183-7191, 2005 Dec. - Chang FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB*. Characterization of a newly synthesized Fe3O4 nanoparticle aqueous dispersions and its biomedical applications. Biomaterials, 26: 729-738, 2005 Mar. - Chang YC, Shieh DB*, Chang CH, Chen DH. Conjugation of Monodisperse Chitosan-bound Magnetic Nano-carrier with Epirubicin for Targeted Cancer Therapy. Journal of Biomedical Nanotechnology, 1(2): 196-201, 2005. - Shieh DB*, Chou WB, Wei YH, Wong TY, Jin YT (2004). Mitochondrial DNA 4977 bp deletion in paired oral cancer and precancerous lesions revealed by lasermicrodissection and real-time quantitative PCR. Annals of the New York Academy of Sciences (Mitochondrial Pathogenesis: from Genes and Apoptosis to Aging and Disease), 1011: 154-167, 2004. - Tsai CY, Shiau AL, Cheng PC, Shieh DB, Chen DH, Chou CH, Yeh CS, Wu CL. A biological strategy for fabrication of Au:EGFP nanoparticle conjugates retaining bioactivity. Nano Letters, 4(7): 1209-1212, 2004. - Jen CP, Chen YH, Fan CS, Yeh CS, Lin YC, Shieh DB, Wu CL, Chen DH, Chou CH. A Nonviral Transfection Approach in Vitro: The Design of a Gold Nanoparticle Vector Joint with Microelectro-mechanical Systems. Langmuir, 20(4): 1369-1374, 2004. - Shieh DB, Godleski J, Herndon JE II, Azuma T, Mercer H, Sugarbaker DJ, Kwiatkowski DJ. Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. Cancer, 85(1): 47-57, 1999. - Kwiatkowski DJ, Harpole DH Jr., Godleski J, Herndon JE II, Shieh DB, Richards W, Blanco R, Xu HJ, Strauss GM, Sugarbaker DJ. Molecular pathologic substaging in 244 stage I non-small- cell lung cancer patients: clinical implications. Journal of Clinical Oncology, 16(7): 2468-77, 1998.

CURRICULUM VITAE Jia-Jin Jason Chen (陳家進) Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan E-mail:[email protected] 1. Personal Information Born: Sept 6th, 1958 2. Education: B. S., Biomedical Engineering, Chung Yuan Christian University, 1980 M. S., Biomedical Engineering, Vanderbilt University, TN, USA 1987 Ph.D., Biomedical Engineering, Vanderbilt University, TN, USA 1990 3. Professional Experience: Visiting Scientist, U. of Cape Town, South Africa 1991 Visiting Scientist, Neuroscience Division, U. of Alberta, Canada 1998 Honorary Professor, U. of Otago, New Zealand 2004-2005 Director, Institute of Biomedical Engineering, NCKU Since 2009/8 Distinguished Professor, Institute of Biomedical Engineering, Since 2007 Professor, Institute of Biomedical Engineering, Since 1997 4. Service and honors: - Executive Editor-in-Chief, Journal of Medical and Biological Engineering (an SCIE journal) - Member of NHRI extramural research committee - Committee member of Department of Industrial Technology for medical device section 5. Research Interest: Neural Engineering, Biomedical Engineering, Neural Interface, Integration of cortical interface with neural prostheses, optoelectrical stimulation/sensing 6. List of Recent Selected Publications: -

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Shu-Ping Lin, Themis R. Kyriakides, Jia-Jin J. Chen “Characterization of a three-dimensional matrix on microelectrode arrays for on-line cell growth observation,” Biomaterials, 2009. Pei-Yi Lin, Sang-I Lin, Trevor Penney, Jia-Jin Chen, “Review: Applications of Near Infrared Spectroscopy and Imaging for Motor Rehabilitation in Stroke Patients,” Journal of Medical and Biological Engineering, 29(5):210-221, 2009. Yi-Ning Wu, Jia-Jin Jason Chen, Li-Qun Zhang, Brian I. Hyland, “Regulation of hind-limb tone by adenosine A2A receptor in rats,” Neuroscience, vol. 159, no. 4, pp. 1408-1413 2009.

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Chih-Wei Peng, Jia-Jin Jason Chen, Chen-Li Cheng, and Warren M. Grill*, “Role of pudendal afferents in voiding efficiency in the rat,” American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 294: R660-R672, 2008.

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Shu-Ping Lin, Jia-Jin Jason Chen*, Jiunn-Der Liao, Shun-Fen Tzeng, “Characterization of surface modification on microelectrode arrays for in-vitro cell culture,” Biomedical Microdevices, vol. 10, no.

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1, 99-111, 2008. Chih-Wei Peng, Jia-Jin Jason Chen, Chen-Li Cheng, and Warren M. Grill*, “Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents,” Journal of Neural Engineering, vol. 5, 144-154, 2008 . 1

Penn Biographies Britton Chance (born 1913) • •

• •

B.S. 1935, Ph.D. 1940, Sc.D. (hon.) 1985 Member of Alpha Chi Sigma, Tau Beta Pi and Sigma Tau scientific honorary societies Professor of Biophysics and Physical Chemistry Director of the E.R. Johnson Foundation

• Member of the U.S. yachting team that won Olympic gold in 1952 • Member of the National Academy of Science • Pioneering researcher in biomedical optics and other fields

Britton Chance was born in Wilkes-Barre, Pennsylvania, in 1913. He spent the summers of his youth sailing and fishing in Antilles and the Panama Canal Zone. While still a teenager, his enthusiasm for sailing led to his invention of an autosteering device that detected any deviation of a ship from its course and then provided a signal to correct the ship's steering. Britton Chance spent his college years at the University of Pennsylvania, earning his BS degree in 1935 and then remaining for his graduate work. While an undergraduate, Chance was a member of Alpha Chi Sigma, Tau Beta Pi and Sigma Tau - all professional and honorary societies in engineering and chemistry. As a graduate student at Penn, Chance developed a microflow version of a stop-flow apparatus to study enzymes and their changing compositions in their reaction kinetics. In 1938, during his

graduate school years, he received a contract from the British General Electric Company to test his autosteering device on a ship traveling from London to New Zealand and Australia. While in London he met Glenn Millikan, who had developed an innovative stop-flow apparatus at Cambridge University, and became his research student. With the onset of World War II, Chance returned to the University of Pennsylvania to continue his research. Eventually Chance earned two Ph.D. degrees, one in physical chemistry from Penn in 1940 and another in biology and physiology from Cambridge University in 1942. Britton Chance first became a member of the Penn faculty in 1941 when he was appointed Assistant Professor of Biophysics and Physical Biochemistry in the School of Medicine. After World War II, Chance traveled to Stockholm on a Guggenheim Fellowship to work for two years with scientist Hugo Theorell before returning to the University of Pennsylvania. Chance continued at Penn as Professor of Biophysics and Physical Biochemistry from 1949 until 1983; he was also the Director of the E.R. Johnson Foundation in the School of Medicine for this entire period. Since 1983 he has continued at the University as a very active emeritus professor. In 1995 he was appointed President of the Medical Diagnostic Research Foundation (MDRF) in Philadelphia. Britton Chance has made important contributions not only in the identification of and functioning of enzyme-substrate compounds, but also in such varied areas of magnetic resonance spectroscopy in humans, the mathematics of the inverse problem, rf electronics, light transport in highly scattering media, breast cancer diagnostics, and muscle dynamics. His pioneering research has transformed the field of biomedical optics, including his efforts to develop spectroscopy as a noninvasive analytical tool for clinical diagnosis. He was elected to the National Academy of Science in 1954;his many honors include the Pennsylvania Award for Excellence (Life Sciences) in 1968, the National Medal of Science in 1974, and the Benjamin Franklin Medal for Distinguished Achievement in the Sciences, from the American Philosophical Society, in 1990. The Stellar-Chance Laboratories at the University of Pennsylvania, dedicated in 1995, are named after him.

Chance continued his love of sailing in his adult life. His skill and his competitive spirit earned him a spot on the U.S. sailing team at the 1952 Helsinki Olympics; he won an Olympic gold medal when his 31-foot sailboat, the Complex II (named after an elusive compound in an enzyme reaction), won three of its seven races. His lifelong interest in athletics encouraged him to later develop a device that improved the performance of athletes by monitoring chemical changes in their muscles.

CURRICULUM VITAE Pau-Choo Chung (詹寶珠) Department of Electrical Engineering, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6-2757575 ext. 623731; Fax: +886-6-2345482; E-mail: [email protected]

1. Personal Information Birth: Taipei, Taiwan, 1959.

2. Educations 1991 1983 1981

Electrical Engineering, Texas Tech University, Ph.D. Electrical Engineering, National Cheng Kung University, M.S. Electrical Engineering, National Cheng Kung University, B.S.

3. Professional Experiences 2008~ 2008~ 2005~

Institute of Computer and Communication Engineering, National Cheng Kung University, Director Department of Electrical Engineering, National Cheng Kung University, Vice Chairman Department of Electrical Engineering, National Cheng Kung University, Distinguished

2005~2008 2005~2008

Professor Electrical Laboratories, National Cheng Kung University, Director Center for Research of E-life Digital Technology, National Cheng Kung University, Director

2000~2005 1996~ 1991~1996 1987~1991 1983~1986

Center for Research of E-life Digital Technology, National Cheng Kung University, Vice Director Department of Electrical Engineering, National Cheng Kung University, Professor Department of Electrical Engineering, National Cheng Kung University, Associate Professor Department of Electrical Engineering, Texas Tech University, Research Assistant Chung-Shan Institute of Science & Technology, Research Assistant

4. Fields of Specialty - Neural Networks - Digital Image Processing - Medical Image Processing - Fuzzy System - Computer Vision 5. Major awards and honors -

IEEE Fellow for contributions to Neural Network Models for Biomedical Image Analyses, 2008. IEEE Distinguished Lecturer, Circuit and Systems Society, 2006~2007 First-Grade Excellence Research Award, National Science Council, Taiwan, 2005 Best Paper Award in Taiwanese Association for Artificial Intelligence, 2006 Annual Best Paper Award in Chinese Journal Radiology 2001 Best Paper Award in the 5th World multiconference on Systemics, Cybernetics, and Informatics, (SCI 2001) Florida, USA, 2001 Best Paper Award in the Conference of Computer Vision, Graphics, and Image Processing, Taiwan ROC, August, 2001 Best Research Young Innovator Award, National Science Council, 1999 Best Paper Award in Computer Vision, Graphics, and Image Processing Conference, Taiwan ROC, 1999 Best Paper Award in International Computer Symposium, Taiwan, December, 1998 Best Paper Award in Computer Vision, Graphics, and Image Processing Conference, Taiwan ROC, August, 1997 Best Paper Award in Computer Vision, Graphics, and Image Processing Conference, Taiwan ROC, 1996 Acer Dragon Award (Best Ph.D. Thesis Award), Acer Foundation, 1995 Acer Dragon Award (Excellence Master Thesis Award), Acer Foundation, 1994 Best Paper Award in Computer Vision, Graphics, and Image Processing Conference, Taiwan ROC, 1993 Excellence in Research Award of National Science Council, Taiwan, 1992~2000

6. List of Recent Selected Publications - Pau-Choo Chung, Chin-De Liu, “A daily behavior enabled hidden Markov model for human behavior understanding＂, Pattern Recognition, vol. 41, 1589-1597, 2008 - Chun-Rong Huang, Pau-Choo Chung, Bor-Shyang Sheu, Hsiu-Jui Kuo, and MikulᚠPopper, “Helicobacter pylori Related Gastric Histology Classification Using Support Vector Machine Based Feature Selection,＂ Accepted and to appear in IEEE Transactions on Information Technology in Biomedicine, 2008. - Sheng-Chih Yang, Chuin-MuWang, Hsian-He Hsu, Pau-Choo Chung*, Giu-Cheng Hsu, Chun-Jung Juan, Chien-Shun Lo, “Contrast enhancement and tissues classification of breast MRI using Kalman filter-based linear mixing method＂, Computerized Medical Imaging and Graphics, accepted. - Chun-Rong Huang, Chu-Song Chen, and Pau-Choo Chung, “Contrast Context Histogram - An Efficient Discriminating Local Descriptor for Object Recognition and Image Matching＂, Pattern Recognition Vol. 41, pp 3071-3077, 2008. - Chieh-Ling Huang, Pau-Choo Chung, Ming-Hua Tsai, Yen-Kuang Yang and Yu-Chia Hsu, “Reliability Improvement for an RFID-based Psychiatric Patient Localization System ＂, Computer Communications, Vol. 31, Issue 10, pp. 2039- 2048, 2008. - Chieh-Ling Huang, E-Liang Chen, and Pau-Choo Chung “Fall Detection using Modular Neural Networks with Back-projected Optical Flow ＂, Biomedical Engineering - Applications, Basis and Communications, Vol. 19, No. 6, pp. 415–424, 2007. - Pau-Choo Chung, Chieh-Ling Huang and E-Liang Chen, “ A Region-based Selective Optical Flow Back-Projection for Genuine Motion Vector Estimation ＂, Pattern Recognition, Vol. 40, Issue 3, pp. 1066-1077, 2007. (SCI) - Jiann-Shu Lee, Yung-Ming Kuo, Pau-Choo Chung, E-Liang Chen, "Naked image detection based on adaptive and extensible skin color model", Pattern Recognition 40 (2007) 2261-2270 - Chin-De Liu, Pau-Choo Chung, Yi-Nung Chung and Monique Thonnat, “Understanding of Human Behaviors from Videos in Nursing Care Monitoring Systems＂, Journal of High Speed Network, Vol. 16, pp. 91-103, 2007.. (SCI) - Pau-Choo Chung, Chieh-Ling Huang and E-Liang Chen, “ A Region-based Selective Optical Flow Back-Projection for Genuine Motion Vector Estimation ＂, accepted for publication in Pattern Recognition, Volume 40, Issue 3 , March 2007, pp. 1066-1077 (SCI) - Chun-Rong Huang, Pau-Choo Chung, Tong-Yee Lee, Sheng-Chih Yang and San-Kan Lee, “Reconstruction and Rendering of Microcalcifications from Two Mammogram Views by Modified Projective Grid Space (MPGS)＂, Computerized Medical Imaging and Graphics, vol. 30, no. 2, pp. 123-133, 2006. (SCI) - Sheng-Chih Yang, Hsian-He Hsu, Giu-Cheng Hsu, Pau-Choo Chung, Shu-Mei Guo, Chien-Shen Lo, Ching-Wen Yang, San-Kan Lee, Chein-I Chang, “ 3-D Localization of Clustered Microcalcifications Using Cranio-Caudal and Medio-Lateral Oblique Views＂, Computerized Medical Imaging and Graphics, Vol. 29, pp. 521-532, 2005. (SCI 1.158) - Sheng-Chih Yang, Chuin-Mu Wang, Yi-Nung Chung, Giu-Cheng Hsu, San-Kan Lee, Pau-Choo Chung, Chein-I Chang, ＂A Computer-Aided System for Mass Detection and Classification in Digitized Mammograms＂, Biomedical Engineering Applications, Basis, and Communications, Vol. 17, No.5, pp. 215-228, 2005. (EI) - Pau-Choo Chung, Chin-Wen Wu, and Yen-Lang Huang, “A JPEG2000 Error Resilience Method Using Uneven Block-sized Information Included Markers,＂ IEEE Transactions on Circuits and Systems for Video Technology, Vol. 15, No.3, pp.420-424, March 2005. (SCI 1.942) - Lee WT, Chu KC, Chung KC, Pan JY, Chung PC, “Scheduling delay minimization for non-UGS data in multi-channel HFC network＂, IEICE TRANSACTIONS ON COMMUNICATIONS E88B (2): 623-631 FEB 2005 (SCI 0.436) - Chun-Rong Huang, Chu-Song Chen, and Pau-Choo Chung, “Tangible Photo-Realistic Virtual Museum,＂ IEEE Computer Graphics and Applications. Vol. 25, No.1, pp.15-17, 2005. (SCI 1.911) - Tsai-Rong Chang, Pau-Choo Chung, Tzai-Wen Chiu and Paul Wai-Fung Poon, "A new method for adjusting neural response jitter in the STRF obtained by spike-trigger averaging", Biosystems - Journal of Biological and Information Processing Science, Vol. 79, pp.213-222, January 2005. (SCI 0.971) - 楊勝智、詹寶珠、徐先和、鄭棕翰，「應用多頻譜影像處理技術於乳房核磁共振影像之組織分類」，影像與識別， Vol. 10, No.4, pp.24-36, 2004. - Chien-Cheng Lee, Pau-Choo Chung, Yunghsiang Sam Han, Dyi-Rong Duh, and C. W. Lin, “A Practice of a Collaborative Multipoint Medical Teleconsultation System on Broadband Network,＂ Journal of High Speed Networks - Chun-Rong Huang, Chu-Song Chen, and Pau-Choo Chung, “ An Improved Algorithm for Two-image Camera Self-Calibration and Euclidean Structure Recovery Using Absolute Quadric,＂ Pattern Recognition, vol. 37, no. 8, pp. 1713-1722, 2004. (SCI 1.611) - Chun-Rong Huang, Bor-Shyang Sheu, Pau-Choo Chung, and Hsiao-Bai Yang, “Computerized diagnosis of Helicobacter pylori infection and associated gastric inflammation from endoscopic images by refined feature selection using a neural network,＂ Endoscopy, vol. 36, pp. 1-8, 2004. (SCI 3.227) - Tsai-Rong Chang, E-Liang Chen, Paul Wai-Fung Poon, Pau-Choo Chung and Tzai-Wen Chiu, "Responses of central auditory neurons modeled with finite impulse response (FIR) neural networks," Computer Methods and Programs in Biomedicine, Vol. 74, pp.151-165, 2004. (SCI 0.724)

CURRICULUM VITAE Wen-Sheng Tzeng (曾文盛) Department of Medical Imaging, Chi-Mei Medical Center Tainan 701, Taiwan Tel: +886-6-2812811; E-mail: [email protected]

1. Educations 1990~1991

Chief Resident, Department of Radiology, Veterans General Hospital-Kaohsiung, Kaohsiung,

1987~1990

Residency, Department of Radiology, Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China Internship, Tri-Service General Hospital, Taipei, Taiwan, Republic of China School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

Taiwan, Republic of China 1985~1987 1980~1987

2. Professional Experiences 2008.7~ Assistant professor 2007.5~ Departmental Director, Department of Medical Imaging, Chi-Mei Medical Center 2004.6~ 2007.4 Departmental Director, Department of Diagnostic Radiology, Chi-Mei Medical Center 2008.10.24~10.28 12th Asian-Oceania Congress of Radiology SEOUL, Korea 2008.6.9~6.12 The 8th Asia-Pacific Congress of Cardiovascular and Interventional Radiology, Malaysia

2006.11.26~12.1 92nd Scientific Assembly and Annual Meeting, U.S.A. 2006.5.16~5.19 2006 EuroPCR, Paris 4. Fields of Specialty - Interventional Radiology - Abdominal Imaging 5. List of Recent Selected Publications (* corresponding author) - Su CK, Chen SS, Tzeng WS. Clinical application of defecography, Chinese J Radiol 1988; 13 : 371-377. - Wang JH, Lirng JH, Tzeng WS. Adrenal myelolipoma : case report and review of the literature, Chinese J Radiol 1989; 14 : 231-238. - Tzeng WS, Lee KR. Spin echo. In : Yang CF, et al ed. Diagnostic magnetic resonance imaging (Chinese edition), Taipei, Taiwan, Hwa-Rong Book Comp. 1990: 57-64. - Tzeng WS, Lee KR. Inversion recovery. In : Yang CF, et al ed.Diagnostic magnetic resonance imaging (Chinese edition),Taipei,Taiwan, Hwa-Rong Book Comp. 1990 : 65-73. - Tzeng WS, Ho YJ, Lee SK, Yang CF. Clinical application of percutaneous cholecystostomy, Chinese J Radiol 1991; 16 : 175-182 - Yu CC, Huang JK, Tzeng WS, Wu JD, Lee YH, Jiaan BP.Simultaneous bilateral adrenal metastases from reanl cell carcinoma : surgical implications and review of the literature, Eur Urol 1992; 22 : 335-338. - Wu TT, Lee YH, Tzeng WS, Chen WC, Yu CC, Huang JK. The role of C-reactive protein and erythrocyte sedimentation rate in the diagnosis of infected hydronephrosis and pyonephrosis, J Urol 1994;152 : 26-28. - Chang JM, Tzeng WS, Pan HB, Yang CF, Lai KH. Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma : A randomized controlled study, Cancer 1994; 74 : 2449-2453. - Yang CF, Tzeng WS, Chang JM, Liang HL, Huang JS, Pan HB, Lo GH, Cheng JS, Lai KH.Experiences with transjugular intrahepatic portosystemic shunts for gastroesophageal variceal bleeding, Chinese Med J (Taipei) 1996; 57 : 204-213. - Tzeng WS, Yang CF, Chang JM, Huang JS, Cheng BC, Cheng KK.Iliac artery percutaneous transluminal angioplasty (PTA) as an adjuvant for surgical treatment of advanced infrainguinal arterial occlusive disease, Chinese J Radiol 1996; 21 : 271-276. - Chang HT, Mok KT, Tzeng WS. Induction intraarterial chemotherapy for T4 breast cancer through an implantable Port-catheter system, Am J Oncol (CCT) 1997; 20 : 493-499. - Chou CK, Mak CW, Hou CC, Chang JM, Tzeng WS. CT of the mesenteric vascular anatomy, Abdominal Imaging 1997; 22: 477-482. - Chou CK, Mak CW, Lin MB, Tzeng WS, Chang JM. CT of agenesis and atrophy of the right hepatic lobe, Abdominal Imaging 1998; 23: 603-607. - Chen JJ, Su CJ, Shu CS, Lin CY, Yang SH, Hsu SI, Tsai TJ, Tzeng WS. Intracrainal metastasis of small hepatocellular carcinoma-one case report, J Internal Med Taiwan 1999; 10 : 22-26. - Chang JM, Tzeng WS, Tsai TC, Lu D. Macronodular tuberculosis of the gallbladder and liver Mimicking carcinoma of gallbladder with hepatic metastasis : a case report, Chinese J Radiol 1999; 24 : 249- 252. - Mak CW, Chang JM, Tzeng WS, Yeow KM, Chou CK, Hou CC. Wandering spleen: report of a case, J Med Ultrasound 1999; 6: 88-91. - Tzeng WS, Lin MP, Mak CW, Chang JM, Chiu AWH, Huang SKH. Adult Wilms’ tumor presenting with a - multicystic appearance: report of one case, Chinese J Radiol 2000; 25: 27-30. - Chou CK, Mak CW, Huang MC, Tzeng WS, Chang JM. Differentiation of obstructive from non-obstructive small bowel dilatation on CT, Eur J Radiol 2000; 35: 213-220. - Yang SH, Lee C, Lin CY, Chen JJ, Uen YH, Chou CK, Tzeng WS, Lin CN. Idiopathic retroperitoneal fibrosis producing

acute pancreatitis: a case report, J Internal Med Taiwan 2000; 11: 26-29. - Mak CW, Wu TC, Chou CK, Tzeng WS, Sia YL, Chang JM, Lin CN. Ultrasonographic appearance of an adenomatoid tumor in the epididymis: report of a case, J Med Ultrasound 2001; 9: 202-205. - Koay LB, Tzeng WS, Tseng TL, Sun CS, Tu CW. Sonographic diagnosis of intrahepatic portal-hepatic venous shunt associated with portal vein aneurysm: report of a case, J Med Ultrasound 2001; 9: 197-201. - Wang JC, Lin CH, Tzeng WS, Chiu AW. An unusual presentation of adrenal adenoma on Magnetic Resonance Images: case report, J Urol ROC 2002; 13: 68-71. - Chia-Hsiang Lin, Chun-Hao Chen, Wen-Sheng Tzeng, Bor-Chih Cheng, and Allen Wen-Hsiang Chiu. Migration of a Dislodged Tip of an Ultrasound Lithotripter Probe to the Pulmonary Artery: A Rare Complication of Percutaneous Nephrolithotomy, Urology 2003, 62: 1121-1122 - Chun-Hao Chen, Ying-Huel Lee, Wen-Sheng Tzeng, and Steven K Huan. A Patient with Urgency, Frequency and Low Serum C-reactive Protein Level, Postgraduate Medical Journal. On Progress. - Wen-Sheng Tzeng, Reng-Hong Wu, Jinn-Ming Chang, Lok-Beng Koay, and Ching-Yih Lin. Transarterial Embolization for Hemobilia Caused by Aneurysm of Hepatic Artery: Report of a Case, Chinese J. Radiology 2004, 29(3): 147-152 - Mak CW, Tzeng WS, Chou CK, Chen CY, Chang JM, and Tzeng CC. Leiomyoma Arising from the Tunica Albuginea of the Testis: Sonographic Findings, Journal of Clinical Ultrasound. 2004, 32(6): 309-311. - Hon-Mei Cheng, Sjen-Jung Shen, Chien-Wen Chou, Chwen –Yi Yang, Su-Yu Chen, Wen-Sheng Tzeng, and Allen W. Chiu. Characteristics of Adrenal Incidentalomas: 5-year Experience in Chi-Mei Medical Center, Journal of Internal Medicine of Taiwan. 2004, 15(3): 108-114. - Hock-Khian Wong, Hsing-Tao Kuo, Sun-Lung Tsai, Yih-Huei Uen, and Wen-Sheng Tzeng. Isolated Gastric Varices Due to Focal Splenic Vein Stenosis, J Formos Med Assoc. 2004; 103 (8): 640-643. - Wen-Sheng Tzeng, Reng-Hong Wu, Jinn-Ming Chang, Ching-Yih Lin, Lok-Beng Koay, Yih-Huei Uen, Yu-Feng Tian, Yaou Fong. Transcatheter arterial embolization for hemorrhage caused by injury of the hepatic artery, JGHR. 2005;186:491-498. - Reng-Hong Wu, Wen-Sheng Tzeng, Jinn-Ming Chang. Iodized Oil Embolization to Brain Following Transcatheter Arterial Embolization of Liver: A Case Report, Journal of Gastroenterology Hepatology. Accepted for Publication. - Min-Tsung Wang, Wen-Sheng Tzeng, Jinn-Ming Chang, and Chee-Wai Mak. CT and MR Imaging Manifestation of Adrenal Hemangioma: a Case Report, Chinese J. Radiology. 2004; 29(6): 371-375. - Min-Tsung Wang, Wen-Sheng Tzeng, Jinn-Ming Chang, and Chee-Wai Mak. Radiographic Features of Intrinsic Endometriosis: a case report, Chinese J. Radiology. Accepted for Publication. - Min-Tsung Wang, Tai-Ching Wu, Tsung-Chia Tsai, Tai-Youeng Chen, Wen-Sheng Tzeng and Jinn-Ming Chang. Magnetic Resonance Imaging of Intramedullary Epodermoid Cyst of Low Thoracic Spinal Cord: a case report, Chinese J. Radiology. Accepted for Publication. - Wen-Sheng Tzeng, Reng-Hong WU, Jinn-Ming Chang, Ching-Yih Lin, Lok-Beng Koay, Yih-Huei Uen, Yu-Feng Tian and Yaou Fong. Transcatheter arterial embolization for hemorrhage caused by injury of the hepatic artery, Journal of Gastroenterology Hepatology 2005; 20: 1062-1068. - Y. L. Hsu, P. L. Kuo, W. S. Tzeng, C. C. Lin. Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis, Food and Chemical Toxicology 2006; 44: 704-713. - Victor Chia-Hsiang Lin, Alex Chien-Hwa Liao, Li-Ching Chang, Wen-Sheng Tzeng. Percutaneous Wallstent Implantation to Rescue Failed Ureteropyelostomy for Massive Ureteral Necrosis after Renal Transplantation, Transplantation 2006; 81(11): 1605-1606. - Ching-Nan Hung,Wen-Sheng Tzeng,Yen-Ting Chen,Pei-Jarn Chen. Establishment of Computerized Cancer Registry real-time Statistical Analysis System, Chinese J. Radiology. 2006；31(1)：29-34. - CW Mak, CY Chen, WS Tzeng and C-F Li. Epidermoid cyst of the testis, Australasian Radiology.2007;51:B74-B76 - Mei-Chun Chou,Ming-Ting Wu,Chia-Hui Chen,Mei-Hua Lee,and Wen-Sheng Tzeng. Multidetector CT Findings of a Congenital Coronary Sinus Anomaly: a Report of Two Cases,Korean J. Radiol 9(Suppl)，July 2008 - Ionic Versus Nonionic Contrast Media Solvents Used with an Epirubicin-based Agent for Transarterial Chemoembolization of Hepatocellular Carcinoma, J Vasc Interv Radiol 2008；19：342-350. - Percutaneous Management of Extrahepatic Bile Duct Stones by Papillary Balloon Dilation and Pushing Using an Occlusion Balloon, Chinese J. Radiology. 2008；33(3)：115-122.

CV of Alex Jen Boeing-Johnson Chair Professor and Chair Department of Materials Science & Engineering, University of Washington, 302J Roberts Hall, Box 352120, Seattle, WA 98195-2120. E-mail: [email protected], (Tel): 206-543-2626, (Fax): 206-543-3100 Education, Honor, and Awards • Ph.D., Department of Chemistry, University of Pennsylvania, Philadelphia, 1984 • World Class University Professor, Korea University, Korea, 2009 • PMSE Fellow, The American Chemical Society, Polymeric Materials Science & Engineering, 2009 • Board of Directors, Washington Technology Center, Appointed by the Governor of Washington State, 2007 • Faculty of Research Innovator Award, College of Engineering, University of Washington, 2007 • OSA Fellow, 2008, The Optical Society of America, 2007 • ChangJiang Endowed Chair Professor, Wuhan University, Ministry of Education, China, 2007 • SPIE Fellow, The International Society of Optical Engineering, 2006 • AAAS Fellow, The American Association for the Advancement of Science, 2005 • Member of the Editorial Advisory Board, Chemistry of Materials, Journal of the Experimental Nanoscience • Member of Advisory Board, Institute of Chemistry, Academia Sinica, Taiwan, 2002• Member of Advisory Board, College of Arts & Sciences, National Chiao Tung University, Taiwan, 2009 • Boeing-Johnson Endowed Chair, University of Washington, 1999• Industrial Fellow (rank as full professor), Northwestern University, 1995-2000 • Founder’s Award, ROITech, 1995 • President’s Award, EniChem America, 1989 • Rohm & Hass Research Fellowship, Dept. of Chemistry, University of Pennsylvania, 1981 Professional Experience and Research Interests: 2006-persent Director, Institute of Advanced Materials and Technology, University of Washington 2007-present Chair, Materials Science & Engineering, University of Washington 2005-2007 Acting Chair, Materials Science & Engineering, University of Washington 2003-present Associate Director, NSF-funded Science & Technology Center 1999-persent Professor, University of Washington, Seattle, WA 1997-1999 Associate Professor, Northeastern University, Boston, MA 1995-1996 Vice President, ROITech, Monmouth Junction, NJ 1988-1994 Group Leader/Senior Scientist, EniChem America Inc., NJ 1984-1988 Research Scientist, Allied-Signal, NJ Research Interests: Research interest focused on utilizing molecular, polymeric, and biomacromolecular selfassembly to create ordered arrangement of organic and inorganic functional materials for photonics, opto-electronics, nanomedicine, and nanotechnology. Employ the “molecular engineering” approach to tailor size, shape, sequence, and functionality of organic/hybrid functional materials and explore their applications. Professional Societies and Publications: Member of the American Chemical Society, the Materials Research Society, the International

Society of Optical Engineering. Author or co-author of over 450 publications and over 200 invited technical presentations. Inventor or co-inventor of over 50 patents and invention disclosures. 10 recent publications selected from >450 papers: 1. “Development of New Conjugated Polymers with Donor-π-Bridge-Acceptor Side Chains for High Performance Solar Cells”, F. Huang, K-S. Chen, H-L. Yip, S. K. Hau, O. Acton, Y. Zhang, J. D. Luo, and A. K-Y. Jen, J. Am. Chem. Soc., 2009, 131, 13886. 2. “A Simple and Effective Way to Achieve Highly Efficient and Thermally Stable BulkHeterojunction Polymer Solar Cells Using Amorphous Fullerene Derivatives as Electron Acceptor”, Y. Zhang, H-L. Yip, O. Acton, S. Hau, F. Huang, and A. K.-Y. Jen, Chem. Mater., 2009, 21, 2598. 3. “Highly Efficient White Polymer Light-Emitting Diodes Based on Lithium Salts Doped Electron Transporting Layer”, F. Huang, P.-I. Shih, C.-F. Shu, Y. Chi and A. K-Y. Jen, Adv. Mater., 2009, 21, 361. 4. “Polymer Solar Cells using Self-Assembled Monolayers Modified ZnO/Metals as Cathodes”, H-L. Yip, S. K. Hau, N-S. Baek, H. Ma, A. K.-Y. Jen, Adv. Mater., 2008, 20(12), 2376. 5. “π-σ-Phosphonic Acid Organic Monolayer/High-k Metal Oxide Hybrid Dielectrics for LowVoltage Organic Transistors”, O. Acton, G. Ting, H. Ma, J. W. Ka, H. L. Yip, N. M. Tucker, and A. K-Y. Jen, Adv. Mater., 2008, 20(19), 3697. 6. “Terahertz All-Optical Modulator in Silicon”, M. Hochberg, T. Bachr-Jones, G. Wang, J. Parker, K. Harvard, J. D. Luo, Z. Shi, P. Sullivan, A. K-Y. Jen, L. Dalton, and A. Scherer, Nature Materials, 2006, 5(9), 703. 7. “Record Electro-optic Coefficient of 170 pm/V and V of 1V at 1.55 µm in Hybrid Crosslinkable Polymer/Sol-gel Waveguide Modulators”, Y. Enami, C. T. DeRose, D. Mathine, C. Loychik, C. Greenlee, R. A. Norwood, T. D. Kim, J. Luo, Y. Tian, A. K-Y. Jen, and N. Peyghambarian, Nature Photonics, 2007, 1, 180. 8. “Ultra-Large and Thermally Stable Electro-Optic Activities from Supramolecular SelfAssembled Molecular Glasses”, T. D. Kim, J. W. Kang, J. D. Luo, S. H. Jang, J. W. Ka, S. Hau, Z. Shi, N. M. Tucker, T. Gray, R. M. Overney, J. B. Benedict, and A. K-Y. Jen, J. Am. Chem. Soc, 2007, 129, 488. 9. “Directed Assembly of Single-Walled Carbon Nanotubes via Drop-Casting onto a UVPatterned Photosensitive Monolayer”, J. A. Bardecker, A. Afzali, G. S. Tulevski, T. Graham, J. B. Hannon, and A. K-Y. Jen, J. Am. Chem. Soc., 2008, 130(23), 7226. 10. “Patterning of Robust Self-Assembled n-type Hexaazatrinaphthylene-based Nanorods and Nanowires by Microcontact Printing”, H.-L. Yip, J. Zhou, H. Ma, Y. Tian, N. M. Tucker, and A. K.-Y. Jen, J. Am. Chem. Soc., 2006, 128, 13042. π

Collaborators: A. Heeger, G. Bazan (UCSB), T. Marks, M. Ratner, S. Ho (Northwestern), M. Hayden (UMBC), T. Swager, F. Stellachi (MIT), S. R. Marder, J. Perry, B. Kippelen, J. Bredas (GIT), N. Armstrong, N. Peyghambarian, (U. of Arizona), G. Stegeman (CREOL), R. Chen (U. of Texas, Austin), L. Loo (Princeton), L. Dalton, M. Hochberg, S. Jenekhe, D. Ginger, C. Luscombe, M. Sarikaya, F. Ohuchi, D. Schwartz, F. Barneyx, R. Overney, M. Lidstrom, (U. of Washington), W. Steier (USC), R. Twieg (Kent State), Y. Yang, H. Fetterman (UCLA), A. Yariv, A. Scherer (Caltech), P. Goplan (U. of Wisconsin, Madison), D. Meldrum, G. Jabbour (Arizona State U.), M. Salmeron (UC Berkeley), P. Weiss, (UCLA), B. Tang, (HK Science & Technology U.), H. Chen (Zhejiang U.)

CURRICULUM VITAE Wen-Feng Hsieh (謝文峰) Department of Electro-Optical Engineering National Cheng Kung University 1, University Rd., Tainan 701, Taiwan Telephone: 886-6-2757575 ext 65281, Fax: 886-62095040, Email: [email protected] Website: http://www.ieo.nctu.edu.tw/wfhsieh 1. Personal Information Birth: Taiwan, 1955

2. Educations 1977 1979 1986 1988

National Cheng Keng University B.S. in Physics National Tsing Hwa University M.S. in Physics Yale University MPh in Applied Physics Yale University Ph. D. in Applied Physics (Advisor: Prof. Richard K. Chang) 3. Professional Experiences Telecommunication Laboratories, Ministry of Communication, Taiwan, R.O.C. 1981-1984 Assistant research fellow National Chiao Tung University 1988 -1992 Associate Professor of Institute of Electro-Optical Engineering 1992 Professor of Institute of Electro-Optical Engineering 2001 - 2003 Director, Institute of Electro-Optical Engineering 2003 -present Chair, faculty search committee of Institute of Electro-Optical Engineering National Cheng Kung University 2009/2-present Director, Institute of Electro-Optical Science and Engineering 2009/2-present Chairman, Department of Electro-Optical Engineering 4. Fields of Specialty - Nonlinear dynamics of solid state lasers - Laser spectroscopy and carrier dynamics of ZnO nanostructures such as quantum dots and quantum wells - Theoretical modeling on photonic crystal waveguide couplers - Theoretical study on quantum optics in structured photonic reservoirs. 5. Major awards and honors Member, Optical Society of America Senior member, Physics Society of Republic of China (PSROC) 1994-present Board of Executive, PSROC 1995-present Academic committee, PSROC 1993 Associate Editor of bimonthly magazine of PSROC 1994-1995 Executive Editor of bimonthly magazine of PSROC 1995-1996 Committee of project review board, Division of Natural Science, National Science Council (NSC) 1997-1999 Program Coordinator of Condensed Matter Physics, Division of Natural Science, NSC 1997-1998 Committee of review board for precision equipments, NSC

1997-1999 Committee of National Projects of Central Government, R.O.C. 2007-present Committee of review board for capital equipments, NSC 2009-present Committee of project review board, Division of Electro-Optics, National Science Council (NSC) 1998 Program committee of International photonic conference (IPC’98) 2000 Program committee of International photonic conference (IPC’2000) 2008/8-present Editorial Board, International Journal of Optics, Hindawi Publishing Corporation Awards 1989-1990 Research Award of NSC 1991-1993 Research Excellence Award of NSC (canceled after 1993) 1994-2000 Research Award of NSC (canceled after 2000) 2007-2009 Research Excellence Award of National Chiao Tung University 6. List of Recent Selected Publications (* corresponding author)

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13.

Hsu-Cheng Hsu and Wen-Feng Hsieh*, “Excitonic polaron and phonon assisted photoluminescence of ZnO nanowires,” Solid State Communications 131, 371-375 (2004). Hsu-Cheng Hsu, Yung-Kuan Tseng, Hsin-Min Cheng, Jia-How Kuo, and Wen-Feng Hsieh*, “Selective growth of ZnO nanorods on pre-coated ZnO buffer layer,” Journal of Crystal Growth 261, 520-525 (2004). Ja-Hon Lin, Yin-Jen Chen, Hung-Yu Lin, and Wen-Feng Hsieh*, “Two-photon resonance assisted huge nonlinear refraction and absorption in ZnO thin films,” J. Appl. Phys. 97, 033526 (2005). Hsu-Cheng Hsu, Ching-Sheng Cheng, Chia-Chieh Chang, Song Yang, Chen-Shiung Chang, and Wen-Feng Hsieh*, “Orientation-enhanced growth and optical properties of ZnO nanowires grown on porous silicon substrates,” Nanotechnology 16, 297-301 (2005). Hsu-Cheng Hsu, Chun-Yi Wu, and Wen-Feng Hsieh*, “Stimulated emission and lasing of random growth-oriented ZnO nanowires,” Journal of Applied Physics 97, 064315 (2005). Hsin-Min Cheng, Hsu-Cheng Hsu, Yung-Kuan Tseng, Li-Jiaun Lin, and Wen-Feng Hsieh* , “Raman scattering and efficient UV photoluminescence from well-aligned ZnO nanowires epitaxially grown on GaN buffer layer,” Journal of Physical Chemistry B 109, 8749-8754 (2005). Lin KF, Cheng HM, Hsu HC, Lin LJ, and Hsieh WF*, “Band gap variation of size-controlled ZnO quantum dots synthesized by sol-gel method,” CHEMICAL PHYSICS LETTERS 409 (4-6): 208211 JUN 30 (2005). Cheng HM, Hsu HC, Yang S, Wu CY, Lee YC, Lin LJ, and Hsieh WF*, “The substrate effect on the in-plane orientation of vertically well-aligned ZnO nanorods grown on ZnO buffer layers,” NANOTECHNOLOGY 16 (12): 2882-2886 DEC 2005 Cheng HM, Lin KF, Hsu HC, Lin CJ, Lin LJ, and Hsieh WF*, “Enhanced resonant Raman scattering and electron-phonon coupling from self-assembled secondary ZnO nanoparticles,” JOURNAL OF PHYSICAL CHEMISTRY B 109 (39): 18385-18390 OCT 6 2005 Liu WR, Hsieh WF, Hsu CH, Liang KS, and Chien FSS, “Influence of the threading dislocations on the electrical properties in epitaxial ZnO thin films,” JOURNAL OF CRYSTAL GROWTH 297 (2): 294-299 DEC 29 2006 Hsu HC, Wu CY, Cheng HM, and Hsieh WF*, “Band gap engineering and stimulated emission of ZnMgO nanowires,” APPLIED PHYSICS LETTERS 89 (1): Art. No. 013101 JUL 3 2006 Cheng HM, Lin KF, Hsu HC, and Hsieh WF*, “Size dependence of photoluminescence and resonant Raman scattering from ZnO quantum dots,” APPLIED PHYSICS LETTERS 88 (26): Art. No. 261909 JUN 26 2006 Lin KF, Cheng HM, Hsu HC, and Hsieh WF*, “Band gap engineering and spatial confinement of optical phonon in ZnO quantum dots,” APPLIED PHYSICS LETTERS 88 (26): Art. No. 263117 JUN 26 2006

14. Hsu HC, Cheng HM, Wu CY, Huang HS, Lee YC, and Hsieh WF*, “Luminescence of selective area growth of epitaxial ZnO nanowires and random-growth-oriented nanobelts,” NANOTECHNOLOGY 17 (5): 1404-1407 MAR 14 2006 15. Kuo SY, Chen WC, Lai FI, Cheng CP, Kuo HC, Wang SC, and Hsieh WF, “Effects of doping concentration and annealing temperature on properties of highly-oriented al-doped ZnO films,” JOURNAL OF CRYSTAL GROWTH 287 (1): 78-84 JAN 18 2006. 16. Wu CY, Hsu HC, Cheng HM, Yang S, Hsieh WF*, “Structural and optical properties of ZnO nanosaws,” JOURNAL OF CRYSTAL GROWTH 287 (1): 189-193 JAN 18 2006 17. Tung-Ching Huang, Mei-Tan Wang, Hwo-Shuenn Sheu, and Wen-Feng Hsieh*, “Size-dependent lattice dynamics of barium titanate nanoparticles”, JOURNAL OF PHYSICS-CONDENSED MATTER 19 (47), 476212 (2007). 18. Wei-Tse Hsu, Kuo-Feng Lin, and Wen-Feng Hsieh*, “Reducing exciton-longitudinal-optical phonon interaction with shrinking ZnO quantum dots,” APPLIED PHYSICS LETTERS 91 (18), 181913 (2007). 19. Ching-Ju Pan, Kuo-Feng Lin, and Wen-Feng Hsieh*, “Acoustic and optical phonon assisted formation of biexcitons,” APPLIED PHYSICS LETTERS 91 (11), 111907 (2007). 20. Wei-Ren Liu, Wen-Feng Hsieh, Chia-Hong Hsu, Keng-San Liang, Forest S.-S. Chien, “Threading dislocations in domain-matching epitaxial films of ZnO,” JOURNAL OF APPLIED CRYSTALLOGRAPHY 40, 924-930 (2007). 21. Ching-Ju Pan, Hsu-Cheng Hsu, Hsin-Ming Cheng, Chun-Yi Wu, and Wen-Feng Hsieh*, “Structural and optical properties of ZnMgO nanostructures formed by Mg in-diffused ZnO nanowires,” JOURNAL OF SOLID STATE CHEMISTRY 180 (4), 1188-1192 (2007). 22. Ching-Ju Pan, Kuo-Feng Lin, Wei-Tse Hsu, and Wen-Feng Hsieh*, “Raman study of alloy potential fluctuations in MgxZn1-xO nanopowders,” JOURNAL OF PHYSICS-CONDENSED MATTER 19 (18), 186201 (2007). 23. Forest S.-S. Chien, J. B. Tu, Wen-Feng Hsieh*, and Szu-Cheng Cheng, “Tight-binding theory for coupled photonic crystal waveguides,” PHYSICAL REVIEW B 75 (12), 125113 (2007). 24. Ching-Ju Pan, Kuo-Feng Lin, Wei-Tse Hsu, and Wen-Feng Hsieh*, “Reducing exciton-longitudinal optical phonon coupling with increasing Mg incorporation in MgZnO powders,” J. OF APPLIED PHYSICS 102(12), 123504 (2007). 25. Ching-Ju Pan, Kuo-Feng Lin, Wei-Tse Hsu, and Wen-Feng Hsieh*, “Reducing exciton-longitudinal optical phonon coupling with increasing Mg incorporation in MgZnO powders,” JOURNAL OF APPLIED PHYSICS, 102(12) 123504 (2007). 26. W-R Liu, Y-H Li, W. F. Hsieh*, C-H Hsu, W. C. Lee, M. Hong, J. Kwo, “Correlation between crystal structure and photoluminescence for epitaxial ZnO on Si(111) using a gamma-Al2O3 buffer layer,” JOURNAL OF PHYSICS D-APPLIED PHYSICS, 41(6) 065105 (2008). 27. K. F. Lin and W. F. Hsieh*, “Electronic structures and surface states of ZnO finite well structures,” JOURNAL OF PHYSICS D-APPLIED PHYSICS 41(21), 215307 (2008). 28. Hsin-Ming Cheng, Wei-Hao Chiu, Chia-Hua Lee, Song-Yeu Tsai and Wen-Feng Hsieh*, “Formation of Branched ZnO Nanowires from Solvothermal Method and Dye-Sensitized Solar Cells Applications,” JOURNAL OF PHYSICAL CHEMISTRY C 112(42), 16359-16364 (2008). 29. Yun-Pei Chan, Ja-Hon Lin, Chih-Chang Hsu and Wen-Feng Hsieh*, “Near-resonant high order nonlinear absorption of ZnO thin films,” OPTICS EXPRESS 16(24), 19900-19908 (2008). 30. C. H. Huang, W. F. Hsieh* and S. C. Cheng, “Tuning the decoupling point of a photonic-crystal directional coupler,” JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS 26(2), 203-209 (2009). 31. Chih-Hsien Huang, Ying-Hsiuan Lai, Szu-Cheng Cheng, Wen-Feng Hsieh*, “Modulation instability in nonlinear coupled resonator optical waveguides and photonic crystal waveguides,” OPTICS EXPRESS 17(3), 1299-1307 (2009). 32. Szu-Cheng Cheng, Jing-Nuo Wu, Tzong-Jer Yang, and Wen-Feng Hsieh*, “Effect of atomic position on the spontaneous emission of a three-level atom in a coherent photonic-band-gap reservoir,” PHYSICAL REVIEW A 79(1), 013801 (2009).

33. C. H. Huang, W. F. Hsieh* and S. C. Cheng, “Physical properties of asymmetric photonic crystal waveguides,” JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS 11(1), 015103 (2009). 34. W. -R. Liu, Y. -H. Li, Hsieh, W. F.*, C. -H. Hsu, W. C. Lee, Y. J. Lee, M. Hong, and J. Kwo, “Domain Matching Epitaxial Growth of High-Quality ZnO Film Using a Y2O3 Buffer Layer on Si (111),” CRYSTAL GROWTH & DESIGN 9(1), 239-242 (2009). 35. Szu-Cheng Cheng, Jing-Nuo Wu, Ming-Rung Tsai and Wen-Feng Hsieh*, “Spontaneous emission near the band edge of a three-dimensional photonic crystal: a fractional calculus approach,” JOURNAL OF PHYSICS-CONDENSED MATTER 21(1), 015503 (2009). 36. K. F. Lin, C. J. Pan, W. F. Hsieh*, “Calculations of electronic structure and density of states in the wurtzite structure of Zn1-xMgxO alloys using sp3 semi-empirical tight-binding model,” APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 94(1), 167-171 (2009). 37. Wei-Hao Chiu, Chia-Hua Lee, Hsin-Ming Cheng, Hsiu-Fen Lin, Shih-Chieh Liao, Jenn-Ming Wu and Wen-Feng Hsieh*, “Efficient electron transport in tetrapod-like ZnO metal-free dye-sensitized solar cells,” Energy Environ. Sci. 2, 694 (2009).

CURRICULUM VITAE MICHAEL J. HOCHBERG September 22, 2009 EMPLOYMENT: Sept. 2008-present

Assistant Professor, Department of Electrical Engineering University of Washington, Seattle, WA

Sept. 2007-Sept. 2008

Acting Assistant Professor Temporary, Department of Electrical Engineering, University of Washington

Sept. 2007-Jan. 2008

Research Staff Member, Nanofabrication Group, California Institute of Technology, Pasadena, CA

July 2007-Sept. 2007

Scientific Research Associate, Nanofabrication Group, California Institute of Technology

May 2006-July 2007

Postdoctoral Scholar, Nanofabrication Group, California Institute of Technology

Nov. 2001-Sept. 2003

Staff Scientist, Luxtera, Inc.

June 1999-Nov. 2001

President, Simulant, Inc.

EDUCATION: Sept. 2005-June 2006

Ph.D., California Institute of Technology, Applied Physics

Sept. 2003-June 2005

M.A., California Institute of Technology, Applied Physics

Sept. 1998-June 2002

B.S., California Institute of Technology, Physics

AWARDS, FELLOWSHIPS, AND RECOGNITIONS: July 2009

2008 Presidential Early Career Award for Scientists and Engineers (PECASE), sponsored by the Department of Defense (AFSOR)

July 2008

Washington State Star Researcher

Nov 2007

U.S. Air Force Young Investigator Program Award

June 2006

California Institute of Technology Demetriades-Tsafka Prize for the best thesis by a graduating Ph.D. student in the field of nanotechnology

March 2002

National Science Foundation Graduate Research Fellowship

2001-2002

California Institute of Technology Merit Scholarship

May 2000

Caltech 10K Business Plan Competition. Startup funds for Simulant, Inc. provided by the Center for Neuromorphic Systems Engineering (CNSE) 7 Accepted; 33 Pending

PATENTS: RESEARCH GRANTS: 2009-2014

M. Hochberg, PI. Presidential Early Career Award in Science and Education (PECASE). $200,000 a year for five years

2009-2012

Joseph Perry, PI; M. Hochberg, Co-PI. Materials and devices for Zeno-based opto-electronics. Duration 3 years; total grant for UW Nanophotonics Laboratory: $750,000

2009-2012

Daniel Ratner, PI, M. Hochberg, Co-PI. Enhanced molecular detection and biosensing of carbohydrate-medicated interactions through integrated silicon nanophotonics. Biophotonics, Adv Imaging, & Sensing for Human Health, National Science Foundation. $630,000 for three years total funding; Nanophotonics Group support approximately half of total

Oct. 2008-Sept. 2010 M. Hochberg, PI. Single photon adiabatic wavelength converter on silicon chip. National Science Foundation (Rochester Institute of Technology subcontract). $25,000 over two years 2008-2011

M. Hochberg, PI. Nanophotonic devices in silicon for nonlinear optics. NSF Science and Technology Center (STC) Seed Grant. $100,000 per year for 3 years

2008-2011

M. Hochberg, PI. Nanophotonic devices in silicon for nonlinear optics. U.S. Air Force Office of Scientific Research (AFOSR). Supplemental grant will fund research performed by the UW Applied Physics Lab. $80,000 over three years

2008

M. Hochberg, PI. Establishment of a shared optoelectronic device test facility. Murdoch Trust. $470,000 (plus $235,000 in UW matching funds)

July 2008

M. Hochberg, PI. Washington State Innovation Research Teams Program, award of $1,310,000 in support of the acquisition of an electron beam lithography system for a shared facility at the University of Washington

July 2008

M. Hochberg, PI. Washington Research Foundation, award of $1,300,000 in support of the acquisition of an electron beam lithography system for a shared facility at the University of Washington

Nov 2007

M. Hochberg, PI. Nanophotonic devices in silicon for nonlinear optics. U.S. Air Force Office of Sponsored Research (AFOSR) Young Investigators Program Award, $300,000 over 3 years

GIFTS: July 8, 2009

Washington Research Foundation. Donation of $250,000 in support of research at the UW Nanophotonics Laboratory

April 4, 2009

Intel Corp. Donation of electronics equipment (i.e., tencor profilometer), $35,000

Aug. 29, 2008 Tektronix. Donation of electronics equipment at less than list price (i.e., $133,300, provided at $13,300) May 2008

Intel Corp. Electromagnetic Simulation Cluster for Nanophotonics. Donation of computers, $30,000

Feb. 4, 2008

Tektronix. Donation of electronics equipment at less than list price (i.e., $129,900; provided at $26,059)

PERSONAL AND CONTACT INFORMATION: Mobile no.:

626-429-4051

E-mail address:

[email protected]

Mail address:

Paul Allen Center–Room AE100R, Campus Box 352500, University of Washington, Seattle, WA 98195-2500

Shoou-Jinn Chang Institute of Microelectronics & Department of Electrical Engineering National Cheng Kung University, Tainan, 70101, TAIWAN Tel: +886-6-2757575 ext 62391 (O) +886-6-2379110 (H) +886-929-361-018 (M) Fax: +886-6-2761854 e-mail: [email protected] Date of Birth: January 17th, 1961 Height: 167cm Weight: 82Kg Nationality: Taiwan, ROC Educational Background Ph.D. degree, Aug. 1989 Electrical Engineering Department, University of California, Los Angeles Major: Solid State Electronics, Minors: Quantum Electronics, Circuit Design Dissertation title: “Studies of molecular beam epitaxially grown GexSi1-x/Si strained layer superlattice” M.S. degree, Aug. 1985 Department of Electrical Engineering, State University of New York at Stony Brook B.S. degree, June 1983 Department of Electrical Engineering, National Cheng Kung University Working Experience: Professor (08/98-present) Department of Electrical Engineering, National Cheng Kung University Director (08/08-present) Institute of Microelectronics, NCKU Director (08/97-present) Semiconductor Research Center, NCKU Honorary professor (02/02-present) Changchun University of Science and Technology, China Visiting Scholar (07/04-09/04) Department of Electrical, Electronic and Bioengineering, Waseda University, Japan Visiting Scholar (08/02-09/02) Institute of Physics, Stuttgart University, Germany Visiting Scholar (08/01-09/01) Institute of Microstructural Science, National Research Council, Canada Visiting Scholar (07/99-02/00) Research Center for Advanced Science and Technology, University of Tokyo, Japan Royal Society Visiting Scholar (01/99-03/99) University of Wales, Swansea, UK Associate Professor (08/92-07/98) Department of Electrical Engineering, National Cheng Kung University Research Scientist (08/89-08/92) Physical Science Research Laboratory NTT Basic Research Laboratories, Musashino, Tokyo, Japan Research interests: Semiconductor Physics, Optoelectronic devices, Nanotechnology Publications: see attached publication list Awards: Young Engineer’s Award, Chinese Engineering Society, 1999 Marubun Research Foundation Exchange Award, 2000 Outstanding Research Award, NSC, TAIWAN, 2004 Outstanding Professor Award, Chinese Electrical Engineering Society, 2007 1

BIOGRAPHICAL SKETCH NAME

POSITION TITLE

Lin, Lih Y.

Professor of Electrical Engineering

EDUCATION/TRAINING INSTITUTION AND LOCATION

National Taiwan University National Taiwan University University of California, Los Angeles University of California, Los Angeles

DEGREE (if applicable)

YEAR(s)

B.S. M.S. M.S. Ph.D.

1990 1992 1993 1996

FIELD OF STUDY

Physics Physics Electrical Engineering Electrical Engineering

A. Positions and Honors. Positions and Employment 1995 Member of Technical Staff (summer internship), High Speed Electronics Research Department, AT&T Bell Laboratories, Murray Hill, NJ 1996-2000 Senior Technical Staff Member, High-speed Networks Research Department, AT&T Labs-Research, NJ 2000-2002 Director of Optical Technologies, Tellium, Inc., NJ 2003-2009 Associate Professor, Electrical Engineering Department, University of Washington, Seattle, WA 2009Professor, Electrical Engineering Department, University of Washington, Seattle, WA Other Experience and Professional Memberships 1994Member of IEEE 1996Member of Optical Society of America (OSA) 1998-2005 Technical program committee, International Conference on Optical MEMS and Its Applications 1999-2001 Sub-committee chair, OSA Annual Meeting 1999-2006 Steering committee, International Conference on Optical MEMS and Its Applications 2001 Technical program committee, IEEE LEOS Annual Meeting 2001 Conference co-chair, International Conference on Optical MEMS and Its Applications 2001-2002 Technical program committee, OSA Photonics in Switching Topical Meeting 2001-2002 Sub-committee co-chair, Asia-Pacific Optical and Wireless Communications Conference 2003 Sub-committtee co-chair, Conference on Lasers and Electro-Optics, Pacific Rim 2004Member of AAAS 2004-2006 Technical program committee, SPIE’s International Symposium on Nanosensing 2005-2006 Technical program committee, SPIE’s International Symposium on MOEMS-MEMS 2005 Technical program committee, Conference on Lasers and Electro-Optics, Pacific Rim 2006 Technical program committee chair, International Conference on Optical MEMS and Its Applications 2007-2008 Technical program committee, International Conference on Optical MEMS and Nanophotonics 2007-2010 Steering committee, International Conference on Optical MEMS and Nanophotonics 2009 General chair, Internation Conference on Optical MEMS and Nanophotonics 2009-2010 Technical program committee, Optical Fiber Communications Conference 2010 Technical program committee, International Conference on Optical MEMS and Nanophotonics Honors 2010 Elected to IEEE Fellow 2005 Invitee to the National Academy of Engineering 2005 Frontiers of Engineering Symposium. 2003 MIT Technology Review 100 Award 2001 IEEE Eta Kappa Nu Outstanding Young Electrical Engineer, Finalist 1997 Outstanding Doctor of Philosophy (highest honor) of UCLA School of Engineering and Applied Science 1996 Meritorious Paper Award from the Government Microcircuit Applications Conference (GOMAC) 1995-1996 GTE Fellowship PHS 398/2590 (Rev. 11/07)

13 Page ___

Biographical Sketch Format Page

1995

The Bor-Uei Chen Memorial Scholarship from the Photonics Society of Chinese Americans

B. Selected peer-reviewed publications (in chronological order). (Publications selected from 53 refereed journal papers and more than 120 conference publications) 1. L. Y. Lin, E. L. Goldstein, and R. W. Tkach, “Free-space micromachined optical switches with sub-millisecond switching time for large-scale optical crossconnect,” IEEE Photonics Technol. Lett., Vol. 10, no. 4, p. 525-527, 1998. 2. L. Y. Lin, E. L. Goldstein, and R. W. Tkach, "Free-space micromachined optical switches for optical networking," IEEE J. Selected Topics in Quantum Electronics: Microoptoelectromechanical systems (MOEMS), Vol. 5, p. 4-9, 1999. 3. Lih Y. Lin and Evan L. Goldstein, “Opportunities and challenges for MEMS in lightwave communications,” IEEE J. of Sel. Top. in Quan. Elec. on Review of Telecom Network Application of MEMS, 8(10): 163-172, 2002 (Invited paper). 4. “Micro-Electro-Mechanical Systems (MEMS) for Optical-Fiber Communication,” by Lih Y. Lin, in WDM Technologies ― Passive Optical Components, edited by A. K. Dutta, N. K. Dutta, and M. Fujiwara, Academic Press, 2003. 5. Wang, C.-J. and Lin, L.Y., “Sub-diffraction limit nano-photonic waveguides by quantum dot array structure ― Modeling and simulation,” SPIE’s International Symposium on Nanosensing, Philadelphia, PA, 2004 (Invited paper). 6. Chia-Jean Wang, Lih Y. Lin, and Babak A. Parviz, “Modeling and simulation for a nano-photonic quantum dot waveguide fabricated by DNA-directed self-assembly,” IEEE J. Sel. Topics in Quan. Elec., 11(2): 500-509, 2005. 7. Hegg, M. C., Horning, M. P., and Lin, L. Y., “Nano-scale quantum dot photodetector by self-assembly,” SPIE Optical East on Nanosensors, Boston, MA, Oct. 23-26, 2005 (Invited paper). 8. Chia-Jean Wang, Ludan Huang, Babak A. Parviz, and Lih Y. Lin, “Sub-diffraction photon guidance by quantum dot cascades,” Nano Letters, 6(11): 2549-2553, Nov. 2006. Also selected by Nature Photonics as research highlight: “Nanophotonics: Guiding the way – Quantum dots help to guide light at the subdiffraction limit,” Nature Photonics, 1(1): 8, January 2007. 9. Xiaoyu Miao and Lih Y. Lin, “Large dielectrophoresis force and torque induced by localized surface plasmon resonance of a cap-shaped Au nanoparticle array,” Optics Letters, 32(3): 295-297, Feb. 2007. 10. Ludan Huang, Chia-Jean Wang, and Lih Y. Lin, “A comparison of crosstalk effects between colloidal quantum dot waveguides and conventional waveguides,” Optics Letters, 32(3): 235-237, Feb. 2007. 11. Chia-Jean Wang and Lih Y. Lin, “Nanoscale waveguiding methods,” Nanoscale Research Letters, May 1, 2007, (Invited paper). 12. Lih Y. Lin, Chia-Jean Wang, Michael Hegg, and Ludan Huang, “Nanocrystal quantum dot waveguides and photodetectors,” International Nano-Optoelectronic Workshop, Beijing and Lanzhou, China, July 29-Aug. 11, 2007 (Invited paper). 13. Lih Y. Lin, Xiaoyu Miao, and Chih-Cheng Cheng “Enhanced optical manipulation through plasmonics,” IEEE LEOS Annual Meeting, Special Symposium on Optical MEMS & NEMS, Orlando, FL, Oct. 21-25, 2007 (Invited paper). 14. Xiaoyu Miao and Lih Y. Lin, “Trapping and manipulation of biological particles through a plasmonic platform,” IEEE Journal of Selected Topics in Quantum Electronics: Special Issue on Biophotonics, 13(6): 1655-1662, 2007. 15. Michael C. Hegg and Lih Y. Lin, “Near-field photodetection with high spatial resolution by nanocrystal quantum dots,” Optics Express, 15(25): 17163-17170, Dec. 10, 2007. Also selected by Nature Photonics as research highlight: “Colloidal quantum dots – Filling the gap,” Nature Photonics, 2(2): 65, February 2008. 16. Xiaoyu Miao, Benjamin K. Wilson and Lih Y. Lin, “Localized surface plasmon assisted microfluidic mixing,” Applied Physics Letters, 92:124108, March 2008. 17. C. J. Wang, B. A. Parviz and L. Y. Lin, “Two dimensional array self-assembled quantum dot sub-diffraction waveguides with low loss and low crosstalk,” Nanotechnology, 19(23): 295201, June 10, 2008. 18. Benjamin K. Wilson and Lih Y. Lin, “Variable wave plate via tunable form-birefringent structures,” Journal of Microelectromechanical Systems, 17(4): 1039-1046, 2008. 19. Xiaoyu Miao, Benjamin K. Wilson, Suzie H. Pun and Lih Y. Lin, “Optical manipulation of micron/submicron sized particles and biomolecules through plasmonics,” Optics Express, 16(18): 13517-13525, Aug. 18, 2008. 20. Lih Y. Lin, Xiaoyu Miao and Benjamin Wilson, “Plasmonic tweezers for opto-fluidics,” IEEE LEOS Summer Topical Meeting, Acapulco, Mexico, July 21-23, 2008 (Invited paper). 21. Lih Y. Lin, Xiaoyu Miao and Benjamin Wilson, “Trapping and manipulation of biological particles using plasmonic tweezers,” EMBS-LEOS Joint Symposium: Advanced Biophotonic Diagnostics and Therapeutics, part of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Vancouver, Canada, August 20-24, 2008 (Invited paper). 22. Benjamin K. Wilson, Mike Hegg, Xiaoyu Miao, Guozhong Cao and Lih Y. Lin, “Scalable nano-particle assembly by efficient light-induced concentration and fusion,” Optics Express, 16(22): 17276-17281, Oct. 2008. 23. Lih Y. Lin, Chia-Jean Wang, Michael C. Hegg, and Ludan Huang, “Quantum dot nanophotonics – From waveguiding to integration,” Journal of Nanophotonics, 3(1):031603, 2009 (Invited review paper). 24. Xiaoyu Miao, Benjamin K. Wilson, Guozhong Cao, Suzie H. Pun, and Lih Y. Lin, “Trapping and rotation of nanowires assisted by surface plasmons,” IEEE Journal of Selected Topics in Quantum Electronics: Special Issue on Nanophotonics and Optical MEMS, 15(5): 1515-1520, Sep./Oct. 2009.

CURRICULUM VITAE Wen-Shuo Kuo (郭文碩) Department of Engineering Science, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6-2385822; Fax: +886-6-2766549; Mobile Phone : 0921510385; E-mail: [email protected] [email protected]

1. Personal Information Birth: Tainan, Taiwan, 1978.

2. Educations 2009.7 2003.2 2000.6

Chemistry, National Cheng Kung University, Ph.D. Biochemistry, National Cheng Kung University, M.S. Chemistry, National Cheng Kung University, B.S.

3. Professional Experiences 2009.9~

Department of Engineering Science, National Cheng Kung University, Postdoctoral Fellow

4. Fields of Specialty - Bio-Medical Nanomaterials - Molecular Biological Imaging - Molecular Biology 5. Major awards and honors - “The Phi Tau Phi Scholastic Honor Society of The Republic of China” from National Cheng Kung University in 2009.

6. List of Recent Selected Publications (* corresponding author) - Wen-Shuo Kuo, Ching-Ming Wu, Zih-Syuan Yang, Szu-Yu Chen, Cheng-Ying Chen, Chih-Chia Huang, Wei-Ming Li, Chi-Kuang Sun and Chen-Sheng Yeh.* Biocompatible bacteria@Au composites for application in the photothermal destruction of cancer cells. Chem. Commun. 2008, 37, 4430-4432. - Chih-Chia Huang, Yi-Wei Lo, Wen-Shuo Kuo, Jih-Ru Hwu, Wu-Chou Su, Dar-Bin Shieh and Chen-Sheng Yeh.* Facile preparation of self-assembled hydrogel-like GdPO4·H2O nanorods. Langmuir. 2008, 24, 8309-8313. - Chih-Chia Huang, Wileen Huang, Chia-Hao Su, Chieh-Ning Feng, Wen-Shuo Kuo and Chen-Sheng Yeh.* A general approach to silicate nanoshells: gadolinium silicate and gadolinium silicate:europium nanoshells for dual-modality optical and MR imaging. Chem. Commun. 2009, 23, 3360-3362. - Wen-Shuo Kuo, Chich-Neng Chang, Yi-Ting Chang and Chen-Sheng Yeh.* Antimicrobial gold nanorods with dual-modality photodynamic inactivation and hyperthermia. Chem. Commun. 2009, 32, 4853-4855. - Wen-Shuo Kuo, Shiaw-Min Hwang, Hei-Tin Sei, Yu-Cian Ku, Lee-Feng Hsu, Fong-Yu Cheng, Patrick Ching-Ho Hsieh and Chen-Sheng Yeh.* Stabilizer-free poly(lactide-co-glycolide) nanoparticles conjugated with quantum Dots as a potential carrier applied in human mesenchymal stem cells J. Chin. Chem. Soc. 2009, 56, 940-948. - Wen-Shuo Kuo, Yu-Cian Ku, Hei-Tin Sei, Fong-Yu Cheng and Chen-Sheng Yeh.* Paclitaxel-loaded stabilizer-free poly(D,L-lactide-co-glycolide) nanoparticles conjugated with quantum dots for reversion of anti-cancer drug resistance and cancer cellular imaging. J. Chin. Chem. Soc. 2009, 56, 923-934. - Wen-Shuo Kuo,* Chich-Neng Chang, Yi-Ting Chang, Meng-Heng- Yang, Yi-Hsin Chien, shean-Jen Chen and Chen-Sheng Yeh.* Near-infrared Au nanorods in photodynamic therapy, hyperthermia, and near-infrared optical imaging. Angew. Chem. Int. Ed. 2010. (accepted)

CURRICULUM VITAE Shean-Jen Chen (陳顯禎) Department of Engineering Science, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6-2757575 ext. 63351; Fax: +886-6-2766549; E-mail: [email protected]

1. Personal Information Birth: Tainan, Taiwan, 1965.

2. Educations: 1997.1 1992.2 1987.6

Mechanical Engineering, UCLA, Ph.D. Mechanical Engineering, Columbia University, M.S. Agricultural Machinery Engineering, National Taiwan University, B.S.

3. Professional Experiences: 2010.1~ 2007.8~ 2008.6~2008.9 2004.8~2007.7 2003.8~2004.7 2000.8~2003.7 1998.1~2000.7

Center for Micro/Nano Science and Technology, National Cheng Kung University, Deputy Director Department of Engineering Science, and Institute of Electro-Optical Science and Engineering, National Cheng Kung University, Professor Department of Biological Engineering, Massachusetts Institute of Technology, Visiting Professor Department of Engineering Science, and Institute of Electro-Optical Science and Engineering, National Cheng Kung University, Associate Professor Department of Engineering Science, National Cheng Kung University, Assistant Professor Institute of Optical Science & Department of Mechanical Engineering, National Central University, Assistant Professor Synchrotron Radiation Research Center, Assistant Research Scientist

4. Fields of Specialty: - Nanoplasmonic Biosensing & Molecular Imaging - Adaptive Optics in Biological Microscopy

5. Major awards and honors - “Wu Ta You Memorial Award” from National Science Council of Taiwan for research excellence in 2005.

6. List of Recent Selected Publications - W. P. Hu, S.-J. Chen*, K.-T. Huang, J. H. Hsu, W. Y. Chen, G. L. Chang, and K.-A. Lai, “A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film,” Biosensors & Bioelectronics 19 (2004) 1465. - S.-J. Chen*, F. C. Chien, G. Y. Lin, and K. C. Lee, “Enhanced the resolution of surface plasmon resonance biosensors by controlling size and distribution of nanoparticles,” Optics Letters 29 (2004) 1390. - F.-C. Chien and S.-J. Chen*, “A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes,” Biosensors & Bioelectronics 20 (2004) 633. - S.-J. Chen*, Y.-D. Su, F.-M. Hsiu, C.-Y. Tsou, and Y.-K. Chen, “Surface plasmon resonance phase-shift interferometry: Real-time DNA microarray hybridization analysis,” J. Biomedical Optics 10 (2005) 034005. - Y.-D. Su, S.-J. Chen*, and T.-L. Yeh, “Common-path phase-shift interferometry surface plasmon resonance imaging system,” Optics Letters 30 (2005) 1488. - F.-C. Chien and S.-J. Chen*, “Direct determination of the refractive index and thickness of bio-layer based on coupled waveguide-surface plasmon resonance mode,” Optics Letters 31 (2006) 187. - W. P. Hu, H.-Y. Hsu, A. Chiou, K. Y. Tseng, G. L. Chang, and S.-J. Chen*, “Immunodetection of pentamer and modified C-reactive protein using surface plasmon resonance biosensing,” Biosensors & Bioelectronics 21 (2006) 1631. - R.-Y. He, G.-L. Chang, H.-L. Wu, C.-H. Lin, K.-C. Chiu, Y.-D. Su, and S.-J. Chen*, “Enhanced live cell membrane imaging using surface plasmon-enhanced total internal reflection fluorescence microscopy,” Optics Express 14 (2006) 9307. - F.-C. Chien, C.-Y. Lin, J.-N. Yih, K.-L. Lee, C.-W. Chang, P.-K. Wei, C.-C. Sun, and S.-J. Chen*, “Coupled waveguide-surface plasmon resonance biosensors constructed with sub-wavelength gratings,” Biosensors & Bioelectronics 22 (2007) 2737.

- K.-H. Lee, Y.-D. Su, S.-J. Chen, F.-G. Tseng and G.-B. Lee, “Microfluidic systems integrated with two-dimensional surface plasmon resonance phase imaging systems for microarray immunoassay,” Biosensors & Bioelectronics 23 (2007) 466. - V. Hovhannisyan, W. Lo, C. Hu, S.-J. Chen, C. Y. Dong, “Dynamics of femtosecond laser photo-modification of collagen fibers,” Optics Express 16 (2008) 7958. - Y.-L. Chiang, C.-H. Lin, M.-Y. Yen, Y.-D. Su, S.-J. Chen, H.-F. Chen, “Innovative antimicrobial susceptibility testing method using surface plasmon resonance,” Biosensors & Bioelectronics 24 (2009) 1905. - R.-Y. He, Y.-D. Su, K.-C. Cho, C.-Y. Lin, N.-S. Chang, C.-H. Chang, and S.-J. Chen*, “Surface plasmon-enhanced two-photon fluorescence microscopy for live cell membrane imaging,” Optics Express 17 (2009) 5987. - Q. Hong, C.-I Sze, S.-R. Lin, M.-H. Lee, R.-Y. He, L. Schultz, L.-J. Hsu, S.-J. Chen, R. J. Boackle, and N.-S. Chang, “Complement C1q activates tumor suppressor WWOX to kill prostate cancer cells: downregulation of C1q in hyperplasia and cancerous prostate,” PLoS ONE 4 (2009) e5755. - P.-J. Su, W.-L. Chen, J.-B. Hong, T.-H. Li, R.-J. Wu, C.-K. Chou, S.-J. Chen, C. Hu, S.-J. Lin, and C.-Y. Dong, “Discrimination of collagen in normal and pathological skin dermis through second-order susceptibility microscopy,” Optics Express 17 (2009) 11161. - C.-H. Lin, L. Jiang, H. Xiao, Y.-H. Chai, S.-J. Chen, and H.-L. Tsai, “Fabry-Perot interferometer embedded in a glass chip fabricated by femtosecond laser,” Optics Letters 34 (2009) 2408. - W. Lo, Y.-L. Chang, J.-S. Liu, C.-M. Hseuh, V. Hovhannisyan, S.-J. Chen, H.-Y. Tan, and C.-Y. Dong, “Multimodal, multiphoton microscopy and image correlation analysis for characterizing corneal thermal damage,” J. Biomedical Optics 14, (2009) 054003. - C.-H. Lin, L. Jiang, Y.-H. Chai, H. Xiao, S.-J. Chen, and H.-L. Tsai, “One-step fabrication of nanostructures by femtosecond laser for surface-enhanced Raman scattering,” Optics Express 17 (2009) 21581. - R.-Y. He, C.-Y. Lin, Y.-D. Su, K.-C. Chiu, N.-S. Chang, H.-L. Wu, and S.-J. Chen*, “Imaging live cell membranes via surface plasmon-enhanced fluorescence and phase microscopy,” Optics Express 18 (2010) 3649. - W.-S. Kuo, C.-N. Chang, Y.-H. Chien, Y.-T. Chang, S.-J. Chen, and C.-S. Yeh, “Near-infrared Au nanorods in imaging, photodynamic therapy, and hyperthermia of malignant cells,” Angewandte Chemie, 2010 (accepted).

CURRICULUM VITAE C.H. Hsieh (謝清河) Clinical Medicine and Biomedical Engineering, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6- 2353535 ext.3653, 3656; Fax: +886-6- 2353535 ext.3653; E-mail: [email protected]

1. Educations 1999~2003 1985~1992

Department of Bioengineering, University of Washington, Seattle, WA, USA, Ph.D. Kaohsiung Medical College, Kaohsiung, Taiwan, M.D.

3. Professional Experiences 2006.9~ 2006.8~

Cardiovascular Surgery, NCKU Hospital, Attending Surgeon Institutes of Clinical Medicine and Biomedical Engineering, and Department of Surgery, National Cheng Kung University, Assistant Professor

2004.2~2006.7 Harvard Medical School/MIT, Boston, MA, USA, Research fellow 1999~2003 University of Washington, Seattle, WA, USA, Ph.D. (Bioengineering) 1996~1999 Cardiovascular surgery, National Taiwan University Hospital, Taipei, Taiwan, Senior & Chief Resident 1994~1996 Chang-Gang Memorial Hospital, Kaohsiung, Taiwan, Resident in Surgery 1992~1994 Tong-In Military Hospital, Tong-In, Taiwan, Military Doctor 1985~1992 Kaohsiung Medical College, Kaohsiung, Taiwan, M.D.

4. Fields of Specialty - Cardiovascular Development and Regeneration - Tissue Engineering, Nanotechnology - Stem Cell Biology - Controlled Drug Delivery and Transgenic Animal Model 5. Major awards and honors -

Postgraduate scholarship, Department of Bioengineering, U. of Washington, Seattle Postdoctoral fellowship, American Heart Association Finalist, Melvin L. Marcus Young Investigator Award in Cardiovascular Science, American Heart Association Finalist, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum

6. List of Recent Selected Publications (* corresponding author) - Chan SSK, Shueh YZ, Liu YW, Hsieh PC*. “Harnessing endogenous intra- and extra-cardiac stem cells for cardiac regeneration – hope or hype?”. Drug Discovery Today: Therapeutic Strategies. 2009; In press. - Chiu CT, Wang SP, Shieh DB, Ho CC, Cheng FY, Su CH, Chiu HC, Yeh CS*, Hsieh PC*. “Functional Nanoparticles in Biomedical Applications”. J Nanosci Nanotechno. 2009; In press. - Chan SK, Hsueh YZ, Bustamante N, Hsieh PC*. “A genetic fate-mapping approach to study cardiomyocyte replenishment after myocardial injury”. Method Mol Biol. 2009; In press. - Levkau B, Schäfers M, Wohlschläger J, Lipinski K, Keul P, Hermann S, Kawaguchi N, Hsieh PC, Ou Y, Mehrhof F, Kirchof P, Fabritz L, Heusch G, Schmid KW, Conway EM, Baba HA. “Survivin modulates cardiac function by determining the total number of cardiomyocytes.” Circulation 2008; 117:1583-1593. - heng FY, Wang SP, Su CH, Tsai TL, Wu PC, Shieh DB, Chen JH, Hsieh PC*, Yeh CS*. “The Nano-Sized PLGA Particles without Polymer Stabilizer Serving as Multimodal Biomedical Probes”. Biomaterials 2008;29:2104-2112. - Wang CC, Chen CH, Lin WW, Hwang SM, Hsieh PC, Lai PH, Yeh YC, Chang Y, Sung HW. “Direct Intramyocardial Injection of Mesenchymal-Stem-Cell Sheet Fragments Improves Cardiac Functions after Infarction”. Cardiovac. Res. 2008;77:515-524. - Hsieh PC, Segers VFM, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins F, Lee RT. “Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes following injury”. Nat Med..2007;13:970-974. (Cover story) - Engel FB, Hsieh PC, Lee RT, Keating MT.“ FGF1/p38 Inhibitor Therapy Induces Cardiomyocyte Mitosis, Reduces Scarring and Rescues Function after Myocardial Infarction.” Proc Natl Acad Sci U S A. 2006;103:15546-15551. - Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT. “Local Controlled Intramyocardial Delivery of PDGF Improves Post-Infarction Ventricular Function without Pulmonary Toxicity”. Circulation. 2006;114:637-644. - Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. “Local Myocardial IGF-1 Delivery with Biotinylated Peptide Nanofibers Improves Cell Therapy for Myocardial Infarction.” Proc Natl Acad Sci U S A. 2006;103:8155-8160. - Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT. “Controlled Delivery of PDGF-BB for Myocardial Protection Using Injectable Self-Assembling Peptide Nanofibers”. J Clin Invest. 2006;116:237-248. (BBC reported) - Hsieh PC, Kenagy RG, Mulvihill ER, Jeanette JP, Wang X, Chang CM, Yao Z, Ruzzo WL, Justice S, Hudkins KL, Alpers CE, Berceli S, Clowes AW. “BMP4: Potential Regulator of Shear Stress-Induced Graft Neointimal Atrophy”. J Vasc Surg. 2006;43:150-158.

- Hsieh PC, Davis ME, Likowski LK, Lee RT. “Endothelial-Cardiomyocyte Interactions in Cardiac Development and Repair.” Annu Rev Physiol. 2006;68:51-66. - Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT. “Custom Design of the Cardiac Microenvironment with Biomaterials.” Circ Res. 2005;97:8-15.

Name: Jenny Que (郭珍妮)

Date of Birth: 8th, Feb., 1959

Institute: Che Mei Medical Center Dept. of Radiation Oncology

Title: Attending Physician

Tel: +886-6-2820048

Address: 901, Chung Hwa Road, Yong Kang City 701, Taiwan Education: Ph.D., School of Medicine, Far Eastern University, Philippines

1976 - 1985

Professional Experience: Attending Physician, Dept. of Radiation Oncology, Chi Mei Medical Center 1996~ Attending Physician, Dept. of Radiation Oncology, National Cheng Kung University Hospital 1992-1996 Resident Doctor, Dept. of Radiation Oncology, National Cheng Kung University Hospital 1989-1992 Research Projects: 1. The Therapeutic Effect of Aloe-vera gel on Radiation-induced skin toxicity 奇美醫院研究專題計畫；計畫編號：CMFHR9219 2.

Exploring the role of nitric oxide and cylo-oxygenas 2 (COX-2) in irradiating hypoxic cervical cell lines 奇美-成功大學院際研究專題計畫；計畫編號：010; 920101-921231

List of Recent Selected Publications: 1. Primary Angiosarcoma of breast Yu-Wei Lin, Jenny Que, Chien-Feng Li, Kue-Li Lin, Li-Ching Lin; Therapeutic Radiology and Oncology Vol.16 No.2, p. 99-108, March 2005 2. A Novel Long-acting Analgesic Buphrenorphine Palmitate in Rats Jenny Que, Li-Ching Lin, Shynn-Yeu Liu, Chin-Chen Chu, Kuo-Sheng Liu, Shung-Tai Ho, Jhin-Joung Wang; Acta Anaesthesiol Taiwanica 43:11-16, 2005 3. Radiotherapy for the Treatment of Giant Cell Tumor of the Spine: A Report of Cases and Review of the Literature Jenny Que, Cheng-Hsing Kao, Tsung-Chia Tsai, Li-Ching Lin,Kuei-Li Lin, Forn-Chia Lin; Therapeutic Radiology and Oncology Vol.12 No.1, p. 67-72, March 2005 4.

5.

Novel Buprenorphine Ester- Buprenorphine Pivalate- Had a Long acting Antinociceptive Effect in Rats Cheng-Hsing Kao, Shynn-Yeu Liu, Jenny Que, Li-Ching Lin Shung-Tai Ho, Jhin-Joung Wang; accepted by 台灣外科醫學雜誌 2005 in press.

Exploring the role of nitric oxide and cylo-oxygenas 2 (COX-2) in irradiating hypoxic cervical cell lines Helen H.W.Chen, Jenny Que et al; accepted by Int. J Radia Onco Biol Physics 2005 In press 6. Breast Metastases from Nasopharyngeal carcinoma: a case report and literature review Jenny Que, Huang Chien-Tai, Chuang Shih-Sung, Lin Li-Ching, Lin Kue-Li; Chinese J Radiology Vol.28, No.5, p.323-327, October 2003 7. 第三級多葉準直儀臨床劑量特性之量測 林賢岳 林立青 莊克士 王仲榮 郭珍妮 阮國榮 丁慧枝 黃英明; Kaohsiung J Med Sci Oct. 2002

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Vol. 18 No.10 Interruption of Post-Radiotherapy follow-up in cancer patient Kuei-Li Lin, Jenny Que, Lin-Li Ching, Forn-Chia Lin, Mei-Chi Lin; Therapeutic Radiology and Oncology Vol. 11, No.3, p.151-156, September 2004 Small Cell Neuroendocrine Carcinoma of Ethmoid sinus: case report and literature Review Forn-Chia Lin, Li-Ching Lin, Chang-Chuan Su, Kuei-Li Lin, Jenny Que; Therapeutic Radiology and Oncology Vol.10, No.3, p.175-179, September 2003 Primary Brain Lymphoma: a Report of Eight Cases from a Medical Center in Southern Taiwan Shih-Sung Chuang, Po-shing Lee, Ching-Nan Lin, Tsung-Chia Tsai, Chung Ching Chio, Jenny Que, Chien-Tai Huang; Chinese Medical Journal (Taipei)2002; 65:172-179 Choroid Plexus Carcinoma of the Lateral Ventrical: Case report and Review Jenny Que, Lin Ching-Nan, Lin Li-Ching, Lin Kuei-Li; Therapeutic Radiology and Oncology Vol.8, No.1, p.55-59, March 2001 A Study on the Mould Room Potential Hazards and Safety Precautions Li-Ching Lin, Tien-Lung Ko, Ing-Ming Hwang, Yu-Ying Chao, Jenny Que, Chin-Jen Hsu, Shan-Yeh Lin; J Radiologic Tech. 25:237-246, 2001 Does bowel preparation improve the quality of abdominal gallium scintigraphy? J-F. Hsieh, J. Que, S.C. Tsai, K-Y. Cheng, W.Y. Lin, S.J.Wang; Nuclear Medicine Communications, 2000, 21, 1033-1036 A Study on the PDD Modification of Physical and Enhanced Dynamic Wedges Shen-Yeh Lin, Jenny Que, Ing-Ming Hwang, Ming-Yu Huang, Jen-Yang Tang, Yu-Hei Ho, Yi-Liang Chang; Therapeutic Radiology and Oncology 1999; 6; 01-308 A Measurement on the Transmission Factors of Dynamic Wedges Ing-Ming Hwang, Jenny Que, Helen H.W. Chen, Yu-Wen Wang; Therapeutic Radiology and Oncology Vol.4, No.1, p. 45-48, May 1997 The Dosimetry Characteristics of Leipzig Applicators Ing-Ming Hwang, Jenny Que, Helen H.W.Chen, Yu-Wen Wang; Therapeutic Radiology and Oncology Vol.4, No.2, p.133-137, June 1997 Nucletron Micro-Selectron source Renew Acceptance Test- The experience in NCKUH Ing-Ming Hwang, Jenny Que, Helen H.W.Chen, Yu-Wen Wang; Therapeutic Radiology and Oncology Vol.3, No.4, p.239-244, December 1996 A Study on the Dosimetry of Irregular Electron Fields Ing-Ming Hwang, Helen H.W.Chen, Jenny Que, Yu-Wen Wang; Therapeutic Radiology and Oncology Vol.3, No.3, p.193-198, September 1996 Technique of Total Body Irradiation used in NCKUH Helen H.W.Chen, Henry W.C Leung, Yeong-Fang Kuo, Ing-Ming Hwang, Jenny Que,Yu-Wen Wang; Therapeutic Radiology and Oncology Vol.3, No.2, p.93-99, June 1996 Nasopharyngeal Carcinoma: The Time Interval of Recurrence and Distant Metastasis Jenny Que, Shu-Chen Huang, Henry W.C. Leung, Louis T. Lai; Chinese J. Radiology Vol.18, No.1, p.1-10, March 1993

Curriculum Vitae Sheng-Hao Tseng Department of Electro-optical Engineering, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6-2757575 ext. 63925; E-mail: [email protected] 1. Education: Dec. 2006 Beckman Laser Institute at University of California, Irvine, Ph.D. Jun. 1999 Institute of Electro-optical Engineering, National Taiwan University, M.S. Jun. 1997 Department of Electrical Engineering, National Tsing-Hua University, B.S. 2. Professional Experiences: Feb. 2009 – present Assistant Professor, Department of Electro-Optical Engineering, National Cheng-Kung University Mar. 2007 – Dec. 2008 Postdoctoral Fellow, Methods and Models Development, Johnson & Johnson Consumer & Personal Products Worldwide 3. Fields of Specialty: -Diffuse Optics -Skin Optics 4. Patent: Tseng, Sheng-Hao, Durkin, A. J., “METHOD AND APPARATUS FOR QUANTIFICATION OF OPTICAL PROPERTIES OF SUPERFICIAL LAYERS”; United States Patent 7304724. 5. Consulting: 2005-2006 Masimo Corporation, 40 Parker, Irvine, CA 92618, USA 6. Refereed Journal Articles: - “Chromophore Concentrations, Absorption and Scattering Properties of Human Skin In-vivo”, Sheng-Hao Tseng, Paulo Bargo, Anthony Durkin, and Nikiforos Kollias, Optics Express, 17(17), 14599-14617, (2009). -

“Investigation of a probe design for facilitating the uses of the standard photon diffusion equation at

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short source-detector separations: Monte Carlo simulations”, Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, and Anthony J. Durkin, Journal of Biomedical Optics, 14(5):054043, (2009). “In-vivo Determination of Skin Near-Infrared Optical Properties Using Diffuse Optical Spectroscopy”, Sheng-Hao Tseng and Anthony J. Durkin, Journal of Biomedical Optics, 13(1):014016, (2008).

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“Determination of Optical Properties of Superficial Volumes of Layered Tissue Phantoms”, Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, and Anthony J. Durkin, IEEE Transactions on Biomedical Engineering, 55(1), 335-339, (2008).

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“Quantitative Spectroscopy of Superficial Turbid Media,” Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, Bruce J. Tromberg, Anthony J. Durkin, Optics Letters, 30(23), 3165-3167, (2005).

Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME

POSITION TITLE

Matthew O'Donnell

Frank & Julie Jungers Dean of Engineering

eRA COMMONS USER NAME

odonnel EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE (if applicable)

INSTITUTION AND LOCATION

University of Notre Dame, Notre Dame, IN University of Notre Dame, Notre Dame, IN

B.S. Ph.D.

YEAR(s)

1972 1976

FIELD OF STUDY

Physics Physics

A. Positions and Honors Professional Experience: 1972-1976 Graduate Research & Teaching Fellow in Physics, University of Notre Dame, Notre Dame, IN 1976-1978 Postdoctoral Fellow in Physics, Washington University, St. Louis, MO 1978-1980 Senior Research Associate in Physics and Research Instructor in Medicine, Washington University, St. Louis, MO 1984-1985 Research Fellow in Electrical Engineering, Yale University, New Haven, CT 1980-1990 Physicist, Corporate Research and Development Center, General Electric Company, Schenectady, NY 1990-2006 Professor, Electrical Engineering and Computer Science Dept., University of Michigan, Ann Arbor, MI 1998-2006 Professor and Chair, Biomedical Engineering Dept., University of Michigan, Ann Arbor, MI 1998-2006 Jerry W. and Carol L. Levin Professor of Engineering, University of Michigan, Ann Arbor, MI 2006-present Frank & Julie Jungers Dean of Engineering, University of Washington, Seattle, WA 2006-present Professor, Bioengineering Department, University of Washington, Seattle, WA Honors and Awards: B.S. with Honors, Notre Dame, 1972; Best Paper Award, Medical Physics, 1984; Best Paper Award, Medical Physics, 1985; Whitney Award 1990, Internal GE Research Award; Whitney Award 1991; Teaching Awards: EECS Dept. - 1995, College of Engineering – 1996, Univ. of Mich.; Research Award, BME Dept., Univ. of Mich., 1997; Achievement Award, IEEE Ultrasonics, Ferroelectric, and Frequency Control Society, 2007; Distinguished Alumni Award, University of Notre Dame, 2009; IEEE, Fellow; AIMBE, Fellow; National Academy of Engineering, Member B. Selected Peer-Review Publications Most Recent Archival Publications (2009): D.N. Stephens, M. O’Donnell, K.E. Thomenius, A. Dentinger, D. Wildes, P. Chen, K.K. Shung, J. Cannata, P.T. Khuri-Yakub, O. Oralkan, A. Mahajan, K. Shivkumar, and D. J. Sahn, “Experimental Studies with a Nine French Forward-Looking Intracardiac Imaging and Ablation Catheter,” Journal of Ultrasound in Medicine 28, pp. 207-215 (2009). R. Olafsson, R.S. Witte, C. Jia, S.W. Huang, K. Kim, and M. O’Donnell, “Cardiac Activation Mapping using Ultrasound Current Source Density Imaging (UCSDI),” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 3, pp. 565-574 (2009). S. Ashkenazi, Y. Hou, S-W Huang, T. Buma, and M. O’Donnell, “High Frequency Optoacoustic Transducers for Ultrasonic and Photoacoustic Imaging,” Photoacoustic Imaging and Spectroscopy, Optical Science and Engineering 143 (Chapter 18), CRC Press, ISBN 978-1-4200-5991-5, pp. 223-238 (2009). S.Y. Emelianov, Pai-Chi Li, and M. O’Donnell, “Photoacoustics for Molecular Imaging and Therapy,” Physics Today 62, no. 5, pp. 34-39 (2009).

PHS 398/2590 (Rev. 09/04)

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Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

Y. Petrank, L. Huang, and M. O’Donnell, “Reduced Peak Hopping Artifacts in Ultrasonic Strain Estimation Using the Viterbi Algorithm,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 7, pp. 1359-1367 (2009). L. Huang, Y. Petrank, S.W. Huang, C. Jia, and M. O'Donnell, “Phase Rotation Methods In Filtering Correlation Coefficients For Ultrasound Speckle Tracking,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 56, no. 7, pp. 1368-1382 (2009). S. W. Huang, J.F. Eary, C. Jia, L. Huang, S. Ashkenazi, and M. O’Donnell, “Differential-Absorption Photoacoustic Imaging for Contrast Enhancement,” Optics Letters 34, no. 16, pp. 2393-2395 (2009). Other Publications(selected from over 325): M. O'Donnell, J.T. Wang, and H.A. Blackstead, "Magnetoelastic excitations in single crystal gadolinium", Phys. Rev. Letters 36, pp. 606 (1976). M. O'Donnell, E.T. Jaynes and J.G. Miller, "General relationships between ultrasonic attenuation and dispersion", J. Acoust. Soc. Am. 63, pp. 1935 (1978). M. O'Donnell, "NMR Blood Flow Imaging Using Multi-Echo, Phase Contrast Sequences", Med. Phys. 12 59-64 (1985). S.W. Flax and M. O'Donnell, "Phase Aberration Correction in Medical Ultrasound: Basic Principles", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control UFFC-35, pp. 758-767 (1988). M. O'Donnell, A.R. Skovoroda, B.M. Shapo and S.Y. Emelianov, "Internal displacement and strain imaging using ultrasonic speckle tracking," IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control UFFC-41, pp. 314-325 (1994). M. Karaman and M. O’Donnell, “Subaperture Processing for Ultrasonic Imaging”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control UFFC-45, pp. 126-135 (1998). K.W. Hollman, S.Y. Emelianov, J.H. Neiss, G. Joytan, G.J.R. Spooner, T. Juhasz, R.M. Kurtz, and M. O’Donnell, “Strain Imaging of Corneal Tissue with an Ultrasound Elasticity Microscope”, Cornea 21, pp. 6873 (2002). W.F. Weitzel, K. Kim, J.M. Rubin, R.C. Wiggins, H. Xie, X. Chen, S.Y. Emelianov, M. O’Donnell “Feasibility of Applying Ultrasound Strain Imaging to Detect Renal Transplant Chronic Allograft Nephropathy”, Kidney International 65, pp. 733-736 (2004). K. Kim, A. Agarwal, S-W Huang, M.F. Denny, M.J. Kaplan, S. Ashkenazi, M. O’Donnell, and N.A. Kotov, “Photoacoustic Imaging of Early Inflammatory Response Using Gold Nanorods,” Applied Physics Letters 90, Article # 223901 – 3 pages (2007). S.-W. Huang, S.-L. Chen, T. Ling, A. Maxwell, M. O’Donnell, L.J. Guo, and S. Ashkenazi, “Low-noise Wideband Ultrasound Detection Using Polymer Microring Resonators,” Applied Physics Letters 92, Article # 193509 – 3 pages (2008). R. Olafsson, R.S. Witte, S-W Huang and M. O’Donnell, “Ultrasound Current Source Density Imaging,” IEEE Transactions on Biomedical Engineering 55, pp. 1840-1848 (2008). D.N. Stephens, J. Cannata, R. Liu, J. Zhao, K. K. Shung, H. Nguyen, R. Chia, A. Dentinger, D. Wildes, K.E. Thomenius, A. Mahajan, K. Shivkumar, K. Kim, M. O’Donnell, A. Nikoozadeh, O. Oralkan, P.T. KhuriYakub, and D. J. Sahn, “Multifunctional Catheters Combining Intracardiac Ultrasound Imaging and Electrophysiologiy Sensing,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 55, no. 7, pp. 1570-1581 (2008). Y. Hou, J.-S. Kim, S. W. Huang, S. Ashkenazi, L.J. Guo, and M. O’Donnell, “Characterization of a Broadband All-Optical Ultrasound Transducer – from Optical and Acoustical Properties to Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 55, no. 8, pp. 1867-1877 (2008). R.S. Witte, T. Hall, R. Olafsson, S-W Huang, and M. O’Donnell, “Inexpensive Acoustoelectric Hydrophone for Mapping High Intensity Ultrasonic Fields,” Journal of Applied Phyiscs 104, Article # 054701 – 3 pages (2008). S. W. Huang, Y. Hou, S. Ashkenazi, and M. O’Donnell, “High Resolution Ultrasonic Imaging Using an Etalon Detector Array,” Applied Physics Letters 93, Article # 113501 – 3 pages (2008). Patents (selected from 58): M. O’Donnell, "Coded Excitation for Transmission Dynamic Focusing of Vibratory Energy Beam", U.S. Patent # 5,014,712, issued 5/14/91. M. O’Donnell, “Method and System to Create and Acoustically Manipulate a Microbubble”, U.S. Patent # 7,549,985, issued 06/23/09. PHS 398/2590 (Rev. 09/04)

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O’Donnell, Matthew

C. Research Support Ongoing Research Support RO1 HL082640 (Subcontract to Yale: P.I. James Duncan) NIH LV Strain Quantification for 4D Echocardiography Role: PI of subcontract

6/1/06-5/31/11

This is a Bioengineering Research Partnership (BRP) to explore new data acquisition and signal processing methods for real-time elasticity imaging of the heart using 4D echocardiographic RF data. RO1 HL067647 (Subcontract to OHSU: P.I. David Sahn) NIH High Frequency Ultrasound Arrays for Cardiac Imaging Role: PI of subcontract

9/1/08-8/31/13

This is a Bioengineering Research Partnership (BRP) to explore intracardiac catheters integrating ultrasound imaging and electrophyiological mapping and therapy.

Completed Research Support RO1 EB003455 (Matthew O’Donnell, PI) NIH Optoacoustic Transduction for High-Frequency Ultrasound Role: PI

7/1/05-6/30/09 – transferred 9/1/06

Explore integrated optoacoustic device for a guidewire imaging array. R21 EB003449 (Matthew O’Donnell, PI) NIH Ultrasonic Imaging of LIOB in Dendrimer Nanocomposites Role: PI

4/1/05-3/31/07 – transferred 9/1/06

Explore molecular imaging using dendrimer nanocomposites. R21 EB003451 (Matthew O’Donnell, PI) NIH Microwave Induced Thermal Imaging Role: PI

8/1/05-7/31/07 – transferred 9/1/06

Explore thermal strain imaging to differentiate water-bearing from lipid-bearing tissue. RO1 CA91713 (Subcontract, P.I. Paul Carson) NIH Combined Digital X-Ray and Ultrasound Breast Imaging Role: PI of subcontract

9/27/02-8/31/07 – transferred 9/1/06

This is a Bioengineering Research Partnership (BRP) to explore an integrated mammography and ultrasound system providing tissue elasticity information. T32 DE07057-26 (Paul Krebsbach, PI) NIH Tissue Engineering and Regeneration Role: Co-investigator

7/1/02-6/30/07 – transferred 9/1/06

Training grant in tissue engineering and regenerative medicine. PHS 398/2590 (Rev. 09/04)

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Principal Investigator/Program Director (Last, First, Middle):

O’Donnell, Matthew

1 R21 EB004933-01 (L. Jay Guo, PI) NIH Ultrasound Imaging Using Photonic Microring Resonators Role: Co-investigator

4/1/05-3/31/07– transferred 9/1/06

Explore novel integrated optical device for high frequency ultrasound imaging. 1 R21 EY015876-01 (Kyle Hollman, PI) NIH Bubble Based Acoustic Force Elasticity for Presbyopia Role: Co-investigator

4/1/05-3/31/07– transferred 9/1/06

Explore new technology to measure tissue elasticity by deforming tissue with acoustic radiation force applied to femtosecond laser produced microbubbles.

PHS 398/2590 (Rev. 09/04)

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CURRICULUM VITAE Nan-Shan Chang (張南山) Institute of Molecular Medicine, National Cheng Kung University Tainan 701, Taiwan Tel: +886-6- 2353535 ext:5268; Fax: +886-6- 2095845; E-mail: [email protected]

1. Educations 1980.8 1974.9

Medical Univ. of S. Carolina Charleston, S. Carolina, Ph.D. National Taiwan Normal Univ. Taipei, Taiwan, B.S.

2. Professional Experiences 2009.1~

Upstate Medical University at Syracuse, Department of Neuroscience and Physiology, Adjunct Professor 2006.11~ National Cheng Kung University Medical College, Institute of Molecular Medicine, Professor 1995.7~2005.12 Guthrie Research Institute, Laboratory of Molecular Immunology & Protein/Peptide, Associate Scientist and Laboratory Director 1989.7~1995.6 Guthrie Research Institute, Laboratory of Molecular Immunology & Protein/Peptide, Assistant Scientist and Laboratory Director 1991.1~ GlycoMed Research Incorporated, Hastings-on-Hudson, NY, Consultant

3. Fields of Specialty - Mechanism of apoptosis: Role of WW domain-containing oxidoreductase WOX1 in regulation of mitochondrial apoptosis and cancerous progression of breast, prostate, and brain. - Signaling network: Elucidating signaling network that controls cell growth, differentiation and death. -Naturally occurring small-size anticancer proteins: Cloning, database mining and characterization of rare small-size proteins in inducing cancer cell death. 4. List of Recent Selected Publications (* corresponding author) - Chen ST, Chuang JI, Cheng CL, Hsu LJ, Chang N-S (2005) Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WOX1 in vivo. Neuroscience, 130, 397-407. - Chang N-S, Schultz L, Hsu LJ, Lewis J, Su M, Sze CI (2005) 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. Oncogene, 24, 714-723. - Hsu LJ, Schultz L, Mattison J, Lin YS, Chang N-S (2005) Cloning and characterization of a small size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun, 327, 415-423. - Lai FJ, Cheng CL, Chen ST, Wu CH, Hsu LJ, Lee JY, Chao SC, Sheen MC, Shen CL, Chang N-S, Sheu HM (2005) WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo. Clin Cancer Res, 11, 5769-5777. - Chang N-S, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q (2005) WOX1 is essential for TNF-, UV light-, staurosporine-, and p53-mediated cell death and its tyrosine 33 phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem, 280, 43100-43108. - Hong Q, Kuo E, Schultz L, Boackle RJ, Chang N-S (2007) Conformationally altered hyaluronan restricts complement classical pathway activation by binding to C1q, C1r, C1s, C2, C5 and C9, and suppresses WOX1 expression in prostate DU145 cells. Int. J. Mol. Med. 19, 173-179. - Chang N-S, Hsu LJ, Lai FJ, Sheu HM, Lin YS (2007) WW domain-containing oxidoreductase: tumor suppressor, promoter, or both? Trends in Mol. Med. 13, 12-22.* - Hong Q, Hsu LJ, Schultz L, Pratt N, Mattison J, Chang N-S (2007) Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol. Biol. 8, 50 - Lo CP, Hsu LJ, Li MY, Hsu SY, Chuang JI, Tsai MS, Lin SR, Chang N-S, Chen ST (2008) MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1. Euro. J. Neurosci. 27, 1634-1646. - Hsu LJ, Hong Q, Schultz L, Kuo E, Lin SR, Lee MH, Lin YS, Chang N-S (2008) Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cell. Signal. 20, 1303-1312. - Chen ST, Li MY, Hsu LJ, Lo CP, Cheng CL, Tsai MS, Lin SR, Lee MH, Chang JY, Subhan D, Pugazhenthi S, Sze CI, Chang N-S (2009) Axotomy induces activation of tumor suppressor WWOX/WOX1 and interaction with transcription factors c-Jun and ATF/CREB in neurons of dorsal root ganglion. J. Neurosci. Submitted. - He RY, Chang CH, KC, Chang N-S, Su YD, Chen SJ (2009) Surface plasmon-enhanced two-photon fluorescence microscopy for live cell membrane imaging. Optics Express 17, 5987-5997. - Hong Q, Sze CI, Schultz L, Lin SR, Lee MH, He RY, Lo CP, Chang JY, Hsu LJ, Chen SJ, Boackle RJ, Chang N-S (2009) Complement C1q activates tumor suppressor WWOX to kill prostate cancer cells. PLoS ONE, 4, e5755. - Hsu LJ, Chen ST, Schultz L, Van Moer K, Heath J, Li MY, Lai FJ, Hong H, Lin YS, Chang N-S (2009) Cell surface hyaluronan-binding protein Hyal-2 is a cognate receptor for transforming growth factor β1. J. Biol. Chem. 284, 16049-16059.

- Lee MH, Lin SR, Chang N-S (2009) TGF-β1-induced TIAF1 self-association leads to apoptosis. In Alzheimer’s & Parkinson’s Diseases: Advances, Concepts & New Challenges, Medimond International Proceedings (in press)

CURRICULUM VITAE Feng-Jie Lai (賴豐傑) Medical Dermatology, Chi-Mei Foundation Medical Center Tainan 701, Taiwan Tel: +886-6-2812811; Fax: +886-6-2515404; E-mail: [email protected]

1. Personal Information Birth: 1964.

2. Educations 1997.9 1994.9 1988.9 1984.9

Graduate Institute of Medicine, Kaohsiung Medical University, Ph.D. Post Baccalaureate Medicine, Kaohsiung Medical University, B.S. Institute of Anatomy and Cell Biology, National Yang-Ming University, M.S. Department of Life Sciences, National Cheng Kung University, B.S.

3. Professional Experiences 2006.8~ 2004.8~ 2001.7~2006.7 1992.8~1993.8 1990.7~1992.5 1989.8~1990.6

Dermatology, Chi Mei Medical Center, Attending Physician and Deputy Director Department of Nursing, National Tainan Institute of Nursing, Pluralism Assistant Professor Department of Dermatology, National Cheng Kung University Hospital, Resident Physician Department of Anatomy, National Yang-Ming University, Assistant R.O.C. Marine Corps School, Republic of China Marine Corps, Medical offer in Ensign Department of Anatomy, National Yang-Ming University, Assistant

4. Fields of Specialty -Dermatology -Oncology -Histology -Anatomy5. List of Recent Selected Publications (* corresponding author) - Lai FJ, Cheng CL, Chen ST, Wu CH, Hsu LJ, Lee JY, Chao SC, Sheen MC, Shen CL, Chang NS, Sheu HM. WOX1 Is Essential for UVB Irradiation Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo. Clin Cancer Res. 2005; 11(16):5769-77. ［SCI］ [IP: 5.715] (成杏醫學文 教基金會「2006 年優秀論文獎」) - Lai FJ, Hsin YC, Huang SC, Cheng CL, Hsin SC, Hsieh MC, Shin SJ. Down-Regulation of Adrenal Neuronal Nitric Oxide Synthase mRNAs and Proteins after Deoxycorticosterone Acetate-Salt Treatment in Rats. J Steroid Biochem Mol Biol. 2006; 101:197-203. ［SCI］ [IP: 2.866] - Lai FJ, Huang SS, Hsieh MC, Hsin SC, Wu CH, Hsin YC, Shin SJ. Upregulation of Neuronal Nitric Oxide Synthase mRNA and Protein inAdrenal Medulla of Water-deprived Rats. J Histochem Cytochem. 2005; 53(1):45-53. ［SCI］ [IP: 2.208] - Lai FJ, Hsieh MC, Hsin SC, Lin SR, Guh JY, Chen HC, Shin SJ. The cellular localization of increased atrial natriuretic peptide mRNA and immunoreactivity in diabetic rat kidneys. J Histochem Cytochem. 2002; 50(11):1501-8. 【SCI】 [IP: 2.208] - Lai FJ, Sheen MC, Sheu HM, Chai CY. Comparison of the Differences among Oral Verrucous Hyperplasia, Verrucous Carcinoma, and Squamous Cell Carcinoma by Silver-binding Nuclear Organizer Regions Stain and - Immunohistochemical Staining of Proliferating Cell Nuclear Antigen, Type IV Collagen, and Laminin. Dermatologica Sinica. 2006; 24:1-8. (中華皮膚科醫學雜誌論文獎『特優獎』) - Chang NS, Hsu LJ, Lin YS, Lai FJ, Sheu HM. WW domain-containing oxidoreductase: a candidate tumor suppressor. Trends Mol Med. 2007; 13: 12-22［SCI］ [IP: 5.505] - Lai FJ, Sheu HM, Lee JY, Cheng CL, Chen WC. Vesicular Pemphigoid with Circulating Autoantibodies Against 230 kDa and 180 kDa Proteins, and Additional Autoantibodies Against 97 kDa and 45 kDa proteins. Int J Dermatol, 2007; 46:206-9 ［SCI］ [IP:0.942] - Sheen MC, Sheu HM, Lai FJ, Lin SD, Wu CF, Wang YW, Lan CC. A huge verrucous carcinoma of the lower lip treated with intra-arterial infusion of methotrexate. Br J Dermatol. 2004; 151(3):727-9. ［SCI］[IP: 2.978] - Chao SC, Lai FJ, Yang MH, Lee JY. Mal de meleda in a taiwanese. J Formos Med Assoc. 2005; 104(4):276-8.［SCI］ [IP: 0.474] - Lai FJ, Sheu HM. Cardio-facio-cutaneous Syndrome – A Case Report-. Dermatologica Sinica. 2006; 24:132-6.

LIAO & ASSOCIATES 523 Pine Street, Suite 205, Seattle, WA 98101 Tel: (206) 343-9910

? Fax: (206) 343-0367

PAUL B. LIAO, Ph.D., P.E. President and Chief Executive Officer, LAA Holding Company,

KCM International, US Asia International Technologies Member, Board of Governors, Virginia Mason Medical Center, Seattle, Washington Former Chairman/Chief Executive Officer - KCM, Inc. Former Chairman - KCM International Inc. Former President - Omega Technologies, Inc. Former Chairman - Construction Management & Inspection, Inc. Former Chairman - Tt Infrastructure Northwest Group Former Director of Executive Board, Tetra Tech, Inc. Education:

BSCE, National Cheng Kung University, Tainan, Taiwan 1964 MSCE, Oklahoma State University, Stillwater, Oklahoma 1967 Ph.D. Environmental Engineering, University of Washington, ` Seattle, Washington 1971-72

Dr. Liao, former Chairman, Chief Executive Officer and Chief Financial Officer, oversaw and supervised the overall Tt/KCM company technical activities and corporate management. Dr. Liao is internationally recognized and respected for the development of innovative engineering techniques and his contribution to the state-of-the-art in bioengineering. His diverse experience includes water quality control and hatchery water supply systems, planning and designs of industrial and municipal water and wastewater systems, investigation/evaluation and design of air pollution control methods, and aquaculture/fisheries farming development and implementation. Dr. Liao had been principally responsible for many projects with capital costs over one billion dollars for pollution control and environmental engineering. He had researched and developed many systems and design formulas/criteria that have been popularly used worldwide. Dr. Liao was responsible for projects worldwide, including water and air pollution control, solid wastes, fisheries, biological systems, aquariums, oceanographic museums and laboratory research and development. He had been responsible for many projects in Egypt, China, Chile, Canada, India, Korea, Hong Kong, Kuwait, Sri Lanka, Brunei, Sabah, Indonesia, Puerto Rico, Malaysia, Tunisia, Taiwan, Guam, Singapore, El Salvador, Mexico, New Zealand, Saudi Arabia, Dominican Republic, West Africa, Ecuador, etc. Dr. Liao served as faculty member for the Graduate School of the University of Washington, both in the College of Engineering and the College of Fisheries. He lectured in USA, Taiwan, China, Dominican Republic and other countries, He presided technical sessions for many US national and international conferences. Dr. Liao served as a member of the Examination Committee for the American Environmental Engineers Academy.

Major Awards and Recognitions: 1.

Outstanding Alumni Most Achievement Award: National Cheng Kung University 2008.

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Distinguished Fellow Award: Oklahoma State University 2009 Laureate Award, University of Washington 2005. Dr. Paul B. Liao and Mei-Yea Liao Learning Room at Wing Luke Asia Museum, Seattle, Washington. Dr. Paul B. Liao and Mei-Yea Liao Surgical Center at Virginia Mason Medical Center, Seattle, Washington. Dr. Paul B. Liao and Mei-Yea Liao Room at Seattle Chinese Nursing Home.

Project Experience: During his professional career, he was involved in multiple-discipline projects including Wastewater facilities, Water systems, Solid waste management, Industrial Buildings, Air pollution control, Environmental assessments/impact Statements, Aquaculture (commercial farming), Fisheries, Aquariums, & Transit. Memberships: World Aquaculture Society Water Pollution Control Federation Air & Waste Management Association Air Pollution Control Association International Ozone Institute American Consulting Engineers Council American Society of Civil Engineers American Water Works Association American Fisheries Society American Academy of Environmental Engineers Hazardous Materials Control Resources Institute

Awards: Received the following awards as project leader and/or principal participant: Honor Award - Consulting Engineers Council of Washington LOTT Complex Wastewater Facilities Plan and Design, Olympia, Washington Honor Award (Top 15) - American Consulting Engineers Council LOTT Complex Wastewater Facilities Plan and Design, Olympia, Washington First Honor Award - Consulting Engineers Council of Washington Shelton Wastewater Treatment Plant, Shelton, Washington Honor Award - American Consulting Engineers Council Shelton Wastewater Treatment Plant, Shelton, Washington First Honor Award - Consulting Engineers Council of Washington Port Orchard Wastewater Treatment Plant, Port Orchard, Washington Honor Award - American Consulting Engineers Council Port Orchard Wastewater Treatment Plant, Port Orchard, Washington Honor Award - Consulting Engineers Council of Washington Enumclaw Wastewater Treatment Plant, Enumclaw, Washington Honor Award - American Consulting Engineers Council Enumclaw Wastewater Treatment Plant, Enumclaw, Washington

Grand Award - Consulting Engineers Council of Washington Warm Springs National Fish Hatchery, Oregon Grand Award - American Consulting Engineers Council Warm Springs National Fish Hatchery, Oregon Grand Award - Consulting Engineers Council of Washington Woods Hole Oceanographic Institute, Environmental Systems Laboratory, Massachusetts Honor Award (Top 10) - American Consulting Engineers Council Woods Hole Oceanographic Institute, Environmental Systems Laboratory, Massachusetts Grand Award - Consulting Engineers Council of Washington Seattle Aquarium, Seattle, Washington Grand Conceptor Award - American Consulting Engineers Council Seattle Aquarium, Seattle, Washington Engineer of the Year, 1995 - Chinese Institute of Engineers, U.S.A. Distinguished Environmental Services Award, 1995 - Overseas Chinese Environmental Engineers & Scientists Associations Outstanding Alumni, Civil Engineering - National Cheng-Kung University, Taiwan, R.O.C. National Museum of Marine Biology/Aquarium, Taiwan, R.O.C. Grand Award, 2001 National Consulting Engineers Council; Excellency Quality Achievement Award, National Public Works Commission, R.O.C.; Honor Award, Chinese Engineers Association, R.O.C.; Excellency Award, Ministry of Education, R.O.C.; Honor Award, Washington Consulting Engineers Council. Penghu Aquarium, Taiwan: Excellency Award from Taiwan Provincial Government

Professional Achievements: Dr. Liao had presided over several international technical conferences. Since 1979, he had acted as chairman, guest lecturer, panelist and committee member for the World Aquaculture Society, United Nations FAO, the Association of Conservation Engineers, the University of Washington, the Chongquing Institute of Architecture and Engineering in China, National Taiwan University, the Ministry of Economics of Taiwan, ROC, and the Air Pollution Control Subcommittee of the American Academy of Environmental Engineers. Dr. Liao was a board member of China Engineers Institute, Seattle Chapter. Dr. Liao was an Executive Board member of Tetra Tech, Inc., a national engineering firm of over 8,000 engineers, architects & scientists. Dr. Liao was a board member of Overseas Chinese Environmental Engineers and Scientists Association. Dr. Liao was Engineer of the Year in 1995 for U.S. Overseas Chinese Engineers, Seattle Chapter. Dr. Liao was founding member of NW National Cheng-Kung University Alumni Assoc.

Program Chairman: American Conservation Engineers Association, New Hampshire, 1972 World Aquaculture Society, Honolulu, Hawaii, 1977 World Aquaculture Society, Scavenger, Norway, 1982 World Aquaculture Society, Venice, Rome, 1984 World Aquaculture Society, Reno, Nevada, 1985

Special Consultant: Canadian Federal Government, Fish and Wildlife Department U.S. Sport Fisheries and Wildlife U.S. National Marine Fishery Services U.S. Corps of Engineers Numerous State Government Agencies and Private Companies Worldwide

Inventions, Development of Design Formulas and Systems: Fluidized Bed Sewage Sludge Incinerator Ion Exchange Bed Water and Wastewater Treatment System Sand Filter Air Scrubber System Submerged Biofilter, Upflow Filter, Horizontal Biofilter, Trickling Filter, Extended Aeration, Activated Sludge Process for Hatchery Water Reconditioning Biological Vegetation System for Sewage Treatment - Applied at several cities in Washington and Oregon Hatchery Water Buffering System Application of Pure Oxygen for Prawn Shrimp Culture Various Models for Hatchery Water Reuse Computer Models for Programming and Design of Fish Hatchery and Farming for a Variety of Species Pollution Control Methods for Fish Farming Several Engineering Design Formulas: Water and Wastewater Treatment, Solid Waste, and Air Pollution Control

Publications: Dr. Liao has prepared and published many engineering reports and technical papers. Typical papers include the following: "Technology Transfer and the Consulting Engineer," presented at the 1989 World Aquaculture Society Conference, Los Angeles, California, U.S.A.,” February 12-16, 1989. Coauthored with Greg G. Rice. “General Considerations for Marine Shrimp Farming,” presented at the Workshop on the Prospect of Aquaculture Development in Karang-Agung, Palembang, Indonesia, South Sumatra.” January 26-17, 1988. “The Emergence of China as a World Leader in Marine Shrimp Production,” presented at 19th Annual World Aquaculture Society Conference, Honolulu, Hawaii. January 4-8, 1988. Coauthored with Craig L. Paulsen. “Development and Potential for Shrimp Aquaculture in the People’s Republic of China,” presented at the 3rd Shrimp World Marketing Conference, Cancun, Mexico. November 8-12, 1987. “Innovative/Alternative Technology Applications for the Olympia Wastewater Treatment Plant,” presented at the Northwest Water Pollution Control Conference, Boise, Idaho. 1983. “Use of Natural Zeolites in Aquaculture,” presented at Zeo-Agriculture ’82 Conference in Rochester, New York, June 1-4, 1982. Part of this paper has been presented at the World Mariculture Society Annual Conference in Seattle, Washington, U.S.A. March 8-10, 1981.

“Treatment Units Used in Recirculation Systems for Intensive Aquaculture,” presented at the 1980 FAO Symposium, 1980, Stavanger, Norway. “Ion Exchange Systems for Water Recirculation,” presented at Bioengineering Symposium, Traverse City, Michigan, October 15-18, 1979. “Salmonid Carrying Capacity for Water Reconditioning Reuse System,” presented at World Mariculture Society Conference, Honolulu, Hawaii, January 22-26, 1979. “Ozone Disinfection for Olympia Wastewater Treatment Plant,” presented at the International Ozone Institute Ozone Symposium, May 23-25, 1978, Los Angeles, California. “A Wastewater Treatment Study for Skokomish Salmon Processing Plant,” presented at the 7th National Symposium on Food Processing Wastes, Atlanta, Georgia, April 7, 1976. Co-authored with S.S. Lin and Max Cochrane. “Evaluation of an Extended Aeration Process for Skokomish Salmon Processing Wastewater Treatment,” presented at PNPCA/Industrial Waste Conference, Seattle, Washington, October 18, 1976. “Salmon-Processing Wastewater Treatment.” Co-authored with P.A. Bissonnette and S.S. Lin. “Ammonia Production Rate and Its Application to Fish Culture System Planning and Design,” presented at the 25th Northwest Fish Culture Conference, Seattle, Washington, December 4-6, 1974. “Fluidized-Bed Sludge Incinerator Design,” Journal of Water Pollution Control Federation, 46, August 8, 1974. “Intensified Fish Culture Combining Water Reconditioning with Pollution Abatement,” Journal of Aquaculture, 3, 61-85. 1974. Co-authored with Ronald D. Mayo. “Nutrient Removal Using Aquaculture Systems,” prepared and published for Cities of Lacey, Olympia, Tumwater and Thurston County, Washington, 1973. “Sand Filter Air Scrubber,” presented at the PNWIS Annual Conference, Seattle, 1973. “Salmonid Hatchery Water Reuse Systems,” Journal of Aquaculture, 1:317-335, December 1972. Coauthored with Ronald D. Mayo. “Development of Hatchery Water Treatment Systems,” presented at the Eleventh Annual Conference of Conservation Engineers, New England Center for Continuing Education, Durham, New Hampshire, October 2-5, 1972. “Air Pollutant Emissions from Fluidized Bed Sewage Sludge Incinerators,” Water and Sewage Works, 119 (2): 68, February 1972. Coauthored with M.J. Pilat. “The Nitrification Process for Reconditioning Fish Hatchery Water,” presented at the 22nd Northwest Fish Cultural Conference, Portland, Oregon, December 2-3, 1971. “Water Requirements of Salmonids,” The Progressive Fish-Culturist, 33, 4, 210. 1971. “Pollution Potential of Salmonid Fish Hatcheries,” Water and Sewage Works, August 1970. “Salmonid Hatchery Wastewater Treatment,” Water and Sewage Works, 117, 12, 439. December 1970. "Motorcycle Emission Control," Presented at 1994 Taiwanese Motorcycle Manufacturers Annual Meeting, Taipei, Taiwan, December 20, 1993. "Lake Pollution - Prevention and Restoration," Presented at Taiwan-China Environmental Protection Workshops, National Taiwan University, Taipei, Taiwan, December 21-26, 1993. Co-authored with Harry L. Gibbons, Ph.D. "KCM/KCMI's Work Experience in Taiwan," Presented at U.S. Dept. of Commerce International Trade Administration Workshop for Taiwan New Market Opportunities The six-year Development Plan, February 19, 1993. Westin Hotel, Seattle, Washington.

"International Cooperation to Improve Taiwan Environment," Presented at 4th International Conference of Asia Exports, Portland, Oregon, May 7-8, 1992. "Expansion and Upgrade of West Point Treatment Plant, Municipality of Metropolitan Seattle", presented at Third Taiwan-China Environmental Conference, Hsinghua University, Bejing, China. August 29, 1995. "Yana River Salmon Hatchery, Magadan, Russia", presented at 1997 World Aquaculture Society's Annual Conference, February 19-23, 1997, Seattle, Washington. "Marine Fish Hatchery at Lake Jackson, Texas", presented at 1997 World Aquaculture Society's Annual Conference, February 19-23, 1997, Seattle, Washington. “River and Lake Pollution Control - River Basin Planning”, presented at 5th Mainland Taiwan Environmental Protection Academic Conference, May 24-30, 1998, Nanjig, China “Ozonation of Hatchery and Aquarium Water”, presented at 5th Mainland Taiwan Environmental Protection Academic Conference, May 24-30, 1998, Nanjig, China "Comprehensive Hazardous Flood Control Plan", presented at 7th Mainland Taiwan Environmental Protection Academic Conference, April 24-30, 2001 Wuhan, China.

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Advisor, Seattle Community Colleges Co-founder/sponsor of establishment of Environmental Annual Conference program between Taiwan and China in 1991 Donor of Scholarships for both Civil Engineering Dept. and Environmental Engineering Dept. of National Cheng Kung University. Endowment of Funds to University of Washington for perpetual collaboration program between University of Washington and National Cheng Kung University; and to finance perpetual scholarships for NCKU graduate students to pursue PhD at University of Washington. Assisted the City of Seattle to relocate over 100 homeless from Seattle Center Camping to Aloha Motor Hotel in 1991. Endowment of funds to Oklahoma State University for perpetual scholarship to benefit students from Taiwan Shu Te University for graduate studies. Assisted Taiwan representatives to enhance diplomatic, social and cultural relationships and activities in USA.