Patrick Kyongmin Ha DEMOGRAPHIC AND PERSONAL INFORMATION Current Appointments Johns Hopkins Hospital, Baltimore, MD, 7/06 – present Associate Professor Department of Otolaryngology Head and Neck Surgery Johns Hopkins Head and Neck Surgery at the Greater Baltimore Medical Center, Baltimore, MD, 1/06 – present Attending Surgeon Personal Data Johns Hopkins Contact Information: 1550 Orleans Street, Rm 5M06 David H Koch Cancer Research Building II Baltimore, MD 21231 Phone: 410-502-8210 Fax: 410-614-1411 Greater Baltimore Medical Center Contact Information: Physicians Pavilion West, Suite 401 6569 North Charles Street Baltimore, MD 21204 Phone: 443-849-8940 Fax: 443-849-8965 Education and Training Year 1991-95 1995-99 1999-00 2000-05 2006

Degree Bachelor of Arts Medical Doctor Internship Residency Advanced Training

Institution Harvard College Johns Hopkins SOM Johns Hopkins Hospital Johns Hopkins Hospital Johns Hopkins Hospital

Discipline Biology Medicine General Surgery Otolaryngology Head & Neck Surgery

PROFESSIONAL EXPERIENCE Dates 1/1/2006 – 6/30/06 7/1/2006 – 9/2011 10/11 – present 1/1/2006 – present

Position Instructor Assistant Professor Associate Professor Attending Surgeon

Institution Johns Hopkins Department of Otolaryngology Johns Hopkins Department of Otolaryngology Johns Hopkins Department of Otolaryngology Greater Baltimore Medical Center

RESEARCH ACTIVITIES Peer Reviewed Original Research Articles

1. Hruban RH, Petersen GM, Ha PK, Kern SE. Genetics of pancreatic cancer: from genes to families. Surgical Oncology Clinics of North America. 1998 Jan;7(1):1-23. PMID: 9443984 2. Ha PK, Eisele DW, McCarthy EW, Frassica FJ, Zahurak ML. Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope. 1999 Jun;109(6):964-9. PMID: 10369291 3. Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real time quantitative PCR demonstrates low prevalence of human papillomavirus Type 16 in Premalignant and Malignant Lesions of the Oral Cavity. Clinical Cancer Research. 2002 May; 8(5): 1203-9. PMID: 12006539 4. Capone RB, Ha PK, Westra WH, Pilkington TM, Sciubba JJ, Koch WM, Cummings CW. Oncocytic neoplasms of the parotid gland - a sixteen year institutional review. Otolaryngology – Head and Neck Surgery, 2002 June; 126(6): 657-62. PMID: 12087334 5. Ha PK, Tong BC, Westra WH, Sanchez-Cespedes M, Parrella P, Zahurak M, Sidransky D, Califano JA. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Clinical Cancer Research, 2002 Jul; 8(7): 2260-5. PMID: 12114429 6. Ha PK, Pilkington TA, Westra WH, Sidransky D, Califano JA. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. International Journal of Cancer. 2002 Dec 20;102(6):615-7. PMID: 12448003 7. Tong BC, Ha PK, Dhir K, Xing M, Westra WH, Sidransky D, Califano JA. Mitochondrial DNA alterations in thyroid cancer. J Surg Oncol. 2003 Mar;82(3):170-3. PMID: 12619060 8. Ha PK, Benoit NE, Westra WH, Sciubba JJ, Califano JA. A transcriptional progression model for head and neck cancer using expression microarrays. Clin Cancer Res. 2003 Aug 1;9(8):3058-64. PMID: 12912957 9. Goldenberg D, Harden S, Masayesva B, Ha P, Benoit N, Westra W, Koch W, Sidransky D, and Califano J. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg, 2004 Jan;130(1):39-44. PMID: 14732766 10. Tong BC, Dhir K, Ha PK, Westra WH, Alter BP, Sidransky D, Koch WM, Califano JA. Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity. Head Neck. 2004 Apr;26(4):345-52. PMID: 15054738 11. Masayesva BG, Ha P, Garrett-Mayer E, Pilkington T, Mao R, Pevsner J, Speed T, Benoit N, Moon CS, Sidransky D, Westra WH, Califano J. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc Natl Acad Sci USA. 2004 Jun 8;101(23):8715-20. PMCID:423261 PMID: 15155901 12. Sirianni N, Ha PK, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP, DeLeo A, Ferris RL. Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004 Oct 15;10(20):6929-37. PMID: 15501971

13. Kim MM, Clinger JD, Masayesva BG, Ha PK, Zahurak ML, Westra WH, Califano JA. Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res. 2004 Dec 15;10(24):8512-5. PMID: 15623632 14. Ha PK, Couch ME, Tufano RP, Koch WM, Califano, JA. Short Hospital Stay After Neck Dissection. Otolaryngol Head Neck Surg. 2005 Nov;133(5):677-80. PMID: 16274791 15. Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, Califano J, Cummings CW, Flint PW, Wahl R, Tufano RP. The Role of Positron Emission Tomography / Computed Tomography Fusion in the Management of Early and Advanced Stage Primary Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Jan;132(1):12-6. PMID: 16415423 16. Zhao M, Begum S, Ha PK, Westra W, Califano J. Downregulation of RAD17 in head and neck cancer. Head Neck, 2007 Jul;30(1): 35-42. PMID: 17657792 17. Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha PK, Koch W, Califano J. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncology, 2008 Oct;44(10):915-9. PMCID:3215237 18. Durr ML, Saunders JR, Califano JA, Tufano RP, Koch WM, Ha PK. Severe hypocalcemia complicating thyroid surgery after roux-en-y after gastric bypass operation. Archives of Otolaryngology Head and Neck Surgery, 2009 May;135(5);507-10. 19. Lyford-Pike S, Ha PK, Jacene HA, Saunders JR, and Tufano RP. PET/CT Evaluation of residual neck disease after primary chemoradiation. ORL J Otorhinolaryngol Relat Spec. 2009;71(5):251-256. Epub Sept 16. PMID 19776658 20. Hillel AT, Fakhry C, Williams MF, Blanco RG, Zinreich ES, Levine MA, Saunders JR, and Ha PK. Selective versus comprehensive neck dissection after primary chemoradiation therapy for advanced head and neck cancer. Otolaryngology Head and Neck Surgery, 2009. Dec;141(6):737-42. PMID 19932847 21. Mithani SK, Shao C, Tan M, Smith IM, Califano JA, El-Naggar AK, and Ha PK. Mitochondrial mutations in adenoid cystic carcinomas of the salivary glands. PLoS One, 2009;4(12);e8493. PMCID:2795173 22. Bai W, Shao C, Ha PK, and Califano JA. Conservative management of transnasal intracranial injury. Am J Otolaryngol, 2011 Mar-Apr;32(2):165-7. Epub 2010 Jan 8. PMID 20060199 23. Durr ML, Agrawal N, Saunders JR, Ha PK. Laryngeal lipoma associated with diffuse lipomatosis: Case report and literature review. Ear Nose Throat J. 2010 Jan;89(1):34-7. PMID: 20155698 24. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, and Califano JA. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis via increased aerobic glycolysis and HIF1a stabilization. Clin Cancer Res. 2010: Feb1;16(3):857-66. PMCID:2824550

25. Durr ML, Mydlarz WK, Shao C, Zahurak M, Chuang AY, Hoque MO, Westra WH, Liegeois NJ, Califano JA, Sidransky D, and Ha PK. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010 May 26;5(5):e10828. PMCID:2877085 26. Dasgupta S, Koch R, Westra WH, Califano JA, Ha PK, Sidransky D, and Koch WM. Mitochondrial DNA mutation in margins and tumors of recurrent HNSCC patients. Cancer Prev Res. 2010 Sep;3(9):1205-11. Epub 2010 Jul 26. PMCID:3040952 27. Bai W, Zhou X, Gao X, Shao C, Califano JA, Ha PK. The value of chest CT in the diagnosis and management of tracheobronchial foreign bodies. Pediatr Int. 2011 Aug;53(4):515-8. Epub 2010 2010 Dec. PMID 21129123 28. Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, and Messing BP. Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck: 2011 Dec;33(12):1727-34. Epub 2011 Jan 18. PMID: 21246640 29. Blanco RG, Ha PK, Califano JA, Saunders JM. Transoral robotic surgery of the vocal cord. J Laparoendosc Adv Surg Tech A. 2011 Mar;21(2);157-9. Epub 2011 Feb 16. PMID: 21323600 30. Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, Sidransky D, Califano JA, and Ha PK. Evaluation of Myb promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol. 2011 Apr;47(4):251-5. Epub 2011 Feb 15. PMCID:3065551 31. Shao C, Sun W, Tan M, Glazer CA, Bhan S, Zhong X, Fakhry C, Sharma R, Westra WH, Hoque MO, Moskaluk CA, Sidransky D, Califano JA, and Ha PK. Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clinical Cancer Research. 2011 Jul 1;17(13):4320-30. Epub 2011 May 6. PMCID:3131484 32. Bhan S, Negi SS, Shao C, Glazer CA, Chuang A, Gaykalova DA, Sun W, Sidransky D, Ha PK, Califano JA. BORIS binding to the promoters of cancer testis antigens, MAGE A2, MAGE A3 and MAGEA4, is associated with their transcriptional activation in lung cancer. Clinical Cancer Research. 2011 Jul 1;17(13):4267-76. Epub 2011 May 10. PMCID:3172963 33. Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D, Kim MS. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol, 2011, Aug;39(2):337-44. Epub May 23. PMCID:3601031 34. Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha PK. Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma. Ann Surg Oncol. 2012 Jun;19(6):1980-7. PMID: 22290566 35. Zaboli D, Tan M, Gogineni H, Lake S, Fan K, Zahurak M, Messing B, Ulmer K, Zinreich ES, Levine MA, Tang M, Pai SI, Blanco RG, Saunders JR, Best SR, Califano J, and Ha PK. Hyperfractionated radiotherapy with concurrent cisplatin5-fluorouracil for locoregional advanced head and neck cancer: Analysis of 105 consecutive patients. Int J Otolaryngology. 2012 Jun 21.754191 [Epub]. PMCID: 3388433

36. Gaykalova D, Vatapalli R, Glazer, CA, Bhan S, Shao C, Sidransky D, Ha PK, Califano JA. Dose-dependent activation of putative oncogene SBSN by BORIS. PLoS One, 2012;7(7):e40389. Epub 2012 Jul 5. PMCID:3390376 37. Junn JC, Sciubba JJ, Bishop JA, Zinreich E, Tang M, Levine MA, Palermo RA, Fakhry C, Blanco RG, Saunders JR, Califano JA, and Ha PK. The effect of amifostine on submandibular gland histology after radiation. Int J Otolaryngology, Epub 2012 Jul 15 2012:508279. PMCID:3403191 38. Curry M, Malpani A, Li R, Tantillo T, Jog A, Blanco R, Ha PK, Califano J, Kumar R, Richmon J. Objective assessment in residency-based training for transoral robotic surgery. Laryngoscope. 2012 Oct;122(10):2184-92. Epub 2012 Aug 22. PMID: 22915265 39. Melvin TA, Eliades SJ, Ha PK, Fakhry C, Saunders JM, Califano JA, and Blanco RG. Neck dissection through a facelift incision. Laryngoscope, 2012 Dec;122(12):2700-6. PMID: 23023877 40. Blanco RG, Ha PK, Califano JA, Fakry C, Richmon J, Saunders JM. Robotic-assisted neck dissection through a pre- and post-auricular hairline incision: preclinical study. J Laparoendosc Adv Surg Tech A, 2012 Oct;22(8);791-6. PMID: 23039702 41. Shao C, Tan M, Bishop JA, Liu J, Bai W, Gaykalova DA, Ogawa T, Vikani AR, Agrawal Y, Li RJ, Kim MS, Westra WH, Sidransky D, Califano JA, Ha PK. Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma. PLoS One, 2012;7(11):e48582. Epub 2012 Nov 12. PMCID: 3492451 42. Junn JC, Kim IA, Zahurak ML, Tan M, Fan KY, Lake ST, Zaboli D, Messing BP, Ulmer K, Harrer KB, Gold D, Ryniak KL, Zinreich ES, Tang M, Levine MA, Blanco RG, Saunders JR, Califano JA, Ha PK. Multidisciplinary service utilization pattern by advanced head and neck cancer patients: a single institution study. Int J Otolaryngology, 2012. Epub 2012 Oct 18. PMCID: 3483826 43. Sen T, Sen N, Noordhuis MG, Ravi R, Wu TC, Ha PK, Sidransky D, Hoque MO. OGDHL is a Modifier of AKT-Dependent Signaling and NF- κB Function. PLoS One, 2012;7(11): e48770. Epub 2012 Nov 12. PMCID: 3495966 44. Kumar R, Curry M, Ha PK, Blanco R, Califano J, Richmon J. In response to Objective assessment in residency-based training for transoral robotic surgery. Laryngoscope, 2013 May;123(5): 1317. 2013 Feb 12. PMID 23404291 45. Brait M, Munari E, LeBron C, Noordhuis MG, Begum S, Michalidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D, Hoque MO. Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. Cell Cycle. 2013 Feb 22;12(7). Epub 2013 Feb 22. PMID: 23435205 46. Tan M, Fakhry C, Fan K, Zaboli D, Neuner G, Zinreich ES, Levine, MA, Tang M, Blanco RG, Saunders JR, Califano JA, Ha PK. Timing of restaging PET/CT and neck dissection after chemoradiation for advanced head and neck squamous cell carcinoma. Otolaryngology, 2013 Feb 15; 3:128. 47. Blanco RG, Fakhry C, Ha P, Ryniak K, Messing B, Kim M, Shellenberger J, Valasek L, Hieber B, Califano JA, Saunders JM. Transoral robotic surgery (TORS) experience in 44

cases. J of Laparascopic & Advanced Surgical Techniques, 2013 Nov;23(11); 900-7. PMID: 24083851. 48. Mydlarz WK, Uemura M, Ahn S, Hennessey PT, Chang S, Demokan S, Sun W, Shao c, Bishop JA, Krostin J, Mambo E, Westra WH, Ha PK, Sidransky D, Califano JA. Clusterin is a gene specific target of microRNA-21 in head and neck squamous cell carcinoma. Clinical Cancer Research. 2014 Feb 15;20(4);868-77. PMID: 24327270 48. Tan M, Shao C, Bishop JA, Feng Z, Trock BJ, Westra WH, Ha PK. Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngology Head Neck Surgery. 2014, May;150(5):801-7. PMID: 24493792. 49. Blanco R, Califano J, Messing B, Richmon J, Liu J, Neuner G, Quon H, Saunders J, Ha P, Sheth S, Gillison M, Fakhry C. Transcervical ultrasound is feasible to visualize and evaluate base of tongue cancers. PLos One. 2014 Jan 30;9(1);e87565. PMID: 24498138. 50. Chen Z, Chen J, Gu Y, Hu C, Li JL, Lin S, Shen H, Cao C, Gao R, Li J, Ha PK, Kaye FJ, Griffin JD, Wu L. Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells. Oncogene. 2013 Aug 26. [Epub ahead of print]. PMID: 23975434. 51. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncology. 2014 Jun;50(6)600-4. PMID: 24630260. 52. Bishop JA, Yonescu R, Batista D, Yemelyanova A, Ha PK, Westra WH. Mucoepidermoid carcinoma does not harbor transcriptionally active high risk human papillomavirus even in the absence of the MAML2 translocation. Head Neck Pathol, 2014 Sep;8(3);298-302. PMID: 24706055. 53. Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand C, Seethala RR, Sano D, Myers JN, Ha PK, Grandis JR, Gaither LA, Puthenveedu MA, Duvvuri U. To “grow” or “go”: TMEM16A expression as a switch between tumor growth and metastasis in SCCHN. Clinical Cancer Research. Sep 1;20(17);4673-88. PMID: 24919570. 54. Benson EM, Hirata RM, Thompson CB, Ha PK, Fakhry C, Saunders JR, Califano JA, Arnaoutakis D, Levine M, Tang M, Neuner G, Messing BP, Blanco RG. Pharyngocutaneous fistula after total laryngectomy: a single-institution experience, 2001-2012. Am J Otolaryngol: 2014 Sep2, [Epub ahead of print]. PMID 25245411. 55. Califano JA, Khan Z, Noonan K, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin C, Ha P, Saunders J, Levine M, Tang M, Neuner G, Richmon J, Blanco R, Agrawal N, Koch W, Marur S, Weerd D, Serafini P, Borrello I. Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Accepted for publication, Clinical Cancer Research, August 2014. 56. Sobel RH, Tan M, Shao C, Bishop JA, Fertig EJ, Considine M, Yonescu R, Feng Z, Trock BJ, Ha PK. Wilms’ tumor 1 promoter is hypermethylated and associated with metastasis in salivary adenoid cystic carcinoma. Submitted for publication.

Peer Reviewed Review Articles 1. Ha PK, Califano JA. The molecular biology of laryngeal cancer. Otolaryngology Clinics of North America. 2002 Oct;35(5):993-1012. PMID: 12587244 2. Ha PK, Califano JA. The molecular biology of mucosal field cancerization of the head and neck. Crit Rev Oral Biol Med. 2003;14(5):363-9. PMID: 14530304 3. Ha PK, Califano JA. The role of human papillomavirus in oral carcinogenesis. Crit Rev Oral Biol Med, 2004 Jul 01;15(4):188-96. PMID: 15284184 4. Ha PK and Califano JA. Promoter methylation and tumor suppressor gene inactivation in oral squamous cell carcinoma. Lancet Oncol. 2006, Jan;7(1):77-82. PMID 16389187 5. Ha PK. The molecular/genetic basis of oral cancer. Grand Rounds in Oral Systemic Medicine. 2007, Feb 2(1): 20-28. 6. Agrawal N and Ha PK. The Management of early-stage laryngeal carcinoma. Otolaryngology Clinics of North America. 2008 Aug;41(4):757-69. PMID: 18570957 7. Glazer CA, Chang SS, Ha PK, and Califano JA. Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncology. 2009 AprMay;45(4-5);440-6. Epub 2008 Jul 31. PMID 18674958 8. Ha PK, Chang SS, Glazer CA, Califano JA, and Sidransky D. Molecular techniques and genetic alterations in head and neck cancer. Oral Oncology, 2009 Apr-May;45(4-5):335-9. Epub 2008 Jul 31. PMCID:2702241

9. Liu J, Shao C, Tan ML, Mu D, Ferris RL, and Ha PK. The molecular biology of adenoid cystic carcinoma. Head and Neck, 2012 Nov;34(11):1665-77. PMCID:3262103 Extramural Sponsorship Current: Status: Project Number (PI): Source: Title: Dates of Project: Annual direct costs/effort: Annual total costs: Role: Status: Project Number (PI): Source: Title: Dates of Project: Annual direct costs/effort: Annual total costs:

Active 1 HHSN26820090039C 01 (Ha, Westra) National Institute of Dental and Craniofacial\ Research – DHHS - NIH Salivary gland tumor biorepository 8/10/09 – 8/9/15 Annual $23,000/0.6 cal/months $30,000 Co-Principal investigator of subaward Active n/a Champions Biotechnology Acquisition and sharing of head and neck tumor xenografts 1/1/10 – 12/31/16 Annual $/0.12 cal/months $60,000

Role:

Principal Investigator

Status: Project Number (PI): Source:

Active R01DE023227-01 (Ha) NIH, National Institute of Dental and Craniofacial Research Integrated pathway analysis of altered driver genes in adenoid cystic carcinoma 9/1/12 – 8/31/16 Annual $250,000/3.0 cal/months $405,000 Principal investigator

Title: Dates of Project: Annual direct costs/effort: Annual total costs: Role: Pending: Status: Project Number (PI): Source: Title: Dates of Project: Annual direct costs/effort: Annual Total direct costs Role:

Active NIH 5T32DC000027 (Fuchs, P.A.) National Institute of Deafness and Communication Disorders Research training in otolaryngology-HNS 7/1/09 – 6/30/14 Annual $250,000/0.6 cal/months Co-Director

Previous: Status: Project Number (PI): Source: Title: Dates of Project: Annual direct costs/effort: Annual total costs: Role: Status: Project Number (PI): Source: Title: Dates of Project: Role: Active/Pending: Source: Title: Dates of Project:

Completed 1R03DE022591-01 (Ha) National Institute of Dental and Craniofacial Research Array-based screening for the expression and regulation of tumor suppressor genes 7/1/12 – 6/30/14 Annual $100,000/2.4 cal/months $82,000 Principal investigator Completed NIH 5T32DC000027-18 (Cummings, Charles) National Institutes of Health T32 training grant National Institute of Deafness and Communication Disorders Research training in otolaryngology 7/1/00 – 6/30/02 Trainee Completed Johns Hopkins Clinician Scientist Award (Ha, Patrick) The role of promoter hypermethylation in adenoid cystic carcinoma 1/1/07 – 12/31/08

Annual direct costs: Role:

$60,000 for year one, $40,000 for year two Principal Investigator

Active/Pending: Source/PI:

Completed Adenoid Cystic Carcinoma Research Foundation (Ha, Patrick) Deriving Adenoid Cystic Carcinoma Cell Lines from Xenograft explants 7/15/08 – 7/14/09 $23,200 $25,520 Principal Investigator

Title: Dates of project: Annual direct costs: Total costs: Role: Active/Pending: Project Number (PI): Source: Title: Dates of Project: Annual direct costs: Role: Active/Pending: Project Number (PI): Source: Title: Dates of project: Annual direct costs/effort: Annual total costs: Role:

Status: Project Number (PI): Source: Title: Dates of Project: Annual direct costs/effort: Annual total costs: Role:

Research Presentations/Abstracts

Completed NIH 9P50DE019032-06 (Sidransky, David) National Institutes of Health SPORE Award National Institute of Dental and Craniofacial Research SPORE in Head and Neck Cancer, Pilot Project Award 9/1/07 – 9/30/09 Annual $30,000 Principal Investigator of pilot project award Completed NIH 1K08DE018463 (Ha, Patrick) National Institutes of Health K08 Award National Institute of Dental and Craniofacial Research The role of promoter hypermethylation in adenoid cystic carcinoma 7/1/07 – 12/31/12 Annual $124,750 / 9 cal/months $134,730 Principal Investigator

Completed RDCRC – U54, OD-08-001 (Ha, Patrick) NIH U54 Collaborative Grant National Institute of Dental and Craniofacial Research Biomarker discovery and validation of salivary gland carcinomas by integrative multiplatform profiling 7/1/09 – 6/30/13 Annual $45,732/1.2 cal/months $75,000 Principal Investigator of methylation component of this collaborative grant

1. Toward a definition of familial pancreas cancer. Petersen GM, Ha PK, Falatko F, Kern SE, Hruban RH. Oral Presentation. Fifth SPORE Investigators Workshop, Rockville, MD, July, 1997. 2. Mitochondrial DNA Mutations in Premalignant Lesions of the Head and Neck. Oral Presentation. Greater Baltimore Medical Center Resident Research Forum. Baltimore, Maryland, March 2001. 3. Mitochondrial DNA Mutations in Premalignant Lesions of the Head and Neck. Oral Presentation. The Johns Hopkins Medical and Surgical Association Biennial Meeting. Baltimore, Maryland, June 2001. 4. Oncocytic neoplasms of the parotid gland - a sixteen year institutional review. Oral Presentation. Capone RB, Ha PK, Westra WH, Pilkington TM, Sciubba JJ, Koch WM, Cummings CW. American Academy of Otolaryngology Head and Neck Surgery, Denver, CO, September 2001. 5. Progression of microsatellite instability in premalignant lesions of the head and neck. Oral Presentation. Ha PK, Pilkington TA, Westra WH, Sidransky D, Califano JA. American Head and Neck Society Meeting, Boca Raton, Florida, May 2002. 6. Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. Oral Poster Presentation. Ha PK, Tong BC, Westra WH, Sanchez-Cespedes M, Parrella P, Zahurak M, Sidransky D, Califano JA. 93rd American Association for Cancer Research, San Francisco, CA, April 2002. 7. A transcriptional progression model for head and neck cancer using expression microarrays. Oral Presentation. Ha PK, Benoit NE, Westra WH, Sciubba JJ, Califano JA. The Sixth Research Workshop on the Biology, Treatment and Prevention of Head and Neck Cancer, McClean, Virginia, October 2002. 8. Molecular Screening in a population at risk for head and neck cancer: preliminary results. Oral Poster Presentation. Jiang WW, Taylor R, Koch W, Sidransky D, Ha P, Minhas K, Benoit N, Califano J. The Sixth Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancer, McLean, Virginia, October 2002. 9. Intraoperative molecular margin analysis in head and neck cancer. Goldenberg D, Harden S, Masayesva B, Ha P, Benoit N, Westra W, Koch W, Sidransky D, and Califano J. Oral Presentation. American Head and Neck Society, Nashville, Tennessee, September 2003. 10. The Role of Positron Emission Tomography / Computed Tomography Fusion in the Management of Early and Advanced Stage Primary Head and Neck Squamous Cell Carcinoma. Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, Califano J, Cummings CW, Flint PW, Wahl R, Tufano RP. Oral Presentation. American Head and Neck Society, Boca Raton, Florida, May 2005. 11. Alteration of Methylation Profiles for Multiple Tumor Suppressor Gene Promoters in Salivary Gland Tumors. Mydlarz WM, Hoque MO, Westra WH, Califano JA, Ha PK. Oral Poster Presentation. American Head and Neck Society, Chicago, Illinois, August 2006. 12. Positron Emission Tomography-Computed Tomography in Patients with Advanced Head and Neck Cancer After Primary Chemoradiotherapy; Evaluation of its Efficacy in Identifying Residual Disease. Lyford-Pike S, Ha PK, Jacene H, Wahl R, Saunders JR, Tufano RP. Oral Poster Presentation. American Head and Neck Society, San Diego, California, April 2007.

13. Mitochondrial mutation is a frequent event in salivary adenoid cystic cancers. Mithani SM, Califano J, Ha PK. Oral Presentation, Second International Congress on Salivary Gland Diseases, Pittsburgh, Pennsylvania, October 19, 2007. 14. Selective versus comprehensive neck dissection after primary chemoradiation therapy for advanced head and neck cancer. Hillel AT, Fakhry C, Williams MF, Blanco RG, Zinreich ES, Levine MA, Saunders JR, and Ha PK. Oral Presentation. 7th International Conference on Head and Neck Cancer, San Francisco, California, July 19-23, 2008. 15. High-throughput integrative epigenetic genome-wide screen for proto-oncogenes in salivary adenoid cystic carcinoma. Shao C, Tan M, Glazer C,Sun W, Chang X, Demokan S, Sidransky D, Califano J, Moskaluk C, and Ha P. Poster presentation, American Academy of Cancer Research 100th annual meeting, Denver, CO, April 19,2009. 16. Integrated, genome-wide discovery approach identifies oncogene candidate in salivary adenoid cystic carcinoma. Shao C and Ha PK. Poster presentation, National Institute of Dental and Craniofacial Research Training Day, Bethesda, MD, March 3, 2010. 17. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis via increased aerobic glycolysis and HIF1 alpha stabilization. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, and Califano JA. Poster presentation, American Academy of Cancer Research 101st annual meeting, Washington DC., April 2010. 18. BORIS binding to the promoters of cancer testes antigens, MageA2 and MageA3 causes transcriptional activation of these genes in lung cancer. Bhan S, Negi SS, Glazer CA, Chuang A, Sun W, Gaykalova D, Shao C, Ha PK, and Califano JA. Poster presentation, American Academy of Cancer Research 101st annual meeting, Washington DC., April 2010. 19. Integrated screening of epigenetically controlled tumor suppressor genes and oncogenes in salivary adenoid cystic carcinoma. Shao C, Sun W, Cope L, Bai W, Zhong X, Sidransky D, Califano J, Moskaluk C, and Ha PK. Poster presentation, American Academy of Cancer Research 101st annual meeting, Washington DC., April 2010. 20. Duration of mucositis is associated with pharyngeoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, and Messing BP. Poster presentation, American Head and Neck Society 2010 Annual meeting, Las Vegas, NV, April 28-29, 2010. 21. MYB promoter methylation in salivary adenoid cystic carcinoma. Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, Sidransky D, Califano JA, Moskaluk C, Ha PK. Poster presentation, American Head and Neck Society 2010 Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancers. Arlington, VA., October 28-30, 2010. 22. Comparison of Two Primary Chemoradiation Regimens in the Treatment of Advanced Head and Neck Squamous Cell Carcinoma. Fan K, Gogineni H, Zaboli D, Lake S, Zahurak M, Levine M, Tang M, Zinreich E, Saunders JR, Califano JA, Blanco R, Pai SI, Messing B, Ha PK. Poster presentation, American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 27-28, 2011.

23. Effects of amifostine on submandibular gland histology in patients undergoing chemoradiation therapy for stage IV head and neck squamous cell carcinoma. Junn JC, Sciubba JJ, Bishop JA, Zinreich E, Palermo RA, Tang M, Levine MA, Blanco RG, Saunders JR, Califano JA, Ha PK. Poster presentation, American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 27-28, 2011. 24. Screening for Oncogene and Tumor Suppressor Gene Candidates by DNA Methylation Array in Salivary Gland Adenoid Cystic Carcinoma. Shao C, Uemura M, Bhan S, Chang X, Moskaluk C, Sidransky D, Califano J, Ha P. Poster presentation, American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 27-28, 2011. 25. Suprabasin (SBSN) Hypomethylation is a Hallmark of Many Salivary Gland Tumors. Shao C, Liu J, Bai W, Gaykalova D, Bhan S, Chang X, Sidransky D, Califano J, Ha P. Poster presentation, American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 2728, 2011. 26. Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) is Overexpressed and Hypomethylated in Salivary Gland Adenoid Cystic Carcinoma. Shao C, Tan M, Glazer C, Bhan S, Chang X, Uemura M, Moskaluk C, Sidransky D, Califano J, Ha P. Poster presentation, American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 27-28, 2011. 27. BORIS and MageA expression correlate positively in melanoma. Bhan S, Shao C, Wang H, Glazer C, Lobanenkov V, Ha P, Califano J. Poster presentation, American Academy of Cancer Research 2011 Annual Meeting, April 2-6, Orlando, FL. 28. MicroRNAs in head and neck squamous cell carcinoma. Uemura M, Mydlarz W, Chang S, Hennessey P, Sun W, Shao C, Ha P, Sidransky D, Califano J. Poster presentation, American Academy of Cancer Research 2011 Annual Meeting, April 2-6, Orlando, FL. 29. Cancer-specific transcription factor BORIS has different effects on expression of its target genes via chromatin structure alterations. Gaykalova DA, Glazer CA, Vatapalli R, Bhan S, Shao C, Ha PK, Califano JA. Poster presentation, American Academy of Cancer Research 2011 Annual Meeting, April 2-6, Orlando, FL. 30. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Chang X, Cho Y, Park I, Yamashita K, Shao C, Ha P, Pai S, Sidransky D, and Kim M. Poster presentation, American Academy of Cancer Research 2011 Annual Meeting, April 2-6, Orlando, FL. 31. DNA methylation array screening in salivary gland adenoid cystic carcinoma. Shao C, Tan M, Bishop JA, Vikani A, and Ha PK. Poster presentation, American Academy of Cancer Research 2012 Annual Meeting, March 31 – April 4, Chicago, IL. 32. Aquaporin-1 promoter hypomethylation is associated with local recurrence in salivary gland adenoid cystic carcinoma. Tan M, Shao C, Bishop JA, Vikani A, Westra WH, Ha PK. Poster presentation to American Head and Neck Society 8th International Conference on Head and Neck Cancer, July 21-25, 2012, Toronto, ON, Canada. 33. RASSF1a Promoter Hypermethylation in Adenoid Cystic Carcinoma. Bishop JA, Tan M, Shao C, Vikani AR, Westra WH, and Ha PK. Oral presentation to American Head and Neck Society 8th International Conference on Head and Neck Cancer, July 21-25, 2012, Toronto, ON, Canada.

34. DNA methylation array screening in salivary gland adenoid cystic carcinoma. Tan M, Shao C, Bishop JA, Fertig EJ, Considine M, Westra WH, Ha PK. Poster presentation to the Gordon Research Conference, Salivary Glands and Exocrine Biology From Development to Disease and Beyond, February 3-8, 2013, Galveston, TX. 35. Evaluation of WT1 promoter methylation in salivary adenoid cystic carcinoma. Sobel RH, Tan M, Shao C, Bishop J, Fertig EJ, Ha PK. Poster presentation to the American Head and Neck Society 2013 Meeting, April 10-11, 2013, Orlando, FL. 36. Collagen type XIV alpha 1 promoter hypermethylation is associated with advanced T stage in salivary gland adenoid cystic carcinoma. Tan M, Shao C, Bishop JA, Fertig EJ, Considine M, Westra WH, Ha PK. Poster presentation to the American Head and Neck Society 2013 Meeting, April 10-11, 2013, Orlando, FL. 37. Development of an objective training curriculum for transoral robotic surgery and its application to resident surgical training. Sobel RH, Ha PK, Califano JA, Blanco RG, Lee G, Kumar R, Richmon JD. Poster presentation to the American Head and Neck Society 2013 Meeting, April 10-11, 2013, Orlando, FL. 38. Outcomes of total laryngectomy: a single-institution experience, 2001-2013. Benson E, Hirata R, Thompson C, Ha PK, Fakhry C, Saunders JR, Califano J, Arnaoutakis D, Levine M, Neuner G, Messing BP, Blanco RG. Poster presentation at the 2014 Combined Sections Meeting, January 10-12, 2014, Miami Beach, FL. 39. Retropharyngeal lymph node involvement in human papilloma virus associated oropharyngeal squamous cell carcinoma. Baxter MC, Chan JY, Ha PK, Agrawal N. Poster presentation at the 2014 Combined Sections Meeting, January 10-12, 2014, Miami Beach, FL. 40. Transcervical ultrasonography is feasible to visualize and evaluate base of tongue cancers. Fakhry C, Califano J, Messing B, Richmon J, Quon H, Neuner G, Saunders J, Ha P, Gillison M, Blanco R. Multidisciplinary Head and Neck Symposium, February 2014, Scottsdale, AZ. 41. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Sobel R, Blanco R, Ha PK, Califano J, Kumar R, Richmon J. Oral presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 42. Transoral robotic surgery: does eating PO mean eating well. Messing BP, Califano JA, Ha P, Saunders J, Blanco R, Kim M, Hieber B, Fakhry C, Valasek L, Neuner G, Ryniak K, Silinonte J, Gebhart S. Poster presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 43. The efficacy of prophylactic swallow interventions in the head and neck cancer patient undergoing organ preservation cancer treatment. Messing BP, Califano JA, Ha PK, Blanco R, Saunders J, Fakhry C, Kim M, Hieber B, Valasek L, Gold D, Harrer K, Ulmer K, Gebhart S. Oral presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 44. Pharmacological unmasking of methylated critical genes by global demethylation and DNA methylation microarray screening in the xenografts of salivary gland adenoid cystic carcinoma. Ling S, Tan M, Wang Z, Bishop JA, Fertig EJ, Considine M, Ha PK. Poster presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY.

45. Methylation array screening for epigenetic alterations in salivary gland mucoepidermoid carcinoma. Wang Z, Ling S, Sobel R, Tan M, El-Naggar A, Ha PK. Poster presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 46. Ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. Fakhry C, Agrawal N, Califano J, Coquia S, Hamper U, Messing B, Ha P, Saunders J, Gillison M, Blanco R. Oral presentation to the 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY.

EDUCATIONAL ACTIVITIES Book Chapters 1. Molecular Biology of Head and Neck Cancer, Chapter 14. Ha PK, Goldenberg D, Wolpoe M, and Califano J. Otolaryngology-Head and Neck Surgery Fourth Edition, Cummings, et al. eds. Chapter 14, 402-420. Mosby, 2005. 2. Inpatient infections of the ear nose and throat. Schiffer J, Ha PK, Gebo K. The Osler Medical Handbook 2nd ed. Mosby-Yearbook, Inc, Submitted 2006. 3. Endoscopic laser surgery for early glottic carcinoma. Ha PK. Cummings Atlas of Laryngeal Surgery. Submitted 2007. 4. Molecular gene alterations as early detection markers. Smith IM, Califano JA, Ha PK. Early Detection of Cancer: Head and Neck Cancer. Submitted 2007 5. Molecular biology of head and neck cancer. Ha PK, Califano JA, Sidransky D. Head and Neck Cancer: A Multidisciplinary Approach, 3rd ed, Harrison LB et al eds. Chapter 31, 851860. Lippincott, Wilkins, and Williams, 2007. 6. Molecular biology of head and neck cancer, Chapter 76. Chang S, Califano J, and Ha PK. Otolaryngology-Head and neck Surgery, Fifth Edition. Cummings, et al. eds. Mosby, 2008. 7. Molecular biology of head and neck cancer, Agrawal N, Califano J, and Ha PK. DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 9th Edition. DeVita, et al. Eds. Chapter 71, 723-728. Lippincott, Wilkins and Williams, 2011. 8. Meeting the challenges of the human papillomavirus and oropharyngeal carcinoma, Ha PK. Meeting the challenges of oral and head and neck cancer: a guide for survivors and caregivers, 2nd edition. Leupold NE and Sciubba JJ eds. Plural Publishing, 2011. 9. The molecular biology of head and neck cancer. Tan M, Sobel R, Ha PK. OtolaryngologyHead and Neck Surgery, Sixth Edition. Cummings, et al. eds. Mosby. Submitted 2013 10. Anatomy, physiology, and non-neoplastic disorders of the salivary glands. Mydlarz WM, Ha PK, and Eisele DW. Sataloff’s Comprehensive Textbook of Otolaryngology, 1st edition. Gullane P and Goldstein eds. JP Medical Publishers, Submitted 2013. Other Media

1. Multimedia reviews in Otolaryngology – Head and Neck Surgery. Monthly contributions of oral and written journal reviews for CME credit. Oakstone Medical Publishing, 2006 2011. 2. The Baltimore Sun, July 10, 2014, page 3. Ask the Expert: salivary gland cancers are rare but can be deadly. Andrea K Walker as reporter. Teaching Classroom Instruction: 1. Salivary glands and you. Johns Hopkins Department of Otolaryngology, Resident Lecture Series, Baltimore, MD, March 2006. 2. PET/CT: Benefits and Pitfalls. Greater Baltimore Medical Center Head and Neck Cancer support group, Baltimore, MD September 2006. 3. Skin Cancer for the Otolaryngologist. Johns Hopkins Department of Otolaryngology, Resident Lecture Series, Baltimore, MD, September 2006. 4. Head and neck resident inservice review. Johns Hopkins Department of Otolaryngology. Baltimore, MD, February 2007. 5. Parotidectomy and thyroidectomy: why and what to expect. Greater Baltimore Medical Center Unit 58 Nurses Education, Baltimore, MD, February 5 & 23, 2007. 6. Parathyroid disease and surgery. Johns Hopkins Department of Otolaryngology, Resident Lecture Series. Baltimore, MD, February 23, 2007. 7. PET/CT: Benefits and Pitfalls. Greater Baltimore Medical Center Unit 58 Nurses education. Baltimore, MD, October 9, 2007. 8. Salivary gland diseases: a surgeon’s perspective. Johns Hopkins Department of Otolaryngology, Resident Lecture Series, Baltimore, MD, November 8, 2007. 9. An overview of head and neck cancer. Johns Hopkins School of Public Health. Course 180.650, Fundamentals of Clinical Oncology for Public Health Practitioners, Baltimore, MD, November 28, 2007, November 13, 2008, November 12, 2009, November 4, 2010, November 3, 2011, December 13, 2012. 10. Endoscopic laser surgery for early glottic and supraglottic carcinoma. The Maryland Society of Otolaryngology winter meeting, January 8, 2008. 11. Head and neck resident inservice review. Johns Hopkins Department of Otolaryngology. Baltimore, MD, February 14, 2008. 12. An overview of oropharyngeal cancer and HPV. Greater Baltimore Medical Center Oncology Lunch and Learn, Baltimore, MD. April 22, 2008. 13. Salivary gland diseases, case review. Johns Hopkins Department of Otolaryngology, Resident lecture series, Baltimore, MD, January 22, 2009. 14. Mock oral boards preparation. Johns Hopkins Department of Otolaryngology, Baltimore, MD, March 25, 2009. 15. Calcium management after thyroidectomy. Greater Baltimore Medical Center Unit 58 Nurses Education Day. Baltimore, MD, December 7, 2009 & January 11, 2010. 16. Parathyroid disease and surgery. Johns Hopkins Department of Otolaryngology, Resident lecture series, Baltimore, MD, December 21, 2009. 17. Parotidectomy. Johns Hopkins Department of Otolaryngology, Resident Head and Neck Dissection Course, Baltimore, MD, February 27, 2010, February 26, 2011, April 15, 2013, March 14, 2014. 18. Surgical and medical implications of head and neck cancer, Loyola College Graduate Center, Course SP 700.51-11 Head and Neck Cancer Rehabilitation. Columbia, MD, April 11, 2011, April 16, 2012, April 15, 2013, April 14, 2014. 19. Thyroidectomy: Surgery and Complications. Greater Baltimore Medical Center Nurses Education Day, June 21, 2012. 20. Who, when, and why: follow-up care after head and neck cancer treatment. Greater Baltimore Medical Center/Milton J. Dance Jr, Head and Neck Support Group, September 17, 2013.

Clinical Instruction: 1. Johns Hopkins Department of Otolaryngology, 1/06 – 7/06, Attending Head and Neck Surgeon with supervision of residents 2. Greater Baltimore Medical Center, 1/06 – present, Attending Head and Neck Surgeon with supervision of residents 3. Johns Hopkins Department of Otolaryngology, 1/06 – 1/08. Head and Neck Surgery monthly walk rounds 4. Greater Baltimore Medical Center, Otolaryngology Journal Club. Founder and leader of a monthly general journal review with residents and other members of the Otolaryngology staff, 7/06 - present 5. Johns Hopkins Department of Otolaryngology at the Greater Baltimore Medical Center, Johns Hopkins medical student clerkship founder and director, 1/09 – present 6. Greater Baltimore Medical Center, Otolaryngology Clinical-Pathologic Correlation. Organized and participate in a monthly CPC review of otolaryngologic cases along with Dr. James Sciubba, 5/10 – present CME Instruction 1. Significant head and neck squamous cell carcinomas of skin. Greater Baltimore Medical Center Grand Rounds, Baltimore, MD, October 2004. 2. Hurthle cell thyroid tumors and the role of adjuvant therapy. Greater Baltimore Medical Center Grand Rounds. Baltimore, MD, December 2004. 3. Revisiting the molecular biology of adenoid cystic carcinoma. 9th Annual Head and Neck Conference: Current Topics in Head and Neck Cancer. Greater Baltimore Medical Center, October 27, 2006. 4. Applications of endoscopic laser surgery. Greater Baltimore Medical Center Otolaryngology Grand Rounds, December 15, 2006. 5. Endoscopic laser surgery for glottic carcinoma. Updates in Head and Neck Surgery and Facial Plastic and Reconstructive Surgery. Johns Hopkins Department of Otolaryngology Biennial Meeting, June 1, 2007. 6. The pharyngoesophageal segment. Voice Restoration Following Total Laryngectomy: Management of the TEP. Greater Baltimore Medical Center, September 28, 2007. 7. A survey of head and neck cancer. Greater Baltimore Medical Center Internal Medicine Grand Rounds, November 15, 2007. 8. Videostroboscopic findings after endoscopic laser surgery. Greater Baltimore Medical Center Stroboscopy Rounds, March 14, 2008. 9. Topics in Geriatric Otolaryngology. Greater Baltimore Medical Center Otolaryngology Grand Rounds, Baltimore, MD. May 16, 2008. 10. The pharyngoesophageal segment. Voice Restoration Following Total Laryngectomy: the Tracheoesophageal Prosthesis. Greater Baltimore Medical Center, September 26, 2008. 11. Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma. 12th Annual Head and Neck Conference, Greater Baltimore Medical Center, Baltimore, MD, October 23, 2009. 12. Submandibular gland transfer for salivary protection. Society of Otorhinolaryngology – Head and Neck Nurses 15th Annual Maryland/DC Chapter Spring Seminar, Baltimore, MD, March 26, 2010. 13. Techniques in head and neck surgery. Maryland Speech Language Hearing Association, Annual Convention. March 26, 2010. 14. An analysis of two eras in head and neck cancer treatment at GBMC. 14th Annual Head and Neck Conference, Greater Baltimore Medical Center, Baltimore, MD, October 28, 2011.

15. Laryngectomy Dissection Course. Voice Restoration Following Total Laryngectomy: Management of the TEP. Greater Baltimore Medical Center, September 8, 2012 and September 28, 2013. 16. Techniques for preserving salivary gland function during head and neck cancer therapy. 15th Annual Head and Neck Conference on Head and Neck Rehabilitation, Greater Baltimore Medical Center, Baltimore, MD, October 26, 2012. 17. The management of well-differentiated thyroid cancer. Greater Baltimore Medical Center Head and Neck Grand Rounds, Baltimore, MD, May 4, 2013. 18. The use of CO2 laser in head and neck surgery. 16th Annual Head and Neck Conference on Interdisciplinary Rehabilitation, Greater Baltimore Medical Center, Baltimore, MD, October 25, 2013. 19. Adenoid cystic carcinoma: a molecular and clinical review. Head and Neck Grand Rounds, Greater Baltimore Medical Center, Baltimore, MD, November 1, 2013. Mentoring 1. Jong Chul Park, 6/06 – 4/07, MD internal medicine residency at East Carolina. 2. Megan Durr, 7/07 – 9/07, MD, currently an otolaryngology resident at University of California San Francisco, worked in my lab and on clinical studies. 3. Alexander Hillel, 1/08 – 7/08, MD, resident in otolaryngology at Johns Hopkins, Laryngology Fellow at Emory. Won best resident project at Greater Baltimore Medical Center, had oral presentation at the 7th International Conference on Head and Neck Cancer, San Francisco, California, July 19-23, 2008. 4. Chunbo Shao, MD PhD, 1/08 - postdoctoral fellow in the research lab. 5. David Mu, 6/08 – medical student at Johns Hopkins, worked on clinical research project involving adenoid cystic carcinoma at Johns Hopkins. 6. David Hill, 6/08 – 9/08, undergraduate student at Johns Hopkins, currently a medical student, worked on clinical research projects and shadowed me clinically. 7. Marietta Tan, 7/08 – 9/08, medical student at Johns Hopkins, now an otolaryngology resident at Johns Hopkins, worked on basic science research involving adenoid cystic carcinoma. 7/11 – 6/13, Johns Hopkins Otolaryngology Resident on T32 training grant, continuing work in the lab on adenoid cystic carcinoma. Recipient of American Academy of Otolaryngology Resident Research Grant (2012-3) 8. Michelle Sykes, 7/08 – 9/08, undergraduate student at Barnard College, worked on clinical research projects and shadowed me clinically. 9. Kelly Thompson, 1/09 – 9/10, postbaccalaureate student at University of Vermont, shadowed clinically. 10. Ana Ximenia Benitez, 6/09 – 7/09, high school student in Missouri, worked on lab research, clinical studies, and clinical experiences. 11. Simon Best, 7/09 – 7/10, resident in otolaryngology at Johns Hopkins, currently a fellow in Laryngology in Boston with Steven Zeitels. Worked on clinical research project evaluating the effects of chemoradiation on esophageal stricture development. 12. David Zaboli, 3/10 – 5/11, medical student at Johns Hopkins, currently an otolaryngology resident at Mount Sinai, worked on clinical research projects involving combined chemoradiation protocols. 13. Hrishikesh Gogenini, 3/10 – 8/10, medical student at Case Western, worked on clinical research project involving evaluation of chemoradiation protocols and aging. 14. Spencer Lake, 3/10 – 8/10, medical student at Johns Hopkins, worked on clinical research project evaluating chemoradiation protocols and weight loss. 15. Katie Fan, 3/10 – present, medical student at Johns Hopkins, worked on clinical research project comparing two different chemoradiation protocols. 16. Jia Liu, 6/10 – 5/11, medical student at Univerity of Pittsburgh, worked in lab on methylation alterations in adenoid cystic carcinoma, review article on the molecular biology of adenoid cystic carcinoma.

17. Irene Kim, 6/10 – 5/11, medical student at Johns Hopkins, currently an otolaryngology resident at UCLA, worked on clinical research project involving evaluation of the team approach to the care of head and neck cancer patients. 18. Jackie Junn, 6/10 – present, medical student at New York Medical College, worked in lab and on clinical research projects. 19. Justin Bishop, 1/11 – present. Faculty in Johns Hopkins Department of Pathology. Mentor for Career Development Award through the NIH/NIDCR U54, OD-08-001 Biomarker discovery and validation of salivary gland carcinomas by integrative multiplatform profiling. 20. Ryan Sobel, 7/12 – 6/13. Head and Neck Fellow in the Johns Hopkins Department of Otolaryngology. One year of research conducted in my lab, looking at the epigenetics of mucoepidermoid carcinoma. 21. Shizhang Ling, 5/13 - Postdoctoral Fellow in the head and neck cancer research lab. 22. Zhiming Wang, 7/13 – 7/14. Visiting scholar from Shengjing Hospital of China Medical University. 23. Ali Aygun. 6/14 – 8/14. High school senior from Gilman, Baltimore, MD.

Educational Courses Attended 1) Providing Effective Feedback: Essential Concepts and Advanced Applications. Johns Hopkins Faculty Development Program, June – July, 2009. 2) Society of University Otolaryngologists – Association of Academic Departments of Otolaryngology 2009 annual meeting, “Opportunities for Excellence.” Washington, DC, November 6-8, 2009. 3) Conflict Management and Professionalism Workshop. Johns Hopkins Faculty Development Program, June – July 2010. 4) The Heart of Mentorship: Effective Mentoring. Johns Hopkins Faculty Development Program, 8/11/11, 9/1/11, 2/2/12. 5) Society of University Otolaryngologists - Association of Academic Departments of Otolaryngology 2011 annual meeting, “Preparing for the workplace of the future.” Washington, DC, November 11-13, 2011. 6) Society of University Otolaryngologists – Association of Academic Departments of Otolaryngology 2013 annual meeting, “Otolaryngologist: Educator and Leader.” Washington, DC, November 15-17, 2013. 7) Society of University Otolaryngologists – Association of Academic Departments of Otolaryngology 2013 annual meeting, “Innovation: the Path to Progress.” Chicago, IL, November 7-9, 2014. CLINICAL ACTIVITIES Certification Maryland State Medical License: (3/06 – present) American Board of Otolaryngology: 6/06 Service Responsibilities Greater Baltimore Medical Center, Milton J Dance Jr Head and Neck Center. Attending Head and Neck Surgeon, 45% time commitment. ORGANIZATIONAL ACTIVITIES Institutional Administrative Appointments 2003-2005 Johns Hopkins Housestaff Council Member: 2003-2005

2005-2006 Residency Review Committee, Johns Hopkins Department of Otolaryngology 2007-2009 Electronic Medical Record Task Force, Greater Baltimore Medical Center 2008-2009 Office of Research Administration Advisory Committee, Johns Hopkins 2006 Residency Selection Committee, Johns Hopkins Department of Otolaryngology 2006 Residency Education Committee, Johns Hopkins Department of Otolaryngology 2007 Otolaryngology Advisory Committee, Greater Baltimore Medical Center 2008-2011 Otolaryngology Diversity Committee, JH Department of Otolaryngology 2008 Otolaryngology Credentialing Committee, Greater Baltimore Medical Center 2009 Director and Founder, GBMC Otolaryngology Medical Student Clerkship 2009 Division Preceptor, JHH/GBMC Otolaryngology Resident Rotation 2010 GBMC Otolaryngology Residency Local Program Director 2011-12 GBMC Otolaryngology Quality Assurance Committee Chair 2012 Associate Residency Program Director, Johns Hopkins Department of Otolaryngology 2012 Otolaryngology Advisory Committee Chair, Greater Baltimore Medical Center Editorial Activities Associate Section Editor: Head and Neck – 2014 - 2017 Editorial Board: World Journal of Radiology – 2009 – present Editorial Board: Oral Oncology – 2009 – present Editorial Board: Head and Neck – 2011 – 2014 (section editor) Editorial Board: Journal of Otolaryngology – 2011 – present Editorial Board: World Journal of Otorhinolaryngology – 2012 – present Reviewer for Head and Neck, 2002 – present Reviewer for Archives of Otolaryngology, 2005 – present Reviewer for Oral Oncology, 2005 – present Reviewer for The Journal of Pathology, 2006 - present Reviewer for Oncogene, 2006 - present Reviewer for Oral Diseases, 2007 - present Reviewer for Cancer Biology and Therapy, 2008 – present Reviewer for BMC Cancer, 2008 – present Reviewer for The Journal of Oral Pathology and Medicine, 2008 – present Reviewer for Molecular Carcinogenesis, 2008 – present Reviewer for Pathobiology, 2008 – present Reviewer for Annals of Surgical Oncology, 2008 – present Reviewer for Journal of Cancer Research and Therapeutics, 2009 – present Reviewer for Laryngoscope, 2009 – present Reviewer for The Journal of Dental Research, 2010 – present Reviewer for International Journal of Medical Sciences, 2011 – present Reviewer for PLoS One, 2011 – present Reviewer for Cancer, 2011 – present Reviewer for Human Pathology, 2012 – present Reviewer for Mitochondrial DNA, 2012 – present Reviewer for Cell Biology and Toxicology, 2013 – present Advisory Committees, Review Groups/Study Sections 2007 – present Cancer Research UK Grant Reviewer 8/10 – 8/11 Salivary Gland Tumor Biorepository Steering Committee 3/11 – 5/11 French National Institute for Cancer Grant Reviewer 2/21/13 NIH/NIDCR Review of NIDCR New Investigator R03, Fs and Ks, Ad hoc reviewer 7/13 – 6/17 NIH/NIDCR Special Grants Review Committee standing member 6/10/14 NIH/NIDCR ZRG1 MOSS-U02 Special Emphasis Panel grant review

Professional Societies American Academy of Cancer Research American Academy of Otolaryngology American College of Surgeons American Head and Neck Society

Member 2008 - current Member 2000 - current Member 2008 - current Member 2007- current Publications Committee Member 2006 - 2008 Meeting Program Committee Member: 2011-14 Research Committee Member: 2012-5 Johns Hopkins Medical and Surgical Assoc Member 1999 - current Maryland Society of Otolaryngology Member 2000 - current Secretary/Treasurer 2007-8 President 2008-9 Society of University Otolaryngologists Member 2008 RECOGNITION Harvard College Magna Cum Laude with Highest Honors in Biology John Harvard Scholarship winner (1992-93, 1993-94, 1994-95) Harvard College Scholarship winner (1991-92) Ford Foundation Scholarship recipient for research endeavors Johns Hopkins School of Medicine Elected Alpha Omega Alpha, 1999 Johns Hopkins Department of Otolaryngology Greater Baltimore Medical Center Resident Research Forum award winner 2001 Recipient of the Henkel Chief Resident Teacher of the Year Award 2005 Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005 Recipient of Tilghman Travel Fellowship: used for advanced training in endoscopic laser surgery (Kiel, Germany, Professor Petra Ambrosch) April 2006 Recipient of John C. Price GBMC Faculty Teaching Award 2006-7, 2010-11 Recipient of Johns Hopkins Otolaryngology Faculty Teaching Award 2006-7, 2010-11 Voted “Top Doctor” in Head and Neck Surgical Oncology from Baltimore Magazine, November, 2010, 2012, 2013, 2014. Recognized as America’s Most Compassionate Doctors, Patients’ Choice Award, 2013 Invited Talks, Panels 1. Thyroid and parathyroid surgery and postoperative complications. Invited speaker. Society of Otorhinolaryngology and Head-Neck Nurses 13th Annual Spring Meeting, Baltimore, MD. March 28, 2008 2. Panel Discussion: Genetics/Epigenetics in Head and Neck Cancers. Genetic alterations in adenoid cystic carcinoma. American Head and Neck Society, 8th International Meeting, San Francisco, CA. July 21, 2008 3. Methylation and adenoid cystic carcinoma. Ha PK. Invited speaker. Workshop on salivary gland tumor research: current status and future directions. National Institutes of Health/National Institute of Dental and Craniofacial Research, Bethesda, MD, November 17, 2008 4. An Overview of the Clinical Management of Head and Neck Cancer. Society of Nuclear Medicine Continuing Education: Head and Neck CT and PET/CT Anatomy for Nuclear Medicine, Read With the Experts, Part I&II. SNM Annual Meeting, Toronto, Canada, June 15, 2009 5. Molecular Detection Strategies in Oral Squamous Cell Carcinoma. Panelist and Presenter. Second World Congress of the International Oral Oncology, Toronto, Canada, July 9, 2009

6. De-methylation and oncogene identification in adenoid cystic carcinoma. Adenoid Cystic Carcinoma Research Foundation Scientific Advisory Board meeting, Boston, MA, November 2, 2009. 7. Salivary gland cancer: past, present, and future. University of California Davis Otolaryngology Grand Rounds, Sacramento, CA, November 23, 2009. 8. Advances in Laser-Based Head and Neck Surgery. The Greater Baltimore Medical Center Oral and Maxillofacial Surgery Study Club, Baltimore, MD, September 21, 2010. 9. The Milton J. Dance, Jr. Head and Neck Experience: Multidisciplinary care from diagnosis through treatment and beyond. Panelist and Moderator. Milton J Dance, Jr. Head and Neck Center 13th Annual Conference on Head and Neck Rehabilitation: Multidisciplinary care, Baltimore, MD, October 22, 2010. 10. Salivary malignancies: basic and translational science. Co-Chair of scientific session, American Head and Neck Society 2010 Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancers. Arlington, VA., October 30, 2010. 11. Epigenetic alterations in salivary gland tumors. Invited speaker, American Head and Neck Society 2010 Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancers. Arlington, VA., October 30, 2010. 12. Translational science in head and neck cancer research. Poster Tour Leader. American Head and Neck Society 2011 Annual Meeting, Chicago, IL, April 27-28, 2011. 13. Adenoid cystic carcinoma: new molecular driven approaches in 2012. Invited panelist. Multidisciplinary Head and Neck Cancer Symposium (AHNS, ASCO, ASTRO, SNM), Phoenix, AZ, January 27, 2012. 14. Moderator: Infrastructure, Pathobiology, Epidemiology Breakout Session. Workshop on Salivary Gland Tumor Research: Current Status and Future Directions. Bethesda, MD, February 6-7, 2012. 15. Diagnostic and Surgical Management of Salivary Gland Cancers, Panel on Salivary Gland Malignancy. 8th International Conference on Head and Neck Cancer, Toronto, ON, Canada, July 21-25, 2012. 16. Moderator: Proffered Papers: Epigenetics. 8th International Conference on Head and Neck Cancer, Toronto, ON, Canada, July 21-25, 2012. 17. Xerostomia during primary chemoradiation: every millimeter counts. Society of Otorhinolaryngology and Head-Neck Nurses 37th Annual Congress and Nursing Symposium. Washington, D.C., September 9, 2012. 18. Panelist: Management of salivary gland malignancies: update 2012, Diagnostic workup of salivary gland tumors. American Academy of Otolaryngology-Head and Neck Surgery 2012 Annual Meeting, Washington, D.C., September 11, 2012. 19. Invited Speaker/Panelist: Promoter methylation alterations in adenoid cystic carcinoma. Gordon Research Conference, Salivary Glands & Exocrine Biology: From Development to Disease & Beyond, Galveston, TX, February 7, 2013. 20. Endoscopic laser surgery: practical applications. Vanderbilt University Department of Otolaryngology, October 7, 2013. 21. Adenoid Cystic Carcinoma: playing catch up. Johns Hopkins Department of Pathology Grand Rounds, March 24, 2014. 22. Moderator, Oral Cavity III proferred papers. 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 23. Moderator, Molecular Genetics II proferred papers. 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 24. Panelist/moderator, Lunch with professor, Update on molecular oncology. 2014 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, 2014, New York, NY. 25. Panelist/moderator, Issues of survivorship for HPV-positive head and neck cancer patients. Updates in HPV and Head and Neck Cancer, Johns Hopkins Department of Otolaryngology Head and Neck Surgery, November 1, 2014, Baltimore, MD.

Volunteer Work Head and Neck Cancer Awareness Week – oral cancer screening at GBMC. April 24, 2008