MSc Oncology Including PG Certificate and PG Diploma
Part A, Basic Sciences
Module Guide 2015/16: Cell and Molecular Biology of Cancer
Contents
1.
Module Details
3
2.
Joint Module Leaders and Course Administration
4
3.
Lecturers
5
4.
Aims & Learning Outcomes
7
5.
Indicative Syllabus Content
8
6.
Timetable
10
7.
Assessment
15
8.
Learning Resources
16
Cell and Molecular Biology of Cancer - Module Guide 201516
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1
Module details
Full Title:
Cell and Molecular Biology of Cancer
Part of Course:
Part A: Basic Sciences
Compulsory or optional:
Compulsory
ICR Reference Number:
MS1008
Academic Level:
Level 7 (Masters)
Credit Value:
20 Credits
Cell and Molecular Biology of Cancer - Module Guide 201516
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2
Joint module leaders and course administration Name
Post
Affiliation
Dr Zoe Walters
[email protected] 020 8722 4138
ICR Fellow, Sarcoma Molecular Pathology
The Institute of Cancer Research
Dr Timothy Yap
[email protected] 020 8611 3539
NIHR BRC Clinician Scientist and Consultant Medical Oncologist
The Institute of Cancer Research & Royal Marsden
Dr Nicola Valeri
[email protected] 020 8915 6634
Team Leader, Gastrointestinal Cancer Biology and Genomics and Consultant Medical Oncologist
The Institute of Cancer Research & Royal Marsden
Dr Michael Bright
[email protected] 020 8611 4745
Senior Postdoctoral Training Fellow, Cancer Therapeutics Signal Transduction and Molecular Pharmacology
Anna Pili
[email protected] Direct tel: 020 7153 5386 Mobile: 0771 137 5957
MSc Course Manager
MSc Office, Registry The Institute of Cancer Research
Leila Darwish & Hema Mistry
[email protected] 020 7153 5228 / 5384 (Mon-Wed) 020 7965 5949 (Thu-Fri, CCT-Barbican - term time only)
MSc Administrative Team
MSc Office, Registry The Institute of Cancer Research
The Institute of Cancer Research
Cell and Molecular Biology of Cancer - Module Guide 201516
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3
Lecturers
Name
Post
Affiliation
Dr Michael Bright
Senior Postdoctoral Training Fellow Cancer Therapeutics Signal Transduction and Molecular Pharmacology
The Institute of Cancer Research
Dr Paul Clarke
Senior Scientific Officer Signal Transduction and Molecular Pharmacology
The Institute of Cancer Research
Dr James Flanagan
Non-Clinical Senior Lecturer, Division of Cancer Epigenetics Unit
Imperial College London
Dr Angela George
Consultant, Genetic Susceptibility Team
The Royal Marsden
Dr Marco Gerlinger
Team Leader, Translational Oncogenomics
The Institute of Cancer Research
Dr Duncan Gilbert
Consultant Clinical Oncologist
Brighton & Sussex University Hospitals
Dr Mark Harrison
Consultant Clinical Oncologist
Mount Vernon Cancer Centre
Dr James Larkin
Consultant Medical Oncologist
The Royal Marsden
Dr David Miles
Consultant Medical Oncologist
Mount Vernon Hospital
Dr Amit Patel
Clinical Lecturer, Molecular Haematology
The Institute of Cancer Research
Dr George Poulogiannis
Team Leader, Signalling & Cancer Metabolism
The Institute of Cancer Research
Dr Andy Reynolds
Team Leader Tumour Biology
Cell and Molecular Biology of Cancer - Module Guide 201516
The Institute of Cancer Research
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Dr Simon Robinson
Team Leader, Magnetic Resonance
The Institute of Cancer Research
Dr Andrea Sottorivo
Team Leader, Evolutionary Genomics & Modelling
The Institute of Cancer Research
Dr Nicola Valeri
Team Leader, Gastrointestinal Cancer Biology and Genomics and Consultant Medical Oncologist
The Institute of Cancer Research & The Royal Marsden NHS Trust
Dr Timothy Yap
NIHR BRC Clinician Scientist and Consultant Medical Oncologist
Dr Zoe Walters
ICR Fellow
The Institute of Cancer Research & Royal Marsden The Institute of Cancer Research
Note: Students should forward any administrative matters (e.g. timetabling, arrangements for assessment) concerning the module to the MSc Course Office, at
[email protected]. Any academic matters should be forwarded to the Module Leaders or Joint Course Directors as appropriate.
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Assessment Guide 2015/16
4
Aims and learning outcomes Aims The module aims to guide you to acquire and develop an awareness and appreciation of the molecular and cellular processes underlying the development of cancer; and synthesise the lectures and knowledge into clinical practice.
Learning objectives To develop a critical awareness and appreciation of the cellular and molecular features of malignancy with a critical awareness of recent developments and current research directions. To develop a critical awareness of the common laboratory techniques used in order for the student to be able to evaluate and critically analyse research findings. To develop a core of knowledge to enable the student to critically evaluate and analyse current and future research in cancer biology and its translation to cancer medicine. To develop a basic knowledge of the importance of host-tumour interactions. To appreciate the implications of new paradigms in tumour dissemination such as cancer stem cells, non-coding RNA and epigenetic modulation of gene expression, cancer metabolism, tumour heterogeneity and clonal evolution. To understand the basics of molecularly targeted cancer therapy and the importance of predictive and prognostic biomarkers.
Cell and Molecular Biology of Cancer - Module Guide 201516
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5
Indicative syllabus content The module is based upon the key ‘Hallmarks of Cancer’ expounded by Hanahan and Weinberg General Principles of Tumour Biology • •
DNA, RNA and proteins and their importance in studying cancer biology The cell cycle and basic cell kinetics, including parameters associated with cell cycle
The genetics of normal and malignant cells • • • • • • • • •
Normal chromosomal structure/function, gene transcription, DNA repair mechanisms Gene polymorphisms, mini and microsatellites Genome instability, gene amplification and deletion
Epigenetics, chromatin structure and function Methylation, hypomethylation and methylation reversal Chromosomal and genetic changes in malignancy Oncogenes, proto-oncogenes, tumour suppressor genes (including discussion of well -established examples in each class) Protein-protein interactions Normal and aberrant mechanisms of cell growth control
Normal and aberrant mechanisms of cell growth control • • • •
Control of normal cell growth and behaviour# Altered expression, function and control of these mechanisms in malignancy The role of mitotic kinases Gene promoters and their activity in normal and malignant cells
Techniques in Molecular Biology •
Nucleic acid analyses including electrophoresis, hybridisation, blotting, PCR, sequencing, transfection • Micro array techniques Protein and phosphoprotein assays (western blot, ELISA)
Cell and Molecular Biology of Cancer - Module Guide 201516
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Causation of Human Cancers •
Carcinogenesis, causative factors and interaction with DNA repair
Cancer Genetics • •
Inherited syndromes associated with cancer Genes conferring susceptibility to cancer and mechanisms whereby such genes can be associated with neoplasia
Cancer Progression • • • • • •
Multistep oncogenesis. Cancer initiation and evolution Mechanisms involved in oncogenesis focussing on events at the cellular level including loss of differentiation, neoangiogenesis, adhesion Hypoxia: biology, role in cancer progression and treatment resistance Invasion, cell motility, metastasis, host/tumour interactions, patterns of metastasis Cancer and host immune response. Using gene therapy and immunotherapy to treat cancer Biomarkers of response to therapy: using circulating cells and DNA, biopsies, surrogate tissues, body fluids, non-invasive imaging
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Assessment Guide 2015/16
6
Timetable
(NB. This timetable is subject to change; please see Canvas for updated timetables and weekly announcements) 9th October – 18th December 2015 Session Date
Start Time
Lecture Title
09/10/2015
09:15
Registration
09/10/2015
09:30
Ice Breaker Quiz
09/10/2015
10:30
BREAK
09/10/2015
10:45
The Nature of Cancer
Dr Mark Harrison
09/10/2015
11:45
The Nature of Cancer
Dr Mark Harrison
09/10/2015
12:45
LUNCH
09/10/2015
13:45
Hallmarks of Cancer
Dr Mark Harrison
09/10/2015
14:45
Hallmarks of Cancer
Dr Mark Harrison
09/10/2015
15:45
BREAK
09/10/2015
16:00
How to write an essay
16/10/2015
09:15
Registration
Lecturer1
Lecturer2
Dr Mark Harrison
Prof Robert Huddart
Cell and Molecular Biology of Cancer - Module Guide 201516
Ms Anna Pili
Page 10 of 21
16/10/2015
09:30
DNA, RNA, Protein
16/10/2015
10:30
BREAK
16/10/2015
10:45
DNA, RNA, Protein
Dr Zoe Walters
16/10/2015
11:45
DNA, RNA, Protein
Dr Zoe Walters
16/10/2015
12:45
LUNCH
16/10/2015
13:45
16/10/2015
14:45
16/10/2015
15:45
BREAK
16/10/2015
16:00
Germline Instability
23/10/2015
09:15
Registration
23/10/2015
09:30
Genome Instability
23/10/2015
10:30
BREAK
23/10/2015
10:45
Genome Instability
Dr Amit Patel
23/10/2015
11:45
Genome Instability
Dr Amit Patel
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Novel strategies to target DNA repair in the clinic Novel strategies to target DNA repair in the clinic
Dr Zoe Walters
Dr Tim Yap
Dr Tim Yap
Dr Angela George
Dr Amit Patel
Assessment Guide 2015/16
23/10/2015
12:45
23/10/2015
13:45
23/10/2015
14:45
23/10/2015
15:45
23/10/2015
16:00
30/10/2015
09:15
Registration
30/10/2015
09:30
Anti-Angiogenic
30/10/2015
10:30
BREAK
30/10/2015
10:45
Anti-Angiogenic
Dr David Miles
30/10/2015
11:45
Anti-Angiogenic
Dr David Miles
30/10/2015
12:45
LUNCH
30/10/2015
13:45
Signalling
Dr Michael Bright
30/10/2015
14:45
Signalling
Dr Michael Bright
30/10/2015
15:45
BREAK
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LUNCH Oncogene & Tumour Suppressors Oncogene & Tumour Suppressors
Dr Igor Vivanco Dr Igor Vivanco
BREAK
Dr David Miles
Assessment Guide 2015/16
Dr Michael Bright
30/10/2015
16:00
Signalling
06/11/2015
09:15
Registration
06/11/2015
09:30
Angiogenesis
06/11/2015
10:30
BREAK
06/11/2015
10:45
Angiogenesis
Dr Andy Reynolds
06/11/2015
11:45
Angiogenesis
Dr Andy Reynolds
06/11/2015
12:45
LUNCH
06/11/2015
13:45
Immunology
Dr Sergio Quezada
06/11/2015
14:45
Immunology
Dr Sergio Quezada
06/11/2015
15:45
BREAK
06/11/2015
16:00
Immunotherapy
13/11/2015
09:15
Registration
13/11/2015
09:30
Liquid Biopsies in cancer
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Dr Andy Reynolds
Dr James Larkin
Dr Nicola Valeri
Assessment Guide 2015/16
13/11/2015
10:30
BREAK
13/11/2015
10:45
microRNAs
Dr Nicola Valeri
13/11/2015
11:45
microRNAs
Dr Nicola Valeri
13/11/2015
12:45
LUNCH
13/11/2015
13:45
PD Biomarkers
Dr Tim Yap
13/11/2015
14:45
PD Biomarkers
Dr Tim Yap
13/11/2015
15:45
BREAK
13/11/2015
16:00
Imaging
20/11/2015
Dr Simon Robinson
READING WEEK
27/11/2015
09:15
Registration
27/11/2015
09:30
Clonal Evolution
27/11/2015
11:00
BREAK
27/11/2015
11:15
Pathology of heterogeneity
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Dr Andrea Sottoriva
Dr Nicola Valeri
Assessment Guide 2015/16
27/11/2015
12:15
LUNCH
27/11/2015
13:15
Intertumoural Heterogeneity
Dr Marco Gerlinger
27/11/2015
14:15
Intertumoural Heterogeneity
Dr Marco Gerlinger
27/11/2015
15:15
BREAK
27/11/2015
15:30
Intertumoural Heterogeneity
04/12/2015
09:15
Registration
04/12/2015
09:30
Metabolism
04/12/2015
10:30
BREAK
04/12/2015
10:45
Metabolism
Dr George Poulogiannis
04/12/2015
11:45
Metabolism
Dr George Poulogiannis
04/12/2015
12:45
LUNCH
04/12/2015
13:45
Metastasis
Dr Michael Bright
04/12/2015
15:15
Immortality
Dr Duncan Gilbert
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Dr Marco Gerlinger
Dr George Poulogiannis
Assessment Guide 2015/16
11/12/2015
09:15
Registration
11/12/2015
09:30
Evading Apoptosis
11/12/2015
10:30
BREAK
11/12/2015
10:45
Evading Apoptosis
Dr Paul Clarke
11/12/2015
11:45
Evading Apoptosis
Dr Paul Clarke
11/12/2015
12:45
LUNCH
11/12/2015
13:45
Epigenetics
Dr James Flanagan
11/12/2015
14:45
Epigenetics
Dr James Flanagan
11/12/2015
15:45
BREAK
11/12/2015
16:00
Epigenetics
18/12/2015
09:15
Registration
18/12/2015
09:30
Lab Visits
18/12/2015
11:00
BREAK
18/12/2015
11:15
Revision
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Dr Paul Clarke
Dr James Flanagan
Ms Anna Pili
Dr Zoe Walters
Dr Michael Bright
Assessment Guide 2015/16
18/12/2015
12:45
LUNCH
18/12/2015
14:45
Revision
Dr Zoe Walters
Dr Michael Bright
18/12/2015
14:45
Essay Writing
Dr Zoe Walters
Dr Michael Bright
18/12/2015
15:45
BREAK
18/12/2015
16:00
Essay Writing
Dr Zoe Walters
Dr Michael Bright
22/07/2016
TBC
Course Revision Day
All lectures will be held at: CCT Venues-Barbican Aldersgate House 135-137 Aldersgate Street London EC1A 4JA
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Assessment Guide 2015/16
7
Assessment
The following assessment methods will be used in this module. Please refer to the Assessment Guide for more guidance.
Essay The Module Leaders will allocate each student an essay title. The essay will be 1500 words. The essay will be used to allow examination of the depth of the student’s understanding of a specific aspect of Cell & Molecular Biology along with their ability to critically appraise data and to demonstrate its relationship and relevance to a clinical environment. Essays should relate to the basic sciences you have been learning during the year. Please take care to recognise that we will assess you in relation to the science of the specific module. Be sure to include relevant references to journal papers where appropriate. In addition all students will sit a single best answer paper (The paper will be of 45 minutes duration. This assessment needs to be passed but will not contribute to the overall module mark.
Cell and Molecular Biology of Cancer - Module Guide 201516
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8
Learning resources
The following learning resources are relevant to this module: Main Key Papers You are strongly advised to read the key papers for this module. •
Hallmarks of Cancer: The Next Generation, Hanahan and Weinberg, Cell Vol 4 Issue 5, pp. 646-674 (2011)
•
Cancer and Its Management, Souhami and Tobias, 6th Edition, 2007 (John Wiley And Sons Ltd)
•
Practical Clinical Oncology, Hanna, Crosby and Macbeth (eds), 2008 (Cambridge)
Additional Key Papers Students are encouraged to read these papers •
Intrinsic Tumour Suppression; Lowe, Cepera and Evan, Nature 432, 307-315 (2004)
•
Cancer genes and the pathways they control; Vogelstein and Kinzler, Nature Medicine 10, 789-799 (2004)
•
Chemotherapy and the war on cancer; Chabner and Roberts, Nature Reviews Cancer 5, 65-72 (2005)
•
Cancer immunotherapy – revisited, W. Joost Lesterhuis, John B. A. G. Haanen & Cornelis J. A. Punt, Nature Reviews Drug Discovery 10, 591-600 (August 2011)
•
Past, present and future of molecular and cellular oncology, Galluzzi Lorenzo ,Vitale Ilio,Kroemer Guido, Frontiers in Oncology, 2011
•
The grand challenges to cellular and molecular oncology, Lorenzo Galluzzi and Guido Kroemer, Frontiers in Oncology, 2011
•
Cell death signaling and anticancer therapy, Lorenzo Galluzzi, Ilio Vitale, Erika Vacchelli and Guido Kroemer, Frontiers in Oncology, 2011
Cell and Molecular Biology of Cancer - Module Guide 201516
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Core Texts •
The Biology of Cancer, RA Weinberg, 2nd edition, 2013 (Garland Science)
•
Cancer Biology, Raymond W Ruddon, 4th edition, 2007 (Oxford University Press)
•
The Molecular Biology of Cancer: A Bridge from Bench to Bedside, Ed S Pelengaris and M Khan, 2nd edition, 2013 (WileyBlackwell)
•
Cancer Biology. King and Robins, 3rd edition, 2006 (Prentice Hall)
•
The Basic Science of Oncology, Tannock, Hill et al., 5th edition, 2013 (McGraw-Hill Medical)
•
Introduction to the Cellular and Molecular Biology of Cancer, Knowles and Selby (eds.), 4th edition, 2005 (Oxford University Press)
Other reading •
Cancer Medicine Review, Kufe, Pollock, Weischbaum, Bast, Gansler, Holland and Frei, 6th edition 2003 (BC Decker)
•
The Genetic Basis of Human Cancer, Vogelstein and Kinzler, 2nd edition, 2002 (McGraw-Hill Education)
•
Molecular Biology of the Cell, Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter, 6th edition, 2014 (Garland Science)
•
Molecular Cell Biology, Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Amon and Scott, 7th edition, 2012 (WH Freeman, Palgrave Macmillan)
•
Oxford Textbook of Oncology, Souhami, Tannock, Hohenberger and Horiot, 2nd edition 2001 (Oxford University Press)
•
Lewin’s Genes XI, Krebs, Goldstein and Kilpatrick, 11th edition, 2014 (Jones & Bartlett)
•
Genetic Predisposition to Cancer, Eeles, Easton, Ponder and Eng (eds.), 2nd edition, 2004 (CRC Press)
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Assessment Guide 2015/16
Dr Zoe Walters
Dr Nicola Valeri
Dr Timothy Yap
Dr Michael Bright
Cell and Molecular Biology of Cancer Module Leaders
MSc Oncology The Institute of Cancer Research
First Edition: September 2006 for Academic Year 2006-2007 Second Edition: July 2007 for Academic Year 2007-2008 Revised: November 2007 Revised October 2008 for Academic Year 2008-9 Revised January 2010 for Academic Year 2009-10 Revised July 2010 for Academic Year 2010-11 Updated November 2010 for Academic Year 2010-11 Revised September 2011 for Academic Year 2011-12 Revised June 2012 for Academic Year 2012-13 Updated October 2012 for Academic Year 2013-14 Updated September 2013 for Academic Year 2013-14 Update August 2014 for Academic Year 2014-15 Update September 2014 for Academic Year 2014-15 Revised November 2014 for Academic Year 2014-15 Updated September 2015 for Academic Year 2015-16
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Assessment Guide 2015/16
