332 88:04 Vitamin A | 88:08 Vitamin B
88:00 VITAMINS 88:04 VITAMIN A VITAMIN A Indication: Vitamin A deficiency. Pregnancy Risk Factor: A ( Risk factor X if used in dose above the U.S.RDA.) Breast Feeding Recommendation: Compatible Usual Dose: 3-4 cap daily. Adverse Reaction: Irritability, vertigo, lethargy, malaise, fever, headache, Drying and crackingnof skin, Hypervitaminosis A, Weight loss, Visual changes. Contraindication: N/A Drug Interaction: Aminoglycosides, kanamycin, mineral oil, neomycin, paromomycin. Storage: < 25°C, protect from light. Preparations: Capsule (Softgel) 25,000 iu VITAMIN A ATLANTIC EDก; Atlantic
88:08 VITAMIN B MECOBALAMIN (VITAMIN B12) Indication: Peripheral neuropathies. Pregnancy Risk Factor: A [Risk factor C if used in dose above the RDA.] Breast Feeding Recommendation: Compatible Usual Dose: Peripheral neuropathies Oral 1 tab tid. Adverse Reaction: Anorexia, nausea/vomiting, diarrhea. Contraindication: Patients with a history of hypersensitivity to mecobalamin. Drug Interaction: No any specific drug interaction has been reported. Storage: Tablets should be stored at room temperature not
exceeding 30°C and should be protected from moisture and light. (Light decomposes the active ingredient and decreases its content. Tablets may turn reddish with humidity.) Preparations: Tablet 500 mcg MECOBA 500 EDก; Sriprasit METHYCOBAL EDก; Eisai/DKSH NEUROMET SUGAR-COATED EDก; Merck/DKSH FOLIC ACID (Pteroylmonoglutamic acid; Vitamin B9) Indication: Megaloblastic anemia due to folic acid deficiency (as may be seen in tropical or non-tropical sprue) and in anemias of nutritional origin, pregnancy, infancy or childhood. Pregnancy Risk Factor: A* compatible [Risk factor C if used in dose above the RDA.] Breast Feeding Recommendation: Compatible Usual Dose: 1-4 tab daily. Adverse Reaction: GI disturbances, hypersensitivity reactions; bronchospasm. Contraindication: Undiagnosed megaloblastic anaemia; pernicious, aplastic or normocytic anaemias. Drug Interaction: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations. Storage: Store at 15-30°C. Preparations: Tablet 5 mg FOLIVIT EDก; Siam NIACIN (NICOTINIC ACID, VITAMIN B3) Indication: Nicotinic acid deficiency, hyperlipidaemia, vaso-
ED คือ ยาในบัญชียาหลักแหงชาติ NR คือ ยานอกบัญชียาหลักแหงชาติที่คณะกรรมการแพทยรับรอง, NS คือ ยานอกบัญชียาหลักแหงชาติ NX คือ ยานอกบัญชียาหลักแหงชาติสำ�หรับผูปวยพิเศษ, HAD (High Alert Drugs) คือ ยากลุมเสี่ยงสูง
333 Vitamin B 88:08 dilation. Pregnancy Risk Factor: A [Risk factor C if used in dose above the RDA or Cm for dose typically used for lipid disorders] Breast Feeding Recommendation: Compatible Usual Dose: Pellagra : oral 50-100 mg. 3 times/day Maximum 500 mg/day Adverse Reaction: Vomiting, diarrhoea, peptic ulceration, jaundice, abnormal LFTs, decreased glucose-tolerance, hyperuricaemia, gout, toxic amblyopia, flushing, pruritus, hyperpigmentation, dry skin and headache, atrial fibrillation, orthostasis, cystoid macular oedema. Contraindication: Liver disease; active peptic ulcer; severe hypotension; arterial bleeding. Drug Interaction: Potentiates the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. Storage: < 30°C, protect from light Preparations: Tablet 50 mg NICOTINIC ACID EDก; ST Pharma PYRIDOXINE (VITAMIN B6) Indication: Treatment and prevention of vit B6 deficiency, sideroblastic anaemia. Pregnancy Risk Factor: A Breast Feeding Recommendation: Compatible Usual Dose: Treatment and prevention of vitamin B6 deficiency up to 150 mg/day. Sideroblastic anemia: up to 400 mg/ day. Vitamin B6 deficiency: (deficiency due to isoniazid) 30 mg/day oral maintenance dose. Polyneuropathy, Peripheral; Treatment and Prophylaxis: (prophylaxis) 25 to 50 mg orally daily. Adverse Reaction: Severe peripheral neuropathies (with long-term admin of large doses). Contraindication: Hypersensitivity to pyridoxine products. Drug Interaction: Isoniazid, penicillamine and oral contraceptives may result in greater requirement in pyridoxine dose. Reduces the effects of levodopa, phenobarbitone, altretamine and phenytoin.
Storage: < 30°C, protect from light. Preparations: Tablet 10 mg VITAMIN B6 NR; March THIAMINE (VITAMIN B1) Indication: Treatment and prevention of mild chronic thiamine deficiency, Wernicke-Korsakoff syndrome, Thiamine deficiency. Pregnancy Risk Factor: A Breast Feeding Recommendation: Compatible Usual Dose: Adult: PO: Treatment and prevention of mild chronic thiamine deficiency 10-25 mg/day in single or divided doses. Thiamine deficiency ≤300 mg/day. IV/IM: WernickeKorsakoff syndrome Initial: 100 mg by slow IV, then 50-100 mg/day IM/IV till patient can take oral thiamine. Adverse Reaction: IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. IM: Tenderness and induration. Potentially Fatal: Very rarely, fatal anaphylactic shock. Contraindication: Hypersensitivity to thiamine products. Drug Interaction: May enhance the effect of neuromuscular blocking agents. Storage: Oral: Store between 15-30°C. Parenteral: Store between 15-30°C. Preparations: Injection 100 mg/1 mL VITAMIN B1 EDก; Golden Cup/Sookprasert Tablet 100 mg VITAMIN B1 EDก; Golden Cup/Sookprasert VITAMIN B1 + VITAMIN B6 + VITAMIN B12
ED คือ ยาในบัญชียาหลักแหงชาติ NR คือ ยานอกบัญชียาหลักแหงชาติที่คณะกรรมการแพทยรับรอง, NS คือ ยานอกบัญชียาหลักแหงชาติ NX คือ ยานอกบัญชียาหลักแหงชาติสำ�หรับผูปวยพิเศษ, HAD (High Alert Drugs) คือ ยากลุมเสี่ยงสูง
334 88:12 Vitamin C | 88:16 Vitamin D Indication: Toxic and nontoxic neuritis, diabetic and alcoholic neuropathy, neurological disease. Pregnancy Risk Factor: Vitamin B1: A, Vitamin B6: A, Vitamin B12: A Breast Feeding Recommendation: Vitamin B1: Compatible, Vitamin B6: Compatible, Vitamin B12: Compatible. Usual Dose: Tablet: 1-2 tab bid-tid. Injection: 1 amp IM, 1-2 times weekly. Drug Interaction: Vit B6 may reduce the effect of levodopa. Storage: < 25°C, store in a dry and cool place. Preparations: Injection Vit B1 100 mg, vit B6 50 mg, vit B12 1 mg TRIVIT-B NR; T.P.Drug; 3 mL Tablet Vit B1 100 mg, vit B6 200 mg, vit B12 200 mcg DOUZABOX NR; Sriprasit Vit B1 100 mg, vit B6 10 mg, vit B12 200 mcg NEUROBION NS; Merck/DKSH VITABION NS; Unison/Medline VITAMIN B COMPLEX Indication: Prevention and treatment of vitamin B deficiency. Pregnancy Risk Factor: A Breast Feeding Recommendation: No human data. Usual Dose: Oral: 1-2 tabs t.i.d. Injection: As directed. Storage: Injection: < 30°C, Tablet: < 25°C Preparations: Injection Vit B1 mononitrate 100 mg, vit B2 1.5 mg, vit B6 5 mg, nicotinamide 50 mg, D-Panthenol 3 mg VITAMIN B COMPLEX EDข; March; 1 mL Tablet NR (Film-coated) Vit B1 mononitrate 5 mg, vit B2 2 mg, vit B6 2 mg, nicotinamide 20 mg VITAMIN B COMPLEX GPO EDก; G.P.O.
88:12 VITAMIN C ASCORBIC ACID (VITAMIN C) Indication: Vit C deficiency; scurvy, hemorrhagic diathesis. Prevention and treatment of capillary bleeding. Adjuvant in the treatment of rheumatism. Nutritional supplement. Pregnancy Risk Factor: A [Risk factor C if used in dose above the RDA.] Breast Feeding Recommendation: Compatible Usual Dose: Tab 1 tab daily. Amp 1-2 amp daily by IV, IM injection. Adverse Reaction: Dermatologic: injection site reaction, Paiin and swelling. Gastrointestinal: Diarrhea . Largedose Hematologic : Iron overload, Large dose. Renal: Nephrolithiasis, Large dose. Contraindication:Hypersensitivity to any component of the preparation. Drug Interaction: Amygdalin, anticoagulants, beta-blockers, contraceptives, oral, estrogens, ethinyl estradiol, fluphenazine, indinavir, phenothiazines, propranolol, protease inhibitors, warfarin. Storage: < 30°C Preparations: Injection 500 mg/2 mL VITAMIN C ATLANTIC EDข; Atlantic Tablet 500 mg VITAMIN C NR; Silom/Diethelm
88:16 VITAMIN D ALFACALCIDOL (1 - α - hydroxyvitamin D3) Indication: Diseases caused by disturbances in the Ca metabolism in consequence of reduced endogenous production of 1,25-dihydroxyvit D3. Osteoporosis. Renal osteodystrophy,
ED คือ ยาในบัญชียาหลักแหงชาติ NR คือ ยานอกบัญชียาหลักแหงชาติที่คณะกรรมการแพทยรับรอง, NS คือ ยานอกบัญชียาหลักแหงชาติ NX คือ ยานอกบัญชียาหลักแหงชาติสำ�หรับผูปวยพิเศษ, HAD (High Alert Drugs) คือ ยากลุมเสี่ยงสูง
335 Vitamin D 88:16 post-op or idiopathic hypoparathyroidism, pseudohypoparathyroidism, as an adjunct to the management of tertiary hyperparathyroidism, vit D-resistant rickets or osteomalacia, vit D-dependent rickets, neonatal hypocalcaemia or rickets, malabsorption of Ca, malabsorptive and nutritional rickets and osteomalacia. Pregnancy Risk Factor: C Breast Feeding Recommendation: Thomson Lactation Rating : Infant risk cannot berule out. Usual Dose: Adult and children >20 kg body weight Initial dose: 1 mcg daily. Children 11 yr 1 vial/day by slow IV inj or infusion. Adverse Reaction: Folic acid may obscure pernicious anemia. Contraindication: Preexisting hypervitaminosis, Intolerance to thiamine. Drug Interaction: Phenytoin, levodopa. Storage:
