A LTM story in nanotechnology
D. Peyrade CNRS Research Director Team leader Micronanotechnology for Health Co-founder of Smart Force Technologies © LTM-CNRS c/o CEA-LETI, Grenoble David PEYRADE |
[email protected]
J. Cordeiro Président, co-founder Smart Force Technologies © SAS www.smartforcetechnologies.com ARC6 1 april 2016 1
Outline • LTM : The beginning of the story…. • Smart Force Technologies ©
• The future for LTM & SFT
David PEYRADE |
[email protected]
ARC6 1 april 2016 2
The boom of colloidal matter •
Mastering chemical synthesis - Complexity of materials (low cost)
•
Physics properties are specifics - S/V – confinement elect/photon
•
How to integrate this material?
Miroelectronic technologie not suitables Litho, etch, deposition… Bawendi
-
Broad range of application domains Particles brownian motion
Strategies to exploit particles physical properties Interfaces Assembly
Outside forces Manipulate 3 FGRAD V opt/ m Kopt / CM E 2 2 Particle /Milieu polarisable Champ électrique alternatif / Electromag. Attraction/Repulsion
t=10s T=25°C
Attraction
eau
Particule PS 500 nm Particules 1 nm -10 µm Force [10 nN …pN]
Hydrodynamic, Capillary, gravitationnal David PEYRADE |
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Electrocinetic
Optic ARC6 1 april 2016 3
Thermodynamic assembly : From physics to technology Innovations
Thermodynamic
Illustrations Goutte Goutte
Q ~100ml/min 10 µm 10 µm
Substrat Substrat
-Exploit hydrodynamic force Aspiration flux -Maximise capillary forces surface functionnalisation -Mastering the front displacement fluidic cell
2 Patents : Principle/cell
Préconcentration
Assemblage 5 µm
1µm Polystyrène
3 PhDs, 3 ANR, 11 RICL
Filling factor>99%
>1 Million /cm2
1 European demonstration (2006) GenericTechnology (material/substrate) to integrate collectivly colloidal particles Thermodynamic assembly: An elementary technology inserted in micro-nanotechnologies (litho, etch, NIL…) David PEYRADE |
[email protected]
ARC6 1 april 2016 4
Application domains Particles size: 5 nm à 10 µm
TICs
Plasmonic
Photonic
Magnétism
1 µm
200 nm
Nanoantenna (dimers/chains)
Guiding/confinement focalisation sub-l
Plasmons 3D
Coll. CEMES ITODYS, ESPCI …
Biology
5nm domains
White light emitters
2 ANR 11 RICL (APL, JVSTB, J. Phys Chem C…) 2 Patents 2 thèses
Molecular scale (nm)
Cellular scale(µm) S. epidermidis
15 µm
100 nm
Coll. LMGP
DNA combing
5 µm Coll. Clinatec
Exosomes (illness sentinel)
3 µm Coll. LETI
Bacteria 1 ANR 1 Carnot, 3RICL, 1 thèse
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Industrial transfert • SMART FORCE : Integration of colloidal particles on-chip From fundamental research to a commercial solution Fundamental research
Concept proof /Prototype
TRL 1
Operationnal system
Commercialization (LTM)
TRL 7
TRL 9
TRL 3
Unit
X3
X2
2011
ISA
Consommables
Microfluidic chamber
2006
1st sell
Functionnalised substrates
3 PhDs, 2 ANRs,11 RICL,2 Patents,3 prototypes
Stand conference
2015
• The « First step" team 2012-2015
D. Peyrade CNRS, LTM
M. Zelsmann CNRS,LTM
E. Picard CEA
K. Berton, CNRS,LTM
K. Berton, doct.,LTM
Human adventure (facts, skills…) Entrepreneurial model : organic growth David PEYRADE |
[email protected]
ARC6 1 april 2016 6
SMART FORCE: THE SOLUTION
David PEYRADE |
[email protected]
ARC6 1 april 2016 7
SMART FORCE SOLUTION Research activity Successfull companies experience : attocube Imina … Prototype commercial product Subcontractors : Atelier chartreuse Supernova… Intelligent microfluidic head
Marketing: product brochure ..booth Key opinion leader : conferences…
SMART FORCE
David PEYRADE |
[email protected]
ARC6 1 april 2016 8
PROMOTING SMART FORCE SOLUTION
Salon Nanotech, Japon 2014
Lyon, March 2015 MNE 2014, Lausanne
Meet new ecosystem : academic collaborators, distributors, start-up, industrial First sell Ready for the creation of Smart Force Technologies David PEYRADE |
[email protected]
ARC6 1 april 2016 9
Operationnal team SATT Grenoble
Julien CORDEIRO, PhD 2010-2013: Thèse LTM CFA, Optique, Prototypage 2012: Challenge First Step CEA 2014-2015: Projet Smart Force
Incubation: oct 2015
Olivier LECARME, PhD 2008-2011: Thèse LTM CFA, Optique, Informatique 2012-2014: Post-doc Sapporo Optique, Cellule solaires 2014-2015: Projet Smart Force
Smart Force Technologies is a young company born from French laboratories LTM-CNRS & CEA Smart Force Technologies © SAS www.smartforcetechnologies.com
Scientific advisor D. Peyrade LTM-CNRS E. Picard CEA
Julien CORDEIRO |
[email protected] David PEYRADE |
[email protected] www.smartforcetechnologies.com
ARC6 1 april 2016 10
Natural evaporation
Controlled evaporation
1 µm
-
1 µm
Predetermined and reproductible deposition
Individual caracterisation of structural and physico-chemical properties of nanoparticles
Random deposition agregates = “Finding a needle in a haystack” Julien CORDEIRO |
[email protected] David PEYRADE |
[email protected] www.smartforcetechnologies.com
Heterogen material integration
ARC6 1 april 2016 11
Smart Force Unit
Smart Force Kit
Microfluidic cells
Patent n° 14 54166 Product Key Features
Software
nm scale resolution NanoMicrometric Assembly Dynamic visualisation 1 cm2 chip surface 2D and 3D assembly Portable system
Assembly system
Fisrt customer delivery Julien CORDEIRO |
[email protected] David PEYRADE |
[email protected] www.smartforcetechnologies.com
KTH Royal Institut of Technology Stockholm, Sweden ARC6 1 april 2016 12
Products Roadmap 2016
2017
2018
OFFER SMART FORCE
OFFER SMART PRINT
OFFER SMART FORCE PROD.
Equipment: 40k€ Consummable: 1k€ Prestation: 2k€
Equipment: 15k€ Consumable: 1k€
RESEARCH LAB EDUCATION 10 000 worldwide
Equipment: 80k€
INDUSTRIALS 14 000 affiliés nano Telecommunication Energy Health
Julien CORDEIRO |
[email protected] David PEYRADE |
[email protected] www.smartforcetechnologies.com
ARC6 1 april 2016 13
INNOVATIVE MICROBEAD BASED TECHNOLOGY FOR ANTIBODIES IGE DETECTION Microbead based IgE antibody detection by magnetic separation
A. Leonard (PhD)
Microbead PS 10μm Primary Antibody Magnetic microbead 4,5μmSecondary antibody
PS-IgE
Mag-Anti-IgE PS-COOH
Microbead complex
PS-IgE PS-COOH
No filtering 50/50
National research program
LTM Grenoble) Immunolab (Lyon) Smart Force Technologies ©
Magnetic fishing 90/10
AAP 2015 Coord. LTM
Innovative microbead technology for allergy diagnosis
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ASSEMBLY FOR MOLECULAR DIAGNOSIS Microbeads technology
Magnetic fishing
Microbilles
Polystyrene beads (10µm) IgE
Biochip
50 µm 1 mm
Magnetic bead Anti-IgE
Sensitivity , integration, cost
Thermodynamic assembly
Reactive beads collection IgE
Lens-free imaging analysis
FOV 20 mm X 15 mm / Resolution 5 µm
Assemblage (billes + IgE)
Allergens tests – Patient serum ISAC Chip
Food Insects Drugs
Ara h2 Arachid validation
Pollen & … plants Coll. Pharmaciens
Partners LTM –coord (Grenoble) Immunolab hospital (Lyon) AOMC-Pharmacology (Toulouse) CEA INAC (Grenoble) Smart Froce Technologies © (Grenoble)
Test on patient serum (3000 human allergens / cross-allergy)
Synergy of technologies Microbeads solutions for molecular diagnosis Health applications: allergy, oncology…
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Conclusion • A LTM sucessfull story in nanotechnology • Human adventure • Explore an entrepeunarial model (organic – lab sell ) - The spin-off company Smart force technology © is launched • Institutional support (CEA CNRS LTM INAC SATT) • Ride an academic-industrial partnership Transfert new technologies LTM/MNH
Health Applications Synergy
Company students Assembly
2015
David PEYRADE |
[email protected]
Lithography
2016
Imaging
Allergy diagnosis
2018 ARC6 1 april 2016 16
David PEYRADE |
[email protected]
ARC6 1 april 2016 17
From prototype to final product Le prototype
Le produit final
Design du prototype Sous-traitance : Atelier de Chartreuse
+
Cellules microfluidiques Fabrication en interne du prototype David PEYRADE |
[email protected]
Brevet FR14 54166 CEA/CNRS/UJF ARC6 1 april 2016 18