A 21ST CENTURY NEW GENERATION ECOLOGICAL DISINFECTANT

A 21ST CENTURY NEW GENERATION ECOLOGICAL DISINFECTANT 2 | NEXT GENERATION DEEP CLEANSING & INFECTION CONTROL SOLUTIONS Background DISINFECTION, WA...
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A 21ST CENTURY NEW GENERATION ECOLOGICAL DISINFECTANT

2 | NEXT GENERATION DEEP CLEANSING & INFECTION CONTROL SOLUTIONS

Background DISINFECTION, WATER TREATMENT, FOOD HYGIENE, INFECTION-CONTROL AND AGRICULTURAL

EndoSan™ is an ecological disinfectant product that can be used for a multitude of applications across many market sectors. It is a new, exclusive and original generation of ecological disinfectants based on activated and stabilised hydrogen peroxide. This unique composition is safe for people and the environment, providing a real alternative to products based on halogens, chlorine, bromine or iodine and aldehydes, phenols, quaternary ammonium compounds and others. EndoSan™ is equally effective against both gram positive and gram negative bacteria. Active against all types of fungi, viruses, moulds, spores and amoebae, it removes the organic deposits and biofilm in the water, so that the probability of new sources of infection are dramatically reduced, if not extinguished completely.

EndoSan™ is colourless, odourless and miscible with water at all ratios.

It’s high efficiency is due to the in-depth action of special additives which prevent the spontaneous breakdown of the hydrogen peroxide. In the presence of micro-organisms EndoSan™ increases its Biocidal activity by forming high energetic active oxygen. This action guarantees a long-lasting disinfection.

In agriculture, it can be used to disinfect the soil and plants in a safe, economical and environmentally friendly manner.

EndoSan™ is environmentally friendly as the active ingredient is hydrogen peroxide, a chemical compound hybrid of hydrogen and oxygen. During the disinfection it decomposes into water and oxygen therefore no dangerous substances are formed.

It does not cause any change in smell or taste when it comes into contact with water, beverages or food products.

In food hygiene, EndoSan™ is environmentally compatible and stable. It is made from a food grade formulation of hydrogen peroxide. EndoSan™ products are quality disinfectants, offering remarkably effective solutions to the HORECA segment, animal farms, and food-processing factories. In healthcare, EndoSan™ ensures medical hygiene and protection from cross infections of MDR strains, MRSA and Legionella.

“This was found to be an excellent disinfectant and bio film remover with many uses. EndoSan™ will disinfect water, deep clean water tanks and systems, patient area and equipment contact surfaces. This disinfectant is EU approved as a standalone medical device and is approved for use by the NHS, the Ministry of Defence and DEFRA for mass decontamination purposes.” Manni Rehal - Bsc, MCMI, NEBOSH Cert, Pg Dip, VRCT Projects - Equipment New Hospitals Project Team Barts and The London NHS Trust

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Water Treatment SWIMMING POOLS, SPA AND THERAPY POOLS, COOLING TOWERS, LAKES, FOUNTAINS, SEWAGE PLANTS, IRRIGATION WATER, WATER TREATMENT PLANTS AND POTABLE WATER

EndoSan™ ensures an excellent level of hygiene in and around swimming pools, spa and therapy pools, saunas and all types of recreational sanitary facilities without causing smell or slippery floors. Treating the water in swimming pools or whirlpools with EndoSan™ will result in crystal clear water without any irritation for the user. Just some of the benefits that are offered by EndoSan™ an eco-friendly, non-toxic, swimming pool water disinfectant are listed below • Totally chlorine free, eco-friendly swimming pool without odour and taste. No red eyes or skin irritations - after activation, EndoSan™ decays into water and oxygen • More swimming pleasure with oxygen enriched water • Long lasting fresh and microbe-free clear water • Economical due to high stability and reduced maintenance costs • More enjoyable bathing in a non-toxic environment, no carcinogenic or mutagenic effect • Safe and completely disinfected water ensuring no transfer of disease • No biofilm formation - no need to routinely drain and remove swimmers body fats, etc • No algae formation, no side effects and no smells • Prevents recontamination, hence reducing maintenance costs • Highly effective in temperatures ranging from 0°C - 95°C and from pH levels ranging from 2 to 9 Swimming is an enjoyable, healthy activity performed by millions of people worldwide.

It is important that the water maintains a continuous residual disinfectant concentration to counteract the pollutants and pathogenic micro-organisms which are constantly added to the water through general usage.

LEGIONELLA CONTROL Legionella is a ubiquitous, naturally occurring bacterium. Colonies of Legionella can breed in various types of water storage and domestic water systems, such as those found in care homes, hospitals, schools and commercial buildings. The HSE believe legionnaires disease is preventable and it is subject to L8 legislation, applicable to all public buildings within the UK. The effect of this legislation is to place a personal as well as corporate liability on all estate owners, regardless of size and stature. Risk assessments have to be carried out in all cases and be made available for inspection upon request. Failure to provide required documentation will result in prohibition notices and in the event of an outbreak, prosecution.

The bacterial loads in swimming pools, spas and water parks are of major concern for the health and well-being of the patrons who use their facilities. The risk of illness associated with swimming pools and water parks are primarily linked to faecal contamination of the water. An effective water sanitisation regime makes the water safe to swim in, as it will eliminate some pathogens and inhibit the growth of others.

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Non-toxic, safe and easy to use Odourless, colourless, tasteless Safe to foodstuffs & fully biodegradable HACCP compliant biofilm remover No undesirable side-effects Broad-spectrum multipurpose disinfectant Bacterial and virucidal agent Highly effective in Legionella control

‘CONSTANT DOSING’ SYSTEM EndoSan™ AOT (Advanced Oxidative Technology) can be constantly dosed into any water system eliminating the need to heat water to 60°C, the recommended temperature for Legionella control. Following risk assessment in compliance with L8, some water treatment facilities and estate management groups now utilise EndoSan™ AOT and our Constant Dosing system as the preferred method of Legionella control in healthcare and public buildings throughout the UK.

FEATURES Proven, substantial energy saving on water heating Completely sterilises water without the use of harmful chemicals such as chlorine L8 legislation compliant, protecting your responsible person Prevents serious infectious diseases including MRSA, E-Coli, Legionella, C-dif. Eliminates the need to clean showerheads, taps or monitor water temperature throughout buildings.

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EndoSan™ is an ecological, broad spectrum disinfectant and acts as a bactericide, virucide, sporicide, fungicide, algaecide and amoebicide. It is based on next generation advanced German technology, with a unique combination of hydrogen peroxide and activated silver.

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DANGERS OF CHLORINE USAGE IN POOLS AND SPAS: If chlorine can shorten the life of your pool or spa components (regardless of composition), just think of what it’s doing to your body. The typical chlorine level a pool or spa owner maintains is 10 times the recommended level the EPA (Environmental Protection Agency) deems safe. External exposure to chlorine can cause your skin to prematurely age and has been known to cause acne, eczema, melanoma, psoriasis, and seborrhea. Breathing the chemical can damage lung tissue and chemical contact to the eye can cause blindness.

EndoSan™ silver stabilised hydrogen peroxide was used at the 2012 London Olympics replacing chlorine as an additive to disinfect ice baths, therapy and treatment pools located at the athletes training facilities. These measures were taken to alleviate all concerns surrounding the dangers of chlorine and the inhalation of chlorine gas.

CHLORINE VERSUS ENDOSAN™ Chlorine

EndoSan™

Does not remove biofilm

Will remove biofilm and thus clean tanks and pipes

Produces unwanted by-products including carcinogens

Does not form chlorinated by-products

Is corrosive and unpleasant to handle

Is much less corrosive than chlorine. Does not hydrolyse to form an acid

Already banned in certain parts of Europe & the USA

Is rapidly replacing chlorine in many parts of Europe & the USA

Is pH dependent and very ineffective above pH 7

Is not pH dependent

Is ineffective against complex organisms (e.g.: cysts & protozoa)

A very broad spectrum kill*

Neutralisation required before dumping to the foul drain

Because no unwanted by-products are formed, no neutralization normally required

Cannot be used at temperatures above 40ºC due to the release of chlorine gas

Effective at higher temperatures-does not disassociate as rapidly as chlorine

Increased disinfection time and more service work required to combat high bug counts

Cost savings in labour and use efficiency outweighs the additional chemical costs *Efficacy data available on page 7

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Complete Medical Hygiene ROOM DISINFECTION, WATER DISINFECTION, INSTRUMENT DISINFECTION, SURFACE DISINFECTION AND HAND DISINFECTION

MEDICAL WATER TREATMENT

LOW LEVEL DISINFECTION

Biofilm removal

Common areas

The use of EndoSan™ as an additive to hospital water systems ensures an excellent level of hygiene in all day to day applications. EndoSan™ helps to prevent common problems and the spread of different microbes in hospital water (such as legionella).

Disinfecting non-critical medical equipment and devices and non-critical surfaces is very important. EndoSan™ used as a low-level disinfectant will kill most vegetative bacteria and some fungi as well as enveloped viruses.

EndoSan™ also removes organic deposits and biofilms from distribution system taps and pipes to avoid bacterial growth like pseudomonas, aeruginosa, pneumonia and p.aeruginosa. In addition, EndoSan™ is chlorine and alcohol free which is specifically useful for cancer patients since chlorine encourages the growth of tumours as many studies have proved.

DISINFECTING THE ENVIRONMENT Control of MRSA and MDR EndoSan™ is used to create a 99.999% germ free environment in hospitals and clinics. EndoSan™ can be applied by ultrasonic atomisation and will stop the spread of many different airborne micro-organisms and viruses. These micro-organisms directly cause conditions like legionnaires’ disease, bronchitis, asthma and influenza. Ultrasonic atomisation is a leading-edge delivery system which contributes greatly to a successful disinfection and a clean patient environment.

HIGH LEVEL DISINFECTION (HLD) Operation theatre and critical areas EndoSan™ can be used as a high level disinfectant (HLD) to reduce the transmission of pathogens to patients, and to disinfect semi critical medical equipment and critical surfaces. EndoSan™ used as a HLD destroys vegetative bacteria, mycobacteria, fungi and enveloped and nonenvelope viruses.

Examples of non-critical equipment are blood pressure cuffs, stethoscopes, bedpans, urinals, commodes, oximeters, glucose meters, electronic thermometers, hydrotherapy tanks, lift slings, ECG machine leads, IV poles, wheel chairs, call bells, and fingernail equipment that is for single use only.

FLOORS & WALLS For medical premises EndoSan™ provides a high level disinfection to all types of floors and walls within hospitals and healthcare environments. This protects against the transmission of contagious diseases like hospital acquired pneumonia, MRSA, urinary-tract infections and many others.

DENTAL APPLICATION Dental disinfectant with Biofilm removal EndoSan™ used as a dental disinfectant is highly effective in combating the spread of viruses such as Hepatitis B (HBV), Hepatitis C (HCV), Human Immunodeficiency Virus (HIV) and many other viruses and bacteria. In addition, EndoSan™ will remove the biofilm that can form in dental chair tubes where bacteria and viruses can grow easily. EndoSan™ can also be used to disinfect medical instruments such as medical utensils, kidney trays and a wide range of dental equipment and accessories used in dental clinics and hospitals.

Examples of semi-critical equipment are respiratory therapy equipment, trans-rectal probes, nebuliser cups, ear syringe nozzles and CPR face masks.

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Food Hygiene FRUIT AND VEGETABLE DISINFECTION

Bacteria can divide every 20 minutes and one single bacterium can multiply into over 8 million cells in less than 24 hours. EndoSan™ can be used to prevent periodical outbreaks of food-borne illness, which is directly linked to the cross contamination of micro-organisms through a variety of means.

EndoSan™ has good stability, no health hazards to human beings and no technical or disposal concerns. EndoSan™ also meets the stringent environmental, health and safety and HACCP standards for food hygiene.

EndoSan™ can be deployed through atomisation to protect against the flow of air-borne micro-organisms which lead to contamination of food.

EndoSan™ used as a food hygiene disinfectant, is an effective cleaning and sanitisation solution for all food halls, production equipment and food stuffs.

Cross contamination can be controlled with our eco-friendly disinfectant product during the preparation of food, and the cleaning and disinfection of food production areas. EndoSan™ will disinfect floors, walls, surfaces and handles to kill bacteria, fungi, and other micro-organisms. During disinfection, EndoSan™ decomposes into oxygen and water so no harmful substances are left on any food or equipment.

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Agricultural Applications HORTICULTURAL APPLICATIONS AND PLANT DISEASES CONTROL

EndoSan™ is a new, innovative disinfection technology in the agricultural sector, helping to disinfect agriculture and plants in a safe, economical and environmentally friendly manner. A preventative approach is a very important principle in plant disinfection, aiming to eliminate a disease before it can trigger the economic damage threshold (EDT) value. EndoSan™ is made to be highly ecological as well as being a cost-effective plant disinfectant against many harmful fungi and bacteria. EndoSan™ is an outstanding and environmentally friendly plant activator and disinfectant. It is made from a special grade of stabilised hydrogen peroxide (disinfectant) as a biocide with a residual balance of demineralised water. EndoSan™ is used against root fungal disease, powdery and denaby mildew, peronospora on grapes and other bacteria like pseudomonas and erwinia.

SOIL DISINFECTION EndoSan™ eliminates soil-borne disease especially pythuim and fusarium as well as contributing to resolving the nematoda problem. EndoSan™ increases the oxilation of organic matter present in the soil, by enhancing their decompensation. They are then transformed into simpler forms that can be more easily accepted by plant life. Moreover it stimulates the root growth and helps in controlling the harmful pathogens.

• Minimises the pesticide residuals and micro load on the fruits and vegetables. • Enhances the salt tolerance of plants by increasing their photosynthesis activities. • Thickens the leaves’ outer layer so they become more resistant to suckers like accarose. • Kills the eggs and larva of insects. EndoSan™ used in agriculture will: • Remove the biofilm present in irrigation water, preventing the growth of algae and slime. • Disinfect the irrigation water removing all harmful bacteria, viruses, fungi and spores. • Increase oxygenation at root zone. • Increase water quality in hydroponics raising the level of dissolved oxygen in nutrient and fertilizer solutions, thereby stimulating growth. • Protect and extend the shelf life of fresh fruits and vegetables, and decontaminate the ready-to-eat crop.

Advantages of EndoSan™: • Encourages the plant to produce natural components to fight against harmful fungi and bacteria. • Provides resistance to the plant when under stress during flowering and fruiting stage where it is more sensitive to pathogens. • Increases the quality and yield of crops and decreases the frequency of spraying.

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Huwa-San™ Efficacy IS BASED ON HUWA-SAN TECHNOLOGIES

EndoSan (Silver Catalysed hydrogen Peroxide) against test micro organisms detailed below

ORGANISM

STRAIN

CONCENTRATION TEST HOUSE/ METHOD /STANDARD

Enterococcus faecium

ATCC 8043

0.5-1%

LOVAP NF T 72-190

Enterococcus faecium

ATCC 8043

1%

LOVAP NF T 72-150

Enterococcus hirae

ATCC 1054

1.5%

Universiteit Antwerpen EN 13727

Enterococcus hirae

ATCC 10541

7%

Universiteit Antwerpen EN 1276

Escherichia coli

ATCC 25922

0.1%

LOVAP NF T 72-150

Escherichia coli

ATCC 25922

0.15%

LOVAP NF T 72-190

Escherichia coli

ATCC 11229

0.5%

Institut Fresenius DGHM 1981

Escherichia coli

ATCC 10536

0.5%

Universiteit Antwerpen EN 13727

Escherichia coli

ATCC 10536

3%

Universiteit Antwerpen EN 1276

Klebsiella pneumoniae

ATCC 4352

0.5%

Institut Fresenius DGHM 1981

Lactobacillus brevis

Laboratory

0.1%

Technical University München In-house

Legionella pneumophilagroup 1

ATCC 33152

0.2%

TNO Nutrition &Food Research prEN 13623

Legionella pneumophilagroup 1

Environmental

0.4%

Université de Nancy NF T 72-150

Legionella pneumophilagroup 3

Environmental

0.4%

Université de Nancy NF T 72-150

Mycobacterium avium

ATCC 15769

5%

Universiteit Antwerpen EN 14348

Mycobacterium smegmatis

ATCC 15755

1%

LOVAP NF T 72-190

Mycobacterium terrae (surrogate

NCTC 10856

2.5%

NHS test laboratory M. tuberculosis

Mycobacterium terrae

NCTC 10856

7.5%

Universiteit Antwerpen EN 14348

Mycobacterium tuberculosis

ATCC 25618

0.5%

Institut Fresenius DGHM 2.1

Pediococcus damnosus

Laboratory

0.1%

Technical University München In-house

Proteus mirabilis

NCTC 10975

0.1%

LOVAP NF T 72-150

Proteus mirabilis

ATCC 14153

1%

Institut Fresenius DGHM 1981

Pseudomonas aeruginosa

ATCC 27853

0.1%

LOVAP NF T 72-150

Pseudomonas aeruginosa

ATCC 27853

0.2%

LOVAP NF T 72-190

Pseudomonas aeruginosa

ATCC 15442

0.5%

Universiteit Antwerpen EN 13727

Pseudomonas aeruginosa

ATCC 15442

1%

Institut Fresenius DGHM 1981

Pseudomonas aeruginosa

ATCC 15442

3%

Universiteit Antwerpen EN 1276

Staphylococcus aureus

ATCC 25923

0.1%

LOVAP NT T 72-150

Staphylococcus aureus

ATCC 25923

0.15%

LOVAP NF T 72-190

Staphylococcus aureus

ATCC 6538

0.5%

Institut Fresenius DGHM 2.1

Staphylococcus aureus

ATCC 6538

2%

Universiteit Antwerpen EN 13727

BACTERIA: NON-SPORE-FORMING

Staphylococcus aureus

ATCC 6538

3%

Universiteit Antwerpen EN 1276

Streptococcus faecalis

ATCC 6057

0.25%

Institut Fresenius DGHM 1981

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ORGANISM

STRAIN

CONCENTRATION TEST HOUSE/ METHOD /STANDARD

BACTERIA: SPORE-FORMING Bacillus cereus

ATCC 9139

0.5-1%

LOVAP NF T 72-190

Bacillus cereus

NCTC 7464

1%

LOVAP NF T 72-150

Bacillus subtilis

ATCC 6633

0.2-1%

LOVAP NF T 72-190

Bacillus subtilis

NCTC 10073

2.5%

Hospital Infection Laboratory (NHS)

Clostridium sporogenes

ATCC 3584

0.5%

Institut Fresenius DGHM 1981

Clostridium sporogenes

ATCC 11437

1%

LOVAP NF T 72-190

YEASTS/MOULDS/FUNGI Absidia corymbifera

ATCC 38957

0.2-1%

LOVAP NF T 72-190

Aspergillus niger

ATCC 16404

2%

Universiteit Antwerpen EN 13624

Aspergillus niger

ATCC 16404

5%

Universiteit Antwerpen EN 1650

Candida albicans

ATCC 38906

0.2%

LOVAP NF T 72-190

Candida albicans

ATCC 10231

1%

Institut Fresenius DGHM 1981

Candida albicans

ATCC 10231

1.5%

Universiteit Antwerpen EN 13624

Candida albicans

ATCC 10231

2%

Universiteit Antwerpen EN 1650

Cladosporium cladosporioides

ATCC 38906

0.2%

LOVAP NF T 72-190

Penicillium notatum

ATCC 9179

1%

LOVAP NF T 72-150

Penicillium verrucosum

ATCC 38905

0.5 - 1%

LOVAP NF T 72-190

Saccharomyces cerevisiae

Laboratory

0.1%

Technical University München In-house

Saccharomyces cerevisiae

ATCC 9763

1%

Universiteit Antwerpen EN 13624

Saccharomyces cerevisiae

ATCC 9763

2%

Universiteit Antwerpen EN 1650

VIRUSES: ENCAPSULATED Newcastle disease virus

Montana

0.5%

Inst for Applied Animal Hygiene DVG 1988

Vaccinia virus

Elstree

0.5%

Inst for Applied Animal Hygiene DVG 1988

1%

Universiteit Antwerpen EN 14476

VIRUSES: NON-ENCAPSULATED Adenovirus Type 5 Echovirus

LCR 4

0.5%

Inst for Applied AnimalHygiene DVG 1988

Feline calicivirus

(surrogate 62804 (primary)

0.5%

Glasgow Caledonian University In-house for human Norovirus EPA SOP

Poliovirus Type 1

1%

Universiteit AntwerpenEN 14476

Reovirus Type 1

0.5%

Institute for Applied Animal Hygiene DVG 1988

PROTOZOA: AMOEBAE & AMOEBIC CYSTS Acanthamoeba culbertsoni

Laboratory

1%

Jeune Equipe Universitaire, Rennes

Acanthamoeba MR4

Laboratory

1%

Jeune Equipe Universitaire, Rennes

Hartmanella vermiformis

Laboratory

1%

Jeune Equipe Universitaire, Rennes

Naegleria fowleri 0359

1%

Jeune Equipe Universitaire, Rennes

Naegleria gruberi1518

1%

Jeune Equipe Universitaire, Rennes

Naegleria gruberi Paris

1%

Jeune Equipe Universitaire, Rennes

Naegleria gruberi M05

1%

Jeune Equipe Universitaire, Rennes

1%

Jeune Equipe Universitaire,Rennes

SPOROZOA Cryptosporidium parvumoocysts

Laboratory

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Huwa-San™ Global Approvals IS BASED ON HUWA-SAN TECHNOLOGIES

EUROPE

EGYPT

BE06/1286.CE.01 - Disinfectants for medical devices Notified body number 1639

24291/2005 - Disinfection in pharmaceutical industryMinistry of health

CE Marked specifically for use in the NHS

COAE-Dis.-5/09 - Organic agriculture - Centre of Organic Agriculture in Egypt

NATO 6505-13-119-7486 - Nato Stock Number SWITZERLAND CHZN0433 - Disinfection in medical sector, swimming pools, agriculture, and food industry - Ministry of Health care

ENGLAND - UK DWI 56.4.573 - Disinfection of waterworks apparatus and distribution systems 2163-3/94 - PT 4 - Food industry - Ministry of Health

CHZNO433 - Drinking water disinfection CHZN0432 - Disinfection in medical sector, swimming pools, agriculture, and food industry - Ministry of Health CHZNO433 - Drinking water disinfection AUSTRALIA IOA No 7723 - No rinse sanitizer - Disinfection in food industry - Export control BELGIUM 397 B - PT 3 and 4 - Veterinary and food industry - Ministry of Health

INDIA Disinfectant for sanitation and hygiene of food contact surfaces - Central Institute of Fisheries Technology THE NETHERLANDS 12677 N - PT 2 - Public health care - surface disinfection and disinfection through vaporisation - CTB 12766 N - PT 4 - Cosmetic and Food industry -CTB

3300 B - PT 2 and 4 - Public health care, private use and food industry - Ministry of Health

12766 N - PT 4 - Disinfection of installations that come into contact with drinking water - CTB

Liquid cat. 3 for drinking water installation - Belgaqua

K23515/01 - Oxidizing cleaner in drinking water sector - KIWA

DENMARK

K 23516/01 - Oxidizing cleaner in drinking water sector - KIWA

2004-20-5409-00215 - PT 3 and 4 - Food industry and cattle breeding - Ministry of food industry

POLAND

GERMANY

HK/W/0502/01/2009 - surfaces of swimming pools, saunas, Jacuzzis - PZH

VAH/DGHM- PT 2 - Public health care

HK/W/0502/02/2009 - PZH

DLG - group 3 - cleaning and disinfection in the milk industry

HK/W/0502/03/2009 - disinfection of airco systems - PZH

PT 2, PT 3, PT 4 - BAUA number - Federal institute for occupational safety and health

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SCOTLAND Disinfection of waterworks apparatus and distribution systems SPAIN General disinfection - Ministry of Health Disinfection in food industry - Ministry of Health Disinfection in veterinary industry - Ministry of Health Legionella disinfection - Ministry of Health UNITED ARAB EMIRATES 812/02/02/1/29481 - Food industry, disinfection of food equipment, pipes and other food contact surfaces Ministry of Health Care 812/02/02/1/901928 - Food industry - Food control department Dubai Drinking water - Al Wasmi pure drinking water Food industry - Abu Dhabi food control authorities Laboratory disinfectant - Government of Ajman

EndoSan™ has approvals across many countries worldwide for use as a general disinfectant, a high level disinfectant (HLD), a medical device and an industry specific disinfectant. EndoSan™ | 15

CONTACT US Head Office. Endo Enterprises (UK) Ltd. Unit 231, Europa Boulevard, Gemini Business Park, Warrington, Cheshire, WA5 7TN United Kingdom

T. + E. [email protected] W. www.endoenterprises.com

NEXT GENERATION DEEP CLEANSING & INFECTION CONTROL SOLUTIONS